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1,010 results on '"Barrett, David M."'

2. Back Cover

Author

Barrett, David M. and Holland, Max

Published
2012

3. Cover

Author

Barrett, David M. and Holland, Max

Published
2012

4. Index

Author

Barrett, David M. and Holland, Max

Published
2012

5. Bibliography

Author

Barrett, David M. and Holland, Max

Published
2012

7. Notes

Author

Barrett, David M. and Holland, Max

Published
2012

9. Title Page

Author

Barrett, David M. and Holland, Max

Published
2012

16. Acknowledgments

Author

Barrett, David M. and Holland, Max

Published
2012

19. Blind over Cuba

Author

Barrett, David M. and Holland, Max

Subjects
BOOK REVIEWS
Published
2014

23. Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A-rearranged leukemia

Author

Chen, Changya, Yu, Wenbao, Alikarami, Fatemeh, Qiu, Qi, Chen, Chia-hui, Flournoy, Jennifer, Gao, Peng, Uzun, Yasin, Fang, Li, Davenport, James W., Hu, Yuxuan, Zhu, Qin, Wang, Kai, Libbrecht, Clara, Felmeister, Alex, Rozich, Isaiah, Ding, Yang-yang, Hunger, Stephen P., Felix, Carolyn A., Wu, Hao, Brown, Patrick A., Guest, Erin M., Barrett, David M., Bernt, Kathrin M., and Tan, Kai

Published
2022
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24. Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

Author

Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Cummins, Katherine D., Lee, Yu Gong, Pajarillo, Raymone, Chun, Inkook, Shyu, Amy, Highfill, Steven L., Price, Andrew, Zhao, Linlin, Peng, Liaomin, Granda, Brian, and Ramones, Melissa

Subjects
T cells -- Receptors -- Health aspects, Immunological research, Antigen receptors, T cell -- Health aspects -- Structure, Cellular therapy -- Research, Antigens -- Health aspects, Cellular signal transduction -- Research, Biological sciences, Health
Abstract

While CD19-directed chimeric antigen receptor (CAR) T cells can induce remission in patients with B cell acute lymphoblastic leukemia (ALL), a large subset relapse with CD19.sup.- disease. Like CD19, CD22 is broadly expressed by B-lineage cells and thus serves as an alternative immunotherapy target in ALL. Here we present the composite outcomes of two pilot clinical trials (NCT02588456 and NCT02650414) of T cells bearing a 4-1BB-based, CD22-targeting CAR in patients with relapsed or refractory ALL. The primary end point of these studies was to assess safety, and the secondary end point was antileukemic efficacy. We observed unexpectedly low response rates, prompting us to perform detailed interrogation of the responsible CAR biology. We found that shortening of the amino acid linker connecting the variable heavy and light chains of the CAR antigen-binding domain drove receptor homodimerization and antigen-independent signaling. In contrast to CD28-based CARs, autonomously signaling 4-1BB-based CARs demonstrated enhanced immune synapse formation, activation of pro-inflammatory genes and superior effector function. We validated this association between autonomous signaling and enhanced function in several CAR constructs and, on the basis of these observations, designed a new short-linker CD22 single-chain variable fragment for clinical evaluation. Our findings both suggest that tonic 4-1BB-based signaling is beneficial to CAR function and demonstrate the utility of bedside-to-bench-to-bedside translation in the design and implementation of CAR T cell therapies. A bedside-to-bench analysis identifies single-chain variable fragment linker length as an important component of chimeric antigen receptor (CAR) structure and suggests that, in contrast to CD28-based CAR T cells, tonic signaling can be beneficial for 4-1BB-based CAR T cell function., Author(s): Nathan Singh [sup.1] [sup.2] [sup.15] , Noelle V. Frey [sup.1] , Boris Engels [sup.3] , David M. Barrett [sup.4] [sup.5] , Olga Shestova [sup.2] , Pranali Ravikumar [sup.2] , [...]

