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1. Design of pseudosymmetric protein hetero-oligomers

Author

Kibler, Ryan D., Lee, Sangmin, Kennedy, Madison A., Wicky, Basile I. M., Lai, Stella M., Kostelic, Marius M., Carr, Ann, Li, Xinting, Chow, Cameron M., Nguyen, Tina K., Carter, Lauren, Wysocki, Vicki H., Stoddard, Barry L., and Baker, David

Published
2024
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3. De novo design of protein structure and function with RFdiffusion

Author

Watson, Joseph L., Juergens, David, Bennett, Nathaniel R., Trippe, Brian L., Yim, Jason, Eisenach, Helen E., Ahern, Woody, Borst, Andrew J., Ragotte, Robert J., Milles, Lukas F., Wicky, Basile I. M., Hanikel, Nikita, Pellock, Samuel J., Courbet, Alexis, Sheffler, William, Wang, Jue, Venkatesh, Preetham, Sappington, Isaac, Torres, Susana Vázquez, Lauko, Anna, De Bortoli, Valentin, Mathieu, Emile, Ovchinnikov, Sergey, Barzilay, Regina, Jaakkola, Tommi S., DiMaio, Frank, Baek, Minkyung, and Baker, David

Published
2023
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6. Fjord-Edge Graphene Nanoribbons with Site-Specific Nitrogen Substitution

Author

Li, Yolanda L, Zee, Chih-Te, Lin, Janice B, Basile, Victoria M, Muni, Mit, Flores, Maria D, Munárriz, Julen, Kaner, Richard B, Alexandrova, Anastassia N, Houk, KN, Tolbert, Sarah H, and Rubin, Yves

Subjects
Chemical Sciences, Graphite, Models, Molecular, Molecular Structure, Nanotubes, Carbon, Nitrogen, General Chemistry, Chemical sciences, Engineering
Abstract

The synthesis of graphene nanoribbons (GNRs) that contain site-specifically substituted backbone heteroatoms is one of the essential goals that must be achieved in order to control the electronic properties of these next generation organic materials. We have exploited our recently reported solid-state topochemical polymerization/cyclization-aromatization strategy to convert the simple 1,4-bis(3-pyridyl)butadiynes 3a,b into the fjord-edge nitrogen-doped graphene nanoribbon structures 1a,b (fjord-edge N2[8]GNRs). Structural assignments are confirmed by CP/MAS 13C NMR, Raman, and XPS spectroscopy. The fjord-edge N2[8]GNRs 1a,b are promising precursors for the novel backbone nitrogen-substituted N2[8]AGNRs 2a,b. Geometry and band calculations on N2[8]AGNR 2c indicate that this class of nanoribbons should have unusual bonding topology and metallicity.

Published
2020

7. Tunable Dopants with Intrinsic Counterion Separation Reveal the Effects of Electron Affinity on Dopant Intercalation and Free Carrier Production in Sequentially Doped Conjugated Polymer Films

Author

Aubry, Taylor J, Winchell, KJ, Salamat, Charlene Z, Basile, Victoria M, Lindemuth, Jeffrey R, Stauber, Julia M, Axtell, Jonathan C, Kubena, Rebecca M, Phan, Minh D, Bird, Matthew J, Spokoyny, Alexander M, Tolbert, Sarah H, and Schwartz, Benjamin J

Subjects
Engineering, Macromolecular and Materials Chemistry, Materials Engineering, Chemical Sciences, counterion distance, doping efficiency, electronic offset, molecular dopants, redox-driven infiltration, semiconducting polymers, tunable electron affinity, redox‐driven infiltration, Physical Sciences, Materials, Chemical sciences, Physical sciences
Abstract

