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1. Signs and symptoms of COVID‐19 in patients with multiple sclerosis

Author

Schiavetti, Irene, Carmisciano, Luca, Ponzano, Marta, Cordioli, Cinzia, Cocco, Eleonora, Marfia, Girolama Alessandra, Inglese, Matilde, Filippi, Massimo, Radaelli, Marta, Bergamaschi, Roberto, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Confalonieri, Paolo, Perini, Paola, Trojano, Maria, Lanzillo, Roberta, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Group, MuSC‐19 Study, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri, Beatrice Maria Rossi, Alteno, Anastasia, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Morra, Vincenzo Brescia, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, d’Ambrosio, Alessandro, D’Amico, Emanuele, Danni, Maura Chiara, d’Arma, Alessia, Dattola, Vincenzo, de Biase, Stefano, De Luca, Giovanna, De Mercanti, Stefania Federica, De Mitri, Paolo, De Stefano, Nicola, Della Cava, Fabio Maria, Della Cava, Marco, and Di Lemme, Sonia

Subjects
Neurosciences, Multiple Sclerosis, Brain Disorders, Pain Research, Neurodegenerative, Good Health and Well Being, Humans, Aged, COVID-19, Ageusia, SARS-CoV-2, Anosmia, MuSC-19 Study Group, demyelinating diseases, disease-modifying treatment, multiple sclerosis, neurological disorders, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeClinical outcomes of multiple sclerosis (MS) patients affected by coronavirus disease 2019 (COVID-19) have been thoroughly investigated, but a further analysis on main signs and symptoms and their risk factors still needs attention. The objective of this study was to group together and describe based on similarity the most common signs and symptoms of COVID-19 in MS patients and identify all factors associated with their manifestation.MethodLogistic and linear regression models were run to recognize factors associated with each pooled group of symptoms and their total number.ResultsFrom March 2020 to November 2021, data were collected from 1354 MS patients with confirmed infection of COVID-19. Ageusia and anosmia was less frequent in older people (odds ratio [OR] 0.98; p = 0.005) and more in smoker patients (OR 1.39; p = 0.049). Smoke was also associated with an incremental number of symptoms (OR 1.24; p = 0.031), substance abuse (drugs or alcohol), conjunctivitis and rash (OR 5.20; p = 0.042) and the presence of at least one comorbidity with shortness of breath, tachycardia or chest pain (OR 1.24; p = 0.008). Some disease-modifying therapies were associated with greater frequencies of certain COVID-19 symptoms (association between anti-CD20 therapies and increment in the number of concomitant symptoms: OR 1.29; p = 0.05). Differences in frequencies between the three waves were found for flu-like symptoms (G1, p = 0.024), joint or muscle pain (G2, p = 0.013) and ageusia and anosmia (G5, p

Published
2022

2. The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

Author

Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Morra, Vincenzo Brescia, Pisoni, Enrico, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri, Rossi Beatrice Maria, Alteno, Anastasia, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Battaglia, Mario A, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Brescia, Morra Vincenzo, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, d'Ambrosio, Alessandro, and D'Amico, Emanuele

Subjects
Clinical Research, Neurosciences, Multiple Sclerosis, Brain Disorders, Autoimmune Disease, Neurodegenerative, Climate-Related Exposures and Conditions, Good Health and Well Being, Sustainable Cities and Communities, Air Pollution, COVID-19, Humans, Particulate Matter, SARS-CoV-2, MuSC-19 study group, air pollution, coronavirus, multiple sclerosis, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeSome studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m3 (PM2.5), may contribute to severe COVID-19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID-19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID-19 severity amongst PwMS.MethodsData were retrieved from an Italian web-based platform (MuSC-19) which includes PwMS with COVID-19. PM2.5 2016-2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID-19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID-19 severity.ResultsIn all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID-19 course (odds ratio 1.90; p = 0.009).ConclusionsEven if several other factors explain the unfavourable course of COVID-19 in PwMS, the role of air pollutants must be considered and further investigated.

Published
2022

3. Long-term follow-up (up to 11 years) of an Italian pediatric MS cohort treated with Natalizumab: a multicenter, observational study

Author

Baroncini, Damiano, Ghezzi, Angelo, Guaschino, Clara, Moiola, Lucia, Filippi, Massimo, Ianniello, Antonio, Pozzilli, Carlo, Lanzillo, Roberta, Brescia-Morra, Vincenzo, Margoni, Monica, Gallo, Paolo, Callari, Graziella, Grimaldi, Luigi, Lus, Giacomo, Calabrese, Massimiliano, Simone, Marta, Marfia, Girolama Alessandra, Rasia, Sarah, Cargnelutti, Daniela, Comi, Giancarlo, and Zaffaroni, Mauro

Published
2022
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4. MRI activity and extended interval of Natalizumab dosing regimen: a multicentre Italian study

Author

De Mercanti, Stefania Federica, Signori, Alessio, Cordioli, Cinzia, Signoriello, Elisabetta, Lus, Giacomo, Bonavita, Simona, Abbadessa, Gianmarco, Lavorgna, Luigi, Maniscalco, Giorgia Teresa, Curti, Erica, Lorefice, Lorena, Cocco, Eleonora, Nociti, Viviana, Mirabella, Massimiliano, Baroncini, Damiano, Mataluni, Giorgia, Landi, Doriana, Petruzzo, Martina, Lanzillo, Roberta, Gandoglia, Ilaria, Laroni, Alice, Frangiamore, Rita, Sartori, Arianna, Cavalla, Paola, Costantini, Gianfranco, Capra, Ruggero, Sormani, Maria Pia, and Clerico, Marinella

Published
2021
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5. Cell-based assays for the detection of MOG antibodies: a comparative study

Author

Gastaldi, Matteo, Scaranzin, Silvia, Jarius, Sven, Wildeman, Brigitte, Zardini, Elisabetta, Mallucci, Giulia, Rigoni, Eleonora, Vegezzi, Elisa, Foiadelli, Thomas, Savasta, Salvatore, Banfi, Paola, Versino, Maurizio, Benedetti, Luana, Novi, Giovanni, Mancardi, Margherita Maria, Giacomini, Thea, Annovazzi, Pietro, Baroncini, Damiano, Ferraro, Diana, Lampasona, Vito, Reindl, Markus, Waters, Patrick, and Franciotta, Diego

Published
2020
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6. Extending the Interval of Natalizumab Dosing: Is Efficacy Preserved?

