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4. Exploring the impact of COVID-19 on the postnatal period for first-time mothers experiencing postnatal depression : a thematic analysis

Author

Barnes, Rachel

Subjects
postnatal depression, postnatal period, COVID-19, maternal mental health, thematic analysis
Abstract

Research has identified the negative impact that postnatal depression has on new mothers' wellbeing and that of their family. With mothers in the postnatal period facing unique challenges during the COVID-19 pandemic, there is an increased need to explore the effects of the pandemic on mothers experiencing postnatal depression to understand where support may be needed. A systematic literature review highlighted a gap in this area of inquiry. This study employed a qualitative approach to explore the impact of COVID-19 on the postnatal period for first-time mothers experiencing postnatal depression. Using semi-structured interviews, this research sought to understand the experiences of 12 first-time mothers who experienced postnatal depression during the pandemic. Five main themes were identified through analysis: 'fear of COVID-19', 'being alone', 'relationship with services', 'impact on partner relationships' and 'coping strategies'. Nine respective subthemes were constructed, which identified that COVID-19 had a predominantly negative impact on the wellbeing of new mothers experiencing postnatal depression, however, there were some advantages to their partner being home for several participants. Findings are discussed in relation to the wider literature and the implications are presented, alongside a critical appraisal of the research. Recommendations for future research will also be outlined.

Published
2023
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5. Eating disorders in weight-related therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight management

Author

Jebeile, Hiba, Lister, Natalie B, Libesman, Sol, Hunter, Kylie E, McMaster, Caitlin M, Johnson, Brittany J, Baur, Louise A, Paxton, Susan J, Garnett, Sarah P, Ahern, Amy L, Wilfley, Denise E, Maguire, Sarah, Sainsbury, Amanda, Steinbeck, Katharine, Askie, Lisa, Braet, Caroline, Hill, Andrew J, Nicholls, Dasha, Jones, Rebecca A, Dammery, Genevieve, Grunseit, Alicia M, Cooper, Kelly, Kyle, Theodore K, Heeren, Faith A, Quigley, Fiona, Barnes, Rachel D, Bean, Melanie K, Beaulieu, Kristine, Bonham, Maxine, Boutelle, Kerri N, Branco, Braulio Henrique Magnani, Calugi, Simona, Cardel, Michelle I, Carpenter, Kelly, Cheng, Hoi Lun, Grave, Riccardo Dalle, Danielsen, Yngvild S, Demarzo, Marcelo, Dordevic, Aimee, Eichen, Dawn M, Goldschmidt, Andrea B, Hilbert, Anja, Houben, Katrijn, do Prado, Mara Lofrano, Martin, Corby K, McTiernan, Anne, Mensinger, Janell L, Pacanowski, Carly, do Prado, Wagner Luiz, Ramalho, Sofia M, Raynor, Hollie A, Rieger, Elizabeth, Robinson, Eric, Salvo, Vera, Sherwood, Nancy E, Simpson, Sharon A, Skjakodegard, Hanna F, Smith, Evelyn, Partridge, Stephanie, Tanofsky-Kraff, Marian, Taylor, Rachael W, Van Eyck, Annelies, Varady, Krista A, Vidmar, Alaina P, Whitelock, Victoria, Yanovski, Jack, Seidler, Anna L, and Collaboration, on behalf of the Eating Disorders In weight-related Therapy

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Brain Disorders, Obesity, Clinical Research, Mental Illness, Behavioral and Social Science, Eating Disorders, Nutrition, Mental Health, Clinical Trials and Supportive Activities, Prevention, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, 6.6 Psychological and behavioural, Mental health, Metabolic and endocrine, Stroke, Oral and gastrointestinal, Adult, Adolescent, Humans, Overweight, Feeding and Eating Disorders, Behavior Therapy, Systematic Reviews as Topic, Meta-Analysis as Topic, Eating Disorders In weight-related Therapy (EDIT) Collaboration, General Science & Technology
Abstract

