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According to statistical data given in the article the incidence of oropharyngeal cancer increases, despite the ease of access to the maxillofacial area and the possibility to make visual and manual examination of this site. It should be stressed that locally advanced oropharyngeal cancer of the III-IV stages was the first diagnosis in 82.9% of patients. It may be due to low level suspicion of primary care physicians. The paper considers risk factors for development of oropharyngeal cancer and presents the list of compulsory diagnostic tests. The authors suggest that recommended diagnostic algorithm will be helpful to a timely detection of precancer and cancer abnormalities in the oropharynx in order to minimize the time and to define the optimal scheduling of examination of a patient in specialized health care centers for early detection of cancer.

Diabetic retinopathy (DR) is an important, socially significant complication of diabetes mellitus that leads to irreversible loss of vision. This article reviews the studies of peripheral changes in DR, different methods used in its diagnostics, monitoring and assessment of therapeutic effects. The article contains detailed examination of the modern widefield imaging methods that allow studying the middle and extreme periphery of the retina and help obtain a wide range of DR biomarkers. Of greatest interest in this matter is optical coherence tomography angiography due to possibility of detailed non-invasive assessment of the condition of retinal microvasculature, precise determination of the area and visualization of the sites of neovascularization and non-perfused regions of the retina. Quantitative characteristics of these changes serve as important diagnostic and prognostic visual biomarkers of DR.

The review addresses the current state of atomic force microscopy (AFM) usage in ophthalmology. Briefly presented here are the history of the development of AFM, principles and modes of operation, its advantages, disadvantages, as well as a comparison with other types of microscopy. The review describes the capabilities of AFM in visualization of various structures of the eye. A significant part of the review is devoted to the study of the retina, which arouses great interest among researchers. In particular, the possibilities of AFM for visualization at the submicron level of various structures in the retina, such as the internal limiting membrane, membrane cells, Müller cells, retinal pigment epithelium in their normal state and in the presence of a pathology (age-related macular degeneration, diabetes mellitus) were reviewed. In addition, several study papers were analyzed, providing a base for the judgement of the mechanical properties of said structures. An AFM study of the visual pigment rhodopsin helped identify its dimeric structure. The stability of the rhodopsin molecule was proved to be determined by the degree of strength of its individual segments connected to each other. The AFM method is a highly accurate method that helps solve many fundamental and practical problems, particularly in ophthalmology.