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Background Achieving hepatitis C elimination is hampered by the costs of treatment and the need to treat hard-to-reach populations. Treatment access could be widened by shortening treatment, but limited research means it is unclear which strategies could achieve sufficiently high cure rates to be acceptable. We present the statistical aspects of a multi-arm trial designed to test multiple strategies simultaneously with a monitoring mechanism to detect and stop those with unacceptably low cure rates quickly. Methods The VIETNARMS trial will factorially randomise patients to three randomisations. We will use Bayesian monitoring at interim analyses to detect and stop recruitment into unsuccessful strategies, defined as a >0.95 posterior probability of the true cure rate being <90%. Here, we tested the operating characteristics of the stopping guideline, planned the timing of the interim analyses and explored power at the final analysis. Results A beta(4.5, 0.5) prior for the true cure rate produces <0.05 probability of incorrectly stopping a group with true cure rate >90%. Groups with very low cure rates (<60%) are very likely (>0.9 probability) to stop after ~25% patients are recruited. Groups with moderately low cure rates (80%) are likely to stop (0.7 probability) before the end of recruitment. Interim analyses 7, 10, 13 and 18 months after recruitment commences provide good probabilities of stopping inferior groups. For an overall true cure rate of 95%, power is >90% to detect non-inferiority in the regimen and strategy comparisons using 5% and 10% margins respectively, regardless of the control cure rate, and to detect a 5% absolute difference in the ribavirin comparison. Conclusions The operating characteristics of the stopping guideline are appropriate and interim analyses can be timed to detect failing groups at various stages., Comment: 26 pages, 2 figures

Electron spins in gate-defined quantum dots provide a promising platform for quantum computation. In particular, spin-based quantum computing in gallium arsenide takes advantage of the high quality of semiconducting materials, reliability in fabricating arrays of quantum dots, and accurate qubit operations. However, the effective magnetic noise arising from the hyperfine interaction with uncontrolled nuclear spins in the host lattice constitutes a major source of decoherence. Low frequency nuclear noise, responsible for fast (10 ns) inhomogeneous dephasing, can be removed by echo techniques. High frequency nuclear noise, recently studied via echo revivals, occurs in narrow frequency bands related to differences in Larmor precession of the three isotopes $\mathbf{^{69}Ga}$, $\mathbf{^{71}Ga}$, and $\mathbf{^{75}As}$. Here we show that both low and high frequency nuclear noise can be filtered by appropriate dynamical decoupling sequences, resulting in a substantial enhancement of spin qubit coherence times. Using nuclear notch filtering, we demonstrate a spin coherence time ($\mathbf{T_{2}}$) of 0.87 ms, five orders of magnitude longer than typical exchange gate times, and exceeding the longest coherence times reported to date in Si/SiGe gate-defined quantum dots., Comment: 10 pages, including main text (5 figures) and supplementary information (2 figures)

The Mu2e experiment at Fermilab will search for charged lepton flavor violation via the coherent conversion process mu- N --> e- N with a sensitivity approximately four orders of magnitude better than the current world's best limits for this process. The experiment's sensitivity offers discovery potential over a wide array of new physics models and probes mass scales well beyond the reach of the LHC. We describe herein the preliminary design of the proposed Mu2e experiment. This document was created in partial fulfillment of the requirements necessary to obtain DOE CD-2 approval., Comment: compressed file, 888 pages, 621 figures, 126 tables; full resolution available at http://mu2e.fnal.gov; corrected typo in background summary, Table 3.4

A measurement is presented of the neutron production rate in lead by high energy cosmic-ray muons at a depth of 2850 m water equivalent (w.e.) and a mean muon energy of 260 GeV. The measurement exploits the delayed coincidences between muons and the radiative capture of induced neutrons in a highly segmented tonne scale plastic scintillator detector. Detailed Monte Carlo simulations reproduce well the measured capture times and multiplicities and, within the dynamic range of the instrumentation, the spectrum of energy deposits. By comparing measurements with simulations of neutron capture rates a neutron yield in lead of (5.78^{+0.21}_{-0.28}) x 10^{-3} neutrons/muon/(g/cm^{2}) has been obtained. Absolute agreement between simulation and data is of order 25%. Consequences for deep underground rare event searches are discussed., Comment: 12 pages, 13 figures

Mu2e at Fermilab will search for charged lepton flavor violation via the coherent conversion process mu- N --> e- N with a sensitivity approximately four orders of magnitude better than the current world's best limits for this process. The experiment's sensitivity offers discovery potential over a wide array of new physics models and probes mass scales well beyond the reach of the LHC. We describe herein the conceptual design of the proposed Mu2e experiment. This document was created in partial fulfillment of the requirements necessary to obtain DOE CD-1 approval, which was granted July 11, 2012., Comment: 562 pages, 339 figures

