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1. Longitudinal analysis of chest Q-SPECT/CT in patients with severe COVID-19

Author: Piskac Zivkovic, Nevenka, Mutvar, Andrea, Kuster, Dinka, Lucijanic, Marko, Ljilja Posavec, Anja, Cvetkovic Kucic, Daria, Lalic, Kristina, Vergles, Mirna, Udovicic, Mario, Barsic, Bruno, Rudan, Diana, Luksic, Ivica, Lang, Irene Marthe, and Skoro-Sajer, Nika
Published: 2023
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2. Asymptomatic deep vein thromboses in prolonged hospitalized COVID-19 patients

Author: Lucijanic, Marko, Piskac Zivkovic, Nevenka, Ivic, Marija, Sedinic, Martina, Brkljacic, Boris, Mutvar, Andrea, Atic, Armin, Rudan, Diana, Barsic, Bruno, Luksic, Ivica, Kusec, Rajko, and Ivanac, Gordana
Published: 2021
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3. Usefulness of Presepsin Concentrations for Differentiating Sepsis Severity

Author: Aliu-Bejta, Ajete, primary, Atelj, Anita, additional, Kurshumliu, Mentor, additional, Dreshaj, Shemsedin, additional, and Barsic, Bruno, additional
Published: 2022
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4. Presepsin values as markers of severity of sepsis

Author: Aliu-Bejta, Ajete, Atelj, Anita, Kurshumliu, Mentor, Dreshaj, Shemsedin, and Baršić, Bruno
Published: 2020
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5. Extended Infusion of β-Lactams for Bloodstream Infection in Patients With Liver Cirrhosis : An Observational Multicenter Study

Author: ESGBIS/BICHROME study group, Bartoletti, Michele, Giannella, Maddalena, Lewis, Russell E., Caraceni, Paolo, Tedeschi, Sara, Paul, Mical, Schramm, Christoph, Bruns, Tony, Merli, Manuela, Cobos-Trigueros, Nazaret, Seminari, Elena, Retamar, Pilar, Muñoz, Patricia, Tumbarello, Mario, Burra, Patrizia, Cerenzia, Maria Torrani, Barsic, Bruno, Calbo, Ester, Maraolo, Alberto Enrico, Petrosillo, Nicola, Galan-Ladero, Maria Angeles, D’Offizi, Gianpiero, Zak-Doron, Yael, Rodriguez-Baño, Jesus, Baldassarre, Maurizio, Verucchi, Gabriella, Domenicali, Marco, Bernardi, Mauro, and Viale, Pierluigi
Published: 2019

6. Association between the timing of surgery for complicated, left-sided infective endocarditis and survival

Author: Wang, Andrew, Chu, Vivian H., Athan, Eugene, Delahaye, Francois, Freiberger, Tomas, Lamas, Cristiane, Miro, Jose M., Strahilevitz, Jacob, Tribouilloy, Christophe, Durante-Mangoni, Emanuele, Pericas, Juan M., Fernández-Hidalgo, Nuria, Nacinovich, Francisco, Barsic, Bruno, Giannitsioti, Efthymia, Hurley, John P., Hannan, Margaret M., and Park, Lawrence P.
Published: 2019
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7. Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients

Author: Lucijanic, Marko, primary, Tjesic-Drinkovic, Ida, additional, Piskac Zivkovic, Nevenka, additional, Pastrovic, Frane, additional, Rob, Zrinka, additional, Bacevac, Mersiha, additional, Sedinic Lacko, Martina, additional, Dzambas, Eleonora, additional, Medic, Barbara, additional, Vukoja, Ivan, additional, Busic, Iva, additional, Grgurevic, Ivica, additional, Luksic, Ivica, additional, and Barsic, Bruno, additional
Published: 2023
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8. Proton pump inhibitors use prior to COVID-19 hospitalization is associated with higher C lostridioides difficile infection rate

Author: Lucijanic, Marko, primary, Busic, Nikolina, additional, Stojic, Josip, additional, Barisic-Jaman, Mislav, additional, Zagorec, Nikola, additional, Lazibat, Karla, additional, Pasaric, Antica, additional, Vrkljan Vuk, Anamarija, additional, Durlen, Ivan, additional, Mitrovic, Josko, additional, Luksic, Ivica, additional, and Barsic, Bruno, additional
Published: 2023
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9. Therapeutic hypothermia for adult community-acquired bacterial meningitis—Historical control study

Author: Kutleša, Marko, Lepur, Dragan, and Baršić, Bruno
Published: 2014
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10. Proton pump inhibitors use prior to COVID-19 hospitalization is associated with higher Clostridioides difficileinfection rate

Author: Lucijanic, Marko, Busic, Nikolina, Stojic, Josip, Barisic-Jaman, Mislav, Zagorec, Nikola, Lazibat, Karla, Pasaric, Antica, Vrkljan Vuk, Anamarija, Durlen, Ivan, Mitrovic, Josko, Luksic, Ivica, and Barsic, Bruno
Abstract: ABSTRACTBackgroundThere are uncertainties regarding associations of prior proton pump inhibitor (PPI) use with susceptibility for COVID-19 and risks associated with SARS-CoV-2 infection. We aimed to evaluate the associations of prior PPI use with outcomes in hospitalized patients with COVID-19.Research design and methodsWe have retrospectively evaluated a total of 5959 consecutively hospitalized patients with COVID-19 from a tertiary-level institution in the period 3/2020–6/2021. Associations of prior PPI use with outcomes of in-hospital mortality, mechanical ventilation, intensive care unit stay, venous thromboembolism, arterial thrombosis, major bleeding, bacteremia, and Clostridioides difficileinfection (C. diff.) were evaluated in entire and case-matched cohorts.ResultsAmong 5959 evaluated patients, there were 1967 (33%) PPI users. In an entire cohort, prior PPI use was associated with higher in-hospital mortality and higher occurrence of C. diff. Association of prior PPI use with mortality diminished, whereas association with C. diff. persisted after multivariable adjustments. In a matched cohort, prior PPI use was associated only with higher risk of C. diff. but not other outcomes in line with multivariable analysis.ConclusionsAlthough prior PPI use might not have a significant impact on clinical course and mortality of SARS-CoV-2 infection, it may predispose patients to the development of complications like higher occurrence of C. diff. and thus substantially impact the course of treatment.
Published: 2023
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11. Reply to Wang

Author: Barsic, Bruno
Published: 2013
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12. Reply to Tleyjeh and Baddour

Author: Baršić, Bruno, Wang, Andrew, and Chu, Vivian H.
Published: 2013
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13. Influence of the Timing of Cardiac Surgery on the Outcome of Patients With Infective Endocarditis and Stroke

Author: International Collaboration on Endocarditis—Prospective Cohort Study (ICE-PCS) Investigators, Barsic, Bruno, Dickerman, Stuart, Krajinovic, Vladimir, Pappas, Paul, Altclas, Javier, Carosi, Giampiero, Casabé, José H., Chu, Vivian H., Delahaye, Francois, Edathodu, Jameela, Fortes, Claudio Querido, Olaison, Lars, Pangercic, Ana, Patel, Mukesh, Rudez, Igor, Tamin, Syahidah Syed, Vincelj, Josip, Bayer, Arnold S., and Wang, Andrew
Published: 2013
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14. Remdesivir use in COVID-19 patients might predispose bacteremia, matched case-control analysis

Author: Lucijanic, Marko, Cikara, Tomislav, Bistrovic, Petra, Papic, Ivan, Ortner Hadziabdic, Maja, Busic, Nikolina, Lackovic, Marina, Cesar, Natalia, Koscak, Valentina, Mitrovic, Josko, Barsic, Bruno, and Lucijanic, Tomo
Published: 2022
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15. Short‐term outcomes of patients with chronic liver disease hospitalised with COVID ‐19

Author: Grgurevic, Ivica, primary, Lucijanić, Marko, additional, Pastrovic, Frane, additional, Barisic Jaman, Mislav, additional, Tjesic Drinkovic, Ida, additional, Zelenika, Marko, additional, Milosevic, Marko, additional, Medic, Barbara, additional, Kardum, Dusko, additional, Bokun, Tomislav, additional, Luksic, Ivica, additional, Piskac Zivkovic, Nevenka, additional, Keres, Tatjana, additional, Grabovac, Vlatko, additional, Persec, Jasminka, additional, and Barsic, Bruno, additional
Published: 2022
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16. First cases of human Usutu virus neuroinvasive infection in Croatia, August–September 2013: clinical and laboratory features

