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7. A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein

Author

Yahiya, Sabrina, primary, Saunders, Charlie N., additional, Hassan, Sarah, additional, Straschil, Ursula, additional, Fischer, Oliver J., additional, Rueda-Zubiaurre, Ainoa, additional, Haase, Silvia, additional, Vizcay-Barrena, Gema, additional, Famodimu, Mufuliat Toyin, additional, Jordan, Sarah, additional, Delves, Michael J., additional, Tate, Edward W., additional, Barnard, Anna, additional, Fuchter, Matthew J., additional, and Baum, Jake, additional

Published
2023
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8. A high throughput screen for next-generation leads targeting malaria parasite transmission

Author

Delves, Michael J., Miguel-Blanco, Celia, Matthews, Holly, Molina, Irene, Ruecker, Andrea, Yahiya, Sabrina, Straschil, Ursula, Abraham, Matthew, León, María Luisa, Fischer, Oliver J., Rueda-Zubiaurre, Ainoa, Brandt, Jochen R., Cortés, Álvaro, Barnard, Anna, Fuchter, Matthew J., Calderón, Félix, Winzeler, Elizabeth A., Sinden, Robert E., Herreros, Esperanza, Gamo, Francisco J., and Baum, Jake

Published
2018
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10. Author Reply to Peer Reviews of Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development

Author

Yahiya, Sabrina, primary, Saunders, Charlie N, additional, Hassan, Sarah, additional, Straschil, Ursula, additional, Fischer, Oliver, additional, Rueda-Zubiaurre, Ainoa, additional, Haase, Silvia, additional, Vizcay-Barrena, Gema, additional, Famodimu, Mufuliat T, additional, Jordan, Sarah, additional, Delves, Michael, additional, Tate, Edward, additional, Barnard, Anna, additional, Fuchter, Matthew J, additional, and Baum, Jake, additional

Published
2022
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13. Age and frailty are independently associated with increased covid-19 mortality and increased care needs in survivors: results of an international multi-centre study

