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118 results on '"Basel, Matthew T."'

3. Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies

Author

Keck, Sarah A, primary, Mullen, Nathan, additional, Taylor, Angela E, additional, Gliligan, Lorna C, additional, Pyle, Marla, additional, Shrestha, Tej B, additional, Sebek, Jan, additional, Highland, Margarat A, additional, Challapalli, Ritihaas, additional, Arlt, Wiebke, additional, Bossmann, Stefan H, additional, Dennedy, Michael Conall, additional, Prakash, Punit, additional, and Basel, Matthew T, additional

Published
2024
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4. Thermosensitive Liposomes for Gemcitabine Delivery to Pancreatic Ductal Adenocarcinoma.

Author

Aparicio-Lopez, Cesar B., Timmerman, Sarah, Lorino, Gabriella, Rogers, Tatiana, Pyle, Marla, Shrestha, Tej B., and Basel, Matthew T.

Subjects
ADENOCARCINOMA, PHOSPHOLIPIDS, RESEARCH funding, FEVER, DESCRIPTIVE statistics, PANCREATIC tumors, CANCER chemotherapy, POLYETHYLENE glycol, GEMCITABINE, DUCTAL carcinoma, MICROSCOPY
Abstract

Simple Summary: Pancreatic cancer is one of the most deadly forms of cancer. Current treatment options often fail because too little of the chemotherapy gets into the cancer. Hyperthermia, or heat treatment, has shown some promise in treating pancreatic cancer and may make it more likely for the chemotherapy to enter into the cancer. This study aims to design liposomes that can increase the amount of chemotherapy reaching pancreatic cancer by targeting the liposomes with hyperthermia. Treatment of pancreatic ductal adenocarcinoma with gemcitabine is limited by an increased desmoplasia, poor vascularization, and short plasma half-life. Heat-sensitive liposomes modified by polyethylene glycol (PEG; PEGylated liposomes) can increase plasma stability, reduce clearance, and decrease side effects. Nevertheless, translation of heat-sensitive liposomes to the clinic has been hindered by the low loading efficiency of gemcitabine and by the difficulty of inducing hyperthermia in vivo. This study was designed to investigate the effect of phospholipid content on the stability of liposomes at 37 °C and their release under hyperthermia conditions; this was accomplished by employing a two-stage heating approach. First the liposomes were heated at a fast rate, then they were transferred to a holding bath. Thermosensitive liposomes formulated with DPPC: DSPC: PEG2k (80:15:5, mole%) exhibited minimal release of carboxyfluorescein at 37 °C over 30 min, indicating stability under physiological conditions. However, upon exposure to hyperthermic conditions (43 °C and 45 °C), these liposomes demonstrated a rapid and significant release of their encapsulated content. The encapsulation efficiency for gemcitabine was calculated at 16.9%. Additionally, fluorescent analysis during the removal of unencapsulated gemcitabine revealed an increase in pH. In vitro tests with BxPC3 and KPC cell models showed that these thermosensitive liposomes induced a heat-dependent cytotoxic effect comparable to free gemcitabine at temperatures above 41 °C. This study highlights the effectiveness of the heating mechanism and cell models in understanding the current challenges in developing gemcitabine-loaded heat-sensitive liposomes. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Rationally designed peptide nanosponges for cell-based cancer therapy

Author

Wang, Hongwang, Yapa, Asanka S., Kariyawasam, Nilusha L., Shrestha, Tej B., Kalubowilage, Madumali, Wendel, Sebastian O., Yu, Jing, Pyle, Marla, Basel, Matthew T., Malalasekera, Aruni P., Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S., Huang, Hongzhou, Sun, Susan X., Smith, Paul E., Troyer, Deryl L., and Bossmann, Stefan H.

Published
2017
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13. System for delivering microwave ablation to subcutaneous tumors in small-animals under high-field MRI thermometry guidance

Author

Sebek, Jan, primary, Shrestha, Tej B., additional, Basel, Matthew T., additional, Chamani, Faraz, additional, Zeinali, Nooshin, additional, Mali, Ivina, additional, Payne, Macy, additional, Timmerman, Sarah A., additional, Faridi, Pegah, additional, Pyle, Marla, additional, O’Halloran, Martin, additional, Dennedy, M. Conall, additional, Bossmann, Stefan H., additional, and Prakash, Punit, additional

Published
2022
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15. Stem cell-based photodynamic therapy

Author

Shrestha, Tej B., Seo, Gwi M., Basel, Matthew T., Kalita, Mausam, Wang, Hongwang, Villanueva, David, Pyle, Marla, Balivada, Sivasai, Rachakatla, Raja Shekar, Shinogle, Heather, Thapa, Prem S., Moore, David, Troyer, Deryl L., and Bossmann, Stefan H.

Published
2012
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19. Preparing students to apply to and succeed in medical professional schools.

