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5. Somatostatin Receptor Imaging with [18F]FET-bAG-TOCA PET/CT and [68Ga]Ga-DOTA-Peptide PET/CT in Patients with Neuroendocrine Tumors: A Prospective, Phase 2 Comparative Study.

Author

Dubash, Suraiya, Barwick, Tara D., Kozlowski, Kasia, Rockall, Andrea G., Khan, Sairah, Khan, Sameer, Yusuf, Siraj, Lamarca, Angela, Valle, Juan W., Hubner, Richard A., McNamara, Mairéad G., Frilling, Andrea, Tan, Tricia, Wernig, Florian, Todd, Jeannie, Meeran, Karim, Pratap, Bhavesh, Azeem, Saleem, Huiban, Michael, and Keat, Nicholas

Published
2024
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7. Somatostatin Receptor Imaging with [18F]FET-βAG-TOCA PET/CT and [68Ga]Ga-DOTA-Peptide PET/CT in Patients with Neuroendocrine Tumors: A Prospective, Phase 2 Comparative Study

Author

Dubash, Suraiya, primary, Barwick, Tara D., additional, Kozlowski, Kasia, additional, Rockall, Andrea G., additional, Khan, Sairah, additional, Khan, Sameer, additional, Yusuf, Siraj, additional, Lamarca, Angela, additional, Valle, Juan W., additional, Hubner, Richard A., additional, McNamara, Mairéad G., additional, Frilling, Andrea, additional, Tan, Tricia, additional, Wernig, Florian, additional, Todd, Jeannie, additional, Meeran, Karim, additional, Pratap, Bhavesh, additional, Azeem, Saleem, additional, Huiban, Michael, additional, Keat, Nicholas, additional, Lozano-Kuehne, Jingky P., additional, Aboagye, Eric O., additional, and Sharma, Rohini, additional

Published
2024
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10. Bench to Bedside Development of [18F]Fluoromethyl-(1,2-2H4)choline ([18F]D4-FCH)

Author

Challapalli, Amarnath, primary, Barwick, Tara D., additional, Dubash, Suraiya R., additional, Inglese, Marianna, additional, Grech-Sollars, Matthew, additional, Kozlowski, Kasia, additional, Tam, Henry, additional, Patel, Neva H., additional, Winkler, Mathias, additional, Flohr, Penny, additional, Saleem, Azeem, additional, Bahl, Amit, additional, Falconer, Alison, additional, De Bono, Johann S., additional, Aboagye, Eric O., additional, and Mangar, Stephen, additional

Published
2023
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15. Neuroendocrine tumours

Author

Khan, Sairah R, primary, Wallitt, Kathryn L, additional, Al-Nahhas, Adil, additional, and Barwick, Tara D, additional

Published
2020
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16. Discovery of pre-therapy 2-deoxy-2-18F-fluoro-D-glucose positron emission tomography-based radiomics classifiers of survival outcome in non-small-cell lung cancer patients

Author

Arshad, Mubarik A., Thornton, Andrew, Lu, Haonan, Tam, Henry, Wallitt, Kathryn, Rodgers, Nicola, Scarsbrook, Andrew, McDermott, Garry, Cook, Gary J., Landau, David, Chua, Sue, O’Connor, Richard, Dickson, Jeanette, Power, Danielle A., Barwick, Tara D., Rockall, Andrea, and Aboagye, Eric O.

Published
2019
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17. Effect of blood glucose level on standardized uptake value (SUV) in 18F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements

Author

Eskian, Mahsa, Alavi, Abass, Khorasanizadeh, MirHojjat, Viglianti, Benjamin L., Jacobsson, Hans, Barwick, Tara D., Meysamie, Alipasha, Yi, Sun K., Iwano, Shingo, Bybel, Bohdan, Caobelli, Federico, Lococo, Filippo, Gea, Joaquim, Sancho-Muñoz, Antonio, Schildt, Jukka, Tatcı, Ebru, Lapa, Constantin, Keramida, Georgia, Peters, Michael, Boktor, Raef R., John, Joemon, Pitman, Alexander G., Mazurek, Tomasz, and Rezaei, Nima

Published
2019
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18. A Subset of Non-Small Cell Lung Cancer Patients Treated with Pemetrexed Show 18F-Fluorothymidine “Flare” on Positron Emission Tomography

