2,600 results on '"Barosi A"'
Search Results
2. BINGO-ABDUS: a radiotelescope to unveil the dark sector of the Universe
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Abdalla, Elcio, Marins, Alessandro, Abdalla, Filipe, Vieira, Jordany, Formigari, Lucas, Queiroz, Amilcar R., Wang, Bin, Barosi, Luciano, Villela, Thyrso, Wuensche, Carlos A., Feng, Chang, Gurjao, Edmar, Landim, Ricardo, Novaes, Camila P., Santos, Joao R. L., and Zhang, Jiajung
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,General Relativity and Quantum Cosmology - Abstract
we review the Baryon Acoustic Oscillations from Integrated Neutral Gas Observations (BINGO) telescope, an international collaboration, led by Brazil and China, aiming to explore the Universe history through integrated post-reionization 21cm signals and fast radio emissions. For identifying individually fast radio sources, the Advanced Bingo Dark Universe Studies (ABDUS) project has been proposed and developed and will combine the current BINGO construction with the main single-dish telescope and stations of phased-array and outrigger., Comment: 23 pages, work presented in Syros, Greece, September 2022, to appear in Springer
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- 2023
3. The BINGO Project IX: Search for Fast Radio Bursts -- A Forecast for the BINGO Interferometry System
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Santos, Marcelo V. dos, Landim, Ricardo G., Hoerning, Gabriel A., Abdalla, Filipe B., Queiroz, Amilcar, Abdalla, Elcio, Wuensche, Carlos A., Wang, Bin, Barosi, Luciano, Villela, Thyrso, Marins, Alessandro, Feng, Chang, Gurjao, Edmar, Novaes, Camila P., Santos, Larissa C. O., Santos, Joao R. L., Zhang, Jiajun, Liccardo, Vincenzo, Zhang, Xue, Sang, Yu, Vieira, Frederico, and Motta, Pablo
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Baryon Acoustic Oscillations (BAO) from Integrated Neutral Gas Observations (BINGO) radio telescope will use the neutral Hydrogen emission line to map the Universe in the redshift range $0.127 \le z \le 0.449$, with the main goal of probing BAO. In addition, the instrument optical design and hardware configuration support the search for Fast Radio Bursts (FRBs). In this work, we propose the use of a BINGO Interferometry System (BIS) including new auxiliary, smaller, radio telescopes (hereafter \emph{outriggers}). The interferometric approach makes it possible to pinpoint the FRB sources in the sky. We present here the results of several BIS configurations combining BINGO horns with and without mirrors ($4$ m, $5$ m, and $6$ m) and 5, 7, 9, or 10 for single horns. We developed a new {\tt Python} package, the {\tt FRBlip}, which generates synthetic FRB mock catalogs and computes, based on a telescope model, the observed signal-to-noise ratio (S/N) that we used to compute numerically the detection rates of the telescopes and how many interferometry pairs of telescopes (\emph{baselines}) can observe an FRB. FRBs observed by more than one baseline are the ones whose location can be determined. We thus evaluate the performance of BIS regarding FRB localization. We found that BIS will be able to localize 23 FRBs yearly with single horn outriggers in the best configuration (using 10 outriggers of 6 m mirrors), with redshift $z \leq 0.96$; the full localization capability depends on the number and the type of the outriggers. Wider beams are best to pinpoint FRB sources because potential candidates will be observed by more baselines, while narrow beams look deep in redshift. The BIS can be a powerful extension of the regular BINGO telescope, dedicated to observe hundreds of FRBs during Phase 1. Many of them will be well localized with a single horn + 6 m dish as outriggers.(Abridged), Comment: 13 pages, 9 figures, 5 tables, accepted for publication in A&A
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- 2023
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4. BINGO-ABDUS: A Radiotelescope to Unveil the Dark Sector of the Universe
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Abdalla, Elcio, Marins, Alessandro, Abdalla, Filipe, Vieira, Jordany, Formigari, Lucas, Barosi, Luciano, Queiroz, Amilcar R., Villela, Thyrso, Wuensche, Carlos A., Wang, Bin, Feng, Chang, Gurjão, Edmar, Landim, Ricardo, Novaes, Camila P., Santos, João R. L., Zhang, Jiajun, Papantonopoulos, Eleftherios, editor, and Mavromatos, Nikolaos, editor
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- 2024
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5. Foreground removal and 21 cm signal estimates: comparing different blind methods for the BINGO Telescope
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Marins, Alessandro, Abdalla, Filipe B., Fornazier, Karin S. F., Abdalla, Elcio, Assis, Luiz H. F., Remazeilles, Mathieu, Wuensche, Carlos Alexandre, Barosi, Luciano, Queiroz, Amilcar R., Villela, Thyrso, Wang, Bin, Feng, Chang, Landim, Ricardo, Liccardo, Vincenzo, Novaes, Camila P., Santos, Larissa, Santos, Marcelo V. dos, and Zhang, Jiajun
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
BINGO will observe hydrogen distribution by means of the 21 cm line signal by drift-scan mapping through a tomographic analysis called \emph{Intensity Mapping} (IM) between 980 and 1260 MHz which aims at analyzing Dark Energy using \emph{Baryon Acoustic Oscillations}. In the same frequency range, there are several other unwanted signals as well as instrumental noise, contaminating the target signal. There are many component separation methods to reconstruct signals. Here, we used just three blind methods (FastICA, GNILC and GMCA), which explore different ways to estimate foregrounds' contribution from observed signals from the sky. Subsequently, we estimate 21 cm signal from its mixing with noise. We also analyzed how different number of simulations affect the quality of the estimation, as well as the effect of the binning on angular power spectrum to estimate 21 cm from the mixing with noise. For the BINGO sky range and sensitivity and the foreground model considered in the current simulation, we find that the effective dimension of the foreground subspace leading to best results is equal to three, composed of non-physical templates. At this moment of the pipeline configuration, using 50 or 400 simulations is statistically equivalent. It is also possible to reduce the number of multipoles by half to speed up the process and maintain the quality of results. All three algorithms used to perform foreground removal yielded statistically equivalent results for estimating the 21cm signal when we assume 400 realizations and GMCA and FastICA's mixing matrix dimensions equal to three. However, concerning computational cost in this stage of the BINGO pipeline, FastICA is faster than other algorithms. A new comparison will be necessary when the time-ordered-data and map-making are available.
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- 2022
6. The BINGO project VIII: On the recoverability of the BAO signal on HI intensity mapping simulations
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Novaes, Camila Paiva, Zhang, Jiajun, de Mericia, Eduardo J., Abdalla, Filipe B., Liccardo, Vincenzo, Wuensche, Carlos A., Delabrouille, Jacques, Remazeilles, Mathieu, Santos, Larissa, Landim, Ricardo G., Abdalla, Elcio, Barosi, Luciano, Queiroz, Amilcar, Villela, Thyrso, Wang, Bin, Brito, Francisco A., Costa, André A., Ferreira, Elisa G. M., Marins, Alessandro, and Santos, Marcelo V. dos
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
A new and promising technique for observing the Universe and study the dark sector is the intensity mapping of the redshifted 21cm line of neutral hydrogen (HI). The BINGO radio telescope will use the 21cm line to map the Universe in the redshift range $0.127 \le z \le 0.449$, in a tomographic approach, with the main goal of probing BAO. This work presents the forecasts of measuring the transversal BAO signal during the BINGO Phase 1 operation. We use two clustering estimators, the two-point angular correlation function (ACF) and the angular power spectrum (APS), and a template-based method to model the ACF and APS estimated from simulations of the BINGO region and extract the BAO information. The tomographic approach allows the combination of redshift bins to improve the template fitting performance. We find that each clustering estimator shows different sensitivities to specific redshift ranges, although both of them perform better at higher redshifts. In general, the APS estimator provides slightly better estimates, with smaller uncertainties and larger probability of detection of the BAO signal, achieving $\gtrsim 90$\% at higher redshifts. We investigate the contribution from instrumental noise and residual foreground signals and find that the former has the greater impact, getting more significant as the redshift increases, in particular the APS estimator. Indeed, including noise in the analysis increases the uncertainty up to a factor of $\sim 2.2$ at higher redshifts. Foreground residuals, in contrast, do not significantly affect our final uncertainties. In summary, our results show that, even including semi-realistic systematic effects, BINGO has the potential to successfully measure the BAO scale in radio frequencies. (Abridged), Comment: 18 pages, 6 figures. Submitted to A&A
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- 2022
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7. The Gordian knot: ruxolitinib or transplants for high-risk myelofibrosis
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Robert Peter Gale and Giovanni Barosi
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Not available.
