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7. List of Contributors

Author

Agarwal, Atul, primary, Atkinson, John P., additional, Barlow, Paul N., additional, Barnum, Scott R., additional, Bettuzzi, Saverio, additional, Blom, Anna M., additional, Boackle, Susan A., additional, Bohlson, Suzanne, additional, Bullard, Daniel C., additional, Cauvi, David M., additional, Cedzyński, Maciej, additional, Christy, Joseph M., additional, Coulthard, Liam G., additional, DiScipio, Richard G., additional, Drouet, Christian, additional, Ferreira, Viviana P., additional, Fishelson, Zvi, additional, Gaboriaud, Christine, additional, Ghannam, Arije, additional, Ghebrehiwet, Berhane, additional, Ghiran, Ionita, additional, Hawksworth, Owen ​A., additional, Huang, Mingjun, additional, Isenman, David E., additional, Jensenius, Jens C., additional, Kemper, Claudia, additional, Kilpatrick, David C., additional, Laskowski, Jennifer, additional, Liszewski, M. Kathryn, additional, Manne, Kartik, additional, Matsushita, Misao, additional, Morgan, Paul, additional, Naponelli, Valeria, additional, Narayana, Sthanam V.L., additional, Nicholson-Weller, Anne, additional, Ohtani, Katsuki, additional, Okrój, Marcin, additional, Orozco, Luz D., additional, Pangburn, Michael K., additional, Pihl, Ramus, additional, Podos, Steven D., additional, Pollard, Kenneth M., additional, Ponard, Denise, additional, Riesbeck, Kristian, additional, Rossi, Véronique, additional, Schein, Theresa N., additional, Su, Yu-Ching, additional, Świerzko, Anna S., additional, Thielens, Nicole M., additional, Thiel, Steffen, additional, Thurman, Joshua M., additional, Toomey, Christopher B., additional, van Lookeren Campagne, Menno, additional, Wakamiya, Nobutaka, additional, Wetsel, Rick A., additional, and Woodruff, Trent ​M., additional

Published
2018
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11. N

Author

Cohen, Daniel A., Hornung, David E., Mays, Lawrence, Douglas, Rodney, Kennedy, Henry, Knoblauch, Kenneth, Martin, Kevan, Abramov, Valery V., Gontova, Irina A., Abramova, Tatjana Ya., Kozlov, Vladimir A., Kusnecov, Alexander, Benchenane, Karim, Zugaro, Michaël, Wiener, Sidney, Witt, Martin, Moschovakis, Adonis, Braun, Anna Katharina, Kuratani, Shigeru, Murakami, Fujio, Starkweather, Angela, Dalezios, Yannis, Aihara, Kazuyuki, Okada, Masato, Adachi, Masaharu, Watanabe, Masataka, Rokni, Uri, Smith, Peter G., Richter, Diethelm W., Müller, Michael, Griffiths, M., Neal, J. W, Gasque, P., Bernhardi, Rommy von, Guillemin, Gilles J., Buijs, Ruud M., Kalsbeek, Andries, Darlington, Cynthia L., Swaab, Dick F., Lucassen, Paul J., Huitinga, Inge, Bao, Ai-Min, Ladwig, Bernd, Ohl, Frank W., Schnitzler, Hans-Ulrich, Denzinger, Annette, Takahashi, Terry, Warzecha, Anne-Kathrin, Kern, Roland, Oishi, Koji, Nakajima, Kazunori, Bernardino, Liliana, Agasse, Fabienne, Malva, João O., Bird, Thomas D., Alonso, Mariana, Dubayle, David, Menetrey, D., Haddad, John J., Lobell, Anna, Stahel, Philip F., Felderhoff-Mueser, Ursula, Barnum, Scott R., Jafarian-Tehrani, Mehrnaz, Mizuno, Tetsuya, Dietrich, W. Dalton, Keane, Robert W., Han, Jung-Soo, Dhaini, Hassan R., Spain, William J., Mandairon, Nathalie, Didier, Anne, Rich, Mark M., Kudo, Yoshihisa, Ruangkittisakul, Araya, Ballanyi, Klaus, Syed, Naweed I., Petzold, Axel, Rumbaugh, Jeffrey A., Nath, Avindra, Aldskogius, Håkan, Delgado-García, José M., Kengaku, Mineko, Kim, Joanne SM, Zhen, Mei, Mathie, Alistair, Veale, Emma L., Stengel, Maike, Baron, Ralf, Samson, Willis K., Chee, Melissa J. S., Colmers, William F., Smith, Paul F., Pauen, Michael, Elliott, Stacy L., Northoff, Georg, Jorna, René J., Inoue, Kazuhide, Kawabe, Hiroshi, Varoqueaux, Frederique, Brose, Nils, Tanaka, Kohichi, Whelan, Patrick J., Petralia, Ronald S., Wenthold, Robert J., Ramer, Matt S., McPhail, Lowell T., Mullaney, Ian, Widera, Darius, Kaltschmidt, Christian, Kaltschmidt, Barbara, Pennypacker, Keith R., Pollock, Glen, Saporta, Samuel, Koerber, H. Richard, Handwerker, Herrmann O., Smale, Laura, Nunez, Antonio A., Shimkin, Nahum, Tse, Frederick W., Wang, Nan, Yan, Lei, Tse, Amy, Covey, Ellen, Travagli, R. Alberto, Binder, Marc D., editor, Hirokawa, Nobutaka, editor, and Windhorst, Uwe, editor

