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1,020 results on '"Barr, Dana B."'

6. Home-based community health worker intervention to reduce pesticide exposures to farmworkers’ children: A randomized-controlled trial

Author

Salvatore, Alicia L, Castorina, Rosemary, Camacho, José, Morga, Norma, López, Jesús, Nishioka, Marcia, Barr, Dana B, Eskenazi, Brenda, and Bradman, Asa

Subjects
Public Health, Health Sciences, Rural Health, Behavioral and Social Science, Health Disparities, Prevention, Clinical Trials and Supportive Activities, Clinical Research, Pediatric, Health Services, Social Determinants of Health, Endocrine Disruptors, Adult, Agriculture, California, Child, Preschool, Community Health Workers, Environmental Exposure, Family Characteristics, Female, Humans, Insecticides, Male, Organophosphate Poisoning, Organophosphates, Pesticides, children, community-based participatory research, exposure, farmworker, intervention, pesticides, Chemical Sciences, Environmental Sciences, Medical and Health Sciences, Epidemiology, Public health
Abstract

We conducted a randomized-controlled trial of a home-based intervention to reduce pesticide exposures to farmworkers' children in Monterey County, California (n=116 families). The intervention consisted of three home-based educational sessions delivered by community health workers in Spanish. Measurements of organophosphate (OP) insecticide metabolites in child urine (n=106) and pesticides in home floor wipes (n=103) were collected before and after the intervention. Median child urinary dialkyl phosphate (DAP) metabolite levels were slightly lower among the intervention group children at follow-up compared with baseline, albeit nonsignificantly. DAP metabolite levels in the control group children were markedly higher at follow-up compared with baseline. In adjusted models, intervention participation was associated with a 51% decrease in total DAP metabolite levels. Carbaryl, chlorpyrifos, cypermethrin, dacthal, diazinon, malathion, and trans-permethrin were commonly detected in the floor wipes. In adjusted models, intervention participation was significantly associated with a 37% decrease in trans-permethrin floor wipe levels in homes, but not OP or other agricultural pesticides. In summary, intervention group children had slightly reduced pesticide exposures, whereas child exposures were higher among the control group. Additional intervention studies evaluating methods to reduce pesticide exposures to farmworker families and children are needed.

Published
2015

26. Exposure Assessment in the National Children's Study: Introduction

Author

Needham, Larry L., Özkaynak, Halûk, Whyatt, Robin M., Barr, Dana B., Wang, Richard Y., Naeher, Luke, Akland, Gerry, Bahadori, Tina, Bradman, Asa, Fortmann, Roy, Morandi, Maria, O'Rourke, Mary Kay, Thomas, Kent, Quackenboss, James, Ryan, P. Barry, and Zartarian, Valerie

Published
2005

29. Serum Persistent Organic Pollutants and Duration of Lactation among Mexican‐American Women

Author

Weldon, Rosana H, Webster, Monique, Harley, Kim G, Bradman, Asa, Fenster, Laura, Davis, Mark D, Hubbard, Alan, Barr, Dana B, Holland, Nina, and Eskenazi, Brenda

Subjects
Public Health, Health Sciences, Nutrition, Endocrine Disruptors, Breastfeeding, Lactation and Breast Milk, Pediatric, Adolescent, Adult, California, Estrogens, Female, Humans, Hydrocarbons, Chlorinated, Kaplan-Meier Estimate, Lactation, Longitudinal Studies, Mexican Americans, Middle Aged, Pesticides, Polychlorinated Biphenyls, Pregnancy, Principal Component Analysis, Proportional Hazards Models, Self Report, Time Factors, Young Adult, Environmental Science and Management, Public Health and Health Services, Public health
Abstract

