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2. Identification of disease phenotypes in acetylcholine receptor-antibody myasthenia gravis using proteomics-based consensus clustering

Author

Nelke, Christopher, Schroeter, Christina B., Barman, Sumanta, Stascheit, Frauke, Masanneck, Lars, Theissen, Lukas, Huntemann, Niklas, Walli, Sara, Cengiz, Derya, Dobelmann, Vera, Vogelsang, Anna, Pawlitzki, Marc, Räuber, Saskia, Konen, Felix F., Skripuletz, Thomas, Hartung, Hans-Peter, König, Simone, Roos, Andreas, Meisel, Andreas, Meuth, Sven G., and Ruck, Tobias

Published
2024
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3. Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis

Author

Wright, Sukhvir K., Rosch, Richard E., Wilson, Max A., Upadhya, Manoj A., Dhangar, Divya R., Clarke-Bland, Charlie, Wahid, Tamara T., Barman, Sumanta, Goebels, Norbert, Kreye, Jakob, Prüss, Harald, Jacobson, Leslie, Bassett, Danielle S., Vincent, Angela, Greenhill, Stuart D., and Woodhall, Gavin L.

Published
2021
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4. Classifying flow cytometry data using Bayesian analysis helps to distinguish ALS patients from healthy controls

Author

Räuber, Saskia, primary, Nelke, Christopher, additional, Schroeter, Christina B., additional, Barman, Sumanta, additional, Pawlitzki, Marc, additional, Ingwersen, Jens, additional, Akgün, Katja, additional, Günther, Rene, additional, Garza, Alejandra P., additional, Marggraf, Michaela, additional, Dunay, Ildiko Rita, additional, Schreiber, Stefanie, additional, Vielhaber, Stefan, additional, Ziemssen, Tjalf, additional, Melzer, Nico, additional, Ruck, Tobias, additional, Meuth, Sven G., additional, and Herty, Michael, additional

Published
2023
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8. Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity

Author

Ruck, Tobias, primary, Barman, Sumanta, additional, Schulte-Mecklenbeck, Andreas, additional, Pfeuffer, Steffen, additional, Steffen, Falk, additional, Nelke, Christopher, additional, Schroeter, Christina B., additional, Willison, Alice, additional, Heming, Michael, additional, Müntefering, Thomas, additional, Melzer, Nico, additional, Krämer, Julia, additional, Lindner, Maren, additional, Riepenhausen, Marianne, additional, Gross, Catharina C., additional, Klotz, Luisa, additional, Bittner, Stefan, additional, Muraro, Paolo A., additional, Schneider-Hohendorf, Tilman, additional, Schwab, Nicholas, additional, Meyer zu Hörste, Gerd, additional, Goebels, Norbert, additional, Meuth, Sven G., additional, and Wiendl, Heinz, additional

Published
2022
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9. Myelinating Co-Culture as a Model to Study Anti-NMDAR Neurotoxicity.

Author

Sabet, Mercedeh Farhat, Barman, Sumanta, Beller, Mathias, Meuth, Sven G., Melzer, Nico, Aktas, Orhan, Goebels, Norbert, and Prozorovski, Tim

Subjects
*MYELIN proteins, *NEUROMYELITIS optica, *DEMYELINATION, *SPINAL cord, *CEREBROSPINAL fluid, *OLIGODENDROGLIA, *NEUROTOXICOLOGY
Abstract

Anti-NMDA receptor (NMDAR) encephalitis is frequently associated with demyelinating disorders (e.g., multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein-associated disease (MOGAD)) with regard to clinical presentation, neuropathological and cerebrospinal fluid findings. Indeed, autoantibodies (AABs) against the GluN1 (NR1) subunit of the NMDAR diminish glutamatergic transmission in both neurons and oligodendrocytes, leading to a state of NMDAR hypofunction. Considering the vital role of oligodendroglial NMDAR signaling in neuron-glia communication and, in particular, in tightly regulated trophic support to neurons, the influence of GluN1 targeting on the physiology of myelinated axon may be of importance. We applied a myelinating spinal cord cell culture model that contains all major CNS cell types, to evaluate the effects of a patient-derived GluN1-specific monoclonal antibody (SSM5) on neuronal and myelin integrity. A non-brain reactive (12D7) antibody was used as the corresponding isotype control. We show that in cultures at the late stage of myelination, prolonged treatment with SSM5, but not 12D7, leads to neuronal damage. This is characterized by neurite blebbing and fragmentation, and a reduction in the number of myelinated axons. However, this significant toxic effect of SSM5 was not observed in earlier cultures at the beginning of myelination. Anti-GluN1 AABs induce neurodegenerative changes and associated myelin loss in myelinated spinal cord cultures. These findings may point to the higher vulnerability of myelinated neurons towards interference in glutamatergic communication, and may refer to the disturbance of the NMDAR-mediated oligodendrocyte metabolic supply. Our work contributes to the understanding of the emerging association of NMDAR encephalitis with demyelinating disorders. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis

Author

Wright, Sukhvir K, Rosch, Richard E, Wilson, Max A, Upadhya, Manoj A, Dhangar, Divya R, Clarke-Bland, Charlie, Wahid, Tamara T, Barman, Sumanta, Goebels, Norbert, Kreye, Jakob, Prüss, Harald, Jacobson, Leslie, Bassett, Danielle S, Vincent, Angela, Greenhill, Stuart D, Woodhall, Gavin L, Wright, Sukhvir K, Rosch, Richard E, Wilson, Max A, Upadhya, Manoj A, Dhangar, Divya R, Clarke-Bland, Charlie, Wahid, Tamara T, Barman, Sumanta, Goebels, Norbert, Kreye, Jakob, Prüss, Harald, Jacobson, Leslie, Bassett, Danielle S, Vincent, Angela, Greenhill, Stuart D, and Woodhall, Gavin L

Abstract

Seizures are a prominent feature in N-Methyl-D-Aspartate receptor antibody (NMDAR antibody) encephalitis, a distinct neuro-immunological disorder in which specific human autoantibodies bind and crosslink the surface of NMDAR proteins thereby causing internalization and a state of NMDAR hypofunction. To further understand ictogenesis in this disorder, and to test a potential treatment compound, we developed an NMDAR antibody mediated rat seizure model that displays spontaneous epileptiform activity in vivo and in vitro. Using a combination of electrophysiological and dynamic causal modelling techniques we show that, contrary to expectation, reduction of synaptic excitatory, but not inhibitory, neurotransmission underlies the ictal events through alterations in the dynamical behaviour of microcircuits in brain tissue. Moreover, in vitro application of a neurosteroid, pregnenolone sulphate, that upregulates NMDARs, reduced established ictal activity. This proof-of-concept study highlights the complexity of circuit disturbances that may lead to seizures and the potential use of receptor-specific treatments in antibody-mediated seizures and epilepsy.

Published
2021

11. In vitro characterisation and neurosteroid treatment of an N-Methyl-D-Aspartate receptor antibody-mediated seizure model

Author

Wright, Sukhvir K, primary, Rosch, Richard E, additional, Wilson, Max A, additional, Upadhya, Manoj A, additional, Dhangar, Divya R, additional, Clarke-Bland, Charlie, additional, Wahid, Tamara T, additional, Barman, Sumanta, additional, Goebels, Norbert, additional, Kreye, Jakob, additional, Prüss, Harald, additional, Jacobson, Leslie, additional, Bassett, Danielle S, additional, Vincent, Angela, additional, Greenhill, Stuart D, additional, and Woodhall, Gavin L, additional

Published
2020
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13. Characterization of T cells in NMOSD patients - an emerging role for T cells in disease pathogenesis (4017)

Author

Lindner, Maren, primary, Bhatia, Urvashi, additional, Schulte-Mecklenbeck, Andreas, additional, Wirth, Timo, additional, Gross, Catharina, additional, Schmidt, Tyge, additional, Korsen, Melanie, additional, Schneider-Hohendorf, Tilman, additional, Schwab, Nicholas, additional, Barman, Sumanta, additional, Aktas, Orhan, additional, Goebels, Norbert, additional, Winkler, Anne, additional, Stadelmann-Nessler, Christine, additional, Brueck, Wolfgang, additional, Kuempfel, Tania, additional, Siebert, Nadja, additional, Paul, Friedemann, additional, Kleiter, Ingo, additional, Wiendl, Heinz, additional, Kuhlmann, Tanja, additional, Ringelstein, Marius, additional, and Klotz, Luisa, additional

