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15. HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2

Author

De Re, V, De Zorzi, M, Caggiari, L, Lauletta, G, Tornesello, ML, Fognani, E, Miorin, M, Racanelli, V, Quartuccio, L, Gragnani, L, Russi, S, Pavone, F, Ghersetti, M, Costa, EG, Casarin, P, Bomben, R, Mazzaro, C, Basaglia, G, Berretta, M, Vaccher, E, Izzo, F, Buonaguro, FM, De Vita, S, Zignego, AL, De Paoli, P, Dolcetti, R, De Re, V, De Zorzi, M, Caggiari, L, Lauletta, G, Tornesello, ML, Fognani, E, Miorin, M, Racanelli, V, Quartuccio, L, Gragnani, L, Russi, S, Pavone, F, Ghersetti, M, Costa, EG, Casarin, P, Bomben, R, Mazzaro, C, Basaglia, G, Berretta, M, Vaccher, E, Izzo, F, Buonaguro, FM, De Vita, S, Zignego, AL, De Paoli, P, and Dolcetti, R

Abstract

To explore the relationship between innate immunity and hepatitis C Virus (HCV) in determining the risk of cirrhosis (CIR), hepatocellular carcinoma (HCC), mixed cryoglobulinemia syndrome (MCS) and non-Hodgkin lymphoma (NHL), we investigated the impact of the toll-like receptor-2 (TLR2) and interleukin-28B (IL28B) genetic variants. TLR2 -174 del variant was associated with TLR2 expression and with specific downstream molecules that drive the expression of different interleukins; rs12979860 Il28B was important in response to interferon-treatment and in spontaneous clearance of HCV. The risk for liver and lymphoproliferative diseases in HCV progression was clarified by stratifying 862 HCV-positive patients into groups based on liver (CIR, HCC) and lymphoproliferative HCV-related diseases (MCS, NHL) and compared with chronic HCV (CHC) infection. Analysis of TLR2-IL28B haplotypes showed an association of wild type haplotype with the lymphoproliferative diseases (OR 1.77, p = 0.029) and a slight increase in HCV viral load (HR 1.38, p = 0.054). Wild type haplotype (TLR2 ins/ins- IL28B C/C) was also found associated with older age in patients with an hepatic diseases (in CIR and in HCC p = 0.038 and p = 0.020, respectively) supporting an effect of innate immunity in the liver disease progression. TLR2 and IL28B polymorphisms in combination showed a role in the control of HCV viral load and different HCV disease progression.

Published
2016

19. Creazione di un documento regionale per la gestione dell'infezione da Acinetobacter baumannii

Author

Dal Cin, M, Arnoldo, L, Cocconi, R, Fabro, R, Faruzzo, A, Bassetti, Matteo, Cadeo, B, Crapis, M., Lugano, M, DELLA ROCCA, Giorgio, Pea, F, Giacomazzi, D, Luzzati, R, Silvestri, L, Basaglia, G, Busetti, M, Camporese, A, Chittaro, M, Sartor, A, Scarparo, C, Benedetti, G, Farneti, F, Gregoretti, B, Montesi, C, Forcella, V, Agnoletto, A. P, Fanzutto, A, and Brusaferro, Silvio

Published
2012

23. OC.02.4 DIFFERENT PROTEIN EXPRESSION AND GENES PATTERNS OF HELICOBATER PYLORI IN PATHOLOGICAL DISORDERS OF THE GASTRIC MUCOSA

Author

De Re, V., primary, Repetto, O., additional, Zanussi, S., additional, Garziera, M., additional, De Zorzi, M., additional, Casarotto, M., additional, Giacomini, S., additional, Basaglia, G., additional, Maiero, S., additional, Toffoli, G., additional, Canzonieri, V., additional, De Paoli, P., additional, and Cannizzaro, R., additional

Published
2012
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37. Catheter-Related Bacteremia Due to Kocuria kristinaein a Patient with Ovarian Cancer

Author

Basaglia, G., Carretto, E., Barbarini, D., Moras, L., Scalone, S., Marone, P., and De Paoli, P.

Abstract

ABSTRACTWe report on the first case of a catheter-related recurrent bacteremia caused by Kocuria kristinae, a gram-positive microorganism belonging to the family Micrococcaceae, in a 51-year-old woman with ovarian cancer. This unusual pathogen may cause opportunistic infections in patients with severe underlying diseases.

Published
2002
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39. A multicenter study on central venous catheter-associated infections in Italy

Author

Donelli, G., Paoli, P., Fadda, G., Piero Marone, Nicoletti, G., Varaldo, P. E., Bacchiocchi, S., Manso, E., Pruzzo, C., Sambo, G., Basaglia, G., Cicco, M., Moras, L., Agodi, A., Gianninò, V., Messina, C., Mezzatesta, M., Russo, G., Stefani, S., Abbaneo, E., Carretto, E., Monzillo, V., Rindi, S., Speziale, P., Visai, L., Baldassarri, L., Barbieri, M., Di Carlo, V., Di Rosa, R., Francolini, I., Ginnetti, F., Leone, F., Mazzella, P., Marconi, W., and Rossi, A.