Author

Clerico, Marinella, De Mercanti, Stefania Federica, Signori, Alessio, Iudicello, Marco, Cordioli, Cinzia, Signoriello, Elisabetta, Lus, Giacomo, Bonavita, Simona, Lavorgna, Luigi, Maniscalco, Giorgia Teresa, Curti, Erica, Lorefice, Lorena, Cocco, Eleonora, Nociti, Viviana, Mirabella, Massimiliano, Baroncini, Damiano, Mataluni, Giorgia, Landi, Doriana, Petruzzo, Martina, Lanzillo, Roberta, Gandoglia, Ilaria, Laroni, Alice, Frangiamore, Rita, Sartori, Arianna, Cavalla, Paola, Costantini, Gianfranco, Sormani, Maria Pia, and Capra, Ruggero

Published
2020
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7. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Author

Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri Rossi, Beatrice Maria, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, dʼAmbrosio, Alessandro, DʼAmico, Emanuele, Danni, Maura Chiara, dʼArma, Alessia, Dattola, Vincenzo, de Biase, Stefano, Luca, Giovanna De, Mercanti, Stefania Federica De, De Mitri, Paolo, De Stefano, Nicola, Cava, Marco Della, Napoli, Mario di, Sapio, Alessia Di, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Ferrò, Maria Teresa, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grasso, Maria Grazia, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Infante, Maria Teresa, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, LʼEpiscopo, Maria Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Mancinelli, Chiara Rosa, Mancinelli, Luca, Manganotti, Paolo, Maniscalco, Giorgia Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Boneschi, Filippo Martinelli, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, MontiBragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Nicoletti, Carolina Gabri, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, Pietroboni, Anna M, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Rilla, Maria Teresa, Rinaldi, Francesca, Romano, Calogero Marcello, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scarano, Giuditta Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Stromillo, Maria Laura, Strumia, Silvia, Susani, Emanuela Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Torri, Clerici Valentina, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Verrengia, Elena Pinuccia, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Zarbo, Ignazio Roberto, and Zuliani, Luigi

Published
2022
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9. Cladribine vs other drugs in MS: Merging randomized trial with real-life data

Author

Signori, Alessio, Saccà, Francesco, Lanzillo, Roberta, Maniscalco, Giorgia Teresa, Signoriello, Elisabetta, Repice, Anna Maria, Annovazzi, Pietro, Baroncini, Damiano, Clerico, Marinella, Binello, Eleonora, Cerqua, Raffaella, Mataluni, Giorgia, Perini, Paola, Bonavita, Simona, Lavorgna, Luigi, Zarbo, Ignazio Roberto, Laroni, Alice, Pareja-Gutierrez, Lorena, La Gioia, Sara, Frigeni, Barbara, Barcella, Valeria, Frau, Jessica, Cocco, Eleonora, Fenu, Giuseppe, Clerici, Valentina Torri, Sartori, Arianna, Rasia, Sarah, Cordioli, Cinzia, Stromillo, Maria Laura, Di Sapio, Alessia, Pontecorvo, Simona, Grasso, Roberta, Barone, Stefania, Barrilà, Caterina, Russo, Cinzia Valeria, Esposito, Sabrina, Ippolito, Domenico, Landi, Doriana, Visconti, Andrea, and Sormani, Maria Pia

Published
2020
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14. Towards a validated definition of the clinical transition to secondary progressive multiple sclerosis: A study from the Italian MS Register

Author

Iaffaldano, Pietro, primary, Lucisano, Giuseppe, additional, Guerra, Tommaso, additional, Patti, Francesco, additional, Onofrj, Marco, additional, Brescia Morra, Vincenzo, additional, Zaffaroni, Mauro, additional, Pozzilli, Carlo, additional, Cocco, Eleonora, additional, Sola, Patrizia, additional, Salemi, Giuseppe, additional, Inglese, Matilde, additional, Bergamaschi, Roberto, additional, Gasperini, Claudio, additional, Conte, Antonella, additional, Salvetti, Marco, additional, Lus, Giacomo, additional, Maniscalco, Giorgia Teresa, additional, Totaro, Rocco, additional, Vianello, Marika, additional, Granella, Franco, additional, Ferraro, Elisabetta, additional, Aguglia, Umberto, additional, Gatto, Maurizia, additional, Sangalli, Francesca, additional, Chisari, Clara Grazia, additional, De Luca, Giovanna, additional, Carotenuto, Antonio, additional, Baroncini, Damiano, additional, Colombo, Delia, additional, Nica, Mihaela, additional, Paolicelli, Damiano, additional, Comi, Giancarlo, additional, Filippi, Massimo, additional, Amato, Maria Pia, additional, and Trojano, Maria, additional

Published
2022
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15. Assessing association of comorbidities with treatment choice and persistence in MS: A real-life multicenter study

Author

Laroni, Alice, Signori, Alessio, Maniscalco, Giorgia T., Lanzillo, Roberta, Russo, Cinzia Valeria, Binello, Eleonora, Lo Fermo, Salvatore, Repice, Annamaria, Annovazzi, Pietro, Bonavita, Simona, Clerico, Marinella, Baroncini, Damiano, Prosperini, Luca, La Gioia, Sara, Rossi, Silvia, Cocco, Eleonora, Frau, Jessica, Torri Clerici, Valentina, Signoriello, Elisabetta, Sartori, Arianna, Zarbo, Ignazio Roberto, Rasia, Sarah, Cordioli, Cinzia, Cerqua, Raffaella, Di Sapio, Alessia, Lavorgna, Luigi, Pontecorvo, Simona, Barrilà, Caterina, Saccà, Francesco, Frigeni, Barbara, Esposito, Sabrina, Ippolito, Domenico, Gallo, Fabio, and Sormani, Maria Pia

Published
2017
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16. Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEQ-IT)

Author

Pilotto, Silvy, Gencarelli, Jessica, Bova, Stefania Maria, Gerosa, Leonardo, Baroncini, Damiano, Olivotto, Sara, Alfei, Enrico, Zaffaroni, Mauro, Suppiej, Agnese, Cocco, Eleonora, Trojano, Maria, Amato, Maria Pia, D'Alfonso, Sandra, Boneschi, Filippo Martinelli, Waubant, Emmanuelle, Ghezzi, Angelo, Bergamaschi, Roberto, and Pugliatti, Maura

Published
2021
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17. A real‐world study of alemtuzumab in a cohort of Italian patients

Author

Russo, Cinzia Valeria, primary, Saccà, Francesco, additional, Frau, Jessica, additional, Annovazzi, Pietro, additional, Signoriello, Elisabetta, additional, Bonavita, Simona, additional, Grasso, Roberta, additional, Clerico, Marinella, additional, Cordioli, Cinzia, additional, Laroni, Alice, additional, Capobianco, Marco, additional, Torri Clerici, Valentina, additional, Sartori, Arianna, additional, Cavalla, Paola, additional, Maniscalco, Giorgia Teresa, additional, La Gioia, Sara, additional, Caleri, Francesca, additional, Giugno, Alessia, additional, Iodice, Rosa, additional, Carotenuto, Antonio, additional, Cocco, Eleonora, additional, Fenu, Giuseppe, additional, Zaffaroni, Mauro, additional, Baroncini, Damiano, additional, Lus, Giacomo, additional, Gallo, Antonio, additional, De Mercanti, Stefania Federica, additional, Lapucci, Caterina, additional, Di Francescantonio, Valeria, additional, Brambilla, Laura, additional, Sormani, Maria Pia, additional, and Signori, Alessio, additional