Carrier mobility in doped conjugated polymers is limited by Coulomb interactions with dopant counterions. This complicates studying the effect of the dopant's oxidation potential on carrier generation because different dopants have different Coulomb interactions with polarons on the polymer backbone. Here, dodecaborane (DDB)-based dopants are used, which electrostatically shield counterions from carriers and have tunable redox potentials at constant size and shape. DDB dopants produce mobile carriers due to spatial separation of the counterion, and those with greater energetic offsets produce more carriers. Neutron reflectometry indicates that dopant infiltration into conjugated polymer films is redox-potential-driven. Remarkably, X-ray scattering shows that despite their large 2-nm size, DDBs intercalate into the crystalline polymer lamellae like small molecules, indicating that this is the preferred location for dopants of any size. These findings elucidate why doping conjugated polymers usually produces integer, rather than partial charge transfer: dopant counterions effectively intercalate into the lamellae, far from the polarons on the polymer backbone. Finally, it is shown that the IR spectrum provides a simple way to determine polaron mobility. Overall, higher oxidation potentials lead to higher doping efficiencies, with values reaching 100% for driving forces sufficient to dope poorly crystalline regions of the film.

Published
2020

8. Self-Awareness

Author

Basile, Benjamin M., Brown, Emily Kathryn, Hampton, Robert R., Clary, Dawson, Section editor, Vonk, Jennifer, editor, and Shackelford, Todd K., editor

Published
2022
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9. Rehearsal

Author

Basile, Benjamin M., Dufour, Valerie, Section editor, Vonk, Jennifer, editor, and Shackelford, Todd K., editor

Published
2022
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10. Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants

Author

Zhang, Jason Z., Yeh, Hsien-Wei, Walls, Alexandra C., Wicky, Basile I. M., Sprouse, Kaitlin R., VanBlargan, Laura A., Treger, Rebecca, Quijano-Rubio, Alfredo, Pham, Minh N., Kraft, John C., Haydon, Ian C., Yang, Wei, DeWitt, Michelle, Bowen, John E., Chow, Cameron M., Carter, Lauren, Ravichandran, Rashmi, Wener, Mark H., Stewart, Lance, Veesler, David, Diamond, Michael S., Greninger, Alexander L., Koelle, David M., and Baker, David

Published
2022
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11. Dodecaborane-Based Dopants Designed to Shield Anion Electrostatics Lead to Increased Carrier Mobility in a Doped Conjugated Polymer.

Author

Aubry, Taylor J, Axtell, Jonathan C, Basile, Victoria M, Winchell, KJ, Lindemuth, Jeffrey R, Porter, Tyler M, Liu, Ji-Yuan, Alexandrova, Anastassia N, Kubiak, Clifford P, Tolbert, Sarah H, Spokoyny, Alexander M, and Schwartz, Benjamin J

Subjects
Coulomb screening, dodecaboranes, mobility, molecular dopants, semiconducting polymers, Physical Sciences, Chemical Sciences, Engineering, Nanoscience & Nanotechnology
Abstract

One of the most effective ways to tune the electronic properties of conjugated polymers is to dope them with small-molecule oxidizing agents, creating holes on the polymer and molecular anions. Undesirably, strong electrostatic attraction from the anions of most dopants localizes the holes created on the polymer, reducing their mobility. Here, a new strategy utilizing a substituted boron cluster as a molecular dopant for conjugated polymers is employed. By designing the cluster to have a high redox potential and steric protection of the core-localized electron density, highly delocalized polarons with mobilities equivalent to films doped with no anions present are obtained. AC Hall effect measurements show that P3HT films doped with these boron clusters have conductivities and polaron mobilities roughly an order of magnitude higher than films doped with F4 TCNQ, even though the boron-cluster-doped films have poor crystallinity. Moreover, the number of free carriers approximately matches the number of boron clusters, yielding a doping efficiency of ≈100%. These results suggest that shielding the polaron from the anion is a critically important aspect for producing high carrier mobility, and that the high polymer crystallinity required with dopants such as F4 TCNQ is primarily to keep the counterions far from the polymer backbone.