Author

Aravind, Preetha, primary, Popat, Sanjay, additional, Barwick, Tara D., additional, Soneji, Neil, additional, Lythgoe, Mark, additional, Sreter, Katherina B., additional, Lozano-Kuehne, Jingky P., additional, Bergqvist, Mattias, additional, Patel, Neva, additional, Aboagye, Eric O., additional, and Kenny, Laura M., additional

Published
2023
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19. Development and Evaluation of Machine Learning in Whole-Body Magnetic Resonance Imaging for Detecting Metastases in Patients With Lung or Colon Cancer

Author

Rockall, Andrea G., primary, Li, Xingfeng, additional, Johnson, Nicholas, additional, Lavdas, Ioannis, additional, Santhakumaran, Shalini, additional, Prevost, A. Toby, additional, Punwani, Shonit, additional, Goh, Vicky, additional, Barwick, Tara D., additional, Bharwani, Nishat, additional, Sandhu, Amandeep, additional, Sidhu, Harbir, additional, Plumb, Andrew, additional, Burn, James, additional, Fagan, Aisling, additional, Wengert, Georg J., additional, Koh, Dow-Mu, additional, Reczko, Krystyna, additional, Dou, Qi, additional, Warwick, Jane, additional, Liu, Xinxue, additional, Messiou, Christina, additional, Tunariu, Nina, additional, Boavida, Peter, additional, Soneji, Neil, additional, Johnston, Edward W., additional, Kelly-Morland, Christian, additional, De Paepe, Katja N., additional, Sokhi, Heminder, additional, Wallitt, Kathryn, additional, Lakhani, Amish, additional, Russell, James, additional, Salib, Miriam, additional, Vinnicombe, Sarah, additional, Haq, Adam, additional, Aboagye, Eric O., additional, Taylor, Stuart, additional, and Glocker, Ben, additional

Published
2023
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20. Bench to Bedside Development of [ 18 F]Fluoromethyl-(1,2- 2 H 4)choline ([ 18 F]D4-FCH).

Author

Challapalli, Amarnath, Barwick, Tara D., Dubash, Suraiya R., Inglese, Marianna, Grech-Sollars, Matthew, Kozlowski, Kasia, Tam, Henry, Patel, Neva H., Winkler, Mathias, Flohr, Penny, Saleem, Azeem, Bahl, Amit, Falconer, Alison, De Bono, Johann S., Aboagye, Eric O., and Mangar, Stephen

Subjects
*RADIOACTIVE tracers, *CHOLINE, *POSITRON emission tomography, *RADIATION dosimetry, *PROSTATE cancer patients, *FLUOROPOLYMERS, *AMINO acid oxidase
Abstract

Malignant transformation is characterised by aberrant phospholipid metabolism of cancers, associated with the upregulation of choline kinase alpha (CHKα). Due to the metabolic instability of choline radiotracers and the increasing use of late-imaging protocols, we developed a more stable choline radiotracer, [18F]fluoromethyl-[1,2-2H4]choline ([18F]D4-FCH). [18F]D4-FCH has improved protection against choline oxidase, the key choline catabolic enzyme, via a 1H/2D isotope effect, together with fluorine substitution. Due to the promising mechanistic and safety profiles of [18F]D4-FCH in vitro and preclinically, the radiotracer has transitioned to clinical development. [18F]D4-FCH is a safe positron emission tomography (PET) tracer, with a favourable radiation dosimetry profile for clinical imaging. [18F]D4-FCH PET/CT in lung and prostate cancers has shown highly heterogeneous intratumoral distribution and large lesion variability. Treatment with abiraterone or enzalutamide in metastatic castrate-resistant prostate cancer patients elicited mixed responses on PET at 12–16 weeks despite predominantly stable radiological appearances. The sum of the weighted tumour-to-background ratios (TBRs-wsum) was associated with the duration of survival. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Feasibility of [18F]fluoropivalate hybrid PET/MRI for imaging lower and higher grade glioma: a prospective first-in-patient pilot study.

Author

Islam, Shahriar, Inglese, Marianna, Grech-Sollars, Matthew, Aravind, Preetha, Dubash, Suraiya, Barwick, Tara D., O'Neill, Kevin, Wang, James, Saleem, Azeem, O'Callaghan, James, Anchini, Giulio, Williams, Matthew, Waldman, Adam, and Aboagye, Eric O.