Author

Alsahab, Mustafa, Beishon, Lucy, Brown, Bryony, Burn, Elinor, Burton, Jenni K, Cox, Natalie, Dani, Melanie, Elhadi, Muhammed, Freshwater, Sarah, Gaunt, Victoria, Gordon, Adam, Goujon, Marie, Hale, Matthew, Hughes, Terry, Jackson, Thomas A, Jelley, Benjamin, Khan, Asma, Khiroya, Heena, Lal, Rajni, Madden, Katy, Magill, Laura, Masoli, Jane, Masud, Tahir, McCluskey, Lauren, McNeela, Natalie, Mohammedseid-Nurhussien, Awolkhier, Moorey, Hannah, Lochlainn, Mary Ni, Nirantharakumar, Krishnarajah, Okoth, Kelvin, Osuafor, Christopher N, Patterson, Katherine, Pearson, Grace M E, Perry, Rita, Pettitt, Michala, Pigott, Jennifer, Pinkney, Thomas, Quinn, Terence, Reynolds, Abigail, Richardson, Sarah, Sanyal, Nik, Seed, Adam, Sleeman, Isobel, Soo, Chee, Steves, Claire, Strain, W David, Taylor, Joanne, Torsney, Kelli, Welch, Carly, Wilson, Daisy, Witham, Miles, Elazeem, Hossam Aldein S Abd, Abdelhafez, Mohammed H, Abdelmalak, Amir, Abdelwahab, Omar A, Abdulhadi, Osama M A S, Adewole, Olubayode, Ahmad, Mohammed, Ahmed, Eltayeb A, Ahmed, Hazem, Ahmed, Islam A, Akcay, Mertcan, Akdeniz, Yeşim, Akın, Emrah, Akladious, Carolyn, Alessandri, Francesco, Ali, Ali, Aljafari, Abdulmalek, Aljafari, Abdulmoiz, Al-Sadawi, Mohammed, Al-Sodani, Lobna, Altintoprak, Fatih, Amaratungaz, Gitanjali, Amer, Jocelyn, Amini, Sylvia, Amir, Taha, Anandarajah, Cheran, Anders, Rachael, Ansari, Muhammed H, Appiah, Kingsley, Atia, Jolene, Atkin, Catherine, Aujayeb, Avinash, Awad, Elsayed M, Azab, Mohammed A, Azam, Mohammad T, Aziz, Sally, Azzam, Ahmed Y, Babar, Laxmi, Babb, Laura, Badh, Manpreet, Baguneid, Clare, Bailey, Emily, Baili, Efstratia, Baldwin, Sarah, Baloyiannis, Ioannis, Bannerjee, Moulinath, Barnard, Anna, Barra, Fabio, Bashir, Hannah, Bawor, Monica, Bayhan, Zülfü, Belcher, James, Belgamwar, Ravindra, Bentley, Corrina, Birchenough, Amy, Bo, Yen Nee J, Boden, Hayley R, Bouhuwaish, Ahmad, Brachini, Gioia, Bremner, Laura, Bridgwater, Hannah, Bryant, Catherine, Budd, Gabrielle, Budd, Sharon, Budzikoski, Adam, Bulla, Reem, Buondonno, Antonio, Burden, Nicole, Butt, Hejab, Capoglu, Recayi, Caracostea, Andra, Cardoso, Rifa, Carr, Alexis, Carrasco-Prats, Milagros, Cattel, Caterina, Ceccarelli, Giancarlo, Cecere, Giuseppe, Charalabopoulos, Alexandros, Charsley, Evelyn, Cheney-Lowe, Hannah, Chevallier, Theodore, Choudhry, Asad J, Ciccarone, Flavia, Cicerchia, Pierfranco M, Cirillo, Bruno, Collins, Fatma D, Comerford, Victoria, Cordie, Ahmed, Coulter, Siobhan, Coulthard, Nick, Cox, Catrin, Cox, Victoria, Crowe, Andrew, Cullen, Jack, Cummings, Jean, Cunningham, Niamh, Curley, Daniel, Currie, Hannah, Daly, Madeleine, Darley, Jay, Dattani, Nikhita, Davakis, Spyridon, Davies, Rowan, De Paola, Gilda, De Toma, Giorgio, Del