219 results on '"Barrena S"'
Search Results
2. SARCOPENIA AS A PROGNOSTIC FACTOR IN PATIENTS WITH HEPATOBLASTOMA: DOES IT INFLUENCE SURGICAL OUTCOMES AND SURVIVAL?
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Muñoz-Serrano AJ, Estefanía-Fernández K, Oterino C, Ramírez Amoros C, Navarro G, Ana Sastre Urgelles, Antonio Pérez-Martínez, Barrena S, Hernández Oliveros F, and Leopoldo Martínez-Martínez
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Aim: Sarcopenia is associated with poor prognosis in adult oncologic patients, with little evidence of this association in pediatric population, including hepatoblastoma. Methods: Retrospective study in patients with hepatoblastoma, divided into those with or without sarcopenia. Sarcopenia was assessed by measuring psoas muscle area (PMA) at L4-L5 level on the CT/MR and defined as z-score values ≤2. Relapse and mortality were analyzed. Results: Twenty-one patients (57.1% male) were included, with median age 35.7 months (IQR: 23.5-58.5). Seven (33.3%) had sarcopenia on initial studies compared to 14 (66.7%) who did not. No differences were found between groups in age, weight, PRETEX, surgical treatment or a-fetoprotein levels. Twelve (57.1%) underwent liver resection and 9 (42.9%) liver transplantation. Sarcopenia was associated with a higher rate of metastases at diagnosis (49.2% vs 0.0%; p=0.026) and surgical complications (57.1% vs 21.4%, p=0.047). After a median follow-up of 65.1 months (1.7-144.8), 2 patients (28.6%) had tumor relapse in sarcopenic group compared to 1 (7.1%) in non-sarcopenic group. Two patients died in sarcopenic group and 1 in non-sarcopenic group. Median event-free survival (EFS) was lower in sarcopenic group (100.38±25.63vs118.91±11.52 months) as well as overall survival (OS) (101.72±24.86 vs 121.78±8.75 months) with no statistical significance. Five-year EFS was also lower in sarcopenic group (71%vs93%) as well as 5-year OS (71%vs87%). Conclusions: Sarcopenia at diagnosis was associated with a higher rate of metastases and surgical complications in hepatoblastoma. Our data shows the first evidence of its role as a possible poor prognostic factor, influencing survival and risk of relapse.
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- 2023
3. CD34(+)CD19(-)CD22(+) B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies
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Bueno, C, Barrena, S, Bataller, A, Ortiz-Maldonado, V, Elliott, N, O'Byrne, S, Wang, G, Rovira, M, Gutierrez-Agüera, F, Trincado, JL, Gonzalez, M, Morgades, M, Sorigué, M, Barcena, P, Zanetti, SR, Torrebadell, M, Vega-García, N, Rives, S, Mallo, M, Sole, F, Mead, AJ, Roberts, I, Thongjuea, S, Psaila, B, Juan, M, Delgado, J, Urbano-Ispizua, Á, Ribera, J-M, Orfao, A, Roy, A, Menéndez, P, European Research Council, European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Cancer Research UK, Wellcome Trust, Generalitat de Catalunya, and University of Oxford
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B-Lymphocytes ,Lymphoid Neoplasia ,Immunobiology and Immunotherapy ,Sialic Acid Binding Ig-like Lectin 2 ,Immunology ,Antigens, CD19 ,chemical and pharmacologic phenomena ,hemic and immune systems ,Antigens, CD34 ,Cell Biology ,Hematology ,Biochemistry ,Burkitt Lymphoma ,Immunophenotyping ,immune system diseases ,Recurrence ,hemic and lymphatic diseases ,Humans ,Blood Commentary ,Brief Reports ,Free Research Articles ,In Situ Hybridization, Fluorescence - Abstract
CD19-directed immunotherapies have revolutionized the treatment of advanced B-cell acute lymphoblastic leukemia (B-ALL). Despite initial impressive rates of complete remission (CR) many patients ultimately relapse. Patients with B-ALL successfully treated with CD19-directed T cells eventually relapse, which, coupled with the early onset of CD22 expression during B-cell development, suggests that preexisting CD34+CD22+CD19− (pre)-leukemic cells represent an “early progenitor origin-related” mechanism underlying phenotypic escape to CD19-directed immunotherapies. We demonstrate that CD22 expression precedes CD19 expression during B-cell development. CD34+CD19−CD22+ cells are found in diagnostic and relapsed bone marrow samples of ∼70% of patients with B-ALL, and their frequency increases twofold in patients with B-ALL in CR after CD19 CAR T-cell therapy. The median of CD34+CD19−CD22+ cells before treatment was threefold higher in patients in whom B-ALL relapsed after CD19-directed immunotherapy (median follow-up, 24 months). Fluorescence in situ hybridization analysis in flow-sorted cell populations and xenograft modeling revealed that CD34+CD19−CD22+ cells harbor the genetic abnormalities present at diagnosis and initiate leukemogenesis in vivo. Our data suggest that preleukemic CD34+CD19−CD22+ progenitors underlie phenotypic escape after CD19-directed immunotherapies and reinforce ongoing clinical studies aimed at CD19/CD22 dual targeting as a strategy for reducing CD19− relapses. The implementation of CD34/CD19/CD22 immunophenotyping in clinical laboratories for initial diagnosis and subsequent monitoring of patients with B-ALL during CD19-targeted therapy is encouraged., The work in P.M. and C.B.’s Laboratory was supported by the European Research Council (CoG-2014-646903, PoC-2018-811220) and the Spanish Ministry of Economy and Competitiveness (SAF2016-80481R, PID2019-108160RB-I00) (P.M.); the ISCIII (ISCIII/FEDER, PI17/01028 and PI20/00822), the Spanish Association against Cancer (AECC), and the FERO Foundation (C.B.). P.M. and J.M.R. acknowledge the support of ISCIII-RICORS within the Next Generation EU program (Plan de Recuperación, Transformación y Resiliencia). N.E. is supported by Cancer Research UK and a Children and Young People’s Cancer Innovation Award (DRCPGM\100058). A.R. is supported by a Wellcome Trust Clinical Research Career Development Fellowship (216632/Z/19/Z). A.O. was supported by ISCIII (PI19/011183). F.S. was supported by AGAUR/Generalitat de Catalunya (SGR288). The single-cell transcriptomic analysis was supported by MRC Discovery award MRCDA 0816-11 and the MRC WIMM Single Cell Facility and MRC-funded Oxford Consortium for Single-Cell Biology (MR/M00919X/1) provided assistance.
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- 2022
4. Beyond the screen
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Margagliotta, A, De Marco, P, Álvarez Barrena, S, Enrico Prandi and Paolo Strina, Margagliotta, A, De Marco, P, and Álvarez Barrena, S
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Architecture, project, technology, corporeality ,Settore ICAR/14 - Composizione Architettonica E Urbana - Abstract
The didactic experiences in the field of architectural design, in courses that have always had a strong workshop character, have been varied in recent years and have been carried out in different variants that, when considered as a whole, allow us to reflect on the problems and the challenges faced during the pandemic. Indeed, a didactic normally conducted with compulsory attendance suffered in a sudden andunexpected way from the cancellation of physical presence, the loss of contact with people and the “corporeality” of the project. Moreover, the absence of the physical space of the classroom (a scene inherent to the laboratory) soon led to the search for new tools and appropriate methods that must adapt to constantly changing situations, depending on the progress of the pandemic, transposing everything behind a screen. These experiences confirm that despite the technical-technological progress that also affects the world of design teaching, it is necessary to keep the cornerstones of architecture clear, as the method cannot ignore thinking and the concreteness of doing, since architecture is always experiential and not media.