The Eating Disorders In weight-related Therapy (EDIT) Collaboration brings together data from randomised controlled trials of behavioural weight management interventions to identify individual participant risk factors and intervention strategies that contribute to eating disorder risk. We present a protocol for a systematic review and individual participant data (IPD) meta-analysis which aims to identify participants at risk of developing eating disorders, or related symptoms, during or after weight management interventions conducted in adolescents or adults with overweight or obesity. We systematically searched four databases up to March 2022 and clinical trials registries to May 2022 to identify randomised controlled trials of weight management interventions conducted in adolescents or adults with overweight or obesity that measured eating disorder risk at pre- and post-intervention or follow-up. Authors from eligible trials have been invited to share their deidentified IPD. Two IPD meta-analyses will be conducted. The first IPD meta-analysis aims to examine participant level factors associated with a change in eating disorder scores during and following a weight management intervention. To do this we will examine baseline variables that predict change in eating disorder risk within intervention arms. The second IPD meta-analysis aims to assess whether there are participant level factors that predict whether participation in an intervention is more or less likely than no intervention to lead to a change in eating disorder risk. To do this, we will examine if there are differences in predictors of eating disorder risk between intervention and no-treatment control arms. The primary outcome will be a standardised mean difference in global eating disorder score from baseline to immediately post-intervention and at 6- and 12- months follow-up. Identifying participant level risk factors predicting eating disorder risk will inform screening and monitoring protocols to allow early identification and intervention for those at risk.

Published
2023

6. One-Year Anti-VEGF Therapy Outcomes in Diabetic Macular Edema Based on Treatment Intensity: Data from the Fight Retinal Blindness! Registry

Author

Miri, Admir, Fung, Adrian, Higueras, Alejandro, Invernizzi, Alessandro, Hamilton, Alex, Cohn, Amy, Vanderschueren, Ann, Wolff, Benjamin, Walid, Bougamha, Hennings, Charles, Chung, Charmaine, Hornsby, Chris, Rethati, Cinthia, Barthelmes, Daniel, Villoria, Daniel Velazquez, Squirrell, David, Chan, Derek, Chong, Elaine, Mangelschots, Els, Carreño, Ester, Baudin, Florian, Viola, Francesco, Lavid, Francisco Javier, Kok, Gerhard, Furness, Graham, Michel, Guillaume, Mack, Heather, Steiner, Helen, Mehta, Hemal, Reddie, Ian, Acton, James, Wells, Jane, Arnold, Jennifer, Suarez, Joel, Gilhotra, Jolly, Oday, Justin, Ceklic, Lala, Sararols, Laura, Manning, Les, Chow, Li Ping, OToole, Louise, Cordoves, Luis, Arrazola, Maite, Tena Sempere, María Eugenia, Navarro, Maria Pilar, Gillies, Mark, Morgan, Mark, Núñez, Marta Rodriguez, Weber, Michel, Castilla Marti, Miguel, de la Fuente, Miguel, Asencio Duran, Monica, Jaross, Nandor, Muñoz, Pablo Catalán, Carnota, Pablo, Lockie, Patrick, Beaumont, Paul, Hinchcliffe, Peter, Gabrielle, Pierre-Henry, Calvo, Pilar, Barnes, Rachel, Chalasani, Raj, Barry, Richard, Chong, Robert, Gallego-Pinazo, Roberto, Ferrier, Ross, Fraser-Bell, Samantha, Allieu, Sandrine, Wickremasinghe, Sanjeev, Tick, Sarah, Welch, Sarah, Moreno, Saturnino Manuel Gismero, Nothling, Simon, Aparicio-Sanchis, Sonia, Vujosevic, Stela, Young, Stephanie, Wan, Sue, Tan, Terence, Guillaumie, Tremeur, Daien, Vincent, Kheir, Wajiha, Valldeperas, Xavier, Louw, Zanne, Bashshur, Ziad, Hashimoto, Yohei, Kibret, Getiye Dejenu, Kheir, Wajiha Jurdi, O'Toole, Louise, and Creuzot-Garcher, Catherine

Published
2024
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16. One-year anti-VEGF therapy outcomes in diabetic macular edema based on treatment intensity: Data from the FRB! registry

