268 results on '"Bartels, Michael J."'
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2. Use of a probabilistic PBPK/PD model to calculate Data Derived Extrapolation Factors for chlorpyrifos
3. Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment
4. LC–MS/MS simultaneous quantitation of 2-hydroxyethylated, oxidative, and unmodified DNA nucleosides in DNA isolated from tissues of mice after exposure to ethylene oxide
5. A human life-stage physiologically based pharmacokinetic and pharmacodynamic model for chlorpyrifos: Development and validation
6. Quantitation of 4,4′-methylene diphenyl diisocyanate human serum albumin adducts
7. Measurement of deoxyinosine adduct: Can it be a reliable tool to assess oxidative or nitrosative DNA damage?
8. Direct quantitation of hydroxyethylvaline in hemoglobin by liquid chromatography/positive electrospray tandem mass spectrometry
9. TK Modeler version 1.0, a Microsoft® Excel®-based modeling software for the prediction of diurnal blood/plasma concentration for toxicokinetic use
10. Statistical methodology to determine kinetically derived maximum tolerated dose in repeat dose toxicity studies
11. Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing – An integrated approach without additional animal use
12. Use of toxicokinetics to support chemical evaluation: Informing high dose selection and study interpretation
13. Development of a source-to-outcome model for dietary exposures to insecticide residues: An example using chlorpyrifos
14. Application of a source-to-outcome model for the assessment of health impacts from dietary exposures to insecticide residues
15. In vitro metabolism and covalent binding of ethylbenzene to microsomal protein as a possible mechanism of ethylbenzene-induced mouse lung tumorigenesis
16. Dose–response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU
17. Letter to the editor regarding Heringa et al. (2020) paper entitled “Use of the Kinetically-derived Maximum Dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management”
18. Guidelines for the communication of Biomonitoring Equivalents: Report from the Biomonitoring Equivalents Expert Workshop
19. Guidelines for the derivation of Biomonitoring Equivalents: Report from the Biomonitoring Equivalents Expert Workshop
20. Agreement of pesticide biomarkers between morning void and 24-h urine samples from farmers and their children
21. Chlorpyrifos exposure in farm families: Results from the farm family exposure study
22. Biomonitoring of 2,4-dichlorophenoxyacetic acid exposure and dose in farm families
23. LC-MS Bioanalysis of Intracellular Drugs
24. Industrial Applications of High-Resolution GC/MS
25. Ethylene glycol: an estimate of tolerable levels of exposure based on a review of animal and human data
26. Simultaneous quantitation of 7-methyl- and O 6-methylguanine adducts in DNA by liquid chromatography–positive electrospray tandem mass spectrometry
27. Authors response to Huff et al., “Clarifying carcinogenicity of ethylbenzene”
28. Metabolic Basis for Nonlinearity in 1,3-Dichloropropene Toxicokinetics and Use in Setting a Kinetically-derived Maximum Inhalation Exposure Concentration in Mice
29. The Effect of Plasma Lipids on the Pharmacokinetics of Chlorpyrifos and the Impact on Interpretation of Blood Biomonitoring Data
30. Mechanism of Ethylbenzene-Induced Mouse-Specific Lung Tumor: Metabolism of Ethylbenzene by Rat, Mouse, and Human Liver and Lung Microsomes
31. Investigation of the formation of N-nitrosodiethanolamine in B6C3F1 mice following topical administration of triethanolamine
32. Dynamic Changes in Lipids and Proteins of Maternal, Fetal, and Pup Blood and Milk during Perinatal Development in CD and Wistar Rats
33. The Effect of Route, Vehicle, and Divided Doses on the Pharmacokinetics of Chlorpyrifos and Its Metabolite Trichloropyridinol in Neonatal Sprague-Dawley Rats
34. Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies
35. Incorporation of S-9 activation into an ER-α transactivation assay ☆
36. Metabolic Basis for Nonlinearity in 1,3-Dichloropropene Toxicokinetics and Use in Setting a Kinetically-derived Maximum Inhalation Exposure Concentration in Mice.
37. Chapter 17 - Industrial Applications of High-Resolution GC/MS
38. Acute Toxicity Prediction in Multiple Species by Leveraging Mechanistic ToxCast Mitochondrial Inhibition Data and Simulation of Oral Bioavailability
39. Dose–Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU
40. A novel approach for concurrent quantitation of glutathione, glutathione disulfide, and 2‐hydroxyethylated glutathione in lungs of mice exposed to ethylene oxide, using liquid chromatography–positive electrospray tandem mass spectrometry
41. Comparative metabolism and pharmacokinetics of diisobutyl ketone and diisobutyl carbinol in male SD rats
42. Chlorpyrifos PBPK/PD model for multiple routes of exposure
43. Quantitation of Diethylene Glycol and Its Metabolites by Gas Chromatography Mass Spectrometry or Ion Chromatography Mass Spectrometry in Rat and Human Biological Samples
44. Dose--Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.
45. Genetic damage, but limited evidence of oxidative stress markers in diethyl maleate-induced glutathione depleted mouse lymphoma L5178Y (TK+/-) cell cultures
46. Toxicokinetic modelling to refine human risk assessment—A case study (aminopyralid)
47. Toxicokinetic Profile of N‐(2‐Aminoethyl)ethanolamine in the Female Wistar Rat and Distribution into the Late Gestation Fetus and Milk
48. In Vitro Age-Dependent Enzymatic Metabolism of Chlorpyrifos and Chlorpyrifos-Oxon in Human Hepatic Microsomes and Chlorpyrifos-Oxon in Plasma
49. In vitrometabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol
50. Dermal Penetration of Ethylene Glycol Through Human Skin In Vitro
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