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- 2021
5. Reliability of the Hirschsprung-Associated Enterocolitis Score in Clinical Practice
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Javier Jimenez Gomez, Manuel Lopez Santamaria, Barrena S, Paloma Triana Junco, Ane M. Andres Moreno, Alejandra Vilanova Sanchez, Mariela Dore, María de Ceano-Vivas, and Leopoldo Martinez
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Diarrhea ,Male ,Hirschsprung associated enterocolitis ,medicine.medical_specialty ,Risk Assessment ,Severity of Illness Index ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Internal medicine ,Severity of illness ,medicine ,Humans ,In patient ,Hirschsprung Disease ,Retrospective Studies ,Enterocolitis ,business.industry ,Infant, Newborn ,Infant ,Reproducibility of Results ,Retrospective cohort study ,Length of Stay ,Anti-Bacterial Agents ,Clinical Practice ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,cardiovascular system ,Abdomen ,Female ,Surgery ,medicine.symptom ,business ,Abnormal laboratory findings - Abstract
Introduction There is a lack of an agreed Hirschsprung-associated enterocolitis (HAEC) definition. In 2009, a HAEC score was proposed for the diagnosis of HAEC episodes. Our aim was to apply the HAEC score on HAEC episodes to determine its diagnostic efficiency and whether it correlated to its severity. Methods Retrospective study of patients with HAEC admitted between 2000 and 2016. Episodes of HAEC were identified and the HAEC score was calculated. A cut-off of ≥ 10 according to Pastor et al and ≥ 4 according to Frykman et al were used. A Pearson's correlation coefficient was performed for outcome variable: length-of-stay (LOS). Results Note that 21/93 (22.6%) patients with Hirschsprung's disease presented 50 HAEC episodes with a median of 2 (1–5) episodes during an 8.3-year (2–15.6) follow-up. The most common symptoms were foul-smelling (86% [43/50]) and explosive (60% [30/50]) diarrhea. Physical findings showed a distended abdomen (76% [38/50]) and fever (60% [30/50]) with dilated bowel (82% [41/50]) and rectosigmoid cut-off (80% [40/50]) identified on X-rays. Only 34% (17/50) showed abnormal laboratory findings. Patients were admitted with a median LOS of 7 days (1–28). A HAEC score of 9 (2–16) was found, and only 50% (25/50) of patients met the initial criteria (score of 10 points). However, the use of a 4-point cut-off would have allowed the diagnosis of 98% (49/50) of the patients. A positive linear correlation was found for LOS and HAEC score (r = 0.3, p = 0.014). Conclusion There is no standardized definition for HAEC. The initial HAEC score cut-off is restrictive and might fail to identify milder episodes. The positive correlation with LOS and thus HAEC severity might aid in patient information and anticipation of treatment.
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- 2019
6. Best Oxygenation Index on Day 1: A Reliable Marker for Outcome and Survival in Infants with Congenital Diaphragmatic Hernia
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Ruttenstock, Elke, Wright, Naomi, Barrena, S., Krickhahn, Annika, Castellani, Christoph, Desai, Ashish P., Rintala, Risto, Tovar, Juan, Till, Holger, Zani, Augusto, Saxena, Amulya, and Davenport, Mark
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- 2015
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7. t(1;19)(q23;p13) TCF3-PBX1 May Not Be an Intermediate-Risk Subtype in Adult B-Cell Precursor Acute Lymphoblastic Leukemia Patients Treated With MRD-Oriented Protocols from the PETHEMA Group
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Ribera, J, Morgades, M, Granada, I, Torrent, A, Zamora, L, Gonzalez, T, Ciudad, J, Barrena, S, Such, E, Avetisyan, G, Calasanz, MJ, Genesca, E, Gonzalez-Gil, C, Fuster-Tormo, F, Mercadal, S, Maluquer, C, Coll, R, Gonzalez-Campos, J, Tormo, M, Garcia-Cadenas, I, Nomdedeu, J, Gil, C, Cervera, M, Escoda, L, Montesinos, P, Barba, P, Esteve, J, Diaz-Beya, M, Martinez-Sanchez, P, Martinez-Lopez, J, Novo, A, Queipo, MP, Bermudez, A, Bergua, J, Olave, MT, de Rueda, B, Artola, MT, Hernandez-Rivas, JM, Orfao, A, and Ribera, JM
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TCF3-PBX1 ,PETHEMA ,outcome ,MRD-oriented trials ,acute lymphoblastic leukemia - Published
- 2021
8. The Cluster HEritage project with XMM-Newton : Mass Assembly and Thermodynamics at the Endpoint of structure formation
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M. Arnaud, S. Ettori, G. W. Pratt, M. Rossetti, D. Eckert, F. Gastaldello, R. Gavazzi, S.T. Kay, L. Lovisari, B.J. Maughan, E. Pointecouteau, M. Sereno, I. Bartalucci, A. Bonafede, H. Bourdin, R. Cassano, R.T. Duffy, A. Iqbal, S. Maurogordato, E. Rasia, J. Sayers, F. Andrade-Santos, H. Aussel, D.J. Barnes, R. Barrena, S. Borgani, S. Burkutean, N. Clerc, P.-S. Corasaniti, J.-C. Cuillandre, S. De Gr
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- 2021
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9. Routine Ultrasound Control after Successful Intussusception Reduction in Children: Is It Really Necessary?
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Antonio Jesús Muñoz-Serrano, Leopoldo Martinez, Miriam Miguel-Ferrero, Manuel Lopez Santamaria, Barrena S, Bonifacio Delgado, Antonella García, and Carlos Delgado-Miguel
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medicine.medical_specialty ,medicine.medical_treatment ,Asymptomatic ,Group B ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,030225 pediatrics ,Intussusception (medical disorder) ,Edema ,medicine ,Humans ,Mass Screening ,Retrospective Studies ,Ultrasonography ,business.industry ,Ileal Diseases ,Ultrasound ,Infant ,Retrospective cohort study ,Enema ,Length of Stay ,medicine.disease ,Surgery ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Vomiting ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Intussusception ,Needs Assessment - Abstract
Introduction Recurrence of ileocolic intussusception (ICI) has been related to residual bowel wall edema after enema reduction. Early oral tolerance has been associated with a higher risk of re-intussusception, so an imaging test (ultrasound) has traditionally been performed before restarting oral tolerance. Our aim is to analyze the cost-effectiveness of performing a routine ultrasound in patients who remain asymptomatic after successful enema reduction. Materials and Methods A retrospective observational study was performed in patients with ICI who underwent a successful enema reduction between 2005 and 2019 and distributed in two groups according to whether or not a routine ultrasound was performed before restarting oral tolerance: group A (ultrasound) or B (no ultrasound). We analyzed demographic, clinical and laboratory variables, length of hospital stay, and recurrence rate. Results We included 366 patients who presented 373 ICI episodes (165 in group A and 208 in group B), without significant differences in gender and age. Group A patients presented a higher percentage of vomiting and bloody stools than those in group B without differences in the other clinical features studied, time of evolution, or laboratory variables. Group A presented a higher length of hospital stay than group B (36 vs. 24 hours), although it was not statistically significant (p = 0.30). No statistically significant differences were observed in the recurrence rate between both groups (10.3% A vs. 10.8% B; p = 0.83). Conclusion Performing routine ultrasound before restarting oral tolerance in asymptomatic patients after successful ICI reduction does not decrease the risk of re-intussusception and should not be routinely encouraged.
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- 2020
10. Surgical treatment of chronic inflammatory bowel disease in children
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Barrena, S., Martínez, L., Hernandez, F., Lassaletta, L., Lopez-Santamaria, M., Prieto, G., Larrauri, J., and Tovar, J. A.
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- 2011
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11. The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal/reactive and myelodysplastic syndrome precursors
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Matarraz, S, López, A, Barrena, S, Fernandez, C, Jensen, E, Flores, J, Bárcena, P, Rasillo, A, Sayagues, J M, Sánchez, M L, Hernandez-Campo, P, Hernandez Rivas, J M, Salvador, C, Fernandez-Mosteirín, N, Giralt, M, Perdiguer, L, and Orfao, A
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- 2008
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12. Unraveling IKZF1 Deletion Therapeutic Vulnerabilities in Adult B-Cell Precursor Acute Lymphoblastic Leukemia
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Ribera, J, Morgades, M, Malinverni, R, Zamora, L, Vives, S, Batlle, M, Torrent, A, Chapchap, E, Garcia, O, Mallo, M, Granada, I, Ruiz-Xiville, N, De Haro, N, Gonzalez-Gil, C, Genesca, E, Coll, R, Mercadal, S, Escoda, L, Montesinos, P, Gomez-Segui, I, Pratcorona, M, Nomdedeu, J, Tormo, M, Martinez-Lopez, J, Barba, P, Esteve, J, Gonzalez-Campos, J, Ciudad, J, Barrena, S, Buschbeck, M, Francesc Solé, Feliu, E, Orfao, A, Hernandez-Rivas, JM, and Ribera, JM
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therapeutics ,acute lymphoblastic leukemia ,Ikaros ,ALL ,RNASeq - Published
- 2020
13. The contribution of Wenceslao Castanares to the studies of C. S. Peirce
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Barrena, S. F. (Sara F.) and Nubiola, J. (Jaime)
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Wenceslao Castañares ,History of Semiotic Thought ,Pierce ,Studies on Peirce ,Historia del Pensamiento Semiótico ,Percian work ,C.S ,Semiótica ,Obra perciana ,Semiotics ,Estudios sobre Peirce - Abstract
Este texto describe la producción científica del profesor Wenceslao Castañares incidiendo en su contribución al conocimiento de la obra de Charles Sanders Peirce. Wenceslao Castañares –por delante y por encima de cualquier otro– fue la persona clave para el descubrimiento del pensamiento de Peirce en el mundo hispánico. No solo logró que se le llegara a conocer, sino que contribuyó decisivamente a la comprensión de la obra peirceana y al desarrollo de las cuestiones que el pensamiento de Peirce planteaba en muy diversas áreas. Los autores revisan el perfil humano, las aportaciones esenciales y valoran en detalle la importancia del legado de este profesor. This text describes the scientific production of Professor Wenceslao Castañares, noting specifically his contribution to the knowledge of the works of Charles Sanders Peirce. Wenceslao Castañares –ahead and above anyone else– was the key person in discovering Peirce’s thought in the Hispanic world. Not only did he get to know him, but he contributed decisively to the understanding of the Peircean works and to the development of the questions that Peirce’s thought posed in many different areas. The authors review the human profile, the essential contributions and assess in detail the importance of this professor’s legacy.