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- 2024
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8. Testing synchrotron models and frequency resolution in BINGO 21 cm simulated maps using GNILC
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de Mericia, Eduardo J., Santos, Larissa, Wuensche, Carlos Alexandre, Liccardo, Vincenzo, Novaes, Camila P., Delabrouille, Jacques, Remazeilles, Mathieu, Abdalla, Filipe, Feng, Chang, Barosi, Luciano, Queiroz, Amilcar, Villela, Thyrso, Wang, Bin, Zhang, Jiajun, Costa, Andre A., Ferreira, Elisa G. M., Landim, Ricardo G., Marins, Alessandro, and Santos, Marcelo V. dos
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
To recover the 21 cm hydrogen line, it is essential to separate the cosmological signal from the much stronger foreground contributions at radio frequencies. The BINGO radio telescope is designed to measure the 21 cm line and detect BAOs using the intensity mapping technique. This work analyses the performance of the GNILC method, combined with a power spectrum debiasing procedure. The method was applied to a simulated BINGO mission, building upon previous work from the collaboration. It compares two different synchrotron emission models and different instrumental configurations, in addition to the combination with ancillary data to optimize both the foreground removal and recovery of the 21 cm signal across the full BINGO frequency band, as well as to determine an optimal number of frequency bands for the signal recovery. We have produced foreground emissions maps using the Planck Sky Model, the cosmological Hi emission maps are generated using the FLASK package and thermal noise maps are created according to the instrumental setup. We apply the GNILC method to the simulated sky maps to separate the Hi plus thermal noise contribution and, through a debiasing procedure, recover an estimate of the noiseless 21 cm power spectrum. We found a near optimal reconstruction of the Hi signal using a 80 bins configuration, which resulted in a power spectrum reconstruction average error over all frequencies of 3%. Furthermore, our tests showed that GNILC is robust against different synchrotron emission models. Finally, adding an extra channel with CBASS foregrounds information, we reduced the estimation error of the 21 cm signal. The optimisation of our previous work, producing a configuration with an optimal number of channels for binning the data, impacts greatly the decisions regarding BINGO hardware configuration before commissioning., Comment: Submitted to A&A
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- 2022
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9. A rare presentation of heart failure with preserved ejection fraction
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Donadoni, Mattia, Petullà, Marina, Del Medico, Marta, Barosi, Alberto, and Wu, Maddalena Alessandra
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- 2023
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10. The BINGO Project IV: Simulations for mission performance assessment and preliminary component separation steps
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Liccardo, Vincenzo, de Mericia, Eduardo J., Wuensche, Carlos A., Abdalla, Elcio, Abdalla, Filipe B., Barosi, Luciano, Brito, Francisco A., Queiroz, Amilcar, Villela, Thyrso, Peel, Michael W., Wang, Bin, Costa, Andre A., Ferreira, Elisa G. M., Fornazier, Karin S. F., Novaes, Camila P., Santos, Larissa, Santos, Marcelo V. dos, Remazeilles, Mathieu, Zhang, Jiajun, Dickinson, Clive, Harper, Stuart, Landim, Ricardo G., Marins, Alessandro, and Vieira, Frederico
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The large-scale distribution of neutral hydrogen (HI) in the Universe is luminous through its 21 cm emission. The goal of the Baryon Acoustic Oscillations from Integrated Neutral Gas Observations -- BINGO -- radio telescope is to detect baryon acoustic oscillations (BAOs) at radio frequencies through 21 cm intensity mapping (IM). The telescope will span the redshift range 0.127 $< z <$ 0.449 with an instantaneous field-of-view of $14.75^{\circ} \times 6.0^{\circ}$. In this work we investigate different constructive and operational scenarios of the instrument by generating sky maps as they would be produced by the instrument. In doing this we use a set of end-to-end IM mission simulations. The maps will additionally be used to evaluate the efficiency of a component separation method (GNILC). We have simulated the kind of data that would be produced in a single-dish IM experiment such as BINGO. According to the results obtained, we have optimized the focal plane design of the telescope. In addition, the application of the GNILC method on simulated data shows that it is feasible to extract the cosmological signal across a wide range of multipoles and redshifts. The results are comparable with the standard principal component analysis method., Comment: 16 pages. Version to appear in A&A
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- 2021
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11. The BINGO Project VI: HI Halo Occupation Distribution and Mock Building
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Zhang, Jiajun, Motta, Pablo, Novaes, Camila P., Abdalla, Filipe B., Costa, Andre A., Wang, Bin, Zhu, Zhenghao, Shan, Chenxi, Xu, Haiguang, Abdalla, Elcio, Barosi, Luciano, Brito, Francisco A., Queiroz, Amilcar, Villela, Thyrso, Wuensche, Carlos A., Ferreira, Elisa G. M., Fornazier, Karin S. F., Marins, Alessandro, Santos, Larissa, Santos, Marcelo Vargas dos, Landim, Ricardo G., and Liccardo, Vincenzo
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
BINGO (Baryon Acoustic Oscillations from Integrated Neutral Gas Observations.) is a radio telescope designed to survey from 980 MHz to 1260 MHz, observe the neutral Hydrogen (HI) 21-cm line and detect BAO (Baryon Acoustic Oscillation) signal with Intensity Mapping technique. Here we present our method to generate mock maps of the 21-cm Intensity Mapping signal covering the BINGO frequency range and related test results. (Abridged), Comment: 16 pages, 20 figures, 1 table. Accepted for publication in A&A
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- 2021
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12. The BINGO Project VII: Cosmological Forecasts from 21cm Intensity Mapping
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Costa, Andre A., Landim, Ricardo G., Novaes, Camila P., Xiao, Linfeng, Ferreira, Elisa G. M., Abdalla, Filipe B., Wang, Bin, Abdalla, Elcio, Battye, Richard A., Marins, Alessandro, Wuensche, Carlos A., Barosi, Luciano, Brito, Francisco A., Queiroz, Amilcar R., Villela, Thyrso, Fornazier, Karin S. F., Liccardo, Vincenzo, Santos, Larissa, Santos, Marcelo V. dos, and Zhang, Jiajun
