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1,367 results on '"Barnes, B."'

1. Kink Collision in the Noncanonical $\varphi^{6}$ Model: A Model with Localized Inner Structures

Author

Takyi, I., Gyampoh, S., Barnes, B., Ackora-Prah, J., and Okyere, G. A.

Subjects
High Energy Physics - Theory
Abstract

We study collisions of kinks in the one-space and one-time dimensional noncanonical nonintegrable scalar $\phi^{6}$ model. We examine the energy density of the kink, and we find that, as a function of the parameters that control the curvature of the potential, a localized inner structure of the energy density emerges. We also examine the kink excitation spectrum and the dynamics of the kink collisions for a wide range of initial velocities. We find that apart from the resonance windows, the production of two to three oscillons occurs for some values of the principal parameters of the model., Comment: 9pages, 19figures

Published
2022
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2. Scattering of Kinks in Noncanonical sine-Gordon Model

Author

Takyi, I., Barnes, B., Tornyeviadzi, H. M., and Ackora-Prah, J.

Subjects
High Energy Physics - Theory, Nonlinear Sciences - Pattern Formation and Solitons
Abstract

In this paper, we numerically study the scattering of kinks in the noncanonical sine-Gordon model using Fourier spectral methods. The model depends on two free parameters, which control the localized inner structure in the energy density and the characteristics of the scattering potential. It has been conjectured that the kink solutions in the noncanonical model possess inner structures in their energy density, and the presence of these yields bound states and resonance structures for some relative velocities between the kink and the antikink. In the numerical study, we observed that the classical kink mass decreases monotonically as the free parameters vary, and yields bion-formations and long-lived oscillations in the scattering of the kink-antikink system., Comment: 11 pages, 22 figures

Published
2021
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3. Vacuum Polarization Energy of the Kinks in the Sinh-Deformed Models

Author

Takyi, I., Barnes, B., and Ackora-Prah, J.

Subjects
High Energy Physics - Theory
Abstract

We compute the one-loop quantum corrections to the kink energies of the sinh-deformed $\phi^{4}$ and $\varphi^{6}$ models in one space and one time dimensions. These models are constructed from the well-known polynomial $\phi^{4}$ and $\varphi^{6}$ models by a deformation procedure. We also compute the vacuum polarization energy to the non-polynomial function $U(\phi)=\frac{1}{4}(1-\sinh^{2}\phi)^{2}$. This potential approaches the $\phi^{4}$ model in the limit of small values of the scalar function. These energies are extracted from scattering data for fluctuations about the kink solutions. We show that for certain topological sectors with non-equivalent vacua the kink solutions of the sinh-deformed models are destabilized., Comment: 12 pages, 8 figures, 4 tables

Published
2020

4. Dead clades walking are a pervasive macroevolutionary pattern

Author

Barnes, B Davis, Sclafani, Judith A, and Zaffos, Andrew

Subjects
Biological Sciences, Ecology, Evolutionary Biology, Earth Sciences, Geology, Life Below Water, Animals, Aquatic Organisms, Biodiversity, Evolution, Molecular, Fossils, Invertebrates, Phylogeny, mass extinction, recovery, biodiversity, macroevolution
Abstract

D. Jablonski [Proc. Natl. Acad. Sci. U.S.A. 99, 8139-8144 (2002)] coined the term "dead clades walking" (DCWs) to describe marine fossil orders that experience significant drops in genus richness during mass extinction events and never rediversify to previous levels. This phenomenon is generally interpreted as further evidence that the macroevolutionary consequences of mass extinctions can continue well past the formal boundary. It is unclear, however, exactly how long DCWs are expected to persist after extinction events and to what degree they impact broader trends in Phanerozoic biodiversity. Here we analyze the fossil occurrences of 134 skeletonized marine invertebrate orders in the Paleobiology Database (paleobiodb.org) using a Bayesian method to identify significant change points in genus richness. Our analysis identifies 70 orders that experience major diversity losses without recovery. Most of these taxa, however, do not fit the popular conception of DCWs as clades that narrowly survive a mass extinction event and linger for only a few stages before succumbing to extinction. The median postdrop duration of these DCW orders is long (>30 Myr), suggesting that previous studies may have underestimated the long-term taxonomic impact of mass extinction events. More importantly, many drops in diversity without recovery are not associated with mass extinction events and occur during background extinction stages. The prevalence of DCW orders throughout both mass and background extinction intervals and across phyla (>50% of all marine invertebrate orders) suggests that the DCW pattern is a major component of macroevolutionary turnover.