Published
2009
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22. Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis

Author

Woehrl, Bianca, Brouwer, Matthijs C., Murr, Carmen, Heckenberg, Sebastiaan G.B., Baas, Frank, Pfister, Hans W., Zwinderman, Aeilko H., Morgan, B. Paul, Barnum, Scott R., Ende, Arie van der, Koedel, Uwe, and Beek, Diederik van de

Subjects
Bacterial meningitis -- Patient outcomes -- Research -- Genetic aspects, Single nucleotide polymorphisms -- Research -- Physiological aspects -- Genetic aspects, Complement (Immunology) -- Physiological aspects -- Research -- Genetic aspects, Health care industry
Abstract

Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the proinflammatory response in the subarachnoid space. The complement system, which mediates key inflammatory processes, has been implicated as a modulator of pneumococcal meningitis disease severity in animal studies. Additionally, SNPs in genes encoding complement pathway proteins have been linked to susceptibility to pneumococcal infection, although no associations with disease severity or outcome have been established. Here, we have performed a robust prospective nationwide genetic association study in patients with bacterial meningitis and found that a common nonsynonymous complement component 5 (C5) SNP (rs17611) is associated with unfavorable disease outcome. C5 fragment levels in cerebrospinal fluid (CSF) of patients with bacterial meningitis correlated with several clinical indicators of poor prognosis. Consistent with these human data, C5a receptor-deficient mice with pneumococcal meningitis had lower CSF wbc counts and decreased brain damage compared with WT mice. Adjuvant treatment with C5-specific monoclonal antibodies prevented death in all mice with pneumococcal meningitis. Thus, our results suggest C5-specific monoclonal antibodies could be a promising new antiinflammatory adjuvant therapy for pneumococcal meningitis., Introduction Community-acquired bacterial meningitis continues to exact a heavy toll, even in developed countries, despite the implementation of childhood vaccination programs and effective antimicrobial agents (1, 2). The most common [...]

Published
2011
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35. Complement anaphylatoxin receptors on neurons: new tricks for old receptors?

Author

Nataf, Serge, Stahel, Philip F., Davoust, Nathalie, and Barnum, Scott R.

Subjects
Neurons -- Physiological aspects, Peptide hormones -- Receptors, Health, Psychology and mental health
Abstract

Activation of the complement system has been reported in a variety of inflammatory diseases and neurodegenerative processes of the CNS. Recent evidence indicates that complement proteins and receptors are synthesized on or by glial cells and, surprisingly, neurons. Among these proteins are the receptors for the chemotactic and anaphylactic peptides, C5a and C3a, which are the most-potent mediators of complement inflammatory functions. The functions of glial-cell C3a and C5a receptors (C3aR and C5aR) appear to be similar to immune-cell C3aRs and C5aRs. However, little is known about the roles these receptors might have on neurons. Indeed, when compared with glial cells, neurons display a distinct pattern of C3aR and C5aR expression, in either the normal or the inflamed CNS.These findings suggest unique functions for these receptors on neurons.

Published
1999

36. The Complement FactsBook Ed. 2

Author

Barnum, Scott R., Barnum, Scott R., Barnum, Scott R., and Barnum, Scott R.

Abstract

The Complement FactsBook, Second Edition, provides in-depth insights and an overview of the components of the complement system. This new edition highlights the use of newly recommended complement nomenclature, covering new pathways and proteins and adding information on mouse homologs. It is a completely revised and updated edition containing entries on all components of the complement system, and is an excellent source of one-stop shopping for complement information and references. It is the most convenient compilation of biochemical, biological and molecular biology for complementologists and those new in the field. This new edition is expanded to include relevant updates and topics that have evolved since the last edition was published, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. Introduces complement function, simply described for each function Includes the cDNA sequences that are marked with intron/exon boundaries, facilitating genetic studies Presents detailed structural information, including cDNA and gene structure for all proteins Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, families

Published
2017

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