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8. Phytochemical Screening, GCMS Profiling, In Vitro Antioxidant, In Vivo Acute Toxicity, and Hepatoprotective Activity of Cleome simplicifolia Bioactive Metabolites against Paracetamol-Intoxicated Wister Albino Rats

Author

Shaikh, Heena Yaqub, primary, Niazi, Shaik Kalimulla, additional, Bepari, Asmatanzeem, additional, Assiri, Rasha Assad, additional, Rudrappa, Muthuraj, additional, Chavhan, Mahantesh Shitaram, additional, Basavarajappa, Dhanyakumara Shivapoojar, additional, and Agadi, Shekappa Ningappa, additional

Published
2023
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9. Efficacy of Penicillium limosum Strain AK-7 Derived Bioactive Metabolites on Antimicrobial, Antioxidant, and Anticancer Activity against Human Ovarian Teratocarcinoma (PA-1) Cell Line

Author

Basavarajappa, Dhanyakumara Shivapoojar, primary, Niazi, Shaik Kalimulla, additional, Bepari, Asmatanzeem, additional, Assiri, Rasha Assad, additional, Hussain, Syed Arif, additional, Muzaheed, Muzaheed, additional, Nayaka, Sreenivasa, additional, Hiremath, Halaswamy, additional, Rudrappa, Muthuraj, additional, Chakraborty, Bidhayak, additional, and Hugar, Anil, additional

Published
2023
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10. Unveiling the Pharmacological Significance of Marine Streptomyces violaceusniger KS20: Isolation, Characterization, and Assessment of Its Biomedical Applications

Author

Chakraborty, Bidhayak, primary, Shashiraj, Kariyellappa Nagaraja, additional, Kumar, Raju Suresh, additional, Bhat, Meghashyama Prabhakara, additional, Basavarajappa, Dhanyakumara Shivapoojar, additional, Almansour, Abdulrahman I., additional, Perumal, Karthikeyan, additional, and Nayaka, Sreenivasa, additional

Published
2023
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12. Investigation of In Vitro Anticancer and Apoptotic Potential of Biofabricated Silver Nanoparticles from Cardamine hirsuta (L.) Leaf Extract against Caco-2 Cell Line

Author

Math, Halaswamy Hire, primary, Shashiraj, Kariyellappa Nagaraja, additional, Kumar, Raju Suresh, additional, Rudrappa, Muthuraj, additional, Bhat, Meghashyama Prabhakara, additional, Basavarajappa, Dhanyakumara Shivapoojar, additional, Almansour, Abdulrahman I., additional, Perumal, Karthikeyan, additional, and Nayaka, Sreenivasa, additional

Published
2023
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13. Phytochemical Screening, GCMS Profiling, In Vitro Antioxidant, In Vivo Acute Toxicity, and Hepatoprotective Activity of Cleome simplicifolia Bioactive Metabolites against Paracetamol-Intoxicated Wister Albino Rats.

Author

Shaikh, Heena Yaqub, Niazi, Shaik Kalimulla, Bepari, Asmatanzeem, Assiri, Rasha Assad, Rudrappa, Muthuraj, Chavhan, Mahantesh Shitaram, Basavarajappa, Dhanyakumara Shivapoojar, and Agadi, Shekappa Ningappa

Subjects
ACRYLIC acid, METABOLITES, ALANINE aminotransferase, ASPARTATE aminotransferase, ALBINISM, ALKALINE phosphatase
Abstract

