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3. Sensitivity of Alabama Freshwater Gastropod Species to Nickel Exposure.

Author

Barrick, Andrew, Parham, Sean, Johnson, Paul, Brewer, Shannon, and Hoang, Tham

Subjects
*FRESHWATER snails, *ENDEMIC species, *HAZARDOUS substances, *ECOLOGICAL niche, *PUBLIC domain (Copyright law)
Abstract

Snails are effective bioindicators due to their prolific distribution, high level of endemism, and capacity to accumulate contaminants. Freshwater snails have unique ecological niches which are imperiled by land‐use change and the introduction of hazardous chemicals. To assess how environmental alterations affect gastropods, lab‐based studies are needed to characterize the toxicity of specific stressors. This can help guide policy decisions and remediation efforts. The aim of this research was to characterize acute toxicity of nickel (Ni) on endemic snails (Somatogyrus georgianus [Walker, 1904], Elimia cahawbensis [Lea, 1861], and Elimia spp.) and measure the accumulation of Ni and mineral elements including calcium (Ca), magnesium, potassium, and sodium (Na). Snails were exposed to six concentrations (25–800 µg/L) of Ni for 96 h. Among the studied snail species, E. cahawbensis was the most sensitive to Ni, with the lowest lethal concentration where 50% of the organisms died (LC50) at 88.88 µg/L Ni after 96 h. The LC50 at 96 h for S. georgianus was 167.78 µg/L Ni, and 393.13 μg/L Ni for Elimia spp. Except for Elimia spp., mortality of the other two snail species corresponded to the whole‐body uptake of Ni. Nickel exposure also influenced Ca and Na uptake for Elimia spp. All three endemic species are potential candidate species for evaluating localized effects of human activities, and the present study provides a first step in characterizing how snails would be affected by environmental alterations. More research could further characterize potential effects of other human stressors on these endemic snail species. Future research into subindividual responses and routes of exposure can further elucidate variations in species sensitivity. Environ Toxicol Chem 2024;43:2578–2588. © 2024 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Towards FAIR nanosafety data

Author

Jeliazkova, Nina, Apostolova, Margarita D., Andreoli, Cristina, Barone, Flavia, Barrick, Andrew, Battistelli, Chiara, Bossa, Cecilia, Botea-Petcu, Alina, Châtel, Amélie, De Angelis, Isabella, Dusinska, Maria, El Yamani, Naouale, Gheorghe, Daniela, Giusti, Anna, Gómez-Fernández, Paloma, Grafström, Roland, Gromelski, Maciej, Jacobsen, Nicklas Raun, Jeliazkov, Vedrin, Jensen, Keld Alstrup, Kochev, Nikolay, Kohonen, Pekka, Manier, Nicolas, Mariussen, Espen, Mech, Agnieszka, Navas, José María, Paskaleva, Vesselina, Precupas, Aurica, Puzyn, Tomasz, Rasmussen, Kirsten, Ritchie, Peter, Llopis, Isabel Rodríguez, Rundén-Pran, Elise, Sandu, Romica, Shandilya, Neeraj, Tanasescu, Speranta, Haase, Andrea, and Nymark, Penny

Published
2021
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7. Development and validation of molecular biomarkers for the green-lipped mussel (Perna canaliculus).

Author

Baettig, Camille G., Barrick, Andrew, Zirngibl, Martin, Lear, Gavin, Smith, Kirsty F., Northcott, Grant L., and Tremblay, Louis A.

Subjects
*MARINE ecosystem health, *CHEMICAL testing, *REVERSE transcriptase polymerase chain reaction, *COASTAL ecosystem health, *AGRICULTURE, *ENDOCRINE disruptors
Abstract

Globally, there is a move towards using local, native species for ecotoxicological risk assessments. Anthropogenic stressors from urban, agricultural, and industrial activities can impact the health of receiving ecosystems. Biomarkers can provide valuable insights as early warning signals of the potential environmental impacts of stressors. The aim of this study was to develop biomarkers in the green-lipped mussel (Perna canaliculus), a potential bioindicator of environmental health for coastal marine ecosystems in New Zealand. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) assays targeting the expression of genes involved in oxidative stress, xenobiotic transfer, membrane transportation, cellular and DNA response/repair, and endocrine disruption were developed and validated for P. canaliculus. We found significant modulation of genes associated with oxidative stress, xenobiotic transfer, membrane transport, endocrine disruption, and genotoxicity in P. canaliculus following 48-hour exposures to copper and benzo[α]pyrene. These results demonstrate the potential of P. canaliculus as a bioindicator species for environmental risk assessment. The gene expression assays showed potential as early indicators of exposure to the chemicals tested but require additional validation to assess their ability to predict effects at higher levels of biological organisation. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Safe(r) by design implementation in the nanotechnology industry

