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1. AB0796 CANVASC CONSENSUS RECOMMENDATIONS FOR THE USE OF AVACOPAN IN ANTINEUTROPHIL CYTOPLASM ANTIBODY-ASSOCIATED VASCULITIS: 2022 ADDENDUM

Author

Turgeon, D., primary, Bakowsky, V., additional, Baldwin, C., additional, Cabral, D., additional, Clements-Baker, M., additional, Clifford, A., additional, Cohen Tervaert, J. W., additional, Dehghan, N., additional, Ennis, D., additional, Famorca, L., additional, Fifi-Mah, A., additional, Girard, L. P., additional, Lefebvre, F., additional, Liang, P., additional, Makhzoum, J. P., additional, Massicotte-Azarniouch, D., additional, Mendel, A., additional, Milman, N., additional, Reich, H., additional, Robinson, D., additional, Ross, C., additional, Rumsey, D. G., additional, Soowamber, M., additional, Towheed, T., additional, Trudeau, J., additional, Twilt, M., additional, Yacyshyn, E., additional, Yardimci, G., additional, Barra, L., additional, and Pagnoux, C., additional

Published
2023
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3. Disfunción de cuerdas vocales post tiroidectomía, reporte de un caso.

Author

Rocha A., Luis, Borel B., Claudio, and Barra L., Luis

Abstract

Copyright of Revista de Cirugia is the property of Sociedad de Cirujanos de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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4. Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Author

Monti, S., Craven, A., Klersy, C., Montecucco, C., Caporali, R., Watts, R., Merkel, P. A., Luqmani, R., Achilleos, K., Adler, M., Alba, M. A., Albert, D. A., Alibaz-Oner, F., Allcoat, P., Amano, K., Amarasuriya, M., Amudala, N. A., Andrews, J., Archer, A. M., Arimura, Y., Atukorala, I., Azevedo, E., Bajad, S., Baldwin, C., Barra, L. J., Baslund, B., Basu, N., Baykal, M., Berger, C., Berglin, E., Besada, E., Bhardwaj, M., Bischof, A., Blockmans, D., Blood, J., Draibe, J. B., Brand, S., Brandao, M., Bruce, I. N., Butler, A., Calabrese, L. H., Ferrer, D. C., Carette, S., Carmona, D., Ceunen, H., Chakravarty, K., Chapman, P. T., Chocova, Z., Chung, S. A., Ci, W., Cid, M. C., Clark, T. M., Clarkson, M. R., De Jesus Contreras-Rodriguez, F., Conway, R., Cooke, K., Viros, X. C., Cordeiro, A., Costa, A., Culfear, K., Daikeler, T., Danda, D., Das, S. K., Dasgupta, B., De Castro, A. M., Dehghan, N., Devassy, R., Dhindsa, N., Diamantopoulos, A. P., Direskeneli, H., Dobashi, H., Juan, D., Durrani, M., Edelsten, C., Eifert, J., Elhayek, S., Elsideeg, S., Endo, T., Erden, A., Erer, B., Eriksson, P., Erturk, Z., Espigol-Frigole, G., Felicetti, M., Ferraro, A., Ferro, J. M., Fifi-Mah, A., Flores-Suarez, L. F., Flossmann, O., Flynn, D., Fonseca, J. E., Foot, J., Foote, M., Forbess, L., Fujimoto, S., Fukuoka, K., Furtado, C., Furuta, S., Gaffo, A. L., Gallagher, P., Gao, N., Gatenby, P., Gendi, N., Geraldes, R., Gerits, A., Gioffredi, A., Gomples, L., Goncalves, M. J., Gondo, P., Graham, A., Grainger, R., Gray, D. T., Grayson, P. C., Griffiths, L., Guo, Y., Gupta, R., Gylling, M., Hajj-Ali, R. A., Hammam, N., Harigai, M., Hartley, L., Haslett, J., Hassan, A., Hatemi, G., Hellmich, B., Henckaerts, L., Henes, J. C., Hepburn, J., Herd, V., Hess, C., Hill, C., Hinojosa-Azaola, A., Hirahashi, J., Hirano, F., Hocevar, A., Holle, J., Hollinger, N., Homma, S., Howard, T., Hoyles, R. K., Hruskova, Z., Hutcheon, G., Ignacak, M., Igney-Oertel, A., Ikeda, K., Ikegaya, N., Jagadeesh, S., Jaquith, J., Jayne, D. R. W., Jewell, T., Jones, C., Joshi, A., Kalyoncu, U., Kamall, S., Kamath, S., Lai, K. S., Kaname, S., Kanchinadham, S., Karadag, O., Karube, M., Kaszuba, M., Kaur, R., Kawakami, T., Kawashima, S., Khalidi, N., Khan, A., Kikuchi, M., Kilic, L., Kimura, M., King, M. J., Klapa, S., Klocke, R., Kobayashi, T., Kobayashi, S., Komagata, Y., Kronbichler, A., Kuczia, P., Kumar, M. S., Kurosawa, M., Lamprecht, P., Langford, C. A., Lanyon, P., Laversuch, C., Lee, S. J., Leoni, S., Li, J., Liang, K., Liang, P., Liao, H., Lee, L. A., Luqmani, R. A., Lyle, A., Macdonald, M., Mackie, S. L., Madden, L., Magliano, M., Makino, H., Makol, A., Malaiya, R., Malaviya, A., Manthri, R., Maritati, F., Da Silva, A. M., Mason, J. C., Matara, C., Matsui, K., Matteson, E. L., Mcbride, D., Mccullough, K., Mcgeoch, L., Mclaren, J., Mcmillian, C., Mendiratta, N., Menon, A., Merinopoulos, D., Merkel, P., Messier, S., Micheletti, R. G., Mills, K., Milman, N., Minoda, M., Minz, R. W., Mock, C., Mohammad, A. J., Moiseev, S., Moitinho, M., Molloy, E., Monach, P. A., Montgomery, M., Moosig, F., Moradizadeh, M., Morgan, M., Morgan, A. W., Morgan, A. -M., Muir, A., Mukhtyar, C., Muller, A., Muratore, F., Muso, E., Nada, R., Nakajima, H., Nakajima, T., Nakano, H., Nandagudi, A., Neumann, T., Y. F., Ng, K. H., Ng, Nogueira, E. L., Nolkha, N., Nordstrom, D., Novikov, P., Nugaliyadde, A., O'Donnell, J. L., O'Donoghue, J., O'Neill, L., O'Riordan, E., Oatley, M., Okubo, K., Oliva, E., Oshikawa, H., Ota, Y., Padoan, R., Pagnoux, C., Pan, L., Panaritis, K., Park, J. K., Patel, S., Patil, P., Pazzola, G., Peall, A., Pearce, F., Pehlevan, S., Pereira, L., Pettersson, T., Pineau, C. A., Pirila, L., Poglodek, B., Ponte, C., Prieto-Gonzalez, S., Priya, S. R., Purewal, B., Purschke, S., Putaala, J., Quickert, S., Quincey, V., Raghuvanshi, S., Rajasekhar, L., Ranganathan, D., Rathi, M., Rees, D., Rees, F., Renken, U., Restuccia, G., Rhee, R. L., Rice, B., Robins, D., Robson, J., Rodrigues, M., Romao, V. C., Rotar, C., Ruediger, C., Rutgers, A., A. C., Sa, Saavedra, M. J., Sada, K. -E., Sahbudin, I., Salvarani, C., Sandhu, N., Santos, E., Sato, Y., Schafer, V. S., Schiavon, F., Schmidt, W. A., Segelmark, M., Shahin, A., Sharma, A., Shotton, J., Silva, C., Singer, O. G., Sivasuthan, G., Smolen, S., Solanich-Moreno, X., Boixader, L. S., Song, Y. W., Springer, J., Sreih, A. G., Srivastava, R., Stamp, L. K., Stevens, R., Strbian, D., Sugino, K., Sunderkotter, C., Suppiah, R., Suzuki, K., Szekanecz, Z., Sznajd, J., Taimen, K., Tak, P. P., Takeuchi, T., Takizawa, N., Tames, L., Tan, B. E., Tanaka, M., Tang, M. W., Tatlisumak, T., Tesar, V., Thomas, A., Tian, X., Tokunaga, K., Tombetti, E., Tomsic, M., Toz, B., Tsukamoto, T., Uchida, S., Unal, A. U., Urban, M. L., Usui, J., Vaglio, A., Venkatachalam, S., Vermaak, E., Viswanath, V., Wada, T., Wagh, S., Wallace, D. J., Walters, G., Walz, B., Wan, J., Wang, T., Wang, G., Warrington, K. J., Watts, R. A., Wawrzycka-Adamczyk, K., Weeratunga, P., Weisman, M. H., Wickramasinghe, S., Williams, M., Wojcik, K., Woodruff, L., Xenitidis, T., Yamada, H., Yamagata, K., Yee, C. -S., Yoon, M., Yoshida, K., Yoshifuji, H., Ytterberg, S. R., Yumura, W., Zayed, H., Zeng, X., Zhao, M. -H., Zugaj, A., Zuk, J., İç Hastalıkları, Clinical Haematology, and Translational Immunology Groningen (TRIGR)

Subjects
Male, Outcome, Antineutrophil Cytoplasmic, 030232 urology & nephrology, 0302 clinical medicine, Risk Factors, 80 and over, Pharmacology (medical), Age of Onset, Young adult, Aged, 80 and over, education.field_of_study, age, anti-neutrophil cytoplasmic antibody-associated vasculitis, outcome, Adolescent, Adult, Aged, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Antibodies, Antineutrophil Cytoplasmic, Female, Humans, Middle Aged, Morbidity, Prognosis, Retrospective Studies, Risk Assessment, Survival Rate, United Kingdom, Young Adult, Vasculitis, Systemic vasculitis, medicine.medical_specialty, Population, anti-neutrophil cytoplasmic antibody–associated vasculitis, Antibodies, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, education, Anti-neutrophil cytoplasmic antibody–associated vasculitis, Survival rate, Anti-neutrophil cytoplasmic antibody, 030203 arthritis & rheumatology, business.industry, Retrospective cohort study, medicine.disease, Age of onset, business
Abstract

Objectives ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- and older-onset patients are still incompletely understood. Methods We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: Results A total of 1338 patients with AAV were included: 66% had disease onset at Conclusion Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients.