Subjects
Catheterization, Central Venous, medicine.medical_specialty, medicine.medical_treatment, Colony Count, Microbial, Biology, Polymerase Chain Reaction, Bacterial Adhesion, Immunocompromised Host, antibiotic-resistance, biofilms, bloodstream infections, catheter quality, central venous catheters, medical device-related infections, microbial colonization, scanning electron microscopy, Catheters, Indwelling, medicine, Humans, Microbial colonization, Pharmacology (medical), Host protein, Pharmacology, Cross Infection, Bacteria, Drug Resistance, Microbial, Anti-Bacterial Agents, Surgery, Clinical microbiology, Infectious Diseases, Italy, Oncology, Multicenter study, Biofilms, Microscopy, Electron, Scanning, Central venous catheter
Abstract

In a 1-year multicenter study the microbial colonization of 1154 central venous catheters (CVCs) was investigated. Catheters explanted either from immunocompromised or immunocompetent patients were collected and analyzed by five clinical microbiology laboratories located in Ancona, Aviano, Catania, Pavia and Rome, Italy.A further aim was to investigate, by scanning electron microscopy, the features of currently used catheters, both new and explanted from patients, analyzing their surface quality, the influence of the host protein biofilm on their microbial colonization, the modifications caused by their permanence in the body and the relationship between these factors and the occurrence of infections.

47. Gut microbiota trajectory in pediatric patients undergoing hematopoietic SCT

Author

Giulia Basaglia, Daniele Zama, Andrea Pession, Marco Severgnini, Jessica Fiori, Clelia Peano, Elena Biagi, Marco Candela, Riccardo Masetti, Manuela Centanni, Simone Rampelli, Patrizia Brigidi, Roberto Gotti, Claudia Nastasi, Silvia Turroni, G. De Bellis, Clarissa Consolandi, Biagi, E, Zama, D, Nastasi, C, Consolandi, C, Fiori, J, Rampelli, S, Turroni, S, Centanni, M, Severgnini, M, Peano, C, de Bellis, G, Basaglia, G, Gotti, R, Masetti, R, Pession, A, Brigidi, P, and Candela, M

Subjects
Hematological disorders, 16S, medicine.medical_treatment, aGVHD, bone marrow transplantation, microbiome, Graft vs Host Disease, Hematopoietic stem cell transplantation, Gut flora, digestive system, Microbial ecosystem, immune system diseases, hemic and lymphatic diseases, Acute graft versus host disease, medicine, Humans, Transplantation, Homologous, Immune homeostasis, Microbiome, Longitudinal Studies, Child, Transplantation, biology, business.industry, Hematopoietic Stem Cell Transplantation, Hematology, hematopoietic stem cell transplantation, acute graft-versus-host disease, gut microbiota, immune homeostasis, biology.organism_classification, Gastrointestinal Microbiome, Haematopoiesis, surgical procedures, operative, NGS, Immunology, Acute Disease, Female, business, therapeutics
Abstract

Acute GvHD (aGvHD) is the main complication of hematopoietic SCT (HSCT) during the treatment of hematological disorders. We carried out the first longitudinal study to follow the gut microbiota trajectory, from both the phylogenetic and functional points of view, in pediatric patients undergoing HSCT. Gut microbiota trajectories and short-chain fatty acid production profiles were followed starting from before HSCT and through the 3–4 months after transplant in children developing and not developing aGvHD. According to our findings, HSCT procedures temporarily cause a structural and functional disruption of the gut microbial ecosystem, describing a trajectory of recovery during the following 100 days. The onset of aGvHD is associated with specific gut microbiota signatures both along the course of gut microbiota reconstruction immediately after transplant and, most interestingly, prior to HSCT. Indeed, in pre-HSCT samples, non-aGvHD patients showed higher abundances of propionate-producing Bacteroidetes, highly adaptable microbiome mutualists that showed to persist during the HSCT-induced ecosystem disruption. Our data indicate that structure and temporal dynamics of the gut microbial ecosystem can be a relevant factor for the success of HSCT and opens the perspective to the manipulation of the pre-HSCT gut microbiota configuration to favor mutualistic persisters with immunomodulatory properties in the gut.

