18 results on '"Bartiromo, Fiorina"'
Search Results
2. Vessel Wall MRI: clinical implementation in cerebrovascular disorders—technical aspects
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Cirillo, Luigi, Rustici, Arianna, Toni, Francesco, Zoli, Matteo, Bartiromo, Fiorina, Gramegna, Laura Ludovica, Cicala, Domenico, Tonon, Caterina, Caranci, Ferdinando, and Lodi, Raffaele
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- 2022
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3. Co‐occurrence of glial fibrillary acidic protein astrocytopathy in a patient with Leber's hereditary optic neuropathy due to DNAJC30 mutations.
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Giannoccaro, Maria Pia, Morelli, Luana, Ricciardiello, Fortuna, Donadio, Vincenzo, Bartiromo, Fiorina, Tonon, Caterina, Carbonelli, Michele, Amore, Giulia, Carelli, Valerio, Liguori, Rocco, and La Morgia, Chiara
- Abstract
Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by visual loss, and rarely associated with extraocular manifestations including multiple sclerosis‐like lesions. The association of LHON and neuromyelitis optica spectrum disorders has rarely been reported. Here is reported a case of glial fibrillary acidic protein astrocytopathy presenting with area postrema syndrome in a patient with previously diagnosed recessive LHON due to mutations in the nuclear gene DNAJC30. This case emphasizes the necessity of extensive investigations for other treatable conditions in patients with LHON and otherwise unexplained extraocular involvement and the possibility that also visual symptoms can respond to immune therapy. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer's Disease.
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Sighinolfi, Giovanni, Mitolo, Micaela, Pizzagalli, Fabrizio, Stanzani-Maserati, Michelangelo, Remondini, Daniel, Rochat, Magali Jane, Cantoni, Elena, Venturi, Greta, Vornetti, Gianfranco, Bartiromo, Fiorina, Capellari, Sabina, Liguori, Rocco, Tonon, Caterina, Testa, Claudia, and Lodi, Raffaele
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MILD cognitive impairment ,ALZHEIMER'S disease ,MORPHOMETRICS ,NEUROPSYCHOLOGICAL tests ,SHORT-term memory ,INSPECTION & review - Abstract
Background: Being able to differentiate mild cognitive impairment (MCI) patients who would eventually convert (MCIc) to Alzheimer's disease (AD) from those who would not (MCInc) is a key challenge for prognosis. Objective: This study aimed to investigate the ability of sulcal morphometry to predict MCI progression to AD, dedicating special attention to an accurate identification of sulci. Methods: Twenty-five AD patients, thirty-seven MCI and twenty-five healthy controls (HC) underwent a brain-MR protocol (1.5T scanner) including a high-resolution T1-weighted sequence. MCI patients underwent a neuropsychological assessment at baseline and were clinically re-evaluated after a mean of 2.3 years. At follow-up, 12 MCI were classified as MCInc and 25 as MCIc. Sulcal morphometry was investigated using the BrainVISA framework. Consistency of sulci across subjects was ensured by visual inspection and manual correction of the automatic labelling in each subject. Sulcal surface, depth, length, and width were retrieved from 106 sulci. Features were compared across groups and their classification accuracy in predicting MCI conversion was tested. Potential relationships between sulcal features and cognitive scores were explored using Spearman's correlation. Results: The width of sulci in the temporo-occipital region strongly differentiated between each pair of groups. Comparing MCIc and MCInc, the width of several sulci in the bilateral temporo-occipital and left frontal areas was significantly altered. Higher width of frontal sulci was associated with worse performances in short-term verbal memory and phonemic fluency. Conclusions: Sulcal morphometry emerged as a strong tool for differentiating HC, MCI, and AD, demonstrating its potential prognostic value for the MCI population. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Development of functional MRI protocols in the study of neurodegenerative diseases: MRI study in patients with REM sleep behavior disorder, idiopathic Parkinson's disease and multisystem atrophy
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Bartiromo, Fiorina and Tonon, Caterina
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BIO/12 Biochimica clinica e biologia molecolare e clinica - Abstract
