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1. Posttransfusion Sepsis Attributable to Bacterial Contamination in Platelet Collection Set Manufacturing Facility, United States

Author

Kracalik, Ian, Kent, Alyssa G., Villa, Carlos H., Gable, Paige, Annambhotla, Pallavi, McAllister, Gillian, Yokoe, Deborah, Langelier, Charles R., Oakeson, Kelly, Noble-Wang, Judith, Illoh, Orieji, Halpin, Alison Laufer, Eder, Anne F., and Basavaraju, Sridhar V.

Subjects
United States. Food and Drug Administration, United States. Centers for Disease Control and Prevention, Nucleotide sequencing, Genomics, DNA sequencing, Health
Abstract

In the United States, bacterial contamination of platelet blood components is well documented and largely a consequence of room temperature storage during their 5-7-day shelf life (1-3). Approximately 2.2 million [...]

Published
2023
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2. Fatal Invasive Mold Infections after Transplantation of Organs Recovered from Drowned Donors, United States, 2011-2021

Author

Wu, Karen, Annambhotla, Pallavi, Free, Rebecca J., Ritter, Jana M., Leitgeb, Brooke, Jackson, Brendan R., Toda, Mitsuru, Basavaraju, Sridhar V., and Gold, Jeremy A.W.

Subjects
Transplantation of organs, tissues, etc. -- Case studies -- Complications and side effects, Organ donors -- Case studies -- Health aspects, Drowning -- Case studies -- Health aspects, Mycoses -- Case studies -- Risk factors -- Patient outcomes, Disease transmission -- Case studies -- Risk factors, Health
Abstract

During 2011-2021, a total of 4,136 organs from 1,272 drowned donors were transplanted in the United States (1). Aspiration of water during drowning events can expose victims to environmental molds [...]

Published
2023
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3. Overview of U.S. COVID-19 vaccine safety surveillance systems

Author

Gee, Julianne, Shimabukuro, Tom T., Su, John R., Shay, David, Ryan, Margaret, Basavaraju, Sridhar V., Broder, Karen R., Clark, Matthew, Buddy Creech, C., Cunningham, Francesca, Goddard, Kristin, Guy, Harrison, Edwards, Kathryn M., Forshee, Richard, Hamburger, Tanya, Hause, Anne M., Klein, Nicola P., Kracalik, Ian, Lamer, Chris, Loran, David A., McNeil, Michael M., Montgomery, Jay, Moro, Pedro, Myers, Tanya R., Olson, Christine, Oster, Matthew E., Sharma, Andrea J., Schupbach, Ryan, Weintraub, Eric, Whitehead, Brett, and Anderson, Steven

Published
2024
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5. Second Nationwide Tuberculosis Outbreak Caused by Bone Allografts Containing Live Cells--United States, 2023

Author

Wortham, Jonathan M., Haddad, Maryam B., Stewart, Rebekah J., Annambhotla, Pallavi, Basavaraju, Sridhar V., Nabity, Scott A., Griffin, Isabel S., McDonald, Emily, Beshearse, Elizabeth M., Grossman, Marissa K., Schildknecht, Kimberly R., Calvet, Helene M., Keh, Chris E., Percak, Jeffrey M., Coloma, Myron, Shaw, Tambi, Davidson, Peter J., Smith, Shona R., Dickson, Robert P., Kaul, Daniel R., Gonzalez, Annett R., Rai, Saroj, Rodriguez, Gretchen, Morris, Sandra, Armitige, Lisa Y., Stapleton, Jessica, Lacassagne, Michael, Young, Laura R., Ariail, Kiley, Behm, Heidi, Jordan, Hannah T., Spencer, Magdalene, Nilsen, Diana M., Denison, Brenda Montoya, Burgos, Marcos, Leonard, Juliet M., Cortes, Erick, Thacker, Tyler C., Lehman, Kimberly A., Langer, Adam J., Cowan, Lauren S., Starks, Angela M., and LoBue, Philip A.

Subjects
United States. Food and Drug Administration, Nucleic acids, Homografts, Tuberculosis -- Diagnosis, Public health, Health
Abstract

Introduction On July 7, 2023, a state health department notified CDC that an otherwise healthy adult experienced symptoms of meningitis 5 weeks after spinal fusion surgery that incorporated a bone [...]

