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13. Systematic Analysis of Viral and Cellular MicroRNA Targets in Cells Latently Infected with Human γ-Herpesviruses by RISC Immunoprecipitation Assay

Author

Dölken, Lars, Malterer, Georg, Erhard, Florian, Kothe, Sheila, Friedel, Caroline C., Suffert, Guillaume, Marcinowski, Lisa, Motsch, Natalie, Barth, Stephanie, Beitzinger, Michaela, Lieber, Diana, Bailer, Susanne M., Hoffmann, Reinhard, Ruzsics, Zsolt, Kremmer, Elisabeth, Pfeffer, Sébastien, Zimmer, Ralf, Koszinowski, Ulrich H., Grässer, Friedrich, Meister, Gunter, and Haas, Jürgen

Published
2010
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20. microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma

Author

Imig, Jochen, Motsch, Natalie, Zhu, Jia Yun, Barth, Stephanie, Okoniewski, Michal, Reineke, Tanja, Tinguely, Marianne, Faggioni, Alberto, Trivedi, Pankaj, Meister, Gunter, Renner, Christoph, Grässer, Friedrich A., Imig, Jochen, Motsch, Natalie, Zhu, Jia Yun, Barth, Stephanie, Okoniewski, Michal, Reineke, Tanja, Tinguely, Marianne, Faggioni, Alberto, Trivedi, Pankaj, Meister, Gunter, Renner, Christoph, and Grässer, Friedrich A.

Abstract

The Epstein-Barr virus (EBV) is an oncogenic human Herpes virus found in ∼15% of diffuse large B-cell lymphoma (DLBCL). EBV encodes miRNAs and induces changes in the cellular miRNA profile of infected cells. MiRNAs are small, non-coding RNAs of ∼19-26 nt which suppress protein synthesis by inducing translational arrest or mRNA degradation. Here, we report a comprehensive miRNA-profiling study and show that hsa-miR-424, -223, -199a-3p, -199a-5p, -27b, -378, -26b, -23a, -23b were upregulated and hsa-miR-155, -20b, -221, -151-3p, -222, -29b/c, -106a were downregulated more than 2-fold due to EBV-infection of DLBCL. All known EBV miRNAs with the exception of the BHRF1 cluster as well as EBV-miR-BART15 and -20 were present. A computational analysis indicated potential targets such as c-MYB, LATS2, c-SKI and SIAH1. We show that c-MYB is targeted by miR-155 and miR-424, that the tumor suppressor SIAH1 is targeted by miR-424, and that c-SKI is potentially regulated by miR-155. Downregulation of SIAH1 protein in DLBCL was demonstrated by immunohistochemistry. The inhibition of SIAH1 is in line with the notion that EBV impedes various pro-apoptotic pathways during tumorigenesis. The down-modulation of the oncogenic c-MYB protein, although counter-intuitive, might be explained by its tight regulation in developmental processes

Published
2017

21. MicroRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma

Author

Kwanhian, Wiyada, Lenze, Dido, Alles, Julia, Motsch, Natalie, Barth, Stephanie, Döll, Celina, Imig, Jochen, Hummel, Michael, Tinguely, Marianne, Trivedi, Pankaj, Lulitanond, Viraphong, Meister, Gunter, Renner, Christoph, Grässer, Friedrich A, University of Zurich, and Grässer, Friedrich A

Subjects
10049 Institute of Pathology and Molecular Pathology, 10032 Clinic for Oncology and Hematology, 2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research
Published
2012

22. Expression of neuropeptide Y, omentin and visfatin in visceral andsubcutaneous adipose tissues in humans: relation to endocrine and clinical parameters

Author

Barth, Stephanie

Subjects
Hydrocortison, Fettsucht, Medizinische Fakultät -ohne weitere Spezifikation, ddc:610, Neuropeptid Y
Abstract

