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2. Assessing West Nile virus (WNV) and Usutu virus (USUV) exposure in bird ringers in the Netherlands: a high-risk group for WNV and USUV infection?

Author

de Bellegarde de Saint Lary, Chiara, Kasbergen, Louella M.R., Bruijning-Verhagen, Patricia C.J.L., van der Jeugd, Henk, Chandler, Felicity, Hogema, Boris M., Zaaijer, Hans L., van der Klis, Fiona R.M., Barzon, Luisa, de Bruin, Erwin, ten Bosch, Quirine, Koopmans, Marion P.G., Sikkema, Reina S., and Visser, Leo G.

Published
2023
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5. Antibody-based assay discriminates Zika virus infection from other flaviviruses

Author

Balmaseda, Angel, Stettler, Karin, Medialdea-Carrera, Raquel, Collado, Damaris, Jin, Xia, Zambrana, José Victor, Jaconi, Stefano, Cameroni, Elisabetta, Saborio, Saira, Rovida, Francesca, Percivalle, Elena, Ijaz, Samreen, Dicks, Steve, Ushiro-Lumb, Ines, Barzon, Luisa, Siqueira, Patricia, Brown, David WG, Baldanti, Fausto, Tedder, Richard, Zambon, Maria, de Filippis, AM Bispo, Harris, Eva, and Corti, Davide

Subjects
Vector-Borne Diseases, Biotechnology, Emerging Infectious Diseases, Rare Diseases, Immunization, Biodefense, Prevention, Vaccine Related, Infectious Diseases, Infection, Good Health and Well Being, Adolescent, Antibodies, Blocking, Antibodies, Monoclonal, Antibodies, Viral, Child, Child, Preschool, Cross Reactions, Dengue, Diagnosis, Differential, Enzyme-Linked Immunosorbent Assay, Flavivirus Infections, Humans, Prospective Studies, Sensitivity and Specificity, Viral Nonstructural Proteins, Zika Virus, Zika Virus Infection, Zika, serology, flaviviruses, dengue, ELISA
Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged recently as a global health threat, causing a pandemic in the Americas. ZIKV infection mostly causes mild disease, but is linked to devastating congenital birth defects and Guillain-Barré syndrome in adults. The high level of cross-reactivity among flaviviruses and their cocirculation has complicated serological approaches to differentially detect ZIKV and dengue virus (DENV) infections, accentuating the urgent need for a specific and sensitive serological test. We previously generated a ZIKV nonstructural protein 1 (NS1)-specific human monoclonal antibody, which we used to develop an NS1-based competition ELISA. Well-characterized samples from RT-PCR-confirmed patients with Zika and individuals exposed to other flavivirus infections or vaccination were used in a comprehensive analysis to determine the sensitivity and specificity of the NS1 blockade-of-binding (BOB) assay, which was established in laboratories in five countries (Nicaragua, Brazil, Italy, United Kingdom, and Switzerland). Of 158 sera/plasma from RT-PCR-confirmed ZIKV infections, 145 (91.8%) yielded greater than 50% inhibition. Of 171 patients with primary or secondary DENV infections, 152 (88.9%) scored negative. When the control group was extended to patients infected by other flaviviruses, other viruses, or healthy donors (n = 540), the specificity was 95.9%. We also analyzed longitudinal samples from DENV-immune and DENV-naive ZIKV infections and found inhibition was achieved within 10 d postonset of illness and maintained over time. Thus, the Zika NS1 BOB assay is sensitive, specific, robust, simple, low-cost, and accessible, and can detect recent and past ZIKV infections for surveillance, seroprevalence studies, and intervention trials.

Published
2017

6. West Nile virus spread in Europe:Phylogeographic pattern analysis and key drivers

Author

Lu, Lu, Zhang, Feifei, Munnink, Bas B.Oude, Munger, Emmanuelle, Sikkema, Reina S., Pappa, Styliani, Tsioka, Katerina, Sinigaglia, Alessandro, Dal Molin, Emanuela, Shih, Barbara B., Günther, Anne, Pohlmann, Anne, Ziegler, Ute, Beer, Martin, Taylor, Rachel A., Bartumeus, Frederic, Woolhouse, Mark, Aarestrup, Frank M., Barzon, Luisa, Papa, Anna, Lycett, Samantha, Koopmans, Marion P.G., Lu, Lu, Zhang, Feifei, Munnink, Bas B.Oude, Munger, Emmanuelle, Sikkema, Reina S., Pappa, Styliani, Tsioka, Katerina, Sinigaglia, Alessandro, Dal Molin, Emanuela, Shih, Barbara B., Günther, Anne, Pohlmann, Anne, Ziegler, Ute, Beer, Martin, Taylor, Rachel A., Bartumeus, Frederic, Woolhouse, Mark, Aarestrup, Frank M., Barzon, Luisa, Papa, Anna, Lycett, Samantha, and Koopmans, Marion P.G.