Published
2021
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25. Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children

Author

Diorio, Caroline, Shaw, Pamela A., Pequignot, Edward, Orlenko, Alena, Chen, Fang, Aplenc, Richard, Barrett, David M., Bassiri, Hamid, Behrens, Edward, DiNofia, Amanda M., Gonzalez, Vanessa, Koterba, Natalka, Levine, Bruce L., Maude, Shannon L., Meyer, Nuala J., Moore, Jason H., Paessler, Michele, Porter, David L., Bush, Jenny L., Siegel, Don L., Davis, Megan M., Zhang, Donglan, June, Carl H., Grupp, Stephan A., Melenhorst, J. Joseph, Lacey, Simon F., Weiss, Scott L., and Teachey, David T.

Published
2020
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27. Partially CD3+-Depleted Unrelated and Haploidentical Donor Peripheral Stem Cell Transplantation Has Favorable Graft-versus-Host Disease and Survival Rates in Pediatric Hematologic Malignancy

Author

Seif, Alix E., Li, Yimei, Monos, Dimitri S., Heidemann, Stephanie C., Aplenc, Richard, Barrett, David M., Casper, James T., Freedman, Jason L., Grupp, Stephan A., Margolis, David A., Olson, Timothy S., Teachey, David T., Keever-Taylor, Carolyn A., Wang, Yongping, Talano, Julie-An M., and Bunin, Nancy J.

Published
2020
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28. Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2

Author

Behrens, Edward M., Diorio, Caroline, Henrickson, Sarah E., Vella, Laura A., McNerney, Kevin O., Chase, Julie, Burudpakdee, Chakkapong, Lee, Jessica H., Jasen, Cristina, Balamuth, Fran, Barrett, David M., Banwell, Brenda L., Bernt, Kathrin M., Blatz, Allison M., Chiotos, Kathleen, Fisher, Brian T., Fitzgerald, Julie C., Gerber, Jeffrey S., Gollomp, Kandace, Gray, Christopher, Grupp, Stephan A., Harris, Rebecca M., Kilbaugh, Todd J., Odom John, Audrey R., Lambert, Michele, Liebling, Emily J., Paessler, Michele E., Petrosa, Whitney, Phillips, Charles, Reilly, Anne F., Romberg, Neil D., Seif, Alix, Sesok-Pizzini, Deborah A., Sullivan, Kathleen E., Vardaro, Julie, Teachey, David T., and Bassiri, Hamid

Subjects
Immunodiagnosis -- Research, Pediatric research, Hospital patients -- Medical examination, COVID-19 -- Diagnosis, Pediatric multisystem inflammatory syndrome -- Diagnosis, Health care industry
Abstract

BACKGROUND. Initial reports from the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic described children as being less susceptible to coronavirus disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory syndrome in children (MIS-C) emerged. We report on unique hematologic and immunologic parameters that distinguish between COVID-19 and MIS-C and provide insight into pathophysiology. METHODS. We prospectively enrolled hospitalized patients with evidence of SARS-CoV-2 infection and classified them as having MIS-C or COVID-19. Patients with COVID-19 were classified as having either minimal or severe disease. Cytokine profiles, viral cycle thresholds (Cts), blood smears, and soluble C5b-9 values were analyzed with clinical data. RESULTS. Twenty patients were enrolled (9 severe COVID-19, 5 minimal COVID-19, and 6 MIS-C). Five cytokines (IFN- [gamma], IL-10, IL-6, IL-8, and TNF-[alpha]) contributed to the analysis. TNF-[alpha] and IL-10 discriminated between patients with MIS-C and severe COVID-19. The presence of burr cells on blood smears, as well as Cts, differentiated between patients with severe COVID-19 and those with MIS-C. CONCLUSION. Pediatric patients with SARS-CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C. Cytokine profiling and examination of peripheral blood smears may distinguish between patients with MIS-C and those with severe COVID-19. FUNDING. Financial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex's Lemonade Stand Foundation for Childhood Cancer; Children's Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Amato Foundations; Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; the American Academy of Allergy, Asthma, and Immunology; and the Institute for Translational Medicine and Therapeutics., Introduction Initial reports from the coronavirus disease 2019 (COVID-19) pandemic indicated that children were less severely affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than adults (1-3). The [...]