Published
2019

14. “I’m Torn”: Qualitative Analysis of Dental Practitioner-Perceived Barriers, Facilitators, and Solutions to HPV Vaccine Promotion

Author

JaKa, Meghan M., primary, Henderson, Maren S. G., additional, Gillesby, Amanda D., additional, Zibley, Laura J., additional, Basile, Sarah M., additional, Michalowicz, Bryan S., additional, Worley, Donald, additional, Kharbanda, Elyse O., additional, Asche, Steve E., additional, Mabry, Patricia L., additional, and Rindal, Brad D., additional

Published
2024
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16. La miniatura a Milano nel IX secolo

Author

Basile Weatherill, M., Beretta, M., Tessera, M.R., Rossi, Marco, Rossi Marco (ORCID:0000-0001-7078-7812), Basile Weatherill, M., Beretta, M., Tessera, M.R., Rossi, Marco, and Rossi Marco (ORCID:0000-0001-7078-7812)

Abstract

Il contributo, pubblicato in un volume dedicato all'arcivescovo Ansperto da Biassono, cerca d'individuare i codici miniati allestiti a Milano nel IX secolo, escludendo i tre Salteri diacritici ambrosiani ritenuti del secolo successivo. Sono presentati alcuni manoscritti, anche inediti, della Biblioteca di Sant'Ambrogio, altri allestiti presso lo stesso monastero e infine ci si sofferma sul ms. lat. 7900A della BnF, proveniente da Milano.

Published
2024

17. Activity Prediction of Business Process Instances with Inception CNN Models

Author

Di Mauro, Nicola, Appice, Annalisa, Basile, Teresa M. A., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Alviano, Mario, editor, Greco, Gianluigi, editor, and Scarcello, Francesco, editor

Published
2019
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19. GRASP and path-relinking for Coalition Structure Generation

Author

Di Mauro, Nicola, Basile, Teresa M. A., Ferilli, Stefano, and Esposito, Floriana

Subjects
Computer Science - Artificial Intelligence
Abstract

In Artificial Intelligence with Coalition Structure Generation (CSG) one refers to those cooperative complex problems that require to find an optimal partition, maximising a social welfare, of a set of entities involved in a system into exhaustive and disjoint coalitions. The solution of the CSG problem finds applications in many fields such as Machine Learning (covering machines, clustering), Data Mining (decision tree, discretization), Graph Theory, Natural Language Processing (aggregation), Semantic Web (service composition), and Bioinformatics. The problem of finding the optimal coalition structure is NP-complete. In this paper we present a greedy adaptive search procedure (GRASP) with path-relinking to efficiently search the space of coalition structures. Experiments and comparisons to other algorithms prove the validity of the proposed method in solving this hard combinatorial problem.

Published
2011

20. Feature Construction for Relational Sequence Learning

Author

Di Mauro, Nicola, Basile, Teresa M. A., Ferilli, Stefano, and Esposito, Floriana

Subjects
Computer Science - Artificial Intelligence, Computer Science - Learning
Abstract

We tackle the problem of multi-class relational sequence learning using relevant patterns discovered from a set of labelled sequences. To deal with this problem, firstly each relational sequence is mapped into a feature vector using the result of a feature construction method. Since, the efficacy of sequence learning algorithms strongly depends on the features used to represent the sequences, the second step is to find an optimal subset of the constructed features leading to high classification accuracy. This feature selection task has been solved adopting a wrapper approach that uses a stochastic local search algorithm embedding a naive Bayes classifier. The performance of the proposed method applied to a real-world dataset shows an improvement when compared to other established methods, such as hidden Markov models, Fisher kernels and conditional random fields for relational sequences., Comment: 15 pages

Published
2010

21. GRASP for the Coalition Structure Formation Problem

Author

Di Mauro, Nicola, Basile, Teresa M. A., Ferilli, Stefano, and Esposito, Floriana

Subjects
Computer Science - Artificial Intelligence, Computer Science - Multiagent Systems
Abstract

