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8 results on '"Baroque, Alejandro C."'

1. CHInese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study (CHIMES-E): A Multicenter Study of Long-Term Efficacy

Author

Venketasubramanian, Narayanaswamy, Young, Sherry H., Tay, San San, Umapathi, Thirugnanam, Lao, Annabelle Y., Gan, Herminigildo H., Baroque, Alejandro C., II, Navarro, Jose C., Chang, Hui Meng, Advincula, Joel M., Muengtaweepongsa, Sombat, Chan, Bernard P.L., Chua, Carlos L., Wijekoon, Nirmala, de Silva, Asita H., Hiyadan, John Harold B., Suwanwela, Nijasri C., Wong, Lawrence K.S., Poungvarin, Niphon, Eow, Gaik Bee, Lee, Chun Fan, and Chen, Christopher L.H.

Published
2015
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4. Effects of MLC601 on Early Vascular Events in Patients After Stroke: The CHIMES Study

Author

Chen, Christopher L.H., Venketasubramanian, Narayanaswamy, Lee, Chun Fan, Wong, K.S. Lawrence, Bousser, Marie-Germaine, Navarro, Jose C., Gan, Herminigildo H., Lao, Annabelle Y., Baroque, Alejandro C., II, Lokin, Johnny, Hiyadan, John Harold B., Sarfati, Ma. Socorro, Fangonillo, Randolph John, Ambasing, Neil, Chua, Carlos L., San Jose, Ma. Cristina, Advincula, Joel M., Berame, Eli John, Canete, Maria Teresa, Venketasubramanian, Narayanaswamy, Young, Sherry H.Y., Mamauag, Marlie Jane, Tay, San San, Pande, Shrikant, Thirugnanam, Umapathi, Singh, Rajinder, Chang, Hui Meng, De Silva, Deidre Anne, Chan, Bernard P.L., Sharma, Vijay, Luen, Teoh Hock, Poungvarin, Niphon, Muengtaweepongsa, Sombat, Towanabut, Somchai, Suwanwela, Nijasri C., Chotickanuchit, Songkram, Chankrachang, Siwaporn, Nitinun, Samart, de Silva, H. Asita, Ranawake, Udaya, Wijekoon, Nirmala, Wong, K.S. Lawrence, and Eow, Gaik Bee

Published
2013
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6. Chinese Medicine Neuroaid Efficacy on Stroke Recovery: A Double-Blind, Placebo-Controlled, Randomized Study

Author

Chen, Christopher L.H., Young, Sherry H.Y., Gan, Herminigildo H., Singh, Rajinder, Lao, Annabelle Y., Baroque, Alejandro C., II, Chang, Hui Meng, Hiyadan, John Harold B., Chua, Carlos L., Advincula, Joel M., Muengtaweepongsa, Sombat, Chan, Bernard P.L., de Silva, H. Asita, Towanabut, Somchai, Suwanwela, Nijasri C., Poungvarin, Niphon, Chankrachang, Siwaporn, Wong, K.S. Lawrence, Eow, Gaik Bee, Navarro, Jose C., Venketasubramanian, Narayanaswamy, Lee, Chun Fan, and Bousser, Marie-Germaine

Published
2013
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8. Durability of the beneficial effect of MLC601 (NeuroAiD™) on functional recovery among stroke patients from the Philippines in the CHIMES and CHIMES-E studies.

Author

Navarro JC, Chen CL, Lee CF, Gan HH, Lao AY, Baroque AC 2nd, Hiyadan JH, Chua CL, San Jose MC, Advincula JM, and Venketasubramanian N

Subjects
Female, Follow-Up Studies, Humans, Interviews as Topic, Male, Medicine, Chinese Traditional, Middle Aged, Odds Ratio, Philippines, Recovery of Function drug effects, Severity of Illness Index, Stroke Rehabilitation, Time Factors, Time-to-Treatment, Treatment Outcome, Drugs, Chinese Herbal therapeutic use, Neuroprotective Agents therapeutic use, Stroke drug therapy
Abstract

Background and Aim A pre-specified country analysis of subjects from the Philippines in the CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) Study showed significantly improved functional and neurological outcomes on MLC601 at month (M) 3. We aimed to assess these effects on long-term functional recovery in the Filipino cohort. Methods The CHIMES-E (extension) Study evaluated subjects who completed three months of randomized placebo-controlled treatment in CHIMES up to two years. Blinding of treatment allocation was maintained and all subjects received standard stroke care and rehabilitation. Modified Rankin Score (mRS) and Barthel Index (BI) were assessed in-person at M3 and by telephone at M6, M12, M18, M24. Odds ratios (OR) with corresponding 95% confidence intervals (CI) for functional recovery using ordinal analysis of mRS and for achieving functional independence (mRS 0-1 or BI ≥ 95) at each time point were calculated, adjusting for age, sex, baseline National Institute of Health Stroke Scale (NIHSS), onset-to-treatment time (OTT) and pre-stroke mRS. Results The 378 subjects (MLC601 192, placebo 186) included in CHIMES-E from the Philippines (mean age 60.2 ± 11.1) had more women ( p < 0.001), worse baseline NIHSS ( p < 0.001) and longer onset to treatment time ( p = 0.002) compared to other countries. Baseline characteristics were similar between treatment groups. The treatment effect of MLC601 seen at M3 peaked at M6 with OR for mRS shift of 1.53 (95% CI 1.05-2.22), mRS dichotomy 0-1 of 1.77 (95% CI 1.10-2.83), and BI ≥ 95 of 1.87 (95% CI 1.16-3.02). The beneficial effect persisted up to M24. Conclusion The beneficial effect of MLC601 seen at M3 in the Filipino cohort is durable up to two years after stroke.

Published
2017
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