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Manganese hydroxido (Mn-OH) complexes supported by a tripodal N,N,N″-[nitrilotris(ethane-2,1-diyl)]tris(P,P-diphenylphosphinic amido) ([poat]3-) ligand have been synthesized and characterized by spectroscopic techniques including UV-vis and electron paramagnetic resonance (EPR) spectroscopies. X-ray diffraction (XRD) methods were used to confirm the solid-state molecular structures of {Na2[MnIIpoat(OH)]}2 and {Na[MnIIIpoat(OH)]}2 as clusters that are linked by the electrostatic interactions between the sodium counterions and the oxygen atom of the ligated hydroxido unit and the phosphinic (P=O) amide groups of [poat]3-. Both clusters feature two independent monoanionic fragments in which each contains a trigonal bipyramidal Mn center that is comprised of three equatorial deprotonated amide nitrogen atoms, an apical tertiary amine, and an axial hydroxido ligand. XRD analyses of {Na[MnIIIpoat(OH)]}2 also showed an intramolecular hydrogen bonding interaction between the MnIII-OH unit and P=O group of [poat]3-. Crystalline {Na[MnIIIpoat(OH)]}2 remains as clusters with Na+---O interactions in solution and is unreactive toward external substrates. However, conductivity studies indicated that [MnIIIpoat(OH)]- generated in situ is monomeric and reactivity studies found that it is capable of cleaving C-H bonds, illustrating the importance of solution-phase speciation and its direct effect on chemical reactivity. Synopsis: Manganese-hydroxido complexes were synthesized to study the influence of H-bonds in the secondary coordination sphere and their effects on the oxidative cleavage of substrates containing C-H bonds.

The functionalization of C-H bonds is one of the most challenging transformations in synthetic chemistry. In biology, these processes are well-known and are achieved with a variety of metalloenzymes, many of which contain a single metal center within their active sites. The most well studied are those with Fe centers, and the emerging experimental data show that high-valent iron oxido species are the intermediates responsible for cleaving the C-H bond. This Forum Article describes the state of this field with an emphasis on nonheme Fe enzymes and current experimental results that provide insights into the properties that make these species capable of C-H bond cleavage. These parameters are also briefly considered in regard to manganese oxido complexes and Cu-containing metalloenzymes. Synthetic iron oxido complexes are discussed to highlight their utility as spectroscopic and mechanistic probes and reagents for C-H bond functionalization. Avenues for future research are also examined.

The oxidation of substrates via the cleavage of thermodynamically strong C-H bonds is an essential part of mammalian metabolism. These reactions are predominantly carried out by enzymes that produce high-valent metal-oxido species, which are directly responsible for cleaving the C-H bonds. While much is known about the identity of these transient intermediates, the mechanistic factors that enable metal-oxido species to accomplish such difficult reactions are still incomplete. For synthetic metal-oxido species, C-H bond cleavage is often mechanistically described as synchronous, proton-coupled electron transfer (PCET). However, data have emerged that suggest that the basicity of the M-oxido unit is the key determinant in achieving enzymatic function, thus requiring alternative mechanisms whereby proton transfer (PT) has a more dominant role than electron transfer (ET). To bridge this knowledge gap, the reactivity of a monomeric MnIV-oxido complex with a series of external substrates was studied, resulting in a spread of over 104 in their second-order rate constants that tracked with the acidity of the C-H bonds. Mechanisms that included either synchronous PCET or rate-limiting PT, followed by ET, did not explain our results, which led to a proposed PCET mechanism with asynchronous transition states that are dominated by PT. To support this premise, we report a semiempirical free energy analysis that can predict the relative contributions of PT and ET for a given set of substrates. These findings underscore why the basicity of M-oxido units needs to be considered in C-H functionalization.