Published
2021
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5. Identification of a green algal strain collected from the Sarno River Mouth (Gulf of Naples, Italy) and its exploitation for heavy metal remediation

Author

Barra, L., Sardo, A., Caballero, M.M., Smerilli, A., Chiaiese, P., Percopo, I., Cavalletti, E., Castro-Hinojosa, C., Balzano, S., Barra, L., Sardo, A., Caballero, M.M., Smerilli, A., Chiaiese, P., Percopo, I., Cavalletti, E., Castro-Hinojosa, C., and Balzano, S.

Abstract

Heavy metals (HMs) can induce both chronic and acute harmful effects on marine and freshwater biota. The environmental impact of HMs in freshwater, seawater, soil, and wastewater can be limited using microbes, including microalgae, that are able to remove metals from environmental matrices. Indeed, they can passively adsorb and actively accumulate these persistent pollutants within their organelles, limiting their detrimental effects on cellular metabolism. The Sarno River is a 30 km long freshwater stream located in Southern Italy, polluted by partially untreated municipal, agricultural, and industrial wastewaters. In spite of this, microalgal cultures from Sarno River or Sarno River Mouth have never been established. In the present study, we isolated a green algal strain from the Sarno River Mouth and determined its ability to grow in polluted seawater containing different concentrations of cadmium, lead, or zinc. This strain was found to be able to accumulate these elements within its biomass in a dose-dependent manner. Growth inhibition experiments confirm the relatively low toxicity of Cd and Pb below 50 µM, while algal growth was seriously affected in Zn-amended media. To the best of our knowledge, this is the first study focused on the ability of microalgae from Sarno River Mouth to tolerate and uptake HMs.

Published
2022

6. Copper effect on microalgae: Toxicity and bioremediation strategies

Author

Cavalletti, E., Romano, G., Palma Esposito, F., Barra, L., Chiaiese, P., Balzano, S., Sardo, A., Cavalletti, E., Romano, G., Palma Esposito, F., Barra, L., Chiaiese, P., Balzano, S., and Sardo, A.

Abstract

Microalgae are increasingly recognised as suitable microorganisms for heavy metal (HM) removal, since they are able to adsorb them onto their cell wall and, in some cases, compartmentalise them inside organelles. However, at relatively high HM concentrations, they could also show signs of stress, such as organelle impairments and increased activities of antioxidant enzymes. The main aim of this review is to report on the mechanisms adopted by microalgae to counteract detrimental effects of high copper (Cu) concentrations, and on the microalgal potential for Cu bioremediation of aquatic environments. Studying the delicate balance between beneficial and detrimental effects of Cu on microalgae is of particular relevance as this metal is widely present in aquatic environments facing industrial discharges. This metal often induces chloroplast functioning impairment, generation of reactive oxygen species (ROS) and growth rate reduction in a dose-dependent manner. However, microalgae also possess proteins and small molecules with protective role against Cu and, in general, metal stress, which increase their resistance towards these pollutants. Our critical literature analysis reveals that microalgae can be suitable indicators of Cu pollution in aquatic environments, and could also be considered as components of eco-sustainable devices for HM bioremediation in association with other organisms

Published
2022

7. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis

Author

Grayson, P. C., Ponte, C., Suppiah, R., Robson, J. C., Craven, A., Judge, A., Khalid, S., Hutchings, A., Luqmani, R. A., Watts, R. A., Merkel, P. A., Gatenby, P., Hill, C., Ranganathan, D., Kronbichler, A., Blockmans, D., Barra, L., Carette, S., Pagnoux, C., Dhindsa, N., Fifi-Mah, A., Khalidi, N., Liang, P., Milman, N., Pineau, C., Tian, X., Wang, G., Wang, T., Zhao, M. -H., Tesar, V., Baslund, B., Hammam, N., Shahin, A., Pirila, L., Putaala, J., Hellmich, B., Henes, J., Lamprecht, P., Neumann, T., Schmidt, W., Sunderkoetter, C., Szekanecz, Z., Danda, D., Das, S., Gupta, R., Rajasekhar, L., Sharma, A., Wagh, S., Clarkson, M., Molloy, E., Salvarani, C., Schiavon, F., Tombetti, E., Vaglio, A., Amano, K., Arimura, Y., Dobashi, H., Fujimoto, S., Harigai, M., Hirano, F., Hirahashi, J., Honma, S., Kawakami, T., Kobayashi, S., Kono, H., Makino, H., Matsui, K., Muso, E., Suzuki, K., Ikeda, K., Takeuchi, T., Tsukamoto, T., Uchida, S., Wada, T., Yamada, H., Yamagata, K., Yumura, W., Lai, K. S., Flores-Suarez, L. F., Hinojosa, A., Rutgers, B., Tak, P. -P., Grainger, R., Quincey, V., Stamp, L., Besada, E., Diamantopoulos, A., Sznajd, J., Azevedo, E., Geraldes, R., Rodrigues, M., Santos, E., Song, Y. -W., Moiseev, S., Hocevar, A., Cid, M. C., Moreno, X. S., Atukorala, I., Berglin, E., Mohammed, A., Segelmark, M., Daikeler, T., Direskeneli, H., Hatemi, G., Kamali, S., Karadag, O., Pehlevan, S., Adler, M., Basu, N., Bruce, I., Chakravarty, K., Dasgupta, B., Flossmann, O., Gendi, N., Hassan, A., Hoyles, R., Jayne, D., Jones, C., Klocke, R., Lanyon, P., Laversuch, C., Luqmani, R., Robson, J., Magliano, M., Mason, J., Maw, W. W., Mcinnes, I., Mclaren, J., Morgan, M., Morgan, A., Mukhtyar, C., O'Riordan, E., Patel, S., Peall, A., Venkatachalam, S., Vermaak, E., Menon, A., Watts, R., Yee, C. -S., Albert, D., Calabrese, L., Chung, S., Forbess, L., Gaffo, A., Gewurz-Singer, O., Grayson, P., Liang, K., Matteson, E., Springer, J., Sreih, A., and Translational Immunology Groningen (TRIGR)

Subjects
Adult, Male, Vasculitis, Myeloblastin, Immunology, Churg-Strauss Syndrome, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Antibodies, Antineutrophil Cytoplasmic, Diagnosis, Differential, Rheumatology, Risk Factors, Humans, Immunology and Allergy, anti-neutrophil cytoplasm antibody, Prospective Studies, Aged, Granulomatosis with Polyangiitis, Reproducibility of Results, Middle Aged, United States, Female, eosinophilic granulomatosis with polyangiitis, Eosinophilic Granuloma, Europe, classification, Societies
Abstract

ObjectiveTo develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA).MethodsPatients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in five phases: (1) identification of candidate criteria items using consensus methodology, (2) prospective collection of candidate items present at the time of diagnosis, (3) data-driven reduction of the number of candidate items, (4) expert panel review of cases to define the reference diagnosis and (5) derivation of a points-based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators.ResultsThe development set for EGPA consisted of 107 cases of EGPA and 450 comparators. The validation set consisted of an additional 119 cases of EGPA and 437 comparators. From 91 candidate items, regression analysis identified 11 items for EPGA, 7 of which were retained. The final criteria and their weights were as follows: maximum eosinophil count ≥1×109/L (+5), obstructive airway disease (+3), nasal polyps (+3), cytoplasmic antineutrophil cytoplasmic antibody (ANCA) or anti-proteinase 3–ANCA positivity (−3), extravascular eosinophilic predominant inflammation (+2), mononeuritis multiplex/motor neuropathy not due to radiculopathy (+1) and haematuria (−1). After excluding mimics of vasculitis, a patient with a diagnosis of small- or medium-vessel vasculitis could be classified as having EGPA if the cumulative score was ≥6 points. When these criteria were tested in the validation data set, the sensitivity was 85% (95% CI 77% to 91%) and the specificity was 99% (95% CI 98% to 100%).ConclusionThe 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with Polyangiitis demonstrate strong performance characteristics and are validated for use in research.

Published
2022
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11. The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease

Author

Wallace, Zachary S, Naden, Ray P, Chari, Suresh, Choi, Hyon K, Della-Torre, Emanuel, Dicaire, Jean-Francois, Hart, Phillip A, Inoue, Dai, Kawano, Mitsuhiro, Khosroshahi, Arezou, Lanzillotta, Marco, Okazaki, Kazuichi, Perugino, Cory A, Sharma, Amita, Saeki, Takako, Schleinitz, Nicolas, Takahashi, Naoki, Umehara, Hisanori, Zen, Yoh, Stone, Collaborators: Akamizu T, John H., Akiyama, M, Barra, L, Bateman, A, Blockmans, D, Brito-Zeron, P, Campochiaro, C, Carruthers, M, Chiba, T, Cornell, L, Culver, E, Darabian, S, Deshpande, V, Dong, L, Ebbo, M, Fernández-Codina, A, Ferry, Ja, Fragkoulis, G, Frost, F, Frulloni, Luca, Hernandez-Molina, G, Ji, H, Keat, K, Kamisawa, T, Kawa, S, Kobayashi, H, Kodama, Y, Kubo, S, Kubota, K, Leng, H, Lerch, Mm, Liu, Y, Liu, Z, Löhr, M, Martin-Nares, E, Martinez-Valle, F, Marvisi, C, Masaki, Y, Matsui, S, Mizushima, I, Nakamura, S, Nordeide, J, Notohara, K, Paira, S, Popovic, J, Ramos-Casals, M, Rosenbaum, J, Ryu, J, Sato, Y, Sekiguchi, H, Sokol, Ev, Stone, Jr, Sun, W, Takahashi, H, Takahira, M, Tanaka, Y, Vaglio, A, Villamil, A, Wada, Y, Webster, G, Yamada, K, Yamamoto, M, Yi, J, Yi, Y, Zamboni, G, Zhang, W., Wallace, Z, Naden, Rp, Chari, S, Choi, Hk, DELLA TORRE, E, Dicaire, Jf, Hart, Pa, Inoue, D, Kawano, M, Khosroshahi, A, Lanzillotta, M, Okazaki, K, Perugino, Ca, Sharma, A, Saeki, T, Schleinitz, N, Takahashi, N, Umehara, H, Zen, Y, Stone, Jh, and Members of the ACR/EULAR IgG4-RD Classification Criteria Working, Group.

