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205 results on '"Bartenschlager, H."'

2. Comparison of Vietnamese and European pig breeds using microsatellites

Author

Thuy, N.T.D., Melchinger-Wild, E., Kuss, A.W., Cuong, N.V., Bartenschlager, H., and Geldermann, H.

Subjects
Swine -- Research, Swine -- Comparative analysis, Zoology and wildlife conservation
Abstract

This study characterized autochthonous pig breeds of Vietnam and compared them with breeds from other regions. A total of 343 animals were considered from 5 indigenous pig breeds of Vietnam (Muong Khuong, Co, Meo, Tap Na, and Mong Cai), 2 exotic breeds kept in Vietnam (Landrace and Yorkshire), 3 European commercial breeds (German Landrace, Pietrain, and Large White), the Chinese breed Meishan, and the European Wild Boar. Each individual was genotyped for 20 selected polymorphic microsatellite loci. The Vietnamese autochthonous breeds showed higher degrees of polymorphism, allelic diversity, and heterozygosity than the other pig breeds. Also, large genetic diversity was observed across the area of distribution, with village-specific subpopulations, which led to significant inbreeding coefficients. As expected, genetic distances showed large differences among European-based, Chinese, and Vietnamese indigenous breeds and reflected the geographical distribution of breeds. In comparison with the European breeds, the Vietnamese indigenous pig breeds harbored a considerable amount of genetic diversity and, therefore, will be of significance for livestock bioconservation. Key words: genetic distance, genetic diversity, microsatellite, pig breed

Published
2006

3. Large-scale, multibreed, multitrait analyses of quantitative trait loci experiments: The case of porcine X chromosome

Author

Perez-Enciso, M., Mercade, A., Bidanel, J.P., Geldermann, H., Cepica, S., Bartenschlager, H., Varona, L., Milan, D., and Folch, J.M.

Subjects
Swine -- Genetic aspects, Swine -- Research, Genetic research, Zoology and wildlife conservation
Abstract

A QTL analysis of multibreed experiments (i.e., crossed populations involving more than two founder breeds) offers clear advantages over classical two-breed crosses, among them increased power and a more comprehensive coverage of the total genetic variability in the species. An alternative to designed multibreed crosses is to reanalyze jointly several experiments involving different breeds. We report a multibreed, multitrait QTL analysis of SSCX that involves five different crosses, six breeds, and almost 3,000 genotyped individuals using a truly multibreed strategy to allow for any number of founder breed origins. Traits analyzed were growth, fat thickness, car-cass length, and shoulder and ham weights. Generally, the joint analysis resulted in more significant QTL than the single-experiment analyses. We show that the QTL for fatness, which is highly significant (nominal P < [10.sup.-43]), is of Asiatic origin (Meishan). The next most significant QTL (nominal P < [10.sup.15]) affected ham weight and seems to be segregating only between Large White and the rest of the breeds. A multitrait, multi-QTL analysis suggests that these are two distinct loci. Additionally, a locus segregating only between Iberian and Landrace affects live weight. The advantages of joint, multibreed analyses clearly outweigh their potential risks. Key Words: Fatness, Growth, Pig, Quantitative Trait Locus, Sex Chromosome

Published
2005

21. Porcine PPARGC1A (peroxisome proliferative activated receptor gamma coactivator 1A): coding sequence, genomic organization, polymorphisms and mapping

Author

Jacobs, K., Rohrer, G. A., Poucke, M., Francois PIUMI, Manon Yerle, Bartenschlager, H., Mattheews, M., Zeveren, A., Peelman, L. J., Laboratoire de radiobiologie et d'étude du génome (LREG), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], GENE PPARGC1A, [SDV]Life Sciences [q-bio], PIGS, PPARGC1A GENE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

24. Polymorphism, linkage mapping, and association analysis with carcass traits of four porcine candidate genes selected from gene-expression profiles of Czech Large White and Wild Boar muscles

Author

Chalupová, P., primary, Dvořáková, V., additional, Knoll, A., additional, Stratil, A., additional, Bartenschlager, H., additional, Stupka, R., additional, Čítek, J., additional, Šprysl, M., additional, Palánová, A., additional, Horák, P., additional, and Geldermann, H., additional

Published
2014
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25. A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C.

Author

Jensen, L.R., Bartenschlager, H., Rujirabanjerd, S., Tzschach, A., Numann, A., Janecke, A.R., Sporle, R., Stricker, S., Raynaud, M., Nelson, J., Hackett, A., Fryns, J.P., Chelly, J., Brouwer, A.P.M. de, Hamel, B.C.J., Gecz, J., Ropers, H.H., Kuss, A.W., Jensen, L.R., Bartenschlager, H., Rujirabanjerd, S., Tzschach, A., Numann, A., Janecke, A.R., Sporle, R., Stricker, S., Raynaud, M., Nelson, J., Hackett, A., Fryns, J.P., Chelly, J., Brouwer, A.P.M. de, Hamel, B.C.J., Gecz, J., Ropers, H.H., and Kuss, A.W.