Author

Basel, Matthew T., Malreddy, Pradeep, Schultz, Bruce, Peying Fong, Coetzee, Johann F., and Rush, Bonnie R.

Subjects
*PROFESSIONAL schools, *MEDICAL schools, *STUDENTS, *EMBRYOLOGY, *VETERINARY colleges, *HUMAN anatomy
Abstract

The article focuses on Kansas State University's One Year Master's (OYM) in Biomedical Sciences program, designed to enhance students' qualifications for medical professional school admission. Topics include the program's curriculum in foundational medical sciences, its support for underrepresented minority students, and its strong outcomes, with 89.5 present of graduates gaining acceptance into professional schools such as DVM, MD, and DDS programs.

Published
2024
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23. Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells

Author

Yapa, Asanka S., Wang, Hongwang, Wendel, Sebastian O., Shrestha, Tej. B., Kariyawasam, Nilusha L., Kalubowilage, Madumali, Perera, Ayomi S., Pyle, Marla, Basel, Matthew T., Malalasekera, Aruni P., Manawadu, Harshi, Yu, Jing, Toledo, Yubisela, Ortega, Raquel, Thapa, Prem S., Smith, Paul E., Troyer, Deryl L., and Bossmann, Stefan H.

Subjects
chemistry
Abstract

The structure of novel binary nanosponges consisting of (cholesterol-(K/D)ₙDEVDGC)₃-trimaleimide units possessing a trigonal maleimide linker, to which either lysine (K)₂₀ or aspartic acid (D)₂₀ are tethered, has been elucidated by means of TEM. A high degree of agreement between these findings and structure predictions through explicit solvent and then coarse-grained molecular dynamics (MD) simulations has been found. Based on the nanosponges' structure and dynamics, caspase-6 mediated release of the model drug 5(6)-carboxyfluorescein has been demonstrated. Furthermore, the binary (DK20) nanosponges have been found to be virtually non-toxic in cultures of neural progenitor cells. It is of a special importance for the future development of cell-based therapies that DK20 nanosponges were taken up efficiently by leucocytes (WBC) in peripheral blood within 3 h of exposure. The percentage of live cells among the WBC was not significantly decreased by the DK20 nanosponges. In contrast to stem cell or leucocyte cell cultures, which have to be matched to the patient, autologous cells are optimal for cell-mediated therapy. Therefore, the nanosponges hold great promise for effective cell-based tumor targeting.

Published
2018

24. Peptide Nanosponges Designed for the Delivery of Perillyl Alcohol to Glioma Cells

Author

Yapa, Asanka S., primary, Shrestha, Tej B., additional, Wendel, Sebastian O., additional, Kalubowilage, Madumali, additional, Yu, Jing, additional, Wang, Hongwang, additional, Pyle, Marla, additional, Basel, Matthew T., additional, Toledo, Yubisela, additional, Ortega, Raquel, additional, Malalasekera, Aruni P., additional, Thapa, Prem S., additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2018
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25. Peptide nanosponges designed for rapid uptake by leukocytes and neural stem cells

Author

Yapa, Asanka S., primary, Wang, Hongwang, additional, Wendel, Sebastian O., additional, Shrestha, Tej. B., additional, Kariyawasam, Nilusha L., additional, Kalubowilage, Madumali, additional, Perera, Ayomi S., additional, Pyle, Marla, additional, Basel, Matthew T., additional, Malalasekera, Aruni P., additional, Manawadu, Harshi, additional, Yu, Jing, additional, Toledo, Yubisela, additional, Ortega, Raquel, additional, Thapa, Prem S., additional, Smith, Paul E., additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2018
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29. Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection

Author

Udukala, Dinusha N, primary, Wang, Hongwang, additional, Wendel, Sebastian O, additional, Malalasekera, Aruni P, additional, Samarakoon, Thilani N, additional, Yapa, Asanka S, additional, Abayaweera, Gayani, additional, Basel, Matthew T, additional, Maynez, Pamela, additional, Ortega, Raquel, additional, Toledo, Yubisela, additional, Bossmann, Leonie, additional, Robinson, Colette, additional, Janik, Katharine E, additional, Koper, Olga B, additional, Li, Ping, additional, Motamedi, Massoud, additional, Higgins, Daniel A, additional, Gadbury, Gary, additional, Zhu, Gaohong, additional, Troyer, Deryl L, additional, and Bossmann, Stefan H, additional

Published
2016
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32. Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model

