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1,337 results on '"Barker, Alan"'

5. Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months

Author

Haworth, Charles S, Shteinberg, Michal, Winthrop, Kevin, Barker, Alan, Blasi, Francesco, Dimakou, Katerina, Morgan, Lucy C, O'Donnell, Anne E, Ringshausen, Felix C, Sibila, Oriol, Thomson, Rachel M, Carroll, Kevin J, Pontenani, Federica, Castellani, Paola, and Chalmers, James D

Published
2024
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7. Calibration and Cross-Validation of Accelerometry in Children and Adolescents with Cystic Fibrosis

Author

Bianchim, Mayara S., McNarry, Melitta A., Evans, Rachel, Thia, Lena, Barker, Alan R., Williams, Craig A., Denford, Sarah, and Mackintosh, Kelly A

Abstract

Commonly used cut-points may misclassify physical activity (PA) in people with cystic fibrosis (CF). The aim of this study was to develop and cross-validate condition-specific cut-points in children and adolescents with CF. Thirty-five children and adolescents with CF (15 girls; 11.6 ± 2.8 years) and 28 controls (16 girls; 12.2 ± 2.7 years), had their energy expenditure and triaxial acceleration measured during six daily activities of varying intensities. Euclidean Norm Minus One (ENMO) and Mean Amplitude Deviation (MAD) were extracted using both GENEActiv (both wrists) and ActiGraph GT9X (both wrists and right waist) accelerometers. ROC curves were used to determine healthy and CF-specific raw acceleration cut-points for sedentary time (SED), moderate physical activity (MPA) and vigorous physical activity (VPA). The PA cut-points were generally lower in CF compared to controls for both ENMO (60.2-73.1 vs. 63.5-86.8 mg) and MAD (58.9-85.2 vs. 75.9-93.7 mg). These substantial inter-cut-point differences support the need for disease-specific cut-points.

Published
2023
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16. Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations

Author

Aliberti, Stefano, Goeminne, Pieter C, O'Donnell, Anne E, Aksamit, Timothy R, Al-Jahdali, Hamdan, Barker, Alan F, Blasi, Francesco, Boersma, Wim G, Crichton, Megan L, De Soyza, Anthony, Dimakou, Katerina E, Elborn, Stuart J, Feldman, Charles, Tiddens, Harm, Haworth, Charles S, Hill, Adam T, Loebinger, Michael R, Martinez-Garcia, Miguel Angel, Meerburg, Jennifer J, Menendez, Rosario, Morgan, Lucy C, Murris, Marlene S, Polverino, Eva, Ringshausen, Felix C, Shteinberg, Michal, Sverzellati, Nicola, Tino, Gregory, Torres, Antoni, Vandendriessche, Thomas, Vendrell, Montserrat, Welte, Tobias, Wilson, Robert, Wong, Conroy A, and Chalmers, James D

Published
2022
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19. Five-Year Outcomes Among U.S. Bronchiectasis and Nontuberculous Mycobacterial Registry Patients

Author

Aksamit, Timothy R, primary, Locantore, Nicholas, additional, Addrizzo-Harris, Doreen, additional, Ali, Juzar, additional, Barker, Alan, additional, Basavaraj, Ashwin, additional, Behrman, Megan, additional, Brunton, Amanda E, additional, Chalmers, Sarah, additional, Choate, Radmila, additional, Dean, Nathan C, additional, DiMango, Angela, additional, Fraulino, David, additional, Johnson, Margaret M., additional, Lapinel, Nicole C., additional, Maselli, Diego J, additional, McShane, Pamela J, additional, Metersky, Mark L, additional, Miller, Bruce E, additional, Naureckas, Edward T, additional, O'Donnell, Anne E., additional, Olivier, Kenneth N., additional, Prusinowski, Elly, additional, Restrepo, Marcos I, additional, Richards, Christopher J, additional, Rhyne, Gloria, additional, Schmid, Andreas, additional, Solomon, George M, additional, Tal-Singer, Ruth, additional, Thomashow, Byron, additional, Tino, Gregory, additional, Tsui, Kevin, additional, Varghese, Sumith Abraham, additional, Warren, Heather E., additional, Winthrop, Kevin, additional, and Zha, Beth Shoshanna, additional