In the central nervous system, iron in several proteins is involved in many important processes: oxygen transportation, oxidative phosphorylation, mitochondrial respiration, myelin production, the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation, modification of lipids, proteins, carbohydrates, and DNA, lead to neurotoxicity. Moreover increased levels of iron are harmful and iron accumulations are typical hallmarks of brain ageing and several neurodegenerative disorders particularly PD. Numerous studies on post mortem tissue report on an increased amount of total iron in the substantia nigra in patients with PD also supported by large body of in vivo findings from Magnetic Resonance Imaging (MRI) studies. The importance and approaches for in vivo brain iron assessment using multiparametric MRI is increased over last years. Quantitative MRI may provide useful biomarkers for brain integrity assessment in iron-related neurodegeneration. Particularly, a prominent change in iron- sensitive T2* MRI contrast within the sub areas of the SN overlapping with nigrosome 1 were shown to be a hallmark of Parkinson's Disease with high diagnostic accuracy. Moreover, differential diagnosis between Parkinson's Disease (PD) and atypical parkinsonian syndromes (APS) remains challenging, mainly in the early phases of the disease. Advanced brain MR imaging enables to detect the pathological changes of nigral and extranigral structures at the onset of clinical manifestations and during the course of the disease. The Nigrosome-1 (N1) is a substructure of the healthy Substantia Nigra pars compacta enriched by dopaminergic neurons; their loss in Parkinson’s disease and atypical parkinsonian syndromes is related to the iron accumulation. N1 changes are supportive MR biomarkers for diagnosis of these neurodegenerative disorders, but its detection is hard with conventional sequences, also using high field (3T) scanner. Quantitative susceptibility mapping (QSM), an iron-sensitive technique, enables the direct detection of Neurodegeneration
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- 2022
6. Temporomesial Glioneuronal Tumors: Epilepsy Surgery
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Giulioni, Marco, Rubboli, Guido, Marucci, Gianluca, Martinoni, Matteo, Bartiromo, Fiorina, Marliani, Anna Federica, Calbucci, Fabio, and Hayat, M.A., editor
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- 2012
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7. Development of functional MRI protocols in the study of neurodegenerative diseases: MRI study in patients with REM sleep behavior disorder, idiopathic Parkinson's disease and multisystem atrophy
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Tonon, Caterina, Bartiromo, Fiorina <1977>, Tonon, Caterina, and Bartiromo, Fiorina <1977>
- Abstract
In the central nervous system, iron in several proteins is involved in many important processes: oxygen transportation, oxidative phosphorylation, mitochondrial respiration, myelin production, the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation, modification of lipids, proteins, carbohydrates, and DNA, lead to neurotoxicity. Moreover increased levels of iron are harmful and iron accumulations are typical hallmarks of brain ageing and several neurodegenerative disorders particularly PD. Numerous studies on post mortem tissue report on an increased amount of total iron in the substantia nigra in patients with PD also supported by large body of in vivo findings from Magnetic Resonance Imaging (MRI) studies. The importance and approaches for in vivo brain iron assessment using multiparametric MRI is increased over last years. Quantitative MRI may provide useful biomarkers for brain integrity assessment in iron-related neurodegeneration. Particularly, a prominent change in iron- sensitive T2* MRI contrast within the sub areas of the SN overlapping with nigrosome 1 were shown to be a hallmark of Parkinson's Disease with high diagnostic accuracy. Moreover, differential diagnosis between Parkinson's Disease (PD) and atypical parkinsonian syndromes (APS) remains challenging, mainly in the early phases of the disease. Advanced brain MR imaging enables to detect the pathological changes of nigral and extranigral structures at the onset of clinical manifestations and during the course of the disease. The Nigrosome-1 (N1) is a substructure of the healthy Substantia Nigra pars compacta enriched by dopaminergic neurons; their loss in Parkinson’s disease and atypical parkinsonian syndromes is related to the iron accumulation. N1 changes are supportive MR biomarkers for diagnosis of these neurodegenerative disorders, but its detection is hard with conventional sequ