Author

Sánchez Jiménez, Araceli, Puelles, Raquel, Pérez-Fernández, Marta, Gómez-Fernández, Paloma, Barruetabeña, Leire, Jacobsen, Nicklas Raun, Suarez-Merino, Blanca, Micheletti, Christian, Manier, Nicolas, Trouiller, Bénédicte, Navas, Jose Maria, Kalman, Judit, Salieri, Beatrice, Hischier, Roland, Handzhiyski, Yordan, Apostolova, Margarita D., Hadrup, Niels, Bouillard, Jacques, Oudart, Yohan, Merino, Cesar, Garcia, Erika, Liguori, Biase, Sabella, Stefania, Rose, Jerome, Masion, Armand, Galea, Karen S., Kelly, Sean, Štěpánková, Sandra, Mouneyrac, Catherine, Barrick, Andrew, Châtel, Amélie, Dusinska, María, Rundén-Pran, Elise, Mariussen, Espen, Bressot, Christophe, Aguerre-Chariol, Olivier, Shandilya, Neeraj, Goede, Henk, Gomez-Cordon, Julio, Simar, Sophie, Nesslany, Fabrice, Jensen, Keld Alstrup, van Tongeren, Martie, and Rodríguez Llopis, Isabel

Published
2020
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13. Development and validation of molecular biomarkers for the green-lipped mussel (Perna canaliculus)

Author

Baettig, Camille G., Barrick, Andrew, Zirngibl, Martin, Lear, Gavin, Smith, Kirsty F., Northcott, Grant L., and Tremblay, Louis A.

Abstract

Globally, there is a move towards using local, native species for ecotoxicological risk assessments. Anthropogenic stressors from urban, agricultural, and industrial activities can impact the health of receiving ecosystems. Biomarkers can provide valuable insights as early warning signals of the potential environmental impacts of stressors. The aim of this study was to develop biomarkers in the green-lipped mussel (Perna canaliculus), a potential bioindicator of environmental health for coastal marine ecosystems in New Zealand. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) assays targeting the expression of genes involved in oxidative stress, xenobiotic transfer, membrane transportation, cellular and DNA response/repair, and endocrine disruption were developed and validated for P. canaliculus. We found significant modulation of genes associated with oxidative stress, xenobiotic transfer, membrane transport, endocrine disruption, and genotoxicity in P. canaliculus following 48-hour exposures to copper and benzo[α]pyrene. These results demonstrate the potential of P. canaliculus as a bioindicator species for environmental risk assessment. The gene expression assays showed potential as early indicators of exposure to the chemicals tested but require additional validation to assess their ability to predict effects at higher levels of biological organisation.

Published
2023
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14. Towards FAIR nanosafety data

