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17 results on '"Baronia, Richa"'

9. In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines

Author

Singh,Manjri, Gupta,Parul, Baronia,Richa, Singh,Priti, Karuppiah,Stalin, Shanker,Rishi, Dwivedi,Premendra D, Singh,Surinder P, Singh,Manjri, Gupta,Parul, Baronia,Richa, Singh,Priti, Karuppiah,Stalin, Shanker,Rishi, Dwivedi,Premendra D, and Singh,Surinder P

Abstract

Manjri Singh,1 Parul Gupta,2 Richa Baronia,1 Priti Singh,1 Stalin Karuppiah,1 Rishi Shankar,3 Premendra D Dwivedi,2 Surinder P Singh1 1CSIR-National Physical Laboratory, New Delhi, 2CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO–DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO–DOx drug conjugate for head and neck cancer. Keywords: graphene oxide, doxorubicin, nanomedicine, head and neck cancer

Published
2018

10. Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy

Author

Baronia,Richa, Singh,Manjri, Gupta,Rajat B, Karuppiah,Stalin, Kumar,Rajiv, Belz,Jodi, Shanker,Rishi, Sridhar,Srinivas, Singh,Surinder P, Baronia,Richa, Singh,Manjri, Gupta,Rajat B, Karuppiah,Stalin, Kumar,Rajiv, Belz,Jodi, Shanker,Rishi, Sridhar,Srinivas, and Singh,Surinder P

Abstract

Richa Baronia,1 Manjri Singh,1 Rajat B Gupta,1 Stalin Karuppiah,1 Rajiv Kumar,2 Jodi Belz,2 Rishi Shanker,3 Srinivas Sridhar,2 Surinder P Singh1 1CSIR-National Physical Laboratory, Dr KS Krishnan Marg, New Delhi, India; 2Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, India Abstract: Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines. Keywords: gold nanoclusters, radiation therapy

Published
2018

15. Electro-oxidation of ethylene glycol on Pt[sbnd]Co metal synergy for direct ethylene glycol fuel cells: Reduced graphene oxide imparting a notable surface of action.

Author

Baronia, Richa, Goel, Jyoti, Baijnath, Kataria, Varsha, Basu, Suddhasatwa, and Singhal, Sunil K.

Subjects
*ELECTROLYTIC oxidation, *ETHYLENE glycol, *FUEL cells, *GRAPHENE oxide, *METALS, *BIMETALLIC catalysts
Abstract

Abstract Slow electro-oxidation reaction and low power output are two major limiting factors in successful commercialization of fuel cell technology. An efficient and stable electro-catalyst with effectual metal combination supported on a durable matrix may provide a viable solution to overcome these issues. The direct ethylene glycol fuel cell consisting of bimetallic anode catalysts are expected to lead out the high-power output issues. In the present paper, we emphasized on the synthesis of a high performing CO poisoning resistant Pt based binary anode catalysts for the electro-oxidation of ethylene glycol (EG) using a chemical reduction route. The electrocatalysts consists of Pt Co alloy nanoparticles with different composition of Pt and Co, supported on reduced graphene oxide (rGO). Physical characterizations revealed the formation of bi-metallic catalysts within the size ranges from 2 nm to 3 nm. Electrochemical analysis revealed that Pt x Co y /rGO electrocatalyst with x: y molar ratio of 1:9 imparts the highest peak current and power density as compared to commercially available Pt/C and Pt Co/C anode catalysts for ethylene glycol electro-oxidation. The power density (81.1 mW/cm2) obtained using Pt x Co y /rGO with x:y molar ratio of 1:9 metal catalyst in DEGFC is more than other synthesized catalysts at an operating temperature of 100 °C and the operating pressure of 1 bar with 2 M ethylene glycol as anode fuel and anode and cathode platinum metal loading of 2 mg/cm2. Graphical abstract Membrane electrode assembly of DEGFC illustrating electro-oxidation ethylene glycol at anode and cathode. Image 1 Highlights • Benefits of adding Co to Pt catalysts for ethylene glycol oxidation are emphasized. • Bi-metallic Pt Co/rGO catalyst was synthesized by chemical reduction method. • Pt Co (1:9)/rGO found to be catalytically active than commercial Pt/C and Pt Co/C. • PtCo(1:9)/rGO exhibited highest current density with lowest onset potential. • Peak power density of Pt Co (1:9)/rGO is 5 times higher than commercial catalysts. [ABSTRACT FROM AUTHOR]

Published
2019
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