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This nonrandomized controlled trial compares the effectiveness of elastomeric half-mask respirators with that of N95 filtering facepiece respirators during cardiopulmonary resuscitation.

Additional file 2: Supplemental Figure 2. Prevalence of non-PE related mechanical ventilation requirement and shock among patients among (A) pre-PERT and PERT-era patients and (B) Pert activated and non-PERT activated subjects in the PERT era; MV, mechanical ventilation, shock is defined as hypotension requiring vasopressor medication. * p

Additional file 3: Supplementary Table 1 Performed risk assessment and severity of PE. Abbreviations: PP; pre-PERT; PA, PERT alerted; NPA, Non-PERT alerted; BNP, Brain natriuretic peptide; TTE, transthoracic echocardiogram; RV, right ventricle; CT, computer tomography. a) assessment within 12 h of pulmonary embolism diagnosis, b) positive RV strain by biomarkers was determined as troponin> 0.02 ng/mL, and/or BNP > 155 pg/mL; c) RV strain on CT imaging was determined as RV/LV ration (ratio of right ventricular to left ventricular diameter ration of > 0.9). P value calculated by Chi Square test.

Additional file 1: Supplemental Figure 1. Distribution of 2019 ESC risk categories among the 3 groups. ESC, European Society of Cardiology.

Rationale: The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an unprecedented event requiring rapid adaptation to changing clinical circumstances. Convalescent immune plasma (CIP) is a promising treatment that can be mobilized rapidly in a pandemic setting., Objectives: We tested whether administration of SARS-CoV-2 CIP at hospital admission could reduce the rate of ICU transfer or 28 day mortality., Methods: In a single-arm phase II study, patients >18 years-old with respiratory symptoms documented with COVID-19 infection who were admitted to a non-ICU bed were administered two units of CIP within 72 hours of admission. Detection of respiratory tract SARS-CoV-2 by polymerase chain reaction and circulating anti-SARS-CoV-2 antibody titers were measured before and at time points after CIP transfusion., Measurements and Main Results: Twenty-nine patients were transfused CIP and forty-eight contemporaneous controls were identified with comparable baseline characteristics. Levels of anti-SARS-CoV-2 IgG, IgM, and IgA anti-spike, anti-receptor-binding domain, and anti-nucleocapsid significantly increased from baseline to post-transfusion for all proteins tested. In patients transfused with CIP, the rate of ICU transfer was 13.8% compared to 27.1% for controls with a hazard ratio 0.506 (95% CI 0.165-1.554), and 28-day mortality was 6.9% compared to 10.4% for controls, hazard ratio 0.640 (95% CI 0.124-3.298)., Conclusions: Transfusion of high-titer CIP to patients early after admission with COVID-19 respiratory disease was associated with reduced ICU transfer and 28-day mortality but was not statistically significant. Follow up randomized trials may inform the use of CIP for COVID-19 or future coronavirus pandemics.