Author

Mehta, Hemal, primary, Gabrielle, Pierre-Henry, additional, Hashimoto, Yohei, additional, Kibret, Getiye Dejenu, additional, Arnold, Jennifer, additional, Guillaumie, Tremeur, additional, Kheir, Wajiha Jurdi, additional, Kok, Gerhard, additional, Vujosevic, Stela, additional, O'Toole, Louise, additional, Mangelschots, Els, additional, Jaross, Nandor, additional, Ceklic, Lala, additional, Daien, Vincent, additional, Viola, Francesco, additional, Squirrell, David, additional, Lavid, Francisco Javier, additional, Creuzot-Garcher, Catherine, additional, Barthelmes, Daniel, additional, Gillies, Mark, additional, Miri, Admir, additional, Fung, Adrian, additional, Higueras, Alejandro, additional, Invernizzi, Alessandro, additional, Hamilton, Alex, additional, Cohn, Amy, additional, Vanderschueren, Ann, additional, Wolff, Benjamin, additional, Walid, Bougamha, additional, Hennings, Charles, additional, Chung, Charmaine, additional, Hornsby, Chris, additional, Rethati, Cinthia, additional, Villoria, Daniel Velazquez, additional, Chan, Derek, additional, Chong, Elaine, additional, Carreño, Ester, additional, Baudin, Florian, additional, Furness, Graham, additional, Michel, Guillaume, additional, Mack, Heather, additional, Steiner, Helen, additional, Mehta, Hemal, additional, Reddie, Ian, additional, Acton, James, additional, Wells, Jane, additional, Suarez, Joel, additional, Gilhotra, Jolly, additional, Oday, Justin, additional, Sararols, Laura, additional, Manning, Les, additional, Chow, Li Ping, additional, OToole, Louise, additional, Cordoves, Luis, additional, Arrazola, Maite, additional, Tena Sempere, María Eugenia, additional, Navarro, Maria Pilar, additional, Morgan, Mark, additional, Núñez, Marta Rodriguez, additional, Weber, Michel, additional, Marti, Miguel Castilla, additional, de la Fuente, Miguel, additional, Duran, Monica Asencio, additional, Muñoz, Pablo Catalán, additional, Carnota, Pablo, additional, Lockie, Patrick, additional, Beaumont, Paul, additional, Hinchcliffe, Peter, additional, Calvo, Pilar, additional, Barnes, Rachel, additional, Chalasani, Raj, additional, Barry, Richard, additional, Chong, Robert, additional, Gallego-Pinazo, Roberto, additional, Ferrier, Ross, additional, Fraser-Bell, Samantha, additional, Allieu, Sandrine, additional, Wickremasinghe, Sanjeev, additional, Tick, Sarah, additional, Welch, Sarah, additional, Gismero Moreno, Saturnino Manuel, additional, Nothling, Simon, additional, Aparicio-Sanchis, Sonia, additional, Young, Stephanie, additional, Wan, Sue, additional, Tan, Terence, additional, Kheir, Wajiha, additional, Valldeperas, Xavier, additional, Louw, Zanne, additional, and Bashshur, Ziad, additional

Published
2024
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17. Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning

Author

Wills, John W., Verma, Jatin R., Rees, Benjamin J., Harte, Danielle S. G., Haxhiraj, Qiellor, Barnes, Claire M., Barnes, Rachel, Rodrigues, Matthew A., Doan, Minh, Filby, Andrew, Hewitt, Rachel E., Thornton, Catherine A., Cronin, James G., Kenny, Julia D., Buckley, Ruby, Lynch, Anthony M., Carpenter, Anne E., Summers, Huw D., Johnson, George E., and Rees, Paul

Published
2021
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23. The role of peroneal nerve electrical neuromuscular stimulation in the augmentation of lower limb circulatory physiology in lower limb arterial and venous disease

Author

Barnes, Rachel and Chetter, Ian

Subjects
616.1, Medicine
Abstract

Introduction: Studies in healthy volunteers have demonstrated that peroneal nerve stimulation augments blood flow. The studies described within this thesis aimed to establish whether use of the geko™ neuromuscular stimulation device was effective and augments arterial venous and microcirculatory flow in patients with lower limb arterial and venous disease. The fibrinolytic and angiogenic activity of electrical stimulation within this cohort was also examined. Methods: Ethical approval was obtained for all aspects of the described studies. Participants with claudication, varicose veins or post- operative infrainguinal bypass grafts were assigned to receive either unilateral active stimulation or sham. Duplex assessments of arterial and venous volume flow were performed at baseline and following stimulation. Laser Doppler flowmetry measurements of microcirculatory flow were made continuously throughout the study period. ELISA analysis was undertaken of plasma samples drawn at baseline and following stimulation to determine the effect on vascular endothelial growth factor(VEGF), tissue plasminogen activator(t-PA) and plasminogen activator inhibitor 1(PAI-1). Results: The geko™ device was effective at producing visible muscle contraction in only 59% patients tested due to a combination of oedema and neuropathy. 77 participants were recruited in total to either a proof of concept study or the initial phase of a randomised trial: 30 claudicants (25 active, 5 control), 25 post infrainguinal bypass (19 active, 6 control) and 22 varicose veins (17 active, 5 control). Arterial volume flow increased significantly in all patient groups receiving active stimulation: claudicants 60 ml/ min(P<0.001); infra-inguinal bypass grafts 70ml/min(P<0.001) and varicose veins 80 ml/min(P<0.001). Venous volume flow significantly increased in all patient groups: claudicants 30 ml/min(P=0.001); infra-inguinal bypass grafts 30 ml/min(P=0.004) and varicose veins 80 ml/min(P<0.001). Microcirculatory flow increased in all patient groups: claudicants 22.2 flux units(P<0.001); infra-inguinal bypass grafts 21.8 flux units(P<0.001) and varicose veins 28.4 flux units(P<0.001). ELISA analysis demonstrated no statistically significant change in VEGF or t-PA antigen levels when comparing the active with the passive and control limbs. Peroneal nerve stimulation in the active limbs resulted in a significant decrease in PAI-1 of 34 ng/ml(P<0.001). Conclusion: Transcutaneous peroneal nerve stimulation with the geko™ device is potentially beneficial in patients with lower limb arterial and venous disease. This is primarily due to its ability to augment venous, arterial and microcirculatory flow. The results of this study were influential in the NICE guidance approving its use in vascular patients as a means of DVT prophylaxis. The enhanced fibrinolytic effect, by decreasing levels of PAI-1, warrants further investigation.