We studied the application of statistical reconstruction algorithms, namely maximum likelihood and least squares methods, to the problem of event reconstruction in a dual phase liquid xenon detector. An iterative method was developed for in-situ reconstruction of the PMT light response functions from calibration data taken with an uncollimated gamma-ray source. Using the techniques described, the performance of the ZEPLIN-III dark matter detector was studied for 122 keV gamma-rays. For the inner part of the detector (R<100 mm), spatial resolutions of 13 mm and 1.6 mm FWHM were measured in the horizontal plane for primary and secondary scintillation, respectively. An energy resolution of 8.1% FWHM was achieved at that energy. The possibility of using this technique for improving performance and reducing cost of scintillation cameras for medical applications is currently under study., Comment: 8 pages, 7 figures, in the Conference Record of IEEE NSS 2011, accepted for publication in IEEE Trans. on Nuc. Sci

ZEPLIN-III is a two-phase xenon direct dark matter experiment located at the Boulby Mine (UK). After its first science run in 2008 it was upgraded with: an array of low background photomultipliers, a new anti-coincidence detector system with plastic scintillator and an improved calibration system. After 319 days of data taking the second science run ended in May 2011. In this paper we describe the instrument performance with emphasis on the position and energy reconstruction algorithm and summarise the final science results., Comment: Submitted to PSD9 conference proceedings

Plastic scintillators are widely used in industry, medicine and scientific research, including nuclear and particle physics. Although one of their most common applications is in neutron detection, experimental data on their response to low-energy nuclear recoils are scarce. Here, the relative scintillation efficiency for neutron-induced nuclear recoils in a polystyrene-based plastic scintillator (UPS-923A) is presented, exploring recoil energies between 125 keV and 850 keV. Monte Carlo simulations, incorporating light collection efficiency and energy resolution effects, are used to generate neutron scattering spectra which are matched to observed distributions of scintillation signals to parameterise the energy-dependent quenching factor. At energies above 300 keV the dependence is reasonably described using the semi-empirical formulation of Birks and a kB factor of (0.014+/-0.002) g/MeVcm^2 has been determined. Below that energy the measured quenching factor falls more steeply than predicted by the Birks formalism., Comment: 8 pages, 9 figures

We report experimental upper limits on WIMP-nucleon elastic scattering cross sections from the second science run of ZEPLIN-III at the Boulby Underground Laboratory. A raw fiducial exposure of 1,344 kg.days was accrued over 319 days of continuous operation between June 2010 and May 2011. A total of eight events was observed in the signal acceptance region in the nuclear recoil energy range 7-29 keV, which is compatible with background expectations. This allows the exclusion of the scalar cross-section above 4.8E-8 pb near 50 GeV/c^2 WIMP mass with 90% confidence. Combined with data from the first run, this result improves to 3.9E-8 pb. The corresponding WIMP-neutron spin-dependent cross-section limit is 8.0E-3 pb. The ZEPLIN programme reaches thus its conclusion at Boulby, having deployed and exploited successfully three liquid xenon experiments of increasing reach.

We present an experimental study of single electron emission in ZEPLIN-III, a two-phase xenon experiment built to search for dark matter WIMPs, and discuss applications enabled by the excellent signal-to-noise ratio achieved in detecting this signature. Firstly, we demonstrate a practical method for precise measurement of the free electron lifetime in liquid xenon during normal operation of these detectors. Then, using a realistic detector response model and backgrounds, we assess the feasibility of deploying such an instrument for measuring coherent neutrino-nucleus elastic scattering using the ionisation channel in the few-electron regime. We conclude that it should be possible to measure this elusive neutrino signature above an ionisation threshold of $\sim$3 electrons both at a stopped pion source and at a nuclear reactor. Detectable signal rates are larger in the reactor case, but the triggered measurement and harder recoil energy spectrum afforded by the accelerator source enable lower overall background and fiducialisation of the active volume.

ZE3RA is the software package responsible for processing the raw data from the ZEPLIN-III dark matter experiment and its reduction into a set of parameters used in all subsequent analyses. The detector is a liquid xenon time projection chamber with scintillation and electroluminescence signals read out by an array of 31 photomultipliers. The dual range 62-channel data stream is optimised for the detection of scintillation pulses down to a single photoelectron and of ionisation signals as small as those produced by single electrons. We discuss in particular several strategies related to data filtering, pulse finding and pulse clustering which are tuned to recover the best electron/nuclear recoil discrimination near the detection threshold, where most dark matter elastic scattering signatures are expected. The software was designed assuming only minimal knowledge of the physics underlying the detection principle, allowing an unbiased analysis of the experimental results and easy extension to other detectors with similar requirements.

