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135 results on '"Barutcu, Ahmet"'

1. Fully Automated Myocardial Strain Estimation from CMR Tagged Images using a Deep Learning Framework in the UK Biobank

Author

Ferdian, Edward, Suinesiaputra, Avan, Fung, Kenneth, Aung, Nay, Lukaschuk, Elena, Barutcu, Ahmet, Maclean, Edd, Paiva, Jose, Piechnik, Stefan K., Neubauer, Stefan, Petersen, Steffen E, and Young, Alistair A.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Physics - Medical Physics
Abstract

Purpose: To demonstrate the feasibility and performance of a fully automated deep learning framework to estimate myocardial strain from short-axis cardiac magnetic resonance tagged images. Methods and Materials: In this retrospective cross-sectional study, 4508 cases from the UK Biobank were split randomly into 3244 training and 812 validation cases, and 452 test cases. Ground truth myocardial landmarks were defined and tracked by manual initialization and correction of deformable image registration using previously validated software with five readers. The fully automatic framework consisted of 1) a convolutional neural network (CNN) for localization, and 2) a combination of a recurrent neural network (RNN) and a CNN to detect and track the myocardial landmarks through the image sequence for each slice. Radial and circumferential strain were then calculated from the motion of the landmarks and averaged on a slice basis. Results: Within the test set, myocardial end-systolic circumferential Green strain errors were -0.001 +/- 0.025, -0.001 +/- 0.021, and 0.004 +/- 0.035 in basal, mid, and apical slices respectively (mean +/- std. dev. of differences between predicted and manual strain). The framework reproduced significant reductions in circumferential strain in diabetics, hypertensives, and participants with previous heart attack. Typical processing time was ~260 frames (~13 slices) per second on an NVIDIA Tesla K40 with 12GB RAM, compared with 6-8 minutes per slice for the manual analysis. Conclusions: The fully automated RNNCNN framework for analysis of myocardial strain enabled unbiased strain evaluation in a high-throughput workflow, with similar ability to distinguish impairment due to diabetes, hypertension, and previous heart attack., Comment: accepted in Radiology Cardiothoracic Imaging

Published
2020
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4. Toward Replacing Late Gadolinium Enhancement With Artificial Intelligence Virtual Native Enhancement for Gadolinium-Free Cardiovascular Magnetic Resonance Tissue Characterization in Hypertrophic Cardiomyopathy

Author

Zhang, Qiang, Burrage, Matthew K., Lukaschuk, Elena, Shanmuganathan, Mayooran, Popescu, Iulia A., Nikolaidou, Chrysovalantou, Mills, Rebecca, Werys, Konrad, Hann, Evan, Barutcu, Ahmet, Polat, Suleyman D., Salerno, Michael, Jerosch-Herold, Michael, Kwong, Raymond Y., Watkins, Hugh C., Kramer, Christopher M., Neubauer, Stefan, Ferreira, Vanessa M., and Piechnik, Stefan K.

Published
2021
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5. Changes in Cardiac Morphology and Function in Individuals With Diabetes Mellitus: The UK Biobank Cardiovascular Magnetic Resonance Substudy

Author

Jensen, Magnus T., Fung, Kenneth, Aung, Nay, Sanghvi, Mihir M., Chadalavada, Sucharitha, Paiva, Jose M., Khanji, Mohammed Y., de Knegt, Martina C., Lukaschuk, Elena, Lee, Aaron M., Barutcu, Ahmet, Maclean, Edd, Carapella, Valentina, Cooper, Jackie, Young, Alistair, Piechnik, Stefan K., Neubauer, Stefan, and Petersen, Steffen E.

Published
2019
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6. The association between cardiac mr feature tracking strain and myocardial late gadolinium enhancement in patients with hypertrophic cardiomyopathy

Author

Ozden, Ozge, primary, Unlu, Serkan, additional, Kilic, Dogu Ismail, additional, Sherif, Sara Abu, additional, Opan, Selcuk, additional, Kemal, Hatice S., additional, Ozmen, Emre, additional, Tuner, Hasim, additional, Bingol, Gulsum, additional, Barutcu, Ahmet, additional, Nasifov, Muharrem, additional, Bakan, Selim, additional, and Goktekin, Omer, additional

Published
2023
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15. Okul yöneticilerinin sergiledikleri takım liderliği davranışları ile öğretmen motivasyonları arasındaki ilişki