The coalition structure formation problem represents an active research area in multi-agent systems. A coalition structure is defined as a partition of the agents involved in a system into disjoint coalitions. The problem of finding the optimal coalition structure is NP-complete. In order to find the optimal solution in a combinatorial optimization problem it is theoretically possible to enumerate the solutions and evaluate each. But this approach is infeasible since the number of solutions often grows exponentially with the size of the problem. In this paper we present a greedy adaptive search procedure (GRASP) to efficiently search the space of coalition structures in order to find an optimal one. Experiments and comparisons to other algorithms prove the validity of the proposed method in solving this hard combinatorial problem., Comment: 12 pages, Submitted to an International Conference

Published
2010

22. Improving Protein Expression, Stability, and Function with ProteinMPNN

Author

Sumida, Kiera H., primary, Núñez-Franco, Reyes, additional, Kalvet, Indrek, additional, Pellock, Samuel J., additional, Wicky, Basile I. M., additional, Milles, Lukas F., additional, Dauparas, Justas, additional, Wang, Jue, additional, Kipnis, Yakov, additional, Jameson, Noel, additional, Kang, Alex, additional, De La Cruz, Joshmyn, additional, Sankaran, Banumathi, additional, Bera, Asim K., additional, Jiménez-Osés, Gonzalo, additional, and Baker, David, additional

Published
2024
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25. A Combined Approach of Multiscale Texture Analysis and Interest Point/Corner Detectors for Microcalcifications Diagnosis

Author

Losurdo, Liliana, Fanizzi, Annarita, Basile, Teresa M. A., Bellotti, Roberto, Bottigli, Ubaldo, Dentamaro, Rosalba, Didonna, Vittorio, Fausto, Alfonso, Massafra, Raffaella, Monaco, Alfonso, Moschetta, Marco, Popescu, Ondina, Tamborra, Pasquale, Tangaro, Sabina, La Forgia, Daniele, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Rojas, Ignacio, editor, and Ortuño, Francisco, editor

Published
2018
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26. Density Estimators for Positive-Unlabeled Learning

Author

Basile, Teresa M. A., Di Mauro, Nicola, Esposito, Floriana, Ferilli, Stefano, Vergari, Antonio, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Appice, Annalisa, editor, Loglisci, Corrado, editor, Manco, Giuseppe, editor, Masciari, Elio, editor, and Ras, Zbigniew W., editor

Published
2018
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27. Extremely Randomized CNets for Multi-label Classification

Author

Basile, Teresa M. A., Di Mauro, Nicola, Esposito, Floriana, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Ghidini, Chiara, editor, Magnini, Bernardo, editor, Passerini, Andrea, editor, and Traverso, Paolo, editor

Published
2018
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30. Fast and Accurate Density Estimation with Extremely Randomized Cutset Networks

Author

Di Mauro, Nicola, Vergari, Antonio, Basile, Teresa M. A., Esposito, Floriana, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Ceci, Michelangelo, editor, Hollmén, Jaakko, editor, Todorovski, Ljupčo, editor, Vens, Celine, editor, and Džeroski, Sašo, editor

Published
2017
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32. Improving protein expression, stability, and function with ProteinMPNN

Author

Sumida, Kiera H., primary, Núñez-Franco, Reyes, additional, Kalvet, Indrek, additional, Pellock, Samuel J., additional, Wicky, Basile I. M., additional, Milles, Lukas F., additional, Dauparas, Justas, additional, Wang, Jue, additional, Kipnis, Yakov, additional, Jameson, Noel, additional, Kang, Alex, additional, De La Cruz, Joshmyn, additional, Sankaran, Banumathi, additional, Bera, Asim K., additional, Jiménez-Osés, Gonzalo, additional, and Baker, David, additional

Published
2023
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36. Learning Bayesian Random Cutset Forests

Author

Di Mauro, Nicola, Vergari, Antonio, Basile, Teresa M. A., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Esposito, Floriana, editor, Pivert, Olivier, editor, Hacid, Mohand-Said, editor, Rás, Zbigniew W., editor, and Ferilli, Stefano, editor

Published
2015
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37. Motor System-Dependent Effects of Amygdala and Ventral Striatum Lesions on Explore-Exploit Behaviors.