Author: Santini, Marija, Vilibic-Cavlek, Tatjana, Barsic, Bruno, Barbic, Ljubo, Savic, Vladimir, Stevanovic, Vladimir, Listes, Eddy, Di Gennaro, Annapia, and Savini, Giovanni
Published: 2015
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17. Vaccination provides protection from respiratory deterioration and death among hospitalized COVID‐19 patients: Differences between vector and mRNA vaccines

Author: Busic, Nikolina, primary, Lucijanic, Tomo, additional, Barsic, Bruno, additional, Luksic, Ivica, additional, Busic, Iva, additional, Kurdija, Goran, additional, Barbic, Ljubo, additional, Kunstek, Sanja, additional, Jelic, Tea, additional, and Lucijanic, Marko, additional
Published: 2022
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18. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association

Author: Baddour, Larry M., Wilson, Walter R., Bayer, Arnold S., Fowler, Vance G., Jr, Tleyjeh, Imad M., Rybak, Michael J., Barsic, Bruno, Lockhart, Peter B., Gewitz, Michael H., Levison, Matthew E., Bolger, Ann F., Steckelberg, James M., Baltimore, Robert S., Fink, Anne M., O‘Gara, Patrick, and Taubert, Kathryn A.
Published: 2015
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19. Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients

Author: Paštrovic, Frane, primary, Lucijanic, Marko, additional, Atic, Armin, additional, Stojic, Josip, additional, Barisic Jaman, Mislav, additional, Tjesic Drinkovic, Ida, additional, Zelenika, Marko, additional, Milosevic, Marko, additional, Medic, Barbara, additional, Loncar, Jelena, additional, Mijic, Maja, additional, Filipec Kanizaj, Tajana, additional, Kralj, Dominik, additional, Lerotic, Ivan, additional, Virovic Jukic, Lucija, additional, Ljubicic, Neven, additional, Luetic, Kresimir, additional, Grgic, Dora, additional, Majerovic, Matea, additional, Ostojic, Rajko, additional, Krznaric, Zeljko, additional, Luksic, Ivica, additional, Piskac Zivkovic, Nevenka, additional, Keres, Tatjana, additional, Grabovac, Vlatko, additional, Persec, Jasminka, additional, Barsic, Bruno, additional, and Grgurevic, Ivica, additional
Published: 2021
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20. The relationship between the initiation of antimicrobial therapy and the incidence of stroke in infective endocarditis: An analysis from the ICE Prospective Cohort Study (ICE-PCS)

Author: Dickerman, Stuart A., Abrutyn, Elias, Barsic, Bruno, Bouza, Emilio, Cecchi, Enrico, Moreno, Asuncion, Doco-Lecompte, Thanh, Eisen, Damon P., Fortes, Claudio Q., Fowler, Vance G., Jr., Lerakis, Stamatios, Miro, Jose M., Pappas, Paul, Peterson, Gail E., Rubinstein, Ethan, Sexton, Daniel J., Suter, Fredy, Tornos, Pilar, Verhagen, Dominique W., and Cabell, Christopher H.
Published: 2007
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21. Infective Endocarditis in Patients on Chronic Hemodialysis

Author: Pericàs, Juan M., primary, Llopis, Jaume, additional, Jiménez-Exposito, Maria Jesús, additional, Kourany, Wissam M., additional, Almirante, Benito, additional, Carosi, Giampiero, additional, Durante-Mangoni, Emanuele, additional, Fortes, Claudio Querido, additional, Giannitsioti, Efthymia, additional, Lerakis, Stamatios, additional, Montagna-Mella, Rodrigo, additional, Ambrosioni, Juan, additional, Tan, Ru-San, additional, Mestres, Carlos A., additional, Wray, Dannah, additional, Pachirat, Orathai, additional, Moreno, Asuncion, additional, Chu, Vivian H., additional, de Lazzari, Elisa, additional, Fowler, Vance G., additional, Miró, Jose M., additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Oses, Pablo Fernandez, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Altclas, Javier, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Tan, Ren, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, Passos de Brito, Ana Cláudia, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Siciliano, Rinaldo Focaccia, additional, Varejao Strabelli, Tania Mara, additional, Campos Vieira, Marcelo Luiz, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Cereceda, M., additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Gonzalez, Javier, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, CHU Catherine, additional, Doco-Lecompte, Thanh, additional, Selton-Suty, Christine, additional, Casalta, Jean-Paul, additional, Fournier, Pierre-Edouard, additional, Habib, Gilbert, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Sophia Athanasia, Carl Neuerburg, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Skoutelis, Athanasios, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Wanounou, Maor, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Iossa, Domenico, additional, Orlando, Serena, additional, Ursi, Maria Paola, additional, Pafundi, Pia Clara, additional, D’Amico, Fabiana, additional, Bernardo, Mariano, additional, Cuccurullo, Susanna, additional, Dialetto, Giovanni, additional, Covino, Franco Enrico, additional, Manduca, Sabrina, additional, Della Corte, Alessandro, additional, De Feo, Marisa, additional, Tripodi, Marie Françoise, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif-Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Edathodu, Jameela, additional, Halim, Magid, additional, Liew, Yee-Yun, additional, Lejko-Zupanc, Tatjana, additional, Logar, Mateja, additional, Mueller-Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manel, additional, Azqueta, Manuel, additional, Brunet, Merce, additional, Castro, Pedro, additional, De Lazzari, Elisa, additional, Falces, Carlos, additional, Fuster, David, additional, Fita, Guillermina, additional, Garcia- de- la- Maria, Cristina, additional, Garcia-Gonzalez, Javier, additional, Gatell, Jose M., additional, Marco, Francesc, additional, Miró, José M., additional, Ortiz, José, additional, Ninot, Salvador, additional, Paré, J. Carlos, additional, Pericas, Juan M., additional, Quintana, Eduard, additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Tellez, Adrian, additional, Tolosana, José M., additional, Vidal, Barbara, additional, Vila, Jordi, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez-Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez-Créixems, Marta, additional, Solis, Jorge, additional, Fernandez-Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg-Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Wang, Andrew, additional, Woods, Christopher W., additional, Cantey, Robert, additional, Steed, Lisa, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara-Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Peterson, Gail, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, and Cabell, Christopher H., additional
Published: 2021
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22. Staphylococcus aureus endocarditis: A consequence of medical progress

Author: Fowler, Vance G., Jr., Cabell, Christopher H., Corey, G. Ralph, Wray, Dannah, Meer, Jan T.M. van der, Miro, Jose M., Hoen, Bruno, Barsic, Bruno, Abrutyn, Elias, Rubinstein, Ethan, Pappas, Paul A., Spelman, Denis, Bradley, Suzanne F., Anstrom, Kevin J., Fortes, Claudio Q., Anguera, Ignasi, Athan, Eugene, Jones, Philip, Elliott, Tom S.J., Levine, Donald P., and Bayer, Arnold S.
Subjects: Infection control -- Methods, Endocarditis -- Risk factors, Staphylococcal infections -- Risk factors
Abstract: Regional variation in patients with Staphylococcus aureus infective endocarditis (IE) is evaluated and the characteristics of IE caused by Staphylococcus aureus are documented. The findings suggest the need to reduce the number of health care associated infections through improved compliance with infection control procedures and the need for new interventions and preventive strategies.
Published: 2005

23. Chlamydia pneumoniae infection as a trigger for a Cogan's syndrome

Author: Lepur, Dragan, Vranjican, Zoran, Himbele, Josip, Klinar, Igor, and Baršić, Bruno
Published: 2006
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24. Liver involvement during influenza infection: perspective on the 2009 influenza pandemic

Author: Papic, Neven, Pangercic, Ana, Vargovic, Martina, Barsic, Bruno, Vince, Adriana, and Kuzman, Ilija
Published: 2012
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25. SARS-CoV-2 Seroprevalence in a Cohort of Asymptomatic RT-PCR Negative Croatian First League Football Players

Author: Vince, Adriana, primary, Zadro, Renata, additional, Sostar, Zvonimir, additional, Ljubin Sternak, Suncanica, additional, Vranes, Jasmina, additional, Skaro, Vedrana, additional, Projic, Petar, additional, Molnar, Vilim, additional, Matisic, Vid, additional, Barsic, Bruno, additional, Lauc, Gordan, additional, Lovric-Makaric, Zvjezdana, additional, Bahtijarevic, Zoran, additional, Vlahovic, Tomislav, additional, Sikic, Sandra, additional, Polasek, Ozren, additional, and Primorac, Dragan, additional
Published: 2021
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26. Increased expression of CXCR3 and CCR5 on memory CD4 + T-cells migrating into the cerebrospinal fluid of patients with neuroborreliosis: The role of CXCL10 and CXCL11

