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1. Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size

Author

Duncan, Maggie C., Omondi, F. Harrison, Kinloch, Natalie N., Lapointe, Hope R., Speckmaier, Sarah, Moran-Garcia, Nadia, Lawson, Tanya, DeMarco, Mari L., Simons, Janet, Holmes, Daniel T., Lowe, Christopher F., Bacani, Nic, Sereda, Paul, Barrios, Rolando, Harris, Marianne, Romney, Marc G., Montaner, Julio S.G., Brumme, Chanson J., Brockman, Mark A., and Brumme, Zabrina L.

Published
2024
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10. Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

Author

Brumme, Zabrina L., Mwimanzi, Francis, Lapointe, Hope R., Cheung, Peter K., Sang, Yurou, Duncan, Maggie C., Yaseen, Fatima, Agafitei, Olga, Ennis, Siobhan, Ng, Kurtis, Basra, Simran, Lim, Li Yi, Kalikawe, Rebecca, Speckmaier, Sarah, Moran-Garcia, Nadia, Young, Landon, Ali, Hesham, Ganase, Bruce, Umviligihozo, Gisele, Harrison Omondi, F., Atkinson, Kieran, Sudderuddin, Hanwei, Toy, Junine, Sereda, Paul, Burns, Laura, Costiniuk, Cecilia T., Cooper, Curtis, Anis, Aslam H., Leung, Victor, Holmes, Daniel, DeMarco, Mari L., Simons, Janet, Hedgcock, Malcolm, Romney, Marc G., Barrios, Rolando, Guillemi, Silvia, Brumme, Chanson J., Pantophlet, Ralph, Montaner, Julio S. G., Niikura, Masahiro, Harris, Marianne, Hull, Mark, and Brockman, Mark A.

Published
2022
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11. Access to care and impact on HIV treatment interruptions during the COVID‐19 pandemic among people living with HIV in British Columbia.

Author

Finlayson‐Trick, Emma, Tam, Clara, Wang, Lu, Dawydiuk, Nicole, Salters, Kate, Trigg, Jason, Pakhomova, Tatiana, Marante, Antonio, Sereda, Paul, Wesseling, Tim, Montaner, Julio S. G., Hogg, Robert, Barrios, Rolando, and Moore, David M.

Subjects
HEALTH services accessibility, ANTIRETROVIRAL agents, RESEARCH funding, QUESTIONNAIRES, CONTINUUM of care, JUDGMENT sampling, DESCRIPTIVE statistics, PATIENT care, MULTIVARIATE analysis, PSYCHOLOGY of HIV-positive persons, TELEMEDICINE, ODDS ratio, TREATMENT delay (Medicine), COVID-19 pandemic, PATIENTS' attitudes
Abstract

Introduction: The COVID‐19 pandemic has changed healthcare service delivery. We examined the overall impact of COVID‐19 on people living with HIV in British Columbia (BC), Canada, with a special focus on the potential impact of COVID‐19 on antiretroviral treatment interruptions (TIs). Methods: Purposive sampling was used to enrol people living with HIV aged ≥19 years across BC into the STOP HIV/AIDS Program Evaluation study between January 2016 and September 2018. Participants completed surveys at baseline enrolment and 18 and 36 months later. Additional COVID‐19 questions were added to the survey in October 2020. TIs were defined as >60 days late for antiretroviral therapy (ART) refill using data from the BC HIV Drug Treatment Program. Generalized linear mixed models were used to examine trends in TIs over time and associations with reported health service access. Results: Of 581 participants, 6.1%–7.7% experienced a TI during each 6‐month period between March 2019 and August 2021. The frequency of TIs did not statistically increase during the COVID‐19 epidemic. Among the 188 participants who completed the COVID‐19 questionnaire, 32.8% reported difficulty accessing healthcare during COVID‐19, 9.7% reported avoiding continuing a healthcare service due to COVID‐19‐related concerns, and 74.6% reported using virtual healthcare services since March 2020. In multivariable analysis, the odds of a TI in any 6‐month period were not significantly different from March to August 2019. None of the reported challenges to healthcare services were associated with TIs. Conclusions: Although some participants reported challenges to accessing services or avoidance of services due to COVID‐19, TIs were not more likely during COVID‐19 than before. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Antibody response durability following three-dose coronavirus disease 2019 vaccination in people with HIV receiving suppressive antiretroviral therapy

Author

Lapointe, Hope R., Mwimanzi, Francis, Cheung, Peter K., Sang, Yurou, Yaseen, Fatima, Speckmaier, Sarah, Barad, Evan, Moran-Garcia, Nadia, Datwani, Sneha, Duncan, Maggie C., Kalikawe, Rebecca, Ennis, Siobhan, Young, Landon, Ganase, Bruce, Omondi, F. Harrison, Umviligihozo, Gisele, Dong, Winnie, Toy, Junine, Sereda, Paul, Burns, Laura, Costiniuk, Cecilia T., Cooper, Curtis, Anis, Aslam H., Leung, Victor, Holmes, Daniel, DeMarco, Mari L., Simons, Janet, Hedgcock, Malcolm, Prystajecky, Natalie, Lowe, Christopher F., Romney, Marc G., Barrios, Rolando, Guillemi, Silvia, Brumme, Chanson J., Montaner, Julio S.G., Hull, Mark, Harris, Marianne, Niikura, Masahiro, Brockman, Mark A., and Brumme, Zabrina L.