Published
2021

7. Change in Patient Reported Respiratory Symptoms in a Randomized, Double-blind, Trial of Amikacin Liposome Inhalation Suspension in Adults With Newly Diagnosed or Recurrent Mycobacterium Avium Complex Lung Disease: The ARISE Study

Author

Daley, C.L., primary, Serrano, D., additional, McManus, S., additional, Podger, L., additional, Barnes, B., additional, Hassan, M., additional, Nevoret, M.-L., additional, Yuen, D.W., additional, Ciesielska, M., additional, and Mange, K.C., additional

Published
2024
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10. Konzept zur Schaffung einer Plattform zur bundesweiten Auswertung von klinischen Krebsregisterdaten für Forschungsfragen und registerbasierten Studien (Plato2)

Author

Zeissig, S, Klinkhammer-Schalke, M, Barnes, B, Bruns, J, Franke, B, Hartz, T, Hennings, A, Kerek-Bodden, H, Krause, JK, Kraywinkel, K, Nettekoven, G, Ortmann, O, Seufferlein, T, Weitmann, K, Wesselmann, S, Benz, SR, Zeissig, S, Klinkhammer-Schalke, M, Barnes, B, Bruns, J, Franke, B, Hartz, T, Hennings, A, Kerek-Bodden, H, Krause, JK, Kraywinkel, K, Nettekoven, G, Ortmann, O, Seufferlein, T, Weitmann, K, Wesselmann, S, and Benz, SR

Published
2024

12. 127P REGN5668 (MUC16xCD28 bispecific antibody) with cemiplimab (anti-PD-1 antibody) in recurrent ovarian cancer: Phase I dose-escalation study

Author

Winer, I.S., primary, O'Cearbhaill, R.E., additional, Bouberhan, S., additional, Hays, J.L., additional, Wenham, R.M., additional, Roque, D.R., additional, Yeku, O.O., additional, Liu, J.F., additional, Wang, B., additional, Yoo, S-Y., additional, Govindraj, S., additional, Zhu, M., additional, Brouwer-Visser, J., additional, Peterman, M.J., additional, Barnes, B., additional, Lowy, I., additional, Knorr, D., additional, Uldrick, T.S., additional, and Miller, E.A., additional

Published
2023
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13. Commissioning Status of the Linac for the Facility for Rare Isotope Beams

Author

Lidia, S., Ao, H., Barnes, B., Bennett, R., Bernal-Ruiz, E., Bollen, G., Brandon, J., Bull, B., Bultman, N., Casagrande, F., Chabot, D., Cogan, S., Compton, C., Davidson, K., Daykin, E., Georgiobani, D., Gibson, P., Grender, I., Kim, S.-H., Hartung, W., Hausmann, M., Hodges, L., Holland, K., Hussain, A., Ikegami, M., Konrad, M., Kiupel, G., Larter, T., Li, Z., Malloch, I., Machicoane, G., Maniar, H., Manwiller, P., Martins, B., Maruta, T., Morris, D., Morrison, P., Morton, C., Nesterenko, I., Omitto, D., Ostroumov, P., Pellemoine, F., Plastun, A., Popielarski, J., Popielarski, L., Pozdeyev, E., Ren, H., Rodriguez, P., Rodriguez, S., Russo, T., Saito, K., Shane, R., Stanley, S., Stolz, A., Timko, G., Wei, J., Xu, M., Xu, T., Yamazaki, Y., Yashimoto, T., Zhao, Q., and Zhao, S.

Published
2020
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18. A vector control and data acquisition system for the multicavity LLRF system for cryomodule1 at Fermilab

Author

Varghese, P., Chase, B., Barnes, B., Branlard, J., Cullerton, E., Joireman, P., and Tupikov, V.