Published
2024

6. Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation

Author

Ajaimy, Maria, Al Azzi, Yorg, Annambhotla, Pallavi, Backenson, Bryon, Belden, Katherine, Colovai, Adriana, Coppock, Dagan, Du, Lydia, Estetter, Lindsey, Le, Marie, Martines, Roosecelis B., Pettengill, Matthew, Szymczak, Wendy, Vareechon, Chairut, Gould, Carolyn V, Free, Rebecca J, Bhatnagar, Julu, Soto, Raymond A, Royer, Tricia L, Maley, Warren R, Moss, Sean, Berk, Matthew A, Craig-Shapiro, Rebecca, Kodiyanplakkal, Rosy Priya L, Westblade, Lars F, Muthukumar, Thangamani, Puius, Yoram A, Raina, Amresh, Hadi, Azam, Gyure, Kymberly A, Trief, Danielle, Pereira, Marcus, Kuehnert, Matthew J, Ballen, Vennus, Kessler, Debra A, Dailey, Kimberly, Omura, Charles, Doan, Thuy, Miller, Steve, Wilson, Michael R, Lehman, Jennifer A, Ritter, Jana M, Lee, Elizabeth, Silva-Flannery, Luciana, Reagan-Steiner, Sarah, Velez, Jason O, Laven, Janeen J, Fitzpatrick, Kelly A, Panella, Amanda, Davis, Emily H, Hughes, Holly R, Brault, Aaron C, St George, Kirsten, Dean, Amy B, Ackelsberg, Joel, Basavaraju, Sridhar V, Chiu, Charles Y, and Staples, J Erin

Published
2023
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7. Nationwide tuberculosis outbreak in the USA linked to a bone graft product: an outbreak report

Author

Schwartz, Noah G, Hernandez-Romieu, Alfonso C, Annambhotla, Pallavi, Filardo, Thomas D, Althomsons, Sandy P, Free, Rebecca J, Li, Ruoran, Wyatt Wilson, W, Deutsch-Feldman, Molly, Drees, Marci, Hanlin, Emily, White, Kelly, Lehman, Kimberly A, Thacker, Tyler C, Brubaker, Scott A, Clark, Brychan, Basavaraju, Sridhar V, Benowitz, Isaac, Burton Glowicz, Janet, Cowan, Lauren S, Starks, Angela M, Bamrah Morris, Sapna, LoBue, Philip, Stewart, Rebekah J, Wortham, Jonathan M, and Haddad, Maryam B

Published
2022
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8. Francisella tularensis Transmission by Solid Organ Transplantation, 20171.

Author

Nelson, Christina A, Murua, Christian, Jones, Jefferson M, Mohler, Kelli, Zhang, Ying, Wiggins, Landon, Kwit, Natalie A, Respicio-Kingry, Laurel, Kingry, Luke C, Petersen, Jeannine M, Brown, Jennifer, Aslam, Saima, Krafft, Melissa, Asad, Shadaba, Dagher, Hikmat N, Ham, John, Medina-Garcia, Luis H, Burns, Kevin, Kelley, Walter E, Hinckley, Alison F, Annambhotla, Pallavi, Carifo, Karen, Gonzalez, Anthony, Helsel, Elizabeth, Iser, Joseph, Johnson, Michael, Fritz, Curtis L, Basavaraju, Sridhar V, and Tularemia in Transplant Recipients Investigation Team

Subjects
Tularemia in Transplant Recipients Investigation Team, Humans, Francisella tularensis, Tularemia, Kidney Transplantation, Heart Transplantation, Organ Transplantation, Sentinel Surveillance, Health Care Surveys, History, 21st Century, Middle Aged, Tissue Donors, Blood Donors, Female, Male, United States, bacteria, biological warfare, bioterrorism and preparedness, laboratory infection, prevention and control, tissue donors, transplant, transplantation, History, 21st Century, Microbiology, Clinical Sciences, Medical Microbiology, Public Health and Health Services
Abstract

In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F. tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor's residence were positive by PCR for F. tularensis subsp. tularensis (clade A2). This investigation documents F. tularensis transmission by solid organ transplantation.

Published
2019

9. Ahead of Print - Francisella tularensis Transmission by Solid Organ Transplantation, 2017 - Volume 25, Number 4—April 2019 - Emerging Infectious Diseases journal - CDC

Author

Nelson, Christina A, Murua, Christian, Jones, Jefferson M, Mohler, Kelli, Zhang, Ying, Wiggins, Landon, Kwit, Natalie A, Respicio-Kingry, Laurel, Kingry, Luke C, Petersen, Jeannine M, Brown, Jennifer, Aslam, Saima, Krafft, Melissa, Asad, Shadaba, Dagher, Hikmat N, Ham, John, Medina-Garcia, Luis H, Burns, Kevin, Kelley, Walter E, Hinckley, Alison F, Annambhotla, Pallavi, Carifo, Karen, Gonzalez, Anthony, Helsel, Elizabeth, Iser, Joseph, Johnson, Michael, Fritz, Curtis L, and Basavaraju, Sridhar V