Subjects
rheumatoid arthritis, Adult, Male, 0301 basic medicine, medicine.medical_specialty, Immunology, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, parasitic diseases, Epidemiology, Humans, Immunology and Allergy, Medicine, Pathological, Sjøgren's syndrome, Aged, 030203 arthritis & rheumatology, business.industry, Middle Aged, inflammation, medicine.disease, Test (assessment), 030104 developmental biology, Rheumatoid arthritis, Radiological weapon, Female, Immunoglobulin G4-Related Disease, business, Rheumatism, Decision analysis
Abstract

IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exercises; existing literature; derivation and validation cohorts of 1879 subjects (1086 cases, 793 mimickers); and multicriterion decision analysis to identify, weight and test potential classification criteria. Two independent validation cohorts were included. A three-step classification process was developed. First, it must be demonstrated that a potential IgG4-RD case has involvement of at least one of 11 possible organs in a manner consistent with IgG4-RD. Second, exclusion criteria consisting of a total of 32 clinical, serological, radiological and pathological items must be applied; the presence of any of these criteria eliminates the patient from IgG4-RD classification. Third, eight weighted inclusion criteria domains, addressing clinical findings, serological results, radiological assessments and pathological interpretations, are applied. In the first validation cohort, a threshold of 20 points had a specificity of 99.2% (95% CI 97.2% to 99.8%) and a sensitivity of 85.5% (95% CI 81.9% to 88.5%). In the second, the specificity was 97.8% (95% CI 93.7% to 99.2%) and the sensitivity was 82.0% (95% CI 77.0% to 86.1%). The criteria were shown to have robust test characteristics over a wide range of thresholds. ACR/EULAR classification criteria for IgG4-RD have been developed and validated in a large cohort of patients. These criteria demonstrate excellent test performance and should contribute substantially to future clinical, epidemiological and basic science investigations.

Published
2019
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13. Citrullinated and homocitrullinated low- density lipoprotein in rheumatoid arthritis

Author

Rajamohan, A, Heit, B, Cairns, E, and Barra, L

Abstract

Objective: Antibodies to citrullinated and homocitrullinated (also known as carbamylated) proteins, specific for rheumatoid arthritis (RA), are associated with cardiovascular disease (CVD). Immune complexes containing these proteins have been identified in the atherosclerotic plaque of CVD patients. In mice, homocitrullinated low-density lipoprotein (HomoCitLDL) promotes foam cell formation, which is critical in the pathogenesis of atherosclerosis. We aimed to investigate the atherogenic potential of HomoCitLDL and citrullinated low-density lipoprotein (CitLDL) in RA. Method: Human LDL was homocitrullinated in potassium cyanate and citrullinated by rabbit skeletal muscle peptidyl arginine deiminase-2. The modifications were confirmed by mass spectrometry. Primary human monoctyes from healthy subjects (N = 8) were differentiated to macrophages using macrophage colony-stimulating factor and incubated with modified LDL. Foam cells were visualized using Oil Red O staining. Serum from RA patients (N = 101) and controls (N = 32) was tested for immunoglobulin G antibodies to modified LDL using enzyme-linked immunosorbent assay. Results: HomoCitLDL and CitLDL strongly induced foam cell production (> 90%) versus unmodified LDL (11%) (p Conclusions: HomoCitLDL and CitLDL have atherogenic properties in vitro. Antibody responses to HomoCitLDL, but not CitLDL, were detected in RA patients.

Published
2021
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14. Mini-review: potential of diatom-derived silica for biomedical applications

Author

Sardo, A., Orefice, I., Balzano, S., Barra, L., Romano, G., Sardo, A., Orefice, I., Balzano, S., Barra, L., and Romano, G.

Abstract

Diatoms are unicellular eukaryotic microalgae widely distributed in aquatic environments, possessing a porous silica cell wall known as frustule. Diatom frustules are considered as a sustainable source for several industrial applications because of their high biocompatibility and the easiness of surface functionalisation, which make frustules suitable for regenerative medicine and as drug carriers. Frustules are made of hydrated silica, and can be extracted and purified both from living and fossil diatoms using acid treatments or high temperatures. Biosilica frustules have proved to be suitable for biomedical applications, but, unfortunately, they are not officially recognised as safe by governmental food and medical agencies yet. In the present review, we highlight the frustule formation process, the most common purification techniques, as well as advantages and bottlenecks related to the employment of diatom-derived silica for medical purposes, suggesting possible solutions for a large-scale biosilica production.

Published
2021

15. Transnational Circulation of European TV Series. National Models and and industrial strategies for scripted pay imports/exports

Author

Barra L., Scaglioni M., Carelli, Paolo, Garofalo, Damiano, Carelli P. (ORCID:0000-0002-2552-4295), Garofalo D., Barra L., Scaglioni M., Carelli, Paolo, Garofalo, Damiano, Carelli P. (ORCID:0000-0002-2552-4295), and Garofalo D.

Abstract

In recent years, the production of TV series has grown in many European countries; in particular, pay channels and OTT players increased their offer in this genre, with several quality and premium products which became able to circulate all over the world. In this article, which is part of a wider research on production and distribution styles of TV series in Europe since 2008, we aim to retrace flows and connections among five European countries (France, Germany, Italy, Spain and United Kingdom) in order to catch the weight of exporting and exchanging context within the continent. Through a desk analysis combining quantitative and qualitative methods, the essay tries to provide a complete and detailed overview about circulation, distribution and reception of TV series in single countries, focusing on key aspects such as programming (channels and scheduling practices), aired seasons, rating audiences and previews in international audiovisual festivals.

Published
2021

16. A European Television Fiction Renaissance. Premium Production Models and Transnational Circulation

Author

Barra Luca (ORCID:0000-0001-5454-9611), Scaglioni Massimo (ORCID:0000-0002-9735-1565), Barra, L, Cailler, B, Carelli, P, Cascajosa Virino, C, Drake, P, Eichner, S, Garofalo, D, Gutiérrez Lozano, JF, Holdaway, D, Jost, F, Lombardi, G, Majer, A, Mikos, L, Monnet-Cantagrel, H, Pearson, R, Penati, C, Scaglioni, M, Sfardini, A, Szczepanik, P, Taillibert, C, Varga, B, Barra, Luca, Scaglioni, Massimo, Barra Luca (ORCID:0000-0001-5454-9611), Scaglioni Massimo (ORCID:0000-0002-9735-1565), Barra, L, Cailler, B, Carelli, P, Cascajosa Virino, C, Drake, P, Eichner, S, Garofalo, D, Gutiérrez Lozano, JF, Holdaway, D, Jost, F, Lombardi, G, Majer, A, Mikos, L, Monnet-Cantagrel, H, Pearson, R, Penati, C, Scaglioni, M, Sfardini, A, Szczepanik, P, Taillibert, C, Varga, B, Barra, Luca, and Scaglioni, Massimo

Abstract

This book maps the landscape of contemporary European premium television fiction, offering a detailed overview of both the changes in the digital production and distribution and the emergence of specific national and transnational case histories. Combining a media-production approach with a textual and audience analysis, the volume offers a complex, stratified, systemic view of ongoing aesthetic, sociocultural and industrial developments in contemporary European TV. With contributions from leading experts in the field, the book first offers an overview of the industrial, policy and cultural context for the renaissance of European television drama over the past decade, based on original comparative research. This research is then supported by case study chapters from the key contexts within which quality European television is being produced, offering a complex and complete picture of the industry’s strengths and limitations, its traditions and trends, its constraints and future perspectives.

Published
2021

17. The grounds for a renaissance in European fiction: transnational writing, production and distribution approaches, and strategies

Author

Barra, L, Scaglioni, M, Barra, Luca, Scaglioni, Massimo, Barra Luca (ORCID:0000-0001-5454-9611), Scaglioni Massimo (ORCID:0000-0002-9735-1565), Barra, L, Scaglioni, M, Barra, Luca, Scaglioni, Massimo, Barra Luca (ORCID:0000-0001-5454-9611), and Scaglioni Massimo (ORCID:0000-0002-9735-1565)

Abstract

This chapter deals with changes that have taken place in the European fiction scenario and charts the production and distribution of premium scripted television series in several European countries over the last ten years. It analyses the national histories and transnational connections among the main players behind the current growth of European premium television fiction. A discussion of some background data demonstrates the sector’s importance in the European and global television and media landscape. Building on quantitative research (e.g. industry reports, datasets, players’ shared knowledge) and qualitative findings (interviews with executives, managers and stakeholders), a series of steps is identified in the emergence of a distinct new kind of original fictional production in each country and in the European marketplace as a whole. Professional routines, industry assumptions and best practices are discussed from the different yet highly interconnected viewpoints of screenwriters, production companies and commissioners. Several shared strategies, approaches and trends provide common ground, playing a fundamental role in developing transnational titles and in circulating national productions and co-productions on a global scale.

Published
2021

18. Introduction: the many steps and factors of a European renaissance

Author

Barra, L, Scaglioni, M, Barra, Luca, Scaglioni, Massimo, Barra Luca (ORCID:0000-0001-5454-9611), Scaglioni Massimo (ORCID:0000-0002-9735-1565), Barra, L, Scaglioni, M, Barra, Luca, Scaglioni, Massimo, Barra Luca (ORCID:0000-0001-5454-9611), and Scaglioni Massimo (ORCID:0000-0002-9735-1565)

Abstract

From 2008 to 2020 television scripted-series production in Europe underwent a succession of major changes, prompting a "European television fiction renaissance". In this period an original production/distribution model for premium television fiction has developed, through trial and error, and then become established. Chapter one outlines some important developments and trends in the contemporary television and media field, tracing more than a decade of changes in fictional content production in Europe, courtesy of pay TV and the on-demand players. The research methodology is explained, spotlighting the selected countries, industry case histories and corpus of representative series. A guide to the edited collection’s various sections and chapters is also included.

Published
2021

19. Gomorra. La rinascita della produzione scripted

Author

Barra, L, Guarnaccia, F, Scaglioni, Massimo, Scaglioni, Massimo (ORCID:0000-0002-9735-1565), Barra, L, Guarnaccia, F, Scaglioni, Massimo, and Scaglioni, Massimo (ORCID:0000-0002-9735-1565)

Abstract

Il saggio si focalizza sulla serie Gomorra, giunta nel 2020 allo shooting della sua quinta stagione, uno dei migliori casi di prodotto scripted nell’ultimo decennio; strutturata su standard internazionali, ha avuto una buona distribuzione all’estero, ottenendo ampia visibilità e presenza nel dibattito critico. Vengono passati in rassegna i fattori che hanno determinato il successo e la forza innovativa di Gomorra, che incarna perfettamente il modello della “serialità premium" e che rappresenta il punto finora più alto del “modello pay” che ha caratterizzato la “renaissance” della fiction italiana contemporanea.

