11 results on '"Barron RE"'
Search Results
2. Genetic and environmental influences on serum oxylipins, endocannabinoids, bile acids and steroids.
- Author
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Bermingham KM, Brennan L, Segurado R, Gray IJ, Barron RE, Gibney ER, Ryan MF, Gibney MJ, Newman JW, and O'Sullivan DAM
- Subjects
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid blood, 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid genetics, Adolescent, Adult, Aged, Bile Acids and Salts genetics, Dehydroepiandrosterone blood, Dehydroepiandrosterone genetics, Docosahexaenoic Acids blood, Docosahexaenoic Acids genetics, Eicosapentaenoic Acid analogs & derivatives, Eicosapentaenoic Acid blood, Eicosapentaenoic Acid genetics, Endocannabinoids genetics, Fatty Acids, Omega-3 genetics, Female, Gene-Environment Interaction, Humans, Male, Middle Aged, Twins, Dizygotic genetics, Twins, Monozygotic genetics, Young Adult, Bile Acids and Salts blood, Endocannabinoids blood, Fatty Acids, Omega-3 blood, Lipid Metabolism genetics, Oxylipins blood, Steroids blood
- Abstract
Lipid bioactivity is a result of direct action and the action of lipid mediators including oxylipins, endocannabinoids, bile acids and steroids. Understanding the factors contributing to biological variation in lipid mediators may inform future approaches to understand and treat complex metabolic diseases. This research aims to determine the contribution of genetic and environmental influences on lipid mediators involved in the regulation of inflammation and energy metabolism. This study recruited 138 monozygotic (MZ) and dizygotic (DZ) twins aged 18-65 years and measured serum oxylipins, endocannabinoids, bile acids and steroids using liquid chromatography mass-spectrometry (LC-MS). In this classic twin design, the similarities and differences between MZ and DZ twins are modelled to estimate the contribution of genetic and environmental influences to variation in lipid mediators. Heritable lipid mediators included the 12-lipoxygenase products 12-hydroxyeicosatetraenoic acid [0.70 (95% CI: 0.12,0.82)], 12-hydroxyeicosatetraenoic acid [0.73 (95% CI: 0.30,0.83)] and 14‑hydroxy-docosahexaenoic acid [0.51 (95% CI: 0.07,0.71)], along with the endocannabinoid docosahexaenoy-lethanolamide [0.52 (95% CI: 0.15,0.72)]. For others such as 13-hydroxyoctadecatrienoic acid and lithocholic acid the contribution of environment to variation was stronger. With increased understanding of lipid mediator functions in health, it is important to understand the factors contributing to their variance. This study provides a comprehensive analysis of lipid mediators and extends pre-existing knowledge of the genetic and environmental influences on the human lipidome., (Copyright © 2021. Published by Elsevier Ltd.)
- Published
- 2021
- Full Text
- View/download PDF
3. Genetic and Environmental Contributions to Variation in the Stable Urinary NMR Metabolome over Time: A Classic Twin Study.
- Author
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Bermingham KM, Brennan L, Segurado R, Barron RE, Gibney ER, Ryan MF, Gibney MJ, and O'Sullivan AM
- Subjects
- Diet, Humans, Magnetic Resonance Spectroscopy, Metabolomics, Gastrointestinal Microbiome, Metabolome
- Abstract
Genes, sex, age, diet, lifestyle, gut microbiome, and multiple other factors affect human metabolomic profiles. Understanding metabolomic variation is critical in human nutrition research as metabolites that are sensitive to change versus those that are more stable might be more informative for a particular study design. This study aims to identify stable metabolomic regions and determine the genetic and environmental contributions to stability. Using a classic twin design,
1 H nuclear magnetic resonance (NMR) urinary metabolomic profiles were measured in 128 twins at baseline, 1 month, and 2 months. Multivariate mixed models identified stable urinary metabolites with intraclass correlation coefficients ≥0.51. Longitudinal twin modeling measured the contribution of genetic and environmental influences to variation in the stable urinary NMR metabolome, comprising stable metabolites. The conservation of an individual's stable urinary NMR metabolome over time was assessed by calculating conservation indices. In this study, 20% of the urinary NMR metabolome is stable over 2 months (intraclass correlation (ICC) 0.51-0.65). Common genetic and shared environmental factors contributed to variance in the stable urinary NMR metabolome over time. Using the stable metabolome, 91% of individuals had good metabolomic conservation indices ≥0.70. To conclude, this research identifies 20% of the urinary NMR metabolome as stable, improves our knowledge of the sources of metabolomic variation over time, and demonstrates the conservation of an individual's urinary NMR metabolome.- Published