Author

Barutcu, Ahmet

Subjects
Takım liderliği, Öğretmen, Okul yöneticisi, Motivasyon
Abstract

Bu çalışmanın amacı, ilkokul ve ortaokul öğretmenlerinin algılarına göre okul yöneticilerinin takım liderliği davranışları ile öğretmenlerin motivasyonları arasındaki ilişkiyi incelemektir. Tarama modelinde yürütülen bu araştırmanın örneklemi, Denizli İli Çivril ilçesindeki ilköğretim ve ortaöğretim okullarında görev yapan 217 öğretmenden oluşmaktadır. Araştırma için gerekli verileri,“Takım Liderliği Ölçeği” ve “Öğretmen Motivasyon Ölçeği” aracılığıyla toplanmıştır. Araştırmada elde edilen verilerin analizinde öncelikle öğretmenlerin yöneticilerinin takım liderliği davranışlarını ve motivasyon düzeylerini belirlemeye yönelik betimsel istatistik değerleri(aritmetik ortalama, standart sapma) hesaplanmış, demografik değişkenlerine ilişkin karşılaştırmalarda da t-testi ve tek yönlü varyans analizi kullanılmıştır. Ayrıca takım liderliği davranışları ile motivasyon düzeyleri arasındaki ilişkiyi belirlemek için Pearson Çarpım Moment Korelasyon analizinden yararlanılmıştır. Araştırmada elde edilen bulgular doğrultusunda öğretmenlerin yöneticilerinin takım liderliği davranışlarını sergilediklerini düşündükleri ve motivasyon düzeylerinin de yüksek olduğu sonucuna ulaşılmıştır. Bunun yanı sıra, okul yöneticilerinin takım liderliği davranışlarını sergilemeleri ile öğretmenlerin motivasyon düzeyleri arasında bir ilişkinin olduğu sonucuna ulaşılmıştır.

Published
2020

19. Association Between Recreational Cannabis Use and Cardiac Structure and Function

Author

Khanji, Mohammed Y., primary, Jensen, Magnus T., additional, Kenawy, Asmaa A., additional, Raisi-Estabragh, Zahra, additional, Paiva, Jose M., additional, Aung, Nay, additional, Fung, Kenneth, additional, Lukaschuk, Elena, additional, Zemrak, Filip, additional, Lee, Aaron M., additional, Barutcu, Ahmet, additional, Maclean, Edd, additional, Cooper, Jackie, additional, Piechnik, Stefan K., additional, Neubauer, Stefan, additional, and Petersen, Steffen E., additional

Published
2020
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20. Fully Automated Myocardial Strain Estimation from Cardiovascular MRI–tagged Images Using a Deep Learning Framework in the UK Biobank

Author

Ferdian, Edward, primary, Suinesiaputra, Avan, additional, Fung, Kenneth, additional, Aung, Nay, additional, Lukaschuk, Elena, additional, Barutcu, Ahmet, additional, Maclean, Edd, additional, Paiva, Jose, additional, Piechnik, Stefan K., additional, Neubauer, Stefan, additional, Petersen, Steffen E., additional, and Young, Alistair A., additional

Published
2020
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21. Total Mapping Toolbox (TOMATO): An open source library for cardiac magnetic resonance parametric mapping

Author

Werys, Konrad, primary, Dragonu, Iulius, additional, Zhang, Qiang, additional, Popescu, Iulia, additional, Hann, Evan, additional, Puchta, Henrike, additional, Kubik, Agata, additional, Polat, Dogan, additional, Wu, Cody, additional, Moon, Niall O., additional, Barutcu, Ahmet, additional, Ferreira, Vanessa M., additional, and Piechnik, Stefan K., additional

Published
2020
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23. Right ventricular function and its relationship with grade of hepatosteatosis in non-alcoholic fatty liver disease

Author

Bekler, Adem, Gazi, Emıne, Erbag, Gokhan, Binnetoglu, Emine, Barutcu, Ahmet, Sen, Hacer, Temiz, Ahmet, and Altun, Burak

Subjects
Adult, Echocardiography, Doppler, Pulsed, Male, Systole, Cardiovascular Topics, Ventricular Dysfunction, Right, Middle Aged, Severity of Illness Index, hepatosteatosis, Diastole, Non-alcoholic Fatty Liver Disease, Predictive Value of Tests, Risk Factors, Case-Control Studies, Ventricular Function, Right, echocardiography, right ventricular dysfunction, Humans, Female
Abstract

