Search

Your search keyword '"Barros, H"' showing total 1,837 results
Start Over Author "Barros, H"
1,837 results on '"Barros, H"'

1. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta‐analysis of European, North American and Australian cohorts

Author

Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, LJ, Bergström, A, Charles, M‐A, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbø, M, Fantini, MP, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz‐Picciotto, I, Heude, B, Hivert, M‐F, Hryhorczuk, D, Huang, R‐C, Inskip, H, Karvonen, AM, Kenny, LC, Koletzko, B, Küpers, LK, Lagström, H, Lehmann, I, Magnus, P, Majewska, R, Mäkelä, J, Manios, Y, McAuliffe, FM, McDonald, SW, Mehegan, J, Melén, E, Mommers, M, Morgen, CS, Moschonis, G, Murray, D, Chaoimh, C Ní, Nohr, EA, Andersen, A‐M Nybo, Oken, E, Oostvogels, AJJM, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas‐Shiman, SL, Roeleveld, N, Ronfani, L, Santos, AC, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Turner, S, Gelder, MMHJ, Rossem, L, Berg, A, Vrijheid, M, Vrijkotte, TGM, West, J, Wijga, AH, Wright, J, Zvinchuk, O, Sørensen, TIA, Lawlor, DA, Gaillard, R, and Jaddoe, VWV

Subjects
Obesity, Contraception/Reproduction, Diabetes, Preterm, Low Birth Weight and Health of the Newborn, Infant Mortality, Cardiovascular, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Prevention, Nutrition, Pediatric, Aetiology, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, 2.1 Biological and endogenous factors, Prevention of disease and conditions, and promotion of well-being, Metabolic and endocrine, Reproductive health and childbirth, Good Health and Well Being, Adult, Australia, Birth Weight, Body Mass Index, Cohort Studies, Europe, Female, Gestational Age, Gestational Weight Gain, Humans, Infant, Newborn, North America, Odds Ratio, Overweight, Pregnancy, Pregnancy Complications, Risk Factors, Birthweight, body mass index, pregnancy complications, preterm birth, weight gain, Medical and Health Sciences, Obstetrics & Reproductive Medicine
Abstract

ObjectiveTo assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta-analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain.ConclusionsMaternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.Tweetable abstractPromoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.

Published
2019

3. Insomnia and nightmare profiles during the COVID-19 pandemic in Portugal: characterization and associated factors

Author

Santos, Ana Cristina, Ribeiro, Ana Isabel, Rocha, Artur, Lopes, Carla, Correia, Daniela, Ramos, Elisabete, Gonçalves, Gonçalo, Barros, Henrique, Araújo, Joana, Talih, Makram, Tavares, Margarida, Severo, Milton, Lunet, Nuno, Meireles, Paula, Duarte, Raquel, Lucas, Raquel, Camacho, Rui, Fraga, Sílvia, Correia, Sofia, Silva, Susana, Leão, Teresa, Goncalves, M., Henriques, A., Costa, A.R., Correia, D., Severo, M., Lucas, R., and Barros, H.