Published
2024
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23. Pseudomonas aeruginosa associated with severity of non-cystic fibrosis bronchiectasis measured by the modified bronchiectasis severity score (BSI) and the FACED: The US bronchiectasis and NTM Research Registry (BRR) study

Author

Choate, Radmila, Aksamit, Timothy R., Mannino, David, Addrizzo-Harris, Doreen, Barker, Alan, Basavaraj, Ashwin, Daley, Charles L., Daniels, M. Leigh Anne, Eden, Edward, DiMango, Angela, Fennelly, Kevin, Griffith, David E., Johnson, Margaret M., Knowles, Michael R., McShane, Pamela J., Metersky, Mark L., Noone, Peadar G., O'Donnell, Anne E., Olivier, Kenneth N., Salathe, Matthias A., Schmid, Andreas, Thomashow, Byron, Tino, Gregory, Winthrop, Kevin L., and Stone, Glenda

Published
2021
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24. Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosainfection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months

Author

Haworth, Charles S, Shteinberg, Michal, Winthrop, Kevin, Barker, Alan, Blasi, Francesco, Dimakou, Katerina, Morgan, Lucy C, O'Donnell, Anne E, Ringshausen, Felix C, Sibila, Oriol, Thomson, Rachel M, Carroll, Kevin J, Pontenani, Federica, Castellani, Paola, and Chalmers, James D

Abstract

Chronic lung infection with Pseudomonas aeruginosais associated with increased exacerbations and mortality in people with bronchiectasis. The PROMIS-I and PROMIS-II trials investigated the efficacy and safety of 12-months of inhaled colistimethate sodium delivered via the I-neb.

Published
2024
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25. Five-Year Outcomes among U.S. Bronchiectasis and NTM Research Registry Patients.

Author

Aksamit, Timothy R., Locantore, Nicholas, Addrizzo-Harris, Doreen, Ali, Juzar, Barker, Alan, Basavaraj, Ashwin, Behrman, Megan, Brunton, Amanda E., Chalmers, Sarah, Choate, Radmila, Dean, Nathan C., DiMango, Angela, Fraulino, David, Johnson, Margaret M., Lapinel, Nicole C., Maselli, Diego J., McShane, Pamela J., Metersky, Mark L., Miller, Bruce E., and Naureckas, Edward T.

Subjects
MEDICAL registries, ASTHMATICS, PROPORTIONAL hazards models, BRONCHIECTASIS, BODY mass index
Abstract

Rationale: Nontuberculous mycobacteria (NTM) are prevalent among patients with bronchiectasis. However, the long-term natural history of patients with NTM and bronchiectasis is not well described. Objectives: To assess the impact of NTM on 5-year clinical outcomes and mortality in patients with bronchiectasis. Methods: Patients in the Bronchiectasis and NTM Research Registry with ⩾5 years of follow-up were eligible. Data were collected for all-cause mortality, lung function, exacerbations, hospitalizations, and disease severity. Outcomes were compared between patients with and without NTM at baseline. Mortality was assessed using Cox proportional hazards models and the log-rank test. Measurements and Main Results: In total, 2,634 patients were included: 1,549 (58.8%) with and 1,085 (41.2%) without NTM at baseline. All-cause mortality (95% confidence interval) at Year 5 was 12.1% (10.5%, 13.7%) overall, 12.6% (10.5%, 14.8%) in patients with NTM, and 11.5% (9.0%, 13.9%) in patients without NTM. Independent predictors of 5-year mortality were baseline FEV1 percent predicted, age, hospitalization within 2 years before baseline, body mass index, and sex (all P < 0.01). The probabilities of acquiring NTM or Pseudomonas aeruginosa were approximately 4% and 3% per year, respectively. Spirometry, exacerbations, and hospitalizations were similar, regardless of NTM status, except that annual exacerbations were lower in patients with NTM (P < 0.05). Conclusions: Outcomes, including exacerbations, hospitalizations, rate of loss of lung function, and mortality rate, were similar across 5 years in patients with bronchiectasis with or without NTM. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Accelerometer‐based sedentary time, light physical activity, and moderate‐to‐vigorous physical activity from childhood with arterial stiffness and carotid IMT progression: A 13‐year longitudinal study of 1339 children.