Abstract

Background West Nile virus (WNV) outbreaks in birds, humans, and livestock have occurred in multiple areas in Europe and have had a significant impact on animal and human health. The patterns of emergence and spread of WNV in Europe are very different from those in the US and understanding these are important for guiding preparedness activities. Methods We mapped the evolution and spread history of WNV in Europe by incorporating viral genome sequences and epidemiological data into phylodynamic models. Spatially explicit phylogeographic models were developed to explore the possible contribution of different drivers to viral dispersal direction and velocity. A "skygrid-GLM"approach was used to identify how changes in environments would predict viral genetic diversity variations over time. Findings Among the six lineages found in Europe, WNV-2a (a sub-lineage of WNV-2) has been predominant (accounting for 73% of all sequences obtained in Europe that have been shared in the public domain) and has spread to at least 14 countries. In the past two decades, WNV- 2a has evolved into two major co-circulating clusters, both originating from Central Europe, but with distinct dynamic history and transmission patterns. WNV-2a spreads at a high dispersal velocity (88km/yr-215 km/yr) which is correlated to bird movements. Notably, amongst multiple drivers that could affect the spread of WNV, factors related to land use were found to strongly influence the spread of WNV. Specifically, the intensity of agricultural activities (defined by factors related to crops and livestock production, such as coverage of cropland, pasture, cultivated and managed vegetation, livestock density) were positively associated with both spread direction and velocity. In addition, WNV spread direction was associated with high coverage of wetlands and migratory bird flyways. Conclusion Our results suggest that-in addition to ecolo

Published
2024

7. 424.4: The Protection From CMV Infection in Solid Organ Transplants Is Highly Dependent on CMV T-Cell Specific Immunity And Type of Organ Transplant

Author

Saldan, Alda, Mengoli, Carlo, Sgarabotto, Dino, Alessi, Marianna, Gambino, Antonio, Bonfante, Luciana, Burra, Patrizia, Marchini, Francesco, Boccagni, Patrizia, Toscano, Giuseppe, Feltrin, Giuseppe, Silvestre, Cristina, Russo, Francesco P, Furian, Lucrezia, Loy, Monica, Barzon, Luisa, Sturniolo, Giacomo, Cillo, Umberto, Rigotti, Paolo, Rea, Federico, and Abate, Davide

Published
2022
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8. West Nile Virus Emergence in Germany 2019: Looking for Hidden Human West Nile Virus Infections.

Author

Lachmann, Raskit, Domingo, Cristina, Frank, Christina, Ochs, Andreas, Pauly, Andreas Karl, Weber-Schehl, Marijke, Schmidt, Michael, Tonn, Torsten, Müller, Thomas H., Barzon, Luisa, Sinigaglia, Alessandro, Esquevin, Sarah, Preußel, Karina, and Offergeld, Ruth

Subjects
WEST Nile virus, COVID-19, WEST Nile fever, TICK-borne encephalitis viruses, IMMUNOGLOBULIN M, ENZYME-linked immunosorbent assay, IMMUNOGLOBULIN G
Abstract

Background: Autochthonous human West Nile virus (WNV) infections were notified in the infectious disease surveillance system in Germany in 2018 for the first time and every year since then. Since clinically apparent infections are infrequent, we conducted two studies to investigate subclinical infections of this emerging disease in Germany in 2019 to detect infections not visible to surveillance based on symptomatic infections: limited-scope blood donor testing and a serosurvey among employees at two Berlin zoos with a history of demonstrated WNV infections in animals. Methods: For the zoo study, employees of the two zoos in Berlin were invited to participate in the study in late 2019. Blood samples were drawn and tested for the presence of antibodies (immunoglobulin M [IgM] and immunoglobulin G [IgG]) against WNV, and two other flaviviruses present in Germany: Usutu virus and Tick-borne encephalitis virus (TBEV). For the study in blood donors, four blood establishments with collection sites in regions with documented WNV-infected animals in 2018 and 2019 participated in the study. All donations in these regions were tested for WNV genome from July to November 2019. Results: In the enzyme-linked immunosorbent assay, none of the 70 tested zoo employees were WNV IgM-positive, 8 were WNV IgG-positive, additional 2 participants had equivocal results. All 10 were negative in the virus neutralization test (VNT) for WNV, but positive in the VNT for TBEV. None of the 4273 samples from blood donors tested in areas with WNV-infected animals was positive for WNV-RNA. Conclusion: Our results indicate that WNV circulation in Germany, though clearly documented in animals in 2019, apparently affected very few humans. Still areas with WNV-positive animals remain risk areas for human infection as well. [ABSTRACT FROM AUTHOR]

Published
2024
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9. West Nile virus spread in Europe: Phylogeographic pattern analysis and key drivers