Subjects
MAGNETIC resonance imaging, CONTRAST-enhanced magnetic resonance imaging, SHORT-chain fatty acids, GLIOMAS, BRAIN tumors, STEREOTACTIC radiosurgery
Abstract

Purpose: MRI and PET are used in neuro-oncology for the detection and characterisation of lesions for malignancy to target surgical biopsy and to plan surgical resections or stereotactic radiosurgery. The critical role of short-chain fatty acids (SCFAs) in brain tumour biology has come to the forefront. The non-metabolised SCFA radiotracer, [18F]fluoropivalate (FPIA), shows low background signal in most tissues except eliminating organs and has appropriate human dosimetry. Tumour uptake of the radiotracer is, however, unknown. We investigated the uptake characteristics of FPIA in this pilot PET/MRI study. Methods: Ten adult glioma subjects were identified based on radiological features using standard-of-care MRI prior to any surgical intervention, with subsequent histopathological confirmation of glioma subtype and grade (lower-grade – LGG – and higher-grade – HGG – patients). FPIA was injected as an intravenous bolus injection (range 342–368 MBq), and dynamic PET and MRI data were acquired simultaneously over 66 min. Results: All patients tolerated the PET/MRI protocol. Three patients were reclassified following resection and histology. Tumour maximum standardised uptake value (SUVmax,60) increased in the order LGG (WHO grade 2) < HGG (WHO grade 3) < HGG (WHO grade 4). The net irreversible solute transfer, Ki, and influx rate constant, K1, were significantly higher in HGG (p < 0.05). Of the MRI variables studied, DCE-MRI-derived extravascular-and-extracellular volume fraction (ve) was high in tumours of WHO grade 4 compared with other grades (p < 0.05). SLC25A20 protein expression was higher in HGG compared with LGG. Conclusion: Tumoural FPIA PET uptake is higher in HGG compared to LGG. This study supports further investigation of FPIA PET/MRI for brain tumour imaging in a larger patient population. Clinical trial registration: Clinicaltrials.gov, NCT04097535. [ABSTRACT FROM AUTHOR]

Published
2023
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28. A Subset of Non-Small Cell Lung Cancer Patients Treated with Pemetrexed Show 18 F-Fluorothymidine "Flare" on Positron Emission Tomography.

Author

Aravind, Preetha, Popat, Sanjay, Barwick, Tara D., Soneji, Neil, Lythgoe, Mark, Sreter, Katherina B., Lozano-Kuehne, Jingky P., Bergqvist, Mattias, Patel, Neva, Aboagye, Eric O., and Kenny, Laura M.

Subjects
LUNG cancer, CANCER chemotherapy, POSITRON emission tomography computed tomography, METASTASIS, TREATMENT effectiveness, CANCER patients, RADIOPHARMACEUTICALS, RESEARCH funding, DESCRIPTIVE statistics, PEMETREXED, OVERALL survival
Abstract

Simple Summary: Thymidylate synthase (TS) inhibitors have remained among the most effective chemotherapies used in the treatment of various cancer types. Imaging of tumour proliferative activity while on antifolates has been studied with 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography (18F-FLT PET) imaging. The aim of this study was to use 18F-FLT PET/CT imaging to understand the basis of early drug action with the antifolate drug pemetrexed on TS inhibition. While every patient showed a global change in the plasma marker of TS inhibition after drug administration, tumour TS inhibition was selective and patients who showed a tumour change in the imaging biomarker had a greater therapy response and longer overall survival following a combination treatment including pemetrexed. The study findings implicate the potential use of 18F-FLT PET/CT to understand the basis of drug action in other studies involving TS inhibitors. Thymidylate synthase (TS) remains a major target for cancer therapy. TS inhibition elicits increases in DNA salvage pathway activity, detected as a transient compensatory "flare" in 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography (18F-FLT PET). We determined the magnitude of the 18F-FLT flare in non-small cell lung cancer (NSCLC) patients treated with the antifolate pemetrexed in relation to clinical outcome. Method: Twenty-one patients with advanced/metastatic non-small cell lung cancer (NSCLC) scheduled to receive palliative pemetrexed ± platinum-based chemotherapy underwent 18F-FLT PET at baseline and 4 h after initiating single-agent pemetrexed. Plasma deoxyuridine (dUrd) levels and thymidine kinase 1 (TK1) activity were measured before each scan. Patients were then treated with the combination therapy. The 18F-FLT PET variables were compared to RECIST 1.1 and overall survival (OS). Results: Nineteen patients had evaluable PET scans at both time points. A total of 32% (6/19) of patients showed 18F-FLT flares (>20% change in SUVmax-wsum). At the lesion level, only one patient had an FLT flare in all the lesions above (test–retest borders). The remaining had varied uptake. An 18F-FLT flare occurred in all lesions in 1 patient, while another patient had an 18F-FLT reduction in all lesions; 17 patients showed varied lesion uptake. All patients showed global TS inhibition reflected in plasma dUrd levels (p < 0.001) and 18F-FLT flares of TS-responsive normal tissues including small bowel and bone marrow (p = 0.004 each). Notably, 83% (5/6) of patients who exhibited 18F-FLT flares were also RECIST responders with a median OS of 31 m, unlike patients who did not exhibit 18F-FLT flares (15 m). Baseline plasma TK1 was prognostic of survival but its activity remained unchanged following treatment. Conclusions: The better radiological response and longer survival observed in patients with an 18F-FLT flare suggest the efficacy of the tracer as an indicator of the early therapeutic response to pemetrexed in NSCLC. [ABSTRACT FROM AUTHOR]