Author

European Commission, Jeliazkova, Nina [0000-0002-4322-6179], Apostolova, Margarita D. [0000-0001-7188-506X], Andreoli, Cristina [0000-0003-3724-0668], Barone, Flavia [0000-0002-8929-7749], Barrick, Andrew [0000-0002-2653-2780], Battistelli, Chiara [0000-0003-2386-0727], Bossa, Cecilia [0000-0003-2084-2902], Châtel, Amélie [0000-0003-2245-0216], De Angelis, Isabella [0000-0001-7820-3631], Dusinska, Maria [0000-0003-1358-1652], El Yamani, Naouale [0000-0001-5456-8230], Gheorghe, Daniela [0000-0002-3835-7318], Giusti, Anna [0000-0002-5027-2069], Gómez-Fernández, Paloma [0000-0002-2086-0652], Jeliazkov, Vedrin [0000-0002-1520-5995], Jensen, Keld Alstrup [0000-0002-2764-3634], Gromelski, Maciej [0000-0001-5185-8208], Jacobsen, Nicklas Raun [0000-0002-2504-2229], Kochev, Nikolay [0000-0001-6547-3675], Kohonen, Pekka [0000-0002-7845-3611], Manier, Nicolas [0000-0003-3873-6657], Mariussen, Espen [0000-0001-5150-942X], Navas Antón, José María [0000-0002-7644-8499], Paskaleva, Vesselina [0000-0002-0560-4511], Precupas, Aurica [0000-0002-2381-7617], Puzyn, Tomasz [0000-0003-0449-8339], Llopis, Isabel Rodríguez [0000-0003-1514-4800], Rundén-Pran, Elise [0000-0002-5541-4513], Sandu, Romica [0000-0003-3449-5905], Shandilya, Neeraj [0000-0003-3328-8517], Tanasescu, Speranta [0000-0002-4326-1839], Nymark, Penny [0000-0002-3435-7775], Jeliazkova, Nina, Apostolova, Margarita D, Andreoli, Cristina, Barone, Flavia, Barrick, Andrew, Battistelli, Chiara, Bossa, Cecilia, Botea-Petcu, Alina, Châtel, Amélie, De Angelis, Isabella, Dusinska, Maria, El Yamani, Naouale, Gheorghe, Daniela, Giusti, Anna, Gómez-Fernández, Paloma, Gromelski, Maciej, Jacobsen, Nicklas Raun, Jeliazkov, Vedrin, Jensen, Keld Alstrup, Kochev, Nikolay, Kohonen, Pekka, Manier, Nicolas, Mariussen, Espen, Mech, Agnieszka, Navas Antón, José María, Paskaleva, Vesselina, Precupas, Aurica, Puzyn, Tomasz, Rasmussen, Kirsten, Ritchie, Peter, Llopis, Isabel Rodríguez, Rundén-Pran, Elise, Sandu, Romica, Shandilya, Neeraj, Tanasescu, Speranta, Haase, Andrea, Nymark, Penny, European Commission, Jeliazkova, Nina [0000-0002-4322-6179], Apostolova, Margarita D. [0000-0001-7188-506X], Andreoli, Cristina [0000-0003-3724-0668], Barone, Flavia [0000-0002-8929-7749], Barrick, Andrew [0000-0002-2653-2780], Battistelli, Chiara [0000-0003-2386-0727], Bossa, Cecilia [0000-0003-2084-2902], Châtel, Amélie [0000-0003-2245-0216], De Angelis, Isabella [0000-0001-7820-3631], Dusinska, Maria [0000-0003-1358-1652], El Yamani, Naouale [0000-0001-5456-8230], Gheorghe, Daniela [0000-0002-3835-7318], Giusti, Anna [0000-0002-5027-2069], Gómez-Fernández, Paloma [0000-0002-2086-0652], Jeliazkov, Vedrin [0000-0002-1520-5995], Jensen, Keld Alstrup [0000-0002-2764-3634], Gromelski, Maciej [0000-0001-5185-8208], Jacobsen, Nicklas Raun [0000-0002-2504-2229], Kochev, Nikolay [0000-0001-6547-3675], Kohonen, Pekka [0000-0002-7845-3611], Manier, Nicolas [0000-0003-3873-6657], Mariussen, Espen [0000-0001-5150-942X], Navas Antón, José María [0000-0002-7644-8499], Paskaleva, Vesselina [0000-0002-0560-4511], Precupas, Aurica [0000-0002-2381-7617], Puzyn, Tomasz [0000-0003-0449-8339], Llopis, Isabel Rodríguez [0000-0003-1514-4800], Rundén-Pran, Elise [0000-0002-5541-4513], Sandu, Romica [0000-0003-3449-5905], Shandilya, Neeraj [0000-0003-3328-8517], Tanasescu, Speranta [0000-0002-4326-1839], Nymark, Penny [0000-0002-3435-7775], Jeliazkova, Nina, Apostolova, Margarita D, Andreoli, Cristina, Barone, Flavia, Barrick, Andrew, Battistelli, Chiara, Bossa, Cecilia, Botea-Petcu, Alina, Châtel, Amélie, De Angelis, Isabella, Dusinska, Maria, El Yamani, Naouale, Gheorghe, Daniela, Giusti, Anna, Gómez-Fernández, Paloma, Gromelski, Maciej, Jacobsen, Nicklas Raun, Jeliazkov, Vedrin, Jensen, Keld Alstrup, Kochev, Nikolay, Kohonen, Pekka, Manier, Nicolas, Mariussen, Espen, Mech, Agnieszka, Navas Antón, José María, Paskaleva, Vesselina, Precupas, Aurica, Puzyn, Tomasz, Rasmussen, Kirsten, Ritchie, Peter, Llopis, Isabel Rodríguez, Rundén-Pran, Elise, Sandu, Romica, Shandilya, Neeraj, Tanasescu, Speranta, Haase, Andrea, and Nymark, Penny