Published
2015

26. Military Mothers

Author

Barnes, Rachel, Stevelink, Sharon A. M., Dandeker, Christopher, Fear, Nicola T., MacDermid Wadsworth, Shelley, Series editor, Gewirtz, Abigail H., editor, and Youssef, Adriana M., editor

Published
2016
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27. THE DECADE AHEAD.

Author

Barnes, Rachel

Subjects
REAL estate sales, HOUSING
Abstract

Utah's population is projected to increase from 3.4 million in 2024 to almost 5.5 million by 2060, with Utah County being the epicenter of growth. The abundance of vacant land in Utah County is attracting people and driving real estate development. The Point, a 600-acre redevelopment project at Point of the Mountain, is seen as a model for smart growth and is expected to become an economic driver for the state. Growth in Salt Lake County is trending towards the west side, while the Northwest Quadrant inland port project area is predicted to boost real estate in Utah. The thriving e-commerce sector has allowed business owners to prioritize personal preferences over proximity to customers, benefiting less populated areas like Salt Lake City. [Extracted from the article]

Published
2024

29. Homicides of psychologists, physicians, nurses, pharmacists, social workers, and other health professionals: National Violent Death Reporting System data 2003–2020.

Author

Robiner, William N., Barnes, Rachel D., Freese, Rebecca L., Palmer, Brooke, and Kim, Michael H.

Subjects
*MEDICAL personnel, *SOCIAL workers, *VIOLENT deaths, *HOMICIDE rates, *PSYCHOLOGISTS, *PHARMACISTS, *NURSE-physician relationships, *VIOLENCE in the workplace
Abstract

Objective: Homicide is the extreme endpoint along the continuum of interpersonal violence. Violence in healthcare settings and directed toward healthcare workers has been a growing concern. Analysis of health professionals' homicides is needed to inform prevention interventions. Methods: Decedent numbers, age, and sex in the National Violent Death Reporting System are reported for 10 types of health professionals: advance practice registered nurses, dentists, nurses, pharmacists, physicians, physician assistants, psychiatrists, psychologists, social workers, and veterinarians. Results: Between 2003 and 2020, 944 homicides of these professionals were reported to the NVDRS. Nearly 80% of victims were women; 53% of homicides involved guns. Nurses, social workers, physicians, and pharmacists comprised the most victims. In 2020, nurses, social workers, pharmacists, and psychologists had the highest homicide rates relative to their workforce size. Few of these homicides were related to professionals' work. The number of homicides within these professions correlated highly with the size of professions' workforces. Conclusions: Health professionals' homicides constitute a small proportion of US homicides generally at lower rates than seen in the general population. Age is likely one of the protective factors. Future, more comprehensive data will provide greater insights into emerging trends to inform strategies to mitigate homicide risk in health professionals. Prevention needs to go beyond healthcare settings and address societal roots of violence. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Reply

Author

Shah, Janika, primary, Nguyen, Vuong, additional, Hunt, Adrian, additional, Mehta, Hemal, additional, Romero-Nuñez, Barbara, additional, Zarranz-Ventura, Javier, additional, Viola, Francesco, additional, Bougamha, Walid, additional, Barnes, Rachel, additional, Barthelmes, Daniel, additional, Gillies, Mark C., additional, and Fraser-Bell, Samantha, additional