Valle-Ruiz, Sergio, Deldar, Benyamin, Demir, Hakan, Desai, Arjun, Desai, Nirali, Devaney, Alice, Dew, Lindsey, Dhesi, Jugdeep, Dias, Maria, Dick, Gordon, Doddamani, Parveen, Dogra, Gurinder, Doll, Tina, Dooley, Hannah C, Dost, Samiullah, Dotchin, Catherine, Dowell, Hannah, Draghita, Ioan M, Dundas, James M, Duranti, Giulia, Dusara, Hiren, Dwivedi, Rajesh, Dyer, Adam H, Eastaugh, Alison, Edwards, Elinor, Elghazaly, Shrouk M, Elmehrath, Ahmed O, Elrick, Hope, El-Shazly, Mostafa, Emery, Alexander, Etchill, Eric W, Evans, Sarah, Evison, Felicity, Fairhead, Cassandra, Faulkner, Margherita, Felska, Agnieszka, Fernandez, Antia, Fernández-Fernández, Pedro V, Ferraiolo, Antonella, Ferrero, Simone, Fiori, Enrico, Firat, Necattin, Fisk, Gracie, Fleck, Anna, Fonsi, Giovanni B, Gabre-Kidan, Alodia, Gallo, Gaetano, Gandhi, Ratnam, Garner, Madeleine, Georgiou, Nikolaos, Gerretsen, Hannah, Ghannam, Nourhan A A, Ghobrial, Andrew, Ghobrial, Hedra, Ghufoor, Zaynub, Gibbon, Jake, Gilbert, Georgia F, Giles, Marie, Giménez-Francés, Clara, Gonullu, Emre, Gray, Amy, Gray, Joshua H, Green, Deirdre, Greene, Charlotte, Griffin, Ellanna, Griffith, Karla, Grubb, Anthony, Guan, Yue, Guerero, Daniel N, Gupta, Ayushi, Gustavino, Claudio, Guzman, Laurenny, Hadreiez, Ahmed K M, Hajiioannou, Jiannis, Hanji, Deevia, Madhavan, Deepthy Hari, Harmantepe, Tarık, Harrison, Patrick, Hart, Barbara, Haslam, Aidan, Haunton, Victoria, Haut, Elliott R, Heinsohn, Torben, Hennah, Lindsay, Hetta, Helal F, Hickman, Alexander, Hobill, Abigail, Hogan, Patrick C P, Hogan, Vesna, Holmes, Elizabeth, Honney, Katie, Hood, Katharine, Hopkinson, Katherine, Howells, Lara, Hrouda, Nicole, Hunsley, Danielle, Hurst, William, Hussein, Rand A, Ibrahim, Mohamed Eltaher A A, Ibtida, Ishmam, Ibukunoluwakitan, Aina, Ishlek, Irem, Iyer, Rishi, Jackson, Karl, Jackson, Rosie, James, Ellen, Jarvis, Hayley, Jeffs, Sophie, Jenko, Nathan, Jeyakumar, Sasha, Kabir, Shahriar, Kainth, Harjinder, Kalloo, Jason, Kanzaria, Akhil, Karapanou, Amalia, Kardaman, Nuha, Karthikeyan, Sandeep, Karunatilleke, Anne, Kelly, Mairead, Kelly, Nicola I, Khalid, Hesham, Khan, Haris, Khan, Muhammad S, King, Matthew, Kneen, Thomas, Kok, Li, Kratochwila, Chiara, Kuzeva, Aneliya, Lapolla, Pierfrancesco, Lau, Rebecca, Law, Kar Yee, Leadbetter, Aimee, Lee, Gabriel, Lee, Helena, Levinson, Gavriella, Lewis, Grace, Liakakos, Theodore, Lim, Stephen, Lis, Danielle, Livesey, Emma, López-Morales, Pedro, Lowes, Lily, Lunt, Eleanor, Lyon, Emily, Madan, Suvira, Majid, Zeinab, Malapati, Harsha, Man, Jade, Mandane, Baguiasri, Manning, Sarah H, Mantoglu, Baris, Martínez-Sanz, Nuria, Marx, William, Masood, Almontacer E B, Maughan, Tom, Mawhinney, Jamie, Maxfield, Dominic, Mayer, Jordan, Maynard, Henry, McDonald, Claire, McGovern, Aine, Mclachlan, Sophie, Medina-Manuel, Esther, Meneghini, Simona, Metcalf, Michelle, Millwood-Hargrave, John, Mingoli, Andrea, Miu, Kelvin, Mohamed, Fawsiya, Mohamed, Soha