Subjects
Biotechnology, Infectious Diseases, Organ Transplantation, Prevention, Transplantation, Kidney Disease, Renal and urogenital, Infection, Good Health and Well Being, Blood Donors, Female, Francisella tularensis, Health Care Surveys, Heart Transplantation, History, 21st Century, Humans, Kidney Transplantation, Male, Middle Aged, Sentinel Surveillance, Tissue Donors, Tularemia, Tularemia in Transplant Recipients Investigation Team, United States, bacteria, biological warfare, bioterrorism and preparedness, laboratory infection, prevention and control, tissue donors, transplant, transplantation, Clinical Sciences, Medical Microbiology, Public Health and Health Services, Microbiology
Abstract

In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F. tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor's residence were positive by PCR for F. tularensis subsp. tularensis (clade A2). This investigation documents F. tularensis transmission by solid organ transplantation.

Published
2019

10. Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source — Multiple States, 2018

Author

Jones, Sydney A, Jones, Jefferson M, Leung, Vivian, Nakashima, Allyn K, Oakeson, Kelly F, Smith, Amanda R, Hunter, Robert, Kim, Janice J, Cumming, Melissa, McHale, Eileen, Young, Pampee P, Fridey, Joy L, Kelley, Walter E, Stramer, Susan L, Wagner, Stephen J, West, F Bernadette, Herron, Ross, Snyder, Edward, Hendrickson, Jeanne E, Peaper, David R, Gundlapalli, Adi V, Langelier, Charles, Miller, Steve, Nambiar, Ashok, Moayeri, Morvarid, Kamm, Jack, Moulton-Meissner, Heather, Annambhotla, Pallavi, Gable, Paige, McAllister, Gillian A, Breaker, Erin, Sula, Erisa, Halpin, Alison Laufer, and Basavaraju, Sridhar V

Subjects
Microbiology, Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Hematology, Infectious Diseases, Sepsis, Aetiology, 2.2 Factors relating to the physical environment, Blood, Infection, Blood Platelets, Humans, Male, Platelet Transfusion, United States, General & Internal Medicine
Abstract

During May-October 2018, four patients from three states experienced sepsis after transfusion of apheresis platelets contaminated with Acinetobacter calcoaceticus-baumannii complex (ACBC) and Staphylococcus saprophyticus; one patient died. ACBC isolates from patients' blood, transfused platelet residuals, and two environmental samples were closely related by whole genome sequencing. S. saprophyticus isolates from two patients' blood, three transfused platelet residuals, and one hospital environmental sample formed two whole genome sequencing clusters. This whole genome sequencing analysis indicated a potential common source of bacterial contamination; investigation into the contamination source continues. All platelet donations were collected using apheresis cell separator machines and collection sets from the same manufacturer; two of three collection sets were from the same lot. One implicated platelet unit had been treated with pathogen-inactivation technology, and two had tested negative with a rapid bacterial detection device after negative primary culture. Because platelets are usually stored at room temperature, bacteria in contaminated platelet units can proliferate to clinically relevant levels by the time of transfusion. Clinicians should monitor for sepsis after platelet transfusions even after implementation of bacterial contamination mitigation strategies. Recognizing adverse transfusion reactions and reporting to the platelet supplier and hemovigilance systems is crucial for public health practitioners to detect and prevent sepsis associated with contaminated platelets.

Published
2019

11. West Nile Virus Transmission by Solid Organ Transplantation and Considerations for Organ Donor Screening Practices, United States

Author

Soto, Raymond A., McDonald, Emily, Annambhotla, Pallavi, Velez, Jason O., Laven, Janeen, Panella, Amanda J., Machesky, Kimberly D., White, Jennifer L., Hyun, Judie, Freuck, Emily, Habel, Janice, Oh, David, Levi, Marilyn, Hasz, Rick, Eidbo, Elling, Staples, J. Erin, Basavaraju, Sridhar V., and Gould, Carolyn V.

Subjects
West Nile fever -- Case studies -- Risk factors, Transplantation of organs, tissues, etc. -- Case studies -- Complications and side effects, Disease transmission -- Case studies -- Risk factors, Health
Abstract

West Nile virus (WNV) is the leading cause of mosquitoborne disease in the contiguous United States and is spread to humans primarily by Culex species mosquitoes (1). Transmission through solid [...]