Published
2014

48. Different Protein Expression and Genes Patterns of Helicobater Pylori in Pathological Disorders of the Gastric Mucosa

Author

Cannizzaro, Renato, Paoli, Paolo, Vincenzo Canzonieri, Toffoli, Giuseppe, Maiero, Stefania, Basaglia, Giancarlo, Giacomini, Sendy, Casarotto, Mariateresa, Zorzi, Mariangela, Garziera, Marica, Zanussi, Stefania, Repetto, Ombretta, Re, Valli, De Re, V, Repetto, O, Zanussi, S, Garziera, M, Zorzi, M, Casarotto, M, Giacomini, S, Basaglia, G, Maiero, S, Toffoli, G, Canzonieri, V, De Paoli, P, and Cannizzaro, R

Published
2012

49. Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts

Author

Alessandro Tossi, Monica Benincasa, Marco Scocchi, Giancarlo Basaglia, Donatella Nobili, Renato Gennaro, Sabrina Pacor, Marina Busetti, Benincasa, Monica, Scocchi, Marco, Pacor, Sabrina, Tossi, Alessandro, Nobili, D, Basaglia, G, Busetti, M, and Gennaro, Renato

Subjects
Microbiology (medical), Antifungal Agents, Cell Membrane Permeability, host defence, Swine, clinical isolates, medicine.medical_treatment, Molecular Sequence Data, Antimicrobial peptides, Peptide, Microbial Sensitivity Tests, Biology, pathogenic fungi, Microbiology, Cathelicidin, antifungals, cathelicidin, innate immunity, immunocompromised patients, chemistry.chemical_compound, clinical isolate, Cathelicidins, Candida albicans, medicine, Animals, Humans, Pharmacology (medical), Amino Acid Sequence, Propidium iodide, Pharmacology, Cryptococcus neoformans, chemistry.chemical_classification, Candidiasis, Cryptococcosis, biology.organism_classification, Infectious Diseases, chemistry, Indolicidin, Cattle, antifungal, Antimicrobial Cationic Peptides
Abstract

Objectives: To investigate the in vitro antifungal activity of the structurally different cathelicidin peptides SMAP-29, BMAP-27, BMAP-28, protegrin-1 (PG-1) and indolicidin. Methods: The in vitro antifungal and fungicidal activities of these antimicrobial peptides were respectively assessed via MIC determinations and killing kinetics assays. The effects of the peptides on membrane permeabilization and morphology were evaluated by flow cytometry, intracellular ATP release measurements and scanning electron microscopy. Results: All five peptides showed a potent but differential antifungal activity against more than 70 clinical isolates belonging to over 20 different species of pathogenic fungi; some of which are resistant to amphotericin B and azoles. The MIC values of the peptides ranged between 0.5 and 32 mM, with PG-1 being the most effective and having the widest spectrum of activity. Filamentous fungi were instead found to be scarcely susceptible to the action of these cathelicidin peptides. All these cathelicidins rapidly killed Candida albicans and Cryptococcus neoformans cells in a dose- and time-dependent manner. The rapid uptake of propidium iodide into treated cells and morphological alterations apparent on their cellular surfaces suggest a killing mechanism based on membrane permeabilization and damage. Conclusions: This study indicates that these five structurally varied host defence peptides are all endowed with the capacity to inactivate a number of fungal pathogens, irrespectively of their resistance to antifungal drugs, and suggests they might be potentially useful leads for the development of novel fungicidal agents.

Published
2006

50. The Management of Recurrent Urinary Tract Infection: Non-Antibiotic Bundle Treatment.

Author

Venturini S, Reffo I, Avolio M, Basaglia G, Del Fabro G, Callegari A, Tonizzo M, Sabena A, Rondinella S, Mancini W, Conte C, and Crapis M

Subjects
Humans, Female, Middle Aged, Adult, Recurrence, Vaccinium macrocarpon chemistry, Aged, Urinary Tract Infections drug therapy, Urinary Tract Infections microbiology, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents administration & dosage, Quality of Life, Mannose, Probiotics administration & dosage, Probiotics therapeutic use
Abstract

Recurrent urinary tract infections (rUTIs) are a common condition with high morbidity and negatively impact the quality of life. They account for approximately 25% of all antibiotic prescriptions and are a public health concern in an era of increasing multidrug-resistant organisms (MDROs). Several non-antibiotic treatment strategies have been tried to curb antimicrobial use, and many are effective to some degree, but no experience testing multimodal interventions. We created a "care bundle" consisting of behavioral interventions, vaginal and oral probiotics, D-mannose, and cranberry to be followed for six months. We enrolled women with rUTIs over three years. Changes in urinary tract infections, antibiotic use, chronic symptoms, and quality of life were compared in the six months before and after participation in the study. Forty-seven women were enrolled in the study, six of whom were excluded from the final analysis. We observed a 76% reduction in urinary tract infections (p < 0.001) and a reduction in total antibiotic exposure of more than 90% (p < 0.001); all chronic symptoms showed a trend toward reduction. Adherence to the bundle was high (87.2%). Overall, 80.5% of women experienced an improvement in their quality of life. In our experience, a bundle protocol is effective in reducing recurrences and antimicrobial use in a cohort of women with rUTIs and results in a subjective improvement in chronic symptoms and quality of life. Further research with larger sample size is needed to confirm these findings., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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