Published
2021
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18. Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire)

Author

Pilotto, Silvy, primary, Gencarelli, Jessica, additional, Bova, Stefania, additional, Gerosa, Leonardo, additional, Baroncini, Damiano, additional, Olivotto, Sara, additional, Alfei, Enrico, additional, Zaffaroni, Mauro, additional, Suppiej, Agnese, additional, Cocco, Eleonora, additional, Trojano, Maria, additional, Amato, Maria Pia, additional, D'Alfonso, Sandra, additional, Martinelli-Boneschi, Filippo, additional, Waubant, Emmanuelle, additional, Ghezzi, Angelo, additional, Bergamaschi, Roberto, additional, and Pugliatti, Maura, additional

Published
2021
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19. Fingolimod versus interferon beta/glatiramer acetate after natalizumab suspension in multiple sclerosis

Author

Iaffaldano, Pietro, Lucisano, Giuseppe, Pozzilli, Carlo, Brescia Morra, Vincenzo, Ghezzi, Angelo, Millefiorini, Enrico, Patti, Francesco, Lugaresi, Alessandra, Zimatore, Giovanni Bosco, Marrosu, Maria Giovanna, Amato, Maria Pia, Bertolotto, Antonio, Bergamaschi, Roberto, Granella, Franco, Coniglio, Gabriella, Tedeschi, Gioacchino, Sola, Patrizia, Lus, Giacomo, Ferrò, Maria Teresa, Iuliano, Gerardo, Corea, Francesco, Protti, Alessandra, Cavalla, Paola, Guareschi, Angelica, Rodegher, Mariaemma, Paolicelli, Damiano, Tortorella, Carla, Lepore, Vito, Prosperini, Luca, Saccà, Francesco, Baroncini, Damiano, Comi, Giancarlo, and Trojano, Maria

Published
2015
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20. SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study

Author

Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Landi, Doriana, additional, Carmisciano, Luca, additional, De Rossi, Nicola, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, Brescia Morra, Vincenzo, additional, Trojano, Maria, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, Fragoso, Yara Dadalti, additional, Sen, Sedat, additional, Siva, Aksel, additional, Furlan, Roberto, additional, Salvetti, Marco, additional, Abbadessa, Gianmarco, additional, Aguglia, Umberto, additional, Allegorico, Lia, additional, Allegri, Rossi Beatrice Maria, additional, Amato, Maria Pia, additional, Annovazzi, Pietro, additional, Antozzi, Carlo, additional, Appendino, Lucia, additional, Arena, Sebastiano, additional, Baione, Viola, additional, Balgera, Roberto, additional, Barcella, Valeria, additional, Baroncini, Damiano, additional, Barrilà, Caterina, additional, Battaglia, Mario A., additional, Bellacosa, Alessandra, additional, Bellucci, Gianmarco, additional, Bergamaschi, Roberto, additional, Bergamaschi, Valeria, additional, Bezzini, Daiana, additional, Biolzi, Beatrice, additional, Bisecco, Alvino, additional, Bonavita, Simona, additional, Borriello, Giovanna, additional, Bosa, Chiara, additional, Bosco, Antonio, additional, Bovis, Francesca, additional, Bozzali, Marco, additional, Brambilla, Laura, additional, Brescia, Morra Vincenzo, additional, Brichetto, Giampaolo, additional, Buccafusca, Maria, additional, Bucciantini, Elisabetta, additional, Bucello, Sebastiano, additional, Buscarinu, Maria Chiara, additional, Cabboi, Maria Paola, additional, Calabrese, Massimiliano, additional, Calabria, Francesca, additional, Caleri, Francesca, additional, Camilli, Federico, additional, Caniatti, Luisa Maria, additional, Cantello, Roberto, additional, Capra, Ruggero, additional, Capuano, Rocco, additional, Carta, Patrizia, additional, Cavalla, Paola, additional, Celani, Maria Grazia, additional, Cellerino, Maria, additional, Cerqua, Raffaella, additional, Chisari, Clara, additional, Clerici, Raffaella, additional, Clerico, Marinella, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Confalonieri, Paolo, additional, Conte, Antonella, additional, Conti, Marta Zaffira, additional, Cordano, Christian, additional, Cordera, Susanna, additional, Corea, Francesco, additional, Correale, Claudio, additional, Cottone, Salvatore, additional, Crescenzo, Francesco, additional, Curti, Erica, additional, d’Ambrosio, Alessandro, additional, D’Amico, Emanuele, additional, Danni, Maura Chiara, additional, d’Arma, Alessia, additional, Dattola, Vincenzo, additional, de Biase, Stefano, additional, De Luca, Giovanna, additional, De Mercanti, Stefania Federica, additional, De Mitri, Paolo, additional, De Stefano, Nicola, additional, Della Cava, Marco, additional, di Napoli, Mario, additional, Di Sapio, Alessia, additional, Docimo, Renato, additional, Dutto, Anna, additional, Evangelista, Luana, additional, Fanara, Salvatore, additional, Ferraro, Diana, additional, Ferrò, Maria Teresa, additional, Filippi, Massimo, additional, Fioretti, Cristina, additional, Fratta, Mario, additional, Frau, Jessica, additional, Fronza, Marzia, additional, Gajofatto, Alberto, additional, Gallo, Antonio, additional, Gallo, Paolo, additional, Gasperini, Claudio, additional, Ghazaryan, Anna, additional, Giometto, Bruno, additional, Gobbin, Francesca, additional, Govone, Flora, additional, Granella, Franco, additional, Grange, Erica, additional, Grasso, Maria Grazia, additional, Guareschi, Angelica, additional, Guaschino, Clara, additional, Guerrieri, Simone, additional, Guidetti, Donata, additional, Iaffaldano, Pietro, additional, Ianniello, Antonio, additional, Iasevoli, Luigi, additional, Imperiale, Daniele, additional, Infante, Maria Teresa, additional, Inglese, Matilde, additional, Iodice, Rosa, additional, Iovino, Aniello, additional, Konrad, Giovanna, additional, Lanzillo, Roberta, additional, Lapucci, Caterina, additional, Lavorgna, Luigi, additional, L’Episcopo Maria, Rita, additional, Leva, Serena, additional, Liberatore, Giuseppe, additional, Lo Re, Marianna, additional, Longoni, Marco, additional, Lopiano, Leonardo, additional, Lorefice, Lorena, additional, Lucchini, Matteo, additional, Lus, Giacomo, additional, Maimone, Davide, additional, Malentacchi, Maria, additional, Mallucci, Giulia, additional, Malucchi, Simona, additional, Mancinelli, Chiara Rosa, additional, Mancinelli, Luca, additional, Manganotti, Paolo, additional, Maniscalco, Teresa Giorgia, additional, Mantero, Vittorio, additional, Marangoni, Sabrina, additional, Marastoni, Damiano, additional, Marfia, Alessandra Girolama, additional, Marinelli, Fabiana, additional, Marti, Alessandro, additional, Martinelli Boneschi, Filippo, additional, Masserano Zoli, Federco, additional, Matta, Francesca, additional, Mendozzi, Laura, additional, Meucci, Giuseppe, additional, Miante, Silvia, additional, Miele, Giuseppina, additional, Milano, Eva, additional, Mirabella, Massimiliano, additional, Missione, Rosanna, additional, Moccia, Marcello, additional, Montepietra, Sara, additional, Monti Bragadin, Margherita, additional, Montini, Federico, additional, Motta, Roberta, additional, Nardone, Raffaele, additional, Nicoletti, Carolina Gabri, additional, Nobile-Orazio, Eduardo, additional, Nozzolillo, Agostino, additional, Onofrj, Marco, additional, Orlandi, Riccardo, additional, Palmieri, Anna, additional, Paolicelli, Damiano, additional, Pasquali, Livia, additional, Pastò, Luisa, additional, Pedrazzoli, Elisabetta, additional, Perini, Paola, additional, Pesci, Ilaria, additional, Petracca, Maria, additional, Petrone, Alfredo, additional, Piantadosi, Carlo, additional, Pietroboni, Anna M., additional, Pinardi, Federica, additional, Ponzano, Marta, additional, Portaccio, Emilio, additional, Pozzato, Mattia, additional, Pozzilli, Carlo, additional, Prosperini, Luca, additional, Protti, Alessandra, additional, Ragonese, Paolo, additional, Rasia, Sarah, additional, Realmuto, Sabrina, additional, Repice, Anna, additional, Rigoni, Eleonora, additional, Rilla, Maria Teresa, additional, Rinaldi, Francesca, additional, Romano, Calogero Marcello, additional, Ronzoni, Marco, additional, Rovaris, Marco, additional, Ruscica, Francesca, additional, Sabattini, Loredana, additional, Salemi, Giuseppe, additional, Saraceno, Lorenzo, additional, Sartori, Alessia, additional, Sartori, Arianna, additional, Sbragia, Elvira, additional, Scandellari, Cinzia, additional, Scarano Giuditta, Ilaria, additional, Scarano, Valentina, additional, Schillaci, Valentina, additional, Sessa, Maria, additional, Sgarito, Caterina, additional, Sibilia, Grazia, additional, Siciliano, Gabriele, additional, Signori, Alessio, additional, Signoriello, Elisabetta, additional, Sinisi, Leonardo, additional, Sireci, Francesca, additional, Sola, Patrizia, additional, Solaro, Claudio, additional, Sormani, Maria Pia, additional, Sotgiu, Stefano, additional, Sparaco, Maddalena, additional, Stromillo, Maria Laura, additional, Strumia, Silvia, additional, Susani, Laura Emanuela, additional, Tabiadon, Giulietta, additional, Teatini, Francesco, additional, Tomassini, Valentina, additional, Tonietti, Simone, additional, Torri, Clerici Valentina, additional, Tortorella, Carla, additional, Toscano, Simona, additional, Totaro, Rocco, additional, Trotta, Maria, additional, Turano, Gabriella, additional, Ulivelli, Monica, additional, Valentino, Manzo, additional, Vaula, Giovanna, additional, Vecchio, Domizia, additional, Vercellino, Marco, additional, Verrengia, Elena Pinuccia, additional, Vianello, Marika, additional, Virgilio, Eleonora, additional, Vitetta, Francesca, additional, Vollaro, Stefano, additional, Zaffaroni, Mauro, additional, Zampolini, Mauro, additional, Zarbo, Ignazio Roberto, additional, Zito, Antonio, additional, and Zuliani, Luigi, additional