The current study aimed to appraise extracts of Cleome simplicifolia (Cambess.) Hook. f. and Thomson leaves for chemical integrant and biological activities. In this study, different extracts of leaves were estimated for qualitative phytochemical screening, identification of functional groups, mineral content, and phyto-compounds and assessed for in vitro antioxidant and in vivo acute toxicity and hepatoprotective activity antagonistic toward paracetamol-intoxicated Wister albino rats. The results of the qualitative phytochemical assessment of the leaf extracts (acetone, methanol, and distilled water) exhibited the occurrence of useful metabolites. A Fourier transform infrared analysis confirmed the occurrence of O-H, N-H, C=C, S=O, C-O, C-N, C-Cl, and C-Br at 3367.14, 2920.79, 2850.32, 1631.04, 1384.59, 1168.64, 1063.78, 824.78, and 615.25 cm−1 wavelengths, whereas energy-dispersive X-ray showed the existence of carbon, oxygen, magnesium, aluminum, silicon, phosphorus, sulfur, chlorine, potassium, and calcium elements in the leaf, respectively. Thereafter, a gas chromatography–mass spectroscopy analysis unveiled the diverse volatile compounds in the methanolic leaf extracts, namely n-Heptyl acrylate—18.87%, undecane—17.49%, 2-Propenoic acid, 3-(3,4-dimethoxyphenyl)-, (E)—11.40%, Neophytadiene—11.02%, n-Hexadecanoic acid—10.78%, Glafenin—10.09%, Decane—7.45%, Phytol—6.0%, Benzene, (1-methyldodecyl)—3.48%, and 4-Cyclohexyl-1-butanol—3.41%, respectively. An analysis of in vitro antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl assay of methanolic leaf extract revealed elevated levels of antioxidant ability at 20 (46.18%), 40 (53.83%), 60 (66.64%), 80 (74.03%), and 100 (85.05%) μg/mL. In addition, in vivo acute toxicity determination proved that the methanolic leaf extract was innocuous and caused no mortality at 72 mg, 78 mg, or 82 mg/kg b.wt. doses. The methanolic leaf extracts' in vivo hepatoprotective activity against paracetamol revealed significant efficacy at 50 and 100 mg/kg b.wt. via reduction of aspartate transaminase, alanine transaminase, alkaline phosphatase, bilirubin, and cholesterol (serum blood biochemical markers) followed by an enhancement in superoxide dismutase, catalase, and glutathione (liver antioxidants) with lipid peroxidation depletion compared with the normal group rats. From the investigated study, it was concluded that the C. simplicifolia leaf are a potential source for the isolation of biologically active phyto-compounds and have the ability to prevent liver damage by paracetamol induction, where the hepatic restoration ability is indexed to its in vivo and in vitro antioxidant ability, which might be the result of its chemical constituents. [ABSTRACT FROM AUTHOR]

Published
2024
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14. GC-MS Based Characterization, Antibacterial, Antifungal and Anti-Oncogenic Activity of Ethyl Acetate Extract of Aspergillus niger Strain AK-6 Isolated from Rhizospheric Soil

Author

Niazi, Shaik Kalimulla, primary, Basavarajappa, Dhanyakumara Shivapoojar, additional, Kumaraswamy, Sushma Hatti, additional, Bepari, Asmatanzeem, additional, Hiremath, Halaswamy, additional, Nagaraja, Shashiraj Kariyellappa, additional, Rudrappa, Muthuraj, additional, Hugar, Anil, additional, Cordero, Mary Anne Wong, additional, and Nayaka, Sreenivasa, additional

Published
2023
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15. Rotheca serrata Flower Bud Extract Mediated Bio-Friendly Preparation of Silver Nanoparticles: Their Characterizations, Anticancer, and Apoptosis Inducing Ability against Pancreatic Ductal Adenocarcinoma Cell Line

Author

Shashiraj, Kariyellappa Nagaraja, primary, Nayaka, Sreenivasa, additional, Kumar, Raju Suresh, additional, Kantli, Gireesh Babu, additional, Basavarajappa, Dhanyakumara Shivapoojar, additional, Gunagambhire, Pooja Vidyasagar, additional, Almansour, Abdulrahman I., additional, and Perumal, Karthikeyan, additional

Published
2023
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16. Biocontrol of CercosporaLeaf Spot Disease and Enhancement of Defense Response in Vigna radiata(L.) R. Wilczek (Mung Bean) Plants Using Bioformulation of Endophytic Streptomycessp

Author

Basavarajappa, Dhanyakumara Shivapoojar, Kumar, Raju Suresh, Bhat, Meghashyama Prabhakara, Almansour, Abdulrahman I., Perumal, Karthikeyan, and Nayaka, Sreenivasa

Abstract

Enhancement of disease resistance using beneficial microbes is one of the promising and eco-friendly strategies for disease management in crop plants. The talcum formulation of endophytic Streptomycessp. strain SND-2 (SND-2), isolated from the plant Cleome rutidosperma(C. rutidosperma), was demonstrated as a biotic defense elicitor in mung bean plants against Cercosporaleaf spot disease (CLS). The strain SND-2 exhibited significant antifungal potential against three selected phytopathogens, i.e., Cercospora canescens, Fusarium oxysporum,and Sclerotium rolfsii, with 69.45 ± 1.2, 47.16 ± 1.17, and 67.73 ± 1.06% of inhibition in dual culture assays. Further, the strain SND-2 exhibited positive extracellular enzymatic activities such as cellulase, amylase, glucanase, and gelatinase. Secondary screening of antifungal potential through a poisoned food method resulted in a significant inhibition of mycelial growth of tested phytopathogens. GC–MS analysis revealed strong antifungal metabolites. Consequently, application of a talcum formulation of the SND-2 strain resulted in increased growth parameters under greenhouse conditions against CLS infection. The induction of systematic resistance (ISR) study showed accelerated histochemical deposition in mung bean leaves with 82.4 ± 1.29, 47.31 ± 1.76, and 77.40 ± 0.84% of lignin, hydrogen peroxide, and phenol depositions. The SND-2 formulation exhibited the biochemical defense through enhanced defense enzymatic activities such as phenylalanine ammonia-lyase, β-1,3-glucanase, peroxidase, polyphenol oxidase, and lipoxygenase. The results hinted that Streptomycessp. strain SND-2 has potential to control CLS disease and protect the mung bean plants through enhanced ISR under CLS biotic stress and that it can be a sustainable strategy for disease protection.