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The 21cm line of neutral hydrogen (HI) opens a new avenue in our exploration of the structure and evolution of the Universe. It provides complementary data to the current large-scale structure observations with different systematics, and thus it will be used to improve our understanding of the $\Lambda$CDM model. Among several radio cosmological surveys designed to measure this line, BINGO is a single-dish telescope mainly designed to detect baryon acoustic oscillations (BAOs) at low redshifts ($0.127< z<0.449$). Our goal is to assess the fiducial BINGO setup and its capabilities of constraining the cosmological parameters, and to analyze the effect of different instrument configurations. We used the Phase 1 fiducial configuration of the BINGO telescope to perform our cosmological forecasts. In addition, we investigated the impact of several instrumental setups, taking into account some instrumental systematics, and different cosmological models. Combining BINGO with Planck temperature and polarization data, the projected constraint improves from a $13\%$ and $25\%$ precision measurement at the $68\%$ confidence level with Planck only to $1\%$ and $3\%$ for the Hubble constant and the dark energy equation of state (EoS), respectively, within the wCDM model. Assuming a Chevallier-Polarski-Linder parameterization, the EoS parameters have standard deviations given by $\sigma_{w_0} = 0.30$ and $\sigma_{w_a} = 1.2$, which are improvements on the order of $30\%$ with respect to Planck alone. Also, we can access information about the HI density and bias, obtaining $\sim 8.5\%$ and $\sim 6\%$ precision, respectively, assuming they vary with redshift at three independent bins. The fiducial BINGO configuration will be able to extract significant cosmological information from the HI distribution and provide constraints competitive with current and future cosmological surveys. (Abridged), Comment: 22 pages, accepted for publication in A&A
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- 2021
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13. The BINGO Project I: Baryon Acoustic Oscillations from Integrated Neutral Gas Observations
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Abdalla, Elcio, Ferreira, Elisa G. M., Landim, Ricardo G., Costa, Andre A., Fornazier, Karin S. F., Abdalla, Filipe B., Barosi, Luciano, Brito, Francisco A., Queiroz, Amilcar R., Villela, Thyrso, Wang, Bin, Wuensche, Carlos A., Marins, Alessandro, Novaes, Camila P., Liccardo, Vincenzo, Shan, Chenxi, Zhang, Jiajun, Zhang, Zhongli, Zhu, Zhenghao, Browne, Ian, Delabrouille, Jacques, Santos, Larissa, Santos, Marcelo V. dos, Xu, Haiguang, Anton, Sonia, Battye, Richard, Chen, Tianyue, Dickinson, Clive, Ma, Yin-Zhe, Maffei, Bruno, de Mericia, Eduardo J., Motta, Pablo, Otobone, Carlos H. N., Peel, Michael W., Roychowdhury, Sambit, Remazeilles, Mathieu, Ribeiro, Rafael M., Sang, Yu, Santos, Joao R. L., Santos, Juliana F. R. dos, Silva, Gustavo B., Vieira, Frederico, Vieira, Jordany, Xiao, Linfeng, Zhang, Xue, and Zhu, Yongkai
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Observations of the redshifted 21-cm line of neutral hydrogen (HI) are a new and powerful window of observation that offers us the possibility to map the spatial distribution of cosmic HI and learn about cosmology. BINGO (Baryon Acoustic Oscillations [BAO] from Integrated Neutral Gas Observations) is a new unique radio telescope designed to be one of the first to probe BAO at radio frequencies. BINGO has two science goals: cosmology and astrophysics. Cosmology is the main science goal and the driver for BINGO's design and strategy. The key of BINGO is to detect the low redshift BAO to put strong constraints in the dark sector models. Given the versatility of the BINGO telescope, a secondary goal is astrophysics, where BINGO can help discover and study Fast Radio Bursts (FRB) and other transients, Galactic and extragalactic science. In this paper, we introduce the latest progress of the BINGO project, its science goals, describing the scientific potential of the project in each science and the new developments obtained by the collaboration. We introduce the BINGO project and its science goals and give a general summary of recent developments in construction, science potential and pipeline development obtained by the BINGO collaboration in the past few years. We show that BINGO will be able to obtain competitive constraints for the dark sector, and also that will allow for the discovery of several FRBs in the southern hemisphere. The capacity of BINGO in obtaining information from 21-cm is also tested in the pipeline introduced here. There is still no measurement of the BAO in radio, and studying cosmology in this new window of observations is one of the most promising advances in the field. The BINGO project is a radio telescope that has the goal to be one of the first to perform this measurement and it is currently being built in the northeast of Brazil. (Abridged), Comment: 23 pages. To appear in A&A
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- 2021
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14. The BINGO Project III: Optical design and optimisation of the focal plane
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Abdalla, Filipe B., Marins, Alessandro, Motta, Pablo, Abdalla, Elcio, Ribeiro, Rafael M., Wuensche, Carlos A., Delabrouille, Jacques, Fornazier, Karin S. F., Liccardo, Vincenzo, Maffei, Bruno, de Mericia, Eduardo J., Otobone, Carlos H. N., Santos, Juliana F. R. dos, Silva, Gustavo B., Vieira, Jordany, Barretos, João A. M., Barosi, Luciano, Brito, Francisco A., Queiroz, Amilcar R., Villela, Thyrso, Wang, Bin, Costa, Andre A., Ferreira, Elisa G. M., Landim, Ricardo G., Novaes, Camila Paiva, Peel, Michael W., Santos, Larissa, Santos, Marcelo V. dos, and Zhang, Jiajun
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The BINGO telescope was designed to measure the fluctuations of the 21-cm radiation arising from the hyperfine transition of neutral hydrogen and aims to measure the Baryon Acoustic Oscillations (BAO) from such fluctuations, therefore serving as a pathfinder to future deeper intensity mapping surveys. The requirements for the Phase 1 of the projects consider a large reflector system (two 40 m-class dishes in a crossed-Dragone configuration), illuminating a focal plane with 28 horns to measure the sky with two circular polarisations in a drift scan mode to produce measurements of the radiation in intensity as well as the circular polarisation. In this paper we present the optical design for the instrument. We describe the intensity and polarisation properties of the beams and the optical arrangement of the horns in the focal plane to produce a homogeneous and well-sampled map after the end of Phase 1. Our analysis provides an optimal model for the location of the horns in the focal plane, producing a homogeneous and Nyquist sampled map after the nominal survey time. We arrive at an optimal configuration for the optical system, including the focal plane positioning and the beam behavior of the instrument. We present an estimate of the expected side lobes both for intensity and polarisation, as well as the effect of band averaging on the final side lobes. The cross polarisation leakage values for the final configuration allow us to conclude that the optical arrangement meets the requirements of the project. We conclude that the chosen optical design meets the requirements for the project in terms of polarisation purity, area coverage as well as homogeneity of coverage so that BINGO can perform a successful BAO experiment. We further conclude that the requirements on the placement and r.m.s. error on the mirrors are also achievable so that a successful experiment can be conducted.(Abridged), Comment: 22 pages. Accepted for publication in A&A
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- 2021
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15. The BINGO Project II: Instrument Description
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Wuensche, Carlos A., Villela, Thyrso, Abdalla, Elcio, Liccardo, Vincenzo, Vieira, Frederico, Browne, Ian, Peel, Michael W., Radcliffe, Christopher, Abdalla, Filipe B., Marins, Alessandro, Barosi, Luciano, Brito, Francisco A., Queiroz, Amilcar R., Wang, Bin, Costa, Andre A., Ferreira, Elisa G. M., Fornazier, Karin S. F., Landim, Ricardo G., Novaes, Camila P., Santos, Larissa, Santos, Marcelo V. dos, Zhang, Jiajun, Chen, Tianyue, Delabrouille, Jacques, Dickinson, Clive, de Gasperis, Giancarlo, Gurjão, Edmar C., Harper, Stuart, Ma, Yin-Zhe, Machado, Telmo, Maffei, Bruno, de Mericia, Eduardo J., Monstein, Christian, Motta, Pablo, Otobone, Carlos H. N., Reitano, Luiz A., Remazeilles, Mathieu, Roychowdhury, Sambit, Santos, João R. L., Serres, Alexandre J. R., Souza, Andreia P., Strauss, Cesar, Vieira, Jordany, and Xu, Haiguang