Published
2021
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21. sj-docx-1-mso-10.1177_20552173211059048 - Supplemental material for Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire)

Author

Pilotto, Silvy, Gencarelli, Jessica, Bova, Stefania, Gerosa, Leonardo, Baroncini, Damiano, Olivotto, Sara, Alfei, Enrico, Zaffaroni, Mauro, Suppiej, Agnese, Cocco, Eleonora, Trojano, Maria, Amato, Maria Pia, D'Alfonso, Sandra, Martinelli-Boneschi, Filippo, Waubant, Emmanuelle, Ghezzi, Angelo, Bergamaschi, Roberto, and Pugliatti, Maura

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-mso-10.1177_20552173211059048 for Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire) by Silvy Pilotto, Jessica Gencarelli, Stefania Bova, Leonardo Gerosa, Damiano Baroncini, Sara Olivotto, Enrico Alfei, Mauro Zaffaroni, Agnese Suppiej, Eleonora Cocco, Maria Trojano, Maria Pia Amato, Sandra D'Alfonso and Filippo Martinelli-Boneschi, Emmanuelle Waubant, Angelo Ghezzi, Roberto Bergamaschi, Maura Pugliatti in Multiple Sclerosis Journal ��� Experimental, Translational and Clinical

Published
2021
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22. sj-docx-2-mso-10.1177_20552173211059048 - Supplemental material for Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire)

Author

Pilotto, Silvy, Gencarelli, Jessica, Bova, Stefania, Gerosa, Leonardo, Baroncini, Damiano, Olivotto, Sara, Alfei, Enrico, Zaffaroni, Mauro, Suppiej, Agnese, Cocco, Eleonora, Trojano, Maria, Amato, Maria Pia, D'Alfonso, Sandra, Martinelli-Boneschi, Filippo, Waubant, Emmanuelle, Ghezzi, Angelo, Bergamaschi, Roberto, and Pugliatti, Maura

Subjects
FOS: Clinical medicine, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-2-mso-10.1177_20552173211059048 for Etiological research in pediatric multiple sclerosis: A tool to assess environmental exposures (PEDiatric Italian Genetic and enviRonment ExposurE Questionnaire) by Silvy Pilotto, Jessica Gencarelli, Stefania Bova, Leonardo Gerosa, Damiano Baroncini, Sara Olivotto, Enrico Alfei, Mauro Zaffaroni, Agnese Suppiej, Eleonora Cocco, Maria Trojano, Maria Pia Amato, Sandra D'Alfonso and Filippo Martinelli-Boneschi, Emmanuelle Waubant, Angelo Ghezzi, Roberto Bergamaschi, Maura Pugliatti in Multiple Sclerosis Journal ��� Experimental, Translational and Clinical