- Published
- 2022
8. Follow-Up Assessment of Intracranial Aneurysms Treated with Endovascular Coiling: Comparison of Compressed Sensing and Parallel Imaging Time-of-Flight Magnetic Resonance Angiography
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Vornetti, Gianfranco, primary, Bartiromo, Fiorina, additional, Toni, Francesco, additional, Dall’Olio, Massimo, additional, Cirillo, Mario, additional, Speier, Peter, additional, Princiotta, Ciro, additional, Schmidt, Michaela, additional, Tonon, Caterina, additional, Zacà, Domenico, additional, Lodi, Raffaele, additional, and Cirillo, Luigi, additional
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- 2022
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9. Case Report: Optic Atrophy and Nephropathy With m.13513G>A/MT-ND5 mtDNA Pathogenic Variant
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Barone, Valentina, primary, La Morgia, Chiara, additional, Caporali, Leonardo, additional, Fiorini, Claudio, additional, Carbonelli, Michele, additional, Gramegna, Laura Ludovica, additional, Bartiromo, Fiorina, additional, Tonon, Caterina, additional, Morandi, Luca, additional, Liguori, Rocco, additional, Petrini, Aurelia, additional, Brugnano, Rachele, additional, Del Sordo, Rachele, additional, Covarelli, Carla, additional, Morroni, Manrico, additional, Lodi, Raffaele, additional, and Carelli, Valerio, additional
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- 2022
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10. Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels
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Cani, Ilaria, primary, Sambati, Luisa, additional, Bartiromo, Fiorina, additional, Asioli, Gian Maria, additional, Baiardi, Simone, additional, Belotti, Laura M. B., additional, Giannini, Giulia, additional, Guaraldi, Pietro, additional, Quadalti, Corinne, additional, Romano, Luciano, additional, Lodi, Raffaele, additional, Parchi, Piero, additional, Cortelli, Pietro, additional, Tonon, Caterina, additional, and Calandra‐Buonaura, Giovanna, additional
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- 2022
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11. From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures
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Zoli, Matteo, primary, Talozzi, Lia, additional, Martinoni, Matteo, additional, Manners, David N., additional, Badaloni, Filippo, additional, Testa, Claudia, additional, Asioli, Sofia, additional, Mitolo, Micaela, additional, Bartiromo, Fiorina, additional, Rochat, Magali Jane, additional, Fabbri, Viscardo Paolo, additional, Sturiale, Carmelo, additional, Conti, Alfredo, additional, Lodi, Raffaele, additional, Mazzatenta, Diego, additional, and Tonon, Caterina, additional
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- 2021
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12. Wall motion at 4D-CT angiography and surgical correlation in unruptured intracranial aneurysms: a pilot study
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Ferrari, Fabio, primary, Cirillo, Luigi, additional, Calbucci, Fabio, additional, Bartiromo, Fiorina, additional, Ambrosetto, Paolo, additional, Fioravanti, Antonio, additional, and Leonardi, Marco, additional
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- 2019
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13. Follow-Up Assessment of Intracranial Aneurysms Treated with Endovascular Coiling: Comparison of Compressed Sensing and Parallel Imaging Time-of-Flight Magnetic Resonance Angiography
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Gianfranco Vornetti, Fiorina Bartiromo, Francesco Toni, Massimo Dall’Olio, Mario Cirillo, Peter Speier, Ciro Princiotta, Michaela Schmidt, Caterina Tonon, Domenico Zacà, Raffaele Lodi, Luigi Cirillo, Vornetti, Gianfranco, Bartiromo, Fiorina, Toni, Francesco, Dall’Olio, Massimo, Cirillo, Mario, Speier, Peter, Princiotta, Ciro, Schmidt, Michaela, Tonon, Caterina, Zacà, Domenico, Lodi, Raffaele, and Cirillo, Luigi
- Subjects
cardiovascular system ,Angiography, Digital Subtraction ,Humans ,Intracranial Aneurysm ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,coil embolization ,Embolization, Therapeutic ,Magnetic Resonance Angiography ,eye diseases ,magnetic resonance angiography ,compressed sensing ,intracranial aneurysm ,Follow-Up Studies - Abstract
