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45 results on '"Baronti, Cécile"'

2. Preclinical in vivo assessment of the activity of AZD7442 anti-SARS-CoV-2 monoclonal antibodies against Omicron sublineages

Author

Driouich, Jean-Sélim, Cochin, Maxime, Lingas, Guillaume, Luciani, Léa, Baronti, Cécile, Bernadin, Ornéllie, Gilles, Magali, Villarroel, Paola Mariela Saba, Moureau, Grégory, Petit, Paul-Rémi, Dupont, Axelle, Izopet, Jacques, Kamar, Nassim, Autran, Brigitte, Paintaud, Gilles, Caillard, Sophie, le Bourgeois, Amandine, Richez, Christophe, Couzi, Lionel, Xhaard, Aliénor, Marjanovic, Zora, Avouac, Jerome, Jacquet, Caroline, Anglicheau, Dany, Cheminant, Morgane, Nguyen, Stéphanie, Terrier, Benjamin, Gottenberg, Jacques Eric, Besson, Caroline, Letrou, Sophie, Tine, Josephine, Basilua, Joe Miantezila, Angoulvant, Denis, Tardivon, Coralie, Blancho, Gilles, Martin-Blondel, Guillaume, Yazdanpanah, Yazdan, Mentré, France, Lévy, Vincent, Touret, Franck, Guedj, Jérémie, de Lamballerie, Xavier, and Nougairède, Antoine

Published
2024
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7. Severe fever with thrombocytopenia syndrome virus (SFTSV) in Thailand: Seroprevalence study in humans and molecular detection in ticks

Author

Villarroel, Paola Mariela Saba, primary, Chaiphongpachara, Tanawat, additional, Nurtop, Elif, additional, Laojun, Sedthapong, additional, Pangpoo-nga, Tassanee, additional, Songhong, Thanaphon, additional, Supungul, Dolruethai, additional, Baronti, Cécile, additional, Thirion, Laurence, additional, Leaungwutiwong, Pornsawan, additional, de Lamballerie, Xavier, additional, Missé, Dorothée, additional, and Wichit, Sineewanlaya, additional

Published
2024
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10. Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals

Author

Thébault, Stéphanie, primary, Lejal, Nathalie, additional, Dogliani, Alexis, additional, Donchet, Amélie, additional, Urvoas, Agathe, additional, Valerio-Lepiniec, Marie, additional, Lavie, Muriel, additional, Baronti, Cécile, additional, Touret, Franck, additional, Da Costa, Bruno, additional, Bourgon, Clara, additional, Fraysse, Audrey, additional, Saint-Albin-Deliot, Audrey, additional, Morel, Jessica, additional, Klonjkowski, Bernard, additional, de Lamballerie, Xavier, additional, Dubuisson, Jean, additional, Roussel, Alain, additional, Minard, Philippe, additional, Le Poder, Sophie, additional, Meunier, Nicolas, additional, and Delmas, Bernard, additional

Published
2022
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16. Structure and functionality in flavivirus NS-proteins: Perspectives for drug design

Author

Bollati, Michela, Alvarez, Karin, Assenberg, René, Baronti, Cécile, Canard, Bruno, Cook, Shelley, Coutard, Bruno, Decroly, Etienne, de Lamballerie, Xavier, Gould, Ernest A., Grard, Gilda, Grimes, Jonathan M., Hilgenfeld, Rolf, Jansson, Anna M., Malet, Hélène, Mancini, Erika J., Mastrangelo, Eloise, Mattevi, Andrea, Milani, Mario, Moureau, Grégory, Neyts, Johan, Owens, Raymond J., Ren, Jingshan, Selisko, Barbara, Speroni, Silvia, Steuber, Holger, Stuart, David I., Unge, Torsten, and Bolognesi, Martino

Published
2010
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20. SARS-CoV-2 20I/501Y.V1 variant in the hamster model