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- 2020
14. Neutropthil-to-Lymphocyte Ratio as a Predictor of Postsurgical Intraabdominal Abscess in Children Operated for Acute Appendicitis
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Antonio Jesús Muñoz-Serrano, Leopoldo Martínez, Barrena S, Carlos Delgado-Miguel, Miriam Miguel-Ferrero, M Velayos, Vanesa Núñez, K Estefanía, UAM. Departamento de Anatomía, Histología y Neurociencia, and UAM. Departamento de Pediatría
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medicine.medical_specialty ,Medicina ,Lymphocyte ,acute appendicitis ,Peritonitis ,Fibrinogen ,Gastroenterology ,Pediatrics ,children ,Internal medicine ,Neutrophil-to-lymphocyte ratio (NLR) ,medicine ,Appendectomy ,Abdominal abscess ,Abscess ,Children ,neutrophil-to-lymphocyte ratio (NLR) ,Original Research ,Acute appendicitis ,Receiver operating characteristic ,business.industry ,Area under the curve ,lcsh:RJ1-570 ,Retrospective cohort study ,lcsh:Pediatrics ,medicine.disease ,appendectomy ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,business ,abdominal abscess ,medicine.drug - Abstract
Aimof the study: Postoperative intra-abdominal abscess (PIAA) is a frequent and severe complication of acute appendicitis (AA) with peritonitis. The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker that has been related to the development of peritonitis; however, its diagnostic role in predicting PIAA has not been evaluated. This is the first study that analyzes the usefulness of NLR as a predictor of PIAA in children operated for AA. Material and Methods: Retrospective observational study in children operated for AA in our institution during 2017–2018. Patients aged under 5 years or with incomplete laboratory determinations at hospital admission (blood count, C-reactive protein, and fibrinogen) were excluded. Demographic and laboratory parameters and the development of PIAA were analyzed. NLR was calculated by dividing the absolute number of neutrophils by the absolute number of lymphocytes. Bymeans of ROC curves, we determined the sensitivity and specificity of the different laboratory parameters to predict the development of PIAA. Results: A total of 388 patients aged 10.5 ± 2.9 year were included. Twenty (5.2%) developed PIAA. NLR presented an area under the curve (AUC) of 0.85, significantly higher than the determination of leukocytes (AUC 0.69, p < 0.001), neutrophils (AUC 0.74, p < 0.001), fibrinogen (AUC 0.68, p < 0.001) and C-reactive protein (AUC 0.73, p < 0.001). We estimated the optimal cut-off point of NLR > 10.5, with a sensitivity of 85% and a specificity of 75.2%. Conclusions: NLR is the laboratory parameter with the highest sensitivity and specificity for predicting the development of PIAA in children operated for AA. It can be useful as a predictor of worse postoperative course.
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- 2019
15. Using Tissue Expanders as a Choice for the Treatment of Congenital Facial Nevus in the Young Child
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Miriam Miguel, Alba Sánchez Galán, Mariela Dore, Martha Isabel Romo Muñoz, Bryant Noriega Rebolledo, Juan Carlos López-Gutiérrez, Vanesa Nuñez Cerezo, Mercedes Diaz, Barrena S, and Paloma Triana Junco
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Male ,medicine.medical_specialty ,Skin Neoplasms ,Tissue Expansion ,030230 surgery ,Dehiscence ,03 medical and health sciences ,0302 clinical medicine ,Antibiotic therapy ,medicine ,Humans ,Nevus ,Tissue expander ,Nevus, Pigmented ,Young child ,business.industry ,Infant ,Tissue Expansion Devices ,medicine.disease ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Child, Preschool ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Female ,Surgical excision ,Eyelid ,Implant ,Facial Neoplasms ,business ,Follow-Up Studies - Abstract
Objective One of the principal objectives in treatment of facial nevus is to minimize psychological damage and encourage the child's schooling by the best possible cosmetic result. There are several therapeutic techniques: grafts, flaps, dermal regenerator, and tissue expanders. Materials and Methods We reviewed 10 patients with facial nevus higher than 10 cm treated in the past 8 years. Our treatment protocol includes serial expander implant to remove everything that does not involve the eyelid and nasal pyramid. Ten patients were included, between 8 and 36 months of age. A median of 4 (2–6) surgeries were conducted, and the number of implanted expanders was 1 to 3 in each session. There were only minor complications in two patients, infection that responded to antibiotic therapy and minimal dehiscence of incision forcing resuturing. The median follow-up was 1.6 (1.3–3.4) years. Conclusion Tissue expansion has become in recent years the treatment of choice for facial nevus in children, obtaining the best aesthetic result because the defect is covered with similar characteristics in color, texture, and relief skin. It is essential that the reconstruction is done by specialized units and we recommend complete surgical excision before starting school.
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- 2018
16. Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation
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Barrena, S, Almeida, J, Yunta, M, López, A, Fernández-Mosteirín, N, Giralt, M, Romero, M, Perdiguer, L, Delgado, M, Orfao, A, and Lazo, P A
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- 2005
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17. Quantitative analysis of bcl-2 expression in normal and leukemic human B-cell differentiation
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Menendez, P, Vargas, A, Bueno, C, Barrena, S, Almeida, J, de Santiago, M, López, A, Roa, S, San Miguel, J F, and Orfao, A
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- 2004
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18. Automated pattern-guided principal component analysis vs expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: a step forward in the standardization of clinical immunophenotyping
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Costa, E S, Pedreira, C E, Barrena, S, Lecrevisse, Q, Flores, J, Quijano, S, Almeida, J, del Carmen García-Macias, M, Bottcher, S, Van Dongen, J JM, and Orfao, A
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- 2010
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19. Is Intraoperative Fluoroscopy Necessary for Central Venous Port System Placement in Children?
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Barrena S, Paloma Triana Junco, Mariela Dore, Javier Jimenez Gomez, Alba Sánchez Galán, and Leopoldo Martinez
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Male ,Catheterization, Central Venous ,Intraclass correlation ,Radiation Dosage ,03 medical and health sciences ,Electrocardiography ,Intraoperative Period ,0302 clinical medicine ,Port (medical) ,030225 pediatrics ,Monitoring, Intraoperative ,medicine ,Fluoroscopy ,Humans ,Prospective Studies ,Prospective cohort study ,Child ,Ultrasonography, Interventional ,medicine.diagnostic_test ,business.industry ,Radiation Exposure ,Confidence interval ,Catheter ,030220 oncology & carcinogenesis ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Surgery ,Female ,Anatomic Landmarks ,Jugular Veins ,Nuclear medicine ,business - Abstract
Introduction Central venous port (CVP) placement is traditionally performed under fluoroscopy guidance. However, efforts for radiation dose reduction in children have allowed the introduction of ultrasound guidance (USG) and anatomic landmarks as an alternative technique for CVP placement. The aim of this study is to determine whether intraoperative fluoroscopy (IF) is required to confirm the correct position of the catheter tip in children. Patients and Methods A prospective, single-center study was performed between July and December 2017. Standard venous access site was the right internal jugular vein under USG. Estimated catheter length (ECL) was measured using anatomic landmarks. Ideal catheter length (ICL) was measured after placement under fluoroscopy guidance in the same patient. Age, sex, radiation dose, and complications were also analyzed. A t-test for paired samples and intraclass correlation coefficient were performed to analyze results. Results A total of 30 consecutive patients aged 7 ± 2 years underwent CVP placement. The mean ECL was 17.1 ± 1.8 cm, while the mean ICL was 17.7 ± 1.8 cm. The mean difference between measurements was 0.28 cm (95% confidence interval [CI], –0.29 to 0.86; p = 0.324). Intraclass correlation coefficient analysis showed an agreement of 0.95 (95% CI, 0.91–0.98) between measurements. Mean radiation exposure during the procedure was 1.060.78 mGym2 during 0.34 ± 0.6 minutes. There were no complications registered during CVP placement. Conclusion The correlation between IF and USG and anatomically guided catheter tip placement is optimal. These results suggest that fluoroscopy and the radiation exposure it entails can be safely avoided in selected children.
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- 2018
20. Discrimination of biclonal B-cell chronic lymphoproliferative neoplasias by tetraspanin antigen expression
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Barrena, S, Almeida, J, Yunta, M, López, A, Díaz-Mediavilla, J, Orfao, A, and Lazo, P A
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- 2005
21. José VIDAL, Mariano RUIZ y Santiago PONS, ¿Nueva evangelización desde las parroquias?, Valencia: Facultad de Teología San Vicente Ferrer, 2018, 447 pp., 15,5 x 21,5, ISBN 978-84-95269-80-5. [RECENSIÓN]
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Barrena, S. F. (Sara F.)