Author

Agbaje, Andrew O., Barker, Alan R., Lewandowski, Adam J., Leeson, Paul, and Tuomainen, Tomi‐Pekka

Subjects
*ARTERIAL diseases, *PHYSICAL activity, *CAROTID intima-media thickness, *PULSE wave analysis, *LONGITUDINAL method
Abstract

Aims: We examined the longitudinal associations of sedentary time (ST), light physical activity (LPA), and moderate‐to‐vigorous PA (MVPA) from childhood with carotid‐femoral pulse wave velocity (cfPWV), a measure of arterial stiffness and carotid intima‐media thickness (cIMT). Methods: We studied 1339 children, aged 11 years from Avon Longitudinal Study of Parents and Children, UK, followed up for 13 years. Accelerometer‐based ST, LPA, and MVPA were assessed at ages 11, 15, and 24 years clinic visits. cfPWV and cIMT were measured with Vicorder and ultrasound, respectively, at ages 17 and 24 years. Results: Among 1339 [56.4% female] participants, mean ST increased from ages 11 through 24 years, while mean LPA and MVPA decreased. Persistently high ST tertile from childhood was associated with increased cfPWV progression, effect estimate 0.047 m/s; [(95% CI 0.005 to 0.090); p = 0.030], but not cIMT progression. Persistently high LPA tertile category was associated with decreased cfPWV progression in males −0.022 m/s; [(−0.028 to −0.017); p < 0.001] and females −0.027 m/s; [(−0.044 to −0.010); p < 0.001]. Cumulative LPA exposure decreased the odds of progressively worsening cfPWV [Odds ratio 0.994 (0.994–0.995); p < 0.0001] and cIMT. Persistent exposure to ≥60 min/day of MVPA was paradoxically associated with increased cfPWV progression in males 0.053 m/s; [(0.030 to 0.077); p < 0.001] and females 0.012 m/s; [(0.002 to 0.022); p = 0.016]. Persistent exposure to ≥60 min/day of MVPA was inversely associated with cIMT progression in females −0.017 mm; [(−0.026 to −0.009); p < 0.001]. Conclusion: LPA >3 h/day from childhood may attenuate progressively worsening vascular damage associated with increased ST in youth. [ABSTRACT FROM AUTHOR]

Published
2024
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27. The Role of Diet in the Cardiovascular Health of Childhood Cancer Survivors—A Systematic Review.

Author

Li, Ruijie, Barker, Alan R., Vlachopoulos, Dimitris, Paris, Dewi, Schindera, Christina, Belle, Fabiën N., and Revuelta Iniesta, Raquel

Abstract

Background: Childhood cancer survivors (CCSs) face an increased risk of cardiovascular disease (CVD). This systematic review aims to provide the first synthesis of observational and interventional studies on the relationship between diet and cardiovascular health in CCSs. Methods: A comprehensive search was conducted for studies published between 1990 and July 2023 in PubMed, MEDLINE, CINAHL, Child Development & Adolescent Studies, and Cochrane Library. Eligible studies included observational and interventional studies examining the associations or effects of dietary factors on CVD incidence, cardiac dysfunction, or CVD risk factors in CCSs diagnosed before age 25 years. Results: Ten studies met the inclusion criteria (nine observational and one interventional). Collectively, they comprised 3485 CCSs (male, 1734; female, 1751). The outcomes examined across observational studies included characteristics of obesity, diabetes biomarkers, hypertension indicators, dyslipidaemia biomarkers, and metabolic syndrome. The evidence suggested that greater adherence to healthy diets was associated with lower body mass index, blood pressure, glucose, and triglycerides and higher high-density lipoprotein cholesterol. The 12-week lifestyle intervention study in childhood leukaemia survivors found no impact on obesity indicators. Conclusion: The review results indicate the potentially protective effects of healthy diets. However, the available research remains preliminary and limited, underscoring the need for more rigorous, adequately powered studies. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Airway Clearance Techniques in Bronchiectasis: Analysis From the United States Bronchiectasis and Non-TB Mycobacteria Research Registry

Author

Basavaraj, Ashwin, Choate, Radmila, Addrizzo-Harris, Doreen, Aksamit, Timothy R., Barker, Alan, Daley, Charles L., Anne Daniels, M. Leigh, Eden, Edward, DiMango, Angela, Fennelly, Kevin, Griffith, David E., Johnson, Margaret M., Knowles, Michael R., Metersky, Mark L., Noone, Peadar G., O’Donnell, Anne E., Olivier, Kenneth N., Salathe, Matthias A., Schmid, Andreas, Thomashow, Byron, Tino, Gregory, and Winthrop, Kevin L.