Hintergrund und Ziele: Adipozytokine spielen in der Pathogenese humaner Adipositas eine wesentliche Rolle. Des Weiteren sind sie mit kardiovaskulären bzw. metabolischen Risikofaktoren assoziiert. Das Ziel unserer Studie war es, die Genexpression von Omentin, Visfatin und Neuropeptid Y (NPY) in humanem Fettgewebe Erwachsener zu bestimmen. Ferner erhoben wir klinische Parameter und untersuchten die Konzentrationen von NPY im Plasma und Kortisol im Serum, um letztere mit Urinsteroiden bei adipösen und normalgewichtigen Erwachsenen und adipösen Kindern zu vergleichen. Methoden: Unsere Studienpopulation bestand aus 133 adipösen und normalgewichtigen Erwachsenen sowie aus 56 adipösen Kindern. Mithilfe von Real-time-PCR bestimmten wir die Expression von Omentin, Visfatin und NPY in subkutanem und viszeralem Fettgewebe von 62 erwachsenen adipösen und normalgewichtigen Probanden, die sich einer elektiven laparoskopischen Operation unterzogen hatten. Darüber hinaus bestimmten wir klinische Parameter, NPY-Plasmakonzentrationen (mittels Radioimmunoassay), Serumkortisolkonzentrationen (mittels ECLIA) und Kortisolmetabolite im Urin (mittels GC-MS). Ergebnisse: In viszeralem Fettgewebe konnten wir eine höhere Omentin-Genexpression feststellen als in subkutanem Fettgewebe. Die Visfatin-Genexpression war in subkutanem Fettgewebe adipöser Patienten reduziert (p

Published
2010

24. BASICS Ernährungsmedizin

Author

Barth Stephanie and Barth Stephanie

Subjects
Nutrition
Abstract

Verloren im Dickicht der Überinformation? Schluss mit dem Stress: Mit der BASICS-Reihe gewinnen Sie den Überblick! Gut Von den Grundlagen über die häufigsten Erkrankungen bis zur Therapie. Besser Mit klinischen Fallbeispielen. Basics: jedes Thema in kleinen Häppchen auf je einer Doppelseite. Schön in Farbe, prima zu lesen und mit vielen Versteh-Bildern im typischen'Basics'-Stil BASICS: das Wesentliche zum Thema in leicht verständlicher Formschnell fit für Praktika, Famulaturen und bed-side-teaching-Kursefächerübergreifendes Wissen - ideal zum Lernen nach der neuen AO

Published
2009

26. MicroRNA‐142 is mutated in about 20% of diffuse large B‐cell lymphoma

Author

Kwanhian, Wiyada, primary, Lenze, Dido, additional, Alles, Julia, additional, Motsch, Natalie, additional, Barth, Stephanie, additional, Döll, Celina, additional, Imig, Jochen, additional, Hummel, Michael, additional, Tinguely, Marianne, additional, Trivedi, Pankaj, additional, Lulitanond, Viraphong, additional, Meister, Gunter, additional, Renner, Christoph, additional, and Grässer, Friedrich A., additional

Published
2012
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28. Binding of the Heterogeneous Ribonucleoprotein K (hnRNP K) to the Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Enhances Viral LMP2A Expression

Author

Gross, Henrik, primary, Hennard, Christine, additional, Masouris, Ilias, additional, Cassel, Christian, additional, Barth, Stephanie, additional, Stober-Grässer, Ute, additional, Mamiani, Alfredo, additional, Moritz, Bodo, additional, Ostareck, Dirk, additional, Ostareck-Lederer, Antje, additional, Neuenkirchen, Nils, additional, Fischer, Utz, additional, Deng, Wen, additional, Leonhardt, Heinrich, additional, Noessner, Elfriede, additional, Kremmer, Elisabeth, additional, and Grässer, Friedrich A., additional

Published
2012
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29. microRNA profiling in Epstein–Barr virus-associated B-cell lymphoma

Author

Imig, Jochen, primary, Motsch, Natalie, additional, Zhu, Jia Yun, additional, Barth, Stephanie, additional, Okoniewski, Michal, additional, Reineke, Tanja, additional, Tinguely, Marianne, additional, Faggioni, Alberto, additional, Trivedi, Pankaj, additional, Meister, Gunter, additional, Renner, Christoph, additional, and Grässer, Friedrich A., additional

Published
2010
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30. Abstract 4036: The microRNA profile of prostate carcinoma obtained by deep sequencing reveals potential miRNA targets such as myosin VI