Published
2023
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13. Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study

Author

Shayegi-Nik, Sara, primary, Honer, William G, additional, Vila-Rodriguez, Fidel, additional, Nanditha, Ni Gusti Ayu, additional, Patterson, Thomas L, additional, Guillemi, Silvia, additional, Nathani, Hasan, additional, Trigg, Jason, additional, Yin, Weijia, additional, Fonseca, Alejandra, additional, T Takeh, Bronhilda, additional, Barrios, Rolando, additional, Montaner, Julio S G, additional, and Lima, Viviane D, additional

Published
2024
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19. Adverse drug reactions attributed to generic substitution of antiretroviral medications among HIV treatment and pre-exposure prophylaxis clients in British Columbia, Canada

Author

Lepik, Katherine J, primary, Hunt, Olivia L, additional, Bacani, Nic, additional, Wang, Lu, additional, Harris, Marianne, additional, Toy, Junine, additional, McLinden, Taylor, additional, Sereda, Paul, additional, Akagi, Linda J, additional, Ready, Erin, additional, Montaner, Julio SG, additional, and Barrios, Rolando, additional

Published
2024
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26. 48-hour Induction of Transdermal Buprenorphine to Extended-release Buprenorphine

Author

Azar, Pouya, primary, Wong, James S.H., additional, Mathew, Nickie, additional, Ignaszewski, Martha J., additional, Partovi, Nilufar, additional, Krausz, Reinhard M., additional, Ajidahun, Adedayo, additional, Thotakura, Sahithi, additional, Harris, Marianne, additional, Barrios, Rolando, additional, Montaner, Julio S.G., additional, and Maharaj, Anil R., additional

Published
2023
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27. Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size

Author

Duncan, Maggie C., primary, Omondi, F. Harrison, additional, Kinloch, Natalie N., additional, Lapointe, Hope R., additional, Speckmaier, Sarah, additional, Moran-Garcia, Nadia, additional, Lawson, Tanya, additional, DeMarco, Mari L., additional, Simons, Janet, additional, Holmes, Daniel T., additional, Lowe, Christopher F., additional, Bacani, Nic, additional, Sereda, Paul, additional, Barrios, Rolando, additional, Harris, Marianne, additional, Romney, Marc G., additional, Montaner, Julio S.G., additional, Brumme, Chanson J., additional, Brockman, Mark A., additional, and Brumme, Zabrina L., additional

Published
2023
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33. Identification of people with low prevalence diseases in administrative healthcare records: A case study of HIV in British Columbia, Canada

Author

Emerson, Scott D., primary, McLinden, Taylor, additional, Sereda, Paul, additional, Lima, Viviane D., additional, Hogg, Robert S., additional, Kooij, Katherine W., additional, Yonkman, Amanda M., additional, Salters, Kate A., additional, Moore, David, additional, Toy, Junine, additional, Wong, Jason, additional, Consolacion, Theodora, additional, Montaner, Julio S. G., additional, and Barrios, Rolando, additional

Published
2023
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36. Evaluating experiences of HIV-related stigma among people living with HIV diagnosed in different treatment eras in British Columbia, Canada.

Author

Tam, Clara, Wang, Lu, Salters, Kate, Moore, David, Wesseling, Tim, Grieve, Sean, Parry, Rebeccah, Barath, Justin, Hogg, Robert, and Barrios, Rolando

Subjects
RESEARCH funding, ANTIRETROVIRAL agents, MENTAL illness, HIV infections, JUDGMENT sampling, MULTIVARIATE analysis, DESCRIPTIVE statistics, EXPERIENCE, PSYCHOLOGY of HIV-positive persons, STATISTICS, COMPARATIVE studies, SOCIAL stigma
Abstract