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- 2018
22. BALLABIO, ALESSANDRO, Experiencia y creatividad en C. S. Peirce y M. Merleau-Ponty, Aula de Humanidades, Bogotá, 2016, 314 pp. [RECENSIÓN]
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Barrena, S. F. (Sara F.)
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- 2018
23. EVALUATION OF BONE MARROW INFILTRATION BY MULTIDIMENSIONAL FLOW CYTOMETRY IN PATIENTS WITH DIFFUSE LARGE B-CELL LYMPHOMA: SUB-STUDY OF A PHASE 2 GELTAMO CLINICAL TRIAL
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Baile, M., primary, Barrena, S., additional, Sancho, J., additional, Grande, C., additional, Fernández, R., additional, Batlle, A., additional, Peñarrubia, M., additional, Peñalver, F., additional, Hernández-Rivas, J., additional, Guinea, M., additional, Pérez, J., additional, García-Álvarez, M., additional, Alcoceba, M., additional, Vidriales, B., additional, Orfao, A., additional, and Martín, A., additional
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- 2019
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24. Reliability of the Hirschsprung-Associated Enterocolitis Score in Clinical Practice
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Vilanova Sanchez, Alejandra, primary, Triana Junco, Paloma, primary, Barrena, S., primary, De Ceano-Vivas, María, primary, Jimenez Gomez, Javier, primary, Andres Moreno, Ane, primary, Lopez Santamaria, Manuel, primary, Martinez, Leopoldo, primary, and Dore, Mariela, additional
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- 2019
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25. Best Oxygenation Index on Day 1: A Reliable Marker for Outcome and Survival in Infants with Congenital Diaphragmatic Hernia
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Barrena S, Augusto Zani, Naomi Wright, Risto Rintala, Ashish Desai, Mark Davenport, Holger Till, Juan A. Tovar, Annika Krickhahn, Amulya K. Saxena, Christoph Castellani, and E. M. Ruttenstock
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Male ,medicine.medical_specialty ,Pediatrics ,Birth weight ,medicine.medical_treatment ,Congenital ,Extracorporeal Membrane Oxygenation ,Predictive Value of Tests ,Pregnancy ,Extracorporeal membrane oxygenation ,Humans ,Medicine ,Diaphragmatic hernia ,Hernias ,Retrospective Studies ,best oxygenation index ,diaphragmatic hernia ,mortality ,prognostic indices ,Biomarkers ,Female ,Fetal Therapies ,Hernias, Diaphragmatic, Congenital ,Infant ,Logistic Models ,Oxygen ,Prognosis ,ROC Curve ,Respiratory Function Tests ,Pediatrics, Perinatology and Child Health ,Surgery ,Univariate analysis ,business.industry ,Obstetrics ,Congenital diaphragmatic hernia ,Gestational age ,Retrospective cohort study ,Perinatology and Child Health ,medicine.disease ,Predictive value of tests ,business ,Diaphragmatic - Abstract
Aim of the Study Severe lung hypoplasia and persistent pulmonary hypertension are the main determining factors of survival in infants with congenital diaphragmatic hernia (CDH). The oxygenation index (ratio of delivered oxygen and its arterial level) closely reflects lung function. Single-institution studies have reported that best oxygenation index on day 1 of life (BOI-d1) is the most reliable postnatal predictor of survival in CDH. The aim of this study was to evaluate the predictive value of BOI-d1 in four disparate high volume centers in Europe. Methods A retrospective, multicenter study of infants with CDH born between 2000 and 2009 in four European tertiary institutions was conducted. Ethical approval was obtained from institutional review boards. Centers no. 1 and. 4 offered extracorporeal membrane oxygenation (ECMO), whereas center no. 3 offered fetal endoluminal tracheal occlusion (FETO) in fetuses defined as poor prognosis (lung-to-head ratio [LHR] ≤ 1.0 and “liver-up” position). Prenatal LHR and perinatal variables, including gestational age, birth weight, defect side, liver position, BOI-d1, and patch requirement, were analyzed. Receiver operating characteristic curves were used to determine cutoff values for continuous variables. Comparison was made between survivors and nonsurvivors using univariate analysis and logistic regression analysis, p Results A total of 235 infants (center no. 1, n = 29; no. 2, n = 64; no. 3, n = 113; and no. 4, n = 29) were included. One infant required (2%) ECMO and 66 (28%) had FETO. LHR was available in 83 patients (36%). Overall survival (discharge from hospital) and 28-day survival were 67.6% (n = 159) and 72.3% (n = 170), respectively. Univariate analysis showed that significant categorical predictors of 28-day survival were liver-down position (p 1 (p = 0.003), and primary repair (p = 0.02) but not defect side (p = 0.83). Area under the receiver operating characteristic (AUROC) curve for continuous variables; gestational age, birth weight, and BOI-d1 were 0.70, 0.68, and 0.88, respectively. AUROC for BOI-d1 (28-day survival) was 0.91 and had sensitivities (73 and 91%) and specificities (92 and 80%) for cutoffs of 40 and 82, respectively. Conclusion This multicenter study showed, that except from the defect side, all the prenatal variables studied have predictive value but the most useful is BOI-d1. This is simple to calculate and represents an excellent marker for lung function and a reliable early postnatal predictor of survival.
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- 2015
26. [Nissen fundoplication in children under 1 year of age: is age important?]
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Mi, Romo, López-Fernández S, Núñez V, Mv, Amesty, Triana P, Domínguez E, Ca, La Torre, Barrena S, López-Santamaría M, and Martínez L
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Male ,Reoperation ,Age Factors ,Infant, Newborn ,Fundoplication ,Infant ,Postoperative Complications ,Treatment Outcome ,Child, Preschool ,Humans ,Female ,Laparoscopy ,Follow-Up Studies ,Retrospective Studies - Abstract
Nissen fundoplication (NF) is a procedure with technical difficulties and variable functional prognosis the lower the patient's age is. Our objective is to analyze the peculiarities of this procedure when performed in children under 1 year.Retrospective study of the NF in our center from 1999 to 2014. We review the differences between children under 1 year of age and the leftover of the series: history, indications, surgical approach and postoperative outcomes.A total of 233 patients (57.1% male) were operated at a median age of 2.3years (1 month-17.31years), of which 82 (35.2%) were younger than 1 year. It Open surgery was performed in 118 patients (86.6% of children under 1 year and 31.1% over 1 year, p0.05) and laparoscopic in 115. The median follow-up was 3.92 ± 3.24 years. Patients under 1 year had a higher number of comorbidities (91.5% vs 81.5%), respiratory symptoms (76.8% vs 49.7%) and postoperative complications (20.7% vs 9.9% OR = 2.4), with statistically significant differences (p0.05). There were not differences in the Nissen's failure rate (15.9% vs 8.6%) or the need of reoperation (15.9% vs 7.9%).Patients under 1 year operated by NF form a group with particular indications and comorbidities. Although the outcomes among these patients are favourable, surgical complications are more frequent than in older children.La funduplicatura de Nissen (FN) es un procedimiento que plantea dificultades técnicas y un pronóstico funcional variable cuanto menor es la edad del paciente. Nuestro objetivo es analizar las peculiaridades de esta intervención cuando se realiza a niños menores de 1 año.Estudio retrospectivo de las FN en nuestro centro de 1999 a 2014. Se evaluaron las diferencias entre menores de 1 año de vida y el resto de la serie en cuanto a antecedentes, indicaciones, abordaje quirúrgico y evolución postoperatoria.Un total de 233 pacientes (57,1% varones) fueron intervenidos a una mediana de edad de 2,3 a (1 mes-17,31 a), de los que 82 (35,2%) eran menores de 1 año. La cirugía fue abierta en 118 pacientes (86,6% de los menores de 1 año y 31,1% de los mayores de 1 año, p0,05) y laparoscópica en 115. La mediana de seguimiento fue de 3,92 años. Los pacientes menores de 1 año presentaron mayor número de comorbilidades (91,5% vs 81,5%), sintomatología respiratoria (76,8% vs 49,7%) y complicaciones postoperatorias (20,7% vs 9,9%, OR=2,4), siendo estas diferencias estadísticamente significativas (p0,05). No hubo diferencias en cuanto al fallo del Nissen (15,9% vs 8,6%) ni a la necesidad de reintervención (15,9% vs 7,9%).Los pacientes menores de 1 año operados mediante FN constituyen un grupo con indicaciones y comorbilidades particulares. Aunque los resultados son favorables, las complicaciones quirúrgicas son más frecuentes.
- Published
- 2017
27. STUDY OF BONE MARROW INFILTRATION AND MINIMUM RESIDUAL DISEASE (MRD) THROUGH FLOW CYTOMETRY (FC) IN PATIENTS WITH DIFFUSE LARGE B CELL LYMPHOMA (DLBCL)
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Baile, M., Barrena, S., Sancho, J. M., Grande, C., Fernandez, R., Batlle, A., Penarrubia, M. J., Penalver, F. J., Hernandez Rivas, J. A., Guinea, J. M., Perez, J. J., Vidriales, M. B., and Martin, A. A.