M, Hussein, Aliae A R Mohamed, Mohammad, Abdulkader, Mohammed, Aaliya, Momen, Ahmed A, Moomo, Farhana, Mora-Guzmán, Ismael, Moriarty, Lizzie, Morrin, Hamilton, Morris, Claire, Moss, Nicholas, Moustafa, Mohamed M, Mpoura, Maria, Mubin, Mohammed, Muhtaroglu, Ali, Muir, Georgina, Mulhern, Stephanie, Muller, Daniel, Murphy, Declan C, Muzammil, Bushra, Nadkarni, Varun, Nageh, Mariam Albatoul, NasrEldin, Yasmin K, Nawaz, Wasim, Nguyen, Hanna, Cheallaigh, Cliona Ni, Noar, Alexander, North, Samuel, Nwolu, Favour, O’Docherty, Alice, Odutola, Omoteniola, O’Dwyer, Sinead, Ogochukwu, Olebu, O’Mahony, Catherine, Orlando, Lia, Osterdahl, Marc, Page, Christina, Panayotidis, Ismini, Pancholi, Shivam, Parkin, Jessica, Passby, Lauren C, Pastor-Pérez, Patricia, Patel, Harnish, Patel, Shefali, Penfold, Rose, Perinpanathan, Rupini, Perivoliotis, Konstantinos, Perra, Teresa, Pinkney, Martha, Pinotti, Enrico, Porcu, Alberto, Price, Angeline, Pugliese, Francesco, Puri, Prabhleen, Pytraczyk, Sylvia, Qaiser, Yusra, Qurashi, Maria, Radenkovic, Dina, Rajeswaran, Thurkka, Rapaport, Sarah F, Razzak, Tahmina, Reilly, Lara, Reynolds, Paul, Richardson, Alexandra, Roberts, Amelia, Roberts-Rhodes, Charlotte, Robinson, Tanya, Rocca, Aldo, Ross-Skinner, Emily, Ruiz-Marín, Miguel, Ryall, Rebecca, Saad, Alshaimaa M, Saad, Mahmoud M, Sadiq, Ambreen, Sammarco, Giuseppe, Sampanis, Michail A, Sanghvi, Hazel, Sapienza, Paolo, Sayers, Ross, Scott, Luca, Sen, Michael, Shaban, Mosab A A, Shakespeare, Kathleen T, Shaw, Ellie, Shaw, Hannah, Sheldrake, Jonathan, Sim, Sing Yang, Simonelli, Luigi, Sipsas, Nikolaos V, Sivam, Jarita, Sivarajan, Sri, Smith, Jennifer, Speranza, Fabio, Spice, Claire, Stafford, Amanda, Stambollouian, Katharine, Stevens, Kent A, Stewart, Jack, Stratton, Emma, Street, Hannah, Surtees, Michael, Swinnerton, Emma, Taher, Ahmed S A, Tait, Caroline, Taylor, Amybel, Thake, Miriam, Thin, Katie, Thould, Hannah, Thyn, Thyn, To, Benjaman, Tobiss, Hannah, Toppley, Kathryn, Townsend, Liam, Tullo, Ellen, Tzovaras, George, Umeadi, Anthony, Vaidya, Hrisheekesh, Valero-Soriano, María, Varden, Rosanna, Vergani, Vittoria, Vervoort, Dominique, Vescio, Giuseppina, Vettasseri, Mark, Virk, Madiha, Vyas, Vaishali, Wagland, Joanne, Wallis, Stephanie, Warner, Chloe, Watkins, Eleanor, Watson, Hannah, Webb, Rachael, Welsh, Sarah H, West, Ruth, Whelan, Elisha, Whitney, Julie, Whitsey, Mark, Wilcock, Catherine, Wilkinson, Iain, Williams, David, Williamson, Megan, Willott, Ruth H, Wimalasundera, Mettha, Win, Yu Lelt, Winter, Laura, Worrall, Stephanie, Wright, Rebecca, Yeo, Natalie, Yeung, Eirene, Yigit, Merve, Yildiz, Yasin A, Yusuf, Humza, Zambon, Martina, Zaw, Hein, and Elabedeen, Omar Zein