Author

Cochin, Maxime, primary, Luciani, Léa, additional, Touret, Franck, additional, Driouich, Jean-Sélim, additional, Petit, Paul-Rémi, additional, Moureau, Grégory, additional, Baronti, Cécile, additional, Thirion, Laurence, additional, Maes, Piet, additional, Boudewijns, Robbert, additional, Neyts, Johan, additional, de Lamballerie, Xavier, additional, and Nougairède, Antoine, additional

Published
2021
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22. Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(E)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs

Author

Abuduaini, Tuniyazi, primary, Roy, Vincent, additional, Marlet, Julien, additional, Gaudy-Graffin, Catherine, additional, Brand, Denys, additional, Baronti, Cécile, additional, Touret, Franck, additional, Coutard, Bruno, additional, McBrayer, Tamara R., additional, Schinazi, Raymond F., additional, and Agrofoglio, Luigi A., additional

Published
2021
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23. Differential susceptibility and innate immune response of Aedes aegypti and Aedes albopictus to the Haitian strain of the Mayaro Virus

Author

Diop, Fode, Alout, Haoues, Diagne, Cheikh Tidiane, Bengue, Michèle, Baronti, Cécile, Hamel, Rodolphe, Talignani, Loic, Liegeois, Florian, Pompon, Julien, Vargas, Ronald E. Morales, Nougairede, Antoine, and Missé, Dorothée

Subjects
Médecine vétérinaire et santé animal, education, fungi, virus diseases, Veterinary medicine and animal Health, arbovirus, Mayaro virus, Aedes aegypti, Aedes albopictus, chondrocytes, ML26A, Niemann-Pick type C1
Abstract

Mayaro (MAYV) is an emerging arthropod-borne virus belonging to the Alphavirus genus of the Togaviridae family. Although forest-dwelling Haemagogus mosquitoes have been considered as its main vector, the virus has also been detected in circulating Aedes ssp mosquitoes. Here we assess the susceptibility of Aedes aegypti and Aedes albopictus to infection with MAYV and their innate immune response at an early stage of infection. Aedes albopictus was more susceptible to infection with MAYV than Ae. aegypti. Analysis of transcript levels of twenty immunity-related genes by real-time PCR in the midgut of both mosquitoes infected with MAYV revealed increased expression of several immune genes, including CLIP-domain serine proteases, the anti-microbial peptides defensin A, E, cecropin E, and the virus inducible gene. The regulation of certain genes appeared to be Aedes species-dependent. Infection of Ae. aegypti with MAYV resulted in increased levels of myeloid differentiation2-related lipid recognition protein (ML26A) transcripts, as compared to Ae. albopictus. Increased expression levels of thio-ester-containing protein 22 (TEP22) and Niemann-Pick type C1 (NPC1) gene transcripts were observed in infected Ae. albopictus, but not Ae. aegypti. The differences in these gene expression levels during MAYV infection could explain the variation in susceptibility observed in both mosquito species.

Published
2019

24. Mayaro Virus Infects Human Chondrocytes and Induces the Expression of Arthritis-Related Genes Associated with Joint Degradation

Author

Bengue, Michèle, primary, Ferraris, Pauline, additional, Baronti, Cécile, additional, Diagne, Cheikh Tidiane, additional, Talignani, Loïc, additional, Wichit, Sineewanlaya, additional, Liegeois, Florian, additional, Bisbal, Catherine, additional, Nougairède, Antoine, additional, and Missé, Dorothée, additional

Published
2019
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27. External Quality Assessment for Zika Virus Molecular Diagnostic Testing, Brazil

Author

Fischer, Carlo, primary, Pedroso, Celia, additional, Mendrone, Alfredo, additional, Bispo de Filippis, Ana Maria, additional, Vallinoto, Antonio Carlos Rosário, additional, Ribeiro, Bergmann Morais, additional, Durigon, Edison Luiz, additional, Marques, Ernesto T.A., additional, Campos, Gubio S., additional, Viana, Isabelle F.T., additional, Levi, José Eduardo, additional, Scarpelli, Luciano Cesar, additional, Nogueira, Mauricio Lacerda, additional, Bastos, Michele de Souza, additional, Souza, Nathalia C. Santiago, additional, Khouri, Ricardo, additional, Lira, Sanny M. Costa, additional, Komninakis, Shirley Vasconcelos, additional, Baronti, Cécile, additional, Charrel, Rémi N., additional, Kümmerer, Beate M., additional, Drosten, Christian, additional, Brites, Carlos, additional, de Lamballerie, Xavier, additional, Niedrig, Matthias, additional, Netto, Eduardo Martins, additional, and Drexler, Jan Felix, additional