Published
2021
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23. Risk of Persistent Disability in Patients With Pediatric-Onset Multiple Sclerosis

Author

Baroncini, Damiano, Simone, Marta, Iaffaldano, Pietro, Brescia Morra, Vincenzo, Lanzillo, Roberta, Filippi, Massimo, Romeo, Marzia, Patti, Francesco, Chisari, Clara Grazia, Cocco, Eleonora, Fenu, Giuseppe, Salemi, Giuseppe, Ragonese, Paolo, Inglese, Matilde, Cellerino, Maria, Margari, Lucia, Comi, Giancarlo, Zaffaroni, Mauro, Ghezzi, Angelo, Mirabella, Massimiliano, Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Baroncini, Damiano, Simone, Marta, Iaffaldano, Pietro, Brescia Morra, Vincenzo, Lanzillo, Roberta, Filippi, Massimo, Romeo, Marzia, Patti, Francesco, Chisari, Clara Grazia, Cocco, Eleonora, Fenu, Giuseppe, Salemi, Giuseppe, Ragonese, Paolo, Inglese, Matilde, Cellerino, Maria, Margari, Lucia, Comi, Giancarlo, Zaffaroni, Mauro, Ghezzi, Angelo, Mirabella, Massimiliano, and Mirabella, Massimiliano (ORCID:0000-0002-7783-114X)

Abstract

Importance: Availability of new disease-modifying therapies (DMTs) and changes of therapeutic paradigms have led to a general improvement of multiple sclerosis (MS) prognosis in adults. It is still unclear whether this improvement also involves patients with pediatric-onset MS (POMS), whose early management is more challenging. Objective: To evaluate changes in the prognosis of POMS over time in association with changes in therapeutic and managing standards. Design, setting, and participants: Retrospective, multicenter, observational study. Data were extracted and collected in May 2019 from the Italian MS Registry, a digital database including more than 59 000 patients. Inclusion criteria were MS onset before age 18 years, diagnosis before January 2014, and disease duration of at least 3 years. Exclusion criteria were primary progressive MS, Expanded Disability Status Scale (EDSS) score of at least 8 one year after onset, unavailability of diagnosis date, and less than 2 EDSS score evaluations. Eligible patients were 4704 patients with POMS. According to these criteria, we enrolled 3198 patients, excluding 1506. Exposures: We compared time to reach disability milestones by epoch of MS diagnosis (<1993, 1993-1999, 2000-2006, and 2007-2013), adjusting for possible confounders linked to EDSS evaluations and clinical disease activity. We then analyzed the difference among the 4 diagnosis epochs regarding demographic characteristics, clinical disease activity at onset, and DMTs management. Main outcomes and measures: Disability milestones were EDSS score 4.0 and 6.0, confirmed in the following clinical evaluation and in the last available visit. Results: We enrolled 3198 patients with POMS (mean age at onset, 15.2 years; 69% female; median time to diagnosis, 3.2 years; annualized relapse rate in first 1 and 3 years, 1.3 and 0.6, respectively), with a mean (SD) follow-up of 21.8 (11.7) years. Median survival times to reach EDSS score of 4.0 and 6.0 were 31.7 and 40.5 y

Published
2021

24. Switch from sequestering to anti-CD20 depleting treatment: disease activity outcomes during wash-out and in the first 6 months of ocrelizumab therapy

Author

Signoriello, Elisabetta, primary, Lus, Giacomo, additional, Bonavita, Simona, additional, Lanzillo, Roberta, additional, Saccà, Francesco, additional, Landi, Doriana, additional, Frau, Jessica, additional, Baroncini, Damiano, additional, Zaffaroni, Mauro, additional, Maniscalco, Giorgia Teresa, additional, Curti, Erica, additional, Sartori, Arianna, additional, Cepparulo, Simone, additional, Marfia, Girolama Alessandra, additional, Nicoletti, Carolina Gabri, additional, Carotenuto, Antonio, additional, Nociti, Viviana, additional, Caleri, Francesca, additional, Sormani, Maria Pia, additional, and Signori, Alessio, additional

Published
2021
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26. First therapy choice in newly diagnosed Multiple Sclerosis patients: A multicenter Italian study

Author

Maniscalco, Giorgia T., primary, Saccà, Francesco, additional, Lanzillo, Roberta, additional, Annovazzi, Pietro, additional, Baroncini, Damiano, additional, Binello, Eleonora, additional, Repice, Annamaria, additional, Perini, Paola, additional, Clerico, Marinella, additional, Mataluni, Giorgia, additional, Bonavita, Simona, additional, La Gioia, Sara, additional, Gutierrez, Lorena Pareja, additional, Laroni, Alice, additional, Frau, Jessica, additional, Cocco, Eleonora, additional, Torri Clerici, Valentina, additional, Zarbo, Ignazio Roberto, additional, Sartori, Arianna, additional, Signoriello, Elisabetta, additional, Rasia, Sarah, additional, Cordioli, Cinzia, additional, Stromillo, Maria Laura, additional, Cerqua, Raffaella, additional, Pontecorvo, Simona, additional, Di Sapio, Alessia, additional, Grasso, Roberta, additional, Barone, Stefania, additional, Lavorgna, Luigi, additional, Barrilà, Caterina, additional, Landi, Doriana, additional, Russo, Cinzia Valeria, additional, Frigeni, Barbara, additional, Ippolito, Domenico, additional, Turano, Gabriella, additional, Carmisciano, Luca, additional, Sormani, Maria Pia, additional, and Signori, Alessio, additional

Published
2020
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28. Changes in Management of Pediatric-onset Multiple Sclerosis: Are We Really Modifying the Disease Course? Data from the Italian MS Registry (3938)

Author

Baroncini, Damiano, primary, Iaffaldano, Pietro, additional, Simone, Marta, additional, Morra, Vincenzo Brescia, additional, Filippi, Massimo, additional, Romeo, Marzia, additional, Patti, Francesco, additional, Chisari, Clara Grazia, additional, Cocco, Eleonora, additional, Fenu, Giuseppe, additional, Salemi, Giuseppe, additional, Ragonese, Paolo, additional, Inglese, Matilde, additional, Cellerino, Maria, additional, Comi, Giancarlo, additional, Zaffaroni, Mauro, additional, and Ghezzi, Angelo, additional

Published
2020
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29. Switch from sequestering to anti-CD20 depleting treatment: disease activity outcomes during wash-out and in the first 6 months of ocrelizumab therapy.

