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1. Asociación entre índice tobillo-brazo y rendimiento cognitivo en participantes del estudio PREDIMED-Plus: estudio transversal

Author

López, Meritxell, Ríos, Angel, Romaguera, Dora, Martínez-González, Miguel Ángel, Fernández-Aranda, Fernando, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Vioque, Jesús, Alonso-Gómez, Ángel M., Crespo-Oliva, Edelys, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., García-Ríos, Antonio, Bueno-Cavanillas, Aurora, Gaforio, José J., Matía-Martín, Pilar, Daimiel, Lidia, Sánchez-Rodríguez, Rubén, Vidal, Josep, Sanz-Martínez, Enrique, Ros, Emilio, Toledo, Estefanía, Barrubés, Laura, Barragán, Rocío, de la Torre, Rafael, Fiol, Miquel, González-Palacios, Sandra, Sorto-Sánchez, Carolina, Martín-Ruiz, María Victoria, Zulet, María Ángeles, Díaz-Collado, Fátima, Casas, Rosa, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Mallorqui-Bagué, Nuria, Argelich, Emma, Lecea, Óscar, Paz-Graniel, Indira, Sorlí, José V., Cuenca, Aida, Munuera, Susana, Hernándis-Marsán, María Vicenta, Vaquero-Luna, Jessica, Ruiz-Canela, Miguel, Camacho-Barcia, Lucía, Jiménez-Murcia, Susana, Castañer, Olga, and Yáñez, Aina M.

Published
2021
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2. Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED-Plus study

Author

Paz-Graniel, Indira, Babio, Nancy, Serra-Majem, Luís, Vioque, Jesús, Zomeño, Maria Dolores, Corella, Dolores, Díaz-López, Andrés, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Daimiel, Lidia, Martínez, J. Alfredo, Becerra-Tomás, Nerea, Navarrete-Muñoz, Eva Mª, Schröder, Helmut, Fernández-Carrión, Rebeca, Ortiz-Andrellucchi, Adriana, Corbella, Emili, Riquelme-Gallego, Blanca, Gallardo-Alfaro, Laura, Micó, Víctor, Zulet, Marian, Barrubés, Laura, Fitó, Montserrat, Ruiz-Canela, Miguel, and Salas-Salvadó, Jordi

Published
2020
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4. Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment

Author

López, Meritxell, primary, Ríos, Angel, additional, Romaguera, Dora, additional, Martínez-González, Miguel Ángel, additional, Fernández-Aranda, Fernando, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Crespo-Oliva, Edelys, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, García-Ríos, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Sánchez-Rodríguez, Rubén, additional, Vidal, Josep, additional, Sanz-Martínez, Enrique, additional, Ros, Emilio, additional, Toledo, Estefanía, additional, Barrubés, Laura, additional, Barragán, Rocío, additional, de la Torre, Rafael, additional, Fiol, Miquel, additional, González-Palacios, Sandra, additional, Sorto-Sánchez, Carolina, additional, Martín-Ruiz, María Victoria, additional, Zulet, María Ángeles, additional, Díaz-Collado, Fátima, additional, Casas, Rosa, additional, Fernández-García, José Carlos, additional, Santos-Lozano, José Manuel, additional, Mallorqui-Bagué, Nuria, additional, Argelich, Emma, additional, Lecea, Óscar, additional, Paz-Graniel, Indira, additional, Sorlí, José V., additional, Cuenca, Aida, additional, Munuera, Susana, additional, Hernándis-Marsán, María Vicenta, additional, Vaquero-Luna, Jessica, additional, Ruiz-Canela, Miguel, additional, Camacho-Barcia, Lucía, additional, Jiménez-Murcia, Susana, additional, Castañer, Olga, additional, and Yáñez, Aina M., additional

Published
2021
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5. Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis

Author

Becerra-Tomás, Nerea, primary, Paz-Graniel, Indira, additional, Tresserra-Rimbau, Anna, additional, Martínez-González, Miguel Á., additional, Barrubés, Laura, additional, Corella, Dolores, additional, Muñoz-Martínez, Júlia, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, José A., additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Bernal-López, Maria R., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, Garcia-Rios, Antonio, additional, Riquelme Gallego, Blanca, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Velilla-Zancada, Sonsoles, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Babio, Nancy, additional, Fernández-Carrión, Rebeca, additional, Pérez-Vega, Karla A., additional, Morey, Marga, additional, Torres-Collado, Laura, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jessica, additional, Abete, Itziar, additional, Cabrera, Judith P., additional, Casas, Rosa, additional, Fernández-García, José C., additional, Santos-Lozano, José M., additional, Esteve-Luque, Virginia, additional, Bouzas, Cristina, additional, Fernandez-Lazaro, Cesar I., additional, Sorlí, José V., additional, Freixer, Gala, additional, Martín, Marian, additional, Muñoz, Montserrat G., additional, Salaverria-Lete, Itziar, additional, Toledo, Estefania, additional, Castañer, Olga, additional, and Salas-Salvadó, Jordi, additional

Published
2021
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6. Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study