Author

Basel,Matthew T, Balivada,Sivasai, Wang,Hongwang, Shrestha,Tej B, Seo,Gwi Moon, Pyle,Marla, Ayabaweera,Gayani, Dani,Raj, Koper,Olga B, Tamura,Masaaki, Chikan,Viktor, Bossmann,Stefan H, Troyer,Deryl L, Basel,Matthew T, Balivada,Sivasai, Wang,Hongwang, Shrestha,Tej B, Seo,Gwi Moon, Pyle,Marla, Ayabaweera,Gayani, Dani,Raj, Koper,Olga B, Tamura,Masaaki, Chikan,Viktor, Bossmann,Stefan H, and Troyer,Deryl L

Abstract

Matthew T Basel1, Sivasai Balivada1, Hongwang Wang2, Tej B Shrestha1, Gwi Moon Seo1, Marla Pyle1, Gayani Abayaweera2, Raj Dani2, Olga B Koper2, Masaaki Tamura1, Viktor Chikan2, Stefan H Bossmann2, Deryl L Troyer11Department of Anatomy and Physiology, College of Veterinary Medicine, 2Department of Chemistry, Kansas State University, Manhattan, KS, USAAbstract: Using magnetic nanoparticles to absorb alternating magnetic field energy as a method of generating localized hyperthermia has been shown to be a potential cancer treatment. This report demonstrates a system that uses tumor homing cells to actively carry iron/iron oxide nanoparticles into tumor tissue for alternating magnetic field treatment. Paramagnetic iron/iron oxide nanoparticles were synthesized and loaded into RAW264.7 cells (mouse monocyte/macrophage-like cells), which have been shown to be tumor homing cells. A murine model of disseminated peritoneal pancreatic cancer was then generated by intraperitoneal injection of Pan02 cells. After tumor development, monocyte/macrophage-like cells loaded with iron/iron oxide nanoparticles were injected intraperitoneally and allowed to migrate into the tumor. Three days after injection, mice were exposed to an alternating magnetic field for 20 minutes to cause the cell-delivered nanoparticles to generate heat. This treatment regimen was repeated three times. A survival study demonstrated that this system can significantly increase survival in a murine pancreatic cancer model, with an average post-tumor insertion life expectancy increase of 31%. This system has the potential to become a useful method for specifically and actively delivering nanoparticles for local hyperthermia treatment of cancer.Keywords: cytotherapy, pancreatic cancer, disseminated peritoneal carcinomatosis, targeted magnetic hyperthermia, nanoparticles

Published
2012

33. Targeting cancer therapy : using protease cleavage sequences to develop more selective and effective cancer treatments

Author

Basel, Matthew T. and Basel, Matthew T.

Abstract

This paper describes two methods for utilizing cancer associated proteases for targeting cancer therapy to the tumor. The first method is designing a drug delivery system based on liposomes that are sensitive to cancer associated proteases. Upon contact with the protease, the liposome releases its contents. The second method is designing a prodrug that is based on a porin isolated from Mycobacterium smegmatis. The porin is modified with protease consensus sequences, inhibiting its toxicity. Upon contact with the protease, the drug is activated. Protease sensitive liposomes were synthesized that were sensitive to urokinase plasminogen activator. This was done by synthesizing a cholesterol-anchored, uPA consensus-sequence-containing, acrylic acid block copolymer and using it to form a covalently bound polymer cage around the outside of a hypertonic liposome. Liposomes were synthesized that had a diameter of 136 nm. Upon addition of the polymer the diameter increased by 2.69 nm, indicating it had successfully embedded into the liposome membrane. After crosslinking with either a short peptide containing a lysine (so that it is a diamine) or ethylenediamine, the diameter increased between 5.33 nm and 14.1 nm (depending on the type and amount of the crosslinked). Fluorescence release assays showed that the polymer cage could add in excess of thirty atmospheres of osmotic pressure resistance, and, under isobaric conditions, would prevent release of much of the liposomal contents. Upon treatment with uPA, the polymer caged liposomes released a significantly larger amount of their contents making the liposomes protease sensitive. MspA was shown to be a very stable protein able to be imaged by AFM. AFM imaging demonstrated that MspA is able to form native pore structures in membranes making it a good imitator of the membrane attack complex. MspA was demonstrated to be highly cytotoxic, but poor at distinguishing between cells. Pro-MspA was synthesized by adding a hydrophilic peptide to MspA that prevents insertion. A uPA cleavage sequence embedded causes the MspA to become activated at the cancer site. This was demonstrated in tests against uPA and non-uPA producing cell lines.