There is mixed evidence on whether experiences of HIV-related stigma are mitigated with lived experience. We sought to examine whether people living with HIV (PLWH) with longer living experience reported varying levels of HIV-related stigma. Between January 2016-September 2018, we used purposive sampling to enrol PLWH aged ≥19 across British Columbia, Canada, where participants completed the 10-item Berger HIV Stigma Scale. We conducted bivariate analyzes examining key sociodemographic characteristics and HIV-related stigma scores. Multivariable linear regression modelled the association between year of HIV diagnosis by treatment era and HIV-related stigma scores. We enrolled 644 participants; median age at enrolment was 50 years (Q1–Q3: 42–56), with 37.4% (n = 241) diagnosed before the year 2000. The median HIV-stigma scores of all participants (19.0, Q1–Q3: 13–25, range 0–40) stratified by treatment era were: 17.0 (pre-1996), 20.0 (1996–1999), 20.0 (2000–2009), 19.0 (2010–2018) (p = 0.03). While there was a significant association at the univariate level, year of HIV diagnosis by treatment era was not associated with stigma scores after controlling for age, gender, HIV key populations, ethnicity, relationship status, social support, and ever having a mental health disorder diagnosis. This suggests that PLWH still experience HIV-related stigma today, compared to those diagnosed in earlier time periods. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Dynamics of overdose and non-overdose mortality among people living with HIV amidst the illicit drug toxicity crisis in British Columbia.

Author

Yazdani, Kiana, Dhillon, Nalin, Tung, Audrey, Ye, Monica, Trigg, Jason, Stanley, Cole, Ni Gusti Ayu, Nanditha, McLinden, Taylor, Lima, Viviane D., Barrios, Rolando, Hogg, Robert, Montaner, Julio S. G., and Salters, Kate

Subjects
DRUG overdose, DRUG toxicity, SUBSTANCE abuse, RESEARCH funding, SYNDEMICS, CHRONIC pain, T-test (Statistics), HIV-positive persons, HOSPITAL care, FISHER exact test, SEX distribution, CAUSES of death, DESCRIPTIVE statistics, MANN Whitney U Test, CHI-squared test, AGE distribution, STATISTICS, HEPATITIS C, CONFIDENCE intervals, DATA analysis software, DRUGS of abuse, NARCOTIC antagonists
Abstract

We sought to characterize overdose and non-overdose mortality among PLWH amidst the illicit drug toxicity crisis in British Columbia, Canada. A population-based analysis of PLWH (age ≥19) in British Columbia accessing healthcare from April 1996 to March 2017 was conducted using data from the Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) cohort linkage. Underlying causes of deaths were stratified into overdose and non-overdose causes. We compared (bivariate analysis) health-related characteristics and prescription history between PLWH died of overdose and non-overdose causes between April 2009 and March 2017. Among 9,180 PLWH, we observed 962 deaths (142 [14.7%] overdoses; 820 [85.2%] other causes). Compared to those who died from other causes, those who died of overdose were significantly younger (median age [Q, Q3]: 46 years [42, 52] vs. 54 years [48, 63]); had an indication of chronic pain (35.9% vs. 27.1%) and hepatitis C virus (64.8% vs. 50.4%), but fewer experienced hospitalization in the year before death. PLWH who died were most likely to be prescribed with opioids (>50%) and least likely with opioid agonist therapy (<10%) in a year before death. These findings highlight the syndemic of substance use, HCV, and chronic pain, and how the crisis is unqiuely impacting females and younger people. [ABSTRACT FROM AUTHOR]

Published
2024
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38. 48-hour Induction of Transdermal Buprenorphine to Extended-release Buprenorphine.

Author

Azar, Pouya, Wong, James S. H., Mathew, Nickie, Ignaszewski, Martha J., Partovi, Nilufar, Krausz, Reinhard M., Ajidahun, Adedayo, Thotakura, Sahithi, Harris, Marianne, Barrios, Rolando, Montaner, Julio S. G., and Maharaj, Anil R.

Abstract

Buprenorphine extended-release (BUP-XR) provides sustained delivery of buprenorphine to control withdrawal and craving symptoms in the formof a monthly injectable and has been shown to improve health outcomes in patients with opioid use disorder. It is recommended that patients are stabilized with a transmucosal buprenorphine product, for at least 7 days per the product monograph; however, clinically, this timelinemay be expedited. We report a case of a hospitalized patient with unregulated fentanyl use who underwent a successful transdermal buprenorphine induction for 48 hours to initiate BUP-XR with minimal levels of withdrawal and without precipitating opioid withdrawal. The approach described could provide a practical, patient-centered, accelerated induction strategy that, once independently validated, could considerably facilitate the use of BUP-XR. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Depressive Symptoms, the Impact on ART Continuation, and Factors Associated with Symptom Improvement Among a Cohort of People Living with HIV in British Columbia, Canada.