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The measurement of diffuse 21-cm radiation from the hyperfine transition of neutral hydrogen (HI signal) in different redshifts is an important tool for modern cosmology. However, detecting this faint signal with non-cryogenic receivers in single-dish telescopes is a challenging task. The BINGO (Baryon Acoustic Oscillations from Integrated Neutral Gas Observations) radio telescope is an instrument designed to detect baryonic acoustic oscillations (BAOs) in the cosmological HI signal, in the redshift interval $0.127 \le z \le 0.449$. This paper describes the BINGO radio telescope, including the current status of the optics, receiver, observational strategy, calibration, and the site. BINGO has been carefully designed to minimize systematics, being a transit instrument with no moving dishes and 28 horns operating in the frequency range $980 \le \nu \le 1260$ MHz. Comprehensive laboratory tests were conducted for many of the BINGO subsystems and the prototypes of the receiver chain, horn, polarizer, magic tees, and transitions have been successfully tested between 2018 - 2020. The survey was designed to cover $\sim 13\%$ of the sky, with the primary mirror pointing at declination $\delta=-15^{\circ}$. The telescope will see an instantaneous declination strip of $14.75^{\circ}$. The results of the prototype tests closely meet those obtained during the modeling process, suggesting BINGO will perform according to our expectations. After one year of observations with a $60\%$ duty cycle and 28 horns, BINGO should achieve an expected sensitivity of 102 $\mu K$ per 9.33 MHz frequency channel, one polarization, and be able to measure the HI power spectrum in a competitive time frame., Comment: 13 pages, accepted for publication in A&A
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- 2021
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16. The BINGO Project V: Further steps in Component Separation and Bispectrum Analysis
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Fornazier, Karin S. F., Abdalla, Filipe B., Remazeilles, Mathieu, Vieira, Jordany, Marins, Alessandro, Abdalla, Elcio, Santos, Larissa, Delabrouille, Jacques, Mericia, Eduardo, Landim, Ricardo G., Ferreira, Elisa G. M., Barosi, Luciano, Brito, Francisco A., Queiroz, Amilcar R., Villela, Thyrso, Wang, Bin, Wuensche, Carlos A., Costa, Andre A., Liccardo, Vincenzo, Novaes, Camila Paiva, Peel, Michael W., Santos, Marcelo V. dos, and Zhang, Jiajun
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Observing the neutral hydrogen distribution across the Universe via redshifted 21cm line intensity mapping constitutes a powerful probe for cosmology. However, the redshifted 21cm signal is obscured by the foreground emission from our Galaxy and other extragalactic foregrounds. This paper addresses the capabilities of the BINGO survey to separate such signals. Specifically, this paper looks in detail at the different residuals left over by foreground components, shows that a noise-corrected spectrum is unbiased, and shows that we understand the remaining systematic residuals by analyzing nonzero contributions to the three-point function. We use the generalized needlet internal linear combination, which we apply to sky simulations of the BINGO experiment for each redshift bin of the survey. We present our recovery of the redshifted 21cm signal from sky simulations of the BINGO experiment, including foreground components. We test the recovery of the 21cm signal through the angular power spectrum at different redshifts, as well as the recovery of its non-Gaussian distribution through a bispectrum analysis. We find that non-Gaussianities from the original foreground maps can be removed down to, at least, the noise limit of the BINGO survey with such techniques. Our component separation methodology allows us to subtract the foreground contamination in the BINGO channels down to levels below the cosmological signal and the noise, and to reconstruct the 21cm power spectrum for different redshift bins without significant loss at multipoles $20 \lesssim \ell \lesssim 500$. Our bispectrum analysis yields strong tests of the level of the residual foreground contamination in the recovered 21cm signal, thereby allowing us to both optimize and validate our component separation analysis. (Abridged), Comment: 20 pages. Version accepted in A&A
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- 2021
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17. Type 1 CALR mutation allele frequency correlates with CD34/CXCR4 expression in myelofibrosis-type megakaryocyte dysplasia: A mechanism of disease progression?
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Giovanni Barosi, Rita Campanelli, Paolo Catarsi, Carlotta Abbà, Adriana Carolei, Margherita Massa, Robert Peter Gale, and Vittorio Rosti
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2024
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18. Methodological challenges in the development of endpoints for myelofibrosis clinical trials
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Barosi, Giovanni, Tefferi, Ayalew, Gangat, Naseema, Szuber, Natasha, Rambaldi, Alessandro, Odenike, Olatoyosi, Kröger, Nicolaus, Gagelmann, Nico, Talpaz, Moshe, Kantarjian, Hagop, and Gale, Robert Peter
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- 2024
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19. Baryon Acoustic Oscillations from Integrated Neutral Gas Observations: an instrument to observe the 21cm hydrogen line in the redshift range 0.13 $<$ z $<$ 0.45 -- status update
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Wuensche, Carlos A., Abdalla, Elcio, Abdalla, Filipe Batoni, Barosi, Luciano, Wang, Bin, An, Rui, Barreto, João Alberto de Moraes, Battye, Richard, Brito, Franciso A., Browne, Ian, Correia, Daniel Souza, Costa, André Alencar, Delabrouille, Jacques, Dickinson, Clive, Feng, Chang, Ferreira, Elisa, Fornazier, Karin, de Gasperis, Giancarlo, Gutierrez, Priscila, Harper, Stuart, Landim, Ricardo G., Liccardo, Vincenzo, Ma, Yin-Zhe, Machado, Telmo, Maffei, Bruno, Marins, Alessandro, Mendes, Milena Martins Machado, Merícia, Eduardo, Monstein, Christian, Motta, Pablo, Novaes, Camila P., Otobone, Carlos Henrique do Nascimento, Peel, Michael, Queiroz, Amilcar, Radcliffe, Christopher, Remazeilles, Mathieu, Ribeiro, Rafael M. G., Sang, Yu, Santos, Juliana Fernandes Rossi dos, Santos, Larissa, Santos, Marcelo V., Shan, Chenxi, Silva, Gustavo Bezerra, Vieira, Frederico, Vieira, Jordany, Villela, Thyrso, Xiao, Linfeng, Yang, Weiqiang, Zhang, Jiajun, Zhang, Xue, and Zhu, Zenghao
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
BINGO (BAO from Integrated Neutral Gas Observations) is a unique radio telescope designed to map the intensity of neutral hydrogen distribution at cosmological distances, making the first detection of Baryon Acoustic Oscillations (BAO) in the frequency band 980 MHz - 1260 MHz, corresponding to a redshift range $0.127 < z < 0.449$. BAO is one of the most powerful probes of cosmological parameters and BINGO was designed to detect the BAO signal to a level that makes it possible to put new constraints on the equation of state of dark energy. The telescope will be built in Para\'iba, Brazil and consists of two $\thicksim$ 40m mirrors, a feedhorn array of 28 horns, and no moving parts, working as a drift-scan instrument. It will cover a $15^{\circ}$ declination strip centered at $\sim \delta=-15^{\circ}$, mapping $\sim 5400$ square degrees in the sky. The BINGO consortium is led by University of S\~ao Paulo with co-leadership at National Institute for Space Research and Campina Grande Federal University (Brazil). Telescope subsystems have already been fabricated and tested, and the dish and structure fabrication are expected to start in late 2020, as well as the road and terrain preparation., Comment: Presented in the BRICS Astronomy Working Group Meeting (Rio de Janeiro, Brazil, 2019) and published in the Anais da Academia Brasileira de Ci\^encias (2021). Updated captions of Figure 3 and data in Table 1, compared to the published version