Author: Židovec Lepej, Snježana, Đaković Rode, Oktavija, Jeren, Tatjana, Vince, Adriana, Remenar, Anica, and Baršić, Bruno
Published: 2005
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27. Current Features of Infective Endocarditis in Elderly Patients: Results of the International Collaboration on Endocarditis Prospective Cohort Study

Author: Durante-Mangoni, Emanuele, Bradley, Suzanne, Selton-Suty, Christine, Tripodi, Marie-Françoise, Barsic, Bruno, Bouza, Emilio, Cabell, Christopher H., de Oliveira Ramos, Auristela Isabel, Fowler, Vance, Jr, Hoen, Bruno, Koneçny, Pam, Moreno, Asuncion, Murdoch, David, Pappas, Paul, Sexton, Daniel J., Spelman, Denis, Tattevin, Pierre, Miró, José M., van der Meer, Jan T. M., and Utili, Riccardo
Published: 2008

28. Antibiotic policies in Central Eastern Europe

Author: Cizman, Milan, Beovic, Bojana, Krcmery, Vladimir, Barsic, Bruno, Tamm, Eda, Ludwig, Endre, Pelemis, Mojimir, Karovski, Kliment, Grzesiowski, Pavel, Gardovska, Dace, Volokha, Alla, Keuleyan, Emma, Stratchounski, Leonid, Dumitru, Carstina, Titov, Leonid P., Usonis, Vytantas, and Dvorák, Peter
Published: 2004
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29. Corrigendum to “association between the timing of surgery for complicated, left-sided infective endocarditis and survival”, American Heart Journal 2019, volume 210, April 2019, pages 108–116

Author: Wang, Andrew, primary, Chu, Vivian H., additional, Athan, Eugene, additional, Delahaye, Francois, additional, Freiberger, Tomas, additional, Lamas, Cristiane, additional, Miro, Jose M., additional, Strahilevitz, Jacob, additional, Tribouilloy, Christophe, additional, Durante-Mangoni, Emanuele, additional, Pericas, Juan M., additional, Fernández-Hidalgo, Nuria, additional, Nacinovich, Francisco, additional, Barsic, Bruno, additional, Giannitsioti, Efthymia, additional, Hurley, John P., additional, Hannan, Margaret M., additional, and Park, Lawrence P., additional
Published: 2019
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30. Extended Infusion of beta-Lactams for Bloodstream Infection in Patients With Liver Cirrhosis: An Observational Multicenter Study

Author: Bartoletti, Michele, Giannella, Maddalena, Lewis, Russell E., Caraceni, Paolo, Tedeschi, Sara, Paul, Mical, Schramm, Christoph, Bruns, Tony, Merli, Manuela, Cobos-Trigueros, Nazaret, Seminari, Elena, Retamar, Pilar, Munoz, Patricia, Tumbarello, Mario, Burra, Patrizia, Cerenzia, Maria Torrani, Barsic, Bruno, Calbo, Ester, Maraolo, Alberto Enrico, Petrosillo, Nicola, Galan-Ladero, Maria Angeles, D'Offizi, Gianpiero, Zak-Doron, Yael, Rodriguez-Bano, Jesus, Baldassarre, Maurizio, Verucchi, Gabriella, Domenicali, Marco, Bernardi, Mauro, Viale, Pierluigi, Campoli, Caterina, Pascale, Renato, Stallmach, Andreas, Venditti, Mario, Lucidi, Cristina, Ludovisi, Serena, de Cueto, Marina, Maria Dolores, Navarro, Cortes Eduardo, Lopez, Bouza, Emilo, Valerio, Maricela, Eworo, Alia, Losito, Raffaella, Senzolo, Marco, Nadal, Elena, Ottobrelli, Antonio, Varguvic, Martina, Badia, Cristina, Guglielmo, Borgia, Gentile, Ivan, Buonomo, Antonio Riccardo, Boumis, Evangelo, Beteta-Lopez, Alicia, Rianda, Alessia, Taliani, Gloria, Grieco, Stefania, Bartoletti, Michele, Giannella, Maddalena, Lewis, Russell E., Caraceni, Paolo, Tedeschi, Sara, Paul, Mical, Schramm, Christoph, Bruns, Tony, Merli, Manuela, Cobos-Trigueros, Nazaret, Seminari, Elena, Retamar, Pilar, Munoz, Patricia, Tumbarello, Mario, Burra, Patrizia, Cerenzia, Maria Torrani, Barsic, Bruno, Calbo, Ester, Maraolo, Alberto Enrico, Petrosillo, Nicola, Galan-Ladero, Maria Angeles, D'Offizi, Gianpiero, Zak-Doron, Yael, Rodriguez-Bano, Jesus, Baldassarre, Maurizio, Verucchi, Gabriella, Domenicali, Marco, Bernardi, Mauro, Viale, Pierluigi, Campoli, Caterina, Pascale, Renato, Stallmach, Andreas, Venditti, Mario, Lucidi, Cristina, Ludovisi, Serena, de Cueto, Marina, Maria Dolores, Navarro, Cortes Eduardo, Lopez, Bouza, Emilo, Valerio, Maricela, Eworo, Alia, Losito, Raffaella, Senzolo, Marco, Nadal, Elena, Ottobrelli, Antonio, Varguvic, Martina, Badia, Cristina, Guglielmo, Borgia, Gentile, Ivan, Buonomo, Antonio Riccardo, Boumis, Evangelo, Beteta-Lopez, Alicia, Rianda, Alessia, Taliani, Gloria, and Grieco, Stefania
Abstract: Background. We analyzed the impact of continuous/extended infusion (C/EI) vs intermittent infusion of piperacillin-tazobactam (TZP) and carbapenems on 30-day mortality of patients with liver cirrhosis and bloodstream infection (BSI). Methods. The BICRHOME study was a prospective, multicenter study that enrolled 312 cirrhotic patients with BSI. In this secondary analysis, we selected patients receiving TZP or carbapenems as adequate empirical treatment. The 30-day mortality of patients receiving C/EI or intermittent infusion of TZP or carbapenems was assessed with Kaplan-Meier curves, Cox-regression model, and estimation of the average treatment effect (ATE) using propensity score matching. Results. Overall, 119 patients received TZP or carbapenems as empirical treatment. Patients who received C/EI had a significantly lower mortality rate (16% vs 36%, P = .047). In a Cox-regression model, the administration of C/EI was associated with a significantly lower mortality (hazard ratio [HR], 0.41; 95% confidence interval [CI], 0.11-0.936; P = .04) when adjusted for severity of illness and an ATE of 25.6% reduction in 30-day mortality risk (95% CI, 18.9-32.3; P < .0001) estimated with propensity score matching. A significant reduction in 30-day mortality was also observed in the subgroups of patients with sepsis (HR, 0.21; 95% CI, 0.06-0.74), acute-on-chronic liver failure (HR, 0.29; 95% CI, 0.03-0.99), and a model for end-stage liver disease score >= 25 (HR, 0.26; 95% CI, 0.08-0.92). At competing risk analysis, C/EI of beta-lactams was associated with significantly higher rates of hospital discharge (subdistribution hazard [95% CI], 1.62 [1.06-2.47]). Conclusions. C/EI of beta-lactams in cirrhotic patients with BSI may improve outcomes and facilitate earlier discharge.
Published: 2019

31. Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Author: Erdem, Hakan, Ozturk-Engin, Derya, Cag, Yasemin, Senbayrak, Seniha, Inan, Asuman, Kazak, Esra, Savasci, Umit, Elaldi, Nazif, Vahaboglu, Haluk, Hasbun, Rodrigo, Nechifor, Mihai, Tireli, Hulya, Kilicoglu, Gamze, Defres, Sylviane, Gulsun, Serda, Ceran, Nurgul, Crisan, Alexandru, Johansen, Isik Somuncu, Namiduru, Mustafa, Dayan, Saim, Kayabas, Uner, Parlak, Emine, Khalifa, Ahmad, Kursun, Ebru, Sipahi, Oguz Resat, Yemisen, Mucahit, Akbulut, Ayhan, Bitirgen, Mehmet, Popovic, Natasa, Kandemir, Bahar, Luca, Catalina, Parlak, Mehmet, Stahl, Jean Paul, Pehlivanoglu, Filiz, Simeon, Soline, Ulu-Kilic, Aysegul, Yasar, Kadriye, Yilmaz, Gulden, Yilmaz, Emel, Beovic, Bojana, Catroux, Melanie, Lakatos, Botond, Sunbul, Mustafa, Oncul, Oral, Alabay, Selma, Sahin-Horasan, Elif, Kose, Sukran, Shehata, Ghaydaa, Andre, Katell, Dragovac, Gorana, Gul, Hanefi Cem, Karakas, Ahmet, Chadapaud, Stéphane, Hansmann, Yves, Harxhi, Arjan, Kirova, Valerija, Masse-Chabredier, Isabelle, Oncu, Serkan, Sener, Alper, Tekin, Recep, Deveci, Ozcan, Ozkaya, Hacer Deniz, Karabay, Oguz, Agalar, Canan, Gencer, Serap, Karahocagil, Mustafa Kasim, Karsen, Hasan, Kaya, Selcuk, Pekok, Abdullah Umut, Celen, Mustafa Kemal, Deniz, Secil, Ulug, Mehmet, Demirdal, Tuna, Guven, Tumer, Bolukcu, Sibel, Avci, Meltem, Nayman-Alpat, Saygin, Yaşar, Kadriye, Pehlivanoʇlu, Filiz, Ates-Guler, Selma, Mutlu-Yilmaz, Esmeray, Tosun, Selma, Sirmatel, Fatma, Batirel, Ayşe, Öztoprak, Nefise, Kadanali, Ayten, Turgut, Huseyin, Baran, Ali Irfan, Karaahmetoglu, Gokhan, Sunnetcioglu, Mahmut, Haykir-Solay, Asli, Denk, Affan, Ayaz, Celal, Gorenek, Levent, Larsen, Lykke, Poljak, Mario, Barsic, Bruno, Argemi, Xavier, Sørensen, Signe Maj, Bohr, Anne Lisbeth, Tattevin, Pierre, Gunst, Jesper Damsgaard, Baštáková, Lenka, Jereb, Matjaž, Chehri, Mahtab, Beraud, Guillaume, Del Vecchio, Rosa Fontana, Maresca, Mauro, Yilmaz, Hava, Sharif-Yakan, Ahmad, Kanj, Souha Shararah, Korkmaz, Fatime, Komur, Suheyla, Coskuner, Seher Ayten, Ince, Nevin, Akkoyunlu, Yasemin, Halac, Gulistan, Nemli, Salih Atakan, Ak, Oznur, Gunduz, Alper, Gozel, Mustafa G., Hatipoglu, Mustafa, Cicek-Senturk, Gonul, Akcam, Fusun Z., Inkaya, Ahmet C., Sagmak-Tartar, Ayşe, Ersoy, Yasemin, Tuncer-Ertem, Gunay, Balkan, Ilker I., Cetin, Birsen, Ersoz, Gulden, Ozgunes, Nail, Yesilkaya, Aysegul, Erturk, Ayse, Gundes, Sibel, Turhan, Vedat, Yalci, Aysun, Aydin, Emsal, Diktas, Husrev, Ulcay, Asim, Seyman, Derya, Leblebicioglu, Hakan, [Erdem, Hakan -- Savasci, Umit] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Ozturk-Engin, Derya -- Senbayrak, Seniha -- Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Cag, Yasemin] Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kazak, Esra] Uludag Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Vahaboglu, Haluk] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Hasbun, Rodrigo] UT Hlth McGovern Med Sch, Dept Infect Dis, Houston, TX 77030 USA, Kart Yasar, Kadriye -- 0000-0003-2963-4894, Larsen, Lykke -- 0000-0002-4113-4182, VAHABOGLU, Haluk -- 0000-0001-8217-1767, Mikrobiyoloji, OMÜ, Çukurova Üniversitesi, Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Kazak, Esra, AAG-8459-2021, and Ege Üniversitesi
Subjects: 0301 basic medicine, Male, Leukocytosis, 0302 clinical medicine, CSF, Encephalitis, Leukocyte, Meningitis, Pleocytosis, Neurosyphilis, Diagnosis, Pathology, Medicine, 030212 general & internal medicine, Brucella meningitis, Middle aged, biology, Meningitis, Pneumococcal, General Medicine, Middle Aged, Central nervous system infection, Tıp, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, medicine.anatomical_structure, Cerebrospinal fluid, Bacterial Meningitides, Cerebrospinal Fluid, Infectious diseases, Protein cerebrospinal fluid level, Pneumococcal, Female, InformationSystems_MISCELLANEOUS, Human, Microbiology (medical), 030106 microbiology, Central nervous system, Brucella, Outcomes, Cerebrospinal fluid pleocytosis, Tuberculous meningitis, Article, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Humans, lcsh:RC109-216, Leukocytosis/cerebrospinal fluid, Herpes simplex encephalitis, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Herpetic meningoencephalitis, Central Nervous System Infections/cerebrospinal fluid, Pneumococcal meningitis, Tuberculosis, meningeal, medicine.disease, biology.organism_classification, Meningitis, Pneumococcal/cerebrospinal fluid, ComputingMethodologies_PATTERNRECOGNITION, Tuberculosis, Meningeal/cerebrospinal fluid, Clinical feature, Immunology, business, Central nervous system infections
Abstract: WOS: 000417628500023, PubMed ID: 29081366, Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases., Grant-A-Starr Foundation, Grant-A-Starr Foundation.
Published: 2017
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32. Relationship between age and intensive care unit-acquired bloodstream infections in infectious disease patients in Croatia

Author: Balen Topic, Mirjana, primary, Santini, Marija, additional, and Barsic, Bruno, additional
Published: 2018
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33. Association Between Cardiac Surgery and Mortality Among Patients With Infective Endocarditis Complicated by Sepsis and Septic Shock

Author: Krajinovic, Vladimir, primary, Ivancic, Stipe, additional, Gezman, Petar, additional, and Barsic, Bruno, additional
Published: 2018
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34. A prospective multicentre study of the epidemiology and outcomes of bloodstream infection in cirrhotic patients

Author: Bartoletti, Michele, Giannella, Maddalena, Lewis, R., Caraceni, Paolo, Tedeschi, Sara, Paul, Mical, Schramm, Christoph, Bruns, Tony, Merli, Manuela, Cobos-Trigueros, Nazaret, Seminari, Elena María, Retamar Gentil, Pilar, Muñoz García, Patricia, Tumbarello, Mario, Burra, Patrizia, Torrani Cerenzia, M., Barsic, Bruno, Calbo, Esther, Maraolo, Alberto E., Petrosillo, N., Galán-Ladero, M. A., D'Offizi, Gianpiero, Bar Sinai, N., Rodríguez-Baño, Jesús, Verucchi, Gabriella, Bernardi, Mauro, Viale, Pierluigi, Bartoletti, Michele, Giannella, Maddalena, Lewis, R., Caraceni, Paolo, Tedeschi, Sara, Paul, Mical, Schramm, Christoph, Bruns, Tony, Merli, Manuela, Cobos-Trigueros, Nazaret, Seminari, Elena María, Retamar Gentil, Pilar, Muñoz García, Patricia, Tumbarello, Mario, Burra, Patrizia, Torrani Cerenzia, M., Barsic, Bruno, Calbo, Esther, Maraolo, Alberto E., Petrosillo, N., Galán-Ladero, M. A., D'Offizi, Gianpiero, Bar Sinai, N., Rodríguez-Baño, Jesús, Verucchi, Gabriella, Bernardi, Mauro, and Viale, Pierluigi
Abstract: [Objectives] To describe the current epidemiology of bloodstream infection (BSI) in patients with cirrhosis; and to analyse predictors of 30-day mortality and risk factors for antibiotic resistance., [Methods] Cirrhotic patients developing a BSI episode were prospectively included at 19 centres in five countries from September 2014 to December 2015. The discrimination of mortality risk scores for 30-day mortality were compared by area under the receiver operator risk and Cox regression models. Risk factors for multidrug-resistant organisms (MDRO) were assessed with a logistic regression model., [Results] We enrolled 312 patients. Gram-negative bacteria, Gram-positive bacteria and Candida spp. were the cause of BSI episodes in 53%, 47% and 7% of cases, respectively. The 30-day mortality rate was 25% and was best predicted by the Sequential Organ Failure Assessment (SOFA) and Chronic Liver Failure–SOFA (CLIF-SOFA) score. In a Cox regression model, delayed (>24 hours) antibiotic treatment (hazard ratio (HR) 7.58; 95% confidence interval (CI) 3.29–18.67; p < 0.001), inadequate empirical therapy (HR 3.14; 95% CI 1.93–5.12; p < 0.001) and CLIF-SOFA score (HR 1.35; 95% CI 1.28–1.43; p < 0.001) were independently associated with 30-day mortality. Independent risk factors for MDRO (31% of BSIs) were previous antimicrobial exposure (odds ratio (OR) 2.91; 95% CI 1.73–4.88; p < 0.001) and previous invasive procedures (OR 2.51; 95% CI 1.48–4.24; p 0.001), whereas spontaneous bacterial peritonitis as BSI source was associated with a lower odds of MDRO (OR 0.30; 95% CI 0.12–0.73; p 0.008)., [Conclusions] MDRO account for nearly one-third of BSI in cirrhotic patients, often resulting in delayed or inadequate empirical antimicrobial therapy and increased mortality rates. Our data suggest that improved prevention and treatment strategies for MDRO are urgently needed in the liver cirrhosis patients.
Published: 2018

35. Quadruple-valve infective endocarditis caused by Abiotrophia defectiva

Author: Planinc, Mislav, primary, Kutlesa, Marko, additional, Barsic, Bruno, additional, and Rudez, Igor, additional
Published: 2017
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36. P1621: INCIDENCE, RISK FACTORS AND MORTALITY ASSOCIATED WITH MAJOR BLEEDING EVENTS IN HOSPITALIZED COVID‐19 PATIENTS, TERTIARY CENTER EXPERIENCE.