Abstract

Contains fulltext : 89231.pdf (publisher's version ) (Open Access), BACKGROUND: Mental retardation is a genetically heterogeneous disorder, as more than 90 genes for this disorder has been found on the X chromosome alone. In addition the majority of patients are non-syndromic in that they do not present with clinically recognisable features. This makes it difficult to determine the molecular cause of this disorder on the basis of the phenotype alone. Mutations in KDM5C (previously named SMCX or JARID1C), a gene that encodes a transcriptional regulator with histone demethylase activity specific for dimethylated and trimethylated H3K4, are a comparatively frequent cause of non-syndromic X-linked mental retardation (NS-XLMR). Specific transcriptional targets of KDM5C, however, are still unknown and the effects of KDM5C deficiency on gene expression have not yet been investigated. RESULTS: By whole-mount in situ hybridisation we showed that the mouse homologue of KDM5C is expressed in multiple tissues during mouse development.We present the results of gene expression profiling performed on lymphoblastoid cell lines as well as blood from patients with mutations in KDM5C. Using whole genome expression arrays and quantitative reverse transcriptase polymerase chain reaction (QRT-PCR) experiments, we identified several genes, including CMKOR1, KDM5B and KIAA0469 that were consistently deregulated in both tissues. CONCLUSIONS: Our findings shed light on the pathological mechanisms underlying mental retardation and have implications for future diagnostics of this heterogeneous disorder.

Published
2010

26. Porcine NAMPT gene Search for polymorphism, mapping and association studies

Author

López, Adrián [0000-0002-8649-750X], Fernández, Almudena [0000-0002-4495-9366], Čepica, S., Bartenschlager, H., Óvilo Martín, Cristina, Zrůstová, J., Masopust, M., Fernández, Almudena, López, Adrián, Knoll, A., Rohrer, G. A., Snelling, W. M., Geldermann, H., López, Adrián [0000-0002-8649-750X], Fernández, Almudena [0000-0002-4495-9366], Čepica, S., Bartenschlager, H., Óvilo Martín, Cristina, Zrůstová, J., Masopust, M., Fernández, Almudena, López, Adrián, Knoll, A., Rohrer, G. A., Snelling, W. M., and Geldermann, H.

Abstract

NAMPT encodes an enzyme catalysing the rate-limiting step in NAD biosynthesis. The extracellular form of the enzyme is known as adipokine visfatin. We detected SNP AM999341g.669T>C (referred to as 669T>C) in intron 9 and SNP FN392209g.358A>G (referred to as 358A>G) in the promoter of the gene. RH mapping linked the gene to microsatellite SW944. Linkage analysis placed the gene on the current USDA - USMARC linkage map at position 92 cM on SSC9. Association analyses were performed in a wild boar × Meishan F2 family (W × M), with 45 traits recorded (growth and fattening, fat deposition, muscling, meat quality, stress resistance and other traits), and in a commercial Landrace × Chinese-European (LCE) synthetic population with records for 15 traits (growth, fat deposition, muscling, intramuscular fat, meat colour and backfat fatty acid content). In the W × M, SNP 669T>C was associated with muscling, fat deposition, growth and fattening, meat quality and other traits and in the LCE with muscling, meat quality and backfat fatty acid composition. In the W × M, SNP 358A>G was associated with muscling, fat deposition, growth and other traits. After correction for multiple testing, the NAMPT haplotypes were associated in the W × M with, in descending order, muscling (q = 0.0056), growth (q = 0.0056), fat deposition (q = 0.0109), fat-to-meat ratio (q = 0.0135), cooling losses (q = 0.0568) and longissimus pHU (q = 0.0695). The SNPs are hypothesized to be in linkage disequilibrium with a causative mutation affecting energy metabolism as a whole rather than fat metabolism alone. © 2010 Stichting International Foundation for Animal Genetics.

Published
2010

32. Linkage and QTL mapping for Sus scrofa chromosome 13

Author

Yue, G., primary, Russo, V., additional, Davoli, R., additional, Sternstein, I., additional, Brunsch, C., additional, Schroffelova, D., additional, Stratil, A., additional, Moser, G., additional, Bartenschlager, H., additional, Reiner, G., additional, and Geldermann, H., additional

Published
2003
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34. Linkage and QTL mapping for Sus scrofa chromosome 7

Author

Yue, G., primary, Stratil, A., additional, Cepica, S., additional, Schroffel, J., additional, Schroffelova, D., additional, Fontanesi, L., additional, Cagnazzo, M., additional, Moser, G., additional, Bartenschlager, H., additional, Reiner, G., additional, and Geldermann, H., additional

Published
2003
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35. Linkage and QTL mapping for Sus scrofa chromosome 9

Author

Cepica, S., primary, Schröffel, J., additional, Stratil, A., additional, Hojný, J., additional, Pierzchala, M., additional, Kuryl, J., additional, Brunsch, C., additional, Sternstein, I., additional, Davoli, R., additional, Fontanesi, L., additional, Reiner, G., additional, Bartenschlager, H., additional, Moser, G., additional, and Geldermann, H., additional

Published
2003
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38. Linkage and QTL mapping for Sus scrofa chromosome 6

Author

Yue, G., primary, Stratil, A., additional, Kopecny, M., additional, Schroffelova, D., additional, Schroffel, J., additional, Hojny, J., additional, Cepica, S., additional, Davoli, R., additional, Zambonelli, P., additional, Brunsch, C., additional, Sternstein, I., additional, Moser, G., additional, Bartenschlager, H., additional, Reiner, G., additional, and Geldermann, H., additional

Published
2003
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40. Linkage and QTL mapping for Sus scrofa chromosome 4

Author

Cepica, S., primary, Stratil, A., additional, Kopecny, M., additional, Blazkova, P., additional, Schroffel, J., additional, Davoli, R., additional, Fontanesi, L., additional, Reiner, G., additional, Bartenschlager, H., additional, Moser, G., additional, and Geldermann, H., additional

Published
2003
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