Published
2022
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12. Rickettsia parkeri Rickettsiosis in Kidney Transplant Recipient, North Carolina, USA, 2023.

Author

Phadke, Gautam M., Gajurel, Kiran, Kasten, Jennifer, DeLeon-Carnes, Marlene, Ramos, Carmen, Karpathy, Sandor E., Gleaton, Arlyn N., Adams, Sydney N., Annambhotla, Pallavi D., Basavaraju, Sridhar V., Williams, Carl, and Paddock, Christopher D.

Subjects
KIDNEY transplantation, RICKETTSIAL diseases, RICKETTSIA, ANAPLASMA phagocytophilum, LYME disease, TICK infestations, EMERGING infectious diseases, SCIENCE education, PARVOVIRUS B19
Abstract

The article focuses on the rare occurrence of spotted fever rickettsiosis in solid organ transplant recipients, typically acquired months to years after transplantation due to tick bites. In this case in North Carolina, USA, a kidney transplant recipient developed symptoms of Rickettsia parkeri rickettsiosis shortly after surgery, presenting with fever, rash, and joint pain.

Published
2024
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13. Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States

Author

Mowla, Sanjida J., Drexler, Naomi A., Cherry, Cara C., Annambholta, Pallavi D., Kracalik, Ian T., and Basavaraju, Sridhar V.

Subjects
Anaplasmosis -- Statistics -- Risk factors, Cross infection -- Statistics -- Risk factors, Blood transfusion -- Complications and side effects -- Statistics, Disease transmission -- Risk factors -- Statistics, Nosocomial infections -- Statistics -- Risk factors, Ehrlichiosis -- Statistics -- Risk factors, Organ transplant recipients -- Health aspects -- Statistics, Health
Abstract

In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is jointly accredited by the Accreditation Council for [...]

Published
2021
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18. Suspected Legionella Transmission from a Single Donor to Two Lung Transplant Recipients--Pennsylvania, May 2022

Author

McGinnis, Shannon, Free, Rebecca J., Burnell, Jacqueline, Basavaraju, Sridhar V., Kanaskie, Trevor, Hannapel, Elizabeth J., Plipat, ottasorn, Warren, Kimberly, and Edens, Chris

Subjects
Transplantation of organs, tissues, etc. -- Health aspects, Fresh water -- Health aspects, Communicable diseases -- Health aspects, Medical care -- Quality management, Organ transplant recipients -- Health aspects, Health
Abstract

Investigation and Results In July 2022, the Pennsylvania Department of Health (PADOH) received reports of two cases of laboratory-confirmed Legionnaires disease in patients with exposure to the same Philadelphia hospital. [...]

Published
2023

20. SARS-CoV-2 Infections among Recent Organ Recipients, March-May 2020, United States

Author

Jones, Jefferson M., Kracalik, Ian, Rana, Meenakshi M., Nguyen, Ann, Keller, Brian C., Mishkin, Aaron, Hoopes, Charles, Kaleekal, Thomas, Humar, Abhinav, Vilaro, Juan, Im, Gene, Smith, Lou, Justice, April, Leaumont, Collette, Lindstrom, Stephen, Whitaker, Brett, La Hoz, Ricardo M., Michaels, Marian G., Klassen, David, Kuhnert, Wendi, and Basavaraju, Sridhar V.

Subjects
Infection control -- Evaluation, Donation of organs, tissues, etc. -- Health aspects, Health
Abstract

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been reported in organ transplant recipients, it is unclear whether SARS-CoV-2 can be transmitted from organ donors to recipients (1) [...]

Published
2021
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21. Sepsis Attributed to Bacterial Contamination of Platelets Associated with a Potential Common Source — Multiple States, 2018

Author

Jones, Sydney A., Jones, Jefferson M., Leung, Vivian, Nakashima, Allyn K., Oakeson, Kelly F., Smith, Amanda R., Hunter, Robert, Kim, Janice J., Cumming, Melissa, McHale, Eileen, Young, Pampee P., Fridey, Joy L., Kelley, Walter E., Stramer, Susan L., Wagner, Stephen J., West, F. Bernadette, Herron, Ross, Snyder, Edward, Hendrickson, Jeanne E., Peaper, David R., Gundlapalli, Adi V., Langelier, Charles, Miller, Steve, Nambiar, Ashok, Moayeri, Morvarid, Kamm, Jack, Moulton-Meissner, Heather, Annambhotla, Pallavi, Gable, Paige, McAllister, Gillian A., Breaker, Erin, Sula, Erisa, Halpin, Alison Laufer, and Basavaraju, Sridhar V.