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- 2021
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20. Indication and management of allogeneic haematopoietic stem-cell transplantation in myelofibrosis: updated recommendations by the EBMT/ELN International Working Group
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Kröger, Nicolaus, Bacigalupo, Andrea, Barbui, Tiziano, Ditschkowski, Markus, Gagelmann, Nico, Griesshammer, Martin, Gupta, Vikas, Hamad, Nada, Harrison, Claire, Hernandez-Boluda, Juan Carlos, Koschmieder, Steffen, Jain, Tania, Mascarenhas, John, Mesa, Ruben, Popat, Uday R, Passamonti, Francesco, Polverelli, Nicola, Rambaldi, Alessandro, Robin, Marie, Salit, Rachel B, Schroeder, Thomas, Scott, Bart L, Tamari, Roni, Tefferi, Ayalew, Vannucchi, Alessandro M, McLornan, Donal P, and Barosi, Giovanni
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- 2024
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21. VEGFA rs3025039 is associated with phenotype severity of myelofibrosis‐type megakaryocyte dysplasia
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Giovanni Barosi, Paolo Catarsi, Rita Campanelli, Margherita Massa, Adriana Carolei, Carlotta Abbà, Annalisa deSilvestri, Robert Peter Gale, and Vittorio Rosti
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2023
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22. X-linked hypophosphatemia, obesity and arterial hypertension: data from the XLH21 study
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Bloudeau, Louisa, Linglart, Agnès, Flammier, Sacha, Portefaix, Aurélie, Bertholet-Thomas, Aurélia, Eddiry, Sanaa, and Barosi, Anna
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Genetic disorders -- Diagnosis -- Care and treatment ,Obesity -- Complications and side effects -- Distribution ,Renal hypertension -- Risk factors -- Prevention ,Company distribution practices ,Health - Abstract
Background The underlying mechanisms of obesity in X-linked hypophosphatemia (XLH) are not known. We aimed to evaluate whether FGF21, an endocrine FGF involved in the regulation of carbohydrate-lipid metabolism, could be involved. Methods We performed a prospective multicenter cross-sectional study comparing FGF23, Klotho, and FGF21 levels in teenagers with XLH compared to healthy controls (VITADOS cohort) after matching for age, gender, and puberty. Non-parametric tests were performed (results presented as median (min-max)). Results A total of 40 XLH teenagers (n = 20 Standard Of Care, SOC, n = 20 burosumab) were included. While patients receiving burosumab displayed increased BMI as compared to patients receiving SOC, systolic blood pressure expressed as percentile was progressively and significantly lower when comparing the three groups: 77 (4-99) in SOC, 47 (9-98) in burosumab, and 28 (1-94) in controls (p = 0.007). When compared to patients receiving SOC, patients receiving burosumab displayed significantly increased phosphate and 1,25(OH)2D levels. We found increased Klotho levels in patients receiving burosumab. No differences were found for either carbohydrate-lipid biomarkers or FGF21 between the three groups. A total of 21 XLH patients (53%) had insulin resistance (HOMA > 2.4, N = 10 SOC, N = 11 burosumab). Conclusion FGF21 does not explain obesity/overweight in XLH. Of note, this study was performed in France in 2018-2019, early after the approval authorizing burosumab only in case of severe XLH despite SOC. As such, the data on systolic blood pressure highlighting a possible impact of burosumab to decrease blood pressure as well as increase Klotho levels deserve further studies given their potential effect on long-term cardiovascular risk. Graphical Abstract A higher resolution version of the Graphical abstract is available as Supplementary information, Author(s): Louisa Bloudeau [sup.1] , Agnès Linglart [sup.2] , Sacha Flammier [sup.1] , Aurélie Portefaix [sup.3] , Aurélia Bertholet-Thomas [sup.1] , Sanaa Eddiry [sup.4] , Anna Barosi [sup.2] , Jean-Pierre [...]
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- 2023
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23. Myelofibrosis-type megakaryocyte dysplasia (MTMD) as a distinct category of BCR::ABL-negative myeloproliferative neoplasms. Challenges and perspectives
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Barosi, Giovanni, Rosti, Vittorio, and Gale, Robert Peter
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- 2023
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24. Towards a personalized preventive strategy of Herpes zoster infection in patients with hematologic diseases or hematopoietic stem cell transplant recipients: a position paper from an ad hoc Italian expert panel
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Corrado Girmenia, Fabio Ciceri, Paolo Corradini, Antonio Cuneo, Fortunato D’Ancona, Pellegrino Musto, Antonio Maria Risitano, Maria Teresa Voso, Adriano Venditti, and Giovanni Barosi
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
The identification of patients at high risk of herpes zoster (HZ) requiring a prevention strategy with antiviral prophylaxis and anti-HZ vaccine is a clinically relevant issue in patients with immunological impairment. Absence of trials comparing vaccination to pharmacological prophylaxis or defining their sequential use makes the optimal prevention strategy uncertain. This article presents the results of group discussion among an ad hoc constituted panel of experts aimed to review the literature regarding antiviral prophylaxis and vaccine efficacy and safety in populations with malignant and non-malignant hematological diseases, and submitted to hematopoietic stem cell transplantation. The panel used the consensus methodology and proposed solutions for prevention strategy producing advice for the management of the most relevant unmet clinical needs. Such a comprehensive overview aims to support at the practice of HZ pharmacological and vaccine prevention and informing the design and the need of implementation of new studies in the field.
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- 2023
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25. Brazilian Community Report on Dark Matter
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Abdalla, E., Albuquerque, I. F. M., Alves, A., Barosi, L., Bazetto, M. C. Q., Batista, R. C., Bernardes, C. A., Bonifazi, C., Borges, H. A., Brito, F. A., Caramês, T. R. P., Casarini, L., Cogollo, D., Dias, A. G., Esmaili, A., Ferreira, M. M., da Silveira, G. Gil, Guzzo, M. M., Hadjimichef, D., de Holanda, P. C., Kemp, E., Lessa, A., Lichtenstein, G., Machado, A. A., Makler, M., Marra, V., Matheus, R. D., Mercadante, P. G., de Melo, T. B., Nishi, C., Nepomuceno, A., Novaes, S. F., Pimentel, V. L., Pinheiro, P. R. D., Pires, C. A., Queiroz, A. R., Queiroz, F. S., Rangel, M. ~S., Rodrigues, D. C., Rodrigues, J. G., de Souza, V., da Silva, P. S. Rodrigues, Siqueira, C., Segreto, E., Sanchez-Vega, B. L., Rosenfeld, R., Santos, J. R. L., Santos, A. C. O., Silva, R., Sokolowska, D., Teles, P. R., Tomei, T. R. F. P., Valdiviesso, G. A., Vasconcelos, P., and Viana, A.