Subjects
Physics - Accelerator Physics, Physics - Instrumentation and Detectors
Abstract

A LLRF control and data acquisition system for the 8-cavity cryomodule1 at the ILCTA has been implemented using three 33-channel ADC boards in a VXI mainframe. One card each is dedicated to the cavity probes for vector control, forward power and reverse power measurements. The system is scalable to 24 cavities or more with the commissioning of cryomodules 2 and 3 without additional hardware. The signal processing and vector control of the cavities is implemented in an FPGA and a high speed data acquisition system with up to 100 channels which stores data in external SDRAM memory. The system supports both pulsed and CW modes with a pulse rate of 5 Hz. Acquired data is transferred between pulses to auxiliary systems such as the piezo controller through the VXI slot0 controller. The performance of the vector control system is evaluated and the design of the system is described., Comment: 4 pp

Published
2012

19. INFLUENCE BY DESIGN.

Author

BARNES, B. KIM

Subjects
*TECHNOLOGICAL innovations, *PERSONAL space, *NUDGE theory, *DEPOSIT insurance, *ORGANIZATIONAL change
Abstract

This article discusses the importance of influence skills and how they can be used to achieve personal and professional goals. It explains that influence can be exerted through various means, such as face-to-face interactions, media, and written materials. However, the effectiveness of influence depends on factors like trust, expertise, and shared values. The article also explores the concept of "nudging" and how it can be used to design environments and choices that guide people towards desired actions. It emphasizes the ethical nature of influence and distinguishes it from manipulation. The article concludes by outlining a six-step process for creating an environment that encourages positive actions and gaining support for implementing solutions. [Extracted from the article]

Published
2024

21. Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification

Author

Liu, L., Toung, J.M., Jassowicz, A.F., Vijayaraghavan, R., Kang, H., Zhang, R., Kruglyak, K.M., Huang, H.J., Hinoue, T., Shen, H., Salathia, N.S., Hong, D.S., Naing, A., Subbiah, V., Piha-Paul, S.A., Bibikova, M., Granger, G., Barnes, B., Shen, R., Gutekunst, K., Fu, S., Tsimberidou, A.M., Lu, C., Eng, C., Moulder, S.L., Kopetz, E.S., Amaria, R.N., Meric-Bernstam, F., Laird, P.W., Fan, J.-B., and Janku, F.

Published
2018
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26. Using Behavior Change to Reduce Child Lead Exposure in Resource-Poor Settings: A Formative Study

Author

Feit, M. N., Mathee, A., Harpham, T., and Barnes, B. R.

Abstract

The objective of this formative research was to explore the acceptability and feasibility of changing housekeeping behaviors as a low-cost approach that may reduce childhood lead exposure in Johannesburg, South Africa. Using the Trials of Improved Practices (TIPs) methodology, modified housekeeping behaviors were negotiated with participants who chose the behaviors they wanted to try and then performed them in their homes over 4 weeks. Researchers interviewed them at the end of the month to understand their experience of trying out the behaviors. The modified behaviors offered to each participant were as follows: cleaning window sills with detergent and water, cleaning window sills more frequently, mopping floors with two buckets (one with soapy water for washing and one with clean water for rinsing), mopping floors more frequently, dusting surfaces with detergent and water and dusting surfaces more frequently. Participants found cleaning window sills with soap and water and cleaning them more often the most acceptable and feasible of behavior modifications. Environmental samples showed a significant reduction in lead dust on window sills. These findings can assist in the development of acceptable and feasible medium-term interventions to reduce childhood lead exposure in resource-poor settings until more robust health policies are implemented.

Published
2014
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30. Overview of Fragment Separator Superconducting Magnets in the Facility for Rare Isotope Beams

Author

Choi, Y., primary, Al-Mahmoud, Y., additional, Asciutto, J., additional, Barnes, B., additional, Bliton, R., additional, Compton, C., additional, Chang, W., additional, Du, X., additional, Greene, D. B., additional, Holland, K., additional, Magsig, C., additional, Miller, S., additional, Nguyen, H., additional, Nguyen, L., additional, Popielarski, L., additional, Portillo, M., additional, Reaume, M., additional, Saito, K., additional, Tousignant, B., additional, Walker, R., additional, Wenstrom, J., additional, and Xu, T., additional

Published
2023
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34. A concentric circles view of health data relations facilitates understanding of sociotechnical challenges for learning health systems and the role of federated data networks

Author

Milne, R, Sheehan, M, Barnes, B, Kapper, J, Lea, N, N'Dow, J, Singh, G, Martín-Uranga, A, and Hughes, N

Subjects
Federated data access, Ethics, Data, federated data access, trust, Trust, ethics, Distributed data access, Consent, data, Artificial Intelligence, Computer Science (miscellaneous), consent, distributed data access, Information Systems
Abstract