Published
2019

27. Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation

Author

Gould, Carolyn V, primary, Free, Rebecca J, additional, Bhatnagar, Julu, additional, Soto, Raymond A, additional, Royer, Tricia L, additional, Maley, Warren R, additional, Moss, Sean, additional, Berk, Matthew A, additional, Craig-Schapiro, Rebecca, additional, Kodiyanplakkal, Rosy Priya L, additional, Westblade, Lars F, additional, Muthukumar, Thangamani, additional, Puius, Yoram A, additional, Raina, Amresh, additional, Hadi, Azam, additional, Gyure, Kymberly A, additional, Trief, Danielle, additional, Pereira, Marcus, additional, Kuehnert, Matthew J, additional, Ballen, Vennus, additional, Kessler, Debra A, additional, Dailey, Kimberly, additional, Omura, Charles, additional, Doan, Thuy, additional, Miller, Steve, additional, Wilson, Michael R, additional, Lehman, Jennifer A, additional, Ritter, Jana M, additional, Lee, Elizabeth, additional, Silva-Flannery, Luciana, additional, Reagan-Steiner, Sarah, additional, Velez, Jason O, additional, Laven, Janeen J, additional, Fitzpatrick, Kelly A, additional, Panella, Amanda, additional, Davis, Emily H, additional, Hughes, Holly R, additional, Brault, Aaron C, additional, St George, Kirsten, additional, Dean, Amy B, additional, Ackelsberg, Joel, additional, Basavaraju, Sridhar V, additional, Chiu, Charles Y, additional, Staples, J Erin, additional, Ajaimy, Maria, additional, Al Azzi, Yorg, additional, Annambhotla, Pallavi, additional, Backenson, Bryon, additional, Belden, Katherine, additional, Colovai, Adriana, additional, Coppock, Dagan, additional, Du, Lydia, additional, Estetter, Lindsey, additional, Le, Marie, additional, Martines, Roosecelis B., additional, Pettengill, Matthew, additional, Szymczak, Wendy, additional, and Vareechon, Chairut, additional

Published
2023
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28. Incomplete tissue product tracing during an investigation of a tissue-derived tuberculosis outbreak

Author

Marshall, Kristen E., primary, Free, Rebecca J., additional, Filardo, Thomas D., additional, Schwartz, Noah G., additional, Hernandez-Romieu, Alfonso C., additional, Thacker, Tyler C., additional, Lehman, Kimberly A., additional, Annambhotla, Pallavi, additional, Dupree, Peter B., additional, Glowicz, Janet Burton, additional, Scarpita, Ann M., additional, Brubaker, Scott A., additional, Czaja, Christopher A., additional, and Basavaraju, Sridhar V., additional

Published
2023
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30. Mycoplasma hominis Infections Transmitted Through Amniotic Tissue Product

Author

Novosad, Shannon A., Basavaraju, Sridhar V., Annambhotla, Pallavi, Mohr, Marika, Halpin, Alison Laufer, Foy, Linda, Chmielewski, Richard, Winchell, Jonas M., Benitez, Alvaro J., Morrison, Shatavia S., Johnson, Taccara, Crabb, Donna M., Ratliff, Amy E., Waites, Ken, and Kuehnert, Mattew J.

Published
2017

34. Transmission of Yellow Fever Vaccine Virus Through Blood Transfusion and Organ Transplantation in the USA in 2021: Report of an Investigation

Author

Gould, Carolyn V., Free, Rebecca J., Bhatnagar, Julu, Soto, Raymond A., Royer, Tricia L., Maley, Warren R., Moss, Sean, Berk, Matthew A., Craig-Shapiro, Rebecca, Kodiyanplakkal, Rosy Priya L., Westblade, Lars F., Muthukumar, Thangamani, Puius, Yoram A., Raina, Amresh, Hadi, Azam, Gyure, Kymberly A., Trief, Danielle, Pereira, Marcus, Kuehnert, Matthew J., Ballen, Vennus, Kessler, Debra A., Dailey, Kimberly, Omura, Charles, Doan, Thuy, Miller, Steve, Wilson, Michael R., Lehman, Jennifer A., Ritter, Jana M., Lee, Elizabeth, Silva-Flannery, Luciana, Reagan-Steiner, Sarah, Velez, Jason O., Laven, Janeen J., Fitzpatrick, Kelly A., Panella, Amanda, Davis, Emily H., Hughes, Holly R., Brault, Aaron C., St George, Kirsten, Dean, Amy B., Ackelsberg, Joel, Basavaraju, Sridhar V., Chiu, Charles Y., Staples, J. Erin, Gould, Carolyn V., Free, Rebecca J., Bhatnagar, Julu, Soto, Raymond A., Royer, Tricia L., Maley, Warren R., Moss, Sean, Berk, Matthew A., Craig-Shapiro, Rebecca, Kodiyanplakkal, Rosy Priya L., Westblade, Lars F., Muthukumar, Thangamani, Puius, Yoram A., Raina, Amresh, Hadi, Azam, Gyure, Kymberly A., Trief, Danielle, Pereira, Marcus, Kuehnert, Matthew J., Ballen, Vennus, Kessler, Debra A., Dailey, Kimberly, Omura, Charles, Doan, Thuy, Miller, Steve, Wilson, Michael R., Lehman, Jennifer A., Ritter, Jana M., Lee, Elizabeth, Silva-Flannery, Luciana, Reagan-Steiner, Sarah, Velez, Jason O., Laven, Janeen J., Fitzpatrick, Kelly A., Panella, Amanda, Davis, Emily H., Hughes, Holly R., Brault, Aaron C., St George, Kirsten, Dean, Amy B., Ackelsberg, Joel, Basavaraju, Sridhar V., Chiu, Charles Y., and Staples, J. Erin