Published
2022
Full Text
View/download PDF

6. The Latin American Giant Observatory: Contributions to the 34th International Cosmic Ray Conference (ICRC 2015)

Author

The LAGO Collaboration, Alvarez, W., Alvarez, C., Araujo, C., Areso, O., Arnaldi, H., Asorey, H., Audelo, M., Barros, H., Bertou, X., Bonnett, M., Calderon, R., Calderon, M., Campos-Fauth, A., Carramiñana, A., Carrasco, E., Carrera, E., Cazar, D., Cifuentes, E., Cogollo, D., Conde, R., Cotzomi, J., Dasso, S., De Castro, A., De La Torre, J., De León, R., Estupiñan, A., Galindo, A., Garcia, L., Berisso, M. Gómez, González, M., Guevara, W., Gulisano, A. M., Hernández, H., Jaimes, A., López, J., Mantilla, C., Martín, R., Martínez-Mendez, A., Martínez, O., Martins, E., Masías-Meza, J. J., Mayo-García, R., Melo, T., Mendoza, J., Miranda, P., Montes, E., Morales, E., Morales, I., Moreno, E., Murrugarra, C., Nina, C., Núñez, L. A., Núñez-Castiñeyra, A., Otiniano, L., Peña-Rodríguez, J., Perenguez, J., Pérez, H., Perez, Y., Perez, G., Pinilla-Velandia, S., Ponce, E., Quishpe, R., Quispe, F., Ramelli, M., Reyes, K., Rivera, H., Rodriguez, J., Rodríguez-Pascual, M., Romero, M., Rubio-Montero, A. J., Salazar, H., Salinas, J., Sarmiento-Cano, C., Sidelnik, I., Haro, M. Sofo, Suárez-Durán, M., Subieta, M., Tello, J., Ticona, R., Torres, I., Torres-Niño, L., Truyenque, J., Valencia-Otero, M., Vargas, S., Vásquez, N., Villasenor, L., Zamalloa, M., and Zavala, L.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Latin American Giant Observatory (LAGO) is an extended cosmic ray observatory composed by a network of water-Cherenkov detectors spanning over different sites located at significantly different altitudes (from sea level up to more than $5000$\,m a.s.l.) and latitudes across Latin America, covering a huge range of geomagnetic rigidity cut-offs and atmospheric absorption/reaction levels. This detection network is designed to measure the temporal evolution of the radiation flux at ground level with extreme detail. The LAGO project is mainly oriented to perform basic research in three branches: high energy phenomena, space weather and atmospheric radiation at ground level. LAGO is built and operated by the LAGO Collaboration, a non-centralized collaborative union of more than 30 institutions from ten countries. These are the contributions of the LAGO Collaboration to the 34th International Cosmic Ray Conference, 30 July - 6 August 2015, The Hague, The Netherlands, Comment: 9 proceedings, the 34th International Cosmic Ray Conference, 30 July - 6 August 2015, The Hague, The Netherlands; in PoS(ICRC2015)

Published
2016

11. Water Cherenkov Detectors response to a Gamma Ray Burst in the Large Aperture GRB Observatory

Author

Allard, D., Alvarez, C., Asorey, H., Barros, H., Bertou, X., Castillo, M., Chirinos, J. M., De Castro, A., Flores, S., Gonzalez, J., Berisso, M. Gomez, Grajales, J., Guada, C., Day, W. R. Guevara, Ishitsuka, J., Lopez, J. A., Martinez, O., Melfo, A., Meza, E., Loza, P. Miranda, Barbosa, E. Moreno, Murrugarra, C., Nunez, L. A., Ormachea, L. J. Otiniano, Perez, G., Perez, Y., Ponce, E., Quispe, J., Quintero, C., Rivera, H., Rosales, M., Rovero, A. C., Saavedra, O., Salazar, H., Tello, J. C., Peralda, R. Ticona, Varela, E., Velarde, A., Villasenor, L., Wahl, D., and Zamalloa, M. A.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Extragalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

In order to characterise the behaviour of Water Cherenkov Detectors (WCD) under a sudden increase of 1 GeV - 1 TeV background photons from a Gamma Ray Burst (GRB), simulations were conducted and compared to data acquired by the WCD of the Large Aperture GRB Observatory (LAGO). The LAGO operates arrays of WCD at high altitude to detect GRBs using the single particle technique. The LAGO sensitivity to GRBs is derived from the reported simulations of the gamma initiated particle showers in the atmosphere and the WCD response to secondaries., Comment: 5 pages, proceeding of the 31st ICRC 2009

Published
2009

12. The Large Aperture GRB Observatory

Author

Allard, D., Alvarez, C., Asorey, H., Barros, H., Bertou, X., Castillo, M., Chirinos, J. M., De Castro, A., Flores, S., Gonzalez, J., Berisso, M. Gomez, Grajales, J., Guada, C., Day, W. R. Guevara, Ishitsuka, J., Lopez, J. A., Martinez, O., Melfo, A., Meza, E., Loza, P. Miranda, Barbosa, E. Moreno, Murrugarra, C., Nunez, L. A., Ormachea, L. J. Otiniano, Perez, G., Perez, Y., Ponce, E., Quispe, J., Quintero, C., Rivera, H., Rosales, M., Rovero, A. C., Saavedra, O., Salazar, H., Tello, J. C., Peralda, R. Ticona, Varela, E., Velarde, A., Villasenor, L., Wahl, D., and Zamalloa, M. A.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Extragalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Large Aperture GRB Observatory (LAGO) is aiming at the detection of the high energy (around 100 GeV) component of Gamma Ray Bursts, using the single particle technique in arrays of Water Cherenkov Detectors (WCD) in high mountain sites (Chacaltaya, Bolivia, 5300 m a.s.l., Pico Espejo, Venezuela, 4750 m a.s.l., Sierra Negra, Mexico, 4650 m a.s.l). WCD at high altitude offer a unique possibility of detecting low gamma fluxes in the 10 GeV - 1 TeV range. The status of the Observatory and data collected from 2007 to date will be presented., Comment: 4 pages, proceeding of 31st ICRC 2009