Author

Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Nafarroako Gobernua, Fundación Patrimonio Comunal Olivarero, Hojiblanca, Institución Catalana de Investigación y Estudios Avanzados, California Walnut Commission, Borges, Morella Nuts, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Educación, Cultura y Deporte (España), Barrubés, Laura, Babio, Nancy, Hernández-Alonso, Pablo, Toledo, Estefania, Ramírez Sabio, Judith B., Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Alonso-Gómez, Ángel M., Fiol, Miquel, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Ruiz-Canela, Miguel, Corella, Dolores, Macías-González, Manuel, Salas-Salvadó, Jordi, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat Valenciana, Generalitat de Catalunya, Nafarroako Gobernua, Fundación Patrimonio Comunal Olivarero, Hojiblanca, Institución Catalana de Investigación y Estudios Avanzados, California Walnut Commission, Borges, Morella Nuts, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Educación, Cultura y Deporte (España), Barrubés, Laura, Babio, Nancy, Hernández-Alonso, Pablo, Toledo, Estefania, Ramírez Sabio, Judith B., Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Alonso-Gómez, Ángel M., Fiol, Miquel, Lapetra, José, Serra-Majem, Lluis, Pintó, Xavier, Ruiz-Canela, Miguel, Corella, Dolores, Macías-González, Manuel, and Salas-Salvadó, Jordi

Abstract

Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4–7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63–0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64–0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future.

Published
2020

7. U-Shaped Association between Dietary Acid Load and Risk of Osteoporotic Fractures in 2 Populations at High Cardiovascular Risk

Author

García-Gavilán, Jesús Francisco, primary, Martínez, Alfredo, additional, Konieczna, Jadwiga, additional, Mico-Perez, Rafael, additional, García-Arellano, Ana, additional, Basora, Josep, additional, Barrubés, Laura, additional, Goday, Alberto, additional, Canudas, Silvia, additional, Salas-Salvadó, Jordi, additional, and Bulló, Monica, additional

Published
2021
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8. Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study

Author

Barrubés, Laura, primary, Babio, Nancy, additional, Hernández-Alonso, Pablo, additional, Toledo, Estefania, additional, Ramírez Sabio, Judith B., additional, Estruch, Ramón, additional, Ros, Emilio, additional, Fitó, Montserrat, additional, Alonso-Gómez, Angel M, additional, Fiol, Miquel, additional, Lapetra, Jose, additional, Serra-Majem, Lluís, additional, Pintó, Xavier, additional, Ruiz-Canela, Miguel, additional, Corella, Dolores, additional, Castañer, Olga, additional, Macías-González, Manuel, additional, and Salas-Salvadó, Jordi, additional

Published
2020
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10. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk

Author

Julibert, Alicia, primary, Bibiloni, Maria, additional, Bouzas, Cristina, additional, Martínez-González, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Maria, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, J., additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco, additional, Lapetra, José, additional, Pintó, Xavier, additional, Lopez-Miranda, José, additional, García-Molina, Laura, additional, Gaforio, José, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emili, additional, Toledo, Estefanía, additional, Becerra-Tomás, Nerea, additional, Pórtoles, Olga, additional, Pérez-Vega, Karla, additional, Fiol, Miquel, additional, Torres-Collado, Laura, additional, Tojal-Sierra, Lucas, additional, Carabaño-Moral, Rosa, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Bernal-López, María, additional, Santos-Lozano, José, additional, Galera, Ana, additional, Ugarriza, Lucía, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Coltell, Oscar, additional, Schröder, Helmut, additional, Konieczna, Jadwiga, additional, Orozco-Beltrán, Domingo, additional, Sorto-Sánchez, Carolina, additional, Eguaras, Sonia, additional, Barrubés, Laura, additional, Fitó, Montserrat, additional, Tur, Josep, additional, and Investigators, PREDIMED-PLUS, additional

Published
2019
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11. Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED-Plus study

Author

Paz-Graniel, Indira, primary, Babio, Nancy, additional, Serra-Majem, Luís, additional, Vioque, Jesús, additional, Zomeño, Maria Dolores, additional, Corella, Dolores, additional, Díaz-López, Andrés, additional, Pintó, Xavier, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Daimiel, Lidia, additional, Martínez, J. Alfredo, additional, Becerra-Tomás, Nerea, additional, Navarrete-Muñoz, Eva Mª, additional, Schröder, Helmut, additional, Fernández-Carrión, Rebeca, additional, Ortiz-Andrellucchi, Adriana, additional, Corbella, Emili, additional, Riquelme-Gallego, Blanca, additional, Gallardo-Alfaro, Laura, additional, Micó, Víctor, additional, Zulet, Marian, additional, Barrubés, Laura, additional, Fitó, Montserrat, additional, Ruiz-Canela, Miguel, additional, and Salas-Salvadó, Jordi, additional

Published
2019
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15. Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk.