The aim of our study was to compare compressed sensing (CS) time-of-flight (TOF) magnetic resonance angiography (MRA) with parallel imaging (PI) TOF MRA in the evaluation of patients with intracranial aneurysms treated with coil embolization or stent-assisted coiling. We enrolled 22 patients who underwent follow-up imaging after intracranial aneurysm coil embolization. All patients underwent both PI TOF and CS TOF MRA during the same examination. Image evaluation aimed to compare the performance of CS to PI TOF MRA in determining the degree of aneurysm occlusion, as well as the depiction of parent vessel and vessels adjacent to the aneurysm dome. The reference standard for the evaluation of aneurysm occlusion was PI TOF MRA. The inter-modality agreement between CS and PI TOF MRA in the evaluation of aneurysm occlusion was almost perfect (κ = 0.98, p < 0.001) and the overall inter-rater agreement was substantial (κ = 0.70, p < 0.001). The visualization of aneurysm parent vessel in CS TOF images compared with PI TOF images was evaluated to be better in 11.4%, equal in 86.4%, and worse in 2.3%. CS TOF MRA, with almost 70% scan time reduction with respect to PI TOF MRA, yields comparable results for assessing the occlusion status of coiled intracranial aneurysms. Short scan times increase patient comfort, reduce the risk of motion artifacts, and increase patient throughput, with a resulting reduction in costs. CS TOF MRA may therefore be a potential replacement for PI TOF MRA as a first-line follow-up examination in patients with intracranial aneurysms treated with coil embolization.
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- 2022
14. Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels
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Ilaria Cani, Luisa Sambati, Fiorina Bartiromo, Gian Maria Asioli, Simone Baiardi, Laura M. B. Belotti, Giulia Giannini, Pietro Guaraldi, Corinne Quadalti, Luciano Romano, Raffaele Lodi, Piero Parchi, Pietro Cortelli, Caterina Tonon, Giovanna Calandra‐Buonaura, Cani, Ilaria, Sambati, Luisa, Bartiromo, Fiorina, Asioli, Gian Maria, Baiardi, Simone, Belotti, Laura M B, Giannini, Giulia, Guaraldi, Pietro, Quadalti, Corinne, Romano, Luciano, Lodi, Raffaele, Parchi, Piero, Cortelli, Pietro, Tonon, Caterina, Calandra-Buonaura, Giovanna, Cani I., Sambati L., Bartiromo F., Asioli G.M., Baiardi S., Belotti L.M.B., Giannini G., Guaraldi P., Quadalti C., Romano L., Lodi R., Parchi P., Cortelli P., Tonon C., and Calandra-Buonaura G.
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idiopathic autonomic failure ,Intermediate Filament ,General Neuroscience ,Intermediate Filaments ,Leukoaraiosis ,Biomarker ,White Matter ,Leukoaraiosi ,Cognition ,Retrospective Studie ,Humans ,Neurology (clinical) ,Biomarkers ,Retrospective Studies ,Human - Abstract
Objective: To disclose the nature of cognitive deficits in a cohort of patients with idiopathic autonomic failure (IAF) by exploring the relation among cognitive functions, cardiovascular autonomic failure (AF) and clinical progression to another α-synucleinopathy (phenoconversion). Methods: We retrospectively identified all patients with a clinical diagnosis of IAF who underwent a comprehensive neuropsychological evaluation, clinical examination and cardiovascular autonomic tests from the IAF-BO cohort. Brain magnetic resonance imaging (MRI) studies and cerebrospinal fluid (CSF) analysis, including neurofilament light chain (NfL), Alzheimer disease core biomarkers, and α-synuclein seeding activity were further evaluated when available. Correlations among cognitive functions, clinical features, cardiovascular AF, cerebral white matter hyperintensities (WMH) load, and CSF biomarkers were estimated using Spearman correlation coefficient. Results: Thirteen out of 30 (43%) patients with IAF displayed cognitive deficits (CI) mainly concerning executive functioning. Seven out of 30 (23%) met the criteria for mild cognitive impairment (MCI). The diagnosis of CI and MCI was not associated with phenoconversion or autonomic function parameters, including duration and severity of neurogenic orthostatic hypotension, presence and severity of supine hypertension, and nocturnal dipper profile. Twenty patients underwent a brain MRI and CSF analysis. MCI was related to WMH load (r = 0.549) and NfL levels (r = 0.656), while autonomic function parameters were not associated with either WMH or NfL levels. Interpretation: Cardiovascular AF and phenoconversion, underlying the spreading of neurodegeneration to the central nervous system, were not independent drivers of cognitive dysfunction in IAF. We identified WMH load and NfL levels as potential biomarkers of the neural network disruption associated with cognitive impairment in patients with IAF.