Author: Lucijanic, Marko, Tjesic‐Drinkovic, Ida, Zivkovic, Nevenka Piskac, Pastrovic, Frane, Rob, Zrinka, Bacevac, Mersiha, Lacko, Martina Sedinić, Dzambas, Eleonora, Medic, Barbara, Vukoja, Ivan, Busic, Iva, Grgurevic, Ivica, Luksic, Ivica, and Barsic, Bruno
Published: 2023
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37. Results of a multinational study suggests rapid diagnosis and early onset of antiviral treatment in herpetic meningoencephalitis

Author: Erdem, Hakan, Cag, Yasemin, Ozturk-Engin, Derya, Defres, Sylviane, Kaya, Selcuk, Larsen, Lykke, Poljak, Mario, Barsic, Bruno, Argemi, Xavier, Sørensen, Signe Maj, Bohr, Anne Lisbeth, Tattevin, Pierre, Gunst, Jesper Damsgaard, Baštáková, Lenka, Jereb, Matjaž, Somuncu Johansen, Isik, Karabay, Oguz, Pekok, Abdullah Umut, Sipahi, Oguz Resat, Chehri, Mahtab, Beraud, Guillaume, Shehata, Ghaydaa, Fontana del Vecchio, Rosa, Maresca, Mauro, Karsen, Hasan, Sengoz, Gonul, Sunbul, Mustafa, Yilmaz, Gulden, Yilmaz, Hava, Sharif-Yakan, Ahmad, Kanj, Souha, Parlak, Emine, Pehlivanoglu, Filiz, Korkmaz, Fatime, Komur, Suheyla, Kose, Sukran, Ulug, Mehmet, Bolukcu, Sibel, Coskuner, Seher Ayten, Ince, Nevin, Akkoyunlu, Yasemin, Halac, Gulistan, Sahin-Horasan, Elif, Tireli, Hulya, Kilicoglu, Gamze, Al-Mahdawi, Akram, Nemli, Salih Atakan, Inan, Asuman, Senbayrak, Seniha, Stahl, Jean Paul, Vahaboglu, Haluk, Institute of Microbiology and Immunology, Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Fonction, structure et inactivation d'ARN bactériens, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institute of Microbiology and Immunology - Inštitut za mikrobiologijo in imunologijo [Ljubljana, Slovenia], and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Abstract: International audience; Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
Published: 2015
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38. Extended Infusion of β-Lactams for Bloodstream Infection in Patients With Liver Cirrhosis: An Observational Multicenter Study.

Author: Bartoletti, Michele, Giannella, Maddalena, Lewis, Russell E, Caraceni, Paolo, Tedeschi, Sara, Paul, Mical, Schramm, Christoph, Bruns, Tony, Merli, Manuela, Cobos-Trigueros, Nazaret, Seminari, Elena, Retamar, Pilar, Muñoz, Patricia, Tumbarello, Mario, Burra, Patrizia, Cerenzia, Maria Torrani, Barsic, Bruno, Calbo, Ester, Maraolo, Alberto Enrico, and Petrosillo, Nicola
Subjects: MORTALITY risk factors, BACTEREMIA, COMBINATION drug therapy, CONFIDENCE intervals, INFUSION therapy equipment, CIRRHOSIS of the liver, LIVER diseases, LIVER failure, LONGITUDINAL method, PENICILLIN, MEDICAL cooperation, SCIENTIFIC observation, PROBABILITY theory, RESEARCH, RISK assessment, SEPSIS, SECONDARY analysis, DISCHARGE planning, TREATMENT effectiveness, PROPORTIONAL hazards models, SEVERITY of illness index, CARBAPENEMS, AMPICILLIN, KAPLAN-Meier estimator, ODDS ratio, DISEASE complications
Abstract: Background We analyzed the impact of continuous/extended infusion (C/EI) vs intermittent infusion of piperacillin-tazobactam (TZP) and carbapenems on 30-day mortality of patients with liver cirrhosis and bloodstream infection (BSI). Methods The BICRHOME study was a prospective, multicenter study that enrolled 312 cirrhotic patients with BSI. In this secondary analysis, we selected patients receiving TZP or carbapenems as adequate empirical treatment. The 30-day mortality of patients receiving C/EI or intermittent infusion of TZP or carbapenems was assessed with Kaplan-Meier curves, Cox-regression model, and estimation of the average treatment effect (ATE) using propensity score matching. Results Overall, 119 patients received TZP or carbapenems as empirical treatment. Patients who received C/EI had a significantly lower mortality rate (16% vs 36%, P =.047). In a Cox-regression model, the administration of C/EI was associated with a significantly lower mortality (hazard ratio [HR], 0.41; 95% confidence interval [CI], 0.11–0.936; P =.04) when adjusted for severity of illness and an ATE of 25.6% reduction in 30-day mortality risk (95% CI, 18.9–32.3; P <.0001) estimated with propensity score matching. A significant reduction in 30-day mortality was also observed in the subgroups of patients with sepsis (HR, 0.21; 95% CI, 0.06–0.74), acute-on-chronic liver failure (HR, 0.29; 95% CI, 0.03–0.99), and a model for end-stage liver disease score ≥25 (HR, 0.26; 95% CI, 0.08–0.92). At competing risk analysis, C/EI of beta-lactams was associated with significantly higher rates of hospital discharge (subdistribution hazard [95% CI], 1.62 [1.06–2.47]). Conclusions C/EI of beta-lactams in cirrhotic patients with BSI may improve outcomes and facilitate earlier discharge. [ABSTRACT FROM AUTHOR]
Published: 2019
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39. The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis.

Author: Fosbøl, Emil L, Park, Lawrence P, Chu, Vivian H, Athan, Eugene, Delahaye, Francois, Freiberger, Tomas, Lamas, Cristiane, Miro, Jose M, Strahilevitz, Jacob, Tribouilloy, Christophe, Durante-Mangoni, Emanuele, Pericas, Juan M, Fernández-Hidalgo, Nuria, Nacinovich, Francisco, Rizk, Hussein, Barsic, Bruno, Giannitsioti, Efthymia, Hurley, John P, Hannan, Margaret M, and Wang, Andrew
Abstract: Aims In left-sided infective endocarditis (IE), a large vegetation >10 mm is associated with higher mortality, yet it is unknown whether surgery during the acute phase opposed to medical therapy is associated with improved survival. We assessed the association between surgery and 6-month mortality as related to vegetation size. Methods and results Patients with definite, left-sided IE (2008–2012) from The International Collaboration on Endocarditis prospective, multinational registry were included. We compared clinical characteristics and 6-month mortality (by Cox regression with inverse propensity of treatment weighting) between patients with vegetation size ≤10 mm vs. >10 mm in maximum length by surgical treatment strategy. A total of 1006 patients with left sided IE were included; 422 with a vegetation size ≤10 mm (median age 66.0 years, 33% women) and 584 (median age 58.4 years, 34% women) patients with a large vegetation >10 mm. Operative risk by STS-IE score was similar between groups. Embolic events occurred in 28.4% vs. 44.3% (P < 0.001), respectively. Patients with a vegetation >10 mm was associated with higher 6-month mortality (25.1% vs. 19.4% for small vegetation, P = 0.035). However, after propensity adjustment, the association with higher mortality persisted only in patients with a large vegetation >10 mm vs. ≤10 mm: hazard ratio (HR) 1.55 (1.27–1.90); but only in patients with large vegetation managed medically [HR 1.86 (1.48–2.34)] rather than surgically [HR 1.01 (0.69–1.49)]. Conclusion Left-sided IE with vegetation size >10 mm was associated with an increased mortality at 6 months in this observational study but was dependent on treatment strategy. For patients with large vegetation undergoing surgical treatment, survival was similar to patients with smaller vegetation size. [ABSTRACT FROM AUTHOR]
Published: 2019
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40. First molecular analysis of West Nile virus during the 2013 outbreak in Croatia

