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16 results on '"Barna, Agnes"'

1. The Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML): A representative and useful real-life data source for further biomedical research

Author

Geissler, Klaus, Jäger, Eva, Barna, Agnes, Gurbisz, Michael, Marschon, Renate, Graf, Temeida, Graf, Elmir, Borjan, Bojana, Jilch, Ruth, Geissler, Christoph, Hoermann, Gregor, Esterbauer, Harald, Schwarzinger, Ilse, Nösslinger, Thomas, Pfeilstöcker, Michael, Tüchler, Heinz, Reisner, Regina, Sliwa, Thamer, Keil, Felix, Bettelheim, Peter, Machherndl-Spandl, Sigrid, Doleschal, Bernhard, Zach, Otto, Weltermann, Ansgar, Heibl, Sonja, Thaler, Josef, Zebisch, Armin, Sill, Heinz, Stauder, Reinhard, Webersinke, Gerald, Petzer, Andreas, Kusec, Rajko, Ulsperger, Ernst, Schneeweiss, Bruno, Berger, Jörg, Öhler, Leopold, Germing, Ulrich, Sperr, Wolfgang R., Knöbl, Paul, Jäger, Ulrich, and Valent, Peter

Published
2019
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2. Multistep pathogenesis of chronic myelomonocytic leukemia in patients

Author

Geissler, Klaus, primary, Jäger, Eva, additional, Barna, Agnes, additional, Gurbisz, Michael, additional, Marschon, Renate, additional, Graf, Temeida, additional, Nösslinger, Thomas, additional, Pfeilstöcker, Michael, additional, Machherndl‐Spandl, Sigrid, additional, Stauder, Reinhard, additional, Zebisch, Armin, additional, Sill, Heinz, additional, Öhler, Leopold, additional, Kusec, Rajko, additional, Hoermann, Gregor, additional, and Valent, Peter, additional

Published
2022
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3. Impact of age on the cumulative risk of transformation in patients with chronic myelomonocytic leukaemia

Author

Machherndl‐Spandl, Sigrid, primary, Jäger, Eva, additional, Barna, Agnes, additional, Gurbisz, Michael, additional, Marschon, Renate, additional, Graf, Temeida, additional, Graf, Elmir, additional, Geissler, Christoph, additional, Hoermann, Gregor, additional, Nösslinger, Thomas, additional, Pfeilstöcker, Michael, additional, Bettelheim, Peter, additional, Zach, Otto, additional, Weltermann, Ansgar, additional, Heibl, Sonja, additional, Thaler, Josef, additional, Zebisch, Armin, additional, Sill, Heinz, additional, Stauder, Reinhard, additional, Webersinke, Gerald, additional, Kusec, Rajko, additional, Ulsperger, Ernst, additional, Schneeweiss, Bruno, additional, Öhler, Leopold, additional, Germing, Ulrich, additional, Valent, Peter, additional, Tüchler, Heinz, additional, and Geissler, Klaus, additional

Published
2021
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5. Impact of RAS-Pathway Activation on Phenotype and Outcome in Patients with Chronic Myelomonocytic Leukemia and a TET2/SRSF2 Comutation

Author

Geissler, Klaus, primary, Jäger, Eva, additional, Barna, Agnes, additional, Gurbisz, Michael, additional, Graf, Temeida, additional, Graf, Elmir, additional, Stegemann, Maike, additional, Nösslinger, Thomas, additional, Pfeilstöcker, Michael, additional, Machherndl-Spandl, Sigrid, additional, and Staude, Reinhard, additional

Published
2021
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6. Molecular Basis and Clinical Application of Growth-Factor-Independent In Vitro Myeloid Colony Formation in Chronic Myelomonocytic Leukemia

Author

Geissler, Klaus, primary, Jäger, Eva, additional, Barna, Agnes, additional, Gurbisz, Michael, additional, Graf, Temeida, additional, Graf, Elmir, additional, Nösslinger, Thomas, additional, Pfeilstöcker, Michael, additional, Machherndl-Spandl, Sigrid, additional, Stauder, Reinhard, additional, Zebisch, Armin, additional, Sill, Heinz, additional, Öhler, Leopold, additional, Kusec, Rajko, additional, Hörmann, Gregor, additional, and Valent, Peter, additional

Published
2020
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7. Clinical, Hematologic, Biologic and Molecular Characteristics of Patients with Myeloproliferative Neoplasms and a Chronic Myelomonocytic Leukemia-Like Phenotype