Published
2021

20. Towards a new model for Italian TV fiction: Sky Italia originals and the struggle for difference

Author

Barra, L, Scaglioni, M, Barra, Luca, Scaglioni, Massimo, Barra Luca (ORCID:0000-0001-5454-9611), Scaglioni Massimo (ORCID:0000-0002-9735-1565), Barra, L, Scaglioni, M, Barra, Luca, Scaglioni, Massimo, Barra Luca (ORCID:0000-0001-5454-9611), and Scaglioni Massimo (ORCID:0000-0002-9735-1565)

Abstract

The chapter focuses on original content production, distribution and promotion on pay TV in Italy and especially Sky Italia’s key role in it since 2008. Italian fiction, traditionally produced for the local internal market by the public-service broadcaster, Rai, or by the main commercial group, Silvio Berlusconi’s Mediaset, has long failed to earn worldwide acclaim. Romanzo criminale, Gomorra and other Sky Italia shows, however, are designed for global distribution and conceived as internationally co-produced, or rather co-financed, products. This overview of the pay-TV production model for scripted content addresses various aspects: the production context and culture, adopting a media production studies approach to analyse both the broadcaster’s and the production companies’ perspective; promotion, communication and scheduling; the consumption practices and textual changes marked by both continuity and discontinuity in narration and representation. The ultimate aim is to show whether (and if so, how) an Italian premium TV series model has emerged – as a distinct alternative to those traditionally developed by free-to-air broadcasters – and to explain why these series, with their local appeal and international style, are so successful in global markets.

Published
2021

22. POS0531 FACTORS ASSOCIATED WITH BASELINE HYPERTENSION IN EARLY RHEUMATOID ARTHRITIS: DATA FROM A REAL-WORLD LARGE INCIDENT COHORT

Author

Hadwen, B., primary, Stranges, S., additional, Klar, N., additional, Bindee, K., additional, Pope, J., additional, Bartlett, S. J., additional, Boire, G., additional, Bessette, L., additional, Hitchon, C., additional, Hazlewood, G., additional, Keystone, E., additional, Schieir, O., additional, Thorne, C., additional, Tin, D., additional, Valois, M. F., additional, Bykerk, V., additional, and Barra, L., additional

Published
2021
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27. Variations in the clinical practice of physicians managing Takayasu arteritis: a nationwide survey

Author

Barra L, Liang P, Benseler SM, Cabral DA, Fifi-Mah A, Li Y, Milman N, Twilt M, Yacyshyn E, and Pagnoux C

Subjects
practice guidelines, RC925-935, physician practice patterns, Diseases of the musculoskeletal system, Takayasu Arteritis
Abstract

Lillian Barra,1 Patrick Liang,2 Susanne M Benseler,3 David A Cabral,4 Aurore Fifi-Mah,5 Yueyang Li,1 Nataliya Milman,6 Marinka Twilt,3 Elaine Yacyshyn,7 Christian Pagnoux8 1Division of Rheumatology, The University of Western Ontario, St Joseph’s Health Care, London, Ontario, 2Division of Rheumatology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, 3Division of Rheumatology, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, 4Division of Rheumatology, BC Children’s Hospital, Vancouver, British Columbia, 5Division of Rheumatology, South Health Campus, University of Calgary, Calgary, Alberta, 6Division of Rheumatology, Department of Medicine, University of Ottawa, Ottawa, 7Division of Rheumatology, University of Alberta, Edmonton, Alberta, 8Department of Rheumatology, Mount Sinai Hospital, Toronto, University of Toronto, Ontario, Canada Objective: Takayasu arteritis (TAK) is a large vessel vasculitis that predominately affects young women and can cause severe ischemic complications. Given the rarity of TAK, the management of this condition is challenging. We aim to describe current rheumatologist practices for the management of TAK and identify discrepancies and gaps in knowledge. Methods: An online survey (developed by the Canadian Vasculitis Network and approved by the Canadian Rheumatology Association) containing 48 questions with regard to the diagnosis, monitoring and treatment of TAK was distributed to 495 Canadian adult and pediatric rheumatologists by email. Results: Sixty-six rheumatologists completed the survey (13% response rate): the majority (73%) were from academic centers and ≤25% reported managing more than ten patients in their career. For establishing the diagnosis of TAK, they relied on a combination of signs and symptoms of ischemia, elevations of inflammatory markers and vascular imaging (typically computed tomography and magnetic resonance angiography). The frequency of monitoring for disease activity and the methods employed (clinical, laboratory or imaging) were variable. All physicians used corticosteroids for the treatment of TAK, but 42% would treat for at least 6–12months, 26% for 12–24 months and 23% would never stop corticosteroids. Fifty-three percent would always use an immunosuppressant (most commonly methotrexate or azathioprine) in addition to corticosteroids and the remainder would only start an immunosuppressant in patients with refractory or relapsing disease. Conclusion: Physician practices for the management of TAK are variable, suggesting that there are knowledge gaps, which may impact outcomes in patients with TAK. Keywords: Takayasu arteritis, physician practice patterns, practice guidelines, large vessel vasculitis, aortitis

Published
2017

31. Cinema made in Italy. La circolazione internazionale dell'audiovisivo italiano

Author

Scaglioni Massimo (ORCID:0000-0002-9735-1565), Manzoli, G, Scaglioni, M, Fadda, M, Noto, P, Cucco, M, Garofalo, D, Morreale, E, Barra, L, Perrotta, M, Brembilla, P, Scaglioni, Massimo, Scaglioni Massimo (ORCID:0000-0002-9735-1565), Manzoli, G, Scaglioni, M, Fadda, M, Noto, P, Cucco, M, Garofalo, D, Morreale, E, Barra, L, Perrotta, M, Brembilla, P, and Scaglioni, Massimo

Abstract

Con il design e la moda, il cinema concorre in modo significativo alla creazione del “made in Italy", portando nel mondo non solo storie e ambienti, ma anche un'idea di italianità. La circolazione internazionale dei film ha contribuito a mettere a fuoco l’identità del cinema nazionale, a evidenziarne punti di forza e debolezze. Il cinema italiano ha vissuto fasi alterne per quanto riguarda la sua capacità di essere esportato: quello contemporaneo, grazie anche a una serie di trasformazioni che hanno riguardato il sistema dei media negli anni Duemila, presenta elementi positivi, tratti ancora poco studiati, perduranti criticità industriali e aperture al futuro. Questo volume è stato realizzato come esito conclusivo dell’attività del Progetto di ricerca di interesse nazionale (Bando PRIN 2015) CInCIt. Circolazione internazionale del cinema italiano, sviluppatosi tra il 2017 e il 2020, che ha visto la partecipazione di un team composto da diverse università italiane.

Published
2020

32. Renewable energy capability to save carbon emissions

Author

Coiante, D. and Barra, L.

Subjects
Alternative energy sources -- Environmental aspects, Solar energy -- Usage, Power resources -- Environmental aspects, Earth sciences, Petroleum, energy and mining industries
Abstract

The present R&D approach to new renewable energy sources includes a drawback which could negate their environmental significance. New renewable energies are affected by a technical limitation because of the random intermittent nature of their power generation which hinders them from fully expanding into the electricity market. As a consequence, the contribution which renewable electric energy sources make is just significant in terms of world electricity generation and only marginal in terms of total energy consumption. Thus, in spite of expectations, the practical achievable amount of environmental benefits arising from new renewable energy would not be enough to counteract the environmental crisis. It is known that the intermittence of energy supply can be removed by implementing grid-tied power systems, adding a further stage aimed to chemically store the intermittent solar energy by producing clean synthetic fuels. Until now this chance was considered of little importance, on the contrary, it should become a compulsory solution so that renewable energy can acquire an actual and environmentally consistent significance.

Published
1996

33. Annual energy production and room temperature effect in siting flat plate photovoltaic systems

Author

Barra, L. and Coiante, D.

Subjects
Photovoltaic cells -- Evaluation, Photovoltaic power generation -- Research, Solar energy storage -- Research, Earth sciences, Petroleum, energy and mining industries
Abstract

A method to evaluate the room temperature effect in deteriorating the performance of flat plate PV systems is investigated. The calculations, applied to crystalline Silicon arrays, show a significant energy loss with respect to reference temperature conditions, especially in correspondence to the sites with highest insolation, in which the effect can amount up to about 15%. As a consequence, the previous projections about kW h cost for large scale PV power stations should be rectified by introducing a correction factor accounting for thermal effects. The calculations were carried out for 64 zones, particularly suitable for siting PV plants and distributed among 15 countries over a latitude belt ranging from about 40 degrees North to 15 degrees South. For each zone, it was accounted both for room temperature and insolation historical data. The final results show a linear correlation between yearly global sun radiation density and room temperature effect, which appears quite general, so that, for any other site within the same latitude belt, it is possible to account for thermal effect on PV kW h cost simply by knowing the global sun radiation density on horizontal surface (usually the only experimental available datum).