The ability to use clinical and research data at scale is central to hopes for data-driven medicine. However, in using such data researchers often encounter hurdles–both technical, such as differing data security requirements, and social, such as the terms of informed consent, legal requirements and patient and public trust. Federated or distributed data networks have been proposed and adopted in response to these hurdles. However, to date there has been little consideration of how FDNs respond to both technical and social constraints on data use. In this Perspective we propose an approach to thinking about data in terms that make it easier to navigate the health data space and understand the value of differing approaches to data collection, storage and sharing. We set out a socio-technical model of data systems that we call the “Concentric Circles View” (CCV) of data-relationships. The aim is to enable a consistent understanding of the fit between the local relationships within which data are produced and the extended socio-technical systems that enable their use. The paper suggests this model can help understand and tackle challenges associated with the use of real-world data in the health setting. We use the model to understand not only how but why federated networks may be well placed to address emerging issues and adapt to the evolving needs of health research for patient benefit. We conclude that the CCV provides a useful model with broader application in mapping, understanding, and tackling the major challenges associated with using real world data in the health setting.

Published
2022
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35. 575P Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade serous or endometrioid ovarian cancer: A multi-national observational study

Author

Morgan, R.D., primary, Clamp, A.R., additional, Barnes, B., additional, Schlecht, H., additional, Yarram-Smith, L., additional, Wallis, Y., additional, Morgan, S., additional, Valganon, M., additional, Hudson, E., additional, McKenna, S., additional, Sundar, S., additional, Nicum, S., additional, Brenton, J.D., additional, Kristeleit, R., additional, Banerjee, S., additional, McNeish, I., additional, Ledermann, J.A., additional, Taylor, S., additional, Evans, G., additional, and Jayson, G.C., additional

Published
2022
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47. Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry

Author

Barbaro, R, Maclaren, G, Boonstra, P, Iwashyna, T, Slutsky, A, Fan, E, Bartlett, R, Tonna, J, Hyslop, R, Fanning, J, Rycus, P, Hyer, S, Anders, M, Agerstrand, C, Hryniewicz, K, Diaz, R, Lorusso, R, Combes, A, Brodie, D, Alexander, P, Barrett, N, Belohlavek, J, Fisher, D, Fraser, J, Hssain, A, Jung, J, Mcmullan, M, Mehta, Y, Ogino, M, Paden, M, Shekar, K, Stead, C, Abu-Omar, Y, Agnoletti, V, Akbar, A, Alfoudri, H, Alviar, C, Aronsky, V, August, E, Auzinger, G, Aveja, H, Bakken, R, Balcells, J, Bangalore, S, Barnes, B, Bautista, A, Bellows, L, Beltran, F, Benharash, P, Benni, M, Berg, J, Bertini, P, Blanco-Schweizer, P, Brunsvold, M, Budd, J, Camp, D, Caridi-Scheible, M, Carton, E, Casanova-Ghosh, E, Castleberry, A, Chipongian, C, Choi, C, Circelli, A, Cohen, E, Collins, M, Copus, S, Coy, J, Crist, B, Cruz, L, Czuczwar, M, Daneshmand, M, Davis II, D, De la Cruz, K, Devers, C, Duculan, T, Durham, L, Elapavaluru, S, Elzo Kraemer, C, Filho, E, Fitzgerald, J, Foti, G, Fox, M, Fritschen, D, Fullerton, D, Gelandt, E, Gerle, S, Giani, M, Goh, S, Govener, S, Grone, J, Guber, M, Gudzenko, V, Gutteridge, D, Guy, J, Haft, J, Hall, C, Hassan, I, Herran, R, Hirose, H, Ibrahim, A, Igielski, D, Ivascu, F, Izquierdo Blasco, J, Jackson, J, Jain, H, Jaiswal, B, Johnson, A, Jurynec, J, Kellter, N, Kohl, A, Kon, Z, Kredel, M, Kriska, K, Kunavarapu, C, Lansink-Hartgring, O, Larocque, J, Larson, S, Layne, T, Ledot, S, Lena, N, Lillie, J, Lotz, G, Lucas, M, Ludwigson, L, Maas, J, Maertens, J, Mast, D, Mccardle, S, Mcdonald, B, Mclarty, A, Mcmahon, C, Meybohm, P, Meyns, B, Miller, C, Moraes Neto, F, Morris, K, Muellenbach, R, Nicholson, M, O'Brien, S, O'Keefe, K, Ogston, T, Oldenburg, G, Oliveira, F, Oppel, E, Pardo, D, Parker, S, Pedersen, F, Pellecchia, C, Pelligrini, J, Pham, T, Phillips, A, Pirani, T, Piwowarczyk, P, Plambeck, R, Pruett, W, Quandt, B, Ramanathan, K, Rey, A, Reyher, C, Riera del Brio, J, Roberts, R, Roe, D, Roeleveld, P, Rudy, J, Rueda, L, Russo, E, Sanchez Ballesteros, J, Satou, N, Saueressig, M, Saunders, P, Schlotterbeck, M, Schwarz, P, Scriven, N, Serra, A, Shamsah, M, Sim, L, Smart, A, Smith, A, Smith, D, Smith, M, Sodha, N, Sonntagbauer, M, Sorenson, M, Stallkamp, E, Stewart, A, Swartz, K, Takeda, K, Thompson, S, Toy, B, Tuazon, D, Uchiyama, M, Udeozo, O, van Poppel, S, Ventetuolo, C, Vercaemst, L, Vinh Chau, N, Wang, I, Williamson, C, Wilson, B, Winkels, H, Barbaro R. P., MacLaren G., Boonstra P. S., Iwashyna T. J., Slutsky A. S., Fan E., Bartlett R. H., Tonna J. E., Hyslop R., Fanning J. J., Rycus P. T., Hyer S. J., Anders M. M., Agerstrand C. L., Hryniewicz K., Diaz R., Lorusso R., Combes A., Brodie D., Alexander P., Barrett N., Belohlavek J., Fisher D., Fraser J., Hssain A. A., Jung J. S., McMullan M., Mehta Y., Ogino M. T., Paden M. L., Shekar K., Stead C., Abu-Omar Y., Agnoletti V., Akbar A., Alfoudri H., Alviar C., Aronsky V., August E., Auzinger G., Aveja H., Bakken R., Balcells J., Bangalore S., Barnes B. W., Bautista A., Bellows L. L., Beltran F., Benharash P., Benni M., Berg J., Bertini P., Blanco-Schweizer P., Brunsvold M., Budd J., Camp D., Caridi-Scheible M., Carton E., Casanova-Ghosh E., Castleberry A., Chipongian C. T., Choi C. W., Circelli A., Cohen E., Collins M., Copus S., Coy J., Crist B., Cruz L., Czuczwar M., Daneshmand M., Davis II D., De la Cruz K., Devers C., Duculan T., Durham L., Elapavaluru S., Elzo Kraemer C. V., Filho E. C., Fitzgerald J., Foti G., Fox M., Fritschen D., Fullerton D., Gelandt E., Gerle S., Giani M., Goh S. G., Govener S., Grone J., Guber M., Gudzenko V., Gutteridge D., Guy J., Haft J., Hall C., Hassan I. F., Herran R., Hirose H., Ibrahim A. S., Igielski D., Ivascu F. A., Izquierdo Blasco J., Jackson J., Jain H., Jaiswal B., Johnson A. C., Jurynec J. A., Kellter N. M., Kohl A., Kon Z., Kredel M., Kriska K., Kunavarapu C., Lansink-Hartgring O., LaRocque J., Larson S. B., Layne T., Ledot S., Lena N., Lillie J., Lotz G., Lucas M., Ludwigson L., Maas J. J., Maertens J., Mast D., McCardle S., McDonald B., McLarty A., McMahon C., Meybohm P., Meyns B., Miller C., Moraes Neto F., Morris K., Muellenbach R., Nicholson M., O'Brien S., O'Keefe K., Ogston T., Oldenburg G., Oliveira F. M., Oppel E., Pardo D., Parker S. J., Pedersen F. M., Pellecchia C., Pelligrini J. A. S., Pham T. T. N., Phillips A. R., Pirani T., Piwowarczyk P., Plambeck R., Pruett W., Quandt B., Ramanathan K., Rey A., Reyher C., Riera del Brio J., Roberts R., Roe D., Roeleveld P. P., Rudy J., Rueda L. F., Russo E., Sanchez Ballesteros J., Satou N., Saueressig M. G., Saunders P. C., Schlotterbeck M., Schwarz P., Scriven N., Serra A., Shamsah M., Sim L., Smart A., Smith