Abstract

BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. We describe an investigation into the cause of encephalitis in these patients. METHODS: From Nov 7, 2021, to Feb 24, 2022, we conducted a public health investigation involving 15 agencies and medical centres in the USA. We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor. FINDINGS: We identified one read from yellow fever virus in cerebrospinal fluid from the recipient of a kidney using metagenomic next-generation sequencing. Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. Two patients recovered and two patients had no neurological recovery and died. 3 days before organ procurement, the organ donor received a blood transfusion from a donor who had received a yellow fever vaccine 6 days before blood donation. INTERPRETATION: This investigation substantiates the use of metagenomic next-generation sequencing for the broad-based detection of rare or unexpected pathogens. Health-care workers providing vaccinations should inform patients of the need to defer blood donation for at least 2 weeks after receiving a yellow fever vaccine. Despite mitigation strategies and safety interventions, a low risk of transfusion-transmitted infections remains. FUNDING: US Centers for Disease Control and Prevention (CDC), the Biomedical Advanced Research and Development Authority, and the CDC Epidemiology and Laboratory Capacity Cooperative

Published
2023

38. Suspected LegionellaTransmission from a Single Donor to Two Lung Transplant Recipients — Pennsylvania, May 2022

Author

McGinnis, Shannon, Free, Rebecca J., Burnell, Jacqueline, Basavaraju, Sridhar V., Kanaskie, Trevor, Hannapel, Elizabeth J., Plipat, Nottasorn, Warren, Kimberly, and Edens, Chris

Abstract

In July 2022, the Pennsylvania Department of Health received two reports of laboratory-confirmed Legionnaires disease in patients who had recently received lung transplants from the same donor at a single Pennsylvania hospital. The donor’s cause of death was freshwater drowning in a river, raising suspicion of potential donor-derived transmission, because Legionellabacteria naturally live in fresh water. Further investigation of patients receiving other organs from the same donor did not identify additional legionellosis cases. Health care–associated infection caused by water exposure at the hospital was also evaluated as a potential source of infection and was found to be unlikely. Hospital water quality parameter measurements collected during May–June 2022 were within expected ranges and no water disruptions were noted, although no testing for Legionellawas performed during this period. Notifiable disease data did not identify any other Legionnaires disease cases with exposure to this hospital within the 6 months before or after the two cases. Although laboratory testing did not confirm the source of recipient infections, available data suggest that the most likely source was the donor lungs. This cluster highlights the need for increased clinical awareness of possible infection with Legionellain recipients of lungs from donors who drowned in fresh water before organ recovery.

Published
2023
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39. Outcomes at least 90 days since onset of myocarditis after mRNA COVID-19 vaccination in adolescents and young adults in the USA: a follow-up surveillance study