Published
2018
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28. Molecular epidemiology of dengue viruses in three provinces of Lao PDR, 2006-2010

Author

Castonguay-Vanier, Josée, primary, Klitting, Raphaëlle, additional, Sengvilaipaseuth, Onanong, additional, Piorkowski, Géraldine, additional, Baronti, Cécile, additional, Sibounheuang, Bountoy, additional, Vongsouvath, Manivanh, additional, Chanthongthip, Anisone, additional, Thongpaseuth, Soulignasack, additional, Mayxay, Mayfong, additional, Phommasone, Koukeo, additional, Douangdala, Phouvieng, additional, Inthalath, Saythong, additional, Souvannasing, Phouthalavanh, additional, Newton, Paul N., additional, de Lamballerie, Xavier, additional, and Dubot-Pérès, Audrey, additional

Published
2018
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32. Development of generic Taqman PCR and RT-PCR assays for the detection of DNA and mRNA of beta-actin-encoding sequences in a wide range of animal species

Author

Piorkowski, G., Baronti, Cécile, de Lamballerie, Xavier, de Fabritus, L., Bichaud, L., Pastorino, B. A., and Bessaud, M.

Subjects
Taqman assay, Next generation, sequencing, ACTB gene, Housekeeping gene, Actin
Abstract

As a member of the European Virus Archive (EVA) consortium, our laboratory is developing and maintaining a large collection of viruses. This collection implies the use of a panel of cell lines originating from various animal species. In order to make easier the handling of such a large panel of cell lines, wide spectrum real-time PCR and RT-PCR assays were developed to allow the detection and the quantification of DNA and mRNA of beta-actin, one of the most commonly used eukaryotic housekeeping genes. By using two degenerated primers and a unique probe, these two assays were shown to detect nucleic acids of a panel of vertebrate and invertebrate cell lines commonly used in animal virology. This panel included human, monkey, rodent, dog, pig, fish, batrachian, mosquito and tick cell lines. Additionally, the two assays amplified successfully beta-actin-encoding sequences of sandflies. Sensitivity evaluation performed on synthetic DNA and RNA sequences showed that the two assays were very sensitive and suitable for accurate quantification. The two assays constitute together a convenient method suitable for multiple purposes. They can be used for instance to estimate the amount of contaminating cellular genetic material prior to sequence-independent amplification of viral genomes achieved before high-throughput sequencing, to evaluate the efficiency of DNase and/or RNase treatments performed on cellular extract and to check nucleic acid extraction by using beta-actin-encoding sequences as endogenous control. This assay will constitute a precious tool for virologists working with multiple cell lines or animal models.

Published
2014

33. Arenaviruses and hantaviruses : from epidemiology and genomics to antivirals

Author

Charrel, R., Coutard, B., Baronti, Cécile, Canard, B., Nougairede, A., Frangeul, A., Morin, B., Jamal, S., Schmidt, C. L., Hilgenfeld, R., Klempa, B., and de Lamballerie, Xavier

Subjects
Zoonosis, viruses, virus diseases, Arenavirus, Antiviral therapy, Hantavirus
Abstract

The arenaviruses and hantaviruses are segmented genome RNA viruses that are hosted by rodents. Due to their association with rodents, they are globally widespread and can infect humans via direct or indirect routes of transmission, causing considerable human morbidity and mortality. Nevertheless, despite their obvious and emerging importance as pathogens, there are currently no effective antiviral drugs (except ribavirin which proved effective against Lassa virus) with which to treat humans infected by any of these viruses. The EU-funded VIZIER project (Comparative Structural Genomics of Viral Enzymes Involved in Replication) was instigated with an ultimate view of contributing to the development of antiviral therapies for RNA viruses, including the arenaviruses and bunyaviruses. This review highlights some of the major features of the arenaviruses and hantaviruses that have been investigated during recent years. After describing their classification and epidemiology, we review progress in understanding the genomics as well as the structure and function of replicative enzymes achieved under the VIZIER program and the development of new disease control strategies.