Scintillation and ionisation yields for nuclear recoils in liquid xenon above 10 keVnr (nuclear recoil energy) are deduced from data acquired using broadband Am-Be neutron sources. The nuclear recoil data from several exposures to two sources were compared to detailed simulations. Energy-dependent scintillation and ionisation yields giving acceptable fits to the data were derived. Efficiency and resolution effects are treated using a light collection Monte Carlo, measured photomultiplier response profiles and hardware trigger studies. A gradual fall in scintillation yield below ~40 keVnr is found, together with a rising ionisation yield; both are in good agreement with the latest independent measurements. The analysis method is applied to both the most recent ZEPLIN-III data, acquired with a significantly upgraded detector and a precision-calibrated Am-Be source, as well as to the earlier data from the first run in 2008. A new method for deriving the recoil scintillation yield, which includes sub-threshold S1 events, is also presented which confirms the main analysis., Comment: 7 pages, 7 figures

We examine electron and nuclear recoil backgrounds from radioactivity in the ZEPLIN-III dark matter experiment at Boulby. The rate of low-energy electron recoils in the liquid xenon WIMP target is 0.75$\pm$0.05 events/kg/day/keV, which represents a 20-fold improvement over the rate observed during the first science run. Energy and spatial distributions agree with those predicted by component-level Monte Carlo simulations propagating the effects of the radiological contamination measured for materials employed in the experiment. Neutron elastic scattering is predicted to yield 3.05$\pm$0.5 nuclear recoils with energy 5-50 keV per year, which translates to an expectation of 0.4 events in a 1-year dataset in anti-coincidence with the veto detector for realistic signal acceptance. Less obvious background sources are discussed, especially in the context of future experiments. These include contamination of scintillation pulses with Cherenkov light from Compton electrons and from $\beta$ activity internal to photomultipliers, which can increase the size and lower the apparent time constant of the scintillation response. Another challenge is posed by multiple-scatter $\gamma$-rays with one or more vertices in regions that yield no ionisation. If the discrimination power achieved in the first run can be replicated, ZEPLIN-III should reach a sensitivity of $\sim 1 \times 10^{-8}$ pb$\cdot$year to the scalar WIMP-nucleon elastic cross-section, as originally conceived., Comment: 12 pages, 5 figures

The ZEPLIN-III experiment is operating in its second phase at the Boulby Underground Laboratory in search of dark matter WIMPs. The major upgrades to the instrument over its first science run include lower background photomultiplier tubes and installation of a plastic scintillator veto system. Performance results from the veto detector using calibration and science data in its first six months of operation in coincidence with ZEPLIN-III are presented. With fully automated operation and calibration, the veto system has maintained high stability and achieves near unity live time relative to ZEPLIN-III. Calibrations with a neutron source demonstrate a rejection of 60% of neutron-induced nuclear recoils in ZEPLIN-III that might otherwise be misidentified as WIMPs. This tagging efficiency reduces the expected untagged nuclear recoil background from neutrons during science data taking to a very low rate of ~0.2 events per year in the WIMP acceptance region. Additionally, the veto detector provides rejection of 28% of gamma-ray induced background events, allowing the sampling of the dominant source of background in ZEPLIN-III - multiple scatter gamma-rays with rare topologies. Since WIMPs will not be tagged by the veto detector, and tags due to gamma-rays and neutrons are separable, this population of multiple scatter events may be characterised without biasing the analysis of candidate WIMP signals in the data.

The design, optimisation and construction of an anti-coincidence veto detector to complement the ZEPLIN-III direct dark matter search instrument is described. One tonne of plastic scintillator is arranged into 52 bars individually read out by photomultipliers and coupled to a gadolinium-loaded passive polypropylene shield. Particular attention has been paid to radiological content. The overall aim has been to achieve a veto detector of low threshold and high efficiency without the creation of additional background in ZEPLIN-III, all at a reasonable cost. Extensive experimental measurements of the components have been made, including radioactivity levels and performance characteristics. These have been used to inform a complete end-to-end Monte Carlo simulation that has then been used to calculate the expected performance of the new instrument, both operating alone and as an anti-coincidence detector for ZEPLIN-III. The veto device will be capable of rejecting over 65% of coincident nuclear recoil events from neutron background in the energy range of interest in ZEPLIN-III. This will reduce the background in ZEPLIN-III from ~0.4 to ~0.14 events per year in the WIMP acceptance region, a significant factor in the event of a non-zero observation. Furthermore, in addition to providing valuable diagnostic capabilities, the veto is capable of tagging over 15% for gamma-ray rejection, all whilst contributing no significant additional background. In conjunction with the replacement of the internal ZEPLIN-III photomultiplier array, the new veto is expected to improve significantly the sensitivity of the ZEPLIN-III instrument to dark matter, allowing spin independent WIMP-nucleon cross sections below 1E-8 pb to be probed.