BackgroundResearch suggests that estrogenic endocrine-disrupting chemicals interfere with lactation.Objectives(1) to determine if estrogenic persistent organic pollutants (POPs) are associated with shortened lactation duration; (2) to determine whether previous breastfeeding history biases associations.Methods and resultsWe measured selected organochlorines and polychlorinated biphenyls (p, p'-DDE, p, p'-DDT, o, p'-DDT, beta-hexachlorocyclohexane, hexachlorobenzene, and PCBs 44, 49, 52, 118, 138, 153, and 180) in serum from 366 low-income, Mexican-American pregnant women living in an agricultural region of California and assessed breastfeeding duration by questionnaires. We found no association between DDE, DDT, or estrogenic POPs with shortened lactation duration, but rather associations for two potentially estrogenic POPs with lengthened lactation duration arose (HR [95% CI]: 0.6 [0.4, 0.8] for p, p'-DDE & 0.8 [0.6, 1.0] for PCB 52). Associations between antiestrogenic POPs (PCBs 138 and 180) and shortened lactation duration were attributed to a lactation history bias.ConclusionEstrogenic POPs were not associated with shortened lactation duration, but may be associated with longer lactation duration.

Published
2010

43. Phthalate Exposure and Human Semen Parameters

Author

Duty, Susan M., Silva, Manori J., Barr, Dana B., Brock, John W., Ryan, Louise, Chen, Zuying, Herrick, Robert F., Christiani, David C., and Hauser, Russ

Published
2003

45. Diet and nondiet predictors of urinary 3-phenoxybenzoic acid in NHANES 1999-2002.

Author

Riederer, Anne M, Bartell, Scott M, Barr, Dana B, and Ryan, P Barry

Subjects
Adolescent, Adult, Age Factors, Benzoates: urine, Child, Diet, Diet Surveys, Environmental Monitoring, Humans, Pesticides: urine, Regression Analysis, Sample Size, Smoking, 3-Phenoxybenzoic acid, Biomarkers, Dietary exposure, Pesticides, Pyrethroids3 phenoxybenzoic acid, benzoic acid derivative, cytochrome P450, pesticide, pyrethroid, unclassified drug, 3 phenoxybenzoic acid, 3-phenoxybenzoic acid, benzoic acid derivative, pesticide, accuracy, adolescent, article, child, cigarette smoking, controlled study, diet restriction, environmental exposure, enzyme inhibition, food contamination, food intake, gardening, health survey, human, information processing, major clinical study, mathematical analysis, prediction, priority journal, regression analysis, United States, urinalysis, adult, age, diet, environmental monitoring, sample size, smoking, urine, Nicotiana tabacum, Adolescent, Adult, Age Factors, Benzoates, Child, Diet, Diet Surveys, Environmental Monitoring, Humans, Pesticides, Regression Analysis, Sample Size, Smoking, Adolescent, Adult, Age Factors, Benzoates: urine, Child, Diet, Diet Surveys, Environmental Monitoring, Humans, Pesticides: urine, Regression Analysis, Sample Size, Smoking, 3-Phenoxybenzoic acid, Biomarkers, Dietary exposure, Pesticides, Pyrethroids3 phenoxybenzoic acid, benzoic acid derivative, cytochrome P450, pesticide, pyrethroid, unclassified drug, 3 phenoxybenzoic acid, 3-phenoxybenzoic acid, benzoic acid derivative, pesticide, accuracy, adolescent, article, child, cigarette smoking, controlled study, diet restriction, environmental exposure, enzyme inhibition, food contamination, food intake, gardening, health survey, human, information processing, major clinical study, mathematical analysis, prediction, priority journal, regression analysis, United States, urinalysis, adult, age, diet, environmental monitoring, sample size, smoking, urine, Nicotiana tabacum, Adolescent, Adult, Age Factors, Benzoates, Child, Diet, Diet Surveys, Environmental Monitoring, Humans, Pesticides, Regression Analysis, Sample Size, Smoking
Abstract