Author

Heibl, Sonja, primary, Gisslinger, Bettina, additional, Jäger, Eva, additional, Barna, Agnes, additional, Gurbisz, Michael, additional, Stegemann, Maike, additional, Bettelheim, Peter, additional, Machherndl-Spandl, Sigrid, additional, Pfeilstöcker, Michael, additional, Nösslinger, Thomas, additional, Uyanik, Gökhan, additional, Hoermann, Gregor, additional, Stauder, Reinhard, additional, Thaler, Josef, additional, Kusec, Rajko, additional, Valent, Peter, additional, Gisslinger, Heinz, additional, and Geissler, Klaus, additional

Published
2020
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8. Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia—A Retrospective Analysis in 337 Patients

Author

Geissler, Klaus, primary, Jäger, Eva, additional, Barna, Agnes, additional, Gurbisz, Michael, additional, Graf, Temeida, additional, Graf, Elmir, additional, Nösslinger, Thomas, additional, Pfeilstöcker, Michael, additional, Tüchler, Heinz, additional, Sliwa, Thamer, additional, Keil, Felix, additional, Geissler, Christoph, additional, Heibl, Sonja, additional, Thaler, Josef, additional, Machherndl-Spandl, Sigrid, additional, Zach, Otto, additional, Weltermann, Ansgar, additional, Bettelheim, Peter, additional, Stauder, Reinhard, additional, Zebisch, Armin, additional, Sill, Heinz, additional, Schwarzinger, Ilse, additional, Schneeweiss, Bruno, additional, Öhler, Leopold, additional, Ulsperger, Ernst, additional, Kusec, Rajko, additional, Germing, Ulrich, additional, Sperr, Wolfgang R., additional, Knöbl, Paul, additional, Jäger, Ulrich, additional, Hörmann, Gregor, additional, and Valent, Peter, additional

Published
2020
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9. High Spontaneous In Vitro Myeloid Colony Formation in Chronic Myelomonocytic Leukemia is Associated with Mutations in Rasopathy Genes, Myeloproliferation and Inferior Prognosis

Author

Geissler, Klaus, primary, Barna, Agnes, additional, Jäger, Eva, additional, Alendar, Temeida, additional, Ljubuncic, Elmir, additional, Jilch, Ruth, additional, Nösslinger, Thomas, additional, Pfeilstöcker, Michael, additional, Tüchler, Heinz, additional, Reisner, Regina, additional, Sliwa, Thamer, additional, Keil, Felix, additional, Burgstaller, Sonja, additional, Thaler, Josef, additional, Machherndl-Spandl, Sigrid, additional, Zach, Otto, additional, Weltermann, Ansgar, additional, Bettelheim, Peter, additional, Stauder, Reinhard, additional, Schwarzinger, Ilse, additional, Hörmann, Gregor, additional, Jäger, Ulrich, additional, Sperr, Wolfgang R., additional, Knöbl, Paul, additional, Schneeweiss, Bruno, additional, Berger, Jörg, additional, Kusec, Rajko, additional, Öhler, Leopold, additional, Zebisch, Armin, additional, Sill, Heinz, additional, Germing, Ulrich, additional, and Valent, Peter, additional

Published
2016
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10. Clinical, Hematological, and Biologic Characteristics in Chronic Myelomonocytic Leukemia Patients with a JAK2 V617F Mutation

Author

Geissler, Klaus, primary, Barna, Agnes, additional, Jäger, Eva, additional, Alendar, Temeida, additional, Ljubuncic, Elmir, additional, Jilch, Ruth, additional, Nösslinger, Thomas, additional, Pfeilstöcker, Michael, additional, Tüchler, Heinz, additional, Reisner, Regina, additional, Sliwa, Thamer, additional, Keil, Felix, additional, Burgstaller, Sonja, additional, Thaler, Josef, additional, Machherndl-Spandl, Sigrid, additional, Zach, Otto, additional, Weltermann, Ansgar, additional, Bettelheim, Peter, additional, Stauder, Reinhard, additional, Schwarzinger, Ilse, additional, Hörmann, Gregor, additional, Jäger, Ulrich, additional, Sperr, Wolfgang R., additional, Knöbl, Paul, additional, Schneeweiss, Bruno, additional, Berger, Jörg, additional, Kusec, Rajko, additional, Öhler, Leopold, additional, Zebisch, Armin, additional, Sill, Heinz, additional, Germing, Ulrich, additional, and Valent, Peter, additional

