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Vinicius Tieppo Francio,1 David Sherwood,2 Eric Twohey,3 Brandon Barndt,4 Robert Pagan-Rosado,5 James Eubanks,6 Dawood Sayed7 1Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City, KS, USA; 2Department of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA; 3Gundersen Health System Transitional, La Crosse, WI, USA; 4Department of Physical Medicine and Rehabilitation, Temple University and Moss Rehabilitation, Philadelphia, PA, USA; 5Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA; 6Department of Physical Medicine and Rehabilitation, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 7Department of Anesthesiology, The University of Kansas Medical Center, Kansas City, KS, USACorrespondence: Dawood SayedDepartment of Anesthesiology, The University of Kansas Medical Center, 3901 Rainbow Blvd, Mailstop 1034, Kansas City, KS, 66103, USATel +1 913-588-5521Fax +1 913-588-3365Email dsayed@kumc.eduAbstract: Historically, intervertebral disc degeneration has been the etiological target of chronic low back pain; however, disc degeneration is not necessarily directly associated with pain, and many other anatomical structures are potential etiologies. The vertebral endplates have been postulated to be a source of vertebral pain, where these endplates become particularly susceptible to increased expression of nociceptors and inflammatory proliferation carried by the basivertebral nerve (BVN), expressed on diagnostic imaging as Modic changes. This is useful diagnostic information that can help physicians to phenotype a subset of low back pain, which is known as vertebral pain, in order to directly target interventions, such as BVN ablation, to this significant pain generator. Therefore, this review describes the safety, efficacy, and the rationale behind the use of BVN ablation, a minimally invasive spinal intervention, for the treatment of vertebral pain. Our current literature review of available up-to-date publications utilizing BVN ablation in the treatment of vertebral pain suggests that there is limited, but moderate-quality evidence that this is an effective intervention for reduction of disability and improvement in function, at short- and long-term follow-up, in addition to limited moderate-quality evidence that BVN RFA is superior to conservative care for pain reduction, at least at 3-month follow-up. Our review concluded that there is a highly clinical and statistically significant treatment effect of BVN ablation for vertebral pain with clinically meaningful benefits in pain reduction, functional improvements, opioid dose reduction, and improved quality of life. There were no reported device-related patient deaths or serious AEs based on the available literature. BVN ablation is a safe, well-tolerated and clinically beneficial intervention for vertebral pain, when proper patient selection and surgical/procedural techniques are applied.Keywords: basivertebral nerve, ablation, neurotomy, vertebrogenic, vertebral pain, Modic changes