Published
2011

35. Viral aetiology influenza like illnesses in Santa Cruz, Bolivia (2010–2012)

Author

Delangue, Julie, primary, Roca Sanchez, Yelin, additional, Piorkowski, Géraldine, additional, Bessaud, Maël, additional, Baronti, Cécile, additional, Thirion-Perrier, Laurence, additional, Mafayle, Roxana Loayza, additional, Ardaya, Cinthia Avila, additional, Aguilera, Gabriela Añez, additional, Guzman, Jimmy Revollo, additional, Riera, Javier Lora, additional, and de Lamballerie, Xavier, additional

Published
2014
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36. Dengue Virus Type 3 Infection in Traveler Returning from West Africa

Author

Ninove, Laetitia, Parola, Philippe, Baronti, Cécile, De Lamballerie, Xavier, Gautret, Philippe, Doudier, Barbara, and Charrel, Rémi N.

Subjects
Dengue, traveler, Côte d’Ivoire, West Africa, surveillance, letter, viruses, Letters to the Editor
Published
2009

39. The 2C putative helicase of echovirus 30 adopts a hexameric ring-shaped structure

Author

Papageorgiou, Nicolas, primary, Coutard, Bruno, additional, Lantez, Violaine, additional, Gautron, Eric, additional, Chauvet, Olivier, additional, Baronti, Cécile, additional, Norder, Heléne, additional, de Lamballerie, Xavier, additional, Heresanu, Vasile, additional, Ferté, Nathalie, additional, Veesler, Stéphane, additional, Gorbalenya, Alexander E., additional, and Canard, Bruno, additional

Published
2010
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40. The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

Author

Morin, Benjamin, primary, Coutard, Bruno, additional, Lelke, Michaela, additional, Ferron, François, additional, Kerber, Romy, additional, Jamal, Saïd, additional, Frangeul, Antoine, additional, Baronti, Cécile, additional, Charrel, Rémi, additional, de Lamballerie, Xavier, additional, Vonrhein, Clemens, additional, Lescar, Julien, additional, Bricogne, Gérard, additional, Günther, Stephan, additional, and Canard, Bruno, additional

Published
2010
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43. Differential Susceptibility and Innate Immune Response of Aedes aegypti and Aedes albopictus to the Haitian Strain of the Mayaro Virus.

Author

Diop F, Alout H, Diagne CT, Bengue M, Baronti C, Hamel R, Talignani L, Liegeois F, Pompon J, Morales Vargas RE, Nougairède A, and Missé D

Subjects
Aedes immunology, Animals, Antimicrobial Cationic Peptides genetics, Antimicrobial Cationic Peptides metabolism, Gene Expression immunology, Gene Expression Profiling, Mosquito Vectors virology, Real-Time Polymerase Chain Reaction, Serine Proteases genetics, Serine Proteases metabolism, Aedes virology, Alphavirus immunology, Alphavirus Infections transmission, Immunity, Innate genetics
Abstract