Subjects
Male, Aging, medicine.medical_specialty, Frail Elderly, COVID-19, delirium, frailty, mortality, transitions of care, Cohort Studies, AcademicSubjects/MED00280, Interquartile range, Internal medicine, medicine, Dementia, Humans, Survivors, Aged, Proportional hazards model, business.industry, SARS-CoV-2, Hazard ratio, Odds ratio, General Medicine, medicine.disease, Confidence interval, frailty,COVID-19, Ageing, Delirium, Female, medicine.symptom, Geriatrics and Gerontology, business, Cohort study, Research Paper
Abstract

Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusion Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.

Published
2021

14. Plasmodium falciparumprotein Pfs16 is a target for transmission-blocking antimalarial drug development

Author

Yahiya, Sabrina, primary, Saunders, Charlie N., additional, Straschil, Ursula, additional, Fischer, Oliver J., additional, Rueda-Zubiaurre, Ainoa, additional, Haase, Silvia, additional, Vizcay-Barrena, Gema, additional, Jordan, Sarah, additional, Hassan, Sarah, additional, Delves, Michael J., additional, Tate, Edward W., additional, Barnard, Anna, additional, Fuchter, Matthew J., additional, and Baum, Jake, additional

Published
2021
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18. JHS911326 Supplemental Material2 - Supplemental material for A randomized controlled trial of real versus sham acupuncture for basal thumb joint arthritis

Author

Barnard, Anna, Jansen, Victoria, Swindells, Mark G., Arundell, Melanie, and Burke, Frank D.

Subjects
FOS: Clinical medicine, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, 110314 Orthopaedics
Abstract

Supplemental material, JHS911326 Supplemental Material2 for A randomized controlled trial of real versus sham acupuncture for basal thumb joint arthritis by Anna Barnard, Victoria Jansen, Mark G. Swindells, Melanie Arundell and Frank D. Burke in Journal of Hand Surgery (European Volume)

Published
2020
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20. Structure–Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes

Author

Rueda-Zubiaurre, Ainoa, primary, Yahiya, Sabrina, additional, Fischer, Oliver J., additional, Hu, Xiaojun, additional, Saunders, Charlie N., additional, Sharma, Sachi, additional, Straschil, Ursula, additional, Shen, Junting, additional, Tate, Edward W., additional, Delves, Michael J., additional, Baum, Jake, additional, Barnard, Anna, additional, and Fuchter, Matthew J., additional

Published
2019
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22. Essentials of Plastic Surgery

Author

Barnard, Anna R., Janis, Jeffrey E., Jones, Alex P., Barnard, Anna R., Janis, Jeffrey E., and Jones, Alex P.

Subjects
Reconstructive Surgical Procedures--Problems and
Abstract

Essentials of Plastic Surgery: Q&A Companion is the companion to Essentials of Plastic Surgery, Second Edition, which covers a wide variety of topics in aesthetic and reconstructive plastic surgery. As such, it is designed to test your knowledge of the source book, which may be helpful in the clinical setting and beyond. It presents both multiple choice questions and extended matching questions in single best answer format. The 1200 questions are carefully constructed to be practical and thorough, and are accompanied by detailed answers that help enhance understanding of both the right and wrong answers. Compact enough to fit in a lab coat pocket, its design and organization allow for quick and easy reading. The print book is accompanied by a complimentary eBook that can be accessed on smartphones and tablets. It is the go-to resource for all students of plastic surgery, whether residents in training or experienced practitioners.

Published
2016

23. Structure–Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes

Author

Rueda-Zubiaurre, Ainoa, Yahiya, Sabrina, Fischer, Oliver J., Hu, Xiaojun, Saunders, Charlie N., Sharma, Sachi, Straschil, Ursula, Shen, Junting, Tate, Edward W., Delves, Michael J., Baum, Jake, Barnard, Anna, and Fuchter, Matthew J.

Abstract

Malaria is still a leading cause of mortality among children in the developing world, and despite the immense progress made in reducing the global burden, further efforts are needed if eradication is to be achieved. In this context, targeting transmission is widely recognized as a necessary intervention toward that goal. After carrying out a screen to discover new transmission-blocking agents, herein we report our medicinal chemistry efforts to study the potential of the most robust hit, DDD01035881, as a male-gamete targeted compound. We reveal key structural features for the activity of this series and identify analogues with greater potency and improved metabolic stability. We believe this study lays the groundwork for further development of this series as a transmission blocking agent.

Published
2020
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24. Thirsty work: Exploring children's experiences of preoperative fasting.