Author

Giarrocco, Franco, Costa, Vincent D., Basile, Benjamin M., Pujara, Maia S., Murray, Elisabeth A., and Averbeck, Bruno B.

Subjects
CHOICE (Psychology), AMYGDALOID body, RHESUS monkeys, REWARD (Psychology), REINFORCEMENT learning, MONKEYS
Abstract

Deciding whether to forego immediate rewards or explore new opportunities is a key component of flexible behavior and is critical for the survival of the species. Although previous studies have shown that different cortical and subcortical areas, including the amygdala and ventral striatum (VS), are implicated in representing the immediate (exploitative) and future (explorative) value of choices, the effect of the motor system used to make choices has not been examined. Here, we tested male rhesus macaques with amygdala or VS lesions on two versions of a three-arm bandit task where choices were registered with either a saccade or an arm movement. In both tasks we presented the monkeys with explore-exploit tradeoffs by periodically replacing familiar options with novel options that had unknown reward probabilities. We found that monkeys explored more with saccades but showed better learning with arm movements. VS lesions caused the monkeys to be more explorative with arm movements and less explorative with saccades, although this may have been due to an overall decrease in performance. VS lesions affected the monkeys' ability to learn novel stimulus-reward associations in both tasks, while after amygdala lesions this effect was stronger when choices were made with saccades. Further, on average, VS and amygdala lesions reduced the monkeys' ability to choose better options only when choices were made with a saccade. These results show that learning reward value associations to manage explore-exploit behaviors is motor system dependent and they further define the contributions of amygdala and VS to reinforcement learning. [ABSTRACT FROM AUTHOR]

Published
2024
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38. De novo design of monomeric helical bundles for pH‐controlled membrane lysis.

Author

Goldbach, Nicolas, Benna, Issa, Wicky, Basile I. M., Croft, Jacob T., Carter, Lauren, Bera, Asim K., Nguyen, Hannah, Kang, Alex, Sankaran, Banumathi, Yang, Erin C., Lee, Kelly K., and Baker, David

Abstract

Targeted intracellular delivery via receptor‐mediated endocytosis requires the delivered cargo to escape the endosome to prevent lysosomal degradation. This can in principle be achieved by membrane lysis tightly restricted to endosomal membranes upon internalization to avoid general membrane insertion and lysis. Here, we describe the design of small monomeric proteins with buried histidine containing pH‐responsive hydrogen bond networks and membrane permeating amphipathic helices. Of the 30 designs that were experimentally tested, all expressed in Escherichia coli, 13 were monomeric with the expected secondary structure, and 4 designs disrupted artificial liposomes in a pH‐dependent manner. Mutational analysis showed that the buried histidine hydrogen bond networks mediate pH‐responsiveness and control lysis of model membranes within a very narrow range of pH (6.0–5.5) with almost no lysis occurring at neutral pH. These tightly controlled lytic monomers could help mediate endosomal escape in designed targeted delivery platforms. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Stepwise design of pseudosymmetric protein hetero-oligomers

Author

Kibler, Ryan Daniel, primary, Lee, Sangmin, additional, Kennedy, Madison A., additional, Wicky, Basile I. M., additional, Lai, Stella M., additional, Kostelic, Marius M., additional, Li, Xinting, additional, Chow, Cameron M., additional, Carter, Lauren, additional, Wysocki, Vicki H., additional, Stoddard, Barry L, additional, and Baker, David, additional

Published
2023
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40. Stepwise design of pseudosymmetric protein hetero-oligomers