Author

Kracalik, Ian, primary, Oster, Matthew E, additional, Broder, Karen R, additional, Cortese, Margaret M, additional, Glover, Maleeka, additional, Shields, Karen, additional, Creech, C Buddy, additional, Romanson, Brittney, additional, Novosad, Shannon, additional, Soslow, Jonathan, additional, Walter, Emmanuel B, additional, Marquez, Paige, additional, Dendy, Jeffrey M, additional, Woo, Jared, additional, Valderrama, Amy L, additional, Ramirez-Cardenas, Alejandra, additional, Assefa, Agape, additional, Campbell, M Jay, additional, Su, John R, additional, Magill, Shelley S, additional, Shay, David K, additional, Shimabukuro, Tom T, additional, Basavaraju, Sridhar V, additional, Campbell, Paula, additional, Anugwom, Chidera, additional, Arvelo Jefferson, Colenda, additional, Badger, Kimberly, additional, Bafford, Nastocia, additional, Barnes, Chandra, additional, Boles, Stephanie, additional, Collins, Emory, additional, Desai, Mitesh, additional, Dulski, Theresa, additional, Dyleski, Barbara, additional, Edwards, Kathryn, additional, Feyereisen, Melanie, additional, Gonsahn, Stephanie, additional, Gregory, Tchernavia, additional, Gunta, Jyothi, additional, Jacobs Slifka, Kara, additional, Kabore, Charlotte, additional, Kapella, Bryan K., additional, Karol, Susan, additional, Kennebrew, Kalah, additional, Kluisza, Nancy, additional, Lang, Sean, additional, Lanier Gholston, Labretta, additional, Law, Marcella, additional, Lehman, Jennifer, additional, Mazurek, Jacek M., additional, McGruder, Henraya, additional, McNamara, Kiara, additional, Moore, Maria-Luisa, additional, Moro, Pedro, additional, Moroney, John F., additional, Museru, Oidda, additional, Nale, Cassandra, additional, Neiman, Andi, additional, Newsome, Kim, additional, Odom, Erika, additional, Pantazides, Brooke, additional, Patel, Suchita, additional, Rao, Agam, additional, Reynolds, Laura, additional, Robinson, Sonya, additional, Ruberg, Frederick L., additional, Schaeffer, Tammy, additional, Solanky, Dipesh, additional, Sperling, Laurence, additional, Stanley, Toscha, additional, Sullivan, Regina, additional, Taylor, Allan, additional, Thomas, Kimberly, additional, Thompson, Shayle, additional, Tola, Jigsa, additional, Tran, Cuc H., additional, Wiersma, Steven, additional, and Works, Kimberly, additional

Published
2022
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40. Use of blood donor screening data to estimate Zika virus incidence, Puerto Rico, April-August 2016

Author

Chevalier, Michelle S., Biggerstaff, Brad J., Basavaraju, Sridhar V., Ocfemia, M. Cheryl Banez, Alsina, Jose O., Climent-Peris, Consuelo, Moseley, Robin R., Chung, Koo-Whang, Rivera-Garcia, Brenda, Bello-Pagan, Melissa, Pate, Lisa L., Galel, Susan A., Williamson, Phillip, and Kuehnert, Matthew J.

Subjects
United States. Food and Drug Administration, United States. Centers for Disease Control and Prevention, Roche Molecular Systems Inc., Blood banks -- Usage, Disease transmission -- Usage, Zika virus -- Usage, Blood donation -- Usage, Health
Abstract

Zika virus, a flavivirus transmitted primarily by Aedes aegypti mosquitoes, has rapidly spread in the Americas since it emerged in the region in 2015 (1). Although most infections are asymptomatic, [...]

Published
2017
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41. Transmission of hepatitis A virus through combined liver--small intestine--pancreas transplantation

Author

Foster, Monique A., Weil, Lauren M., Jin, Sherry, Johnson, Thomas, Hayden-Mixson, Tonya R., Khudyakov, Yury, Annambhotla, Pallavi D., Basavaraju, Sridhar V., Kamili, Saleem, Ritter, Jana M., Nelson, Noele, Mazariegos, George, Green, Michael, Himes, Ryan W., Kuhar, David T., Kuehnert, Matthew J., Miller, Jeffrey A., Wiseman, Rachel, and Moorman, Anne C.

Subjects
United States. Centers for Disease Control and Prevention, Hepatitis A -- Prevention -- Health aspects, Hepatovirus -- Prevention -- Health aspects, Disease transmission -- Prevention -- Health aspects, Medical records -- Health aspects, Infection -- Prevention -- Health aspects, Vaccination -- Health aspects, Organ transplantation -- Health aspects, Organ transplant recipients -- Health aspects, Nurses -- Health aspects, Liver -- Health aspects, RNA -- Health aspects, Health
Abstract

593-1-D Hepatitis A virus (HAV), the most common cause of viral hepatitis, is a nonenveloped RNA virus belonging to the family Picornaviridae (1,2). Approximately 1.5 million clinical cases of HAV [...]