Abstract

Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have investigated environmental and health safety aspects of nanomaterials, but the reuse of accumulated data is clearly lagging behind. Here we summarize challenges and provide recommendations for the efficient reuse of nanosafety data, in line with the recently established FAIR (findable, accessible, interoperable and reusable) guiding principles. We describe the FAIR-aligned Nanosafety Data Interface, with an aggregated findability, accessibility and interoperability across physicochemical, bio-nano interaction, human toxicity, omics, ecotoxicological and exposure data. Overall, we illustrate a much-needed path towards standards for the optimized use of existing data, which avoids duplication of efforts, and provides a multitude of options to promote safe and sustainable nanotechnology.

Published
2021

15. Safe(r) by design implementation in the nanotechnology industry

Author

European Commission, Sánchez-Jiménez, A. [0000-0002-2625-9155], Puelles, Raquel [0000-0002-7185-2177], Pérez-Fernández, Marta [0000-0002-8522-6679], Gómez-Fernández, Paloma [0000-0002-2086-0652], Barruetabeña, Leire [0000-0003-4648-9959], Jacobsen, Nicklas Raun [0000-0002-2504-2229], Suarez-Merino, Blanca [0000-0002-0201-265X], Manier, Nicolas [0000-0003-3873-6657], Trouiller, Bénédicte [0000-0003-4367-2870], Navas Antón, José María [0000-0002-7644-8499], Kalman, Judit [0000-0002-3610-1968], Salieri, Beatrice [0000-0002-8338-6206], Hischier, Roland [0000-0002-1084-7665], Handzhiyski, Yordan [0000-0002-8248-0524], Apostolova, Margarita D [0000-0001-7188-506X], Hadrup, Niels [0000-0002-1188-445X], Oudart, Yohan [0000-0001-9790-0766], Merino, Cesar [0000-0002-1414-2208], Liguori, Biase [0000-0001-9531-7796], Sabella, Stefania [0000-0003-3353-3607], Rose, Jerome [0000-0003-3071-8147], Galea, Karen S. [0000-0002-9540-8513], Stepankova, Sandra [0000-0002-9730-7302], Mouneyrac, Catherine [0000-0003-3769-0386], Barrick, Andrew [0000-0002-2653-2780], Châtel, Amélie [0000-0003-2245-0216], Dusinska, Maria [0000-0003-1358-1652], Rundén-Pran, Elise [0000-0002-5541-4513], Mariussen, Espen [0000-0001-5150-942X], Bressot, Christophe [0000-0002-3649-0596], Aguerre-Chariol, Olivier [0000-0001-9488-9530], Shandilya, Neeraj [0000-0003-3328-8517], Gomez-Cordon, Julio [0000-0002-6749-4354], Simar, Sophie [0000-0002-9144-5149], Nesslany, Fabrice [0000-0003-2846-1442], Jensen, Keld Alstrup [0000-0002-2764-3634], van Tongeren, Martie [0000-0002-1205-1898], Rodríguez Llopis, Isabel [0000-0003-1514-4800], Sánchez-Jiménez, A., Puelles, Raquel, Pérez-Fernández, Marta, Gómez-Fernández, Paloma, Barruetabeña, Leire, Jacobsen, Nicklas Raun, Suarez-Merino, Blanca, Micheletti, Christian, Manier, Nicolas, Trouiller, Bénédicte, Navas Antón, José María, Kalman, Judit, Salieri, Beatrice, Hischier, Roland, Handzhiyski, Yordan, Apostolova, Margarita