Author

Pakhomova, Tatiana E., Tam, Clara, Wang, Lu, Salters, Kate, Moore, David M., Barath, Justin, Elterman, Simon, Dawydiuk, Nicole, Wesseling, Tim, Grieve, Sean, Sereda, Paul, Hogg, Robert, and Barrios, Rolando

Subjects
MENTAL depression risk factors, HIV-positive persons, CONFIDENCE intervals, SUBSTANCE abuse, MULTIPLE regression analysis, ANTIRETROVIRAL agents, MENTAL health, RISK assessment, SURVEYS, MENTAL depression, QUALITY assurance, DESCRIPTIVE statistics, COCAINE, RESEARCH funding, ODDS ratio, LONGITUDINAL method, HEALTH self-care, EDUCATIONAL attainment, DISEASE complications
Abstract

Depressive symptoms among people living with HIV (PLWH) are associated with poorer overall health outcomes. We characterized depressive symptoms and improvements in symptomology among PLWH (≥ 19 years old) in British Columbia (BC), Canada. We also examined associations between depressive symptomology and antiretroviral therapy (ART) treatment interruptions. Depressive symptoms were measured using the 10-item Center for Epidemiologic Studies Depression Scale (CES-D-10), within a longitudinal cohort study with three surveys administered 18-months apart. We used multivariable logistic regression to model factors associated with improvements in depressive symptoms (CES-D-10 scores from ≥ 10 to < 10). Of the 566 participants eligible for analysis 273 (48.2%) had CES-D scores indicating significant depressive symptoms (score ≥ 10) at enrollment. Improvements in symptoms at first follow-up were associated with greater HIV self-care on the Continuity of Care Scale (adjusted odds ratio: 1.17; 95% CI 1.03–1.32), and not having a previously reported mental health disorder diagnosis (aOR 2.86; 95% CI 1.01–8.13). Those reporting current cocaine use (aOR 0.33; 95% CI 0.12–0.91) and having a high school education, vs. less than, (aOR 0.25; 95% CI 0.08–0.82) had lower odds of improvement in depressive symptomatology. CES-D scores ≥ 10 were not significantly associated with ART treatment interruptions during follow-up (aOR: 1.08; 95% CI:0.65–1.8). Supporting greater self-care and consideration of mental health management strategies in relation to HIV may be useful in promoting the wellbeing of PLWH who experience depressive symptoms. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Informing Targeted Interventions to Optimize the Cascade of HIV Care Using Cluster Analyses of Health Resource Use Among People Living with HIV/AIDS

Author

Krebs, Emanuel, Min, Jeong E., Bayoumi, Ahmed M., Barrios, Rolando, Montaner, Julio S. G., Nosyk, Bohdan, Barrios, Rolando, Daly, Patty, Gustafson, Reka, Kendall, Perry R. W., McGowan, Gina, Day, Irene, Heath, Kate, Hogg, Robert S., Montaner, Julio S. G., Nosyk, Bohdan, and On behalf of the STOP HIV/AIDS Study Group

Published
2017
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43. Exploring Primary Healthcare Experiences and Interest in Mobile Technology Engagement Amongst an Urban Population Experiencing Barriers to Care

Author

Pakhomova, Tatiana E., primary, Nicholson, Valerie, additional, Fischer, Matthew, additional, Ferguson, Joanna, additional, Moore, David M., additional, Salters, Kate, additional, Lester, Richard T., additional, Kremer, Hayden, additional, Dawydiuk, Nicole, additional, Barrios, Rolando, additional, and Parashar, Surita, additional

Published
2023
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44. Dynamics of overdose and non-overdose mortality among people living with HIV amidst the illicit drug toxicity crisis in British Columbia

Author

Yazdani, Kiana, primary, Dhillon, Nalin, additional, Tung, Audrey, additional, Ye, Monica, additional, Trigg, Jason, additional, Stanley, Cole, additional, Ni Gusti Ayu, Nanditha, additional, McLinden, Taylor, additional, Lima, Viviane D., additional, Barrios, Rolando, additional, Hogg, Robert, additional, Montaner, Julio S. G., additional, and Salters, Kate, additional

Published
2023
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45. Process description of developing HIV prevention monitoring indicators for a province-wide pre-exposure prophylaxis (PrEP) program in British Columbia, Canada

Author

Munasinghe, Lalani L., primary, Toy, Junine, additional, Lepik, Katherine J., additional, Moore, David M., additional, Hull, Mark, additional, Bacani, Nic, additional, Sereda, Paul, additional, Barrios, Rolando, additional, Montaner, Julio S. G., additional, and Lima, Viviane D., additional

Published
2023
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48. Identifying Longitudinal CD4:CD8 Ratio Trajectories Indicative of Chronic Renal Disease Risk among People Living with HIV: An Application of Growth Mixture Models

Author

Fonseca-Cuevas, Alejandra, primary, Newsome, Patrick, additional, Wang, Lu, additional, Chen, Michelle Y., additional, Richardson, Chris G., additional, Hull, Mark, additional, McLinden, Taylor, additional, Guillemi, Silvia, additional, Barrios, Rolando, additional, Montaner, Julio S. G., additional, and Lima, Viviane D., additional

Published
2023
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