Author

Szczyrba, Jaroslaw, primary, Löprich, Elke, additional, Wach, Sven, additional, Jung, Volker, additional, Unteregger, Gerhard, additional, Barth, Stephanie, additional, Grobholz, Rainer, additional, Wieland, Wolf, additional, Stöhr, Robert, additional, Hartmann, Arndt, additional, Wullich, Bernd, additional, and Grässer, Friedrich, additional

Published
2010
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31. The MicroRNA Profile of Prostate Carcinoma Obtained by Deep Sequencing

Author

Szczyrba, Jaroslaw, primary, Löprich, Elke, additional, Wach, Sven, additional, Jung, Volker, additional, Unteregger, Gerhard, additional, Barth, Stephanie, additional, Grobholz, Rainer, additional, Wieland, Wolf, additional, Stöhr, Robert, additional, Hartmann, Arndt, additional, Wullich, Bernd, additional, and Grässer, Friedrich, additional

Published
2010
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35. RNA-Dependent Gene Silencing and Epigenetics in Animals.

Author

Gross, H. J., Nellen, Wolfgang, Hammann, Christian, Paulsen, Martina, Tierling, Sascha, Barth, Stephanie, and Walter, Jörn

Abstract

In animals noncoding RNAs are involved in a large variety of gene silencing mechanisms. These include post-transcriptional RNA interference (RNAi) that is mediated by small double-stranded RNAs and results in degradation of messenger RNAs as well as epigenetic silencing of genes. RNAi as a naturally occurring silencing mechanism has been well investigated in various eukaryotic organisms. Sequencing of the human and mouse genomes and careful analyses of the related transcriptomes led to the identification of some hundred microRNAs that might regulate endogenous gene expression by RNAi-like mechanisms or repression of translation. In mammals the major protein components of the RNAi machinery have been identified, and RNAi has become a tool for artificial gene silencing in mammalian systems. There is also evidence that in mammalian cells genes can be regulated by noncoding antisense transcripts that are transcribed from the opposite DNA strand. Besides their potential roles in RNAi and repression of translation, short double-stranded RNAs and also long noncoding RNAs are involved in epigenetic gene silencing. In this chapter we give an overview of prominent features of naturally occurring RNAi and also of the potential role of RNAs in epigenetic gene silencing mechanisms in animals, especially in mammals. [ABSTRACT FROM AUTHOR]

Published
2006
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37. MicroRNA Profiling of Epstein-Barr Virus-Associated NK/ T-Cell Lymphomas by Deep Sequencing.

Author

Motsch, Natalie, Alles, Julia, Imig, Jochen, Zhu, Jiayun, Barth, Stephanie, Reineke, Tanja, Tinguely, Marianne, Cogliatti, Sergio, Dueck, Anne, Meister, Gunter, Renner, Christoph, Grässer, Friedrich A., and Xin-yuan Guan

Subjects
EPSTEIN-Barr virus, T-cell lymphoma, MICRORNA, RNA, GENE expression, THYMUS, LYMPHOMAS
Abstract

The Epstein-Barr virus (EBV) is an oncogenic human Herpes virus involved in the pathogenesis of nasal NK/T-cell lymphoma. EBV encodes microRNAs (miRNAs) and induces changes in the host cellular miRNA profile. MiRNAs are short non- coding RNAs of about 19-25 nt length that regulate gene expression by post- transcriptional mechanisms and are frequently deregulated in human malignancies including cancer. The microRNA profiles of EBV-positive NK/T-cell lymphoma, non- infected T-cell lymphoma and normal thymus were established by deep sequencing of small RNA libraries. The comparison of the EBV-positive NK/T-cell vs. EBV- negative T-cell lymphoma revealed 15 up- und 16 down-regulated miRNAs. In contrast, the majority of miRNAs was repressed in the lymphomas compared to normal tissue. We also identified 10 novel miRNAs from known precursors and two so far unknown miRNAs. The sequencing results were confirmed for selected miRNAs by quantitative Real-Time PCR (qRT-PCR). We show that the proinflammatory cytokine interleukin 1 alpha (IL1A) is a target for miR-142-3p and the oncogenic BCL6 for miR-205. MiR-142-3p is down-regulated in the EBV-positive vs. EBV- negative lymphomas. MiR-205 was undetectable in EBV-negative lymphoma and strongly down-regulated in EBV-positive NK/T-cell lymphoma as compared to thymus. The targets were confirmed by reporter assays and by down-regulation of the proteins by ectopic expression of the cognate miRNAs. Taken together, our findings demonstrate the relevance of deregulated miRNAs for the post- transcriptional gene regulation in nasal NK/T-cell lymphomas. [ABSTRACT FROM AUTHOR]