3-Phenoxybenzoic acid (3PBA), a pyrethroid metabolite, was detected in 75% of urine samples analyzed for pesticides in the U.S. National Health and Nutrition Examination Survey (NHANES) 1999-2002. NHANES also includes 24-hr diet data and information on household pesticide use, activities, occupation, demographics, and other exposure factors.The objective of our study was to explore the relative importance of diet versus nondiet predictors in explaining variability in urinary 3PBA. A secondary objective was to explore whether the NHANES data could be used to identify particular foods driving 3PBA levels.We divided subjects into child (6-10 years of age), teen (11-18 years), and adult (> or = 19 years) age groups and restricted our analyses to subjects in the morning sampling session who fasted for > or = 8 hr beforehand. Regression modeling consisted of several model-building steps and a final Tobit regression on the left-censored log 3PBA measurements. We also conducted bootstrap analyses to evaluate the stability of the regression parameters.Reported household pesticide use was not significantly associated with urinary 3PBA in any age group. Diet was significant for all three groups, and certain foods appeared to contribute more than others. Among adults, tobacco use was positively associated with 3PBA (p = 0.0326), and positive associations were suggested with the number of cytochrome p450-inhibiting medications taken (p = 0.0652) and minutes spent gardening (p = 0.0613) in the past month.Although exploratory, our findings underline the importance of collecting accurate data on household pesticide use and dietary intake when evaluating pyrethroid exposure-biomarker relationships.

Published
2008

48. Organophosphate Pesticide Exposure and Neurodevelopment in Young Mexican-American Children

Author

Eskenazi, Brenda, Marks, Amy R, Bradman, Asa, Harley, Kim, Barr, Dana B, Johnson, Caroline, Morga, Norma, and Jewell, Nicholas P

Subjects
Paediatrics, Biomedical and Clinical Sciences, Pediatric, Conditions Affecting the Embryonic and Fetal Periods, Endocrine Disruptors, Clinical Research, Women's Health, Prevention, Neurosciences, Reproductive health and childbirth, Good Health and Well Being, Adult, Age Factors, Agriculture, Attention, Child Development, Cognition, Cohort Studies, Female, Humans, Infant, Interviews as Topic, Male, Mexican Americans, Occupational Exposure, Organophosphates, Pesticides, Psychomotor Disorders, Bayley Scales of Infant Development, Child Behavior Checklist, DAPs, farmworker, neurodevelopment, organophosphates, pervasive developmental disorder, pesticides, Environmental Sciences, Medical and Health Sciences, Toxicology, Biomedical and clinical sciences, Environmental sciences, Health sciences
Abstract

BackgroundOrganophosphate (OP) pesticides are widely used in agriculture and homes. Animal studies suggest that even moderate doses are neurodevelopmental toxicants, but there are few studies in humans.ObjectivesWe investigated the relationship of prenatal and child OP urinary metabolite levels with children's neurodevelopment.MethodsParticipating children were from a longitudinal birth cohort of primarily Latino farm-worker families in California. We measured six nonspecific dialkylphosphate (DAP) metabolites in maternal and child urine as well as metabolites specific to malathion (MDA) and chlorpyrifos (TCPy) in maternal urine. We examined their association with children's performance at 6 (n = 396), 12 (n = 395), and 24 (n = 372) months of age on the Bayley Scales of Infant Development [Mental Development (MDI) and Psychomotor Development (PDI) Indices] and mother's report on the Child Behavior Checklist (CBCL) (n = 356).ResultsGenerally, pregnancy DAP levels were negatively associated with MDI, but child measures were positively associated. At 24 months of age, these associations reached statistical significance [per 10-fold increase in prenatal DAPs: beta = -3.5 points; 95% confidence interval (CI), -6.6 to -0.5; child DAPs: beta = 2.4 points; 95% CI, 0.5 to 4.2]. Neither prenatal nor child DAPs were associated with PDI or CBCL attention problems, but both prenatal and postnatal DAPs were associated with risk of pervasive developmental disorder [per 10-fold increase in prenatal DAPs: odds ratio (OR) = 2.3, p = 0.05; child DAPs OR = 1.7, p = 0.04]. MDA and TCPy were not associated with any outcome.ConclusionsWe report adverse associations of prenatal DAPs with mental development and pervasive developmental problems at 24 months of age. Results should be interpreted with caution given the observed positive relationship with postnatal DAPs.

Published
2007

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