Published
2023
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34. Reply

Author

Shah, Janika, Nguyen, Vuong, Hunt, Adrian, Mehta, Hemal, Romero-Nuñez, Barbara, Zarranz-Ventura, Javier, Viola, Francesco, Bougamha, Walid, Barnes, Rachel, Barthelmes, Daniel, Gillies, Mark C, Fraser-Bell, Samantha, and University of Zurich

Subjects
10018 Ophthalmology Clinic, 610 Medicine & health, 2725 Infectious Diseases, 2726 Microbiology (medical)
Published
2023

35. Eating Disorders In weight-related Therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behavioural weight management

Author

Jebeile, Hiba, primary, Lister, Natalie B., additional, Libesman, Sol, additional, Hunter, Kylie E., additional, McMaster, Caitlin M., additional, Johnson, Brittany J., additional, Baur, Louise A., additional, Paxton, Susan J., additional, Garnett, Sarah P., additional, Ahern, Amy L, additional, Wilfley, Denise E., additional, Maguire, Sarah, additional, Sainsbury, Amanda, additional, Steinbeck, Katharine, additional, Askie, Lisa, additional, Braet, Caroline, additional, Hill, Andrew J, additional, Nicholls, Dasha, additional, Jones, Rebecca A, additional, Dammery, Genevieve, additional, Grunseit, Alicia M., additional, Cooper, Kelly, additional, Kyle, Theodore K., additional, Newsome, Faith, additional, Quigley, Fiona, additional, Barnes, Rachel D., additional, Bean, Melanie K., additional, Beaulieu, Kristine, additional, Bonham, Maxine, additional, Boutelle, Kerri N., additional, Branco, Braulio Henrique Magnani, additional, Calugi, Simona, additional, Cardel, Michelle I., additional, Carpenter, Kelly, additional, Cheng, Hoi Lun, additional, Grave, Riccardo Dalle, additional, Danielsen, Yngvild S, additional, Demarzo, Marcelo, additional, Dordevic, Aimee, additional, Eichen, Dawn M., additional, Goldschmidt, Andrea B., additional, Hilbert, Anja, additional, Houben, Katrijn, additional, Lofrano do Prado, Mara, additional, Martin, Corby K., additional, McTiernan, Anne, additional, Mensinger, Janell L., additional, Pacanowski, Carly, additional, do Prado, Wagner Luiz, additional, Ramalho, Sofia M., additional, Raynor, Hollie A., additional, Rieger, Elizabeth, additional, Robinson, Eric, additional, Salvo, Vera, additional, Sherwood, Nancy E., additional, Simpson, Sharon A., additional, Skjakodegard, Hanna F., additional, Smith, Evelyn, additional, Partridge, Stephanie, additional, Tanofsky-Kraff, Marian, additional, Taylor, Rachael W., additional, Van Eyck, Annelies, additional, Varady, Krista A., additional, Vidmar, Alaina P., additional, Whitelock, Victoria, additional, Yanovski, Jack, additional, and Seidler, Anna L., additional

Published
2022
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36. Delivery features and intervention strategies of trials in the Eating Disorders in weight-related Therapy (EDIT) Collaboration: intervention coding protocol

Author

Yanovski, Jack A., Prado, Wagner, Skjakodegard, Hanna F., Demarzo, Marcelo, Braet, Caroline, McMaster, Caitlin M., Dammery, Genevieve, Jacqlyn Yourell, McTiernan, Anne, Cheng, Hoi Lun, Taylor, Rachael W., Grave, Riccardo Dalle, Grunseit, Alicia M., Pryde, Samantha, Raynor, Hollie A., Jebeile, Hiba, Darling, Katherine, Varady, Krista A., Paxton, Susan J., Hunter, Kylie E., Baur, Louise A., Pacanowski, Carly, Hilbert, Anja, Mensinger, Janell L., Bonham, Maxine P., Seidler, Anna Lene, Maguire, Sarah, Barnes, Rachel D., Robinson, Eric, Boutelle, Kerri N., Steinbeck, Katherine, Askie, Lisa, Whitelock, Victoria, Dasha Nicholls, Prado, Mara Lofrano Do, Quigley, Fiona, Bean, Melanie K., Vidmar, Alaina P., Carpenter, Kelly, Dordevic, Aimee, Smith, Evelyn, Khalid, Rabia, Cooper, Kelly, Wilfley, Denise E., Branco, Braulio Henrique Magnani, Ramalho, Sofia M., Jelalian, Elissa, Tanofsky-Kraff, Marian, Calugi, Simona, Sainsbury, Amanda, Rhee, Kyung E., Kyle, Theodore K., Beaulieu, Kristine, Rieger, Elizabeth, Simpson, Sharon A., Danielsen, Yngvild S., Van Eyck, Annelies, Gross, Amy, Salvo, Vera, Piya, Milan, Johnson, Brittany J, Goldschmidt, Andrea B., Eichen, Dawn M., Heeren, Faith N., Partridge, Stephanie R., Garnett, Sarah P., Jones, Rebecca A., Lister, Natalie B., Hill, Andrew J., Corby K. Martin, and Ahern, Amy L.