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- 2017
28. Ganglioneuroma: To Operate or Not to Operate
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Leopoldo Martinez, Sergio Lopez-Fernandez, Alejandra Vilanova-Sanchez, Barrena S, Manuel López-Santamaría, Purificación García, Juan A. Tovar, Alba Sanchez-Galan, and Sara Hernández A. Martín
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Male ,medicine.medical_specialty ,Abdominal pain ,Neoplasm, Residual ,Adolescent ,Stridor ,Horner syndrome ,Asymptomatic ,Diagnosis, Differential ,Postoperative Complications ,Risk Factors ,Cause of Death ,medicine ,Humans ,Ganglioneuroma ,Retrospective Studies ,Anisocoria ,Urinary retention ,business.industry ,Thoracic Neoplasms ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Survival Rate ,Bowel obstruction ,Italy ,Head and Neck Neoplasms ,Abdominal Neoplasms ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business - Abstract
Introduction Ganglioneuroma (GN) is a benign, differentiated variety of neurogenic tumor. It is often asymptomatic and may be diagnosed by serendipity. Surgical removal is the treatment of choice. However, it has been suggested that postoperative complications and sequelae might outweigh the benefits of this approach. The purpose of the present study was to examine these issues in a large experience of neural tumors. Methods Patients treated between 1992 and 2012 were retrospectively reviewed. Modern imaging, measurement of catecholamine metabolite excretion and metaiodobenzylguanidine were used for workup. Surgical treatment aimed at complete resection. Complications and sequelae were recorded. Literature was searched for regrowth or malignant transformation of GN. Results Of 227 patients with neural tumors, 24 were GN patients (12 abdominal, 11 thoracic and 1 cervical with 8 dumbbell extensions). Six children were symptomatic (three with abdominal pain and mass, one with stridor or dysphonia, and one each with anisocoria and opsomyoclonus). However, 18 (75%) were asymptomatic and the diagnosis was incidental. Several tumors were large and involved more than one body space. There were no neurologic symptoms in eight cases with dumbbell extension. Complete resection was achieved in 20 children (83%) whereas gross residual was left in four. Postoperative complications were: Horner syndrome (3 patients), mild scoliosis (1 patient), adhesive bowel obstruction (1 patient) and acute urinary retention (1 patient). There was no evidence of either regrowth or malignant behavior in residual masses left in place after follow-up of 84 (1–194) months. Conclusions There were a limited number of general minor complications in this series that did not include cases of regrowth or malignant transformation. However, these unfavorable events were occasionally reported in the literature. Since diagnosis of GN cannot be ascertained before removal of the mass, this should remain the aim of the treatment, although limiting the chances of complications to a minimum even if incomplete resection is the price to pay. Nonoperative attitudes should not be recommended in all cases, but they are certainly justified in some.
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- 2013
29. Erratum: Automated pattern-guided principal component analysis vs expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: a step forward in the standardization of clinical immunophenotyping
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Costa, E S, Pedreira, C E, Barrena, S, Lecrevisse, Q, Flores, J, Quijano, S, Almeida, J, del Carmen García-Macias, M, Bottcher, S, Van Dongen, J J M, and Orfao, A
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- 2011
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30. Liver Transplantation in Children with Cystic Fibrosis: Experience in our Centre and Preliminary Results with a Combined En Bloc Liver-Pancreas Graft
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Barrena S, Manuel López-Santamaría, Francisco Hernandez, Paloma Jara, Jose Luis Encinas, Sergio Lopez-Fernandez, Juan A. Tovar, M. Miguel, Ane M. Andres, M. Ramírez, Esteban Frauca, and Loreto Hierro
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Male ,medicine.medical_specialty ,Adolescent ,Cystic Fibrosis ,medicine.medical_treatment ,Liver transplantation ,Pancreas transplantation ,Cystic fibrosis ,Liver disease ,Liver Function Tests ,medicine ,Humans ,Child ,Exocrine pancreatic insufficiency ,business.industry ,Immunosuppression ,medicine.disease ,Survival Analysis ,Liver Transplantation ,Surgery ,Transplantation ,Treatment Outcome ,surgical procedures, operative ,Respiratory failure ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,Pancreas Transplantation ,business - Abstract
Aim of the study Cystic fibrosis (CF) is a multisystemic disease, with some patients developing end-stage liver disease (ESLD), requiring liver transplantation (LT). These children usually present with severe mutations of the CFTR gene. Almost 100% of patients with severe mutations develop exocrine pancreatic insufficiency, leading later to endocrine insufficiency. Immunosuppression accelerates the development of insulin-dependent diabetes (IDD) in transplanted children with CF. Our aims were: 1) to analyze our experience with CF-related ESLD children who received LT, and the relationship to the development of IDD; 2) to report our preliminary results with en bloc liver-pancreas transplantation (CLPT). Methods 9 children (6M/3F) with CF and ESLD underwent LT between 1993 and 2010; median age and weight were 12.3 years (range: 5.4–17.0) and 36.7 kg (range: 14.2–58.5), respectively. 4 patients received a whole graft, 4 had reduced grafts (1 split) and 1 underwent CLPT. Immunosuppression followed the protocols at the time of transplantation. Results Liver function was restored in all patients and none of them needed re-transplantation. Median follow-up was 105 months (range: 4–206). 1 child died of respiratory failure at 23 months after transplantation while awaiting pulmonary transplantation. Survival (Kaplan-Meier) at 105 months was 87.5%. 4 children already had IDD before transplantation and 3 developed diabetes immediately after transplantation. 2 had not developed IDD at the end of the study: the youngest at the time of LT (5.4 years, follow-up 7.1 years) and the girl who had had CLPT and who recovered normal exocrine and endocrine pancreatic function after transplantation. Conclusions LT is a realistic option to treat CF-related ESLD children. IDD is common in these patients. En bloc liver-pancreas transplantation is an appealing option, since it simultaneously restores exocrine function and prevents IDD. This procedure has clear technical advantages over simultaneous isolated liver and pancreas transplantation.
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- 2011
31. Late Surgery for Spinal Deformities in Children Previously Treated for Neural Tumors
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M. Ramírez, Barrena S, Luis Lassaletta, C de la Torre, F S Pérez-Grueso, Mario Díaz, Juan A. Tovar, Marta Miguel, and Martínez L
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Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Arthrodesis ,Kyphosis ,Scoliosis ,Laminotomy ,Neuroblastoma ,Postoperative Complications ,medicine ,Deformity ,Humans ,Child ,Retrospective Studies ,Rib cage ,Spinal Neoplasms ,business.industry ,Incidence ,Infant ,Laminectomy ,Ganglioneuroma ,medicine.disease ,Surgery ,Radiation therapy ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,medicine.symptom ,business - Abstract
Background/aim Surgery for neural tumors occasionally involves opening of the neural canal and/or costovertebral resection that may be followed by radiotherapy. Spinal deformities (SD) may occur in these cases. This study investigated the incidence, surgical indications and results of repair of late SD in a large series of patients with neural tumors. Methods A retrospective review of neural tumors treated between 1991 and 2009 at our institution identified children with SD who subsequently required spinal surgery. SD was meaÂ-sured using Cobb's angle. Instrumentation of the spine was indicated in patients with a Cobb's angle of more than 60° or rapidly progressing SD. The operation was adapted to the location, type and degree of SD. Patients were followed up and the remaining deviations were measured annually. Results Out of a series of 188 patients with neural tumors, 5 of 173 patients with neuroblastomas/ganglioneuromas (NB/GN) and 3 of 15 patients with PNET/Askin tumors developed SD over time. NB/GN children had intraspinal tumors requiring laminotomy (n=3) or laminectomy (n=2). PNET/Askin tumor patients had undergone largescale rib and partial vertebral body resection and radiotherapy. Scoliosis or kyphosis were located in the thoracic spine in 4, in the thoracolumbar spine in 3 and in the cervicothoracic spine in 1. The median preoperative Cobb's angle was 65° (50°-90°) prior to spinal surgery performed 2.9 (0.4-11) years after tumor removal. 3 growth bars, 2 vertical expandable prosthetic titanium ribs, 1 pediatric ISOLA device and anterior instrumentation were used. Arthrodesis was necessary in 3 patients. Median post-instrumentation deformity after 3.1 (0.2-12.2) years was 40° (20°-50°), giving an improvement of 38.4%. Conclusions With increasing numbers of children surviving cancer, attention must focus on sequelae. A sizeable number of survivors of NB/GN and PNET/Askin tumors develop serious SD requiring surgical correction. Pediatric surgeons, patients and relatives must be aware of these possible sequelae.