Published
2012
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38. microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma

Author

Imig, Jochen, Motsch, Natalie, Zhu, Jia Yun, Barth, Stephanie, Okoniewski, Michal, Reineke, Tanja, Tinguely, Marianne, Faggioni, Alberto, Trivedi, Pankaj, Meister, Gunter, Renner, Christoph, and Grässer, Friedrich A.

Subjects
hemic and lymphatic diseases, 3. Good health
Abstract

The Epstein–Barr virus (EBV) is an oncogenic human Herpes virus found in ∼15% of diffuse large B-cell lymphoma (DLBCL). EBV encodes miRNAs and induces changes in the cellular miRNA profile of infected cells. MiRNAs are small, non-coding RNAs of ∼19–26 nt which suppress protein synthesis by inducing translational arrest or mRNA degradation. Here, we report a comprehensive miRNA-profiling study and show that hsa-miR-424, -223, -199a-3p, -199a-5p, -27b, -378, -26b, -23a, -23b were upregulated and hsa-miR-155, -20b, -221, -151-3p, -222, -29b/c, -106a were downregulated more than 2-fold due to EBV-infection of DLBCL. All known EBV miRNAs with the exception of the BHRF1 cluster as well as EBV-miR-BART15 and -20 were present. A computational analysis indicated potential targets such as c-MYB, LATS2, c-SKI and SIAH1. We show that c-MYB is targeted by miR-155 and miR-424, that the tumor suppressor SIAH1 is targeted by miR-424, and that c-SKI is potentially regulated by miR-155. Downregulation of SIAH1 protein in DLBCL was demonstrated by immunohistochemistry. The inhibition of SIAH1 is in line with the notion that EBV impedes various pro-apoptotic pathways during tumorigenesis. The down-modulation of the oncogenic c-MYB protein, although counter-intuitive, might be explained by its tight regulation in developmental processes., Nucleic Acids Research, 39 (5), ISSN:1362-4962, ISSN:0301-5610

39. microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma

Author

Imig, Jochen, Motsch, Natalie, Zhu, Jia Yun, Barth, Stephanie, Okoniewski, Michal, Reineke, Tanja, Tinguely, Marianne, Faggioni, Alberto, Trivedi, Pankaj, Meister, Gunter, Renner, Christoph, Grässer, Friedrich A., Imig, Jochen, Motsch, Natalie, Zhu, Jia Yun, Barth, Stephanie, Okoniewski, Michal, Reineke, Tanja, Tinguely, Marianne, Faggioni, Alberto, Trivedi, Pankaj, Meister, Gunter, Renner, Christoph, and Grässer, Friedrich A.

Abstract

The Epstein-Barr virus (EBV) is an oncogenic human Herpes virus found in ∼15% of diffuse large B-cell lymphoma (DLBCL). EBV encodes miRNAs and induces changes in the cellular miRNA profile of infected cells. MiRNAs are small, non-coding RNAs of ∼19-26 nt which suppress protein synthesis by inducing translational arrest or mRNA degradation. Here, we report a comprehensive miRNA-profiling study and show that hsa-miR-424, -223, -199a-3p, -199a-5p, -27b, -378, -26b, -23a, -23b were upregulated and hsa-miR-155, -20b, -221, -151-3p, -222, -29b/c, -106a were downregulated more than 2-fold due to EBV-infection of DLBCL. All known EBV miRNAs with the exception of the BHRF1 cluster as well as EBV-miR-BART15 and -20 were present. A computational analysis indicated potential targets such as c-MYB, LATS2, c-SKI and SIAH1. We show that c-MYB is targeted by miR-155 and miR-424, that the tumor suppressor SIAH1 is targeted by miR-424, and that c-SKI is potentially regulated by miR-155. Downregulation of SIAH1 protein in DLBCL was demonstrated by immunohistochemistry. The inhibition of SIAH1 is in line with the notion that EBV impedes various pro-apoptotic pathways during tumorigenesis. The down-modulation of the oncogenic c-MYB protein, although counter-intuitive, might be explained by its tight regulation in developmental processes