Author

Signoriello, Elisabetta, Lus, Giacomo, Bonavita, Simona, Lanzillo, Roberta, Saccà, Francesco, Landi, Doriana, Frau, Jessica, Baroncini, Damiano, Zaffaroni, Mauro, Maniscalco, Giorgia Teresa, Curti, Erica, Sartori, Arianna, Cepparulo, Simone, Marfia, Girolama Alessandra, Nicoletti, Carolina Gabri, Carotenuto, Antonio, Nociti, Viviana, Caleri, Francesca, Sormani, Maria Pia, and Signori, Alessio

Subjects
THERAPEUTICS, MAGNETIC resonance imaging, LYMPHOCYTE count, DISEASE relapse, MULTIPLE sclerosis
Abstract

Objectives: Switching between treatments is an opportunity for patients with multiple sclerosis (MS) to ameliorate disease control or safety. The aim of this study was to investigate the impact of switching from fingolimod (FTY) or natalizumab (NTZ) to ocrelizumab (OCR) on disease activity. Methods: We retrospectively enrolled 165 patients treated with OCR from 11 MS centres. We assessed the association of demographic and clinical characteristics on relapse rate (RR) and activity on magnetic resonance imaging (MRI) during wash-out and after 6 months of treatment with OCR through univariable and multivariable negative binomial regression models. Results: We registered a total of 35 relapses during the wash-out period. Previous treatment with FTY, relapses in the previous year, and relapsing-remitting course were associated with higher RR. In the first 6 months of OCR, 12 patients had clinical or MRI disease activity. Higher Expanded Disability Status Scale (EDSS) and higher lymphocyte count at OCR start were associated with a reduced probability of relapse. Discussion and Conclusion: This study confirms that withdrawal from sequestering agents as FTY increases the risk of relapses in the wash-out period. Nevertheless, starting OCR before achieving complete immune reconstitution could limit its effectiveness in the first 6 months probably because trapped lymphocytes escape the CD20-mediated depletion. [ABSTRACT FROM AUTHOR]

Published
2022
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30. MSJ790390_supplementary_material – Supplemental material for Determinants of therapy switch in multiple sclerosis treatment-naïve patients: A real-life study

Author

Saccà, Francesco, Lanzillo, Roberta, Signori, Alessio, Maniscalco, Giorgia T, Signoriello, Elisabetta, Fermo, Salvatore Lo, Repice, Annamaria, Annovazzi, Pietro, Baroncini, Damiano, Clerico, Marinella, Binello, Eleonora, Cerqua, Raffaella, Mataluni, Giorgia, Bonavita, Simona, Lavorgna, Luigi, Zarbo, Ignazio Roberto, Laroni, Alice, Rossi, Silvia, Gutierrez, Lorena Pareja, Gioia, Sara La, Frigeni, Barbara, Barcella, Valeria, Frau, Jessica, Cocco, Eleonora, Fenu, Giuseppe, Clerici, Valentina Torri, Sartori, Arianna, Rasia, Sarah, Cordioli, Cinzia, Sapio, Alessia Di, Pontecorvo, Simona, Grasso, Roberta, Barrilà, Caterina, Russo, Cinzia Valeria, Esposito, Sabrina, Ippolito, Domenico, Bovis, Francesca, Gallo, Fabio, and Sormani, Maria Pia

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, MSJ790390_supplementary_material for Determinants of therapy switch in multiple sclerosis treatment-naïve patients: A real-life study by Francesco Saccà, Roberta Lanzillo, Alessio Signori, Giorgia T Maniscalco, Elisabetta Signoriello, Salvatore Lo Fermo, Annamaria Repice, Pietro Annovazzi, Damiano Baroncini, Marinella Clerico, Eleonora Binello, Raffaella Cerqua, Giorgia Mataluni, Simona Bonavita, Luigi Lavorgna, Ignazio Roberto Zarbo, Alice Laroni, Silvia Rossi, Lorena Pareja Gutierrez, Sara La Gioia, Barbara Frigeni, Valeria Barcella, Jessica Frau, Eleonora Cocco, Giuseppe Fenu, Valentina Torri Clerici, Arianna Sartori, Sarah Rasia, Cinzia Cordioli, Alessia Di Sapio, Simona Pontecorvo, Roberta Grasso, Caterina Barrilà, Cinzia Valeria Russo, Sabrina Esposito, Domenico Ippolito, Francesca Bovis, Fabio Gallo and Maria Pia Sormani in Multiple Sclerosis Journal

Published
2018
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31. Impact of natural menopause on multiple sclerosis: a multicentre study

Author

Baroncini, Damiano, primary, Annovazzi, Pietro Osvaldo, additional, De Rossi, Nicola, additional, Mallucci, Giulia, additional, Torri Clerici, Valentina, additional, Tonietti, Simone, additional, Mantero, Vittorio, additional, Ferrò, Maria Teresa, additional, Messina, Maria Josè, additional, Barcella, Valeria, additional, La Mantia, Loredana, additional, Ronzoni, Marco, additional, Barrilà, Caterina, additional, Clerici, Raffaella, additional, Susani, Emanuela Laura, additional, Fusco, Maria Letizia, additional, Chiveri, Luca, additional, Abate, Lucia, additional, Ferraro, Ottavia, additional, Capra, Ruggero, additional, Colombo, Elena, additional, Confalonieri, Paolo, additional, and Zaffaroni, Mauro, additional

Published
2019
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34. Determinants of therapy switch in multiple sclerosis treatment-naïve patients: A real-life study

Author

Saccà, Francesco, primary, Lanzillo, Roberta, additional, Signori, Alessio, additional, Maniscalco, Giorgia T, additional, Signoriello, Elisabetta, additional, Lo Fermo, Salvatore, additional, Repice, Annamaria, additional, Annovazzi, Pietro, additional, Baroncini, Damiano, additional, Clerico, Marinella, additional, Binello, Eleonora, additional, Cerqua, Raffaella, additional, Mataluni, Giorgia, additional, Bonavita, Simona, additional, Lavorgna, Luigi, additional, Zarbo, Ignazio Roberto, additional, Laroni, Alice, additional, Rossi, Silvia, additional, Pareja Gutierrez, Lorena, additional, La Gioia, Sara, additional, Frigeni, Barbara, additional, Barcella, Valeria, additional, Frau, Jessica, additional, Cocco, Eleonora, additional, Fenu, Giuseppe, additional, Torri Clerici, Valentina, additional, Sartori, Arianna, additional, Rasia, Sarah, additional, Cordioli, Cinzia, additional, Di Sapio, Alessia, additional, Pontecorvo, Simona, additional, Grasso, Roberta, additional, Barrilà, Caterina, additional, Russo, Cinzia Valeria, additional, Esposito, Sabrina, additional, Ippolito, Domenico, additional, Bovis, Francesca, additional, Gallo, Fabio, additional, and Sormani, Maria Pia, additional