- Published
- 2011
32. Cephalic Pancreaticoduodenectomy for Bleeding Duodenal Arteriovenous Malformation
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Barrena S, E Domínguez, Ruben Ortiz, Leopoldo Martinez, Emilio Burgos, Juan A. Tovar, and Gerardo Prieto
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Gastrointestinal bleeding ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Vascular malformation ,lcsh:RJ1-570 ,lcsh:Surgery ,arteriovenous malformation ,gastrointestinal bleeding ,Arteriovenous malformation ,lcsh:Pediatrics ,lcsh:RD1-811 ,medicine.disease ,Pancreaticoduodenectomy ,Article ,Surgery ,vascular malformation ,Medicine ,Upper gastrointestinal bleeding ,pancreaticoduodenectomy ,business - Abstract
Introduction Treatment of recurrent severe gastrointestinal bleeding due to arteriovenous malformations may require complex resections. In some particular locations, extensive surgery is the only way out, as shown in this report. Case Report A 2.5-year-old child suffered repeated episodes of upper gastrointestinal bleeding since the first month of life. After an extensive diagnostic workout, the diagnosis of duodenal arteriovenous malformation was established. Cephalic pancreaticoduodenectomy with pyloric preservation was performed and no further episodes of bleeding occurred in the ensuing 2 years. Conclusion Bleeding malformations located in the pancreaticoduodenal area can be effectively treated in children by pylorus-preserving cephalic pancreaticoduodenectomy.
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- 2014
33. Assessment of Bone Marrow Infiltration and Minimal Residual Disease by Multidimensional Flow Cytometry in Patients With Diffuse Large B-Cell Lymphoma (DLBCL)
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Baile, Mónica, primary, Barrena, S., additional, Sancho, J.M., additional, Grande, C., additional, Fernández, R., additional, Batlle, A., additional, Peñarrubia, M.J., additional, Peñalver, F.J., additional, Hernández-Rivas, J.A., additional, Guinea, J.M., additional, Pérez, J.J., additional, Vidriales, M.B., additional, and Martín, A., additional
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- 2017
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34. Is Intraoperative Fluoroscopy Necessary for Central Venous Port System Placement in Children?
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Dore, Mariela, Barrena, S., Junco, Paloma Triana, Galán, Alba Sánchez, Gomez, Javier Jimenez, Martinez, Leopoldo, Triana Junco, Paloma, Sánchez Galán, Alba, and Jimenez Gomez, Javier
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FLUOROSCOPY , *RADIATION exposure , *JUGULAR vein , *STATISTICAL correlation , *CATHETERIZATION , *CONFIDENCE intervals , *HUMAN body , *ELECTROCARDIOGRAPHY , *INTRAOPERATIVE monitoring , *LONGITUDINAL method , *RADIATION doses , *SURGICAL therapeutics , *ULTRASONIC imaging , *CENTRAL venous catheterization - Abstract
Introduction: Central venous port (CVP) placement is traditionally performed under fluoroscopy guidance. However, efforts for radiation dose reduction in children have allowed the introduction of ultrasound guidance (USG) and anatomic landmarks as an alternative technique for CVP placement. The aim of this study is to determine whether intraoperative fluoroscopy (IF) is required to confirm the correct position of the catheter tip in children.Patients and Methods: A prospective, single-center study was performed between July and December 2017. Standard venous access site was the right internal jugular vein under USG. Estimated catheter length (ECL) was measured using anatomic landmarks. Ideal catheter length (ICL) was measured after placement under fluoroscopy guidance in the same patient. Age, sex, radiation dose, and complications were also analyzed. A t-test for paired samples and intraclass correlation coefficient were performed to analyze results.Results: A total of 30 consecutive patients aged 7 ± 2 years underwent CVP placement. The mean ECL was 17.1 ± 1.8 cm, while the mean ICL was 17.7 ± 1.8 cm. The mean difference between measurements was 0.28 cm (95% confidence interval [CI], -0.29 to 0.86; p = 0.324). Intraclass correlation coefficient analysis showed an agreement of 0.95 (95% CI, 0.91-0.98) between measurements. Mean radiation exposure during the procedure was 1.060.78 mGym2 during 0.34 ± 0.6 minutes. There were no complications registered during CVP placement.Conclusion: The correlation between IF and USG and anatomically guided catheter tip placement is optimal. These results suggest that fluoroscopy and the radiation exposure it entails can be safely avoided in selected children. [ABSTRACT FROM AUTHOR]- Published
- 2019
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35. Reliability of the Hirschsprung-Associated Enterocolitis Score in Clinical Practice.
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Dore, Mariela, Sanchez, Alejandra Vilanova, Junco, Paloma Triana, Barrena, S., De Ceano-Vivas, María, Gomez, Javier Jimenez, Moreno, Ane M. Andres, Santamaria, Manuel Lopez, Martinez, Leopoldo, Vilanova Sanchez, Alejandra, Triana Junco, Paloma, Jimenez Gomez, Javier, Andres Moreno, Ane M, and Lopez Santamaria, Manuel
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ENTEROCOLITIS ,CLERGY ,PEARSON correlation (Statistics) ,HIRSCHSPRUNG'S disease ,ANTIBIOTICS ,DIARRHEA ,LENGTH of stay in hospitals ,RESEARCH evaluation ,RISK assessment ,RETROSPECTIVE studies ,SEVERITY of illness index ,DISEASE complications - Abstract
Introduction: There is a lack of an agreed Hirschsprung-associated enterocolitis (HAEC) definition. In 2009, a HAEC score was proposed for the diagnosis of HAEC episodes. Our aim was to apply the HAEC score on HAEC episodes to determine its diagnostic efficiency and whether it correlated to its severity.Methods: Retrospective study of patients with HAEC admitted between 2000 and 2016. Episodes of HAEC were identified and the HAEC score was calculated. A cut-off of ≥ 10 according to Pastor et al and ≥ 4 according to Frykman et al were used. A Pearson's correlation coefficient was performed for outcome variable: length-of-stay (LOS).Results: Note that 21/93 (22.6%) patients with Hirschsprung's disease presented 50 HAEC episodes with a median of 2 (1-5) episodes during an 8.3-year (2-15.6) follow-up. The most common symptoms were foul-smelling (86% [43/50]) and explosive (60% [30/50]) diarrhea. Physical findings showed a distended abdomen (76% [38/50]) and fever (60% [30/50]) with dilated bowel (82% [41/50]) and rectosigmoid cut-off (80% [40/50]) identified on X-rays. Only 34% (17/50) showed abnormal laboratory findings. Patients were admitted with a median LOS of 7 days (1-28). A HAEC score of 9 (2-16) was found, and only 50% (25/50) of patients met the initial criteria (score of 10 points). However, the use of a 4-point cut-off would have allowed the diagnosis of 98% (49/50) of the patients. A positive linear correlation was found for LOS and HAEC score (r = 0.3, p = 0.014).Conclusion: There is no standardized definition for HAEC. The initial HAEC score cut-off is restrictive and might fail to identify milder episodes. The positive correlation with LOS and thus HAEC severity might aid in patient information and anticipation of treatment. [ABSTRACT FROM AUTHOR]- Published
- 2019
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36. High-Risk Hepatoblastoma: Results in a Pediatric Liver Transplantation Center
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C de la Torre, Murcia J, P Garcia-Miguel, Ane M. Andres Moreno, Felipe Hernández, Leopoldo Martinez, Manuel López-Santamaría, Gámez M, Leal N, Juan A. Tovar, Marta Miguel, Barrena S, and Jose Luis Encinas
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Hepatoblastoma ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Liver transplantation ,Severity of Illness Index ,Risk Factors ,Severity of illness ,medicine ,Humans ,Neoplasm Invasiveness ,Stage (cooking) ,Neoplasm Staging ,Retrospective Studies ,Chemotherapy ,business.industry ,Liver Neoplasms ,Retrospective cohort study ,medicine.disease ,Liver Transplantation ,Lymphoma ,Surgery ,Transplantation ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,business - Abstract
AIM Aim of the study was assess the results of the treatment of High-Risk Hepatoblastoma (HRH) in a tertiary center where all liver surgery facilities, including pediatric transplantation (LT), are available. METHODS 91 primary liver tumors treated between 1991 and 2009 were retrospectively reviewed. HRHs as defined by the SIOP criteria (PRETEXT IV or any stage with venous involvement, extrahepatic disease, tumor rupture and
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- 2010
37. Variant Techniques for Liver Transplantation in Pediatric Programs
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Paloma Jara, Juan A. Tovar, M. Gamez, Barrena S, Felipe Hernández, Ane M. Andres, Leal N, Manuel López-Santamaría, Murcia J, L Burgos, and Jose Luis Encinas
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medicine.medical_specialty ,Hepatoblastoma ,Adolescent ,Waiting Lists ,medicine.medical_treatment ,Liver transplantation ,Living donor ,Biliary atresia ,Living Donors ,Humans ,Medicine ,Child ,Survival analysis ,Hemochromatosis ,Retrospective Studies ,business.industry ,Graft Survival ,Infant ,Retrospective cohort study ,Organ Size ,medicine.disease ,Survival Analysis ,Liver Transplantation ,Surgery ,Treatment Outcome ,Spain ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Graft survival ,business - Abstract
Introduction Several variant techniques have been developed as alternatives to whole liver transplantation to improve size matching, timing, or simply to increase the pool of donors. The aim of this study was to assess the requirements of these techniques and their outcomes in a pediatric transplant program. Patients and method A retrospective analysis of children on the waiting list in the last 4 years was carried out. Data of patients who died while on the waiting list (WL) were recorded. Transplanted patients were divided according to the type of graft: whole liver, split, living donor and reduced liver. The analyzed outcome variables were: age, weight, UNOS status, cause of liver failure, complications and graft and patient survival. Comparisons between types of graft were performed by using Kaplan-Meier, log-rank, chi (2) and Kruskal-Wallis tests. Results During the period studied, 116 children were listed for liver transplantation. Of these 116 children, nine (7.7 %) died after a mean period of 40.5 (5-175) days waiting for a suitable graft. Their median age at inclusion was 214 (35-1607) days, and median weight was 7.2 (12.3-3.6) kg. The cause of liver failure in this group was: 1 hemochromatosis, 1 hepatoblastoma, 2 biliary atresia, 2 acute liver failure, 2 primary non-function (PNF) and 1 chronic rejection. Liver transplantation was performed in 103 children: 25 (24 %) whole livers, 17 (16.5 %) split, 29 (28 %) living donor, 32 (31 %) reduced and 4 remain on the waiting list. Recipient age and weight were significantly lower in those receiving split and living donor than in those who given whole livers. Patient and graft survival were similar in all groups although there was a trend to lower graft survival in patients receiving whole livers. More than 50 % of patients with UNOS status I received a split graft and 5/6 children with hepatoblastoma underwent living donor transplantation. There were no differences in the rate of acute vascular complications, but long-term biliary complications were more frequent in split and living donor grafts. Conclusions As long as the goal of zero mortality for children on the waiting list is not achieved, variant techniques will be necessary in pediatric liver transplantation programs. Split and living donor were employed mostly to treat younger children and particularly those with a higher UNOS status. Children with tumors were treated mainly with living donor grafts. Variant techniques, which are absolutely necessary in a pediatric program, need to be improved in order to avoid long-term biliary complications.