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High Energy Physics - Phenomenology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
This white paper summarizes the activities of the Brazilian community concerning dark matter physics and highlights the importance of financial support to Brazilian groups that are deeply involved in experimental endeavours. The flagships of the Brazilian dark matter program are the Cherenkov Telescope Array, DARKSIDE, SBN and LHC experiments, but we emphasize that smaller experiments such as DAMIC and CONNIE constitute important probes to dark sectors as well and should receive special attention. Small experimental projects showing the potential to probe new regions of parameter space of dark matter models are encouraged. On the theoretical and phenomenological side, some groups are devoted to astrophysical aspects such as the dark matter density profile while others explore the signature of dark matter models at colliders, direct and indirect detection experiments. In summary, the Brazilian dark matter community that was born not long ago has grown tremendously in the past years and now plays an important role in the hunt for a dark matter particle., Comment: 10 pages, 1 figure
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- 2019
26. Baryon acoustic oscillations from Integrated Neutral Gas Observations: Broadband corrugated horn construction and testing
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Wuensche, C. A., Reitano, L., Peel, M. W., Browne, I. W. A., Maffei, B., Abdalla, E., Radcliffe, C., Abdalla, F., Barosi, L., Liccardo, V., Mericia, E., Pisano, G., Strauss, C., Vieira, F., Villela, T., and Wang, B.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Baryon acoustic oscillations from Integrated Neutral Gas Observations (BINGO) telescope is a 40-m~class radio telescope under construction that has been designed to measure the large-angular-scale intensity of HI emission at 980--1260 MHz and hence to constrain dark energy parameters. A large focal plane array comprising of 1.7-metre diameter, 4.3-metre length corrugated feed horns is required in order to optimally illuminate the telescope. Additionally, very clean beams with low sidelobes across a broad frequency range are required, in order to facilitate the separation of the faint HI emission from bright Galactic foreground emission. Using novel construction methods, a full-sized prototype horn has been assembled. It has an average insertion loss of around 0.15 dB across the band, with a return loss around -25 dB. The main beam is Gaussian with the first sidelobe at around $-25 dB. A septum polariser to separate the signal into the two hands of circular polarization has also been designed, built and tested., Comment: This is a pre-print of an article published in Experimental Astronomy. The final authenticated version is available online at: https://doi.org/10.1007/s10686-020-09666-9
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- 2019
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27. Management of infection in PNH patients treated with eculizumab or other complement inhibitors: Unmet clinical needs
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Girmenia, Corrado, Barcellini, Wilma, Bianchi, Paola, Di Bona, Eros, Iori, Anna Paola, Notaro, Rosario, Sica, Simona, Zanella, Alberto, De Vivo, Antonio, Barosi, Giovanni, and Risitano, Antonio
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- 2023
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28. Increased risk of thrombosis in JAK2 V617F-positive patients with primary myelofibrosis and interaction of the mutation with the IPSS score
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Tiziano Barbui, Arianna Ghirardi, Alessandra Carobbio, Arianna Masciulli, Greta Carioli, Alessandro Rambaldi, Maria Chiara Finazzi, Marta Bellini, Elisa Rumi, Daniele Vanni, Oscar Borsani, Francesco Passamonti, Barbara Mora, Marco Brociner, Paola Guglielmelli, Chiara Paoli, Alberto Alvarez-Larran, Ana Triguero, Marta Garrote, Helna Pettersson, Björn Andréasson, Giovanni Barosi, and Alessandro Maria Vannucchi
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2022
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29. Baryon acoustic oscillations from Integrated Neutral Gas Observations: Radio frequency interference measurements and telescope site selection
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Peel, M. W., Wuensche, C. A., Abdalla, E., Anton, S., Barosi, L., Browne, I. W. A., Caldas, M., Dickinson, C., Fornazier, K. S. F., Monstein, C., Strauss, C., Tancredi, G., and Villela, T.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Baryon acoustic oscillations from Integrated Neutral Gas Observations (BINGO) telescope is a new 40-m class radio telescope to measure the large-angular-scale intensity of Hi emission at 980-1260 MHz to constrain dark energy parameters. As it needs to measure faint cosmological signals at the milliKelvin level, it requires a site that has very low radio frequency interference (RFI) at frequencies around 1 GHz. We report on measurement campaigns across Uruguay and Brazil to find a suitable site, which looked at the strength of the mobile phone signals and other radio transmissions, the location of wind turbines, and also included mapping airplane flight paths. The site chosen for the BINGO telescope is a valley at Serra do Urubu, a remote part of Paraiba in North-East Brazil, which has sheltering terrain. During our measurements with a portable receiver we did not detect any RFI in or near the BINGO band, given the sensitivity of the equipment. A radio quiet zone around the selected site has been requested to the Brazilian authorities ahead of the telescope construction., Comment: Preprint of an article accepted in the Journal of Astronomical Instrumentation, copyright 2018 World Scientific Publishing Company https://www.worldscientific.com/worldscinet/jai
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- 2018
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30. Cells coexpressing both myeloid and endothelial markers are detectable in the spleen and bone marrow of patients with primary myelofibrosis
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Campanelli, Rita, Abbà, Carlotta, Carolei, Adriana, Catarsi, Paolo, Barosi, Giovanni, Massa, Margherita, and Rosti, Vittorio
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- 2022
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31. Unmet Clinical Needs in the Management of Idiopathic Multicentric Castleman Disease: A Consensus-based Position Paper From an ad hoc Expert Panel
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Pier Luigi Zinzani, Marco Paulli, Luca Arcaini, Emanuel Della Torre, Simone Ferrero, Amalia Figuera, Ferdinando Frigeri, Maurizio Martelli, Elena Sabattini, Riccardo Scarpa, and Giovanni Barosi
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Castleman disease describes a group of heterogeneous clinicopathological disorders now included in the tumor-like lesions with B-cell predominance of the World Health Organization classification. Managing idiopathic multicentric Castleman disease (iMCD) is challenging, because few systematic studies or comparative randomized clinical trials have been conducted. International, consensus evidence-based guidelines for iMCD were published in 2018, but gaps in the therapeutic options for difficult-to-treat patients, who do not respond to siltuximab and other conventional therapies, still exist. This article presents the results of group discussion among an ad hoc constituted Panel of Italian experts to identify and address unmet clinical needs (UCNs) in managing iMCD. Recommendations on the appropriateness of clinical decisions and proposals for new research concerning the identified UCNs were issued through formalized multiple-step procedures after a comprehensive analysis of the scientific literature. The following key UCNs were addressed: strengthening the diagnostic certainty in iMCD patients before planning first-line therapy; management of siltuximab therapy; choice and management of immune-modulating, or chemotherapy agents in patients resistant/intolerant to siltuximab therapy. While most of the conclusions reached by the Panel are consistent with the existing guidelines, some alternative therapeutic options were stressed, and the discussion contributed to bringing forth the issues that need further investigation. Hopefully, this comprehensive overview will improve the practice of iMCD and inform the design and implementation of new studies in the field.