- 2021
- Full Text
- View/download PDF
4. Genetic and environmental influences on covariation in reproducible diet-metabolite associations.
- Author
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Bermingham KM, Brennan L, Segurado R, Barron RE, Gibney ER, Ryan MF, Gibney MJ, and O'Sullivan AM
- Subjects
- Adolescent, Adult, Biomarkers urine, Diet, Female, Humans, Male, Middle Aged, Urinalysis, Young Adult, Diet, Healthy, Feeding Behavior, Metabolomics, Twins
- Abstract
Background: Early applications of metabolomics in nutrition and health research identified associations between dietary patterns and metabolomic profiles. Twin studies show that diet-related phenotypes and diet-associated metabolites are influenced by genes. However, studies have not examined whether diet-metabolite associations are explained by genetic or environmental factors and whether these associations are reproducible over multiple time points., Objective: This research aims to examine the genetic and environmental factors influencing covariation in diet-metabolite associations that are reproducible over time in healthy twins., Methods: The UCD Twin Study is a semi-longitudinal classic twin study that collected repeated dietary, anthropometric, and urinary data over 2 months. Correlation analysis identified associations between diet quality measured using the Healthy Eating Index (HEI) and urinary metabolomic profiles at 3 time points. Diet-associated metabolites were examined using linear regression to identify those significantly influenced by familial factors between twins and those significantly influenced by unique factors. Cholesky decomposition modeling quantified the genetic and environmental path coefficients through associated dietary components onto the metabolites., Results: The HEI was associated with 14 urinary metabolites across 3 metabolomic profiles (r: ±0.15-0.49). For 8 diet-metabolite associations, genetic or shared environmental factors influencing HEI component scores significantly influenced variation in metabolites (β: 0.40-0.52). A significant relation was observed between dietary intakes of whole grain and acetoacetate (β: -0.50, P < 0.001) and β-hydroxybutyrate (β: -0.46, P < 0.001), as well as intakes of saturated fat and acetoacetate (β: 0.47, P < 0.001) and β-hydroxybutyrate (β: 0.52, P < 0.001). For these diet-metabolite associations a common shared environmental factor explained 66-69% of variance in the metabolites., Conclusions: This study shows that diet-metabolite associations are reproducible in 3 urinary metabolomic profiles. Components of the HEI covary with metabolites, and covariation is largely due to the shared environment., (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.)
- Published
- 2021
- Full Text
- View/download PDF
5. 3D-printed anatomical models of the cystic duct and its variants, a low-cost solution for an in-house built simulator for laparoscopic surgery training.
- Author
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Casas-Murillo C, Zuñiga-Ruiz A, Lopez-Barron RE, Sanchez-Uresti A, Gogeascoechea-Hernandez A, Muñoz-Maldonado GE, Salinas-Chapa M, Elizondo-Riojas G, and Negreros-Osuna AA
- Subjects
- Cholangiopancreatography, Magnetic Resonance, Cystic Duct diagnostic imaging, Cystic Duct surgery, Humans, Internship and Residency economics, Printing, Three-Dimensional, Simulation Training economics, Surgeons education, Cholecystectomy, Laparoscopic education, Cystic Duct anatomy & histology, Internship and Residency methods, Models, Anatomic, Simulation Training methods
- Abstract
Objectives: To explore a method to create affordable anatomical models of the biliary tree that are adequate for training laparoscopic cholecystectomy with an in-house built simulator., Methods: We used a fused deposition modeling 3D printer to create molds of Acrylonitrile Butadiene Styrene (ABS) from Digital Imaging and Communication on Medicine (DICOM) images, and the molds were filled with silicone rubber. Thirteen surgeons with 4-5-year experience in the procedure evaluated the molds using a low-cost in-house built simulator utilizing a 5-point Likert-type scale., Results: Molds produced through this method had a consistent anatomical appearance and overall realism that evaluators agreed or definitely agreed (4.5/5). Evaluators agreed on recommending the mold for resident surgical training., Conclusions: 3D-printed molds created through this method can be applied to create affordable high-quality educational anatomical models of the biliary tree for training laparoscopic cholecystectomy.
- Published
- 2021
- Full Text
- View/download PDF
6. Exploring Covariation between Traditional Markers of Metabolic Health and the Plasma Metabolomic Profile: A Classic Twin Design.