Published
2023
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29. [18F]Fluorothymidine(FLT)-PET imaging of thymidine kinase 1 pharmacodynamics in non-small cell lung cancer treated with pemetrexed.

Author

Aravind, Preetha, primary, Popat, Sanjay, additional, Barwick, Tara D., additional, Soneji, Neil, additional, Lythgoe, Mark, additional, Lozano-kuehne, Jingky, additional, Sreter, Katherina Bernadette, additional, Bergqvist, Mattias, additional, Patel, Neva H., additional, Aboagye, Eric O., additional, and Kenny, Laura M., additional

Published
2022
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33. Diagnostic Accuracy of FEC-PET/CT, FDG-PET/CT, and Diffusion-Weighted MRI in Detection of Nodal Metastases in Surgically Treated Endometrial and Cervical Carcinoma

Author

Rockall, Andrea G., primary, Barwick, Tara D., additional, Wilson, William, additional, Singh, Naveena, additional, Bharwani, Nishat, additional, Sohaib, Aslam, additional, Nobbenhuis, Marielle, additional, Warbey, Victoria, additional, Miquel, Marc, additional, Koh, Dow-Mu, additional, De Paepe, Katja N., additional, Martin-Hirsch, Pierre, additional, Ghaem-Maghami, Sadaf, additional, Fotopoulou, Christina, additional, Stringfellow, Helen, additional, Sundar, Sudha, additional, Manchanda, Ranjit, additional, Sahdev, Anju, additional, Hackshaw, Allan, additional, and Cook, Gary J., additional

Published
2021
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34. Abstract PD6-09: Herpet study- PET imaging of HER2 expression in breast cancer using the novel Affibody tracer [18F]GE-226, a first in patient study

Author

Kenny, Laura M., primary, Gopalakrishnan, Gosala S., additional, Barwick, Tara D., additional, Vaja, Vijay, additional, McDevitt, S. Hope, additional, Punjani, Robert, additional, Patel, Neva H., additional, Ramakrishnan, Rathi, additional, Patel, Naina R., additional, Johnston, Stephen, additional, Mansi, Janine, additional, Cook, Gary J., additional, Gilbert, Fiona J., additional, Aigbirhio, Franklin I., additional, Hiscock, Duncan, additional, and Aboagye, Eric O., additional

Published
2021
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37. Optimal method for metabolic tumour volume assessment of cervical cancers with inter-observer agreement on [18F]-fluoro-deoxy-glucose positron emission tomography with computed tomography

Author

Arshad, Mubarik A., primary, Gitau, Samuel, additional, Tam, Henry, additional, Park, Won-Ho E., additional, Patel, Neva H., additional, Rockall, Andrea, additional, Aboagye, Eric O., additional, Bharwani, Nishat, additional, and Barwick, Tara D., additional

Published
2020
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44. Monitoring Response to Transarterial Chemoembolization in Hepatocellular Carcinoma Using 18F-Fluorothymidine PET

Author

Sharma, Rohini, primary, Inglese, Marianna, additional, Dubash, Suraiya, additional, Lu, Haonan, additional, Pinato, David J., additional, Sanghera, Chandan, additional, Patel, Neva, additional, Chung, Anthony, additional, Tait, Paul D., additional, Mauri, Francesco, additional, Crum, William R., additional, Barwick, Tara D., additional, and Aboagye, Eric O., additional