Published
2020
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31. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Author

Taylor, Deanne M., Aronow, Bruce J., Tan, Kai, Bernt, Kathrin, Salomonis, Nathan, Greene, Casey S., Frolova, Alina, Henrickson, Sarah E., Wells, Andrew, Pei, Liming, Jaiswal, Jyoti K., Whitsett, Jeffrey, Hamilton, Kathryn E., MacParland, Sonya A., Kelsen, Judith, Heuckeroth, Robert O., Potter, S. Steven, Vella, Laura A., Terry, Natalie A., Ghanem, Louis R., Kennedy, Benjamin C., Helbig, Ingo, Sullivan, Kathleen E., Castelo-Soccio, Leslie, Kreigstein, Arnold, Herse, Florian, Nawijn, Martijn C., Koppelman, Gerard H., Haendel, Melissa, Harris, Nomi L., Rokita, Jo Lynne, Zhang, Yuanchao, Regev, Aviv, Rozenblatt-Rosen, Orit, Rood, Jennifer E., Tickle, Timothy L., Vento-Tormo, Roser, Alimohamed, Saif, Lek, Monkol, Mar, Jessica C., Loomes, Kathleen M., Barrett, David M., Uapinyoying, Prech, Beggs, Alan H., Agrawal, Pankaj B., Chen, Yi-Wen, Muir, Amanda B., Garmire, Lana X., Snapper, Scott B., Nazarian, Javad, Seeholzer, Steven H., Fazelinia, Hossein, Singh, Larry N., Faryabi, Robert B., Raman, Pichai, Dawany, Noor, Xie, Hongbo Michael, Devkota, Batsal, Diskin, Sharon J., Anderson, Stewart A., Rappaport, Eric F., Peranteau, William, Wikenheiser-Brokamp, Kathryn A., Teichmann, Sarah, Wallace, Douglas, Peng, Tao, Ding, Yang-yang, Kim, Man S., Xing, Yi, Kong, Sek Won, Bönnemann, Carsten G., Mandl, Kenneth D., and White, Peter S.

Published
2019
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34. Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

Author

Ruella, Marco, Xu, Jun, Barrett, David M., Fraietta, Joseph A., Reich, Tyler J., Ambrose, David E., Klichinsky, Michael, Shestova, Olga, Patel, Prachi R., Kulikovskaya, Irina, Nazimuddin, Farzana, Bhoj, Vijay G., Orlando, Elena J., Fry, Terry J., Bitter, Hans, Maude, Shannon L., Levine, Bruce L., Nobles, Christopher L., Bushman, Frederic D., Young, Regina M., Scholler, John, Gill, Saar I., June, Carl H., Grupp, Stephan A., Lacey, Simon F., and Melenhorst, J. Joseph

Published
2018
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41. Supplementary Table S2 from Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy

Author

Chen, Gregory M., primary, Chen, Changya, primary, Das, Rajat K., primary, Gao, Peng, primary, Chen, Chia-Hui, primary, Bandyopadhyay, Shovik, primary, Ding, Yang-Yang, primary, Uzun, Yasin, primary, Yu, Wenbao, primary, Zhu, Qin, primary, Myers, Regina M., primary, Grupp, Stephan A., primary, Barrett, David M., primary, and Tan, Kai, primary

Published
2023
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42. Supplementary Figures 1 - 2 from Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

Author

Sotillo, Elena, primary, Barrett, David M., primary, Black, Kathryn L., primary, Bagashev, Asen, primary, Oldridge, Derek, primary, Wu, Glendon, primary, Sussman, Robyn, primary, Lanauze, Claudia, primary, Ruella, Marco, primary, Gazzara, Matthew R., primary, Martinez, Nicole M., primary, Harrington, Colleen T., primary, Chung, Elaine Y., primary, Perazzelli, Jessica, primary, Hofmann, Ted J., primary, Maude, Shannon L., primary, Raman, Pichai, primary, Barrera, Alejandro, primary, Gill, Saar, primary, Lacey, Simon F., primary, Melenhorst, Jan J., primary, Allman, David, primary, Jacoby, Elad, primary, Fry, Terry, primary, Mackall, Crystal, primary, Barash, Yoseph, primary, Lynch, Kristen W., primary, Maris, John M., primary, Grupp, Stephan A., primary, and Thomas-Tikhonenko, Andrei, primary