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- 2023
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32. Appropriate management of polycythaemia vera with cytoreductive drug therapy: European LeukemiaNet 2021 recommendations
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Marchetti, Monia, Vannucchi, Alessandro Maria, Griesshammer, Martin, Harrison, Claire, Koschmieder, Steffen, Gisslinger, Heinz, Álvarez-Larrán, Alberto, De Stefano, Valerio, Guglielmelli, Paola, Palandri, Francesca, Passamonti, Francesco, Barosi, Giovanni, Silver, Richard T, Hehlmann, Rüdiger, Kiladjian, Jean-Jacques, and Barbui, Tiziano
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- 2022
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33. Management of infectious risk of daratumumab therapy in multiple myeloma: A consensus-based position paper from an ad hoc Italian expert panel
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Girmenia, Corrado, Cavo, Michele, Corso, Alessandro, Di Raimondo, Francesco, Musto, Pellegrino, Offidani, Massimo, Petrucci, Maria Teresa, Rosato, Antonio, and Barosi, Giovanni
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- 2022
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34. Deep Learning Detection of Cardiac Akinesis in Echocardiograms
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Bitetto, Alessandro, Bianchi, Elena, Dondi, Piercarlo, Bianchi, Luca, Tolgyesi, Janos, Ferri, Diego, Lombardi, Luca, Cerchiello, Paola, Marceca, Azzurra, Barosi, Alberto, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Del Bimbo, Alberto, editor, Cucchiara, Rita, editor, Sclaroff, Stan, editor, Farinella, Giovanni Maria, editor, Mei, Tao, editor, Bertini, Marco, editor, Escalante, Hugo Jair, editor, and Vezzani, Roberto, editor
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- 2021
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35. Echocardiography in COVID-19 Pandemic: Clinical Findings and the Importance of Emerging Technology
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Barosi, Alberto, Bergamaschi, Luca, Cusmano, Ignazio, Gasperetti, Alessio, Schiavone, Marco, and Gherbesi, Elisa
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- 2022
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36. Unmet Clinical Needs and Management Recommendations for Blastic Plasmacytoid Dendritic Cell Neoplasm: A Consensus-based Position Paper From an Ad Hoc International Expert Panel
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Livio Pagano, Pier Luigi Zinzani, Stefano Pileri, Pietro Quaglino, Branko Cuglievan, Emilio Berti, Naveen Pemmaraju, Francesco Onida, Rein Willemze, Alberto Orfao, and Giovanni Barosi
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a hematological malignancy characterized by recurrent skin nodules, an aggressive clinical course with rapid involvement of hematological organs, and a poor prognosis with overall survival. The rarity of the disease results in a few large-scale studies, a lack of controlled clinical trials for its management, and a lack of evidence-based guidelines. Here, we present a review of unmet clinical needs on the management of BPDCN by a panel of eleven experts involved in the research and clinical practice of BPDCN. Recommendations and proposals were achieved by multiple-step formalized procedures to reach a consensus after a comprehensive analysis of the scientific literature. The panel analyzed the critical issues of diagnostic pathway, prognostic stratification, therapy for young and fit patients and elderly and unfit patients, indication for allotransplant and for autotransplant, indication for central nervous system prophylaxis, and management of pediatric BPDCN patients. For each of these issues, consensus opinions were provided and, when appropriate, proposals for advancement in clinical practice were addressed. The hope is that this comprehensive overview will serve to improve the practice of BPDCN and inform the design and implementation of new studies in the field.
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- 2023
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37. Increased risk of thrombosis in JAK2 V617F-positive patients with primary myelofibrosis and interaction of the mutation with the IPSS score
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Barbui, Tiziano, Ghirardi, Arianna, Carobbio, Alessandra, Masciulli, Arianna, Carioli, Greta, Rambaldi, Alessandro, Finazzi, Maria Chiara, Bellini, Marta, Rumi, Elisa, Vanni, Daniele, Borsani, Oscar, Passamonti, Francesco, Mora, Barbara, Brociner, Marco, Guglielmelli, Paola, Paoli, Chiara, Alvarez-Larran, Alberto, Triguero, Ana, Garrote, Marta, Pettersson, Helna, Andréasson, Björn, Barosi, Giovanni, and Vannucchi, Alessandro Maria
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- 2022
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38. Deep Learning Detection of Cardiac Akinesis in Echocardiograms.
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Alessandro Bitetto, Elena Bianchi, Piercarlo Dondi, Luca Bianchi, Janos Tolgyesi, Diego Ferri, Luca Lombardi, Paola Cerchiello, Azzurra Marceca, and Alberto Barosi
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- 2020
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39. Early echocardiographic findings in patients hospitalized for COVID-19 pneumonia: a prospective, single center study
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Ceriani, Elisa, Marceca, Azzurra, Lanfranchi, Antonio, De Vita, Stefano, Schiavon, Riccardo, Casella, Francesco, Torzillo, Daniela, del Medico, Marta, Ruggiero, Diego, Barosi, Alberto, and Cogliati, Chiara
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- 2021
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40. Idiopathic splanchnic vein thrombosis: is it really idiopathic?
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Giovanni Barosi
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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41. A randomized study of pomalidomide vs placebo in persons with myeloproliferative neoplasm-associated myelofibrosis and RBC-transfusion dependence.
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Tefferi, A, Al-Ali, H, Barosi, G, Devos, T, Gisslinger, H, Jiang, Q, Kiladjian, J-J, Mesa, R, Passamonti, F, McMullin, M, Ribrag, V, Schiller, G, Vannucchi, A, Zhou, D, Reiser, D, Zhong, J, and Gale, R
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Adult ,Aged ,Aged ,80 and over ,Biomarkers ,Erythrocyte Transfusion ,Female ,Humans ,Immunologic Factors ,Male ,Middle Aged ,Myeloproliferative Disorders ,Phenotype ,Primary Myelofibrosis ,Thalidomide ,Treatment Outcome ,Workflow - Abstract
RBC-transfusion dependence is common in persons with myeloproliferative neoplasm (MPN)-associated myelofibrosis. The objective of this study was to determine the rates of RBC-transfusion independence after therapy with pomalidomide vs placebo in persons with MPN-associated myelofibrosis and RBC-transfusion dependence. Two hundred and fifty-two subjects (intent-to-treat (ITT) population) including 229 subjects confirmed by central review (modified ITT population) were randomly assigned (2:1) to pomalidomide or placebo. Trialists and subjects were blinded to treatment allocation. Primary end point was proportion of subjects achieving RBC-transfusion independence within 6 months. One hundred and fifty-two subjects received pomalidomide and 77 placebo. Response rates were 16% (95% confidence interval (CI), 11, 23%) vs 16% (8, 26%; P=0.87). Response in the pomalidomide cohort was associated with ⩽4 U RBC/28 days (odds ratio (OR)=3.1; 0.9, 11.1), age ⩽65 (OR=2.3; 0.9, 5.5) and type of MPN-associated myelofibrosis (OR=2.6; 0.7, 9.5). Responses in the placebo cohort were associated with ⩽4 U RBC/28 days (OR=8.6; 0.9, 82.3), white blood cell at randomization >25 × 109/l (OR=4.9; 0.8, 28.9) and interval from diagnosis to randomization >2 years (OR=4.9; 1.1, 21.9). Pomalidomide was associated with increased rates of oedema and neutropenia but these adverse effects were manageable. Pomalidomide and placebo had similar RBC-transfusion-independence response rates in persons with MPN-associated RBC-transfusion dependence.
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- 2017
42. Proposals for revised International Working Group–European LeukemiaNet criteria for anemia response in myelofibrosis
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Tefferi, Ayalew, Barosi, Giovanni, Passamonti, Francesco, Hernandez-Boluda, Juan-Carlos, Bose, Prithviraj, Döhner, Konstanze, Ellis, Martin, Gangat, Naseema, Garcia, Jacqueline S., Gisslinger, Heinz, Gotlib, Jason, Guglielmelli, Paola, Gupta, Vikas, Harrison, Claire, Hexner, Elizabeth O., Hobbs, Gabriela S., Kiladjian, Jean-Jacques, Koschmieder, Steffen, Kroger, Nicolaus, Kuykendall, Andrew T., Loscocco, Giuseppe G., Mascarenhas, John, Masarova, Lucia, Mesa, Ruben, Mora, Barbara, Odenike, Olatoyosi, Oh, Stephen T., Pardanani, Animesh, Patel, Anand, Pemmaraju, Naveen, Rambaldi, Alessandro, Rampal, Raajit, Sirhan, Shireen, Szuber, Natasha, Talpaz, Moshe, Vachhani, Pankit J., Vannucchi, Alessandro M., and Barbui, Tiziano
- Abstract
•An international panel of 38 experts and clinical trialists in MF participated in the preparation of the current document.•New definitions of transfusion status, gender-specific hemoglobin thresholds, and criteria for major and minor responses are submitted.