Published
2018
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35. A Real-Life Study of Alemtuzumab: Impact of Previous Therapies and Washout Period on Disease Activity (P6.349)

Author

Sacca, Francesco, primary, Sormani, Maria Pia, additional, Signori, Alessio, additional, Lanzillo, Roberta, additional, Baroncini, Damiano, additional, Annovazzi, Pietro, additional, Signoriello, Elisabetta, additional, Laroni, Alice, additional, Capobianco, Marco, additional, Sartori, Arianna, additional, La Gioia, Sara, additional, Maniscalco, Giorgia Teresa, additional, Cordioli, Cinzia, additional, Rasia, Sarah, additional, Clerico, Marinella, additional, Fenu, Giuseppe, additional, Cocco, Eleonora, additional, and Frau, Jessica, additional

Published
2018
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36. Long-term follow-up of pediatric MS patients starting treatment with injectable first-line agents: A multicentre, Italian, retrospective, observational study

Author

Baroncini, Damiano, primary, Zaffaroni, Mauro, additional, Moiola, Lucia, additional, Lorefice, Lorena, additional, Fenu, Giuseppe, additional, Iaffaldano, Pietro, additional, Simone, Marta, additional, Fanelli, Fulvia, additional, Patti, Francesco, additional, D’Amico, Emanuele, additional, Capobianco, Marco, additional, Bertolotto, Antonio, additional, Gallo, Paolo, additional, Margoni, Monica, additional, Miante, Silvia, additional, Milani, Nicoletta, additional, Amato, Maria Pia, additional, Righini, Isabella, additional, Bellantonio, Paolo, additional, Scandellari, Cinzia, additional, Costantino, Gianfranco, additional, Scarpini, Elio, additional, Bergamaschi, Roberto, additional, Mallucci, Giulia, additional, Comi, Giancarlo, additional, and Ghezzi, Angelo, additional

Published
2018
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40. Dataset of mRNA levels for dopaminergic receptors, adrenoceptors and tyrosine hydroxylase in lymphocytes from subjects with clinically isolated syndromes

Author

Cosentino, Marco, primary, Zaffaroni, Mauro, additional, Legnaro, Massimiliano, additional, Bombelli, Raffaella, additional, Schembri, Laura, additional, Baroncini, Damiano, additional, Bianchi, Anna, additional, Clerici, Raffaella, additional, Guidotti, Mario, additional, Banfi, Paola, additional, Bono, Giorgio, additional, and Marino, Franca, additional

Published
2016
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41. Outcomes after fingolimod to alemtuzumab treatment shift in relapsing–remitting MS patients: a multicentre cohort study.

Author

Frau, Jessica, Saccà, Francesco, Signori, Alessio, Baroncini, Damiano, Fenu, Giuseppe, Annovazzi, Pietro, Capobianco, Marco, Signoriello, Elisabetta, Laroni, Alice, La Gioia, Sara, Sartori, Arianna, Maniscalco, Giorgia Teresa, Bonavita, Simona, Clerico, Marinella, Russo, Cinzia Valeria, Gallo, Antonio, Lapucci, Caterina, Carotenuto, Antonio, Sormani, Maria Pia, and Cocco, Eleonora

Subjects
LYMPHOCYTE count, ALEMTUZUMAB, COHORT analysis, MAGNETIC resonance imaging, DISEASE duration
Abstract

Background: A high reactivation of multiple sclerosis (MS) was reported in patients treated with alemtuzumab after fingolimod. We aimed to understand whether this shift enhanced the risk for reactivation in a real-life cohort. Methods: Subjects with relapsing MS, shifting from fingolimod to alemtuzumab were enrolled. We collected the following data: age, sex, disease duration, relapses after fingolimod withdrawal, new T2/gadolinium (Gd)-enhancing lesions in the last magnetic resonance imaging (MRI) during fingolimod and in the first, while on alemtuzumab, lymphocyte counts at alemtuzumab start, and Expanded Disability Status Scale (EDSS) before and after alemtuzumab. Results: We enrolled 77 patients (women 61 (79%); mean age 36.2 years (SD 9.6), and disease duration 12.3 years (SD 6.8) at fingolimod discontinuation; median washout 1.8 months). The annualised relapse rate was 0.89 during fingolimod, 1.32 during washout, and 0.15 after alemtuzumab (p = 0.001). The EDSS changed from a median of 3 (IQR 2–4) at the end of fingolimod to 2.5 after alemtuzumab (IQR 1.5–4) (p = 0.013). The washout length and the lymphocyte count before alemtuzumab were not associated with EDSS change after alemtuzumab (p = 0.59 and p = 0.33, respectively). MRI activity decreased after alemtuzumab compared to that during fingolimod (p = 0.001). At alemtuzumab start, lymphocyte counts were < 0.8 × 103/mL in 21 patients. Conclusions: In our cohort, alemtuzumab reduced relapse, new T2/Gd-enhancing lesions, and EDSS score, as compared to the previous periods (fingolimod/washout). These results were not related to washout length or lymphocyte counts. Therefore, a rapid initiation of alemtuzumab after fingolimod does not seem to be a risk factor for MS reactivation. [ABSTRACT FROM AUTHOR]

Published
2019
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42. Determinants of therapy switch in multiple sclerosis treatment-naïve patients: A real-life study.

Author

Saccà, Francesco, Lanzillo, Roberta, Signori, Alessio, Maniscalco, Giorgia T, Signoriello, Elisabetta, Lo Fermo, Salvatore, Repice, Annamaria, Annovazzi, Pietro, Baroncini, Damiano, Clerico, Marinella, Binello, Eleonora, Cerqua, Raffaella, Mataluni, Giorgia, Bonavita, Simona, Lavorgna, Luigi, Zarbo, Ignazio Roberto, Laroni, Alice, Rossi, Silvia, Pareja Gutierrez, Lorena, and La Gioia, Sara

Subjects
MULTIPLE sclerosis, MULTIPLE sclerosis treatment, DECISION making
Abstract