Author

Barrubés, Laura, Babio, Nancy, Mena‐Sánchez, Guillermo, Toledo, Estefania, Ramírez‐Sabio, Judith B., Estruch, Ramón, Ros, Emilio, Fitó, Montserrat, Arós, Fernando, Fiol, Miquel, Santos‐Lozano, José Manuel, Serra‐Majem, Lluís, Pintó, Xavier, Martínez‐González, Miguel Ángel, Sorlí, José Vicente, Basora, Josep, Salas‐Salvadó, Jordi, and on behalf of the PREvención con DIeta MEDiterránea Study Investigators

Abstract

Prospective studies have reported an inverse association between the consumption of total dairy products and milk and the risk of colorectal cancer (CRC). Nonetheless, there is little and inconsistent evidence regarding subtypes of dairy product and CRC risk. We assessed the associations between the consumption of total dairy products, their different subtypes and CRC risk in older Mediterranean individuals at high cardiovascular risk. We analyzed data from 7,216 men and women (55–80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Individuals were recruited between 2003 and 2009 and followed up until December 2012. At baseline and yearly thereafter, consumption of total and specific dairy products was assessed using a validated 137‐item food‐frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC incidence were estimated for tertiles of mean consumption of dairy products during the follow‐up. During a median [interquartile range] follow‐up of 6.0 [4.4–7.3] years, we documented 101 incident CRC cases. In the multivariable‐adjusted models, HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme tertiles of total dairy product and low‐fat milk consumption were 0.55 (95% CI: 0.31–0.99; p‐trend = 0.037) and 0.54 (95% CI: 0.32–0.92; p‐trend = 0.022), respectively. No significant associations with other dairy products (whole‐fat and low‐fat dairy products; total, low‐fat and whole‐fat yogurt; cheese; total, low‐fat and whole‐fat milk; concentrated full‐fat dairy products, sugar‐enriched dairy products and fermented dairy products) were found. A high consumption of total dairy products and low‐fat milk was significantly associated with a reduced CRC risk. [ABSTRACT FROM AUTHOR]

Published
2018
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16. In vitroMetabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds: An Update

Author

Catalán, Úrsula, Barrubés, Laura, Valls, Rosa Maria, Solà, Rosa, and Rubió, Laura

Abstract

Dietary phenolic compounds(PCs) have been receiving interest for their presumed roles in disease prevention. However, there is a lack of studies on the underlying molecular mechanisms. In this regard, in vitrometabolomicapproaches are suitable for the investigation of the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been examined for PCs from rosemary (Rosmarinus officinalis), olive oil, and resveratrol using cell-basedmetabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vitrocell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro- and micro-nutrient metabolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerative diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitrometabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are needed and testing the physiological conjugated forms of PCs in these cell systems could be of special interest.

Published
2017
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17. Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study.

Author

Cano-Ibáñez N, Bueno-Cavanillas A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Freixer GL, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, García-Ríos A, García-Molina L, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Bartolomé-Resano J, Palau-Galindo A, Portoles O, Torres L, Miquel-Fiol, Sánchez MTC, Sorto-Sánchez C, Moreno-Morales N, Abete I, Álvarez-Pérez J, Sacanella E, Bernal-López MR, Santos-Lozano JM, Fanlo-Maresma M, Bouzas C, Razquin C, Becerra-Tomás N, Ortega-Azorin C, LLimona R, Morey M, Román-Maciá J, Goicolea-Güemez L, Vázquez-Ruiz Z, Barrubés L, Fitó M, and Gea A

Subjects
Aged, Cardiovascular Diseases complications, Cardiovascular Diseases prevention & control, Female, Follow-Up Studies, Humans, Male, Metabolic Syndrome complications, Metabolic Syndrome prevention & control, Middle Aged, Obesity complications, Obesity prevention & control, Overweight complications, Overweight prevention & control, Risk Factors, Spain, Time Factors, Cardiovascular Diseases diet therapy, Diet, Mediterranean, Metabolic Syndrome diet therapy, Nutritional Status, Obesity diet therapy, Overweight diet therapy
Abstract

Background: The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the prevention and better control of MetS. However, it is needed to show that nutritional interventions promoting the MedDiet are able to improve nutrient intake., Objective: To assess the effect of improving MedDiet adherence on nutrient density after 1 year of follow-up at the PREDIMED-Plus trial., Methods: We assessed 5777 men (55-75 years) and women (60-75 years) with overweight or obesity and MetS at baseline from the PREDIMED-Plus trial. Dietary changes and MedDiet adherence were evaluated at baseline and after 1 year. The primary outcome was the change in nutrient density (measured as nutrient intake per 1000 kcal). Multivariable-adjusted linear regression models were fitted to analyse longitudinal changes in adherence to the MedDiet and concurrent changes in nutrient density., Results: During 1-year follow-up, participants showed improvements in nutrient density for all micronutrients assessed. The density of carbohydrates (- 9.0%), saturated fatty acids (- 10.4%) and total energy intake (- 6.3%) decreased. These changes were more pronounced in the subset of participants with higher improvements in MedDiet adherence., Conclusions: The PREDIMED-Plus dietary intervention, based on MedDiet recommendations for older adults, maybe a feasible strategy to improve nutrient density in Spanish population at high risk of cardiovascular disease with overweight or obesity.

Published
2020
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