Author

Lu, Lu, primary, Zhang, Feifei, additional, Oude Munnink, Bas B., additional, Munger, Emmanuelle, additional, Sikkema, Reina S., additional, Pappa, Styliani, additional, Tsioka, Katerina, additional, Sinigaglia, Alessandro, additional, Dal Molin, Emanuela, additional, Shih, Barbara B., additional, Günther, Anne, additional, Pohlmann, Anne, additional, Ziegler, Ute, additional, Beer, Martin, additional, Taylor, Rachel A., additional, Bartumeus, Frederic, additional, Woolhouse, Mark, additional, Aarestrup, Frank M., additional, Barzon, Luisa, additional, Papa, Anna, additional, Lycett, Samantha, additional, and Koopmans, Marion P. G., additional

Published
2024
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11. Collaborative national multicenter for the identification of conversion factors from copies/mL to international units/mL for the normalization of HCMV DNA load

Author

Sidoti, Francesca, Piralla, Antonio, Costa, Cristina, Scarasciulli, Maria Luisa, Calvario, Agata, Conaldi, Pier Giulio, Paba, Pierpaolo, Perno, Carlo Federico, Gaeta, Aurelia, Antonelli, Guido, Sodano, Giuseppe, Santangelo, Rosaria, Sanguinetti, Maurizio, Vatteroni, Maria Linda, Barzon, Luisa, Palù, Giorgio, Abbate, Isabella, Capobianchi, Maria Rosaria, Piccirilli, Giulia, Lazzarotto, Tiziana, Baldanti, Fausto, and Cavallo, Rossana

Published
2019
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12. Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAs

Author

Lavezzari, Denise, primary, Mori, Antonio, additional, Pomari, Elena, additional, Deiana, Michela, additional, Fadda, Antonio, additional, Bertoli, Luca, additional, Sinigaglia, Alessandro, additional, Riccetti, Silvia, additional, Barzon, Luisa, additional, Piubelli, Chiara, additional, Delledonne, Massimo, additional, Capobianchi, Maria Rosaria, additional, and Castilletti, Concetta, additional

Published
2023
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13. Reply to Fontaine

Author

Barzon, Luisa, Percivalle, Elena, Pacenti, Monia, Rovida, Francesca, Zavattoni, Maurizio, Del Bravo, Paola, Cattelan, Anna Maria, Palù, Giorgio, and Baldanti, Fausto

Published
2018

16. Dengue Virus IgM Serotyping by ELISA with Recombinant Mutant Envelope Proteins

Author

Rockstroh, Alexandra, Barzon, Luisa, Kumbukgolla, Widuranga, Su, Hoang Xuan, Lizarazo, Erley, Vincenti-Gonzalez, Maria Fernanda, Tami, Adriana, Ornelas, Alice M.M., Aguiar, Renato Santana, Cadar, Daniel, Schmidt-Chanasit, Jonas, and Ulbert, Sebastian

Subjects
Patient care -- Analysis -- Health aspects, Disease susceptibility -- Analysis -- Health aspects, Infection -- Analysis -- Health aspects, Dengue virus -- Analysis -- Health aspects, Enzyme-linked immunosorbent assay -- Analysis -- Health aspects, Medical research -- Analysis -- Health aspects, Travelers, Shock, Hemorrhagic fevers, Health
Abstract

Dengue virus (DENV) is an arthropodborne flavivirus that is endemic in tropical and subtropical regions, causing hundreds of millions of infections annually (1). It is subdivided into 4 serotypes, DENV-1-4. [...]

Published
2019
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18. Epidemiology, surveillance and diagnosis of Usutu virus infection in the EU/EEA, 2012 to 2021

Author

Angeloni, Giorgia, primary, Bertola, Michela, additional, Lazzaro, Elena, additional, Morini, Matteo, additional, Masi, Giulia, additional, Sinigaglia, Alessandro, additional, Trevisan, Marta, additional, Gossner, Céline M., additional, Haussig, Joana M., additional, Bakonyi, Tamas, additional, Capelli, Gioia, additional, and Barzon, Luisa, additional

Published
2023
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19. Arbovirus researchers unite: expanding genomic surveillance for an urgent global need