Published
1993

35. Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)

Author

Antonelli, A., Palumbo, C., Noale, M., Porreca, A., Maggi, S., Simeone, C., Bassi, P., Bertoni, F., Bracarda, S., Buglione, M., Conti, G. N., Corvò, R., Gacci, M., Mirone, V., Montironi, R., Triggiani, L., Tubaro, A., Artibani, W., Crepaldi, G., Graziotti, P., Russi, E., Magrini, Stefano, Muto, M., Pecoraro, G., Ricardi, S., Zagonel, U., Alitto, Anna, Ambrosi, R., Aristei, E., Barbieri, C., Bardari, M., Bardoscia, F., Barra, L., Bartoncini, S., Basso, S., Becherini, U., Bellavita, C., Bergamaschi, R., Berlingheri, F., Berruti, S., Borghesi, M., Bortolus, R., Borzillo, V., Bosetti, D., Bove, G., Bove, P., Brausi, M., Bruni, A., Bruno, G., Brunocilla, E., Buffoli, A., Buttigliero, C., Cacciamani, G., Caldiroli, M., Cardo, G., Carmignani, G., Carrieri, G., Castelli, E., Castrezzati, E., Catalano, G., Cattarino, S., Catucci, F., Cavallini, F. D., Ceccarini, O., Celia, A., Chiancone, F., Chini, T., Cianci, C., Cisternino, A., Collura, D., Corbella, F., Corinti, M., Corsi, P., Cortese, F., Corti, L., Cosimo, De, Cristiano, N., D'Angelillo, O., Pozzo, Da, D'Agostino, L., D'Elia, D., Dandrea, C., Angelis, De, Cobelli, De, Concilio, De, Lisa, De, Luca, De, Stefani, De, Deantoni, A., C. L., Degli, Esposti, Destito, C., Detti, A., Muzio, Di, Stasio, Di, Stefano, Di, Trapani, Di, Difino, D., Falivene, G., Farullo, S., Fedelini, G., Ferrari, P., Ferraù, I., Ferro, F., Fodor, M., Fontana, A., Francesca, F., Francolini, F., Frata, G., Frezza, P., Gabriele, G., Galeandro, P., Garibaldi, M., Gennari, Pietro, Gentilucci, G., Giacobbe, A., Giussani, A., Giusti, L., Gontero, G., Guarneri, P., Guida, A., Gurioli, C., Huqi, A., Imbimbo, D., Ingrosso, C., Iotti, G., Italia, C., Mattina, La, Lamanna, P., Lastrucci, E., Lazzari, L., Liberale, G., Liguori, F., Lisi, G., Lohr, R., Lombardo, F., Lovisolo, R., J. A. J., Ludovico, Giuseppe, Macchione, M., Maggio, N., Malizia, F., Manasse, M., Mandoliti, G., Mantini, G., Marafioti, G., Marciello, L., Marconi, Alberto, Martilotta, M., Marzano, A., Masciullo, S., Maso, S., Massenzo, G., Mazzeo, A., Mearini, E., Medoro, L., Molè, S., Monesi, R., Montanari, G., Montefiore, E., Montesi, F., Morgia, G., Moro, G., Muscas, G., Musio, G., Muto, D., Muzzonigro, P., Napodano, G., Negro, G., Nidini, C. L. A., Ntreta, M., Orsatti, M., Palazzolo, M., Parisi, I., Parma, A., Pavan, P., Pericolini, N., Pinto, M., Pistone, F., Pizzuti, A., Platania, V., Polli, A., Pomara, C., Ponti, G., Porcaro, E., Porpiglia, A. B., Pugliese, F., Pycha, D., Raguso, A., Rampini, G., Randone, Donato, Roboldi, F., Roscigno, V., Ruggieri, M., Ruoppo, M. P., Sanseverino, G., Santacaterina, R., Santarsieri, A., Santoni, M., Scagliarini, R., Scagliotti, Giorgio, Scanzi, V., Scarcia, M., Schiavina, M., Sciarra, R., Sciorio, A., Scolaro, C., Scuzzarella, T., Selvaggio, S., Serao, O., Serni, A., Signor, S., Silvani, M. A., Silvano, M., Silvestris, G., Simone, F., Spagnoletti, V., Spinelli, Matteo, Squillace, G., Tombolini, L., Toninelli, V., Trinchieri, M., Trodella, A., Trodella, L. E., Trombetta, L., Tronnolone, C., Tucci, L., Urzì, M., Valdagni, D., Valeriani, R., Vanoli, M., Vitali, M., Volpe, E., Zaramella, A., Zeccolini, S., Zini, G., Antonelli, A., Palumbo, C., Noale, M., Porreca, A., Maggi, S., Simeone, C., Bassi, P., Bertoni, F., Bracarda, S., Buglione, M., Conti, G. N., Corvo, R., Gacci, M., Mirone, V., Montironi, R., Triggiani, L., Tubaro, A., Artibani, W., Crepaldi, G., Graziotti, P., Russi, E., Magrini Stefano, M., Muto, G., Pecoraro, S., Ricardi, U., Zagonel, V., Alitto Anna, R., Ambrosi, E., Aristei, C., Barbieri, M., Bardari, F., Bardoscia, L., Barra, S., Bartoncini, S., Basso, U., Becherini, C., Bellavita, R., Bergamaschi, F., Berlingheri, S., Berruti, A., Borghesi, M., Bortolus, R., Borzillo, V., Bosetti, D., Bove, G., Bove, P., Brausi, M., Bruni, A., Bruno, G., Brunocilla, E., Buffoli, A., Buttigliero, C., Cacciamani, G., Caldiroli, M., Cardo, G., Carmignani, G., Carrieri, G., Castelli, E., Castrezzati, E., Catalano, G., Cattarino, S., Catucci, F., Cavallini, F. D., Ceccarini, O., Celia, A., Chiancone, F., Chini, T., Cianci, C., Cisternino, A., Collura, D., Corbella, F., Corinti, M., Corsi, P., Cortese, F., Corti, L., de Cosimo, N., Cristiano, O., D'Angelillo, R., Da Pozzo, L., D'Agostino, D., D'Elia, C., Dandrea, M., De Angelis, M., De Angelis, P., De Cobelli, O., De Concilio, B., De Lisa, A., De Luca, S., De Stefani, A., Deantoni, C. L., Degli Esposti, C., Destito, A., Detti, B., Di Muzio, N., Di Stasio, A., Di Stefano, C., Di Trapani, D., Difino, G., Falivene, S., Farullo, G., Fedelini, P., Ferrari, I., Ferrau, F., Ferro, M., Fodor, A., Fontana, F., Francesca, F., Francolini, G., Frata, P., Frezza, G., Gabriele, P., Galeandro, M., Garibaldi, E., Gennari Pietro, G., Gentilucci, A., Giacobbe, A., Giussani, L., Giusti, G., Gontero, P., Guarneri, A., Guida, C., Gurioli, A., Huqi, D., Imbimbo, C., Ingrosso, G., Iotti, C., Italia, C., La Mattina, P., Lamanna, E., Lastrucci, L., Lazzari, G., Liberale, F., Liguori, G., Lisi, R., Lohr, F., Lombardo, R., Lovisolo, J. A. J., Ludovico Giuseppe, M., Macchione, N., Maggio, F., Malizia, M., Manasse, G., Mandoliti, G., Mantini, G., Marafioti, L., Marciello, L., Marconi Alberto, M., Martilotta, A., Marzano, S., Masciullo, S., Maso, G., Massenzo, A., Mazzeo, E., Mearini, L., Medoro, S., Mole, R., Monesi, G., Montanari, E., Montefiore, F., Montesi, G., Morgia, G., Moro, G., Muscas, G., Musio, D., Muto, P., Muzzonigro, G., Napodano, G., Negro, C. L. A., Nidini, M., Ntreta, M., Orsatti, M., Palazzolo, C., Palumbo, I., Parisi, A., Parma, P., Pavan, N., Pericolini, M., Pinto, F., Pistone, A., Pizzuti, V., Platania, A., Polli, C., Pomara, G., Ponti, E., Porcaro, A. B., Porpiglia, F., Pugliese, D., Pycha, A., Raguso, G., Rampini, A., Randone Donato, F., Roboldi, V., Roscigno, M., Ruggieri, M. P., Ruoppo, G., Sanseverino, R., Santacaterina, A., Santarsieri, M., Santoni, R., Scagliarini, S., Scagliotti Giorgio, V., Scanzi, M., Scarcia, M., Schiavina, R., Sciarra, A., Sciorio, C., Scolaro, T., Scuzzarella, S., Selvaggio, O., Serao, A., Serni, S., Signor, M. A., Silvani, M., Silvano, G., Silvestris, F., Simone, V., Spagnoletti, G., Spinelli Matteo, G., Squillace, L., Tombolini, V., Toninelli, M., Trinchieri, A., Trodella, L. E., Trodella, L., Trombetta, C., Tronnolone, L., Tucci, M., Urzi, D., Valdagni, R., Valeriani, M., Vanoli, M., Vitali, E., Volpe, A., Zaramella, S., Zeccolini, G., Zini, G., Antonelli, A, Palumbo, C, Noale, M, Porreca, A, Maggi, S, Simeone, C, Bassi, P, Bertoni, F, Bracarda, S, Buglione, M, Conti, G, Corvo, R, Gacci, M, Mirone, V, Montironi, R, Triggiani, L, Tubaro, A, Artibani, W, Crepaldi, G, Graziotti, P, Russi, E, Magrini Stefano, M, Muto, G, Pecoraro, S, Ricardi, U, Zagonel, V, Alitto Anna, R, Ambrosi, E, Aristei, C, Barbieri, M, Bardari, F, Bardoscia, L, Barra, S, Bartoncini, S, Basso, U, Becherini, C, Bellavita, R, Bergamaschi, F, Berlingheri, S, Berruti, A, Borghesi, M, Bortolus, R, Borzillo, V, Bosetti, D, Bove, G, Bove, P, Brausi, M, Bruni, A, Bruno, G, Brunocilla, E, Buffoli, A, Buttigliero, C, Cacciamani, G, Caldiroli, M, Cardo, G, Carmignani, G, Carrieri, G, Castelli, E, Castrezzati, E, Catalano, G, Cattarino, S, Catucci, F, Cavallini, F, Ceccarini, O, Celia, A, Chiancone, F, Chini, T, Cianci, C, Cisternino, A, Collura, D, Corbella, F, Corinti, M, Corsi, P, Cortese, F, Corti, L, de Cosimo, N, Cristiano, O, D'Angelillo, R, Da Pozzo, L, D'Agostino, D, D'Elia, C, Dandrea, M, De Angelis, M, De Angelis, P, De Cobelli, O, De Concilio, B, De Lisa, A, De Luca, S, De Stefani, A, Deantoni, C, Degli Esposti, C, Destito, A, Detti, B, Di Muzio, N, Di Stasio, A, Di Stefano, C, Di Trapani, D, Difino, G, Falivene, S, Farullo, G, Fedelini, P, Ferrari, I, Ferrau, F, Ferro, M, Fodor, A, Fontana, F, Francesca, F, Francolini, G, Frata, P, Frezza, G, Gabriele, P, Galeandro, M, Garibaldi, E, Gennari Pietro, G, Gentilucci, A, Giacobbe, A, Giussani, L, Giusti, G, Gontero, P, Guarneri, A, Guida, C, Gurioli, A, Huqi, D, Imbimbo, C, Ingrosso, G, Iotti, C, Italia, C, La Mattina, P, Lamanna, E, Lastrucci, L, Lazzari, G, Liberale, F, Liguori, G, Lisi, R, Lohr, F, Lombardo, R, Lovisolo, J, Ludovico Giuseppe, M, Macchione, N, Maggio, F, Malizia, M, Manasse, G, Mandoliti, G, Mantini, G, Marafioti, L, Marciello, L, Marconi Alberto, M, Martilotta, A, Marzano, S, Masciullo, S, Maso, G, Massenzo, A, Mazzeo, E, Mearini, L, Medoro, S, Mole, R, Monesi, G, Montanari, E, Montefiore, F, Montesi, G, Morgia, G, Moro, G, Muscas, G, Musio, D, Muto, P, Muzzonigro, G, Napodano, G, Negro, C, Nidini, M, Ntreta, M, Orsatti, M, Palazzolo, C, Palumbo, I, Parisi, A, Parma, P, Pavan, N, Pericolini, M, Pinto, F, Pistone, A, Pizzuti, V, Platania, A, Polli, C, Pomara, G, Ponti, E, Porcaro, A, Porpiglia, F, Pugliese, D, Pycha, A, Raguso, G, Rampini, A, Randone Donato, F, Roboldi, V, Roscigno, M, Ruggieri, M, Ruoppo, G, Sanseverino, R, Santacaterina, A, Santarsieri, M, Santoni, R, Scagliarini, S, Scagliotti Giorgio, V, Scanzi, M, Scarcia, M, Schiavina, R, Sciarra, A, Sciorio, C, Scolaro, T, Scuzzarella, S, Selvaggio, O, Serao, A, Serni, S, Signor, M, Silvani, M, Silvano, G, Silvestris, F, Simone, V, Spagnoletti, G, Spinelli Matteo, G, Squillace, L, Tombolini, V, Toninelli, M, Trinchieri, A, Trodella, L, Trombetta, C, Tronnolone, L, Tucci, M, Urzi, D, Valdagni, R, Valeriani, M, Vanoli, M, Vitali, E, Volpe, A, Zaramella, S, Zeccolini, G, and Zini, G