Published
2020
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46. Clinical translation of 18F-fluoropivalate – a PET tracer for imaging short-chain fatty acid metabolism: safety, biodistribution, and dosimetry in fed and fasted healthy volunteers

Author

Dubash, Suraiya R., primary, Keat, Nicholas, additional, Kozlowski, Kasia, additional, Barnes, Chris, additional, Allott, Louis, additional, Brickute, Diana, additional, Hill, Sam, additional, Huiban, Mickael, additional, Barwick, Tara D., additional, Kenny, Laura, additional, and Aboagye, Eric O., additional

Published
2020
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47. Imaging and Tissue Biomarkers of Choline Metabolism in Diffuse Adult Glioma: 18F-Fluoromethylcholine PET/CT, Magnetic Resonance Spectroscopy, and Choline Kinase α

Author

Grech-Sollars, Matthew, primary, Ordidge, Katherine L, additional, Vaqas, Babar, additional, Davies, Claire, additional, Vaja, Vijay, additional, Honeyfield, Lesley, additional, Camp, Sophie, additional, Towey, David, additional, Mayers, Helen, additional, Peterson, David, additional, O’Neill, Kevin, additional, Roncaroli, Federico, additional, Barwick, Tara D, additional, and Waldman, Adam D, additional

Published
2019
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48. [18F]Fluciclatide PET as a biomarker of response to combination therapy of pazopanib and paclitaxel in platinum-resistant/refractory ovarian cancer

Author

Sharma, Rohini, primary, Valls, Pablo Oriol, additional, Inglese, Marianna, additional, Dubash, Suraiya, additional, Chen, Michelle, additional, Gabra, Hani, additional, Montes, Ana, additional, Challapalli, Amarnath, additional, Arshad, Mubarik, additional, Tharakan, George, additional, Chambers, Ed, additional, Cole, Tom, additional, Lozano-Kuehne, Jingky P., additional, Barwick, Tara D., additional, and Aboagye, Eric O., additional

Published
2019
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49. Effect of blood glucose level on standardized uptake value (SUV) in F-18- FDG PET-scan : a systematic review and meta-analysis of 20,807 individual SUV measurements

Author

Eskian, Mahsa, Alavi, Abass, Khorasanizadeh, MirHojjat, Viglianti, Benjamin L., Jacobsson, Hans, Barwick, Tara D., Meysamie, Alipasha, Yi, Sun K., Iwano, Shingo, Bybel, Bohdan, Caobelli, Federico, Lococo, Filippo, Gea, Joaquim, Sancho-Munoz, Antonio, Schildt, Jukka, Tatci, Ebru, Lapa, Constantin, Keramida, Georgia, Peters, Michael, Boktor, Raef R., John, Joemon, Pitman, Alexander G., Mazurek, Tomasz, Rezaei, Nima, Department of Diagnostics and Therapeutics, Clinicum, and HUS Medical Imaging Center

Subjects
EXPRESSION, TRANSPORTER, PET scan, Blood glucose level, METABOLISM, 3126 Surgery, anesthesiology, intensive care, radiology, INSULIN, SUV, DIABETIC-PATIENTS, 18F-FDG, Diabetes mellitus, POSITRON-EMISSION-TOMOGRAPHY, LUNG-CANCER, HYPERGLYCEMIA, PET quantification, BRAIN-BARRIER, SQUAMOUS-CELL CARCINOMA
Abstract

Objectives To evaluate the effect of pre-scan blood glucose levels (BGL) on standardized uptake value (SUV) in F-18-FDG-PET scan. Methods A literature review was performed in the MEDLINE, Embase, and Cochrane library databases. Multivariate regression analysis was performed on individual datum to investigate the correlation of BGL with SUVmax and SUVmean adjusting for sex, age, body mass index (BMI), diabetes mellitus diagnosis, F-18-FDG injected dose, and time interval. The ANOVA test was done to evaluate differences in SUVmax or SUVmean among five different BGL groups (200 mg/dl). Results Individual data for a total of 20,807 SUVmax and SUVmean measurements from 29 studies with 8380 patients was included in the analysis. Increased BGL is significantly correlated with decreased SUVmax and SUVmean in brain (p

Published
2019

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