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- 2022
15. From Neurosurgical Planning to Histopathological Brain Tumor Characterization: Potentialities of Arcuate Fasciculus Along-Tract Diffusion Tensor Imaging Tractography Measures
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Matteo Zoli, Lia Talozzi, Matteo Martinoni, David N. Manners, Filippo Badaloni, Claudia Testa, Sofia Asioli, Micaela Mitolo, Fiorina Bartiromo, Magali Jane Rochat, Viscardo Paolo Fabbri, Carmelo Sturiale, Alfredo Conti, Raffaele Lodi, Diego Mazzatenta, Caterina Tonon, Zoli, Matteo, Talozzi, Lia, Martinoni, Matteo, Manners, David N., Badaloni, Filippo, Testa, Claudia, Asioli, Sofia, Mitolo, Micaela, Bartiromo, Fiorina, Rochat, Magali Jane, Fabbri, Viscardo Paolo, Sturiale, Carmelo, Conti, Alfredo, Lodi, Raffaele, Mazzatenta, Diego, and Tonon, Caterina
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Brain tumor ,tractography ,lcsh:RC346-429 ,Temporal lobe ,Glioma ,Medicine ,Arcuate fasciculus ,neurosurgery ,language network ,lcsh:Neurology. Diseases of the nervous system ,Original Research ,business.industry ,Dysembryoplastic Neuroepithelial Tumor ,Parietal lobe ,gliomas grading ,medicine.disease ,fMRI laterality index ,along-tract ,medicine.anatomical_structure ,Neurology ,pre-surgical planning ,arcuate fasciculus ,Neurology (clinical) ,business ,Nuclear medicine ,neurosurgery, tractography, arcuate fasciculus, along-tract, gliomas grading, language network, fMRI laterality index, pre-surgical planning ,Diffusion MRI ,Tractography - Abstract
Background: Tractography has been widely adopted to improve brain gliomas' surgical planning and guide their resection. This study aimed to evaluate state-of-the-art of arcuate fasciculus (AF) tractography for surgical planning and explore the role of along-tract analyses in vivo for characterizing tumor histopathology.Methods: High angular resolution diffusion imaging (HARDI) images were acquired for nine patients with tumors located in or near language areas (age: 41 ± 14 years, mean ± standard deviation; five males) and 32 healthy volunteers (age: 39 ± 16 years; 16 males). Phonemic fluency task fMRI was acquired preoperatively for patients. AF tractography was performed using constrained spherical deconvolution diffusivity modeling and probabilistic fiber tracking. Along-tract analyses were performed, dividing the AF into 15 segments along the length of the tract defined using the Laplacian operator. For each AF segment, diffusion tensor imaging (DTI) measures were compared with those obtained in healthy controls (HCs). The hemispheric laterality index (LI) was calculated from language task fMRI activations in the frontal, parietal, and temporal lobe parcellations. Tumors were grouped into low/high grade (LG/HG).Results: Four tumors were LG gliomas (one dysembryoplastic neuroepithelial tumor and three glioma grade II) and five HG gliomas (two grade III and three grade IV). For LG tumors, gross total removal was achieved in all but one case, for HG in two patients. Tractography identified the AF trajectory in all cases. Four along-tract DTI measures potentially discriminated LG and HG tumor patients (false discovery rate < 0.1): the number of abnormal MD and RD segments, median AD, and MD measures. Both a higher number of abnormal AF segments and a higher AD and MD measures were associated with HG tumor patients. Moreover, correlations (unadjusted p < 0.05) were found between the parietal lobe LI and the DTI measures, which discriminated between LG and HG tumor patients. In particular, a more rightward parietal lobe activation (LI < 0) correlated with a higher number of abnormal MD segments (R = −0.732) and RD segments (R = −0.724).Conclusions: AF tractography allows to detect the course of the tract, favoring the safer-as-possible tumor resection. Our preliminary study shows that along-tract DTI metrics can provide useful information for differentiating LG and HG tumors during pre-surgical tumor characterization.