Subjects
Male, Patient-reported outcome measures, Prostate cancer, Quality of life, Radical prostatectomy, Sexual function, Urinary function, Patient Reported Outcome Measure, medicine.medical_treatment, 030232 urology & nephrology, Longitudinal Studie, Aged, Data Collection, Humans, Italy, Longitudinal Studies, Middle Aged, Patient Reported Outcome Measures, Prospective Studies, Prostate, Prostatectomy, Prostatic Neoplasms, Quality of Life, Retrospective Studies, Robotic Surgical Procedures, Surveys and Questionnaires, Treatment Outcome, Propensity Score, 0302 clinical medicine, Retrospective Studie, Medicine, Surveys and Questionnaire, Prospective cohort study, Patient-reported outcome measure, 030220 oncology & carcinogenesis, Human, medicine.medical_specialty, Robotic Surgical Procedure, Urology, 03 medical and health sciences, Clinical significance, business.industry, Retrospective cohort study, Prospective Studie, Propensity score matching, Prostatic Neoplasm, Observational study, business
Abstract

Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP). ­Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head ­comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment * time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.

Published
2019

36. The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease

Author

Wallace, Zachary S, Naden, Ray P, Chari, Suresh, Choi, Hyon, Della-Torre, Emanuel, Dicaire, Jean-Francois, Hart, Phil A, Inoue, Dai, Kawano, Mitsuhiro, Khosroshahi, Arezou, Kubota, Kensuke, Lanzillotta, Marco, Okazaki, Kazuichi, Perugino, Cory A, Sharma, Amita, Saeki, Takako, Sekiguchi, Hiroshi, Schleinitz, Nicolas, Stone, James R, Takahashi, Naoki, Umehara, Hisanori, Webster, George, Zen, Yoh, Stone, John H, Akamizu, T, Akiyama, M, Barra, L, Bateman, A, Blockmans, D, Brito-Zeron, P, Campochiaro, C, Carruthers, M, Chari, S, Chiba, T, Choi, H, Cornell, L, Culver, E, Darabian, S, Torre, Ed, Deshpande, V, Dong, L, Ebbo, M, Fernández-Codina, A, Ferry, Ja, Fragkoulis, G, Frost, F, Frulloni, L, Hart, Pa, Hernandez-Molina, G, Inoue, D, Ji, H, Keat, K, Kamisawa, T, Kawa, S, Kawano, M, Khosroshahi, A, Kobayashi, H, Kodama, Y, Kubo, S, Kubota, K, Lanzillotta, M, Leng, H, Lerch, M, Liu, Y, Liu, Z, Löhr, M, Martin-Nares, E, Martinez-Valle, F, Marvisi, C, Masaki, Y, Matsui, S, Mizushima, I, Naden, Rp, Nakamura, S, Nordeide, J, Notohara, K, Okazaki, K, Paira, S, Perugino, Ca, Popovic, J, Ramos-Casals, M, Rosenbaum, J, Ryu, J, Saeki, T, Sato, Y, Schleinitz, N, Sekiguchi, H, Sharma, A, Sokol, Ev, Stone, Jr, Stone, Jh, Sun, W, Takahashi, H, Takahashi, N, Takahira, M, Tanaka, Y, Umehara, H, Vaglio, A, Villamil, A, Wada, Y, Wallace, Zs, Webster, G, Yamada, K, Yamamoto, M, Yi, J, Yi, Y, Zamboni, G, Zen, Y, Zhang, W., Wallace, Z, Naden, Rp, Chari, S, Choi, H, DELLA TORRE, E, Dicaire, Jf, Hart, Pa, Inoue, D, Kawano, M, Khosroshahi, A, Kubota, K, Lanzillotta, M, Okazaki, K, Perugino, Ca, Sharma, A, Saeki, T, Sekiguchi, H, Schleinitz, N, Stone, Jr, Takahashi, N, Umehara, H, Webster, G, Zen, Y, Stone, Jh, and American College of Rheumatology/European League Against Rheumatism IgG4-Related Disease Classification Criteria Working, Group.

Subjects
Adult, Male, medicine.medical_specialty, Consensus, Aged, Diagnosis, Differential, Europe, Female, Humans, Immunoglobulin G4-Related Disease, Middle Aged, Reproducibility of Results, Rheumatology, Societies, Medical, United States, Immunology, MEDLINE, Disease, Internal medicine, Medical, parasitic diseases, Diagnosis, Immunology and Allergy, Medicine, business.industry, medicine.disease, Confidence interval, Test (assessment), Differential, IgG4-related disease, business, Societies, Rheumatism, Decision analysis
Abstract

Objective IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. Methods An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exercises, existing literature, derivation and validation cohorts of 1,879 subjects (1,086 cases, 793 mimickers), and multicriterion decision analysis to identify, weight, and test potential classification criteria. Two independent validation cohorts were included. Results A 3-step classification process was developed. First, it must be demonstrated that a potential IgG4-RD case has involvement of at least 1 of 11 possible organs in a manner consistent with IgG4-RD. Second, exclusion criteria consisting of a total of 32 clinical, serologic, radiologic, and pathologic items must be applied; the presence of any of these criteria eliminates the patient from IgG4-RD classification. Third, 8 weighted inclusion criteria domains, addressing clinical findings, serologic results, radiology assessments, and pathology interpretations, are applied. In the first validation cohort, a threshold of 20 points had a specificity of 99.2% (95% confidence interval [95% CI] 97.2-99.8%) and a sensitivity of 85.5% (95% CI 81.9-88.5%). In the second, the specificity was 97.8% (95% CI 93.7-99.2%) and the sensitivity was 82.0% (95% CI 77.0-86.1%). The criteria were shown to have robust test characteristics over a wide range of thresholds. Conclusion ACR/EULAR classification criteria for IgG4-RD have been developed and validated in a large cohort of patients. These criteria demonstrate excellent test performance and should contribute substantially to future clinical, epidemiologic, and basic science investigations.

Published
2018

38. Appassionati Dissodatori. Storia e storiografia della televisione in Italia. Studi in onore di Aldo Grasso

Author

Massimo Scaglioni (ORCID:0000-0002-9735-1565), Scaglioni, M, Ornaghi, L, Penati, C, Garofalo, D, Bourdon, J, Freccero, C, Ortoleva, P, Richeri, G, Sangiovanni, A, Balbi, G, Ellis, J, Barra, L, Giaccardi, C, Sfardini, A, Piazzoni, I, Valentini, P, Gozzini, G, Menduni, E, Mancuso, M, Carini, S, Carelli, P, Zanola, MT, Missaglia, F, Petrosino, S, Gobber, G, Scaglioni, Massimo, Massimo Scaglioni (ORCID:0000-0002-9735-1565), Scaglioni, M, Ornaghi, L, Penati, C, Garofalo, D, Bourdon, J, Freccero, C, Ortoleva, P, Richeri, G, Sangiovanni, A, Balbi, G, Ellis, J, Barra, L, Giaccardi, C, Sfardini, A, Piazzoni, I, Valentini, P, Gozzini, G, Menduni, E, Mancuso, M, Carini, S, Carelli, P, Zanola, MT, Missaglia, F, Petrosino, S, Gobber, G, and Scaglioni, Massimo

Abstract

Questo volume nasce come un omaggio al lavoro di Aldo Grasso che, dagli anni Settanta, attraverso l’attività di ricerca e di didattica presso l’Università Cattolica del Sacro Cuore di Milano, ma anche – dagli anni Novanta – con il quotidiano ‘corpo a corpo’ coi programmi – «i testi» – della televisione italiana, e i suoi protagonisti, ha insegnato ai suoi allievi, e al più vasto pubblico raggiunto dalle pagine del «Corriere della Sera», un approccio critico e contemporaneamente appassionato al medium saldamente centrale nella cultura italiana della seconda metà del Novecento e, ancora, del nuovo secolo. Il volume si focalizza su alcune questioni rilevanti: in che modo è possibile riflettere criticamente e fare ricerca sul ruolo di un mezzo tanto immediato e popolare quanto complesso nelle sue articolazioni e rilevante dal punto di vista culturale e sociale? Quali prospettive può adottare lo studio storiografico della televisione, e a quali fonti deve ricorrere?