Author

Ryan D. Kibler, Sangmin Lee, Madison A. Kennedy, Basile I. M. Wicky, Stella M. Lai, Marius M. Kostelic, Xinting Li, Cameron M. Chow, Lauren Carter, Vicki H. Wysocki, Barry L. Stoddard, and David Baker

Abstract

Pseudosymmetric hetero-oligomers with three or more unique subunits with overall structural (but not sequence) symmetry play key roles in biology, and systematic approaches for generating such proteinsde novowould provide new routes to controlling cell signaling and designing complex protein materials. However, thede novodesign of protein hetero-oligomers with three or more distinct chains with nearly identical structures is a challenging problem because it requires the accurate design of multiple protein-protein interfaces simultaneously. Here, we describe a divide-and-conquer approach that breaks the multiple-interface design challenge into a set of more tractable symmetric single-interface redesign problems, followed by structural recombination of the validated homo-oligomers into pseudosymmetric hetero-oligomers. Starting fromde novodesigned circular homo-oligomers composed of 9 or 24 tandemly repeated units, we redesigned the inter-subunit interfaces to generate 15 new homo-oligomers and recombined them to make 17 new hetero-oligomers, including ABC heterotrimers, A2B2 heterotetramers, and A3B3 and A2B2C2 heterohexamers which assemble with high structural specificity. The symmetric homo-oligomers and pseudosymmetric hetero-oligomers generated for each system share a common backbone, and hence are ideal building blocks for generating and functionalizing larger symmetric assemblies.Significance StatementProtein oligomers composed of multiple unique subunits are versatile building blocks for creating functional materials and controlling biological processes. However, designing robust hetero-oligomers with distinct subunits and precise structural symmetry remains a major challenge. Here, we present a general strategy for designing such complexes by breaking down the problem into simpler steps by first symmetrically re-designing the interfaces of homo-oligomeric proteins, and then recombining validated variants to form pseudosymmetric hetero-oligomers. Using this method, we generated 17 hetero-oligomers with up to three unique subunits that assemble with high specificity. Our approach can be extended to create a wide range of pseudosymmetric assemblies for manipulating cellular signaling and as building blocks for advanced protein materials. These pseudosymmeteric heterotrimers have already enabled the construction of a set of massive nanocages, including a T=4 icosahedral nanocage with a 70 nm diameter and 240 subunits.1

Published
2023
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46. Plugging Numeric Similarity in First-Order Logic Horn Clauses Comparison

Author

Ferilli, S., Basile, T. M. A., Di Mauro, N., Esposito, F., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Pirrone, Roberto, editor, and Sorbello, Filippo, editor

Published
2011
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47. Cytoplasm Image Segmentation by Spatial Fuzzy Clustering

Author

Caponetti, Laura, Castellano, Giovanna, Corsini, Vito, Basile, Teresa M. A., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Fanelli, Anna Maria, editor, Pedrycz, Witold, editor, and Petrosino, Alfredo, editor

Published
2011
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48. A Multi-relational Learning Framework to Support Biomedical Applications

Author

Basile, Teresa M. A., Esposito, Floriana, Caponetti, Laura, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Istrail, Sorin, editor, Pevzner, Pavel, editor, Waterman, Michael S., editor, Rizzo, Riccardo, editor, and Lisboa, Paulo J. G., editor

Published
2011
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49. Optimizing Probabilistic Models for Relational Sequence Learning

Author

Di Mauro, Nicola, Basile, Teresa M. A., Ferilli, Stefano, Esposito, Floriana, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Kryszkiewicz, Marzena, editor, Rybinski, Henryk, editor, Skowron, Andrzej, editor, and Raś, Zbigniew W., editor

Published
2011
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50. A Taxonomic Generalization Technique for Natural Language Processing

Author

Ferilli, Stefano, Di Mauro, Nicola, Basile, Teresa M. A., Esposito, Floriana, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Kryszkiewicz, Marzena, editor, Rybinski, Henryk, editor, Skowron, Andrzej, editor, and Raś, Zbigniew W., editor

Published
2011
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