Published
2009

13. Operating Water Cherenkov Detectors in high altitude sites for the Large Aperture GRB Observatory

Author

Allard, D., Alvarez, C., Asorey, H., Barros, H., Bertou, X., Castillo, M., Chirinos, J. M., De Castro, A., Flores, S., Gonzalez, J., Berisso, M. Gomez, Grajales, J., Guada, C., Day, W. R. Guevara, Ishitsuka, J., Lopez, J. A., Martinez, O., Melfo, A., Meza, E., Loza, P. Miranda, Barbosa, E. Moreno, Murrugarra, C., Nunez, L. A., Ormachea, L. J. Otiniano, Perez, G., Perez, Y., Ponce, E., Quispe, J., Quintero, C., Rivera, H., Rosales, M., Rovero, A. C., Saavedra, O., Salazar, H., Tello, J. C., Peralda, R. Ticona, Varela, E., Velarde, A., Villasenor, L., Wahl, D., and Zamalloa, M. A.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Extragalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Water Cherenkov Detectors (WCD) are efficient detectors for detecting GRBs in the 10 GeV - 1 TeV energy range using the single particle technique, given their sensitivity to low energy secondary photons produced by high energy photons when cascading in the atmosphere. The Large Aperture GRB Observatory (LAGO) operates arrays of WCD in high altitude sites (above 4500 m a.s.l.) in Bolivia, Mexico and Venezuela, with planned extension to Peru. Details on the operation and stability of these WCD in remote sites with high background rates of particles will be detailed, and compared to simulations. Specific issues due to operation at high altitude, atmospheric effects and solar activity, as well as possible hardware enhancements will also be presented., Comment: 5 pages, proceeding of 31st ICRC 2009

Published
2009

14. Deterministic single-photon source from a single ion

Author

Barros, H G, Stute, A, Northup, T E, Russo, C, Schmidt, P O, and Blatt, R

Subjects
Quantum Physics
Abstract

We realize a deterministic single-photon source from one and the same calcium ion interacting with a high-finesse optical cavity. Photons are created in the cavity with efficiency (88 +- 17)%, a tenfold improvement over previous cavity-ion sources. Results of the second-order correlation function are presented, demonstrating a high suppression of two-photon events limited only by background counts. The cavity photon pulse shape is obtained, with good agreement between experiment and simulation. Moreover, theoretical analysis of the temporal evolution of the atomic populations provides relevant information about the dynamics of the process and opens the way to future investigations of a coherent atom-photon interface.

Published
2009
Full Text
View/download PDF

16. Complete biochemical response below 0.1 ng/ml predicts long-term therapy-free survival of prostate cancer patients treated with salvage lymph node dissection via PSMA-radioguided surgery

Author

Knipper, S., primary, Lischewski, F., additional, Koehler, D., additional, Eiber, M., additional, van Leeuwen, F.W.B., additional, de Barros, H., additional, Berrens, A.C., additional, van Leeuwen, P., additional, van der Poel, H., additional, Ambrosini, F., additional, Falkenbach, F., additional, Budäus, L., additional, Steuber, T., additional, Graefen, M., additional, Tennstedt, P., additional, Gschwend, J.E., additional, Horn, T., additional, Heck, M.M., additional, and Maurer, T., additional

Published
2023
Full Text
View/download PDF

21. Raman spectroscopy of a single ion coupled to a high-finesse cavity

Author

Russo, C., Barros, H. G., Stute, A., Dubin, F., Phillips, E. S., Monz, T., Northup, T. E., Becher, C., Salzburger, T., Ritsch, H., Schmidt, P. O., and Blatt, R.