Published
2023
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42. Characterization of Poor Visual Outcomes of Diabetic Macular Edema: The Fight Retinal Blindness! Project

Author

Shah, Janika, Nguyen, Vuong, Hunt, Adrian, Mehta, Hemal, Romero-Nuñez, Barbara, Zarranz-Ventura, Javier, Viola, Francesco, Bougamha, Walid, Barnes, Rachel, Barthelmes, Daniel, Gillies, Mark C, Fraser-Bell, Samantha, University of Zurich, and Shah, Janika

Subjects
Vascular Endothelial Growth Factor A, 10018 Ophthalmology Clinic, Diabetic Retinopathy, Settore MED/30 - Malattie Apparato Visivo, Anti-VEGF, Vision Disorders, Angiogenesis Inhibitors, 610 Medicine & health, Diabetic macular edema, Diabetic retinopathy, Intravitreal steroids, Blindness, 2731 Ophthalmology, Macular Edema, Bevacizumab, Ophthalmology, Receptors, Vascular Endothelial Growth Factor, Ranibizumab, Intravitreal Injections, Diabetes Mellitus, Humans
Abstract

To investigate the incidence, characteristics, and baseline predictors of poor visual outcomes in eyes with diabetic macular edema (DME) receiving intravitreal therapy in routine clinical practice.Observational study.Treatment-naïve eyes starting intravitreal therapy for DME between 2014 and 2018 tracked in the Fight Retinal Blindness! registry. We examined 2 groups with poor visual outcomes: (1) those with sustained vision loss of10 letters from baseline without recovery of visual acuity (VA); and (2) those with a VA of 55 letters at 2 years. Respective controls were eyes that did not experience poor visual outcomes.Kaplan-Meier curves analyzed the proportion of eyes that experienced poor outcomes. Cox proportional hazards models evaluated the potential baseline predictors of poor outcomes.The proportion of eyes that experienced poor visual outcomes within 2 years of treatment initiation and its baseline predictors.The proportion of eyes with sustained VA of ≥ 10 letter loss was 14% at 2 years; 16% of eyes had VA of ≤ 55 letters 2 years after starting intravitreal therapy. Initial treatment with intravitreal corticosteroid was independently associated with a higher incidence of ≥ 10 letter loss (hazard ratio [HR], 3.21; 95% confidence interval [CI], 1.60-6.44; P 0.01). No improvement in the VA at 3 months after starting treatment was associated with ≥ 10 letter loss (HR, 6.81; 95% CI, 4.11-11.27; P 0.01) and VA of ≤ 55 letters at 2 years (HR, 4.28; 95% CI, 2.66-6.89; P 0.01). The other factors related to higher risk of VA of ≤ 55 letters were older age (HR, 1.02 per year; 95% CI, 1-1.04; P = 0.04) and poor baseline VA (HR, 0.68 per 5 letters; 95% CI, 0.65-0.72, P 0.001).Fourteen percent of eyes managed with intravitreal therapy in routine clinical care experienced ≥ 10 letter loss and 16% had VA of ≤55 letters 2 years after starting the treatment for DME. The identification of the incidence and predictors of poor outcomes provides a more accurate assessment of the potential benefit from intravitreal therapy.

Published
2022

44. Characterization of Poor Visual Outcomes of Diabetic Macular Edema: The Fight Retinal Blindness! Project

Author

Shah, Janika, primary, Nguyen, Vuong, additional, Hunt, Adrian, additional, Mehta, Hemal, additional, Romero-Nuñez, Barbara, additional, Zarranz-Ventura, Javier, additional, Viola, Francesco, additional, Bougamha, Walid, additional, Barnes, Rachel, additional, Barthelmes, Daniel, additional, Gillies, Mark C., additional, and Fraser-Bell, Samantha, additional

Published
2022
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