Published
2023
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43. Data from Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

Author

Teachey, David T., primary, Lacey, Simon F., primary, Shaw, Pamela A., primary, Melenhorst, J. Joseph, primary, Maude, Shannon L., primary, Frey, Noelle, primary, Pequignot, Edward, primary, Gonzalez, Vanessa E., primary, Chen, Fang, primary, Finklestein, Jeffrey, primary, Barrett, David M., primary, Weiss, Scott L., primary, Fitzgerald, Julie C., primary, Berg, Robert A., primary, Aplenc, Richard, primary, Callahan, Colleen, primary, Rheingold, Susan R., primary, Zheng, Zhaohui, primary, Rose-John, Stefan, primary, White, Jason C., primary, Nazimuddin, Farzana, primary, Wertheim, Gerald, primary, Levine, Bruce L., primary, June, Carl H., primary, Porter, David L., primary, and Grupp, Stephan A., primary

Published
2023
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44. Supplemental Data from Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells

Author

Ghassemi, Saba, primary, Nunez-Cruz, Selene, primary, O'Connor, Roddy S., primary, Fraietta, Joseph A., primary, Patel, Prachi R., primary, Scholler, John, primary, Barrett, David M., primary, Lundh, Stefan M., primary, Davis, Megan M., primary, Bedoya, Felipe, primary, Zhang, Changfeng, primary, Leferovich, John, primary, Lacey, Simon F., primary, Levine, Bruce L., primary, Grupp, Stephan A., primary, June, Carl H., primary, Melenhorst, J. Joseph, primary, and Milone, Michael C., primary

Published
2023
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45. Supplementary Methods, Tables 1 - 19, Figures 1 - 5 from Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

Author

Teachey, David T., primary, Lacey, Simon F., primary, Shaw, Pamela A., primary, Melenhorst, J. Joseph, primary, Maude, Shannon L., primary, Frey, Noelle, primary, Pequignot, Edward, primary, Gonzalez, Vanessa E., primary, Chen, Fang, primary, Finklestein, Jeffrey, primary, Barrett, David M., primary, Weiss, Scott L., primary, Fitzgerald, Julie C., primary, Berg, Robert A., primary, Aplenc, Richard, primary, Callahan, Colleen, primary, Rheingold, Susan R., primary, Zheng, Zhaohui, primary, Rose-John, Stefan, primary, White, Jason C., primary, Nazimuddin, Farzana, primary, Wertheim, Gerald, primary, Levine, Bruce L., primary, June, Carl H., primary, Porter, David L., primary, and Grupp, Stephan A., primary

Published
2023
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47. Data from Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

Author

Sotillo, Elena, primary, Barrett, David M., primary, Black, Kathryn L., primary, Bagashev, Asen, primary, Oldridge, Derek, primary, Wu, Glendon, primary, Sussman, Robyn, primary, Lanauze, Claudia, primary, Ruella, Marco, primary, Gazzara, Matthew R., primary, Martinez, Nicole M., primary, Harrington, Colleen T., primary, Chung, Elaine Y., primary, Perazzelli, Jessica, primary, Hofmann, Ted J., primary, Maude, Shannon L., primary, Raman, Pichai, primary, Barrera, Alejandro, primary, Gill, Saar, primary, Lacey, Simon F., primary, Melenhorst, Jan J., primary, Allman, David, primary, Jacoby, Elad, primary, Fry, Terry, primary, Mackall, Crystal, primary, Barash, Yoseph, primary, Lynch, Kristen W., primary, Maris, John M., primary, Grupp, Stephan A., primary, and Thomas-Tikhonenko, Andrei, primary

Published
2023
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