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- 2008
38. [Technical aspects of experimental intestinal transplant]
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López-Fernández S, Hernández F, Hernández-Martín S, Barrena S, Wang Z, Zou W, Am, Andrés, Jl, Encinas, Garriboli M, Carlota Largo, López-Santamaría M, and Ja, Tovar
- Subjects
Intestines ,Rats, Inbred BN ,Models, Animal ,Animals ,Organ Transplantation ,Rats, Wistar ,Rats - Abstract
Our objective is to analyze the variables that influence the outcome of Small Bowel Transplantation (SBT) in rats in an experimental microsurgery program. The surgical technique and perioperative care are described in detail.Retrospective study of the SBT in rats conducted in our experimental surgery laboratory from 2002 to 2010. The animals were divided into group A (those who survived more than 48 hours) and group B (those who died earlier without justificable cause). We compared in both groups: number of transplants performed by the surgeon, warm ischemia time, cold ischemia time and duration of the procedure.Five surgeons with different degrees of microsurgical training participated in the study. A total of 521 SBT were performed with an overall survival of 48%. The first successful transplant was performed after a median of 46 (25-68) transplants. Total procedure time (3.5 vs 2.9 hours) and warm ischemia time (51 vs 35 minutes) were higher in group B (p0.05).The number of transplants required for learning the technique is high. However, survival is acceptable when the time needed for vascular anastomosis is reduced. The SBT in rats is a valuable model for surgical training and research of the phenomena related to SBT.
- Published
- 2012
39. [Noninvasive positive pressure ventilation in postoperative period of tracheal surgery]
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Ca, La Torre, Hernández F, Sanabria P, Vázquez J, Miriam Miguel-Ferrero, Al, Luis, Barrena S, Aguilar R, Ramírez M, Hernández S, Borches D, Lassaletta L, and Ja, Tovar
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Male ,Positive-Pressure Respiration ,Postoperative Care ,Trachea ,Child, Preschool ,Humans ,Infant ,Female ,Child ,Retrospective Studies - Abstract
Reconstructive surgery of the airway often means prolonged periods of intubation during the post-operatory period, increasing the needs for drugs and favoring the appearance of infectious complications. We present an original system of ventilatory support with non-invasive positive pressure ventilation (NIPPV) using in patients subjected to reconstructive surgery of the airway.A retrospective study in patients undergoing reconstructive procedures of the airway in the year 2009 was carried out. We exclude those treated endoscopically and those who had vascular rings. The positive pressure mechanism used in the Surgery Critical Care Unit was a design made by the unit based on the circuit devised by Mapleson that provides optimum levels of ventilation without need for connection to a respiratory. We analyze the results, postoperatory intubation time, time dependent on NIPPV and medical treatment received.A total of 7 patients (1 Female and 6 Males) with median age of 1.6 (0.1-7.5) years were included. The diagnoses were: 4 subglottic stenosis, 2 had tracheal stenosis and 1 subcarinal stenosis with involvement of both principal bronchioles. The techniques used were: laryngotracheoplasty with costal cartilage graft (4), tracheoplasty with costal cartilage (1) and sliding tracheoplasty (2) with bilateral bronchoplasty in one of them. The mean time of nasotracheal intubation was 3 days, and mean time of NIPPV was 2.3. No patient required reintubation and none had infectious complications.Ventilatory support by VPPNI allows effective extubation in these patients, it being possible to maintain a safe airway. Infectious complications, frequent in prolonged intubations, were not observed in any of the cases.
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- 2011
40. [Bean or blue rubber blue nevus syndrome. Presentation of 6 patients]
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Ramírez M, Jc, López Gutiérrez, Diaz M, Soto C, Miriam Miguel-Ferrero, Ca, La Torre Ramos, Barrena S, Ros Z, and Ja, Tovar
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Male ,Skin Neoplasms ,Child, Preschool ,Nevus, Blue ,Humans ,Infant ,Female ,Child ,Gastrointestinal Neoplasms ,Retrospective Studies - Abstract
Bean or Blue Rubber Bleb Nevus Syndrome (BRBNS) is an uncommon disease characterized by multifocal venous malformations that predominantly affect the skin, soft tissues and gastrointestinal tract. Our objective is to familiarize the pediatric surgeon with this condition, promoting early diagnosis and seriated surgical treatment as therapeutic options. We have reviewed the diagnosis and treatment of 6 patients treated from 1993 to 2009.All the patients had a venous malformation (10 cm) that acted as a marker. After, characteristic skin lesions appeared as well as chronic anemia due to digestive bleeding associated to hypofibrinogenemia. Age of appearance of the anemic picture varied from 6 months to 7 years, it being more aggressive the earlier its appearance. The diagnosis of the disease was made by endoscopically. All the patients required transfusion with blood derivatives 5 to 25 times a year. Treatment was multidisciplinary: periodic transfusions in every case, endoscopic sclerosis in lesions that affect the colon or stomach and surgical treatment for lesions of the jejunum and ileum. In two of these patients, 23 and 46 lesions were excised, respectively. In the last year, the tendency has been to use enterotomy and fulguration with Argon.The patients who have undergone excision of the digestive malformations have experienced a significant decrease in their transfusion needs. One female patient with miliary dissemination died.BRBNS is a difficult to diagnose due to its low frequency. Treatment of gastrointestinal tract lesions is multidisciplinary, combining endoscopic and surgical techniques that decrease transfusions and improve the quality of life of the patients.