Subjects
Quantum Physics
Abstract

We describe an ion-based cavity-QED system in which the internal dynamics of an atom is coupled to the modes of an optical cavity by vacuum-stimulated Raman transitions. We observe Raman spectra for different excitation polarizations and find quantitative agreement with theoretical simulations. Residual motion of the ion introduces motional sidebands in the Raman spectrum and leads to ion delocalization. The system offers prospects for cavity-assisted resolved-sideband ground-state cooling and coherent manipulation of ions and photons., Comment: 8 pages, 6 figures

Published
2008
Full Text
View/download PDF

24. Calibration of a large water-Cherenkov detector at the Sierra Negra site of LAGO

Author

Alvarez, W., Alvarez, C., Araujo, C., Areso, O., Arnaldi, H., Asorey, H., Audelo, M., Barros, H., Bonnett, M., Calderon, R., Calderon, M., Campos-Fauth, A., Carramiñana, A., Carrasco, E., Carrera, E., Cazar, D., Cifuentes, E., Collogo, D., Conde, R., Cotzomi, J., Dasso, S., De Castro, A., De La Torre, J., De León, R., Estupiñan, A., Galindo, A., García, L., Gomez Berisso, M., González, M., Guevara, W., Gulisano, A.M., Hernández, H., Jaimes, A., López, J., Mantilla, C., Martín, R., Martinez-Mendez, A., Martínez, O., Martins, E., Macías-Meza, J.J., Mayo-García, R., Melo, T., Mendoza, J., Miranda, P., Montes, E., Morales, E., Morales, I., Moreno, E., Murrugarra, C., Nina, C., Núñez, L.A., Núñez-Castiñeyra, A., Otiniano, L., Peña-Rodríguez, J., Perenguez, J., Pérez, H., Pérez, Y., Pérez, G., Pinilla-Velandia, S., Ponce, E., Quishpe, R., Quispe, F., Ramelli, M., Reyes, K., Rivera, H., Rodriguez, J., Rodríguez-Ferreira, J., Rodríguez-Pascual, M., Romero, M., Rubio-Montero, A.J., Salazar, H., Salinas, J., Sarmiento-Cano, C., Sidelnik, I., Sofo Haro, M., Suárez-Durán, M., Subieta, M., Tello, J., Ticona, R., Torres, I., Torres-Niõ, L., Truyenque, J., Valencia-Otero, M., Vargas, S., Vásquez, N., Villaseñor, L., Zamalloa, M., Zavala, L., and Bonilla, M.

Published
2017
Full Text
View/download PDF

25. Life-course socio-economic status and its impact on functional health of Portuguese older adults.

Author

Henriques, A., Ruano, L., Fraga, S., Soares, S., Barros, H., and Talih, M.

Abstract

Functional health is arguably one of the most important health indicators for older adults, because it assesses physical, cognitive and social functions in combination. However, life-course circumstances may impact this multidimensional construct. The aim of the present study was to assess the relationship between life-course socio-economic status (SES) and different dimensions of functional health in older adults. Data on 821 Portuguese adults aged 50 years and over in 2013–2015 were analysed. Life-course SES was computed using participants' paternal occupation (non-manual (nm); manual (m)) and own occupation (nm; m), resulting in four patterns: stable high (nm + nm), upward (m + nm), downward (nm + m) and stable low (m + m). Functional health included physical and mental functioning, cognitive function, handgrip strength, and walking speed. Linear (beta coefficients) and logistic regressions (odds ratios) were used to estimate the association between life-course SES and functional health. Overall, those who accumulated social disadvantage during life-course presented worse functional health than those with stable high SES (stable low – SF-36 physical functioning: β = −9.75; 95% CI: −14.34; −5.15; SF-36 mental health: β = −7.33; 95% CI: −11.55; −3.11; handgrip strength: β = −1.60; 95% CI: −2.86; −0.35; walking time, highest tertile: OR = 5.28; 95% CI: 3.07; 9.09). Those with an upward SES were not statistically different from those in the stable high SES for most of the health outcomes; however, those with an upward SES trajectory tended to have higher odds of cognitive impairment (OR = 1.75; 95% CI: 0.96; 3.19). A downward SES trajectory increased the odds of slower walking speed (OR = 4.62; 95% CI: 1.78; 11.95). A disadvantaged life-course SES impacts older adults' physical and mental functioning. For some outcomes, this was attenuated by a favourable adulthood SES but those with a stable low SES consistently presented worse functional health. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

26. Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis

Author

McCrory, C., McLoughlin, S., Layte, R., NiCheallaigh, C., O'Halloran, A.M., Barros, H., Berkman, L.F., Bochud, M., M Crimmins, E., T Farrell, M., Fraga, S., Grundy, E., Kelly-Irving, M., Petrovic, D., Seeman, T., Stringhini, S., Vollenveider, P., and Kenny, R.A.