Published
2010

34. Channel Blocking of MspA Revisited

Author

Perera, Ayomi S., primary, Wang, Hongwang, additional, Basel, Matthew T., additional, Pokhrel, Megh Raj, additional, Gamage, Pubudu Siyambalagoda, additional, Kalita, Mausam, additional, Wendel, Sebastian, additional, Sears, Bryan, additional, Welideniya, Dhanushi, additional, Liu, Yao, additional, Turro, Claudia, additional, Troyer, Deryl L., additional, and Bossmann, Stefan H., additional

Published
2012
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35. Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

Author

Wang, Hongwang, primary, Shrestha, Tej B, additional, Basel, Matthew T, additional, Dani, Raj Kumar, additional, Seo, Gwi-Moon, additional, Balivada, Sivasai, additional, Pyle, Marla M, additional, Prock, Heidy, additional, Koper, Olga B, additional, Thapa, Prem S, additional, Moore, David, additional, Li, Ping, additional, Chikan, Viktor, additional, Troyer, Deryl L, additional, and Bossmann, Stefan H, additional

Published
2012
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37. Human Xenografts Are Not Rejected in a Naturally Occurring Immunodeficient Porcine Line: A Human Tumor Model in Pigs

Author

Basel, Matthew T., primary, Balivada, Sivasai, additional, Beck, Amanda P., additional, Kerrigan, Maureen A., additional, Pyle, Marla M., additional, Dekkers, Jack C.M., additional, Wyatt, Carol R., additional, Rowland, Robert R.R., additional, Anderson, David E., additional, Bossmann, Stefan H., additional, and Troyer, Deryl L., additional

Published
2012
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41. Abstract LB-205: Using cell-delivered nanoparticles to cause local hyperthermia increases survival in a murine metastatic pancreatic cancer model

Author

Basel, Matthew T., primary, Balivada, Sivasai, additional, Wang, Hongwang, additional, Shrestha, Tej B., additional, Seo, Gwi Moon, additional, Pyle, Marla M., additional, Abayaweera, Gayani, additional, Dani, Raj, additional, Chikan, Viktor, additional, Bossmann, Stefan, additional, and Troyer, Deryl, additional

Published
2011
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44. Poly-N-Isopropyl-acrylamide/Acrylic Acid Copolymers for the Generation of Nanostructures on Mica Surfaces and as Hydrophobic Host Systems for the Porin MspA from Mycobacterium smegmatis

Author

Gamage, Pubudu, primary, Basel, Matthew T., additional, Lovell, Kimberly, additional, Pokhrel, Megh Raj, additional, Battle, Deletria, additional, Ito, Takashi, additional, Pavlenok, Mikhail, additional, Niederweis, Michael, additional, and Bossmann, Stefan H., additional

Published
2009
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46. Characterization of Nanostructured Surfaces Generated by Reconstitution of the Porin MspA from Mycobacterium smegmatis

Author

Wörner, Michael, primary, Lioubashevski, Oleg, additional, Basel, Matthew T., additional, Niebler, Sandra, additional, Gogritchiani, Eliso, additional, Egner, Nicole, additional, Heinz, Christian, additional, Hoferer, Jürgen, additional, Cipolloni, Michela, additional, Janik, Katharine, additional, Katz, Evgeny, additional, Braun, Andre M., additional, Willner, Itamar, additional, Niederweis, Michael, additional, and Bossmann, Stefan H., additional

Published
2007
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47. Pre-Lab Videos as a Supplemental Teaching Tool in First-Year Veterinary Gross Anatomy

Author

Hansen, Chandler, Basel, Matthew T., Curtis, Andrew, and Malreddy, Pradeep

Abstract

AbstractTo adapt to an interactive generation of learners, video resources can provide information necessary for lab preparation, describe clinical correlations, and maximize dissection time. In this study, dissection summary videos with embedded quizzes were to be viewed by K-State first-year veterinary students prior to their canine anatomy lab sessions. Videos were created using an iPhone, edited via Camtasia editing software, and uploaded to the course Canvas page. Following the conclusion of the Fall 2022 semester, final course grade, practical exam scores (exam), pre-lab video (video) time interaction, pre-lab quiz (quiz) scores, and student perception data were analyzed. Positive, statistically significant correlations were found between number of videos viewed and certain exam scores, with the strongest correlation being for the lower quartile specifically. Significant correlations were also found between average exam score and total number of videos viewed throughout the semester, and final course grade and total time spent viewing all videos. Positive, statistically significant correlations were found between average quiz score and exam score. A thematic analysis of student comments revealed videos appeared to have been a beneficial part of the course, providing students with a valuable resource for preparation, study, and increased understanding and confidence. These findings indicate that providing videos as a supplemental resource is beneficial to veterinary student learning and well perceived. This study also suggests that video views can predict lower quartile student exam score. The correlations in this study are weak, but the statistical significance depicts a positive impact on student practical exam scores.

Published
2023
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49. Channel Blocking of MspARevisited.

Author

Perera, Ayomi S., Wang, Hongwang, Basel, Matthew T., Pokhrel, Megh Raj, Gamage, Pubudu Siyambalagoda, Kalita, Mausam, Wendel, Sebastian, Sears, Bryan, Welideniya, Dhanushi, Liu, Yao, Turro, Claudia, Troyer, Deryl L., and Bossmann, Stefan H.

Published
2013
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