Author

Wallau, Gabriel Luz, primary, Abanda, Ngu Njei, additional, Abbud, Adriano, additional, Abdella, Saro, additional, Abera, Adugna, additional, Ahuka-Mundeke, Steve, additional, Falconi-Agapito, Francesca, additional, Alagarasu, Kalichamy, additional, Ariën, Kevin K, additional, Ayres, Constancia Flávia Junqueira, additional, Barzon, Luisa, additional, Bonney, Joseph Humphrey Kofi, additional, Boumbaly, Sanaba, additional, Buchy, Philippe, additional, Cao-Lormeau, Van-Mai, additional, Chem, Yu Kie, additional, Cardenas, Paul A, additional, Castillo, Andres E, additional, Delfraro, Adriana, additional, Devine, Gregor, additional, Duong, Veasna, additional, Dupont-Rouzeyrol, Myrielle, additional, Fadeev, Artem V, additional, Fajardo, Alvaro, additional, Diaz, Luis Adrián, additional, Gómez, Lara Ferrero, additional, Gudo, Eduardo Samo, additional, Gutierrez-Bugallo, Gladys, additional, Hapuarachchi, Hapuarachchige Chanditha, additional, Heraud, Jean-Michel, additional, Hibberd, Martin L, additional, Inlamea, Osvaldo Frederico, additional, Jasmin, Nik, additional, Kydyshov, Kalysbek, additional, Kelly, Maria Ezekiely, additional, Khan, Salim, additional, Komissarov, Andrey B, additional, Leaungwutiwong, Pornsawan, additional, Leguia, Mariana, additional, Lustig, Yaniv, additional, Maciel-de-Freitas, Rafael, additional, Malavige, Gathsaurie Neelika, additional, Martinez, Alexander A, additional, Mendoza, Maria L, additional, Mo, Luong T, additional, Moreno, Brechla, additional, Mwasi, Lydia, additional, Naveca, Felipe Gomes, additional, NG, Lee Ching, additional, Njouom, Richard, additional, Nogueira, Mauricio Lacerda, additional, Ntoumi, Francine, additional, Nzoyikorera, Nehemie, additional, Parra, Barbara A, additional, Pichardo, Mauricio Vázquez, additional, Privaldos, Kristine Joy Ragual, additional, Rivero, Ricardo, additional, Rojas, Alejandra María, additional, Salvato, Richard Steiner, additional, Sasmono, R Tedjo, additional, Schmidt-Chanasit, Jonas, additional, Simon-Loriere, Etienne, additional, Sy, Ava Kristy Dy, additional, Talledo-Albujar, Michael, additional, Tizhe, Daniel Thakuma, additional, Toloshovich, Usenbaev Nurbolot, additional, Tran, Vi Thuy, additional, Troupin, Cécile, additional, Kayiwa, John Timothy, additional, van den Hurk, Andrew, additional, Vasilakis, Nikolaos, additional, Weldemariam, Atsbeha Gebreegziabxier, additional, Yacoub, Sophie, additional, Zaini, Zainun, additional, and Wallau, Gabriel Luz, additional

Published
2023
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20. Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients

Author

Gervais, Adrian, primary, Rovida, Francesca, additional, Avanzini, Maria Antonietta, additional, Croce, Stefania, additional, Marchal, Astrid, additional, Lin, Shih-Ching, additional, Ferrari, Alessandro, additional, Thorball, Christian W., additional, Constant, Orianne, additional, Le Voyer, Tom, additional, Philippot, Quentin, additional, Rosain, Jérémie, additional, Angelini, Micol, additional, Pérez Lorenzo, Malena, additional, Bizien, Lucy, additional, Achille, Cristian, additional, Trespidi, Francesca, additional, Burdino, Elisa, additional, Cassaniti, Irene, additional, Lilleri, Daniele, additional, Fornara, Chiara, additional, Sammartino, José Camilla, additional, Cereda, Danilo, additional, Marrocu, Chiara, additional, Piralla, Antonio, additional, Valsecchi, Chiara, additional, Ricagno, Stefano, additional, Cogo, Paola, additional, Neth, Olaf, additional, Marín-Cruz, Inés, additional, Pacenti, Monia, additional, Sinigaglia, Alessandro, additional, Trevisan, Marta, additional, Volpe, Andrea, additional, Marzollo, Antonio, additional, Conti, Francesca, additional, Lazzarotto, Tiziana, additional, Pession, Andrea, additional, Viale, Pierluigi, additional, Fellay, Jacques, additional, Ghirardello, Stefano, additional, Aubart, Mélodie, additional, Ghisetti, Valeria, additional, Aiuti, Alessandro, additional, Jouanguy, Emmanuelle, additional, Bastard, Paul, additional, Percivalle, Elena, additional, Baldanti, Fausto, additional, Puel, Anne, additional, MacDonald, Margaret R., additional, Rice, Charles M., additional, Rossini, Giada, additional, Murray, Kristy O., additional, Simonin, Yannick, additional, Nagy, Anna, additional, Barzon, Luisa, additional, Abel, Laurent, additional, Diamond, Michael S., additional, Cobat, Aurélie, additional, Zhang, Shen-Ying, additional, Casanova, Jean-Laurent, additional, and Borghesi, Alessandro, additional

Published
2023
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21. Cervical cancer screening in women vaccinated against human papillomavirus infection: Recommendations from a consensus conference