Subjects
Humans, Glycated Hemoglobin, Allostasis/physiology, Consensus, Biomarkers, C-Reactive Protein/analysis, Cohort Studies, Allostatic load, Biomarker, Cohort study, Cumulative physiological dysregulation, Individual participant data meta-analysis
Abstract

Allostatic load (AL) is a multi-system composite index for quantifying physiological dysregulation caused by life course stressors. For over 30 years, an extensive body of research has drawn on the AL framework but has been hampered by the lack of a consistent definition. This study analyses data for 67,126 individuals aged 40-111 years participating in 13 different cohort studies and 40 biomarkers across 12 physiological systems: hypothalamic-pituitary-adrenal (HPA) axis, sympathetic-adrenal-medullary (SAM) axis, parasympathetic nervous system functioning, oxidative stress, immunological/inflammatory, cardiovascular, respiratory, lipidemia, anthropometric, glucose metabolism, kidney, and liver. We use individual-participant-data meta-analysis and exploit natural heterogeneity in the number and type of biomarkers that have been used across studies, but a common set of health outcomes (grip strength, walking speed, and self-rated health), to determine the optimal configuration of parameters to define the concept. There was at least one biomarker within 9/12 physiological systems that was reliably and consistently associated in the hypothesised direction with the three health outcomes in the meta-analysis of these cohorts: dehydroepiandrosterone sulfate (DHEAS), low frequency-heart rate variability (LF-HRV), C-reactive protein (CRP), resting heart rate (RHR), peak expiratory flow (PEF), high density lipoprotein cholesterol (HDL-C), waist-to-height ratio (WtHR), HbA1c, and cystatin C. An index based on five biomarkers (CRP, RHR, HDL-C, WtHR and HbA1c) available in every study was found to predict an independent outcome - mortality - as well or better than more elaborate sets of biomarkers. This study has identified a brief 5-item measure of AL that arguably represents a universal and efficient set of biomarkers for capturing physiological 'wear and tear' and a further biomarker (PEF) that could usefully be included in future data collection.

Published
2023

32. Prediction of movement difficulties at 5 years from parent report at 2 years in children born extremely preterm

Author

Costa, Raquel, Aubert, Adrien M., Seppänen, Anna Veera, Aden, U., Sarrechia, I., Zemlin, M., Cuttini, M., Männamaa, M., Pierrat, V., van Heijst, A., Barros, H., Zeitlin, Jennifer, Johnson, Samantha, Carnielli, V., Costa, Raquel, Aubert, Adrien M., Seppänen, Anna Veera, Aden, U., Sarrechia, I., Zemlin, M., Cuttini, M., Männamaa, M., Pierrat, V., van Heijst, A., Barros, H., Zeitlin, Jennifer, Johnson, Samantha, and Carnielli, V.

Abstract

Aim: To assess the predictive validity of parent-reported gross motor impairment (GMI) at age 2 years to detect significant movement difficulties at age 5 years in children born extremely preterm. Method: Data were from 556 children (270 males, 286 females) born at less than 28 weeks' gestation in 2011 to 2012 in 10 European countries. Parent report of moderate/severe GMI was defined as walking unsteadily or unable to walk unassisted at 2 years corrected age. Examiners assessed significant movement difficulties (score ≤ 5th centile on the Movement Assessment Battery for Children, Second Edition) and diagnoses of cerebral palsy (CP) were collected by parent report at 5 years chronological age. Results: At 2 years, 66 (11.9%) children had moderate/severe GMI. At 5 years, 212 (38.1%) had significant movement difficulties. Parent reports of GMI at age 2 years accurately classified CP at age 5 years in 91.0% to 93.2% of children. Classification of moderate/severe GMI at age 2 years had high specificity (96.2%; 95% confidence interval 93.6–98.0) and positive predictive value (80.3%; 68.7–89.1) for significant movement difficulties at age 5 years. However, 74.5% of children with significant movement difficulties at 5 years were not identified with moderate/severe GMI at age 2 years, resulting in low sensitivity (25.1%; 19.4–31.5). Interpretation: This questionnaire may be used to identify children born extremely preterm who at age 2 years have a diagnosis of CP or movement difficulties that are likely to have a significant impact on their functional outcomes at age 5 years.