Published
2019

39. The effect of rheumatoid arthritis-associated autoantibodies on the incidence of cardiovascular events in a large inception cohort of early inflammatory arthritis

Author

Barra, Lillian J., Pope, Janet E., Hitchon, Carol, Boire, Gilles, Schieir, Orit, Lin, Daming, Thorne, Carter J., Tin, Diane, Keystone, Edward C., Haraoui, Boulos, Jamal, Shahin, Bykerk, Vivian P., Ahluwalia, V., Akhavan, P., Barra, L., Barber, C., Barnabe, C., Bartlett, S., Baron, M., Bessette, L., Boire, G., Bykerk, V., Colmegna, I., Fallavollita, S., and Haaland, D.

Subjects
Male, 0301 basic medicine, Canada, medicine.medical_specialty, Complications, Inflammatory arthritis, Arthritis, Kaplan-Meier Estimate, Peptides, Cyclic, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Rheumatoid Factor, Risk Factors, Internal medicine, medicine, Medicine and Health Sciences, Humans, Rheumatoid factor, Pharmacology (medical), Prospective Studies, Risk factor, Rheumatoid arthritis, Prospective cohort study, Autoantibodies, 030203 arthritis & rheumatology, Analysis of Variance, Proportional hazards model, business.industry, Incidence, Seropositive, Early Inflammatory Arthritis, Middle Aged, medicine.disease, ACPA, Cardiovascular disease, 030104 developmental biology, Cardiovascular Diseases, Antirheumatic Agents, Hypertension, Cohort, RF, Female, business
Abstract

© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Objective. RA is associated with an increased risk of cardiovascular events (CVEs). The objective was to estimate independent effects of RA autoantibodies on the incident CVEs in patients with early RA. Methods. Patients were enrolled in the Canadian Early Inflammatory Arthritis Cohort, a prospective multicentre inception cohort. Incident CVEs, including acute coronary syndromes and cerebrovascular events, were self-reported by the patient and partially validated by medical chart review. Seropositive status was defined as either RF or ACPA positive. Multivariable Cox proportional hazards survival analysis was used to estimate the effects of seropositive status on incident CVEs, controlling for RA clinical variables and traditional cardiovascular risk factors. Results. A total of 2626 patients were included: the mean symptom duration at diagnosis was 6.3 months (S.D. 4.6), the mean age was 53 years (S.D. 15), 72% were female and 86% met classification criteria for RA. Forty-six incident CVEs occurred over 6483 person-years [incidence rate 7.1/1000 person-years (95% confidence interval 5.3, 9.4)]. The CVE rate did not differ in seropositive vs seronegative subjects and seropositivity was not associated with incident CVEs in multivariable Cox regression models. Baseline covariates independently associated with incident CVEs were older age, a history of hypertension and a longer duration of RA symptoms prior to diagnosis. Conclusion. The rate of CVEs early in the course of inflammatory arthritis was low; however, delays in the diagnosis of arthritis increased the rate of CVEs. Hypertension was the strongest independent risk factor for CVEs. Results support early aggressive management of RA disease activity and co-morbidities to prevent severe complications.

Published
2017

40. Standardization of laparoscopic left hemicolectomy: a single-center experience of 484 cases

Author

Corcione F, Umberto Bracale, Barra L, Pirozzi F, Cuccurullo D, Andreoli F, Corcione, F, Bracale, Umberto, Barra, L, Pirozzi, F, Cuccurullo, D, and Andreoli, F.

Subjects
Adult, Aged, 80 and over, Male, Colonic Polyps, Length of Stay, Middle Aged, Patient Readmission, Perioperative Care, Postoperative Complications, Colonic Neoplasms, Diverticulosis, Colonic, Humans, Lymph Node Excision, Female, Laparoscopy, Intraoperative Complications, Colectomy, Aged, Retrospective Studies
Abstract

Aim: Laparoscopic surgery has become recognized as an established technique for colon diseases and many different surgical techniques have been described. The aim of our study is to show the results of a single institution where a standardized operative and perioperative procedure for laparoscopic left hemicolectomy (LLH) has been used. Methods: Between January 2005 and April 2011, 484 patients underwent LLH for colon diseases. Data collected included age, indication for surgery, ASA class, body mass index, operating time, intra and post-operative complications, conversion rate, length of hospital stay, tumor stage, number of lymph nodes harvested, mortality, and a 30-day readmission rate. Results: We found 299 cancer, 29 large dysplastic polyps and 156 complicated diverticular diseases. Average operation time was 120 minutes. The average hospital stay was 5.7 days. In the cancer group, the average number of lymph nodes harvested was 12.7. The intraoperative and early postoperative complications were 3.3% and 10.7 % respectively. The conversion rate was 3.7%. The 30-day readmission rate was 3%. The 30-day mortality rate was 0.4%. Conclusion: The standardization of the LLH technique might reduce the technical difficulties and complications. Its potential benefits include the standardization of surgical instrument sets, the definition of benchmarks for conversion before making any inappropriate investment in time and equipment, low rates of complications and readmission rate.

Published
2013

41. Prevalence and Characteristics of Metabolic Syndrome Differ in Men and Women with Early Rheumatoid Arthritis.

Author

Kuriya, B., Schieir, O., Valois, M. F., Pope, J. E., Boire, G., Bessette, L., Hazlewood, G., Thorne, J. C., Tin, D., Hitchon, C., Bartlett, S., Keystone, E. C., Bykerk, V. P., and Barra, L.

Abstract

Objective: Metabolic syndrome (MetS) prevalence in early rheumatoid arthritis (ERA) is conflicting. The impact of sex, including menopause, has not been described. We estimated the prevalence and factors associated with MetS in men and women with ERA. Methods: A cross‐sectional study of the Canadian Early Arthritis Cohort (CATCH) was performed. Participants with baseline data to estimate key MetS components were included. Sex‐stratified logistic regression identified baseline variables associated with MetS. Results: The sample included 1543 participants; 71% were female and the mean age was 54 (SD 15) years. MetS prevalence was higher in men 188 (42%) than women 288 (26%, P < 0.0001) and increased with age. Frequent MetS components in men were hypertension (62%), impaired glucose tolerance (IGT, 40%), obesity (36%), and low high‐density lipoprotein cholesterol (36%). Postmenopausal women had greater frequency of hypertension (65%), IGT (32%), and high triglycerides (21%) compared with premenopausal women (P < 0.001). In multivariate analysis, MetS was negatively associated with seropositivity and pulmonary disease in men. Increasing age was associated with MetS in women. In postmenopausal women, corticosteroid use was associated with MetS. Psychiatric comorbidity was associated with MetS in premenopausal women. MetS status was not explained by disease activity or core RA measures. Conclusion: The characteristics and associations of MetS differed in men and women with ERA. Sex differences, including postmenopausal status, should be considered in comorbidity screening. With this knowledge, the interplay of MetS, sex, and RA therapeutic response on cardiovascular outcomes should be investigated. [ABSTRACT FROM AUTHOR]

Published
2019
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42. 'Gente di mare'. Il Tirreno Meridionale come frontiera

Author

Albanese, V, Amato, F, Barilaro, C, Barra, L, Corinto, GL, Cucco, M, Graziano, T, Irimiàs, A, Muti, G, Nencioni, G, Nicosia, E, Pollice, F, Porto, CM, Squarcina, E, Albanese, V, Amato, F, Barilaro, C, Barra, L, Corinto, GL, Cucco, M, Graziano, T, Irimiàs, A, Muti, G, Nencioni, G, Nicosia, E, Pollice, F, Porto, CM, and Squarcina, E

Abstract

Con il titolo "Gente di mare" la RAI ha prodotto una fiction che ha come protagonisti gli uomini e le donne appartenenti al Corpo della Guardia Costiera. Dalla narrazione emerge una visione della costa del Tirreno Meridionale come di una fascia di transizione tra la terra ferma, dove i ruoli, sia positivi che negativi, sono chiari e il mare aperto, uno spazio dove si svolge la lotta tra apparati dello Stato e organizzazioni criminali per il suo controllo. La Capitaneria di porto di Tropea viene così descritta come un baluardo di legalità volto a fronteggiare una frontiera al tempo stesso insediativa e militare

Published
2017

43. La televisione. Modelli teorici e percorsi d’analisi

Author

Massimo Scaglioni (ORCID:0000-0002-9735-1565), Anna Sfardini (ORCID:0000-0001-9026-6758), Scaglioni, M, Cucco, M, Barra, L, Penati, C, Sfardini, A, Fiacco, A, Gorla, C, Duranti, MC, Costalonga, B, Squadrone, C, Turrini, J, Nozzoli, V, Sampietro, S, Carelli, P, Suma, G, Brembilla, P, Temporelli, M, Scaglioni, Massimo, Sfardini, Anna, Massimo Scaglioni (ORCID:0000-0002-9735-1565), Anna Sfardini (ORCID:0000-0001-9026-6758), Scaglioni, M, Cucco, M, Barra, L, Penati, C, Sfardini, A, Fiacco, A, Gorla, C, Duranti, MC, Costalonga, B, Squadrone, C, Turrini, J, Nozzoli, V, Sampietro, S, Carelli, P, Suma, G, Brembilla, P, Temporelli, M, Scaglioni, Massimo, and Sfardini, Anna

Abstract

Gli esplosivi anni Duemila, con la tecnologia digitale e la forza della “convergenza mediale”, sono caratterizzati da spinte contrastanti che hanno portato verso una tv sempre più “multipla”, non soltanto in termini di abbondanza di offerta, di reti, di contenuti, ma anche in relazione al sovrapporsi di modelli di business, di percorsi di fruizione, di tipologie di prodotti e generi. Per comprendere, dunque, che cos’è la televisione oggi occorre affinare gli strumenti di analisi, accettare la sfida della complessità del mezzo, muoversi lungo i confini delle competenze e delle discipline. Questo libro rappresenta il risultato, in piena modalità Telvision Studies, di un dialogo aperto tra due mondi: quello dello sguardo degli studiosi di televisione, portatori di un approccio teorico e metodologico di studio e ricerca sul mezzo e quello della competenza dei professionisti impegnati nel settore dell’industria televisiva. Il volume si propone, infatti, un obiettivo preciso: offrire a coloro che hanno intrapreso un percorso di studi nel settore dei media e della tv, o che aspirano a sviluppare il loro profilo professionale in questo campo, una visione sui principali approcci di analisi a questo mezzo e sulle routine che ne regolano il funzionamento. Il volume è suddiviso in due sezioni. La Parte prima, "Studiare la televisione: approcci e metodi", offre una disamina delle diverse prospettive di studio con cui la televisione è stata analizzata nel corso della sua storia, fornendo gli strumenti (e il vocabolario) di fondo per inquadrare analiticamente il mezzo. La Parte seconda, "Analizzare la televisione: case studies", trasferisce sulla carta il lavoro quotidiano che si compie nelle imprese televisive, nella sua concretezza di strategie operative, pratiche professionali e terminologie specifiche che sostanziano l’approccio industry alla tv. Alla fine di tale percorso, il lettore avrà a disposizione tutti gli strumenti utili per comprendere che cos’è, come si è t

Published
2017

45. Histone hyperracetylation affects meiotic recombination and chromosome segregation in Arabidopsis

Author

PERRELLA, GIORGIO, CONSIGLIO, MARIA FEDERICA, ERRICO, ANGELA, Aiese Cigliano R., Cremona G., Sanchez Moran E., Barra L., Bressan R. A., Christopher F., Franklin H., Conicella C., Perrella, Giorgio, Consiglio, MARIA FEDERICA, Aiese Cigliano, R., Cremona, G., Sanchez Moran, E., Barra, L., Errico, Angela, Bressan, R. A., Christopher, F., Franklin, H., and Conicella, C.