The functionalization of C-H bonds is an essential reaction in biology and chemistry. Metalloenzymes that often exhibit this type of reactivity contain metal-oxido intermediates that are directly involved in the initial cleavage of the C-H bonds. Regulation of the cleavage process is achieved, in part, by hydrogen bonds that are proximal to the metal-oxido units, yet our understanding of their exact role(s) is still emerging. To gain further information into the role of H-bonds on C-H bond activation, a hybrid set of urea-containing tripodal ligands has been developed in which a single H-bond can be adjusted through changes in the properties of one ureayl N-H bond. This modularity is achieved by appending a phenyl ring with different para-substituents from one ureayl NH group. The ligands have been used to prepare a series of MnIII-oxido complexes, and a Hammett correlation was found between the pKa values of the complexes and the substituents on the phenyl ring that was explained within the context of changes to the H-bonds involving the MnIII-oxido unit. The complexes were tested for their reactivity toward 9,10-dihydroanthracene (DHA), and a Hammett correlation was found between the second-order rate constants for the reactions and the pKa values. Studies to determine activation parameters and the kinetic isotope effects are consistent with a mechanism in which rate-limiting proton transfer is an important contributor. However, additional reactivity studies with xanthene found a significant increase in the rate constant compared to DHA, even though the substrates have the same pKa(C-H) values. These results do not support a discrete proton-transfer/electron-transfer process, but rather an asynchronous mechanism in which the proton and electron are transferred unequally at the transition state.

This paper presents the synthesis and characterization of a series of novel monomeric aqua‐ligated iron(III) complexes, [FeIII(L5R)(OH2)]2+ (R=OMe, H, Cl, NO2), supported by an amide‐containing pentadentate N5 donor ligand, L5R [HL5R=2‐(((1‐methyl‐1H‐imidazol‐2‐yl)methyl)(pyridin‐2‐yl‐methyl)amino)‐N‐(5‐R‐quinolin‐8‐yl)acetamide]. The complexes were characterized by various spectroscopic and analytical techniques, including electrochemistry and magnetic measurements. The Fe(III)‐hydroxo complexes, [FeIII(L5R)(OH)]1+, were generated in situ by deprotonating the corresponding aqua complexes in a pH ~7 aqueous medium. In another way, adding one equivalent of a base to a methanolic solution of the Fe(III)‐aqua complexes also produced the Fe(III)‐hydroxo complexes. The study uses linoleic fatty acid as a substrate to explore the hydrogen atom abstraction (HAA) reactivity of both hydroxo and aqua complexes. The investigation highlights the substitution effect of the L5R ligand on reactivity, revealing a higher rate when an electron‐withdrawing group is present. Hammett analyses and(or) determination of the asynchronicity factor (η) suggest an oxidative asynchronous concerted proton‐electron transfer (CPET) pathway for the HAA reactions. Aqua complexes exhibited a higher asynchronicity in CPET, resulting in higher reaction rates than their hydroxo analogs. Overall, the work provides insights into the beneficial role of a higher imbalance in electron‐transfer‐proton‐transfer (ET‐PT) contributions in HAA reactivity. [ABSTRACT FROM AUTHOR]

