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Your search keyword '"Barros, E.B."' showing total 11 results
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11 results on '"Barros, E.B."'

2. Recent Advances in Extracellular Vesicles as Drug Delivery Systems and Their Potential in Precision Medicine.

Author

Jong, B. De, Barros, E.B., Hoenderop, J.G.J., Rigalli, J.P., Jong, B. De, Barros, E.B., Hoenderop, J.G.J., and Rigalli, J.P.

Abstract

Contains fulltext : 229779.pdf (publisher's version ) (Open Access), Extracellular vesicles (EVs) are membrane-bilayered nanoparticles released by most cell types. Recently, an enormous number of studies have been published on the potential of EVs as carriers of therapeutic agents. In contrast to systems such as liposomes, EVs exhibit less immunogenicity and higher engineering potential. Here, we review the most relevant publications addressing the potential and use of EVs as a drug delivery system (DDS). The information is divided based on the key steps for designing an EV-mediated delivery strategy. We discuss possible sources and isolation methods of EVs. We address the administration routes that have been tested in vivo and the tissue distribution observed. We describe the current knowledge on EV clearance, a significant challenge towards enhancing bioavailability. Also, EV-engineering approaches are described as alternatives to improve tissue and cell-specificity. Finally, a summary of the ongoing clinical trials is performed. Although the application of EVs in the clinical practice is still at an early stage, a high number of studies in animals support their potential as DDS. Thus, better treatment options could be designed to precisely increase target specificity and therapeutic efficacy while reducing off-target effects and toxicity according to the individual requirements of each patient.

Published
2020

10. G′ band Raman lineshape analysis in graphitic foams

Author

Barros, E.B., Souza Filho, A.G., Son, H., and Dresselhaus, M.S.

Subjects
*SPECTRUM analysis, *RAMAN spectroscopy, *FOAM, *COLLOIDS
Abstract

Abstract: In this work we extend the study of the use of Raman spectroscopy to characterize graphitic foams by analyzing the dependence of the G′ band lineshape on both the excitation laser energy and on the topology of the studied area. The G′ band lineshape was found to be strongly correlated with the presence of stacking faults. The contribution of the combination mode at 2450cm−1 to the evaluated skewness includes an excitation energy dependence which needs to be considered. We analyze how to take this effect into consideration, thus obtaining a good evaluation of the dependence of the skewness of the G′ band on the presence of stacking faults. We also discuss the correlation between the presence of stacking faults and of in plane defects in graphitic foams. [Copyright &y& Elsevier]

Published
2007
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11. Lattice dynamic properties of interfaced InAs/GaAs superlattices

Author

Lemos, V., Barros, E.B., Freire, V.N., Gonçalves, J.R., and Mendes Filho, J.

Subjects
*LATTICE dynamics, *RAMAN effect
Abstract

The effect of interfaces in several InGaAs/GaAs SLs with In content x=0.3 and 1, were studied. Interface thickness of 0,1,2 and 3 MLs were considered. The Raman spectra for x=0.3 evolves from a two peaks feature to a single peak with increasing the interface thickness. The x=1 SLs Raman spectra change considerably by interfacing. Two weak features in the abrupt SL are observed to enhanced as the interface thickness is increased from one to three monolayers. The atomic displacements calculation reveals that most of the Raman modes of the InGaAs/GaAs or the InAs/GaAs SLs are extended or quasi-extended modes the case of interfaces with thickness of 3 MLs. [Copyright &y& Elsevier]

Published
2003
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