40. Erfolgsfaktor Spaβ: Mitarbeiterbegeisterung kommt in der Unternehmenskultur oft zu kurz.

Author

Barth, Stephanie

Abstract

Copyright of Wissens Management is the property of Nicole Lehnert - wissensmanagement and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

41. Mildred Andrews Boggess: A Biography

Author

Barth, Stephanie

Subjects
Music., Organist., Biography., Teacher.
Abstract

Mildred Morford Andrews Boggess (1915-1987) was an outstanding twentieth century organ teacher and performer. She was the highest-honored Professor of Music at the University of Oklahoma between June 1938 to June 1976. She produced at least twelve Fulbright Fellowship scholars and many winners at national or regional performance competitions. Boggess was inducted into the Oklahoma Hall of Fame in 1971. Upon her retirement in 1976, headlines read: “The End of an Era,” “Winningest Coach of the Console,” and “The Legend Ends.” Her dedication to the University and the arts was such that head football coach Barry Switzer, Oklahoma Governor David Boren, Congressman Tom Steed, House Speaker Carl Albert, President Gerald Ford, and Vice President Nelson Rockefeller all extended their congratulations to her. This thesis is the first academic publication based upon her biographical materials. It includes an analysis of her pedagogical methods and impact upon sacred music in the twentieth century, in relation to prevailing ideology at the time and the Organ Reform Movement.

Published
2017

42. SOUTHWEST DIVISION.

Author

GARDNER, JILLIAN, BARTH, STEPHANIE, HEROD, LOGAN, MCMAINS, CONNER, and CROCE, GREGORY SANTA

Subjects
*KEYBOARD instruments, *MENTAL health, *EXERCISE, *PERFORMANCE
Abstract

The article discusses the keyboard performance issues focused on by the Young Organists Southwest Division of the organization American Guild of Organists (AGO), which include healthy eating, emotional wellness and efficient exercises.

Published
2017

43. Identification of Novel Epstein-Barr Virus MicroRNA Genes from Nasopharyngeal Carcinomas.

Author

Jia Yun Zhu, Pfuhl, Thorsten, Motsch, Natalie, Barth, Stephanie, Nicholls, John, Grässer, Friedrich, and Meister, Gunter

Subjects
*EPSTEIN-Barr virus, *MESSENGER RNA, *NUCLEOTIDES, *METABOLISM, *GENES, *CANCER
Abstract

MicroRNAs (miRNAs) represent a conserved class of small noncoding RNAs that are found in all higher eukaryotes as well as some DNA viruses. miRNAs are 20 to 25 nucleotides in length and have important regulatory functions in biological processes such as embryonic development, cell differentiation, hormone secretion, and metabolism. Furthermore, miRNAs have been implicated in the pathology of various diseases, including cancer. miRNA expression profiles not only classify different types of cancer but also may even help to characterize distinct tumor stages, therefore constituting a valuable tool for prognosis. Here we report the miRNA profile of Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) tissue samples characterized by cloning and sequencing. We found that all EBV miRNAs from the BART region are expressed in NPC tissues, whereas EBV miRNAs from the BHRF1 region are not found. Moreover, we identified two novel EBV miRNA genes originating from the BART region that have not been found in other tissues or cell lines before. We also identified three new human miRNAs which might be specific for nasopharyngeal tissues. We further show that a number of different cellular miRNAs, including miR-15a and miR-16, are up- or downregulated in NPC tissues compared to control tissues. We found that the tumor suppressor BRCA-1 is a target of miR-15a as well as miR-16, suggesting a miRNA role in NPC pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2009
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