Author

Barca, Alessandra, Barzon, Luisa, Baussano, Iacopo, Berliri, Carla, Bonanni, Paolo, Boselli, Fausto, Boveri, Sara, Buonaguro, Franco Maria, Burroni, Elena, Carillo, Giuseppe, Carretta, Elisa, Chini, Francesco, Confortini, Massimo, Palma, Paolo Dalla, Declich, Silvia, Del Mistro, Annarosa, Del Sole, Anna Maria, Ferretti, Stefano, Gabutti, Giovanni, Gargiulo, Franco, Giambi, Cristina, Iannazzo, Stefania, Iossa, Anna, Levi, Miriam, Lillo, Flavia, Maccalini, Vincenzo, Mangia, Maria Luisa, Mariani, Luciano, Naldoni, Carlo, Ocello, Cristina, Paci, Eugenio, Pellegrini, Antonella, Perino, Antonio, Pezzarossi, Annamaria, Pilia, Massimo, Placidi, Antonio, Pompa, Maria Grazia, Russo, Francesca, Sandri, Maria Teresa, Sani, Cristina, Scalisi, Aurora, Schiboni, Maria Luisa, Segnan, Nereo, Sideri, Mario, Spinillo, Arsenio, Taddei, Gian Luigi, Tornesello, Maria Lina, Venturelli, Francesco, Vocaturo, Amina, Zorzi, Manuel, Giorgi Rossi, Paolo, Carozzi, Francesca, Federici, Antonio, Ronco, Guglielmo, Zappa, Marco, and Franceschi, Silvia

Published
2017
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25. Human cytomegalovirus and Epstein–Barr virus infections occurring early after transplantation are risk factors for antibody-mediated rejection in heart transplant recipients

Author

Saldan, Alda, primary, Mengoli, Carlo, additional, Sgarabotto, Dino, additional, Fedrigo, Marny, additional, Angelini, Annalisa, additional, Feltrin, Giuseppe, additional, Gambino, Antonio, additional, Gerosa, Gino, additional, Barzon, Luisa, additional, and Abate, Davide, additional

Published
2023
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26. ACE2 Receptor and TMPRSS2 Protein Expression Patterns in the Human Brainstem Reveal Anatomical Regions Potentially Vulnerable to SARS-CoV-2 Infection

Author

Emmi, Aron, primary, Tushevski, Aleksandar, additional, Sinigaglia, Alessandro, additional, Barbon, Silvia, additional, Sandre, Michele, additional, Stocco, Elena, additional, Macchi, Veronica, additional, Antonini, Angelo, additional, Barzon, Luisa, additional, Porzionato, Andrea, additional, and De Caro, Raffaele, additional

Published
2023
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27. Role of the Extracytoplasmic Function Sigma Factor SigE in the Stringent Response of Mycobacterium tuberculosis

Author

Baruzzo, Giacomo, primary, Serafini, Agnese, additional, Finotello, Francesca, additional, Sanavia, Tiziana, additional, Cioetto-Mazzabò, Laura, additional, Boldrin, Francesca, additional, Lavezzo, Enrico, additional, Barzon, Luisa, additional, Toppo, Stefano, additional, Provvedi, Roberta, additional, Manganelli, Riccardo, additional, and Di Camillo, Barbara, additional

Published
2023
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28. Assessing West Nile virus (WNV) and Usutu virus (USUV) exposure in bird ringers in the Netherlands:a high-risk group for WNV and USUV infection?

Author

de Bellegarde de Saint Lary, Chiara, Kasbergen, Louella M.R., Bruijning-Verhagen, Patricia C.J.L., van der Jeugd, Henk, Chandler, Felicity, Hogema, Boris M., Zaaijer, Hans L., van der Klis, Fiona R.M., Barzon, Luisa, de Bruin, Erwin, ten Bosch, Quirine, Koopmans, Marion P.G., Sikkema, Reina S., Visser, Leo G., de Bellegarde de Saint Lary, Chiara, Kasbergen, Louella M.R., Bruijning-Verhagen, Patricia C.J.L., van der Jeugd, Henk, Chandler, Felicity, Hogema, Boris M., Zaaijer, Hans L., van der Klis, Fiona R.M., Barzon, Luisa, de Bruin, Erwin, ten Bosch, Quirine, Koopmans, Marion P.G., Sikkema, Reina S., and Visser, Leo G.