D, Hadrup, Niels, Bouillard, Jacques, Oudart, Yohan, Merino, Cesar, Garcia, Erika, Liguori, Biase, Sabella, Stefania, Rose, Jerome, Masion, Armand, Galea, Karen S., Kelly, Sean, Stepankova, Sandra, Mouneyrac, Catherine, Barrick, Andrew, Châtel, Amélie, Dusinska, Maria, Rundén-Pran, Elise, Mariussen, Espen, Bressot, Christophe, Aguerre-Chariol, Olivier, Shandilya, Neeraj, Goede, Henk, Gomez-Cordon, Julio, Simar, Sophie, Nesslany, Fabrice, Jensen, Keld Alstrup, van Tongeren, Martie, Rodríguez Llopis, Isabel, European Commission, Sánchez-Jiménez, A. [0000-0002-2625-9155], Puelles, Raquel [0000-0002-7185-2177], Pérez-Fernández, Marta [0000-0002-8522-6679], Gómez-Fernández, Paloma [0000-0002-2086-0652], Barruetabeña, Leire [0000-0003-4648-9959], Jacobsen, Nicklas Raun [0000-0002-2504-2229], Suarez-Merino, Blanca [0000-0002-0201-265X], Manier, Nicolas [0000-0003-3873-6657], Trouiller, Bénédicte [0000-0003-4367-2870], Navas Antón, José María [0000-0002-7644-8499], Kalman, Judit [0000-0002-3610-1968], Salieri, Beatrice [0000-0002-8338-6206], Hischier, Roland [0000-0002-1084-7665], Handzhiyski, Yordan [0000-0002-8248-0524], Apostolova, Margarita D [0000-0001-7188-506X], Hadrup, Niels [0000-0002-1188-445X], Oudart, Yohan [0000-0001-9790-0766], Merino, Cesar [0000-0002-1414-2208], Liguori, Biase [0000-0001-9531-7796], Sabella, Stefania [0000-0003-3353-3607], Rose, Jerome [0000-0003-3071-8147], Galea, Karen S. [0000-0002-9540-8513], Stepankova, Sandra [0000-0002-9730-7302], Mouneyrac, Catherine [0000-0003-3769-0386], Barrick, Andrew [0000-0002-2653-2780], Châtel, Amélie [0000-0003-2245-0216], Dusinska, Maria [0000-0003-1358-1652], Rundén-Pran, Elise [0000-0002-5541-4513], Mariussen, Espen [0000-0001-5150-942X], Bressot, Christophe [0000-0002-3649-0596], Aguerre-Chariol, Olivier [0000-0001-9488-9530], Shandilya, Neeraj [0000-0003-3328-8517], Gomez-Cordon, Julio [0000-0002-6749-4354], Simar, Sophie [0000-0002-9144-5149], Nesslany, Fabrice [0000-0003-2846-1442], Jensen, Keld Alstrup [0000-0002-2764-3634], van Tongeren, Martie [0000-0002-1205-1898], Rodríguez Llopis, Isabel [0000-0003-1514-4800], Sánchez-Jiménez, A., Puelles, Raquel, Pérez-Fernández, Marta, Gómez-Fernández, Paloma, Barruetabeña, Leire, Jacobsen, Nicklas Raun, Suarez-Merino, Blanca, Micheletti, Christian, Manier, Nicolas, Trouiller, Bénédicte, Navas Antón, José María, Kalman, Judit, Salieri, Beatrice, Hischier, Roland, Handzhiyski, Yordan, Apostolova, Margarita D, Hadrup, Niels, Bouillard, Jacques, Oudart, Yohan, Merino, Cesar, Garcia, Erika, Liguori, Biase, Sabella, Stefania, Rose, Jerome, Masion, Armand, Galea, Karen S., Kelly, Sean, Stepankova, Sandra, Mouneyrac, Catherine, Barrick, Andrew, Châtel, Amélie, Dusinska, Maria, Rundén-Pran, Elise, Mariussen, Espen, Bressot, Christophe, Aguerre-Chariol, Olivier, Shandilya, Neeraj, Goede, Henk, Gomez-Cordon, Julio, Simar, Sophie, Nesslany, Fabrice, Jensen, Keld Alstrup, van Tongeren, Martie, and Rodríguez Llopis, Isabel