Two new cobalt(II)-acetato complexes, [CoII(L3NCOO)(OAc)]·0.5H2O (1OAc·0.5H2O) and [CoII(L4N)(OAc)](PF6) (2OAc(PF6)), were synthesised using ligands L3NCOO− (Li+L3NCOO− = lithium 2-(benzyl((6′-methyl-[2,2′-bipyridin]-6-yl)methyl)amino)acetate) and L4N (N-benzyl-1-(6′-methyl-[2,2′-bipyridin]-6-yl)-N-(pyridin-2-ylmethyl)methanamine), respectively, to mimic the functional activity of cobalt(II)-quercetin-2,4-dioxygenase (CoII-2,4-QD). Additionally, Co(II)-flavonolato ternary complexes, [CoII(L3NCOO)(fla)]·H2O (1fla·H2O) and [CoII(L4N)(fla)](PF6) (2fla(PF6)), were synthesised as enzyme–substrate models. All four complexes were thoroughly characterised by elemental analyses and spectroscopic methods. Structural characterisation was performed for 1OAc·0.5H2O, 2OAc(PF6)·CH2Cl2 and 2fla+ with a perchlorate counter anion, 2fla(ClO4)·1.5H2O. Furthermore, density functional theory (DFT) calculations, time-dependent DFT (TD-DFT) and molecular orbital (MO) analysis were performed for the flavonolato adducts 1fla and 2fla+. The catalytic activities of complexes 1OAc·0.5H2O and 2OAc(PF6) in the oxygenative degradation of flavonol (multiple-turnover reactions) were investigated at 70 °C in DMF to determine the effect of the carboxylate substituent over a pyridyl donor residue on reactivity. Complex 1OAc·0.5H2O showed a higher catalytic rate than complex 2OAc(PF6). The same reactivity order was observed for single-turnover dioxygenation reactions with ternary complexes (1fla > 2fla+). The formation constants (Kf) of 1fla and 2fla+ species are comparable, implying that catalyst–substrate adduct formation occurs in similar amounts for both catalytic reactions. Therefore, the Kf values have a similar impact on reactivities. However, the oxidation potential of the bound fla−/fla˙ couple in 1fla is considerably lower than that in 2fla+. DFT calculations predicted that the negatively charged carboxylate group of ligand L3NCOO− determines the higher reactivity of 1fla with dioxygen by decreasing the oxidation potential of the bound fla−/fla˙ couple. During the dioxygenation process, the reactive Co(II)-bound flavonoxy radical was generated via single-electron transfer from the coordinated fla− to dioxygen, simultaneously forming a superoxide ion. The anionic carboxylate group improves the stability of the bound flavonoxy radical by providing substantial electron density to the electron-deficient fla˙ through the Co(II) centre, allowing the reactive fla˙ species to accumulate at an optimal concentration for effective catalysis. EPR spectroscopy successfully detected the cobalt-bound fla˙ species formed through the dioxygenation of 1fla. NBT2+ and EPR spin-trapping experiments confirmed superoxide formation during the dioxygenation process. So, the present work describes CoII-2,4-QD model studies and clarifies the function of carboxylate in quercetinase-like reactivity. [ABSTRACT FROM AUTHOR]

Mental health is one of the most sensitive issues in today's complex world. This is because in this everchanging world, the practice of living a beautiful and happy life while maintaining good mental health is truly a great challenge. As the world seems to be getting easier, human life is getting more and more complicated. In such a context it is necessary to try to develop a balanced personality by thoroughly considering the issues of mental health. In such a context, positive psychology is especially helpful in keeping people energetic, optimistic and dynamic. Based on all these possibilities of positive psychology, this study seeks to illustrate its meaning and necessity and strategies in today's world order. Here the writers of this paper endeavour to discuss the concept, importance and strategies of positive psychology. [ABSTRACT FROM AUTHOR]

Every human being is deserved to live with dignity. It is one of the basic or fundamental aspirations of human being. In order to satisfy such basic concern of life, human rights are highly required. Now a day’s human right has become a topic of debate. Human right violation in different phases of life pause a great threat to the humanity in a sense [ABSTRACT FROM AUTHOR]

Using a potentially tridentate o-aminophenol-based redox-active ligand H2L1 (2-[2-(benzylthio)phenylamino]-4,6-di-tert-butylphenol) in its deprotonated form, [Cu(L1)2] has been synthesized and crystallized as [CuII(L1)2]·CH2Cl2 (1·CH2Cl2). A cyclic voltammetry experiment (in CH2Cl2; V vs. SCE (saturated calomel electrode)) on 1·CH2Cl2 exhibits two oxidative (E11/2 = 0.20 V (peak-to-peak separation, ΔEp = 100 mV) and E21/2 = 0.90 V (ΔEp = 140 mV)) and two reductive (E11/2 = −0.52 V (ΔEp = 110 mV) and E21/2 = −0.92 V (ΔEp = 120 mV)) responses. Upon oxidation using a stoichiometric amount of [FeIII(η5-C5H5)2](PF6), 1·CH2Cl2 yielded [Cu(L1)2](PF6) (2). Structural analysis (100 K) reveals that 1·CH2Cl2 is a four-coordinate bis(iminosemiquinonato)copper(ii) complex (CuN2O2 coordination), and that the thioethers remain uncoordinated. The twisted geometry of 1 (distorted tetrahedral) results in considerable changes in the electronic structure, compared to well-known square-planar analogues. Crystallographic analysis of 2 both at 100 K and at 293 K reveals that it is effectively a four-coordinate complex with a CuN2OS coordination; however, a substantial interaction with the other phenolate O is observed. The metal–ligand bond distances and metric parameters associated with the o-aminophenolate rings indicate a valence-tautomeric (VT) equilibrium involving monocationic (iminosemiquinonato)(iminoquinone)copper(ii) and bis(iminoquinone)copper(i). Complex 1·CH2Cl2 is a three-spin system and a magnetic study (4–300 K) established that it has a S = 1/2 ground-state, owing to the strong antiferromagnetic coupling between the unpaired spin of the copper(ii) and the iminosemiquinonate(1−) π-radical anion. Electron paramagnetic resonance (EPR) spectral studies corroborate this result. Complex 2 is diamagnetic and the existence of VT in 2 was probed using variable-temperature (248–328 K) 1H NMR and EPR (100–298 K) spectral measurements and X-ray photoelectron spectroscopic studies at 298 K. Remarkably, modification of the well-studied 2-anilino-4,6-di-tert-butylphenol by incorporation of a benzylthioether arm leads to the occurrence of VT in 2. The electronic structure of 1·CH2Cl2 and 2 has been assigned using density functional theory (DFT) calculations at the B3LYP-D3 level of theory. Time-dependent (TD)-DFT calculations have been performed to elucidate the origin of the observed UV-VIS-NIR absorptions. [ABSTRACT FROM AUTHOR]