Abstract

Introduction: In 2020, the first Dutch West Nile virus (WNV) infected birds were detected through risk-targeted surveillance of songbirds. Retrospective testing of patients with unexplained neurological disease revealed human WNV infections in July and August 2020. Bird ringers are highly exposed to mosquito bites and possibly avian excrements during ringing activities. This study therefore investigates whether bird ringers are at higher risk of exposure to WNV and Usutu virus (USUV). Methods: Dutch bird ringers were asked to provide a single serum sample (May – September 2021) and to fill out a survey. Sera were screened by protein microarray for presence of specific IgG against WNV and USUV non-structural protein 1 (NS1), followed by focus reduction virus neutralization tests (FRNT). Healthcare workers (2009–2010), the national immunity cohort (2016–2017) and blood donors (2021) were used as control groups without this occupational exposure. Results: The majority of the 157 participating bird ringers was male (132/157, 84%) and the median age was 62 years. Thirty-seven participants (37/157, 23.6%) showed WNV and USUV IgG microarray signals above background, compared to 6.4% (6/94) in the community cohort and 2.1% (2/96) in blood donors (p < 0.01). Two seroreactive bird ringers were confirmed WNV or USUV positive by FRNT. The majority of seroreactive bird ringers travelled to EU countries with reported WNV human cases (30/37, 81%) (p = 0.07). No difference was observed between bird ringers with and without previous yellow fever vaccination. Discussion: The higher frequency of WNV and/or USUV IgG reactive bird ringers indicates increased flavivirus exposure compared to the general population, suggesting that individuals with high-exposure professions may be considered to complement existing surveillance systems. However, the complexity of serological interpretation in relation to location-specific exposure (including travel), and antibody cross-reactivity, rem

Published
2023

29. Assessing West Nile virus (WNV) and Usutu virus (USUV) exposure in bird ringers in the Netherlands: a high-risk group for WNV and USUV infection?

Author

dLAB Biobank, Epi Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, Child Health, JC onderzoeksprogramma Infectieziekten, de Bellegarde de Saint Lary, Chiara, Kasbergen, Louella M.R., Bruijning-Verhagen, Patricia C.J.L., van der Jeugd, Henk, Chandler, Felicity, Hogema, Boris M., Zaaijer, Hans L., van der Klis, Fiona R.M., Barzon, Luisa, de Bruin, Erwin, ten Bosch, Quirine, Koopmans, Marion P.G., Sikkema, Reina S., Visser, Leo G., dLAB Biobank, Epi Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, Child Health, JC onderzoeksprogramma Infectieziekten, de Bellegarde de Saint Lary, Chiara, Kasbergen, Louella M.R., Bruijning-Verhagen, Patricia C.J.L., van der Jeugd, Henk, Chandler, Felicity, Hogema, Boris M., Zaaijer, Hans L., van der Klis, Fiona R.M., Barzon, Luisa, de Bruin, Erwin, ten Bosch, Quirine, Koopmans, Marion P.G., Sikkema, Reina S., and Visser, Leo G.

Published
2023

30. A specific anti‐COVID‐19 BNT162b2 vaccine‐induced early innate immune signature positively correlates with the humoral protective response in healthy and multiple sclerosis vaccine recipients

Author

Severa, Martina, primary, Rizzo, Fabiana, additional, Sinigaglia, Alessandro, additional, Ricci, Daniela, additional, Etna, Marilena Paola, additional, Cola, Gaia, additional, Landi, Doriana, additional, Buscarinu, Maria Chiara, additional, Valdarchi, Catia, additional, Ristori, Giovanni, additional, Riccetti, Silvia, additional, Piubelli, Chiara, additional, Palmerini, Pierangela, additional, Rosato, Antonio, additional, Gobbi, Federico, additional, Balducci, Stefano, additional, Marfia, Girolama Alessandra, additional, Salvetti, Marco, additional, Barzon, Luisa, additional, and Coccia, Eliana Marina, additional

Published
2023
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31. Four-Year Follow-Up of the Maternal Immunological, Virological and Clinical Settings of a 36-Year-Old Woman Experiencing Primary Cytomegalovirus Infection Leading to Intrauterine Infection

Author

Forner, Gabriella, primary, Saldan, Alda, additional, Mengoli, Carlo, additional, Pizzi, Sara, additional, Fedrigo, Marny, additional, Gussetti, Nadia, additional, Visentin, Silvia, additional, Angelini, Annalisa, additional, Cosmi, Erich, additional, Barzon, Luisa, additional, and Abate, Davide Antonio, additional

Published
2022
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32. TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by NTRK Fusions

Author

Cappellesso, Rocco, primary, Nicolè, Lorenzo, additional, Del Fiore, Paolo, additional, Barzon, Luisa, additional, Sinigaglia, Alessandro, additional, Riccetti, Silvia, additional, Franco, Renato, additional, Zito Marino, Federica, additional, Munari, Giada, additional, Zamuner, Carolina, additional, Cavallin, Francesco, additional, Sbaraglia, Marta, additional, Galuppini, Francesca, additional, Bassetto, Franco, additional, Alaibac, Mauro, additional, Chiarion-Sileni, Vanna, additional, Piccin, Luisa, additional, Benna, Clara, additional, Fassan, Matteo, additional, Mocellin, Simone, additional, and Dei Tos, Angelo Paolo, additional

Published
2022
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35. Rapid spread of a new West Nile virus lineage 1 associated with increased risk of neuroinvasive disease during a large outbreak in northern Italy, 2022: One Health analysis