Abstract

The implementation of Safe(r) by Design (SbD) in industrial innovations requires an integrated approach where the human, environmental and economic impact of the SbD measures is evaluated across and throughout the nanomaterial (NM) life cycle. SbD was implemented in six industrial companies where SbD measures were applied to NMs, nano-enabled products (NEPs) and NM/NEP manufacturing processes. The approach considers human and environmental risks, functionality of the NM/NEP and costs as early as possible in the innovation process, continuing throughout the innovation progresses. Based on the results of the evaluation, a decision has to be made on whether to continue, stop or re-design the NM/NEP/process or to carry out further tests/obtain further data in cases where the uncertainty of the human and environmental risks is too large. However, SbD can also be implemented at later stages when there is already a prototype product or process available, as demonstrated in some of the cases. The SbD measures implemented in some of the case studies did not result in a viable solution. For example the coating of silicon nanoparticles with amorphous carbon increased the conductivity, the stability and reduced the dustiness of the particles and therefore the risk of explosion and the exposure to workers. However the socioeconomic assessment for their use in lithium-ion batteries for cars, when compared to the use of graphite, showed that the increase in performance did not overcome the higher production costs. This work illustrates the complexities of selecting the most appropriate SbD measures and highlights that SbD cannot be solely based on a hazard and exposure assessment but must include other impacts that any SbD measures may have on sustainability including energy consumption and waste generation as well as all associated monetary costs.

Published
2020

17. Implementation of the Grouping and Read-Across Approach for the Prediction of Nanomaterials Ecotoxicity

Author

Gromelski, Maciej, primary, Rybińska-Fryca, Anna, additional, Vijver, Martina G., additional, Peijnenburg, Willie, additional, Chatel, Amelie, additional, Barrick, Andrew, additional, Manier, Nicolas, additional, Kalman, Judit, additional, Navas, José Maria, additional, Stępnik, Maciej, additional, Buławska, Natalia, additional, Sosnowska, Anita, additional, Mikołajczyk, Alicja, additional, Jagiełło, Karolina, additional, and Puzyn, Tomasz, additional

Published
2022
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22. Induction of metallothionein in the common bully (Gobiomorphus cotidianus) from the Motueka River.

Author

Tremblay, Louis A., Trought, Katherine, Sheehan, Thomas J., Holmes, Robin J. P., Barrick, Andrew, and Young, Roger G.

Subjects
TRACE metals, METALLOTHIONEIN, RIVER sediments, BULLYING, WATER quality
Abstract

The Motueka catchment is a major river system in the South Island, New Zealand, typically considered to be of 'good water quality'. The catchment has high metal inputs originating from a mineral belt in the headwaters. This study investigated the induction of metallothionein (MT) in the common bully, Gobiomorphus cotidianus, to assess exposure to trace metal contamination in the Motueka River. The results showed a significant increase in MT induction in both the gill and liver tissue samples from fish collected in the Motueka River compared to a reference site in the Brooklyn Stream tributary. This effect is likely modulated by the higher nickel levels originating from the Red Hills that accumulated in the sediment of the Motueka River. [ABSTRACT FROM AUTHOR]

Published
2021
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25. The role of high-throughput screening in ecotoxicology and engineered nanomaterials

Author

Barrick, Andrew, Châtel, Amélie, Bruneau, Mélanie, and Mouneyrac, Catherine

Subjects
Phytoplankton, Toxicity Tests, Fishes, Animals, Quantitative Structure-Activity Relationship, Invertebrates, High-Throughput Screening Assays, Nanostructures
Abstract

The field of environmental toxicology developed as a result of growing concerns about anthropogenic influences on the environment and how to ameliorate ecological impact. Many governmental bodies are beginning to emphasize prevention rather than mitigation when addressing novel products, leading to more of a focus on identifying potential toxicity prior to release. With the exponential advances in their development and sale, novel metamaterials and biotechnology are set to dramatically outpace the capabilities of current testing strategies. To address the need for a fast, cost-effective means of testing chemicals, high-throughput screening (HTS) is currently being used in toxicology and being adapted to ecotoxicology in projects such as ToxCast and Tox21. Despite the growth of research using HTS platforms, its role in ecotoxicology is still uncertain, particularly in how it should be applied in regulation. The aim of the present review is to discuss common test strategies used in designing HTS platforms, the current potential applications for ecotoxicological research, its role in regulatory policies, and its ability to address growing concerns such as engineered nanomaterials. Environ Toxicol Chem 2017;36:1704-1714. © 2017 SETAC.

