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1,062 results on '"Barreto, George E"'

2. A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions

Author

Borda, Miguel German, Barreto, George E., Baldera, Jonathan Patricio, de Lucia, Chiara, Khalifa, Khadija, Bergland, Anne Katrine, Pola, Ilaria, Botero-Rodríguez, Felipe, Siow, Richard C., Kivipelto, Miia, Zetterberg, Henrik, Ashton, Nicholas J., Ballard, Clive, and Aarsland, Dag

Published
2024
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10. Curcumin Can Bind and Interact with CRP: An in silico Study

Author

Shakour, Neda, Cabezas, Ricardo, Santos, Janneth González, Barreto, George E., Jamialahmadi, Tannaz, Hadizadeh, Farzin, Sahebkar, Amirhossein, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Xiao, Junjie, Series Editor, Steinlein, Ortrud, Series Editor, Barreto, George E., editor, and Sahebkar, Amirhossein, editor

Published
2021
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11. In Silico Identification of Novel Interactions for FABP5 (Fatty Acid-Binding Protein 5) with Nutraceuticals: Possible Repurposing Approach

Author

Cabezas, Ricardo, Sahebkar, Amirhossein, Echeverria, Valentina, Santos, Janneth González, Ashraf, Ghulam Md, Barreto, George E., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Xiao, Junjie, Series Editor, Steinlein, Ortrud, Series Editor, Barreto, George E., editor, and Sahebkar, Amirhossein, editor

Published
2021
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12. Protective Effects of Intravenous Magnesium Sulfate in Stroke Patients Receiving Amiodarone: A Randomized Controlled Trial

Author

Panahi, Yunes, Mojtahedzadeh, Mojtaba, Najafi, Atabak, Gheini, Mohammadreza, Abdollahi, Mohammad, Sharifzadeh, Mohammad, Ahmadi, Arezoo, Ganjali, Shiva, Rajaee, Seyyed Mahdi, Barreto, George E., Sahebkar, Amirhossein, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Xiao, Junjie, Series Editor, Steinlein, Ortrud, Series Editor, Barreto, George E., editor, and Sahebkar, Amirhossein, editor

Published
2021
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21. Nutrient Intake and Its Association with Appendicular Total Lean Mass and Muscle Function and Strength in Older Adults : A Population-Based Study

Author

Borda, Miguel German, Samuelsson, Jessica, Cederholm, Tommy, Baldera, Jonathan Patricio, Perez-Zepeda, Mario Ulises, Barreto, George E., Zettergren, Anna, Kern, Silke, Ryden, Lina, Gonzalez-Lara, Mariana, Salazar-Londono, Salomon, Duque, Gustavo, Skoog, Ingmar, Aarsland, Dag, Borda, Miguel German, Samuelsson, Jessica, Cederholm, Tommy, Baldera, Jonathan Patricio, Perez-Zepeda, Mario Ulises, Barreto, George E., Zettergren, Anna, Kern, Silke, Ryden, Lina, Gonzalez-Lara, Mariana, Salazar-Londono, Salomon, Duque, Gustavo, Skoog, Ingmar, and Aarsland, Dag

Abstract

Treatment options for sarcopenia are currently limited, and primarily rely on two main therapeutic approaches: resistance-based physical activity and dietary interventions. However, details about specific nutrients in the diet or supplementation are unclear. We aim to investigate the relationship between nutrient intake and lean mass, function, and strength. Data were derived from the Gothenburg H70 birth cohort study in Sweden, including 719,70-year-olds born in 1944 (54.1% females). For independent variables, the diet history method (face-to-face interviews) was used to estimate habitual food intake during the preceding three months. Dependent variables were gait speed (muscle performance), hand grip strength (muscle strength), and the appendicular lean soft tissue index (ALSTI). Linear regression analyses were performed to analyze the relationship between the dependent variables and each of the covariates. Several nutrients were positively associated with ALSTI, such as polyunsaturated fatty acids (DHA, EPA), selenium, zinc, riboflavin, niacin equivalent, vitamin B12, vitamin D, iron, and protein. After correction for multiple comparisons, there were no remaining correlations with handgrip and gait speed. Findings of positive correlations for some nutrients with lean mass suggest a role for these nutrients in maintaining muscle volume. These results can be used to inform clinical trials to expand the preventive strategies and treatment options for individuals at risk of muscle loss and sarcopenia.

Published
2024
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22. Gonadal hormone deprivation regulates response to tibolone in neurodegenerative pathways

Author

Science Foundation Ireland, Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, #NODATA#, McGovern, Andrew J., Arévalo, María Ángeles, Ciordia, Sergio, Garcia-Segura, Luis Miguel, Barreto, George E., Science Foundation Ireland, Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, #NODATA#, McGovern, Andrew J., Arévalo, María Ángeles, Ciordia, Sergio, Garcia-Segura, Luis Miguel, and Barreto, George E.