Author

Al‐Robeye, Arwa Mohammed, Barnard, Anna Nicole, Bew, Stephanie, and Thomas, Mark

Subjects
*PREPROCEDURAL fasting, *SURGICAL complications, *THIRST, *LIKERT scale, *BREAST milk, *GENERAL anesthesia, *PEDIATRIC surgeons
Abstract

Background: Preoperative fasting is performed to reduce aspiration risk during general anesthesia. Recommendations are that patients should fast for 6 hours from solids and nonhuman milk, 4 hours from breast milk, and 2 hours from clear fluids. However, previous studies have shown that children fast far in excess of these times, which can result in perioperative complications and unnecessary discomfort for the child. Aims: This prospective, mixed‐methods study aims to explore the experiences of pediatric patients undergoing preoperative fasting in Leeds General Infirmary. It also aims to investigate fasting durations of these patients and factors which influence these. Methods: Over 2 weeks, surveys were distributed to all parents of elective pediatric patients and completed prior to their child being called to theater. Children over the age of six were offered a child survey, which had been specifically developed for the study, with visual Likert scales and an area for free text. The gathering of children's comments about their experience of preoperative fasting is unique to this study. Results: Seventy‐one parent surveys and 48 child surveys were completed, with a mean patient age of 8.3 years (SD 4.1). The mean preoperative fasting time for food was 11.7 hours (SD 4.4) and 6.9 hours (SD 5.0) for fluids. Fasting times were far in excess of the minimums recommended, negatively impacting patient experience with 34% reporting being hungry/very hungry and 19% thirsty/very thirsty. Most children's comments suggested that they coped well with the fasting; however, several children reported feelings of sadness and anxiety. Conclusion: Preoperative fasting times in pediatric patients far exceed the durations set by international guidelines. Given that many children reported extreme feelings of hunger and thirst or emotional effects from the fast, these durations need to be optimized in order to improve patient experience. [ABSTRACT FROM AUTHOR]

Published
2020
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30. Polyglycerol-based amphiphilic dendrons as potential siRNA carriers for in vivo applications

Author

Tschiche, Ariane, primary, Staedtler, Anna M., additional, Malhotra, Shashwat, additional, Bauer, Hannah, additional, Böttcher, Christoph, additional, Sharbati, Soroush, additional, Calderón, Marcelo, additional, Koch, Markus, additional, Zollner, Thomas M., additional, Barnard, Anna, additional, Smith, David K., additional, Einspanier, Ralf, additional, Schmidt, Nicole, additional, and Haag, Rainer, additional

Published
2014
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31. Orthogonal functionalisation of α-helix mimetics

Author

Barnard, Anna, primary, Long, Kérya, additional, Yeo, David J., additional, Miles, Jennifer A., additional, Azzarito, Valeria, additional, Burslem, George M., additional, Prabhakaran, Panchami, additional, A. Edwards, Thomas, additional, and Wilson, Andrew J., additional

Published
2014
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41. Macromol. Biosci. 12/2011

Author

Fischer, Wiebke, primary, Quadir, Mohiuddin A., additional, Barnard, Anna, additional, Smith, David K., additional, and Haag, Rainer, additional

Published
2011
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47. Design, synthesis and conformational analysis of multi-facial helix mimetics