Published
2017
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26. Towards FAIR nanosafety data

Author

Vesselina Paskaleva, Nicolas Manier, Vedrin Jeliazkov, Penny Nymark, Keld Alstrup Jensen, Peter Ritchie, Maria Dusinska, Nicklas Raun Jacobsen, Pekka Kohonen, Margarita D. Apostolova, Nikolay Kochev, Elise Rundén-Pran, Isabel Rodríguez Llopis, Agnieszka Mech, Naouale El Yamani, Andrea Haase, Cristina Andreoli, Isabella De Angelis, Speranta Tanasescu, Aurica Precupas, Flavia Barone, Chiara Laura Battistelli, Kirsten Rasmussen, Tomasz Puzyn, José María Navas, Roland C. Grafström, Daniela Gheorghe, Cecilia Bossa, Maciej Gromelski, Paloma Gómez-Fernández, Espen Mariussen, Alina Botea-Petcu, Anna Giusti, Andrew Barrick, Romica Sandu, Neeraj Shandilya, Nina Jeliazkova, Amélie Châtel, European Commission, Jeliazkova, Nina, Apostolova, Margarita D., Andreoli, Cristina, Barone, Flavia, Barrick, Andrew, Battistelli, Chiara, Bossa, Cecilia, Châtel, Amélie, De Angelis, Isabella, Dusinska, Maria, El Yamani, Naouale, Gheorghe, Daniela, Giusti, Anna, Gómez-Fernández, Paloma, Jeliazkov, Vedrin, Jensen, Keld Alstrup, Gromelski, Maciej, Jacobsen, Nicklas Raun, Kochev, Nikolay, Kohonen, Pekka, Manier, Nicolas, Mariussen, Espen, Navas, José María, Paskaleva, Vesselina, Precupas, Aurica, Puzyn, Tomasz, Llopis, Isabel Rodríguez, Rundén-Pran, Elise, Sandu, Romica, Shandilya, Neeraj, Tanasescu, Speranta, Nymark, Penny, Institut National de l'Environnement Industriel et des Risques (INERIS), and The Netherlands Organisation for Applied Scientific Research (TNO)

Subjects
Human toxicity, Guiding Principles, Computer science, Global investments, Interoperability, Biomedical Engineering, Bioengineering, 02 engineering and technology, Reuse, 010402 general chemistry, Collaborative projects, Ecotoxicological, 01 natural sciences, Sustainable nanotechnologies, Enabling technologies, General Materials Science, Electrical and Electronic Engineering, Lagging, 9. Industry and infrastructure, Guiding principles, Findability, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Data science, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, [SDE]Environmental Sciences, Key (cryptography), Data interfaces, 0210 nano-technology, Exposure data
Abstract

13 Pág. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have investigated environmental and health safety aspects of nanomaterials, but the reuse of accumulated data is clearly lagging behind. Here we summarize challenges and provide recommendations for the efficient reuse of nanosafety data, in line with the recently established FAIR (findable, accessible, interoperable and reusable) guiding principles. We describe the FAIR-aligned Nanosafety Data Interface, with an aggregated findability, accessibility and interoperability across physicochemical, bio-nano interaction, human toxicity, omics, ecotoxicological and exposure data. Overall, we illustrate a much-needed path towards standards for the optimized use of existing data, which avoids duplication of efforts, and provides a multitude of options to promote safe and sustainable nanotechnology., The work leading to this article has received funding from the European Union’s Horizon 2020 Research and Innovation programme, Grant Agreements no. 646221 (NanoReg2, 2015–2019), no. 814401 (Gov4Nano, 2019–2022) and no. 814425 (RiskGONE 2019–2023). In addition, the European Union’s 7th Framework Programme projects NANoREG (2013–2017, Grant Agreement no. 310584), NanoTEST (2008–2012, no. 201335) and ENPRA (2009–2012, no. 228789), the European Union’s Health Programme Joint Action project NANOGENOTOX (2010–2013, no. 2009 21 01) and the US NIH NCI caNanoLab portal are acknowledged for providing data

Published
2021
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