Published
2017
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42. Three cases of neurologic syndrome caused by donor-derived microsporidiosis

Author

Smith, Rachel M., Muehlenbachs, Atis, Schaenmann, Joanna, Baxi, Sanjiv, Koo, Sophia, Blau, Dianna, Chin-Hong, Peter, Thorner, Anna R., Kuehnert, Matthew J., Wheeler, Kristina, Liakos, Alexis, Jackson, Jonathan W., Benedict, Theresa, da Silva, Alexandre J., Ritter, Jana M., Rollin, Dominique, Metcalfe, Maureen, Goldsmith, Cynthia S., Visvesvara, Govinda S., Basavaraju, Sridhar V., and Zaki, Sherif

Subjects
United States. Centers for Disease Control and Prevention, Diseases -- California -- Health aspects, Type 2 diabetes -- Health aspects, Kidney transplantation -- Health aspects, Liver -- Health aspects, Encephalitis -- Health aspects, Health, American Medical Association
Abstract

Each year in the United States, [approximately equal to] 30,000 solid organ transplants are performed (1). It is estimated that 0.3%-2.0% of transplants may be complicated by donor-derived infection, most [...]

Published
2017
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43. Updated U.S. Public Health Service Guideline for Testing of Transplant Candidates Aged <12 Years for Infection with HIV, Hepatitis B Virus, and Hepatitis C Virus--United States, 2022

Author

Free, Rebecca J., Levi, Marilyn E., Bowman, James S., Bixler, Danae, Brooks, John T., Buchacz, Kate, Moorman, Anne, Berger, James, and Basavaraju, Sridhar V.

Subjects
United States. Department of Health and Human Services -- Service enhancement, United States. Health Resources and Services Administration -- Service enhancement, HIV (Viruses) -- Health aspects, Transplantation of organs, tissues, etc. -- Health aspects, Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Hepatitis C virus -- Health aspects, Infection -- Health aspects, Disease transmission -- Health aspects, Public health -- Health aspects, Hepatitis B -- Health aspects, Hepatitis B virus -- Health aspects, Health
Abstract

The U.S. Public Health Service (PHS) has periodically published recommendations about reducing the risk for transmission of HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) through solid organ [...]

Published
2022

45. Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Through Solid Organ Transplantation and Outcomes of Coronavirus Disease 2019 Among Recent Transplant Recipients

Author

Free, Rebecca J, primary, Annambhotla, Pallavi, additional, La Hoz, Ricardo M, additional, Danziger-Isakov, Lara, additional, Jones, Jefferson M, additional, Wang, Lijuan, additional, Sankthivel, Senthil, additional, Levi, Marilyn E, additional, Michaels, Marian G, additional, Kuhnert, Wendi, additional, Klassen, David, additional, Basavaraju, Sridhar V, additional, and Kracalik, Ian T, additional

Published
2022
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46. Notes from the Field:Tuberculosis Outbreak Linked to a Contaminated Bone Graft Product Used in Spinal Surgery — Delaware, March–June 2021

Author

Li, Ruoran, Wilson, W. Wyatt, Schwartz, Noah G., Hernandez-Romieu, Alfonso C., Glowicz, Janet, Hanlin, Emily, Taylor, Malikah, Pelkey, Heather, Briody, Carol A., Gireesh, Lija, Eskander, Mark, Lingenfelter, Kenneth, Althomsons, Sandy P., Stewart, Rebekah J., Free, Rebecca, Annambhotla, Pallavi, Basavaraju, Sridhar V., Wortham, Jonathan M., Morris, Sapna Bamrah, Benowitz, Isaac, Haddad, Maryam B., Hong, Rick, and Drees, Marci

Subjects
Adult, medicine.medical_specialty, Health (social science), Tuberculosis, Epidemiology, Health, Toxicology and Mutagenesis, Disease Outbreaks, Health Information Management, Humans, Medicine, Product (category theory), Aged, Aged, 80 and over, Bone Transplantation, business.industry, General surgery, Outbreak, General Medicine, Middle Aged, Delaware, medicine.disease, Spine, United States, Spinal surgery, Product Recalls and Withdrawals, Centers for Disease Control and Prevention, U.S, business, Notes from the Field
Published
2021

48. Donor‐derived tuberculosis among solid organ transplant recipients in the United States—2008 to 2018

Author

Malinis, Maricar, primary, La Hoz, Ricardo M., additional, Vece, Gabriel, additional, Annambhotla, Pallavi, additional, Aslam, Saima, additional, Basavaraju, Sridhar V., additional, Bucio, Jamie, additional, Danziger‐Isakov, Lara, additional, Florescu, Diana F., additional, Jones, Jefferson M., additional, Rana, Meenakshi, additional, Wolfe, Cameron R., additional, and Michaels, Marian G., additional

Published
2022
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