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Your search keyword '"Barrio‐Alonso, Celia"' showing total 9 results
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9 results on '"Barrio‐Alonso, Celia"'

2. Chemokine profiling of melanoma–macrophage crosstalk identifies CCL8 and CCL15 as prognostic factors in cutaneous melanoma

Author

Barrio‐Alonso, Celia, primary, Nieto‐Valle, Alicia, additional, García‐Martínez, Elena, additional, Gutiérrez‐Seijo, Alba, additional, Parra‐Blanco, Verónica, additional, Márquez‐Rodas, Iván, additional, Avilés‐Izquierdo, José Antonio, additional, Sánchez‐Mateos, Paloma, additional, and Samaniego, Rafael, additional

Published
2024
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4. Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control

Author

Rodriguez-Ruiz, Maria E, primary, Serrano-Mendioroz, Irantzu, additional, Garate-Soraluze, Eneko, additional, Sánchez-Mateos, Paloma, additional, Barrio-Alonso, Celia, additional, Rodríguez López, Inmaculada, additional, Diaz Pascual, Victor, additional, Arbea Moreno, Leire, additional, Alvarez, Maite, additional, Sanmamed, Miguel F, additional, Perez-Gracia, Jose Luis, additional, Escuin-Ordinas, Helena, additional, Quintero, Marisol, additional, and Melero, Ignacio, additional

Published
2023
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5. ICAP‐1 loss impairs CD8 + thymocyte development and leads to reduced marginal zone B cells in mice

Author

Sevilla‐Movilla, Silvia, primary, Fuentes, Patricia, additional, Rodríguez‐García, Yaiza, additional, Arellano‐Sánchez, Nohemi, additional, Krenn, Peter W., additional, de Val, Soledad Isern, additional, Montero‐Herradón, Sara, additional, García‐Ceca, Javier, additional, Burdiel‐Herencia, Valeria, additional, Gardeta, Sofía R., additional, Aguilera‐Montilla, Noemí, additional, Barrio‐Alonso, Celia, additional, Crainiciuc, Georgiana, additional, Bouvard, Daniel, additional, García‐Pardo, Angeles, additional, Zapata, Agustin G., additional, Hidalgo, Andrés, additional, Fässler, Reinhard, additional, Carrasco, Yolanda R., additional, Toribio, Maria L., additional, and Teixidó, Joaquin, additional

Published
2022
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6. The Macrophage Reprogramming Ability of Antifolates Reveals Soluble CD14 as a Potential Biomarker for Methotrexate Response in Rheumatoid Arthritis

Author

Fuentelsaz-Romero, Sara, primary, Barrio-Alonso, Celia, additional, García Campos, Raquel, additional, Torres Torresano, Mónica, additional, Muller, Ittai B., additional, Triguero-Martínez, Ana, additional, Nuño, Laura, additional, Villalba, Alejandro, additional, García-Vicuña, Rosario, additional, Jansen, Gerrit, additional, Miranda-Carús, María-Eugenia, additional, González-Álvaro, Isidoro, additional, and Puig-Kröger, Amaya, additional

Published
2021
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7. CCL20/TNF/VEGFA Cytokine Secretory Phenotype of Tumor-Associated Macrophages Is a Negative Prognostic Factor in Cutaneous Melanoma

Author

Gutiérrez-Seijo, Alba, primary, García-Martínez, Elena, additional, Barrio-Alonso, Celia, additional, Pareja-Malagón, Miriam, additional, Acosta-Ocampo, Alejandra, additional, Fernández-Santos, María Eugenia, additional, Puig-Kröger, Amaya, additional, Parra-Blanco, Verónica, additional, Mercader, Enrique, additional, Márquez-Rodas, Iván, additional, Avilés-Izquierdo, José Antonio, additional, Samaniego, Rafael, additional, and Sánchez-Mateos, Paloma, additional

Published
2021
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8. ICAP‐1 loss impairs CD8+ thymocyte development and leads to reduced marginal zone B cells in mice.