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- 2021
16. Epilepsy associated tumors: Review article
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Paolo Tinuper, Gianluca Marucci, Patrizia Riguzzi, Ilaria Naldi, Matteo Martinoni, Roberto Michelucci, Marco Giulioni, Lilia Volpi, Agostino Baruzzi, Anna Federica Marliani, Francesca Bisulli, Fiorina Bartiromo, Guido Rubboli, Francesco Toni, Giulioni, Marco, Marucci, Gianluca, Martinoni, Matteo, Marliani, Anna Federica, Toni, Francesco, Bartiromo, Fiorina, Volpi, Lilia, Riguzzi, Patrizia, Bisulli, Francesca, Naldi, Ilaria, Michelucci, Roberto, Baruzzi, Agostino, Tinuper, Paolo, and Rubboli, Guido
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Pathology ,medicine.medical_specialty ,Epilepsy ,business.industry ,Dysembryoplastic Neuroepithelial Tumor ,Leat ,Review ,General Medicine ,Cortical dysplasia ,medicine.disease ,Bioinformatics ,Review article ,Temporal lobe ,Ganglioglioma ,Lesionectomy ,Epilepsy surgery ,Dysembryoplastic neuroepithelial tumor ,medicine ,Long-term epilepsy associated tumor ,Low grade tumors ,business ,Glioneuronal tumor - Abstract
Long-term epilepsy associated tumors (LEAT) represent a well known cause of focal epilepsies. Glioneuronal tumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly arising in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic network with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation.
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- 2014
17. Adverse drug reactions: Dermatological experience
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Fabio Ayala, Fabbrocini, G., Bartiromo, F., Barberio, E., Rescigno, O., Di Simone, L., Capasso, C., Ayala, Fabio, Fabbrocini, Gabriella, Bartiromo, Fiorina, Barberio, Emanuela, Rescigno, Orsola, Simone, Lucia, and C., Capasso
- Subjects
adverse effects, Skin ,Drug response, Pharmaceutical Preparation - Abstract
Aim. Adverse drug reaction (ADRs) monitoring is useful tool for the determination of the negative side effects of drugs from the ethical and practical points of view. It is also a guide to their safest and most efficient use with the aim of improving the quality of healthcare. In addition to their effect on human health, ADRs also impact significantly on healthcare costs. Since ADRs present most frequently with cutaneous signs and symptoms, patients are often referred to dermatologists, who thus come to play a fundamental role in the detection and diagnosis of these reactions, as well as in patient management. Methods. Epidemiological data of 649 patients admitted to the Department of Dermatology of University of Naples Federico II for suspect ADRs were examined. Results. Amongst the ADR identified in our cases, the most frequently observed cutaneous and extracutaneous manifestations were urticaria-angioedema (62%), maculopapular rash (21.4%), loss of consciousness (4.2%), dyspnea (3.7%), anaphylactic shock (2.5%), nausea (1.8%), itching (1.5%), stomatitis (1.1%), Stevens-Johnson's syndrome (0.6%), paraesthesia (0.3%), erythema nodosum (0.3%), fixed eruption (0.3%), epistaxis (0.3%). ADRs were more often triggered by the following therapeutic categories: antibiotic agents (45%), antipyretic and analgesic drugs (23%), non steroidal anti-inflammatory drugs (28%). Conclusion. The widespread use of these drugs justifies the importance of drug-surveillance activity, aimed at decreasing the negative effects of liberal drug use and at increasing their safety.
18. Epilepsy associated tumors: Review article.
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Giulioni M, Marucci G, Martinoni M, Marliani AF, Toni F, Bartiromo F, Volpi L, Riguzzi P, Bisulli F, Naldi I, Michelucci R, Baruzzi A, Tinuper P, and Rubboli G
- Abstract
Long-term epilepsy associated tumors (LEAT) represent a well known cause of focal epilepsies. Glioneuronal tumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly arising in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic network with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation.
- Published
- 2014
- Full Text
- View/download PDF
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