Mayaro (MAYV) is an emerging arthropod-borne virus belonging to the Alphavirus genus of the Togaviridae family. Although forest-dwelling Haemagogus mosquitoes have been considered as its main vector, the virus has also been detected in circulating Aedes ssp mosquitoes. Here we assess the susceptibility of Aedes aegypti and Aedes albopictus to infection with MAYV and their innate immune response at an early stage of infection. Aedes albopictus was more susceptible to infection with MAYV than Ae. aegypti. Analysis of transcript levels of twenty immunity-related genes by real-time PCR in the midgut of both mosquitoes infected with MAYV revealed increased expression of several immune genes, including CLIP-domain serine proteases, the anti-microbial peptides defensin A, E, cecropin E, and the virus inducible gene. The regulation of certain genes appeared to be Aedes species-dependent. Infection of Ae. aegypti with MAYV resulted in increased levels of myeloid differentiation2-related lipid recognition protein ( ML26A ) transcripts, as compared to Ae. albopictus . Increased expression levels of thio-ester-containing protein 22 ( TEP22 ) and Niemann-Pick type C1 ( NPC1 ) gene transcripts were observed in infected Ae. albopictus , but not Ae. aegypti . The differences in these gene expression levels during MAYV infection could explain the variation in susceptibility observed in both mosquito species., Competing Interests: The authors declare no conflict of interest.

Published
2019
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44. Molecular epidemiology of yellow fever in Bolivia from 1999 to 2008.

Author

Baronti C, Goitia NJ, Cook S, Roca Y, Revollo J, Flores JV, and de Lamballerie X

Subjects
Adult, Animals, Biological Evolution, Bolivia epidemiology, Female, Genetic Variation, Genotype, Humans, Male, Molecular Epidemiology, Phylogeny, Public Health, RNA, Viral genetics, Sequence Analysis, DNA, Viral Envelope Proteins genetics, Viral Proteins genetics, Yellow Fever transmission, Yellow Fever virology, Yellow fever virus isolation & purification, Young Adult, Aedes virology, Insect Vectors virology, Yellow Fever epidemiology, Yellow fever virus genetics
Abstract

Yellow fever (YF) is a serious public health problem in Bolivia since at least the 19th century. Surprisingly, very limited information has been made available to date regarding the genetic characterisation and epidemiology of Bolivian YF virus (YFV) strains. Here, we conducted the genetic characterization of 12 human isolates of YFV collected in Bolivia between 1999 and 2008, by sequencing and analysis of two regions of the viral genome: a fragment encoding structural proteins "PrM" (premembrane and envelope) and a distal region "EMF," spanning the end of the virus genome. Our study reveals a high genetic diversity of YFV strains circulating in Bolivia during the last decade: we identified not only "Peruvian-like" genotype II viruses (related to previously characterized Bolivian strains), but also, for the fist time, "Brazilian-like" genotype I viruses. During the complete period of the study, only cases of "jungle" YF were detected (i.e., circulation of YFV via a sylvatic cycle) with no cluster of urban cases. However, the very significant spread of the Aedes aegypti mosquito across Bolivian cities threatens the country with the reappearance of an urban YFV transmission cycle and thus is required a sustained epidemiological surveillance.

Published
2011
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45. Molecular epidemiological analysis of dengue fever in Bolivia from 1998 to 2008.

Author

Roca Y, Baronti C, Revollo RJ, Cook S, Loayza R, Ninove L, Fernandez RT, Flores JV, Herve JP, and de Lamballerie X

Subjects
Bolivia epidemiology, Dengue Virus classification, Dengue Virus genetics, Humans, Molecular Epidemiology, Phylogeny, Time Factors, Dengue epidemiology, Dengue virology
Abstract

Dengue fever was first recognized in Bolivia in 1931. However, very limited information was available to date regarding the genetic characterization and epidemiology of Bolivian dengue virus strains. Here, we performed genetic characterization of the full-length envelope gene of 64 Bolivian isolates from 1998 to 2008 and investigated their origin and evolution to determine whether strains circulated simultaneously or alternatively, and whether or not multiple introductions of distinct viral variants had occurred during the period studied. We determined that, during the last decade, closely related viruses circulated during several consecutive years (5, 6, and 6 years for DENV-1, DENV-2, and DENV-3, respectively) and the co-circulation of two or even three serotypes was observed. Emergence of new variants (distinct from those identified during the previous episodes) was identified in the case of DENV-1 (2007 outbreak) and DENV-2 (2001 outbreak). In all cases, it is likely that the viruses originated from neighboring countries.

Published
2009
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