Background: With many options now available, first therapy choice is challenging in multiple sclerosis (MS) and depends mainly on neurologist and patient preferences. Objectives: To identify prognostic factors for early switch after first therapy choice. Methods: Newly diagnosed relapsing–remitting MS patients from 24 Italian centers were included. We evaluated the association of baseline demographics, clinical, and magnetic resonance imaging (MRI) data to the switch probability for lack of efficacy or intolerance/safety with a multivariate Cox analysis and estimated switch rates by competing risks models. Results: We enrolled 3025 patients. The overall switch frequency was 48% after 3 years. Switch risk for lack of efficacy was lower with fingolimod (hazard ratio (HR) = 0.50; p = 0.009), natalizumab (HR = 0.13; p < 0.001), dimethyl-fumarate (HR = 0.60; p = 0.037), teriflunomide (HR = 0.21; p = 0.031) as compared to interferons. Younger age (HR = 0.96; p < 0.001), diagnosis delay (HR = 1.23; p = 0.021), higher baseline Expanded Disability Status Scale (HR = 1.17; p = 0.001), and spinal cord lesions (HR = 1.46; p = 0.001) were independently associated with higher inefficacy switch rates. We found lower switch for intolerance/safety with glatiramer acetate (HR = 0.61; p = 0.001), fingolimod (HR = 0.35; p = 0.002), and dimethyl-fumarate (HR = 0.57; p = 0.022) as compared to interferons, while it increased with natalizumab (HR = 1.43; p = 0.022). Comorbidities were associated with intolerance switch (HR = 1.28; p = 0.047). Conclusion: Several factors are associated with higher switch risk in patients starting a first-line therapy and could be integrated in the decision-making process of first treatment choice. [ABSTRACT FROM AUTHOR]

Published
2019
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43. Long-term follow-up of pediatric MS patients starting treatment with injectable first-line agents: A multicentre, Italian, retrospective, observational study.

Author

Baroncini, Damiano, Zaffaroni, Mauro, Moiola, Lucia, Lorefice, Lorena, Fenu, Giuseppe, Iaffaldano, Pietro, Simone, Marta, Fanelli, Fulvia, Patti, Francesco, D'Amico, Emanuele, Capobianco, Marco, Bertolotto, Antonio, Gallo, Paolo, Margoni, Monica, Miante, Silvia, Milani, Nicoletta, Amato, Maria Pia, Righini, Isabella, Bellantonio, Paolo, and Scandellari, Cinzia

Subjects
*JOHN Cunningham virus, *SCIENTIFIC observation
Abstract

Background: Few data are available on very long-term follow-up of pediatric multiple sclerosis (MS) patients treated with disease modifying treatments (DMTs). Objectives: To present a long-term follow-up of a cohort of Pediatric-MS patients starting injectable first-line agents. Methods: Data regarding treatments, annualized relapse rate (ARR), Expanded Disability Status Scale (EDSS) score, and serious adverse event were collected. Baseline characteristics were tested in multivariate analysis to identify predictors of disease evolution. Results: In total, 97 patients were followed for 12.5 ± 3.3 years. They started therapy at 13.9 ± 2.1 years, 88 with interferons and 9 with copaxone. During the whole follow-up, 82 patients changed therapy, switching to immunosuppressors/second-line treatment in 58% of cases. Compared to pre-treatment phase, the ARR was significantly reduced during the first treatment (from 3.2 ± 2.6 to 0.7 ± 1.5, p < 0.001), and it remained low during the whole follow-up (0.3 ± 0.2, p < 0.001). At last observation, 40% had disability worsening, but EDSS score remained <4 in 89%. One patient died at age of 23 years due to MS. One case of natalizumab-related progressive multifocal encephalopathy (PML) was recorded. Starting therapy before 12 years of age resulted in a better course of disease in multivariate analysis. Conclusion: Pediatric-MS patients benefited from interferons/copaxone, but the majority had to switch to more powerful drugs. Starting therapy before 12 years of age could lead to a more favorable outcome. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Natalizumab Discontinuation after the 24th Course: Which Is Way? The TY-STOP Study

Author

Marinella CLERICO, Mercanti, Stefania, Piazza, Federico, Gned, Dario, Morra, Vincenzo Brescia, Lanzillo, Roberta, Amato, Luca, Quarantelli, Mario, Ghezzi, Angelo, Bianchi, Anna, Baroncini, Damiano, Gibbin, Marco, Vargas, Joseph, Salemi, Giuseppe, Realmuto, Sabrina, Ferro, Maria Teresa, Vitetta, Francesca, Sola, Patrizia, Paolicelli, Damiano, Trojano, Maria, Durelli, Luca, Clerico, M, De Mercanti, S, Piazza, F, Gned, D, Morra, V, Lanzillo, R, Amato, L, Quarantelli, M, Ghezzi, A, Bianchi, A, Baroncini, D, Gibbin, M, Vargas, J, Salemi, G, Realmuto, S, Ferrò, MT, Vitetta, F, Sola, P, Paolicelli, D, Trojano, M, Durelli, L, Clerico, M., De Mercanti, S., Piazza, F., Gned, D., BRESCIA MORRA, Vincenzo, Lanzillo, Roberta, Amato, L., Quarantelli, M., Ghezzi, A., Bianchi, A., Baroncini, D., Gibbin, M., Vargas, J., Salemi, G., Realmuto, S., Ferro, Mt, Vitetta, F., Sola, P., Paolicelli, D., Trojano, M., and Durelli, L.

Subjects
Multiple Sclerosis, Natalizumab, multiple sclerosis, Natalizumab, Settore MED/26 - Neurologia, MRi
Published
2013

49. Natalizumab Therapy, How to Treat How to Stop: The TY-STOP Study (P7.216)

Author

Clerico, Marinella, primary, De Mercanti, Stefania, additional, Piazza, Federico, additional, Virgilio, Eleonora, additional, Gned, Dario, additional, Brescia Morra, Vincenzo, additional, Lanzillo, Roberta, additional, Amato, Luca, additional, Quarantelli, Mario, additional, Ghezzi, Angelo, additional, Bianchi, Anna, additional, Baroncini, Damiano, additional, Salemi, Giuseppe, additional, Realmuto, Sabrina, additional, Ferrò, Maria Teresa, additional, Vitetta, Francesca, additional, Superti, Giulia, additional, Cavalla, Paola, additional, D'Onghia, Mariangela, additional, Paolicelli, Damiano, additional, Schiavetti, Irene, additional, Sormani, Maria Pia, additional, Pinessi, Lorenzo, additional, Trojano, Maria, additional, and Durelli, Luca, additional

Published
2014
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50. Natalizumab Discontinuation after the 24 th Course: Which Is Way? The TY-STOP Study (P01.197)

Author

Clerico, Marinella, primary, De Mercanti, Stefania, additional, Piazza, Federico, additional, Gned, Dario, additional, Brescia Morra, Vincenzo, additional, Lanzillo, Roberta, additional, Amato, Luca, additional, Quarantelli, Mario, additional, Ghezzi, Angelo, additional, Bianchi, Anna, additional, Baroncini, Damiano, additional, Gibbin, Marco, additional, Vargas, Joseph, additional, Salemi, Giuseppe, additional, Realmuto, Sabrina, additional, Ferrò, Maria Teresa, additional, Vitetta, Francesca, additional, Sola, Patrizia, additional, Paolicelli, Damiano, additional, Trojano, Maria, additional, and Durelli, Luca, additional

Published
2013
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