Author

Sevilla‐Movilla, Silvia, Fuentes, Patricia, Rodríguez‐García, Yaiza, Arellano‐Sánchez, Nohemi, Krenn, Peter W., de Val, Soledad Isern, Montero‐Herradón, Sara, García‐Ceca, Javier, Burdiel‐Herencia, Valeria, Gardeta, Sofía R., Aguilera‐Montilla, Noemí, Barrio‐Alonso, Celia, Crainiciuc, Georgiana, Bouvard, Daniel, García‐Pardo, Angeles, Zapata, Agustin G., Hidalgo, Andrés, Fässler, Reinhard, Carrasco, Yolanda R., and Toribio, Maria L.

Subjects
B cells, CELL physiology, CELL adhesion, TRANSCRIPTION factors, THYMOCYTES
Abstract

ICAP‐1 regulates β1‐integrin activation and cell adhesion. Here, we used ICAP‐1‐null mice to study ICAP‐1 potential involvement during immune cell development and function. Integrin α4β1‐dependent adhesion was comparable between ICAP‐1‐null and control thymocytes, but lack of ICAP‐1 caused a defective single‐positive (SP) CD8+ cell generation, thus, unveiling an ICAP‐1 involvement in SP thymocyte development. ICAP‐1 bears a nuclear localization signal and we found it displayed a strong nuclear distribution in thymocytes. Interestingly, there was a direct correlation between the lack of ICAP‐1 and reduced levels in SP CD8+ thymocytes of Runx3, a transcription factor required for CD8+ thymocyte generation. In the spleen, ICAP‐1 was found evenly distributed between cytoplasm and nuclear fractions, and ICAP‐1–/– spleen T and B cells displayed upregulation of α4β1‐mediated adhesion, indicating that ICAP‐1 negatively controls their attachment. Furthermore, CD3+‐ and CD19+‐selected spleen cells from ICAP‐1‐null mice showed reduced proliferation in response to T‐ and B‐cell stimuli, respectively. Finally, loss of ICAP‐1 caused a remarkable decrease in marginal zone B‐ cell frequencies and a moderate increase in follicular B cells. Together, these data unravel an ICAP‐1 involvement in the generation of SP CD8+ thymocytes and in the control of marginal zone B‐cell numbers. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Activin A Sustains the Metastatic Phenotype of Tumor-Associated Macrophages and Is a Prognostic Marker in Human Cutaneous Melanoma

Author

Gutiérrez-Seijo, Alba, García-Martínez, Elena, Barrio-Alonso, Celia, Parra-Blanco, Verónica, Avilés-Izquierdo, José Antonio, Sánchez-Mateos, Paloma, and Samaniego, Rafael

Abstract

Tumor cells attract and dynamically interact with monocytes/macrophages to subvert their differentiation into tumor-associated macrophages (TAMs), which mainly promote immune suppression and neoplastic progression, but the pathways and microenvironmental cues governing their protumoral deviation are not completely understood. To identify the molecular pathways responsible for TAM differentiation, we screened the biomarkers secreted during melanoma‒macrophage interactions using Quantibody microarrays and RNA sequencing of macrophages. We found that activin A, a member of the transforming GF family, plays an instrumental role in the cross-talk between melanoma cells and monocytes/macrophages, which results in the upregulation of distinct tumor-sustaining genes and the achievement of proinvasive and immunosuppressive functions of TAMs. Blockade of activin reduces the upregulation of part of these genes and prevents the acquisition of protumoral functions, facilitating human melanoma rejection by transferred human lymphocytes in a xenograft mouse model. Remarkably, screening of two independent cutaneous primary melanoma collections showed that activin A is enriched in TAMs and melanoma cells from patients with worse outcomes and constitutes a new and independent prognostic marker. Thus, we identify activin A as a key intermediary in the protumoral and immunosuppressive functions of TAMs, with significant potential as a disease biomarker as well as an immunotherapeutic target.

Published
2021
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