We present limits on the WIMP-nucleon cross section for inelastic dark matter derived from the 2008 run of ZEPLIN-III. Cuts, notably on scintillation pulse shape and scintillation-to-ionisation ratio, give a net exposure of 63 kg.days in the range 20-80keV nuclear recoil energy, in which 6 events are observed. Upper limits on signal rate are derived from the maximum empty patch in the data. Under standard halo assumptions a small region of parameter space consistent, at 99% CL, with causing the 1.17 ton.year DAMA modulation signal is allowed at 90% CL: it is in the mass range 45-60 GeV with a minimum CL of 88%, again derived from the maximum patch. This is the tightest constraint on that explanation of the DAMA result yet presented using a xenon target., Comment: 4 pages, 5 figures. Updated with 1.17 ton.year DAMA results.

A method is described that allows calibration and assessment of the linearity of response of an array of photomultiplier tubes. The method does not require knowledge of the photomultiplier single photoelectron response model and uses science data directly, thus eliminating the need for dedicated data sets. In this manner all photomultiplier working conditions (e.g. temperature, external fields, etc) are exactly matched between calibration and science acquisitions. This is of particular importance in low background experiments such as ZEPLIN-III, where methods involving the use of external light sources for calibration are severely constrained., Comment: 15 pages, 6 figures

We present new experimental constraints on the WIMP-nucleon spin-dependent elastic cross-sections using data from the first science run of ZEPLIN-III, a two-phase xenon experiment searching for galactic dark matter WIMPs based at the Boulby mine. Analysis of $\sim$450 kg$\cdot$days fiducial exposure revealed a most likely signal of zero events, leading to a 90%-confidence upper limit on the pure WIMP-neutron cross-section of $\sigma_n=1.8\times 10^{-2}$ pb at 55 GeV/$c^2$ WIMP mass. Recent calculations of the nuclear spin structure based on the Bonn CD nucleon-nucleon potential were used for the odd-neutron isotopes $^{129}$Xe and $^{131}$Xe. These indicate that the sensitivity of xenon targets to the spin-dependent WIMP-proton interaction is much lower than implied by previous calculations, whereas the WIMP-neutron sensitivity is impaired only by a factor of $\sim$2., Comment: 4 pages, 2 figures

The ZEPLIN-III experiment in the Palmer Underground Laboratory at Boulby uses a 12kg two-phase xenon time projection chamber to search for the weakly interacting massive particles (WIMPs) that may account for the dark matter of our Galaxy. The detector measures both scintillation and ionisation produced by radiation interacting in the liquid to differentiate between the nuclear recoils expected from WIMPs and the electron recoil background signals down to ~10keV nuclear recoil energy. An analysis of 847kg.days of data acquired between February 27th 2008 and May 20th 2008 has excluded a WIMP-nucleon elastic scattering spin-independent cross-section above 8.1x10(-8)pb at 55GeV/c2 with a 90% confidence limit. It has also demonstrated that the two-phase xenon technique is capable of better discrimination between electron and nuclear recoils at low-energy than previously achieved by other xenon-based experiments., Comment: 12 pages, 17 figures

We investigate a hypothesis regarding the origin of the scalelength in halos formed in cosmological N-body simulations. This hypothesis can be viewed as an extension of an earlier idea put forth by Merritt and Aguilar. Our findings suggest that a phenomenon related to the radial orbit instability is present in such halos and is responsible for density profile shapes. This instability sets a scalelength at which the velocity dispersion distribution changes rapidly from isotropic to radially anisotropic. This scalelength is reflected in the density distribution as the radius at which the density profile changes slope. We have tested the idea that radially dependent velocity dispersion anisotropy leads to a break in density profile shape by manipulating the input of a semi-analytic model to imitate the velocity structure imposed by the radial orbit instability. Without such manipulation, halos formed are approximated by single power-law density profiles and isotropic velocity distributions. Halos formed with altered inputs display density distributions featuring scalelengths and anisotropy profiles similar to those seen in cosmological N-body simulations., Comment: accepted for publication in ApJ