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- 2024
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43. Transplant indications, guidelines and recommendations: Caveat Emptor
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Gale, Robert Peter and Barosi, Giovanni
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- 2022
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44. Gene expression profile correlates with molecular and clinical features in patients with myelofibrosis
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Rontauroli, Sebastiano, Castellano, Sara, Guglielmelli, Paola, Zini, Roberta, Bianchi, Elisa, Genovese, Elena, Carretta, Chiara, Parenti, Sandra, Fantini, Sebastian, Mallia, Selene, Tavernari, Lara, Sartini, Stefano, Mirabile, Margherita, Mannarelli, Carmela, Gesullo, Francesca, Pacilli, Annalisa, Pietra, Daniela, Rumi, Elisa, Salmoiraghi, Silvia, Mora, Barbara, Villani, Laura, Grilli, Andrea, Rosti, Vittorio, Barosi, Giovanni, Passamonti, Francesco, Rambaldi, Alessandro, Malcovati, Luca, Cazzola, Mario, Bicciato, Silvio, Tagliafico, Enrico, Vannucchi, Alessandro M., and Manfredini, Rossella
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- 2021
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45. Elevated plasma EDA fibronectin in primary myelofibrosis is determined by high allele burden of JAK2V617F mutation and strongly predicts splenomegaly progression
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Alessandro Malara, Cristian Gruppi, Margherita Massa, Maria Enrica Tira, Vittorio Rosti, Alessandra Balduini, and Giovanni Barosi
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primary myelofibrosis ,splenomegaly ,neoangiogenesis ,extra domain A ,fibronectin ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
In primary myelofibrosis, extra-domain A fibronectin (EDA-FN), the result of alternative splicing of FN gene, sustains megakaryocyte proliferation and confers a pro-inflammatory phenotype to bone marrow cell niches. In this work we assessed the levels of circulating EDA-FN in plasma samples of 122 patients with primary myelofibrosis. Patients with a homozygous JAK2V617F genotype displayed the higher level of plasma EDA-FN. Increased EDA-FN levels were associated with anemia, elevated high-sensitivity C-reactive protein, bone marrow fibrosis and splanchnic vein thrombosis at diagnosis. While no correlation was observed with CD34+ hematopoietic stem cell mobilization, elevated blood level of EDA-FN at diagnosis was a predictor of large splenomegaly (over 10 cm from the left costal margin) outcome. Thus, EDA-FN expression in primary myelofibrosis may represent the first marker of disease progression, and a novel target to treat splenomegaly.
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- 2022
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46. Thrombosis in multiple myeloma: risk stratification, antithrombotic prophylaxis, and management of acute events. A consensus-based position paper from an ad hoc expert panel
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Valerio De Stefano, Alessandra Larocca, Monica Carpenedo, Michele Cavo, Francesco Di Raimondo, Anna Falanga, Massimo Offidani, Maria Teresa Petrucci, Marco Ruggeri, Roberto Mario Santi, and Giovanni Barosi
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
The introduction of new therapeutic agents for multiple myeloma (MM), including proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies, has improved the outcomes of patients but, in parallel, has changed the frequency and epidemiology of thrombotic events. Thrombosis is now a significant cause of morbidity and mortality in MM patients, and optimal thromboprophylaxis is far from being reached. Moving from the recognition that the above issue represents an unmet clinical need, an expert panel assessed the scientific literature and composed a framework of recommendations for improving thrombosis control in patients who are candidates for active treatment for MM. The panel generated key clinical questions using the criterion of clinical relevance through a Delphi process. It explored four domains, i.e., thrombotic risk factors and risk stratification, primary thromboprophylaxis, management of acute thrombotic events, and secondary thromboprophylaxis. The recommendations issued may assist hematologists in minimizing the risk of thrombosis and guarantee adherence to treatment in patients with MM who are candidates for active treatment.
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- 2022
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47. Circulating Polymorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSCs) Have a Biological Role in Patients with Primary Myelofibrosis.
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Campanelli, Rita, Carolei, Adriana, Catarsi, Paolo, Abbà, Carlotta, Boveri, Emanuela, Paulli, Marco, Gentile, Raffaele, Morosini, Monica, Albertini, Riccardo, Mantovani, Stefania, Massa, Margherita, Barosi, Giovanni, and Rosti, Vittorio
- Subjects
RESEARCH funding ,MYELOID-derived suppressor cells ,MYELOPROLIFERATIVE neoplasms ,OXIDATIVE stress ,IMMUNE system ,CHRONIC diseases ,BONE marrow diseases ,SEPSIS ,MYELOFIBROSIS ,INFLAMMATION ,CYTOKINES ,GENETICS - Abstract
Simple Summary: Myeloid-derived suppressor cells (MDSCs) are immature cells that expand in the circulation of patients with cancer, sepsis or chronic inflammation, modulate the immune response against cancer (favoring tumor onset and progression) and promote neoangiogenesis. These premises suggest that MDSCs could be involved in the pathogenesis of primary myelofibrosis (PMF) (a myeloproliferative neoplasm characterized by chronic inflammation and extensive neoangiogenesis in bone marrow and spleen). In this paper, we found that (1) MDSCs are increased both in the circulation and in the spleen of PMF patients and strongly correlate with disease progression; and (2) reduced CXCR4 expression on MDSCs along with increased plasmatic SDF-1α can be involved in their mobilization. These findings suggest that circulating MDSCs can be considered a parameter of disease severity and set MDSCs as potential new targets for cancer therapy. Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by a chronic inflammatory state that plays a relevant role in the disease pathogenesis (as proven by high levels of inflammatory cytokines with prognostic significance and by a persistent oxidative stress) and by extensive neoangiogenesis in bone marrow (BM) and spleen. Myeloid-derived suppressor cells (MDSCs) are immature cells that expand in patients with cancer, sepsis or chronic inflammation, favoring tumor onset and progression mainly through the decrease in immune surveillance and the promotion of neoangiogenesis. In this paper, we evaluated the presence of circulating MDSCs in PMF patients, the plasmatic factors involved in their mobilization/expansion and the correlations with laboratory, genetic and clinical parameters. The data indicated that MDSCs could have a relevant role in PMF as a new pathogenic mechanism contributing to explaining the phenotypic diversity observed during the clinical course of the disease, or a potential new target for personalized treatment. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms
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Di Buduo, Christian A., Abbonante, Vittorio, Marty, Caroline, Moccia, Francesco, Rumi, Elisa, Pietra, Daniela, Soprano, Paolo M., Lim, Dmitry, Cattaneo, Daniele, Iurlo, Alessandra, Gianelli, Umberto, Barosi, Giovanni, Rosti, Vittorio, Plo, Isabelle, Cazzola, Mario, and Balduini, Alessandra
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- 2020
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49. The BINGO Project
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dos Santos, Marcelo V., primary, Landim, Ricardo G., additional, Hoerning, Gabriel A., additional, Abdalla, Filipe B., additional, Queiroz, Amilcar, additional, Abdalla, Elcio, additional, Wuensche, Carlos A., additional, Wang, Bin, additional, Barosi, Luciano, additional, Villela, Thyrso, additional, Marins, Alessandro, additional, Feng, Chang, additional, Gurjão, Edmar, additional, Novaes, Camila P., additional, Santos, Larissa C. O., additional, Santos, João R.L., additional, Zhang, Jiajun, additional, Liccardo, Vincenzo, additional, Zhang, Xue, additional, Sang, Yu, additional, Vieira, Frederico, additional, and Motta, Pablo, additional
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- 2024
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50. Reduced CXCR4-expression on CD34-positive blood cells predicts outcomes of persons with primary myelofibrosis
- Author
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Barosi, Giovanni, Rosti, Vittorio, Catarsi, Paolo, Villani, Laura, Abbà, Carlotta, Carolei, Adriana, Magrini, Umberto, Gale, Robert Peter, Massa, Margherita, and Campanelli, Rita
- Published
- 2021
- Full Text
- View/download PDF
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