A., Smith D., Smith M., Sodha N., Sonntagbauer M., Sorenson M., Stallkamp E. B., Stewart A., Swartz K., Takeda K., Thompson S., Toy B., Tuazon D., Uchiyama M., Udeozo O. I., van Poppel S., Ventetuolo C., Vercaemst L., Vinh Chau N. V., Wang I. -W., Williamson C., Wilson B., Winkels H., Barbaro, R, Maclaren, G, Boonstra, P, Iwashyna, T, Slutsky, A, Fan, E, Bartlett, R, Tonna, J, Hyslop, R, Fanning, J, Rycus, P, Hyer, S, Anders, M, Agerstrand, C, Hryniewicz, K, Diaz, R, Lorusso, R, Combes, A, Brodie, D, Alexander, P, Barrett, N, Belohlavek, J, Fisher, D, Fraser, J, Hssain, A, Jung, J, Mcmullan, M, Mehta, Y, Ogino, M, Paden, M, Shekar, K, Stead, C, Abu-Omar, Y, Agnoletti, V, Akbar, A, Alfoudri, H, Alviar, C, Aronsky, V, August, E, Auzinger, G, Aveja, H, Bakken, R, Balcells, J, Bangalore, S, Barnes, B, Bautista, A, Bellows, L, Beltran, F, Benharash, P, Benni, M, Berg, J, Bertini, P, Blanco-Schweizer, P, Brunsvold, M, Budd, J, Camp, D, Caridi-Scheible, M, Carton, E, Casanova-Ghosh, E, Castleberry, A, Chipongian, C, Choi, C, Circelli, A, Cohen, E, Collins, M, Copus, S, Coy, J, Crist, B, Cruz, L, Czuczwar, M, Daneshmand, M, Davis II, D, De la Cruz, K, Devers, C, Duculan, T, Durham, L, Elapavaluru, S, Elzo Kraemer, C, Filho, E, Fitzgerald, J, Foti, G, Fox, M, Fritschen, D, Fullerton, D, Gelandt, E, Gerle, S, Giani, M, Goh, S, Govener, S, Grone, J, Guber, M, Gudzenko, V, Gutteridge, D, Guy, J, Haft, J, Hall, C, Hassan, I, Herran, R, Hirose, H, Ibrahim, A, Igielski, D, Ivascu, F, Izquierdo Blasco, J, Jackson, J, Jain, H, Jaiswal, B, Johnson, A, Jurynec, J, Kellter, N, Kohl, A, Kon, Z, Kredel, M, Kriska, K, Kunavarapu, C, Lansink-Hartgring, O, Larocque, J, Larson, S, Layne, T, Ledot, S, Lena, N, Lillie, J, Lotz, G, Lucas, M, Ludwigson, L, Maas, J, Maertens, J, Mast, D, Mccardle, S, Mcdonald, B, Mclarty, A, Mcmahon, C, Meybohm, P, Meyns, B, Miller, C, Moraes Neto, F, Morris, K, Muellenbach, R, Nicholson, M, O'Brien, S, O'Keefe, K, Ogston, T, Oldenburg, G, Oliveira, F, Oppel, E, Pardo, D, Parker, S, Pedersen, F, Pellecchia, C, Pelligrini, J, Pham, T, Phillips, A, Pirani, T, Piwowarczyk, P, Plambeck, R, Pruett, W, Quandt, B, Ramanathan, K, Rey, A, Reyher, C, Riera del Brio, J, Roberts, R, Roe, D, Roeleveld, P, Rudy, J, Rueda, L, Russo, E, Sanchez Ballesteros, J, Satou, N, Saueressig, M, Saunders, P, Schlotterbeck, M, Schwarz, P, Scriven, N, Serra, A, Shamsah, M, Sim, L, Smart, A, Smith, A, Smith, D, Smith, M, Sodha, N, Sonntagbauer, M, Sorenson, M, Stallkamp, E, Stewart, A, Swartz, K, Takeda, K, Thompson, S, Toy, B, Tuazon, D, Uchiyama, M, Udeozo, O, van Poppel, S, Ventetuolo, C, Vercaemst, L, Vinh Chau, N, Wang, I, Williamson, C, Wilson, B, Winkels, H, Barbaro R. P., MacLaren G., Boonstra P. S., Iwashyna T. J., Slutsky A. S., Fan E., Bartlett R. H., Tonna J. E., Hyslop R., Fanning J. J., Rycus P. T., Hyer S. J., Anders M. M., Agerstrand C. L., Hryniewicz K., Diaz R., Lorusso R., Combes A., Brodie D., Alexander P., Barrett N., Belohlavek J., Fisher D., Fraser J., Hssain A. A., Jung J. S., McMullan M., Mehta Y., Ogino M. T., Paden M. L., Shekar K., Stead C., Abu-Omar Y., Agnoletti V., Akbar A., Alfoudri H., Alviar C., Aronsky V., August E., Auzinger G., Aveja H., Bakken R., Balcells J., Bangalore S., Barnes B. W., Bautista A., Bellows L. L., Beltran F., Benharash P., Benni M., Berg J., Bertini P., Blanco-Schweizer P., Brunsvold M., Budd J., Camp D., Caridi-Scheible M., Carton E., Casanova-Ghosh E., Castleberry A., Chipongian C. T., Choi C. W., Circelli A., Cohen E., Collins M., Copus S., Coy J., Crist B., Cruz L., Czuczwar M., Daneshmand M., Davis II D., De la Cruz K., Devers C., Duculan T., Durham L., Elapavaluru S., Elzo Kraemer C. V., Filho E. C., Fitzgerald J., Foti G., Fox M., Fritschen D., Fullerton D., Gelandt E., Gerle S., Giani M., Goh S. G., Govener S., Grone J., Guber M., Gudzenko V., Gutteridge D., Guy J., Haft J., Hall C., Hassan I. F., Herran R., Hirose H., Ibrahim A. S., Igielski D., Ivascu F. A., Izquierdo Blasco J., Jackson J., Jain H., Jaiswal B., Johnson A. C., Jurynec J. A., Kellter N. M., Kohl A., Kon Z., Kredel M., Kriska K., Kunavarapu C., Lansink-Hartgring O., LaRocque J., Larson S. B., Layne T., Ledot S., Lena N., Lillie J., Lotz G., Lucas M., Ludwigson L., Maas J. J., Maertens J., Mast D., McCardle S., McDonald B., McLarty A., McMahon C., Meybohm P., Meyns B., Miller C., Moraes Neto F., Morris K., Muellenbach R., Nicholson M., O'Brien S., O'Keefe K., Ogston T., Oldenburg G., Oliveira F. M., Oppel E., Pardo D., Parker S. J., Pedersen F. M., Pellecchia C., Pelligrini J. A. S., Pham T. T. N., Phillips A. 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Abstract