- Author
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Bermingham KM, Brennan L, Segurado R, Barron RE, Gibney ER, Ryan MF, Gibney MJ, and O'Sullivan AM
- Subjects
- Adult, Anthropometry, Biomarkers metabolism, Chemistry, Clinical methods, Female, Humans, Male, Metabolic Diseases genetics, Metabolic Diseases pathology, Phenotype, Twins, Dizygotic genetics, Twins, Monozygotic genetics, Biomarkers blood, Gene-Environment Interaction, Metabolic Diseases blood, Metabolomics methods
- Abstract
Novel metabolomic profiling techniques combined with traditional biomarkers provide knowledge of mechanisms underlying metabolic health. Twin studies describe the impact of genes and environment on variation in traits. This study aims to identify relationships between traditional markers of metabolic health and the plasma metabolomic profile using a twin modeling approach and determine whether covariation is caused by shared genetic and environmental factors. Using a classic twin design, this study examined covariation between anthropometric, clinical chemistry, and metabolomic profiles. Cholesky decomposition modeling was used to determine the genetic and environmental path coefficients through successive anthropometric and clinical chemistry traits onto metabolomic derived metabolites. This study shows that WC, TAG, and a metabolomic signature composed of 7 metabolites are inter-related, and that covariation can be attributed to common genetic, shared and unique environmental factors as well as unique environmental factors specific to the metabolite. This quantitative modeling connecting the traditional anthropometry and clinical chemistry traits with the more recent and potentially more sensitive metabolomic profile approach may provide further insight on the pleiotropic genes or modifiable environmental factors influencing variation in metabolic health.
- Published
- 2019
- Full Text
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7. Norepinephrine-induced hypertension in Guillain Barré syndrome.
- Author
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Ventura HO, Messerli FH, and Barron RE
- Subjects
- Adult, Catecholamines blood, Female, Hemodynamics, Humans, Polyradiculoneuropathy physiopathology, Hypertension etiology, Norepinephrine blood, Polyradiculoneuropathy complications
- Abstract
Systemic haemodynamics, plasma catecholamine levels and diurnal variation of arterial pressure were studied in a 20-year-old patient with hypertension during Guillain Barré syndrome after complete resolution of the illness. Transient arterial hypertension during the course of Guillain Barré syndrome is characterized by an increased total peripheral resistance associated with elevated circulating norepinephrine levels, suggesting an over-activity of the sympathetic nervous system as the underlying mechanism of the elevated blood pressure.
- Published
- 1986
- Full Text
- View/download PDF
8. Embolic stroke in a woman with mitral valve prolapse who used oral contraceptives.
- Author
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Busch EH, Snyder DW, and Barron RE 3rd
- Subjects
- Adult, Echocardiography, Female, Humans, Intracranial Embolism and Thrombosis diagnostic imaging, Mitral Valve Prolapse diagnosis, Radiography, Risk, Contraceptives, Oral toxicity, Intracranial Embolism and Thrombosis etiology, Mitral Valve Prolapse complications
- Abstract
A case of angiographically-documented embolism is presented in a patient using oral contraceptives (OC) with marked mitral valve prolapse (MVP) and an atrial thrombus. OC use has been shown to decrease levels of antithrombin III and increase platelet coagulant activity. This increased coagulability may increase the risk of intra-atrial thrombus formation and subsequent cerebral embolism in patients with MVP. We believe that MVP, especially when redundant valve leaflets are recognized, may be a relative contraindication to OC use.
- Published
- 1986
- Full Text
- View/download PDF
9. Changes in the hepatic blood vessels in cirrhosis of the liver.
- Author
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CARTER JH, WELCH CS, and BARRON RE
- Subjects
- Humans, Liver Cirrhosis pathology
- Published
- 1961
10. Disorders of gait related to the aging nervous system.
- Author
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Barron RE
- Subjects
- Aged, Apraxias, Humans, Movement Disorders therapy, Muscular Diseases etiology, Posture, Sensory Receptor Cells physiology, Vertigo, Vestibule, Labyrinth physiopathology, Gait, Movement Disorders etiology, Nervous System Diseases complications
- Published
- 1967
11. Recurrent falling spells: differential diagnosis.
- Author
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Soniat TL and Barron RE
- Subjects
- Diagnosis, Differential, Electroencephalography, Epilepsy diagnosis, Humans, Medical History Taking, Seizures diagnosis, Syncope etiology, Syncope diagnosis
- Published
- 1969
- Full Text
- View/download PDF
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