Abstract

SUMMARY In this study, the meiotic role of MEIOTIC CONTROL OF CROSSOVERS1 (MCC1), a GCN5-related histone N-acetyltransferase, is described in Arabidopsis. Analysis of the over-expression mutant obtained by enhancer activation tagging revealed that acetylation of histone H3 increased in male prophase I. MCC1 appeared to be required in meiosis for normal chiasma number and distribution and for chromosome segregation. Overall, elevated MCC1 did not affect crossover number per cell, but has a differential effect on individual chromosomes elevating COs for chromosome 4, in which there is also a shift in chiasma distribution, and reducing COs for chromosome 1 and 2. For the latter there is a loss of the obligate CO/chiasma in 8% of the male meiocytes. The meiotic defects led to abortion in about half of the male and female gametes in the mutant. In wild type, the treatment with trichostatin A, an inhibitor of histone deacetylases, phenocopies MCC1 over-expression in meiosis. Our results provide evidence that histone hyperacetylation has a significant impact on the plant meiosis.

Published
2010

46. [Laparoscopic total fundoplication is not an obstacle to oesophageal emptying after oesophago-gastric myotomy for the surgical treatment of achalasia]

Author

Pizza F, Rossetti G, Del Genio G, Maffettone V, Napolitano V, Allaria A, Brusciano L, Montesarchio L, Salvatore Tolone, Di Martino M, Fs, Lucido, Barra L, Giugliano S, D'Alessandro A, Del Genio F, Nl, Pizza, Del Genio A, Pizza, F, Rossetti, G, Del Genio, G, Maffettone, V, Napolitano, V, Allaria, A, Brusciano, L, Montesarchio, L, Tolone, S, Di Martino, M, Lucido, F. S., Barra, L, Giugliano, S, D'Alessandro, A, Del Genio, F, Pizza, N. L., and Del Genio, A

Subjects
Adult, Male, Time Factors, Adolescent, Manometry, Fundoplication, Length of Stay, Middle Aged, Esophageal Achalasia, Treatment Outcome, Gastroesophageal Reflux, Humans, Female, Laparoscopy, Child, Deglutition Disorders, Aged, Follow-Up Studies
Abstract

There are different surgical possibilities for the treatment of oesophageal achalasia ranging from a short extramucosal oesophagomyotomy to an extended esophago-gastric myotomy combined with a partial fundoplication to restore the main antireflux barrier. A total 360 degrees fundoplication is generally regarded as an obstacle to oesophageal emptying. The aim of this study was to evaluate the role and efficacy of total 360 degrees laparoscopic Nissen-Rossetti fundoplication after oesophago gastric myotomy in the treatment of oesophageal achalasia. From 1992 to January 2008, a total of 245 patients (112 males, 133 females), mean age 45.1 years (range: 12-79), were submitted to laparoscopic Nissen-Rossetti fundoplication after a Heller myotomy with endoscopic and manometric intraoperative monitoring. In 3 patients (1.2%), conversion to laparotomy was necessary. Mean operative time was 60 +/- 15 minutes. No mortality was observed. The overall morbidity rate was 1.6%. The mean postoperative hospital stay was 3.5 +/- 1.0 days (range: 1-12 days). A mean clinical follow-up of 100.2 +/- 7 months (range: 3-177) was possible for 228 patients (93.1%), and an excellent or good outcome was observed in 209 patients (91.7%) (DeMeester dysphagia score 0-1). No improvement in dysphagia was observed in 5 (2.2%) patients. Pathological gastro-oesophageal reflux was absent in all patients. Laparoscopic Nissen-Rossetti fundoplication after a Heller myotomy is a safe, effective treatment for oesophageal achalasia with excellent results in terms of dysphagia resolution, affording total protection from the onset of gastrooesophageal reflux.

Published
2009

47. Efecto de diferentes niveles de riego en el rendimiento de rosa mosqueta (Rosa canina L.), en la zona Centro-Sur de Chile

Author

Quezada, C., Sandoval, M., Serri, H., Barra, L., Rillon, S., and Barriga, R.

Abstract

The water resource is the limiting factor in rainfed areas for the introduction of new production alternatives. The objective of this field experiment was to evaluate the effect of different water levels on yield components of rose hip orchards (Rosa caninaL.) located in South-Central Chile, during the 2011-2012 growing season, in an Aquic Palexeralfs soil under drip irrigation. The field experimental design was completely randomized with four water treatments set as a function of applied irrigation depth (ID) in the farm (ID) : 0,25 ID; 0,5 ID; 1 ID (control) and 2 ID with three replicates of five plants. Applied water volume, soil water content, stomatal conductance, yield components, industrial yield and water productivity were determined. Results showed that the water requirements of rose hip were lower and equivalent to supplementary irrigation during the period of maximum evapotranspiration. The different water levels did not affect the physiological parameters and yield components. Application of the 50% irrigation depth achieved a good dry pulp yield and it is an adequate irrigation strategy for rainfed areas with water scarcity. &nbsp, El recurso hídrico es el factor limitante en zonas de secano para introducir nuevas alternativas productivas. El objetivo de esta investigación fue evaluar el efecto de diferentes niveles de riego en el rendimiento de Rosa Mosqueta (Rosa caninaL.) en un suelo Aquic Palexeralfs bajo riego por goteo en la zona centro-sur de Chile. El diseño experimental fue completamente al azar con cuatro tratamientos hídricos en función de la lámina de riego aplicada en el predio (LR): 0,25 LR; 0,5 LR; 1 LR y 2 LR, con tres repeticiones de 5 plantas. Se evaluó volumen de agua aplicada, contenido de agua en el suelo, conductancia estomática, componentes de rendimiento, rendimiento industrial y productividad del agua. Los resultados obtenidos muestran que los requerimientos hídricos de Rosa Mosqueta fueron bajos y equivalentes a un riego suplementario en el período de mayor evapotranspiración. Los diferentes niveles de aplicación de agua no afectaron significativamente los parámetros fisiológicos ni los componentes de rendimiento. La aplicación del 50% de la lámina de riego presentó un buen rendimiento de pulpa seca y es una estrategia de riego adecuada para zonas de secano con escasez del recurso hídrico. &nbsp

Published
2014

48. THE PROXIMAL MIGRATION OF RFLUX IS RESPONSIBLE OF RESPIRATORY SYMPTOMS IN PATIENTS WITH GASTRO:ESOPHAGEAL REFLUX DISEASE: ASSESSMENT WITH MULTICHANNEL INTRALUMINAL IMPEDANCE (MII)

Author

Del Genio g., Rossetti G., Brusciano L., Pizza f., TOLONE, SALVATORE, Russo F., Di Martino M., Picarella P., Lucido F., Barra L., Giugliano S., D’Alessandro A., Montesarchio L., Napolitano V., ALLARIA, Alfredo, Del Genio A., MAFFETTONE, Vincenzo, Del Genio, G., Rossetti, G., Brusciano, L., Pizza, F., Tolone, Salvatore, Russo, F., Di Martino, M., Picarella, P., Lucido, F., Barra, L., Giugliano, S., D’Alessandro, A., Montesarchio, L., Maffettone, Vincenzo, Napolitano, V., Allaria, Alfredo, and Del Genio, A.

Published
2008

49. ELECTRICAL STIMULATION AS A CONSERVATIVE TREATMENT FOR PATHOLOGIC DUODENO_GASTRIC REFLUX (DGR) ASSOCIATED TO DELAYED GASTRI EMPTYING: INITIAL EXPERIENCE

Author

Del Genio G., Rossetti G., Brusciano L., Pizza F., TOLONE, SALVATORE, Russo F., Di Martino M., Picarella P., Lucido F., Barra L., Giugliano S., D’Alessandro A., Montesarchio L., Napolitano V., ALLARIA, Alfredo, Del Genio A., MAFFETTONE, Vincenzo, Del Genio, G., Rossetti, G., Brusciano, L., Pizza, F., Tolone, Salvatore, Russo, F., Di Martino, M., Picarella, P., Lucido, F., Barra, L., Giugliano, S., D’Alessandro, A., Montesarchio, L., Maffettone, Vincenzo, Napolitano, V., Allaria, Alfredo, and Del Genio, A.

Published
2008

50. CAN COMBINED MII-pH BECOME A USEFUL GOAL FOR SURGEON IN SELECTING PATIENTS FOR LAPAROSCOPIC FUNDOPLICATION?

Author

Del Genio G., Rossetti G., Brusciano L., Pizza F., TOLONE, SALVATORE, Russo F., Di Martino M., Picarella P., Lucido F., Barra L., Giugliano S., D’Alessandro A., Montesarchio L., Napolitano V., ALLARIA, Alfredo, Del Genio A., MAFFETTONE, Vincenzo, Del Genio, G., Rossetti, G., Brusciano, L., Pizza, F., Tolone, Salvatore, Russo, F., Di Martino, M., Picarella, P., Lucido, F., Barra, L., Giugliano, S., D’Alessandro, A., Montesarchio, L., Maffettone, Vincenzo, Napolitano, V., Allaria, Alfredo, and Del Genio, A.

Published
2008

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