Summary Objective This study was designed to assess right ventricular systolic and diastolic function and its relationship with grade of hepatosteatosis (HS) in non-alcoholic fatty liver disease (NAFLD) patients using conventional and tissue Doppler echocardiography. Methods NAFLD was diagnosed in 32 individuals (15 males, 17 females; 59% were grade I HS, 41% grade II–III HS) by means of ultrasonography. Twenty-two individuals, whose ultrasonography data did not show HS, comprised the control group (11 males, 11 females) and were included in the study. Right ventricular systolic and diastolic function and their relationship with grade of HS were assessed by conventional and tissue Doppler echocardiography. Additionally, right ventricular global function was assessed by myocardial performance index (MPI). Results When compared by conventional echocardiographic parameters, there were no significant differences between the two groups. With tissue Doppler parameters, the tricuspid annulus peak early diastolic velocity and ratio of early-tolate diastolic velocity were lower in the patients than in the controls (p = 0.03, p = 0.02, respectively). The isovolumetric relaxation time and MPI were significantly higher (p < 0.001, p < 0.001, respectively) in the patient group. HS grade was positively correlated with right ventricular isovolumetric relaxation time and MPI index (r = 0.295, p = 0.03, r = 0.641, p < 0.001, respectively). Conclusion These results show that right ventricular diastolic dysfunction (RVDD) in patients with NAFLD and degree of HS was associated with RVDD.

Published
2015

25. Intranuclear and higher‐order chromatin organization of the major histone gene cluster in breast cancer

Author

Fritz, Andrew J., primary, Ghule, Prachi N., additional, Boyd, Joseph R., additional, Tye, Coralee E., additional, Page, Natalie A., additional, Hong, Deli, additional, Shirley, David J., additional, Weinheimer, Adam S., additional, Barutcu, Ahmet R., additional, Gerrard, Diana L., additional, Frietze, Seth, additional, van Wijnen, Andre J., additional, Zaidi, Sayyed K., additional, Imbalzano, Anthony N., additional, Lian, Jane B., additional, Stein, Janet L., additional, and Stein, Gary S., additional

Published
2017
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27. Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.

Author

Fritz, Andrew J., Ghule, Prachi N., Boyd, Joseph R., Tye, Coralee E., Page, Natalie A., Hong, Deli, Shirley, David J., Weinheimer, Adam S., Barutcu, Ahmet R., Gerrard, Diana L., Frietze, Seth, van Wijnen, Andre J., Zaidi, Sayyed K., Imbalzano, Anthony N., Lian, Jane B., Stein, Janet L., and Stein, Gary S.

Subjects
GENETICS of breast cancer, CHROMATIN, HISTONES, CANCER invasiveness, CELL morphology, GENE expression
Abstract

Alterations in nuclear morphology are common in cancer progression. However, the degree to which gross morphological abnormalities translate into compromised higherorder chromatin organization is poorly understood. To explore the functional links between gene expression and chromatin structure in breast cancer, we performed RNAseq gene expression analysis on the basal breast cancer progression model based on human MCF10A cells. Positional gene enrichment identified the major histone gene cluster at chromosome 6p22 as one of the most significantly upregulated (and not amplified) clusters of genes from the normal-like MCF10A to premalignant MCF10AT1 and metastatic MCF10CA1a cells. This cluster is subdivided into three sub-clusters of histone genes that are organized into hierarchical topologically associating domains (TADs). Interestingly, the sub-clusters of histone genes are located atTADboundaries and interact more frequently with each other than the regions in-between them, suggesting that the histone sub-clusters form an active chromatin hub. The anchor sites of loops within this hub are occupied by CTCF, a known chromatin organizer. These histone genes are transcribed and processed at a specific sub-nuclear microenvironment termed the major histone locus body (HLB).While the overall chromatin structure of the major HLB is maintained across breast cancer progression, we detected alterations in its structure that may relate to gene expression. Importantly, breast tumor specimens also exhibit a coordinate pattern of upregulation across the major histone gene cluster. Our results provide a novel insight into the connection between the higher-order chromatin organization of the major HLB and its regulation during breast cancer progression. [ABSTRACT FROM AUTHOR]

Published
2018
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28. Comparison of the GRACE risk score and the TIMI risk index in predicting the extent and severity of coronary artery disease in patients with acute coronary syndrome

Author

Bekler, Adem, primary, Altun, Burak, additional, Gazi, Emine, additional, Temiz, Ahmet, additional, Barutcu, Ahmet, additional, Gungor, Omer, additional, Ozkan, Muhammed Turgut Alper, additional, Ozcan, Sedat, additional, Gazi, Sabri, additional, and Kirilmaz, Bahadir, additional

Published
2015
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40. Epicardial Adipose Tissue Thickness in Hemodialysis Patients

Author

Altun, Burak, primary, Tasolar, Hakan, additional, Eren, Necmi, additional, Binnetoğlu, Emine, additional, Altun, Mehzat, additional, Temiz, Ahmet, additional, Gazi, Emine, additional, Barutcu, Ahmet, additional, Altunoren, Orcun, additional, Colkesen, Yucel, additional, and Uysal, Fatma, additional

Published
2013
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48. Fragmented QRS and prediction of paroxysmal atrial fibrillation episodes.