Abstract

Gonadal hormone deprivation (GHD) and decline such as menopause and bilateral oophorectomy are associated with an increased risk of neurodegeneration. Yet, hormone therapies (HTs) show varying efficacy, influenced by factors such as sex, drug type, and timing of treatment relative to hormone decline. We hypothesize that the molecular environment of the brain undergoes a transition following GHD, impacting the effectiveness of HTs. Using a GHD model in mice treated with Tibolone, we conducted proteomic analysis and identified a reprogrammed response to Tibolone, a compound that stimulates estrogenic, progestogenic, and androgenic pathways. Through a comprehensive network pharmacological workflow, we identified a reprogrammed response to Tibolone, particularly within "Pathways of Neurodegeneration", as well as interconnected pathways including "cellular respiration", "carbon metabolism", and "cellular homeostasis". Analysis revealed 23 proteins whose Tibolone response depended on GHD and/or sex, implicating critical processes like oxidative phosphorylation and calcium signalling. Our findings suggest the therapeutic efficacy of HTs may depend on these variables, suggesting a need for greater precision medicine considerations whilst highlighting the need to uncover underlying mechanisms.

Published
2024

27. Nutrient Intake and its Association with Appendicular Total Lean Mass, Function and Strength in Older Adults: A Population-Based Study

Author

Borda, Miguel Germán, primary, Samuelsson, Jessica, additional, Cederholm, Tommy, additional, Baldera, Jonathan Patricio, additional, Perez-Zepeda, Mario Ulises, additional, Barreto, George E., additional, Zettergren, Anna, additional, Kern, Silke, additional, Lina, Rydén, additional, Gonzalez-Lara, Mariana, additional, Salazar-Londoño, Salomón, additional, Duque, Gustavo, additional, Skoog, Ingmar, additional, and Aarsland, Dag, additional

Published
2024
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39. Protective Effects of Intravenous Magnesium Sulfate in Stroke Patients Receiving Amiodarone: A Randomized Controlled Trial

Author

Panahi, Yunes, primary, Mojtahedzadeh, Mojtaba, additional, Najafi, Atabak, additional, Gheini, Mohammadreza, additional, Abdollahi, Mohammad, additional, Sharifzadeh, Mohammad, additional, Ahmadi, Arezoo, additional, Ganjali, Shiva, additional, Rajaee, Seyyed Mahdi, additional, Barreto, George E., additional, and Sahebkar, Amirhossein, additional

Published
2021
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42. Enzymatic Metabolic Switches of Astrocyte Response to Lipotoxicity as Potential Therapeutic Targets for Nervous System Diseases.

Author

Angarita-Rodríguez, Andrea, Matiz-González, J. Manuel, Pinzón, Andrés, Aristizabal, Andrés Felipe, Ramírez, David, Barreto, George E., and González, Janneth

Subjects
NEUROLOGICAL disorders, DRUG target, PHOSPHOGLYCERATE kinase, PALMITIC acid, METABOLIC models, DEHYDROGENASES
Abstract

Astrocytes play a pivotal role in maintaining brain homeostasis. Recent research has highlighted the significance of palmitic acid (PA) in triggering pro-inflammatory pathways contributing to neurotoxicity. Furthermore, Genomic-scale metabolic models and control theory have revealed that metabolic switches (MSs) are metabolic pathway regulators by potentially exacerbating neurotoxicity, thereby offering promising therapeutic targets. Herein, we characterized these enzymatic MSs in silico as potential therapeutic targets, employing protein–protein and drug–protein interaction networks alongside structural characterization techniques. Our findings indicate that five MSs (P00558, P04406, Q08426, P09110, and O76062) were functionally linked to nervous system drug targets and may be indirectly regulated by specific neurological drugs, some of which exhibit polypharmacological potential (e.g., Trifluperidol, Trifluoperazine, Disulfiram, and Haloperidol). Furthermore, four MSs (P00558, P04406, Q08426, and P09110) feature ligand-binding or allosteric cavities with druggable potential. Our results advocate for a focused exploration of P00558 (phosphoglycerate kinase 1), P04406 (glyceraldehyde-3-phosphate dehydrogenase), Q08426 (peroxisomal bifunctional enzyme, enoyl-CoA hydratase, and 3-hydroxyacyl CoA dehydrogenase), P09110 (peroxisomal 3-ketoacyl-CoA thiolase), and O76062 (Delta(14)-sterol reductase) as promising targets for the development or repurposing of pharmacological compounds, which could have the potential to modulate lipotoxic-altered metabolic pathways, offering new avenues for the treatment of related human diseases such as neurological diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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