Author

Barzon, Luisa, Pacenti, Monia, Montarsi, Fabrizio, Fornasiero, Diletta, Gobbo, Federica, Quaranta, Erika, Monne, Isabella, Fusaro, Alice, Volpe, Andrea, Sinigaglia, Alessandro, Riccetti, Silvia, Molin, Emanuela Dal, Satto, Sorsha, Lisi, Vittoria, Gobbi, Federico, Galante, Silvia, Feltrin, Giuseppe, Valeriano, Valerio, Favero, Laura, Russo, Francesca, Mazzucato, Matteo, Bortolami, Alessio, Mulatti, Paolo, Terregino, Calogero, and Capelli, Gioia

Subjects
West Nile virus, bird, fever, lineage, mosquito, neuroinvasive disease
Abstract

A new strain of WNV lineage 1 (WNV - 1) emerged in the Veneto Region, northern Italy, in 2021, eight years after the last outbreak of WNV - 1 in Italy. The virus, which co-circulates with WNV-2, has become endemic in the Region, where, in 2022, most human cases of neuroinvasive disease (WNND) reported in Europe have occurred.Comparative analysis of the epidemiology and clinical presentation of WNV-1 and WNV-2 infection in humans, as well as the temporal and geographic distribution of WNV-1 and WNV-2 among wild birds and Culex pipiens mosquitoes in Veneto, from May 16th to August 21st, 2022, to determine if the high number of WNND cases was associated with WNV-1.As of August 21st, 2022, 222 human cases of WNV infection were confirmed by molecular testing, including 103 with fever (WNF) and 119 with WNND. WNV lineage was determined in 201 (90.5%) cases, comprising 138 WNV-1 and 63 WNV-2 infections. During the same period, 35 blood donors tested positive, including 30 in whom WNV lineage was determined (13 WNV-1 and 17 WNV-2). Comparative analysis of the distribution of WNV-1 and WNV-2 infections among WNND cases, WNF cases and WNV-positive blood donors showed that patients with WNND were more likely to have WNV-1 infection than blood donors (odds ratio 3.44; 95% CI 95% 1.54 to 8.24; p = 0.0043). As observed in humans, in wild birds WNV-1 had higher infectious rate (IR) and showed a more rapid expansion than WNV-2. At variance, the distribution of the two lineages was more even in mosquitoes, but with a trend of rapid increase of WNV-1 IR over WNV-2.Comparative analysis of WNV-1 vs WNV-2 infection in humans, wild birds, and mosquitos showed a rapid expansion of WNV-1 and suggested that WNV-1 infected patients might have an increased risk to develop severe disease.

Published
2022

36. Rapid increase in neuroinvasive West Nile virus infections in humans, Italy, July 2022

Author

Riccardo, Flavia, Bella, Antonino, Monaco, Federica, Ferraro, Federica, Petrone, Daniele, Mateo-Urdiales, Alberto, Andrianou, Xanthi D, Del Manso, Martina, Venturi, Giulietta, Fortuna, Claudia, Di Luca, Marco, Severini, Francesco, Caporali, Maria Grazia, Morelli, Daniela, Iapaolo, Federica, Pati, Ilaria, Lombardini, Letizia, Bakonyi, Tamas, Alexandra, Olivia, Pezzotti, Patrizio, Perrotta, Maria Gabriella, Maraglino, Francesco, Rezza, Giovanni, Palamara, Anna Teresa, and Barzon, Luisa

Subjects
Italy, One Health, West Nile virus, epidemiology, outbreaks, public health policy, surveillance, vector-borne infections, viral infections, Animals, Birds, Humans, Mosquito Vectors, Culicidae, West Nile Fever, Epidemiology, Public Health, Environmental and Occupational Health, Virology
Abstract

As in 2018, when a large West Nile virus (WNV) epidemic occurred, the 2022 vector season in Italy was marked by an early onset of WNV circulation in mosquitoes and birds. Human infections were limited until early July, when we observed a rapid increase in the number of cases. We describe the epidemiology of human infections and animal and vector surveillance for WNV and compare the more consolidated data of June and July 2022 with the same period in 2018.

Published
2022

37. West Nile Virus spread in Europe - phylogeographic pattern analysis and key drivers

Author

Lu, Lu, primary, Zhang, Feifei, additional, Oude Munnink, Bas B., additional, Munger, Emmanuelle, additional, Sikkema, Reina S., additional, Pappa, Styliani, additional, Tsioka, Katerina, additional, Sinigaglia, Alessandro, additional, Dal Molin, Emanuela, additional, Shih, Barbara B., additional, Günther, Anne, additional, Pohlmann, Anne, additional, Beer, Martin, additional, Taylor, Rachel A., additional, Bartumeus, Frederic, additional, Woolhouse, Mark, additional, Aarestrup, Frank M., additional, Barzon, Luisa, additional, Papa, Anna, additional, Lycett, Samantha, additional, and Koopmans, Marion P. G., additional