Author

Temiz, Ahmet, Gazi, Emine, Güngör, Ömer, Altun, Burak, Barutcu, Ahmet, Bekler, Adem, Tan, Yusuf Ziya, Ozcan, Sedat, Yener, Ali Ümit, and Kurt, Tolga

Subjects
ATRIAL fibrillation, CARDIOVASCULAR disease diagnosis, VENTRICULAR arrhythmia, PATIENT monitoring, LOGISTIC regression analysis, CONFIDENCE intervals, PATIENTS, DIAGNOSIS
Abstract

Objective: Prior studies have demonstrated the relationship between cardiovascular diseases and fragmented QRS (fQRS). fQRS was also associated with ventricular arrhythmias. Our objective was to find out the relationship between fQRS and paroxysmal atrial fibrillation (PAF). Method: A total of 301 patients without overt structural heart disease were prospectively included in the study. Patients were divided in to 2 groups according to presence of fQRS. Multivariate logistic regression analysis was used to assess the predictive value of fQRS for predicting PAF. Results: One hundred and three patients had fQRS. Patients with fQRS were older (53±16.8 vs 45.3±17.2, p < 0.001), with larger left atrium (LA) (33.2±5.9 vs 30.1±5.9 mm, p=0.001), with thicker interventricular septum (IVS) (10.2±1.9 vs 9.5±2.3 mm, p=0.032), more diabetic (19.8 vs 10.6%, p=0.029) and have more PAF episodes (22.3 vs 4.1%, p < 0.001) in comparison with patients without fQRS. fQRS was an independent predictor of detecting PAF episode (odds ratio, 9.69; 95% confidence interval, 2.46-38.15, p=0.001). Hypertension and diabetes mellitus were also predictive. Conclusion: The presence of fQRS independently predicted PAF episodes in holter monitoring (HM). Further studies are needed to clarify the clinical implications of this finding. [ABSTRACT FROM AUTHOR]

Published
2014
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49. The relationship between high-sensitive troponin T, neutrophil lymphocyte ratio and SYNTAX Score.

Author

Altun, Burak, Turkon, Hakan, Tasolar, Hakan, Beggı, Halıl, Altun, Mehzat, Temız, Ahmet, Gazı, Emıne, Barutcu, Ahmet, Bekler, Adem, and Colkesen, Yucel

Subjects
TROPONIN, NEUTROPHILS, ACUTE coronary syndrome, MYOCARDIAL infarction, CORONARY angiography
Abstract

Aim. Cardiac troponins are the most preferred biomarkers in the evaluation of acute coronary syndromes (ACS). The aim of our study was to examine the association between high sensitive troponin T (hs-TnT), and neutrophil to lymphocyte ratio (NLR) and the complexity of ACS assessed by SYNTAX Score. Methods and results. 287 patients who underwent coronary angiography were studied (215 male, mean age 62.0 ± 12.7 years). 133 patients were ST elevation myocardial infarction (STEMI), 154 patients were non-ST elevation (NSTE) ACS . The patients are divided to tertiles according to SYNTAX Score; SYNTAX Score ≤ 22 ( n = 122) 22 < SYNTAX Score ≤ 32 ( n = 120), and SYNTAX Score > 32 ( n = 45). NLR was significantly correlated with SYNTAX Score in both STEMI and NSTE-ACS groups ( r = 0.254, p = 0.003, r = 0.419 p < 0.001). Multiple linear regression analysis showed NLR predicted the angiographic severity of ACS assessed by SYNTAX Score in two groups (β = 0.231, p = 0.004; β = 0.232, p = 0.003). Hs-TnT was significantly correlated with SYNTAX Score in two groups ( r = 0.327, p < 0.001; r = 0.430, p < 0.001). Multiple linear regression analysis showed hs-TnT was independent predictor of SYNTAX Score in STEMI and NSTE-ACS patients (β = 0.292, p < 0.001; β = 0.317, p < 0.001). Conclusion. Hs-TnT and NLR were significantly correlated with angiographic severity of ACS assessed by SYNTAX Score. [ABSTRACT FROM AUTHOR]

Published
2014
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