Published
2023

34. The data acquisition system of the Latin American Giant Observatory (LAGO)

Author

Alvarez, W., Alvarez, C., Araujo, C., Areso, O., Arnaldi, H., Asorey, H., Audelo, M., Barros, H., Bertou, X., Bonnett, M., Calderon, R., Calderon, M., Campos-Fauth, A., Carramiñana, A., Carrasco, E., Carrera, E., Cazar, D., Cifuentes, E., Cogollo, D., Conde, R., Cotzomi, J., Dasso, S., De Castro, A., De La Torre, J., De León, R., Estupiñan, A., Galindo, A., Garcia, L., Gómez Berisso, M., González, M., Guevara, W., Gulisano, A.M., Hernández, H., Jaimes, A., López, J., Mantilla, C., Martín, R., Martinez-Mendez, A., Martínez, O., Martins, E., Masías-Meza, J.J., Mayo-García, R., Melo, T., Mendoza, J., Miranda, P., Montes, E., Morales, E., Morales, I., Moreno, E., Murrugarra, C., Nina, C., Núñez, L.A., Núñez-Castiñeyra, A., Otiniano, L., Peña-Rodríguez, J., Perenguez, J., Pérez, H., Perez, Y., Perez, G., Pinilla-Velandia, S., Ponce, E., Quishpe, R., Quispe, F., Reyes, K., Rivera, H., Rodriguez, J., Rodríguez-Pascual, M., Romero, M., Rubio-Montero, A.J., Salazar, H., Salinas, J., Sarmiento-Cano, C., Sidelnik, I., Haro, M. Sofo, Suárez-Durán, M., Subieta, M., Tello, J., Ticona, R., Torres, I., Torres-Niño, L., Truyenque, J., Valencia-Otero, M., Vargas, S., Vásquez, N., Villasenor, L., Zamalloa, M., Zavala, L., Sofo Haro, M., and Arnaldi, L.H.

Published
2016
Full Text
View/download PDF

36. The contribution to policies of an exposome-based approach to childhood obesity

Author

Vineis, P, Handakas, E, Alfano, R, Millett, C, Fecht, D, Chatzi, L, Plusquin, M, Nawrot, T, Richiardi, L, Barros, H, Vrijheid, M, Sassi, F, Robinson, O, and Medical Research Council (MRC)

Subjects
Environmental Engineering
Abstract

Childhood obesity is an increasingly severe public health problem, with a prospective impact on health. We propose an exposome approach to identifying actionable risk factors for this condition. Our assumption is that relationships between external exposures and outcomes such as rapid growth, overweight or obesity in children can be better understood through a “meet-in-the-middle” model. This is based on a combination of external and internal exposome-based approaches, i.e. the study of multiple exposures (in our case dietary patterns) and molecular pathways (metabolomics and epigenetics). This may strengthen causal reasoning by identifying intermediate markers that are associated with both exposures and outcomes. Our biomarker-based studies in the STOP consortium suggest (in several ways, including mediation analysis) that Branched-Chain Amino Acids (BCAAs) could be mediators of the effect of dietary risk factors on childhood overweight/obesity. This is consistent with intervention and animal studies showing that higher intake of BCAAs has a positive impact on body composition, glycemia and satiety. Concerning food, of particular concern is the trend of increasing intake of ultra-processed food (UPF), including among children. Several mechanisms have been proposed to explain the impact of UPF on obesity and overweight, including nutrient intake (particularly proteins), changes in appetite or the role of additives. Research from the ALSPAC cohort has shown a relationship between UPF intake and trajectories in childhood adiposity, while UPF was related to lower blood levels of BCAAs. We suggest that an exposome-based approach can help strengthening causal reasoning and support policies. Intake of UPF in children should be restricted to prevent obesity.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results