Published
2022
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38. Rapid spread of a new West Nile virus lineage 1 associated with increased risk of neuroinvasive disease during a large outbreak in Italy in 2022

Author

Barzon, Luisa, primary, Pacenti, Monia, additional, Montarsi, Fabrizio, additional, Fornasiero, Diletta, additional, Gobbo, Federica, additional, Quaranta, Erika, additional, Monne, Isabella, additional, Fusaro, Alice, additional, Volpe, Andrea, additional, Sinigaglia, Alessandro, additional, Riccetti, Silvia, additional, Dal Molin, Emanuela, additional, Satto, Sorsha, additional, Lisi, Vittoria, additional, Gobbi, Federico, additional, Galante, Silvia, additional, Feltrin, Giuseppe, additional, Valeriano, Valerio, additional, Favero, Laura, additional, Russo, Francesca, additional, Mazzucato, Matteo, additional, Bortolami, Alessio, additional, Mulatti, Paolo, additional, Terregino, Calogero, additional, and Capelli, Gioia, additional

Published
2022
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44. Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

Author

Giannella, Alessandra, primary, Riccetti, Silvia, additional, Sinigaglia, Alessandro, additional, Piubelli, Chiara, additional, Razzaboni, Elisa, additional, Di Battista, Piero, additional, Agostini, Matteo, additional, Dal Molin, Emanuela, additional, Manganelli, Riccardo, additional, Gobbi, Federico, additional, Ceolotto, Giulio, additional, and Barzon, Luisa, additional

Published
2022
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45. Early start of seasonal transmission and co-circulation of West Nile virus lineage 2 and a newly introduced lineage 1 strain, northern Italy, June 2022

Author

Barzon, Luisa, primary, Montarsi, Fabrizio, additional, Quaranta, Erika, additional, Monne, Isabella, additional, Pacenti, Monia, additional, Michelutti, Alice, additional, Toniolo, Federica, additional, Danesi, Patrizia, additional, Marchetti, Giulio, additional, Gobbo, Federica, additional, Sinigaglia, Alessandro, additional, Riccetti, Silvia, additional, Dal Molin, Emanuela, additional, Favero, Laura, additional, Russo, Francesca, additional, and Capelli, Gioia, additional

Published
2022
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46. COVID-19 Neuropathology: evidence for SARS-CoV-2 invasion of Human Brainstem Nuclei

Author

Emmi, Aron, primary, Rizzo, Stefania, additional, Barzon, Luisa, additional, Sandre, Michele, additional, Carturan, Elisa, additional, Sinigaglia, Alessandro, additional, Riccetti, Silvia, additional, della Barbera, Mila, additional, Boscolo-Berto, Rafael, additional, Cocco, Patrizia, additional, Macchi, Veronica, additional, Antonini, Angelo, additional, De Gaspari, Monica, additional, Basso, Cristina, additional, De Caro, Raffaele, additional, and Porzionato, Andrea, additional

Published
2022
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50. Mosquito alert:leveraging citizen science to create a GBIF mosquito occurrence dataset

Author

Južnič-Zonta, Živko, Sanpera-Calbet, Isis, Eritja, Roger, Palmer, John R B, Escobar, Agustí, Garriga, Joan, Oltra, Aitana, Richter-Boix, Alex, Schaffner, Francis, Della Torre, Alessandra, Miranda, Miguel Ángel, Koopmans, Marion, Barzon, Luisa, Bartumeus Ferre, Frederic, Južnič-Zonta, Živko, Sanpera-Calbet, Isis, Eritja, Roger, Palmer, John R B, Escobar, Agustí, Garriga, Joan, Oltra, Aitana, Richter-Boix, Alex, Schaffner, Francis, Della Torre, Alessandra, Miranda, Miguel Ángel, Koopmans, Marion, Barzon, Luisa, and Bartumeus Ferre, Frederic

Abstract

The Mosquito Alert dataset includes occurrence records of adult mosquitoes collected worldwide in 2014-2020 through Mosquito Alert, a citizen science system for investigating and managing disease-carrying mosquitoes. Records are linked to citizen science-submitted photographs and validated by entomologists to determine the presence of five targeted European mosquito vectors: Aedes albopictus, Ae. aegypti, Ae. japonicus, Ae. koreicus, and Culex pipiens. Most records are from Spain, reflecting Spanish national and regional funding, but since autumn 2020 substantial records from other European countries are included, thanks to volunteer entomologists coordinated by the AIM-COST Action, and to technological developments to increase scalability. Among other applications, the Mosquito Alert dataset will help develop citizen science-based early warning systems for mosquito-borne disease risk. It can also be reused for modelling vector exposure risk, or to train machine-learning detection and classification routines on the linked images, to assist with data validation and establishing automated alert systems.

Published
2022

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