Author

Flack, Theo, Barnard, Anna, and Tate, Edward

Abstract

The inhibition of protein-protein interactions using rationally designed molecules is a powerful method for exploring the biological role of these interactions, particularly in the pathogenesis of many common diseases. The most common molecular recognition scaffold in multi-protein complexes is the a-helix and as such numerous helix mimetic designs have been reported.1 However, the majority of these designs have focused of mimicry of a single helical face. Given that many therapeutically relevant interactions are mediated through the binding of multiple helical faces, multi-facial helix mimetics represent a promising method for PPI inhibition.2 This thesis will describe the synthesis and characterisation of an oligoamide scaffold capable of projecting functionality that represents two distinct helical faces. A modular solution-phase synthetic route capabale of incorporating functionality found across all proteinogenic amino acids has been designed. The conformational landscape of the helix mimetics have been extensively studied using both solution- and solid-phase techniques. A series of bifunctional helix mimetics have been designed based on the helical tail of MyosinA (MyoA); a key component of the invasion machinery of Plasmodium parasites. The ability of the mimetics to perturb the motor complex has been established using a cascade of biophysical techniques. In addition, a series of peptide-helix mimetic chimeras have been synthesised by replacing sequential helical turns with topographical mimics. It was established that coupling the native recognition properties of peptides with the enhanced structural and metabolic stability of helix mimetics could potentially permit the assembly of protein-like objects with superior functionality compared to the native peptide and helix mimetics alone. It is anticipated that the approaches presented here will afford translatable designs for peptidomimetics capable of inhibiting a variety of complex PPIs.

Published
2019
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48. A randomized controlled trial of real versus sham acupuncture for basal thumb joint arthritis.

Author

Barnard A, Jansen V, Swindells MG, Arundell M, and Burke FD

Subjects
Humans, Pain Management, Thumb, Treatment Outcome, Acupuncture Therapy, Arthritis therapy, Hand Joints
Abstract

We report a single-blinded randomized controlled trial comparing acupuncture to sham (non-penetrating) needling for relief of symptoms of basal thumb joint arthritis. Seventy acupuncture naive patients with basal thumb joint arthritis were randomized to receive true acupuncture or sham needling with 35 patients in each arm. Blinded baseline and post-treatment assessments included visual analogue pain scores for different grips and movement. Function was assessed using the Nelson questionnaire. Both groups showed statistically and clinically significant improvements in pain at week one post-treatment compared with baseline, but there was no difference between the treatment groups. The pain relief was comparable with published data for some standard treatments. Acupuncture did not perform better than sham needling in this study, indicating that pain relief may have been achieved through non-specific mechanisms. Level of evidence: I.

Published
2020
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49. Selective and potent proteomimetic inhibitors of intracellular protein-protein interactions.

Author

Barnard A, Long K, Martin HL, Miles JA, Edwards TA, Tomlinson DC, Macdonald A, and Wilson AJ

Subjects
Cell Line, Tumor, Humans, Molecular Mimicry, Proteins chemistry
Abstract

Inhibition of protein-protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α-Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed "proteomimetics", which can be assembled in a modular manner to reproduce the vectoral presentation of key side chains found on a helical motif from one partner within the PPI. In this work, it is demonstrated that by using a library of N-alkylated aromatic oligoamide helix mimetics, potent helix mimetics which reproduce their biophysical binding selectivity in a cellular context can be identified., (© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.)

Published
2015
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50. Orthogonal functionalisation of α-helix mimetics.

Author

Barnard A, Long K, Yeo DJ, Miles JA, Azzarito V, Burslem GM, Prabhakaran P, A Edwards T, and Wilson AJ

Subjects
Amides chemistry, Biomimetics, Click Chemistry, Humans, Inhibitory Concentration 50, Myeloid Cell Leukemia Sequence 1 Protein chemistry, Protein Binding, Protein Interaction Mapping, Protein Structure, Secondary, Proteomics methods, Proto-Oncogene Proteins c-mdm2 antagonists & inhibitors, Solvents chemistry, Surface Properties, Tumor Suppressor Protein p53 antagonists & inhibitors, bcl-X Protein chemistry, Proto-Oncogene Proteins c-mdm2 chemistry, Tumor Suppressor Protein p53 chemistry
Abstract

α-Helix mediated protein-protein interactions are of major therapeutic importance. As such, the design of inhibitors of this class of interaction is of significant interest. We present methodology to modify N-alkylated aromatic oligoamide α-helix mimetics using 'click' chemistry. The effect is shown to modulate the binding properties of a series of selective p53/hDM2 inhibitors.

Published
2014
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