Published
2016
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12. Quantitative Analysis of Mutant Subclones in Chronic Myeloid Leukemia: Comparison of Different Methodological Approaches

Author

Preuner, Sandra, primary, Barna, Agnes, additional, Frommlet, Florian, additional, Czurda, Stefan, additional, Konstantin, Byrgazov, additional, Alikian, Mary, additional, Machova Polakova, Katerina, additional, Sacha, Tomasz, additional, Richter, Johan, additional, Lion, Thomas, additional, and Gabriel, Christian, additional

Published
2016
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14. High Spontaneous In VitroMyeloid Colony Formation in Chronic Myelomonocytic Leukemia is Associated with Mutations in Rasopathy Genes, Myeloproliferation and Inferior Prognosis

Author

Geissler, Klaus, Barna, Agnes, Jäger, Eva, Alendar, Temeida, Ljubuncic, Elmir, Jilch, Ruth, Nösslinger, Thomas, Pfeilstöcker, Michael, Tüchler, Heinz, Reisner, Regina, Sliwa, Thamer, Keil, Felix, Burgstaller, Sonja, Thaler, Josef, Machherndl-Spandl, Sigrid, Zach, Otto, Weltermann, Ansgar, Bettelheim, Peter, Stauder, Reinhard, Schwarzinger, Ilse, Hörmann, Gregor, Jäger, Ulrich, Sperr, Wolfgang R., Knöbl, Paul, Schneeweiss, Bruno, Berger, Jörg, Kusec, Rajko, Öhler, Leopold, Zebisch, Armin, Sill, Heinz, Germing, Ulrich, and Valent, Peter

Abstract

Background:Chronic myelomonocytic leukemia (CMML) is a hematopoietic malignancy with features of both a myelodysplastic syndrome and a myeloproliferative neoplasm.The pathogenesis of CMML is incompletely understood due to the large heterogeneity of molecular aberrations in genes involved in epigenetic regulation, RNA-splicing and signal transduction including components of RAS and JAK2 signaling. Functional tests may be important to better estimate the contribution of a particular molecular aberration in the pathogenesis of the malignancy. We have originally demonstrated extensive in vitroformation of myeloid colonies (CFU-GM) without addition of exogenous growth factors in a subset of patients with CMML (Geissler et al, Leuk Res1988). We reported that this spontaneous CFU-GM colony formation in CMML is a GM-CSF dependent in vitrophenomenon (Geissler et al, J Exp Med1996) and could also show in a small retrospective study that CMML patients with high spontaneous CFU-GM growth (>100/105PBMNC) have a worse prognosis compared to patients with low myeloid colony formation (Sagaster et al, Ann Hematol2004) suggesting a clinical significance of our observation. In juvenile myelomonocytic leukemia, in which molecular aberrations are mainly restricted to the RASopathy genes including NRAS, KRAS, NF1, CBL and PTPN11, spontaneous formation of CFU-GM due to GM-CSF-specific hypersensitivity is a hallmark feature of disease, which has been included in the diagnostic criteria. We therefore speculated that high spontaneous myeloid colony formation in CMML might also reflect hyperactivation of the RAS signaling pathway.

Published
2016
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15. Clinical, Hematological, and Biologic Characteristics in Chronic Myelomonocytic Leukemia Patients with a JAK2V617F Mutation

Author

Geissler, Klaus, Barna, Agnes, Jäger, Eva, Alendar, Temeida, Ljubuncic, Elmir, Jilch, Ruth, Nösslinger, Thomas, Pfeilstöcker, Michael, Tüchler, Heinz, Reisner, Regina, Sliwa, Thamer, Keil, Felix, Burgstaller, Sonja, Thaler, Josef, Machherndl-Spandl, Sigrid, Zach, Otto, Weltermann, Ansgar, Bettelheim, Peter, Stauder, Reinhard, Schwarzinger, Ilse, Hörmann, Gregor, Jäger, Ulrich, Sperr, Wolfgang R., Knöbl, Paul, Schneeweiss, Bruno, Berger, Jörg, Kusec, Rajko, Öhler, Leopold, Zebisch, Armin, Sill, Heinz, Germing, Ulrich, and Valent, Peter

Published
2016
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