Published
2023
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17. Biofunctionalized silver nanoparticles synthesized from Passiflora vitifolia leaf extract and evaluation of its antimicrobial, antioxidant and anticancer activities

Author

Basavarajappa, Dhanyakumara Shivapoojar, primary, Kumar, Raju Suresh, additional, Almansour, Abdulrahman I., additional, Chakraborty, Bidhayak, additional, Bhat, Meghashyama Prabhakara, additional, Nagaraja, Shashiraj Kariyellappa, additional, Hiremath, Halaswamy, additional, Perumal, Karthikeyan, additional, and Nayaka, Sreenivasa, additional

Published
2022
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18. Bio-inspired silver nanoparticles from Artocarpus lakoocha fruit extract and evaluation of their antibacterial activity and anticancer activity on human prostate cancer cell line

Author

Bhat, Meghashyama Prabhakara, primary, Kumar, Raju Suresh, additional, Rudrappa, Muthuraj, additional, Basavarajappa, Dhanyakumara Shivapoojar, additional, Swamy, Pallavi Sathyanarayana, additional, Almansour, Abdulrahman I., additional, Perumal, Karthikeyan, additional, and Nayaka, Sreenivasa, additional

Published
2022
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19. Plumeria alba-Mediated Green Synthesis of Silver Nanoparticles Exhibits Antimicrobial Effect and Anti-Oncogenic Activity against Glioblastoma U118 MG Cancer Cell Line

Author

Rudrappa, Muthuraj, primary, Rudayni, Hassan Ahmed, additional, Assiri, Rasha Assad, additional, Bepari, Asmatanzeem, additional, Basavarajappa, Dhanyakumara Shivapoojar, additional, Nagaraja, Shashiraj Kariyellappa, additional, Chakraborty, Bidhayak, additional, Swamy, Pallavi Sathyanarayana, additional, Agadi, Shekappa Ningappa, additional, Niazi, Shaik Kalimulla, additional, and Nayaka, Sreenivasa, additional

Published
2022
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20. Efficacy of antibiotic sensitivity and antimicrobial activity of Streptomyces cinereoruber RSA-14 isolated from rhizosphere soil of Alternanthera sessilis (L.) R. Br. ex DC

Author

Hiremath Halaswamy, Nayaka Sreenivasa, Basavarajappa Dhanyakumara Shivapoojar, Chakraborty Bidhayak, Swamy Pallavi Sathyanarayan, Bhat Meghashyama Prabhakara, Airodagi Dattatraya, Nagaraja Shashiraj Kareyallappa, Murigennavar Meenakshi Shivanandagouda, and Rudrappa Muthuraj

Subjects
Rhizosphere, Antibiotic sensitivity, Botany, Alternanthera sessilis, Plant Science, Streptomyces cinereoruber, Biology, Antimicrobial, biology.organism_classification, Agronomy and Crop Science, General Biochemistry, Genetics and Molecular Biology, Food Science
Published
2020

21. Cytotoxicity and Apoptosis Induced Tumor Suppressing Potential of Silver Nanoparticles Derived from Passiflora Vitifolia Leaf Extract Against RAW-264.7 Cell Line

Author

Basavarajappa, Dhanyakumara Shivapoojar, primary, Kumar, Raju Suresh, additional, Almansour, Abdulrahman I., additional, Chakraborty, Bidhayak, additional, Bhat, Meghashyama Prabhakara, additional, Nagarajaa, Shashiraj Kariyellappa, additional, Math, Halaswamy Hire, additional, Perumal, Karthikeyan, additional, and Nayaka, Sreenivasa, additional

Published
2021
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22. Antimicrobial and Enzymatic potential of Streptomyces sp. KAS-1 isolated from the microbiologically unexplored estuary of Kali river ecosystem

Author

Nayaka, Sreenivasa, primary, Nagaraja, Shashiraj Kareyallappa, additional, Chakraborty, Bidhayak, additional, Bhat, Meghashyama Prabhakara, additional, Swamy, Pallavi Sathyanarayana, additional, Airodagi, Dattatraya, additional, Hiremath, Halaswamy, additional, Rudrappa, Muthuraj, additional, Basavarajappa, Dhanyakumara Shivapoojar, additional, and Pednekar, Anusha Rohidas, additional

Published
2020
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