Author: Kurolt, Ivan C., Krajinović, Vladimir, Topić, Antea, Kuzman, Ilija, Baršić, Bruno, and Markotić, Alemka
Published: 2014
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41. Corrigendum to “association between the timing of surgery for complicated, left-sided infective endocarditis and survival”, American HeartJournal 2019, volume 210, April 2019, pages 108–116

Author: Wang, Andrew, Chu, Vivian H., Athan, Eugene, Delahaye, Francois, Freiberger, Tomas, Lamas, Cristiane, Miro, Jose M., Strahilevitz, Jacob, Tribouilloy, Christophe, Durante-Mangoni, Emanuele, Pericas, Juan M., Fernández-Hidalgo, Nuria, Nacinovich, Francisco, Barsic, Bruno, Giannitsioti, Efthymia, Hurley, John P., Hannan, Margaret M., and Park, Lawrence P.
Published: 2019
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42. Demographic, clinical and laboratory characteristics of patients with West Nile virus neuroinvasive disease in Croatia, 2012-2013

Author: Santini, Marija, Vilibic-Cavlek, Tatjana, Barsic, Bruno, Pandak, Nenad, Peric, Ljiljana, Kokic, Iva, Barbic, Ljubo, Stevanovic, Vladimir, Listes, Eddy, Di Gennaro, Annapia, Savini, Giovanni, and ESCMID
Subjects: West Nile virus, neuroinvasive disease, Croatia
Abstract: Objective: In the last few years, West Nile virus (WNV) has re-emerged in many European countries. In Croatia, cases of WNV infection were detected during the two consecutive transmission seasons (2012-2013). We analyzed demographic, clinical and laboratory characteristics of Croatian patients with WNV neuroinvasive disease. Methods: WNV IgM/IgG and IgG avidity testing on serum samples were performed using a commercial ELISA (Euroimmun, Lübeck, Germany) and confirmed by virus neutralization test. For 19 patients, cerebrospinal fluid (CSF) samples were tested for WNV RNA by real- time RT-PCR. All patients met clinical and laboratory criteria for confirmed cases according to the EU case definition for WNV infection. Results: WNV neuroinvasive infection was confirmed in 27 patients. There were 20 (74.1%) males and 7 (25.9%) females (male to female ratio 2.9:1). The median age was 63 (range 28-79) years. The majority of patients (20/74.1%) were older than 50 years. Twenty-one (77.8%) patients presented with meningoencephalitis, 4 (14.8%) with meningitis, while in two (7.4%) patients disease started with meningitis followed by acute flaccid paralysis. Most of them (18/66.7%) reported underlying diseases, the most common being hypertension (14/51.8%) and diabetes (7/25.9%). Two patients (7.4%) underwent organ transplantation. The main clinical symptoms and signs include fever (27/100%), headache (13/48.1%), nuchal rigidity (10/37.0%), tremor (9/33.3%), vomiting (9/33.3%), nausea (8/29.6%) and fatigue (8/29.6%). Altered level of consciousness and disorientation were detected in 7/25.9% and 6/22.2% patients, respectively. Two (7.4%) patients were mechanically ventilated due to respiratory failure. Total leukocyte count in peripheral blood was elevated in 8/29.6% patients. CSF examination showed pleocytosis with leukocyte counts ranging from 10- 3580 cells/mm3 (mononuclear cell predominance in 19/70.4% patients), elevated protein levels (0.49-2.5 g/L) and normal glucose levels. Abnormal EEG findings (irregular and/or diffuse slowing) were obtained in 22/24 (91.6%) patients. Of 22 patients with either CT or MRI scans, 14 (63.6%) had normal findings, while in 8 (36.4%) nonacute abnormalities were found (brain atrophy, chronic vascular lesions). Serology results showed WNV IgM antibodies in all patients (ratio 1.51-4.14) and WNV IgG antibodies in 26 patients (28-170 RU/ml). WNV IgG avidity was low in 24/92.3% (11%-37%) and borderline in 2/7.7% patients (40% and 60%, respectively). In 14 paired serum samples, a negative-to-positive seroconversion of IgG antibodies was documented. Titer of neutralizing antibodies was 5-80. All tested CSF samples were negative for WNV RNA. The median hospitalization time was 17 (range 11-74) days. A complete recovery was seen in 22/81.5% patients, while 5/18.5% patients presented neurologic sequelae (muscle weakness). Conclusion: The majority of the Croatian patients with confirmed WNV neuroinvasive disease were older than 50 years (74.1%) and reported several comorbidities (66.7%). The main clinical presentation was meningoencephalitis (77.8%). Persistent neurologic sequelae were detected in 18.5% patients.
Published: 2015

43. Validated Risk Score for Predicting 6‐Month Mortality in Infective Endocarditis

Author: Park, Lawrence P., primary, Chu, Vivian H., additional, Peterson, Gail, additional, Skoutelis, Athanasios, additional, Lejko‐Zupa, Tatjana, additional, Bouza, Emilio, additional, Tattevin, Pierre, additional, Habib, Gilbert, additional, Tan, Ren, additional, Gonzalez, Javier, additional, Altclas, Javier, additional, Edathodu, Jameela, additional, Fortes, Claudio Querido, additional, Siciliano, Rinaldo Focaccia, additional, Pachirat, Orathai, additional, Kanj, Souha, additional, Wang, Andrew, additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Fernandez Oses, Pablo, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, de Brito, Ana Cláudia Passos, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Strabelli, Tania Mara Varejao, additional, Vieira, Marcelo Luiz Campos, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, Catherine, additional, Doco‐Lecompte, Thanh, additional, Selton‐Suty, Christine, additional, Casalta, Jean‐Paul, additional, Fournier, Pierre‐Edouard, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Athanasia, Sophia, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Giannitsioti, Efthymia, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Cahan, Amos, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Durante‐Mangoni, Emanuele, additional, Mattucci, Irene, additional, Pinto, Daniela, additional, Agrusta, Federica, additional, Senese, Alessandra, additional, Ragone, Enrico, additional, Utili, Riccardo, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Carosi, Giampiero, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif‐Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Halim, Magid, additional, Liew, Yee‐Yun, additional, Tan, Ru‐San, additional, Logar, Mateja, additional, Mueller‐Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manuel, additional, Armero, Yolanda, additional, Azqueta, Manuel, additional, Castañeda, Ximena, additional, Cervera, Carlos, additional, Falces, Carlos, additional, Garcia‐de‐la‐Maria, Cristina, additional, Fita, Guillermina, additional, Gatell, Jose M., additional, Heras, Magda, additional, Llopis, Jaime, additional, Marco, Francesc, additional, Mestres, Carlos A., additional, Miró, José M., additional, Moreno, Asuncion, additional, Ninot, Salvador, additional, Paré, Carlos, additional, Pericas, Juan M., additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sitges, Marta, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez‐Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez‐Créixems, Marta, additional, Solis, Jorge, additional, Almirante, Benito, additional, Fernandez‐Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg‐Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Fowler, Vance G., additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Woods, Christopher W., additional, Lerakis, Stamatios, additional, Cantey, Robert, additional, Steed, Lisa, additional, Wray, Dannah, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara‐Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, Cabell, Christopher H., additional, Baloch, Khaula, additional, Dixon, Christy C., additional, Harding, Tina, additional, Jones‐Richmond, Marian, additional, Sanderford, Bob, additional, Stafford, Judy, additional, Anstrom, Kevin, additional, Bayer, Arnold S., additional, Karchmer, A. W., additional, Sexton, Daniel J., additional, Chu, Vivian, additional, Durack, David T., additional, Eykyn, Susannah, additional, and Moreillon, Phillipe, additional
Published: 2016
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44. Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke

Author: Barsic, Bruno, Dickerman, Stuart, Krajinovic, Vladimir, Pappas, Paul, Altclas, Javier, Carosi, Giampiero, Casabé, José H., Chu, Vivian H., Delahaye, Francois, Edathodu, Jameela, Fortes, Claudio Querido, Olaison, Lars, Pangercic, Ana, Patel, Mukesh, Rudez, Igor, Tamin, Syahidah Syed, Vincelj, Josip, Bayer, Arnold S., Wang, Andrew, Clara, Liliana, Sanchez, Marisa, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Casabé, José, Cortes, Claudia, Kogan, Silvia, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Eisen, Damon, Grigg, Leeanne, Street, Alan, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Harkness, John, Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, De Brito, Ana Cláudia Passos, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Strabelli, Tania Mara Varejao, Vieira, Marcelo Luiz Campos, De Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, De Oliveira Ramos, Auristela, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Santos, Marisa, Weksler, Clara, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Bukovski, Suzana, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, Kholy, Amani El, Mishaal, Marwa, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, Catherine, Doco Lecompte, Thanh, Selton Suty, Christine, Casalta, Jean Paul, Fournier, Pierre Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Violette, Jérémie, Chevalier, Florent, Jeu, Antoine, Rusinaru, Dan, Sorel, Claire, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Germa Christoph, Neuerburg, Carl, Mazaheri, Bahram, Naber, Christoph, Athanasia, Sofia, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, D. M. Vinod, Venugopal, Krishnan, Hannan, Margaret, Hurley, John, Cahan, Amos, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Tripodi, Marie Françoise, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante Mangoni, Emanuele, Irene, Mattucci, Ragone, Enrico, Utili, Riccardo, Cecchi, Enrico, Rosa, Francesco De, Forno, Davide, Imazio, Massimo, Trinchero, Rita, Tebini, Alessandro, Grossi, PAOLO ANTONIO, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Magri, Silvia, Signorini, Liana, Baban, Tania, Kanafani, Zeina, Kanj, Souha S., Sfeir, Jad, Yasmine, Mohamad, Abidin, Imran, Martínez, Eduardo Rivera, Nieto, Gabriel Israel Soto, Van Der Meer, Jan T. M., Chambers, Stephen, Murdoch, David R., Holland, David, Morris, Arthur, Raymond, Nigel, Read, Kerry, Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O. M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Vinogradova, Tatiana, Halim, Magid, Lum, Luh Nah, Tan, Ru San, Lejko Zupanc, Tatjana, Logar, Mateja, Mueller Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Del Rio, Ana, Falces, Carlos, Garcia De La Maria, Cristina, Fita, Guillermina, Gatell, Jose M., Marco, Francesc, Mestres, Carlos A., Miró, José M., Moreno, Asuncion, Ninot, Salvador, Paré, Carlos, Pericas, Joan, Ramirez, Jose, Rovira, Irene, Sitges, Marta, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Bouza, Emilio, Fernández, Miguel Angel Garcia, Gonzalez Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez Créixems, Marta, Solis, Jorge, Almirante, Benito, Fernandez Hidalgo, Nuria, Tornos, Pilar, De Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Snygg Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Corey, G. Ralph, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Lalani, Tahaniyat, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Woods, Christopher W., Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Wray, Dannah, Dickerman, Stuart A., Bonilla, Hector, Di Persio, Joseph, Salstrom, Sara Jane, Baddley, John, Peterson, Gail, Stancoven, Amy, Afonso, Luis, Kulman, Theresa, Levine, Donald, Rybak, Michael, Cabell, Christopher H., Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie (Hôpital Louis Pradel), Hospices Civils de Lyon (HCL), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, MESH: Endocarditis, Time Factors, Medizin, 030204 cardiovascular system & hematology, endocarditis, valve replacement, surgery, Cohort Studies, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 030212 general & internal medicine, Hospital Mortality, MESH: Inpatients, Stroke, MESH: Cohort Studies, MESH: Aged, MESH: Middle Aged, MESH: Cardiac Surgical Procedures, Endocarditis, Mortality rate, Hazard ratio, Middle Aged, stroke, 3. Good health, Cardiac surgery, Infectious Diseases, Infective endocarditis, Female, Cohort study, Adult, Microbiology (medical), medicine.medical_specialty, MESH: Stroke, 03 medical and health sciences, medicine, Humans, MESH: Hospital Mortality, Cardiac Surgical Procedures, Aged, Inpatients, MESH: Humans, Proportional hazards model, business.industry, MESH: Time Factors, MESH: Adult, Odds ratio, medicine.disease, MESH: Male, Surgery, business, MESH: Female
Abstract: International audience; BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were obtained from the International Collaboration on Endocarditis-Prospective Cohort Study of 4794 patients with definite IE who were admitted to 64 centers from June 2000 through December 2006. Multivariate logistic regression and Cox regression analyses were performed to estimate the impact of early surgery on hospital and 1-year mortality after adjustments for other significant covariates. RESULTS: Of the 857 patients with IE complicated by ischemic stroke syndromes, 198 who underwent valve replacement surgery poststroke were available for analysis. Overall, 58 (29.3%) patients underwent early surgical treatment vs 140 (70.7%) patients who underwent late surgical treatment. After adjustment for other risk factors, early surgery was not significantly associated with increased in-hospital mortality rates (odds ratio, 2.308; 95% confidence interval [CI], .942-5.652). Overall, probability of death after 1-year follow-up did not differ between 2 treatment groups (27.1% in early surgery and 19.2% in late surgery group, P = .328; adjusted hazard ratio, 1.138; 95% CI, .802-1.650). CONCLUSIONS: There is no apparent survival benefit in delaying surgery when indicated in IE patients after ischemic stroke. Further observational analyses that include detailed pre- and postoperative clinical neurologic findings and advanced imaging data (eg, ischemic stroke size), may allow for more refined recommendations on the optimal timing of valvular surgery in patients with IE and recent stroke syndromes.
Published: 2013
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45. HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort

Author: Chambers, Stephen T, Murdoch, David, Morris, Arthur, Holland, David, Pappas, Paul, Almela, Manel, Fernández Hidalgo, Nuria, Almirante, Benito, Bouza, Emilio, Forno, Davide, Rio, Ana del, Hannan, Margaret M., Harkness, John, Kanafani, Zeina A., Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W., Wray, Dannah, Corey, G. Ralph, Chu, Vivian H., Clara, Liliana, Sanchez, Marisa, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Casabé, José, Cortes, Claudia, Altclas, Javier, Silvia Kogan, Sanatorio, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Eisen, Damon, Grigg, Leeanne, Street, Alan, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, de Brito, Ana Cláudia Passos, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Strabelli, Tania Mara Varejao, Vieira, Marcelo Luiz Campos, de Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, Fortes, Claudio Querido, de Oliveira Ramos, Auristela, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Santos, Marisa, Weksler, Clara, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Barsic, Bruno, Bukovski, Suzana, Krajinovic, Vladimir, Pangercic, Ana, Rudez, Igor, Vincelj, Josip, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, Kholy, Amani El, Mishaal, Marwa, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, Catherine, Doco Lecompte, Thanh, Selton Suty, Christine, Casalta, Jean Paul, Fournier, Pierre Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Francois, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Violette, Jérémie, Chevalier, Florent, Jeu, Antoine, Rusinaru, Dan M. D., Sorel, Claire, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Christoph, Neuerburg, Carl, Mazaheri, Bahram, Athanasia, Sofia, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, Vinod, Venugopal, Krishnan, Hannan, Margaret, Hurley, John, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Tripodi, Marie Françoise, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante Mangoni, Emanuele, Irene, Mattucci, Ragone, Enrico, Utili, Riccardo, Cecchi, Enrico, De Rosa, Francesco, Imazio, Massimo, Trinchero, Rita, Tebini, Alessandro, Grossi, PAOLO ANTONIO, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Carosi, Giampiero, Magri, Silvia, Signorini, Liana, Baban, Tania, Kanafani, Zeina, Kanj, Souha S., Sfeir, Jad, Yasmine, Mohamad, Abidin, Imran, Tamin, Syahidah Syed, Martínez, Eduardo Rivera, Nieto, Gabriel Israel Soto, van der Meer, Jan T. M., Chambers, Stephen, Murdoch, David R., Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O. M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Edathodu, Jameela, Halim, Magid, Lum, Luh Nah, Tan, Ru San, Lejko Zupanc, Tatjana, Logar, Mateja, Mueller Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Falces, Carlos, Garcia de la Maria, Cristina, Fita, Guillermina, Gatell, Jose M., Marco, Francesc, Mestres, Carlos A., Miró, José M., Moreno, Asuncion, Ninot, Salvador, Paré, Carlos, Pericas, Joan, Ramirez, Jose, Rovira, Irene, Sitges, Marta, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Fernández, Miguel Angel Garcia, Gonzalez Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez Créixems, Marta, Solis, Jorge, Fernandez Hidalgo, Nuria, Tornos, Pilar, de Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Olaison, Lars, Snygg Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Wang, Andrew, Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Dickerman, Stuart A., Bonilla, Hector, Dipersio, Joseph, Salstrom, Sara Jane, Baddley, John, Patel, Mukesh, Peterson, Gail, Stancoven, Amy, Afonso, Luis, Kulman, Theresa, Levine, Donald, Rybak, Michael, Cabell, Christopher H., Baloch, Khaula, Dixon, Christy C., Vance G., Fowler J. r., Harding, Tina, Jones Richmond, Marian, Park, Lawrence P., Redick, Thomas, Stafford, Judy, Anstrom, Kevin, Bayer, Arnold S., Karchmer, A. W., Sexton, Daniel J., Cabell, Christopher H, Chu, Vivian, Durack, David T., Eykyn, Susannah, Moreillon, Phillipe, Universitat de Barcelona, University of Otago [Dunedin, Nouvelle-Zélande], Auckland City Hospital, Microbiology Laboratory, Middlemore Hospital, Duke University Medical Center, Clinical and experimental neuroimmunology [IDIBAPS], Institut d'Investigacions Biomèdiques August Pi i Sunyer, Vall d'Hebron University Hospital [Barcelona], Hospital Universitario Gregorio Maranon, Hospital Universitario Gregorio Marañón, Cardiologie, Maria Vittoria Hospital [Turin], Mater Hospitals, University of New South Wales [Sydney] (UNSW), American University of Beirut [Beyrouth] (AUB), Uniformed Services University of the Health Sciences (USUHS), Wellington Hospital Private, Royal North Shore Hospital (RNSH), Russian State Medical University, Durham VA Medical Center, and University of South Carolina [Columbia]
Subjects: Aortic valve, Bacterial Diseases, Genetics and Molecular Biology (all), Valvular Disease, Medizin, Eikenella corrodens, Cardiobacterium, Infection control, Cardiovascular, American-heart-association, Biochemistry, Antimicrobial therapy, Cohort Studies, 0302 clinical medicine, Control d'infeccions, Diagnosis, Odds Ratio, Prevalence, 030212 general & internal medicine, Prospective cohort study, Haemophilus Influenzae, 0303 health sciences, Multidisciplinary, biology, Endocarditis, Medicine (all), Statistics, Congenital Heart Disease, Age Factors, Bacterial, 3. Good health, Management, Stroke, medicine.anatomical_structure, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Treatment Outcome, Infective endocarditis, Cohort, [SDV.IMM]Life Sciences [q-bio]/Immunology, Medicine, Profile, Health-care professionals, Kingella, Cardiobacterium-hominis, Cohort study, Research Article, medicine.medical_specialty, Drugs and Devices, Science, Haemophilus, Referral bias, Statistics, Nonparametric, Medical Devices, 03 medical and health sciences, Internal medicine, Kingella Kingae Infection, medicine, Humans, Nonparametric, Aggregatibacter, Endocarditis, Bacterial, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Staphylococcus-aureus, Heart Failure, 030306 microbiology, business.industry, Acute Cardiovascular Problems, Bloodstream Infections, medicine.disease, biology.organism_classification, Surgery, Valve endocarditis, Cardiobacterium hominis, business
Abstract: International audience; The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p < 0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p < 0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p < 0.01) and younger age (OR 0.62; CI 0.49-0.90; p < 0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p < 0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.
Published: 2013
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46. Candida infective endocarditis: an observational cohort study with a focus on therapy

Author: Arnold, Christopher J., Johnson, Melissa, Bayer, Arnold S., Bradley, Suzanne, Giannitsioti, Efthymia, Miró, José M., Tornos, Pilar, Tattevin, Pierre, Strahilevitz, Jacob, Spelman, Denis, Athan, Eugene, Nacinovich, Francisco, Fortes, Claudio Q., Lamas, Cristiane, Barsic, Bruno, Fernández-Hidalgo, Nuria, Muñoz, Patricia, Chu, Vivian H., Arnold, Christopher J., Johnson, Melissa, Bayer, Arnold S., Bradley, Suzanne, Giannitsioti, Efthymia, Miró, José M., Tornos, Pilar, Tattevin, Pierre, Strahilevitz, Jacob, Spelman, Denis, Athan, Eugene, Nacinovich, Francisco, Fortes, Claudio Q., Lamas, Cristiane, Barsic, Bruno, Fernández-Hidalgo, Nuria, Muñoz, Patricia, and Chu, Vivian H.
Abstract: Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous infective endocarditis (26%) were common comorbidities. Overall mortality was high, with 36% mortality in the hospital and 59% at 1 year. On univariate analysis, older age, heart failure at baseline, persistent candidemia, nosocomial acquisition, heart failure as a complication, and intracardiac abscess were associated with higher mortality. Mortality was not affected by use of surgical therapy or choice of antifungal agent. A subgroup analysis was performed on 33 patients for whom specific antifungal therapy information was available. In this subgroup, 11 patients received amphotericin B-based therapy and 14 received echinocandin-based therapy. Despite a higher percentage of older patients and nosocomial infection in the echinocandin group, mortality rates were similar between the two groups. In conclusion, Candida infective endocarditis is associated with a high mortality rate that was not impacted by choice of antifungal therapy or by adjunctive surgical intervention. Additionally, echinocandin therapy was as effective as amphotericin B-based therapy in the small subgroup analysis.
Published: 2015

47. Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis

Author: Erdem, Hakan, primary, Cag, Yasemin, additional, Ozturk-Engin, Derya, additional, Defres, Sylviane, additional, Kaya, Selcuk, additional, Larsen, Lykke, additional, Poljak, Mario, additional, Barsic, Bruno, additional, Argemi, Xavier, additional, Sørensen, Signe Maj, additional, Bohr, Anne Lisbeth, additional, Tattevin, Pierre, additional, Gunst, Jesper Damsgaard, additional, Baštáková, Lenka, additional, Jereb, Matjaž, additional, Johansen, Isik Somuncu, additional, Karabay, Oguz, additional, Pekok, Abdullah Umut, additional, Sipahi, Oguz Resat, additional, Chehri, Mahtab, additional, Beraud, Guillaume, additional, Shehata, Ghaydaa, additional, Del Vecchio, Rosa Fontana, additional, Maresca, Mauro, additional, Karsen, Hasan, additional, Sengoz, Gonul, additional, Sunbul, Mustafa, additional, Yilmaz, Gulden, additional, Yilmaz, Hava, additional, Sharif-Yakan, Ahmad, additional, Kanj, Souha Shararah, additional, Parlak, Emine, additional, Pehlivanoglu, Filiz, additional, Korkmaz, Fatime, additional, Komur, Suheyla, additional, Kose, Sukran, additional, Ulug, Mehmet, additional, Bolukcu, Sibel, additional, Coskuner, Seher Ayten, additional, Ince, Nevin, additional, Akkoyunlu, Yasemin, additional, Halac, Gulistan, additional, Sahin-Horasan, Elif, additional, Tireli, Hulya, additional, Kilicoglu, Gamze, additional, Al-Mahdawi, Akram, additional, Nemli, Salih Atakan, additional, Inan, Asuman, additional, Senbayrak, Seniha, additional, Stahl, Jean Paul, additional, and Vahaboglu, Haluk, additional
Published: 2015
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48. Candida Infective Endocarditis: an Observational Cohort Study with a Focus on Therapy

Author: Arnold, Christopher J., primary, Johnson, Melissa, additional, Bayer, Arnold S., additional, Bradley, Suzanne, additional, Giannitsioti, Efthymia, additional, Miró, José M., additional, Tornos, Pilar, additional, Tattevin, Pierre, additional, Strahilevitz, Jacob, additional, Spelman, Denis, additional, Athan, Eugene, additional, Nacinovich, Francisco, additional, Fortes, Claudio Q., additional, Lamas, Cristiane, additional, Barsic, Bruno, additional, Fernández-Hidalgo, Nuria, additional, Muñoz, Patricia, additional, and Chu, Vivian H., additional
Published: 2015
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49. Induced hypothermia in adult community-acquired bacterial meningitis – more than just a possibility?

Author: Lepur, Dragan, Kutleša, Marko, and Baršić, Bruno
Published: 2011
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50. First cases of human Usutu virus neuroinvasive infection in Croatia, August–September 2013: clinical and laboratory features

Author: Santini, Marija, primary, Vilibic-Cavlek, Tatjana, additional, Barsic, Bruno, additional, Barbic, Ljubo, additional, Savic, Vladimir, additional, Stevanovic, Vladimir, additional, Listes, Eddy, additional, Di Gennaro, Annapia, additional, and Savini, Giovanni, additional
Published: 2014
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