Published
2020
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15. An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis

Author

Amedonu, Elsie, primary, Brenker, Christoph, additional, Barman, Sumanta, additional, Schreiber, Julian A., additional, Becker, Sebastian, additional, Peischard, Stefan, additional, Strutz-Seebohm, Nathalie, additional, Strippel, Christine, additional, Dik, Andre, additional, Hartung, Hans-Peter, additional, Budde, Thomas, additional, Wiendl, Heinz, additional, Strünker, Timo, additional, Wünsch, Bernhard, additional, Goebels, Norbert, additional, Meuth, Sven G., additional, Seebohm, Guiscard, additional, and Melzer, Nico, additional

Published
2019
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16. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody (S52.006)

Author

Malviya, Manish, primary, Barman, Sumanta, additional, Golombeck, Kristin, additional, Falk, Kim Kristin, additional, Planagumà, Jesús, additional, Mannara, Francesco, additional, Strutz-Seebohm, Nathalie, additional, Seebohm, Guiscard, additional, Leypoldt, Frank, additional, Meuth, Sven, additional, Wiendl, Heinz, additional, Hartung, Hans-Peter, additional, Dalmau, Josep, additional, Melzer, Nico, additional, and Goebels, Norbert, additional

Published
2018
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17. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody

Author

Malviya, Manish, primary, Barman, Sumanta, additional, Golombeck, Kristin S., additional, Planagumà, Jesús, additional, Mannara, Francesco, additional, Strutz-Seebohm, Nathalie, additional, Wrzos, Claudia, additional, Demir, Fatih, additional, Baksmeier, Christine, additional, Steckel, Julia, additional, Falk, Kim Kristin, additional, Gross, Catharina C., additional, Kovac, Stjepana, additional, Bönte, Kathrin, additional, Johnen, Andreas, additional, Wandinger, Klaus-Peter, additional, Martín-García, Elena, additional, Becker, Albert J., additional, Elger, Christian E., additional, Klöcker, Nikolaj, additional, Wiendl, Heinz, additional, Meuth, Sven G., additional, Hartung, Hans-Peter, additional, Seebohm, Guiscard, additional, Leypoldt, Frank, additional, Maldonado, Rafael, additional, Stadelmann, Christine, additional, Dalmau, Josep, additional, Melzer, Nico, additional, and Goebels, Norbert, additional

Published
2017
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20. Genetic diversity analysis of chewing sugarcane (Saccharum officinarum L.) varieties by using RAPD markers.

Author

Sarid Ullah, S. M., Hossain, Md. Amzad, Hossain, Md. Musharaf, Barman, Sumanta, Hasan Sohag, Md. Mehadi, and Prodhan, Shamsul H.

Subjects
CROP yields, SUGARCANE, DNA analysis, SPECTROPHOTOMETRY, SUGAR crops, SACCHARUM
Abstract

In the present study an efficient and easy method was followed for the isolation of DNA from meristem cylinder in five chewing sugarcane varieties, namely Amrita, Bomaby, Babulal (Co.527), Q83 and Misrimala. The quality and quantity of DNA were assured by visual estimation using agarose gel electrophoresis and UV spectrophotometry. The highest amount of DNA was retrieved from the Amrita (3250 ng/ml) and the lowest amount was attained from the variety Q83 (1450 ng/ml). The amount of recovered DNA was enough for PCR amplification and marker studies such as random amplified polymorphic DNA (RAPD). Using RAPD markers, bands obtained from fingerprinting (190 bp to 1200 bp) showed 73.5% polymorphism. The dendrogram, based on linkage distance using unweighted pair group method of arithmetic means (UPGMA), indicated segregation of the five chewing varieties of sugarcane into two main clusters. Amrita, Bombay and Misrimala were grouped in cluster 1 (C1) followed by subclusters. Babulal and Q83 were grouped in cluster 2 (C2). The results of the present investigation also revealed that the twenty RAPD primers were able to identify and classify the chewing sugarcane varieties based on their genetic relationship. [ABSTRACT FROM AUTHOR]

Published
2013

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