- Published
- 2011
41. [Chronic idiopathic intestinal pseudoobstruction and Berdon syndrome: still a diagnostic and therapeutic challenge for the pediatric surgeon]
- Author
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Am, Andrés, Miriam Miguel-Ferrero, De la Torre C, Barrena S, Ramírez M, Hernández F, Martínez L, Leal N, Ramos E, Prieto G, López Santamaría M, and Ja, Tovar
- Subjects
Male ,Colon ,General Surgery ,Chronic Disease ,Intestinal Pseudo-Obstruction ,Urinary Bladder ,Humans ,Infant ,Abnormalities, Multiple ,Female ,Pediatrics ,Follow-Up Studies ,Retrospective Studies - Abstract
Chronic Intestinal Pseudo Obstruction (CIPO) and Berdon Syndrome (BS) are motility disorders with still unclear pathophysiology, and challenging diagnosis and management. Patient and methods. 26 patients (8M/18F) treated of CIPO (21) or BS (5) at our institution between 1982-2009 were retrospectively reviewed and clinical, diagnostic, therapeutic and follow-up data were analyzed.77% had a neonatal onset by the 3rd month of life (5 had a prenatal diagnosis of megacystis). Abdominal distension (87%), recurrent suboclusive episodes (70%) and malnourishment (60%) were the main symptoms followed by vomits, chronic diarrhea, constipation and dysfagia. The urinary tract was involved in 12 patients (46%): 8 had megacystis, 8 had vesicoureteral reflux. Arrythmias were seen in 2, deafness in 1, hydrocephalia in 1 and malrotation in 5. Radiological studies were consistent for CIPO in all of them: the disease was limited to the esophagus in 1, 3 had segmentary involvement of the small bowel, 6 had microcolon, and the rest had all the digestive tract involved. Anorectal manometry ruled out aganglionosis in 12, esophageal manometry showed aperistalsis in 9 and antro-duodenal manometry confirmed the diagnosis in 9 (visceral myopathy in 4 y neuropathy in 5). Rectal biopsies (16) and muscular biopsies (5) were normal in all of them. Full thickness biopsies (in 18, after surgery) showed myopathy in 12 and neuropathy in 6. Prokinetics and antibiotics for bacterial overgrowth were employed in 100%, 17 required long-time parenteral nutrition (PN), 21 required surgery and 7 were transplanted (4 isolated small bowel, 3 multivisceral). Symptoms improved in 9/15 with an ileostomy. 19 weaned from PN. After a median follow-up of 7.9 years (range 5m-17a), 3 were lost, 17/23 patients are alive and only 2 on home PN. Six died, 3 after being transplanted.CIPO and/or BS have a wide clinical spectrum and a complex diagnosis; however, the knowledge of the disease and an appropriate treatment, generally aggressive, allows the patients with CIPO to enjoy a long-term acceptable quality of life.
- Published
- 2011
42. Colonic interposition for esophageal replacement in children remains a good choice: 33-year median follow-up of 65 patients
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Barrena S, Leopoldo Martinez, Ane M. Andres, Francisco Hernandez, Luis Lassaletta, Juan A. Tovar, Olivares P, and L Burgos
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Adult ,Male ,medicine.medical_specialty ,Colon ,Scoliosis ,Anastomosis ,Gastroenterology ,Disease-Free Survival ,Young Adult ,Esophagus ,Quality of life ,Median follow-up ,Internal medicine ,medicine ,Humans ,Functional ability ,Longitudinal Studies ,Karnofsky Performance Status ,Child ,Esophageal Atresia ,Digestive System Surgical Procedures ,Retrospective Studies ,business.industry ,Anastomosis, Surgical ,Infant ,Retrospective cohort study ,General Medicine ,medicine.disease ,Surgery ,Trachea ,medicine.anatomical_structure ,Treatment Outcome ,Atresia ,Child, Preschool ,Esophagoplasty ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Female ,business ,Tracheoesophageal Fistula - Abstract
Introduction: Gastric pull-up has become the predominant technique for esophageal replacement because of allegedly deficient results of colon grafts. This retrospective study examines the long-term results in a large series of colonic interpositions. Patients and Method: One hundred six children (median, 2.9 years; range, 0.32-15 years) had their esophagus replaced between 1965 and 2008, of which 96 had colon grafts. Those survivors who were 18 years and older were contacted and, if willing, interviewed, examined, and had their functional ability rated using the Karnofsky index. Results: Ninety-six children had undergone a colon graft, and of these, 9 (9.3%) died. There were 65 long-term survivors whose indications for surgery included caustic injury (n = 32), failed tracheoesophageal fistula repair (n = 16), pure esophageal atresia (n = 14), and others (n = 3). The graft was either retrosternal (n = 49) or mediastinal (n = 16 patients). Twelve patients were unavailable for long-term assessment. After a median follow-up of 33.3 (11-41) years, 23 (43%) of 53 individuals experienced mild symptoms of reflux; scoliosis, 12 (22%) of 53, and/or other complications, 15 (27%) of 53 required further surgery. Thirty-two patients (60%) with Karnofsky indexes of 80% or higher felt healthy, 19 (36%) had mild life-style limitations (index, 40%-80%), and 2 had indexes less than 40%. Most patients live normal lives. Conclusions: Colon conduits restored gastrointestinal continuity with limited mortality and considerable morbidity but good functional outcome and health perception in the long-term. Our study suggests that colon grafts are no worse than gastric pull-ups in the long-term.
- Published
- 2009
43. Long-term results of the treatment of total colonic aganglionosis with two different techniques
- Author
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Francisco Hernandez, Martínez L, Manuel López-Santamaría, Ane M. Andres, Luis Lassaletta, L Burgos, Juan A. Tovar, Barrena S, and Luis Al
- Subjects
Adult ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Anastomosis ,Total Intestinal Aganglionosis ,Ileocecal valve ,Postoperative Complications ,Quality of life ,medicine ,Fecal incontinence ,Humans ,Hirschsprung Disease ,Child ,Total colonic aganglionosis ,Digestive System Surgical Procedures ,business.industry ,Infant ,Family life ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Defecation ,medicine.symptom ,business ,Fecal Incontinence ,Follow-Up Studies - Abstract
AIM: Aim of this study was to assess the long-term results of the treatment of total colonic aganglionosis (TCA) with 2 different techniques in terms of growth, continence and quality of life (QOL). PATIENTS AND METHODS: Forty-one patients treated for TCA between 1972 and 2007 were reviewed retrospectively with special attention paid to the length of aganglionosis, complications, growth, continence and QOL. Until 1992, patients underwent subtotal colonic resection and side-to-side ileosigmoid anastomosis (modified Martin). Since 1992, straight ileo-anal pull-through was preferred. At the end of follow-up (median 18 years, range 1-35), the height and weight, continence and QOL (scoring feeding habits, school/work performance, family life and professional development) were assessed by clinical visit or phone interview. RESULTS: Twenty-eight patients were male and 13 female. Six had total intestinal aganglionosis and were excluded from this review together with the 2 who died before definitive treatment. The 33/41 persons in whom aganglionosis had involved less than 50 cm above the ileocecal valve and who had been considered suitable for the reestablishment of transanal fecal flow were included. Eighteen children underwent a modified Martin and 15 straight ileo-anal pull-through. Postoperative intestinal obstruction occurred in 4 cases, prolapse and prolonged TPN requirement in 2, and wound disruption and fistula in 1. Thirteen patients (39 %) had postoperative enterocolitis. Two children died after operation (1 wound disruption with sepsis and 1 pneumonia). Out of 31 survivors, 57 % and 53 % were > p50 with regard to height and weight whereas only 15 % and 19 % were
- Published
- 2008
44. GORLÉE, Dinda L.: On Translating Signs. Exploring Text and Semio-Translation, Rodopi, Amsterdam, 2004, 250 págs. [RECENSIÓN]
- Author
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Barrena, S. F. (Sara F.)
- Published
- 2005
45. GIOVANNI, Maddalena (ed.), Scritti Scelti di Charles Sanders Peirce, Unione Tipografico-Editrice Torinese, Turín, 2005, 740 pp. [RECENSIÓN]
- Author
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Barrena, S. F. (Sara F.)
- Published
- 2005
46. Cephalic Pancreaticoduodenectomy for Bleeding Duodenal Arteriovenous Malformation
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Dominguez, Eva, primary, Barrena, S., primary, Martinez, Leopoldo, primary, Prieto, Gerardo, primary, Burgos, Emilio, primary, Tovar, Juan, primary, and Ortiz, Ruben, additional
- Published
- 2014
- Full Text
- View/download PDF
47. El Grupo de Estudios Peirceanos de la Universidad de Navarra
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Barrena, S. F. (Sara F.) and Nubiola, J. (Jaime)
- Abstract
In this report the history and main activities of the Grupo de Estudios Peirceanos at the University of Navarra is presented. It was created in 1994 to promote the study of the work of Charles S. Peirce (1839-1914), especially in Spain and in the Spanish-speaking countries. An outstanding result of the work of this group is the massive installment in the web of Peirce’s texts translated into Spanish.
- Published
- 2002
48. Sini, Carlo: El pragmatismo, Ediciones Akal, Madrid, 1999, 79 págs. [RECENSIÓN]
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Barrena, S. F. (Sara F.)
- Published
- 1999
49. Reseñas 32/2 (1999)
- Author
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Acosta, M. (Miguel), Ortiz-de-Landázuri, C. (Carlos), Sánchez-Migallón, S. (Sergio), Sierra, B. (Beatriz), García-Cuadrado, J.A. (José Ángel), Barrena, S. F. (Sara F.), Delgado, C. (Carolina), Arranz, C. L. (Cristina L.), and Falgueras-Salinas, I. (Ignacio)
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reseñas - Published
- 1999
50. Liver Transplantation in Children with Cystic Fibrosis: Experience in our Centre and Preliminary Results with a Combined En Bloc Liver-Pancreas Graft
- Author
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Miguel, M., additional, Andres, A.M., additional, Lopez-Santamaria, M., additional, Barrena, S., additional, Hierro, L., additional, Hernandez, F., additional, Ramírez, M., additional, Frauca, E., additional, Encinas, J.L., additional, Lopez-Fernandez, S., additional, Jara, P., additional, and Tovar, J.A., additional
- Published
- 2011
- Full Text
- View/download PDF
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