Aerobic reaction of the ligand H2L1, 2-(2-phenylazo)-anilino-4,6-di-tert-butylphenol, CoCl2·6H2O and Et3N in MeOH under refluxing conditions produces, after work-up and recrystallization, black crystals of [Co(L1)2] (1). When examined by cyclic voltammetry, 1 displays in CH2Cl2 three one-electron redox responses: two oxidative, E11/2 = 0.30 V (peak-to-peak separation, ΔEp = 100 mV) and E21/2 = 1.04 V (ΔEp = 120 mV), and one reductive E1/2 = −0.27 V (ΔEp = 120 mV) vs. SCE. Consequently, 1 is chemically oxidized by 1 equiv. of [FeIII(η5-C5H5)2][PF6], affording the isolation of deep purple crystals of [Co(L1)2][PF6]·2CH2Cl2 (2), and one-electron reduction with [CoII(η5-C5H5)2] yielded bluish-black crystals of [CoIII(η5-C5H5)2][Co(L1)2]·MeCN (3). A solid sample of 1 exhibits temperature-independent (50–300 K) magnetism, revealing the presence of a free radical (S = 1/2), which exhibits an isotropic EPR signal (g = 2.003) at 298 K and at 77 K an eight-line feature characteristic of hyperfine-interaction of the radical with the Co (I = 7/2) nucleus. Based on X-ray structural parameters of 1–3 at 100 K, magnetic and EPR spectral behaviour of 1, and variable-temperature (233–313 K) 1H NMR spectral features of 1–3 and 13C NMR spectra at 298 K of 2 and 3 in CDCl3 point to the electronic structure of the complexes as either [CoIII{(LAP)2−}{(LISQ)}Ṗ−] or [CoIII{(L1)2}Ṗ3−] (delocalized nature favours the latter description) (1), [CoIII{(LISQ)Ṗ−}2][PF6]·2CH2Cl2 (2) and [CoIII(η5-C5H5)2][CoIII{(LAP)2−}2]·MeCN (3) [(LAP)2− and (LISQ)Ṗ− represent the redox-level of coordinated ligands o-amidophenolate(2−) ion and o-iminobenzosemiquinonate(1−) π-radical ion, respectively]. Notably, all the observed redox processes are ligand-centred. To the best of our knowledge, this is the first time that six-coordinate complexes of a common tridentate o-aminophenolate-based ligand have been structurally characterized for the parent 1, its monocation 2 and the monoanion 3 counterparts. Temperature-dependent 1H NMR spectra reveal the existence of valence-tautomeric equilibria in 1–3. Density Functional Theory (DFT) calculations at the B3LYP-level of theory corroborate the electronic structural assignment of 1–3 from experimental data. The origins of the observed UV–VIS–NIR absorptions for 1–3 have been assigned, based on time-dependent (TD)-DFT calculations. [ABSTRACT FROM AUTHOR]