Background: Multiple major health organisations recommend the use of extracorporeal membrane oxygenation (ECMO) support for COVID-19-related acute hypoxaemic respiratory failure. However, initial reports of ECMO use in patients with COVID-19 described very high mortality and there have been no large, international cohort studies of ECMO for COVID-19 reported to date. Methods: We used data from the Extracorporeal Life Support Organization (ELSO) Registry to characterise the epidemiology, hospital course, and outcomes of patients aged 16 years or older with confirmed COVID-19 who had ECMO support initiated between Jan 16 and May 1, 2020, at 213 hospitals in 36 countries. The primary outcome was in-hospital death in a time-to-event analysis assessed at 90 days after ECMO initiation. We applied a multivariable Cox model to examine whether patient and hospital factors were associated with in-hospital mortality. Findings: Data for 1035 patients with COVID-19 who received ECMO support were included in this study. Of these, 67 (6%) remained hospitalised, 311 (30%) were discharged home or to an acute rehabilitation centre, 101 (10%) were discharged to a long-term acute care centre or unspecified location, 176 (17%) were discharged to another hospital, and 380 (37%) died. The estimated cumulative incidence of in-hospital mortality 90 days after the initiation of ECMO was 37·4% (95% CI 34·4–40·4). Mortality was 39% (380 of 968) in patients with a final disposition of death or hospital discharge. The use of ECMO for circulatory support was independently associated with higher in-hospital mortality (hazard ratio 1·89, 95% CI 1·20–2·97). In the subset of patients with COVID-19 receiving respiratory (venovenous) ECMO and characterised as having acute respiratory distress syndrome, the estimated cumulative incidence of in-hospital mortality 90 days after the initiation of ECMO was 38·0% (95% CI 34·6–41·5). Interpretation: In patients with COVID-19 who received ECMO, both estimated

Published
2020

50. The Impact of Re-Using Hypodermic Needles

Author

Barnes, B., Gani, J., Price, Camille C., Series Editor, Zhu, Joe, Advisory Editor, Hillier, Frederick S., Editor-in-chief, Dror, Moshe, editor, L’Ecuyer, Pierre, editor, and Szidarovszky, Ferenc, editor

Published
2002
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