Published
2020
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30. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molassoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., and Ireland, Belinda

Published
2020
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31. Managing Chronic Cough Due to Asthma and NAEB in Adults and Adolescents: CHEST Guideline and Expert Panel Report

Author

Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lane, Andrew P., Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Côté, Andreanne, Boulet, Louis-Philippe, Gibson, Peter G., and Brightling, Christopher E.

Published
2020
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32. Acute Cough Due to Acute Bronchitis in Immunocompetent Adult Outpatients: CHEST Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Blackhall, Fiona, Birring, Surinder S., Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lilly, Craig, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Ireland, Belinda, and Linder, Jeffrey A.

Published
2020
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36. Chronic Cough and Gastroesophageal Reflux in Children: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Bolser, Donald C., Birring, Surinder S., Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Harding, Susan M., Gold, Philip, Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Lai, Kefang, Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Metlay, Joshua P., Molasoitis, Alex, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Weinberger, Miles, Oppenheimer, John J., Kantar, Ahmad, and Rubin, Bruce K.

Published
2019
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40. Clinically Diagnosing Pertussis-associated Cough in Adults and Children: CHEST Guideline and Expert Panel Report

Author

Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Bolser, Donald C., Birring, Surinder S., Blackwell, Fiona, Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Grant, Cameron, Gibson, Peter, Gold, Philip, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Lown, Mark, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Vertigan, Anne E., Weinberger, Miles, Grant, Cameron C., and Patel, Sheena

Published
2019
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41. Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza: CHEST Guideline and Expert Panel Report

Author

Adams, Todd M., Altman, Kenneth W., Azoulay, Elie, Barker, Alan F., Birring, Surinder S., Blackhall, Fiona, Bolser, Donald C., Boulet, Louis-Philippe, Braman, Sidney S., Brightling, Christopher, Callahan-Lyon, Priscilla, Chang, Anne B., Cowley, Terrie, Davenport, Paul, El Solh, Ali A., Escalante, Patricio, Field, Stephen K., Fisher, Dina, French, Cynthia T., Gibson, Peter, Gold, Philip, Grant, Cameron, Harding, Susan M., Harnden, Anthony, Hill, Adam T., Irwin, Richard S., Kahrilas, Peter J., Kavanagh, Joanne, Keogh, Karina A., Lai, Kefang, Lane, Andrew P., Lim, Kaiser, Madison, J. Mark, Malesker, Mark A., Mazzone, Stuart, McGarvey, Lorcan, Molasoitis, Alex, Moore, Abigail, Murad, M. Hassan, Narasimhan, Mangala, Newcombe, Peter, Nguyen, Huong Q., Oppenheimer, John, Rosen, Mark, Rubin, Bruce, Russell, Richard J., Ryu, Jay H., Singh, Sonal, Smith, Jaclyn, Smith, Maeve P., Tarlo, Susan M., Turmel, Julie, Vertigan, Anne E., Wang, Gang, Weinberger, Miles, Gold, Philip M., Metlay, Joshua P., and Ireland, Belinda

Published
2019
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43. A Machine Learning Approach for Physical Activity Recognition in Cystic Fibrosis.

Author

Bianchim, Mayara S., McNarry, Melitta A., Barker, Alan R., Williams, Craig A., Denford, Sarah, Thia, Lena, Evans, Rachel, and Mackintosh, Kelly A

Subjects
PULMONARY function tests, MEDICAL protocols, PREDICTION models, RESEARCH funding, ACCELEROMETERS, RESEARCH methodology evaluation, RESEARCH evaluation, ACTIGRAPHY, DESCRIPTIVE statistics, MACHINE learning, PHYSICAL activity, CYSTIC fibrosis, SENSITIVITY & specificity (Statistics)
Abstract

This study aimed to develop and validate machine learning models to predict intensities in children and adolescents with cystic fibrosis (CF) across different accelerometry brands and placements. Thirty-five children and adolescents with CF (11.6 ± 2.8 yrs; 15 girls) and 28 healthy youth (12.2 ± 2.7 yrs; 16 girls) performed six activities whilst wearing GENEActivs (both wrists) and ActiGraphs GT9X (both wrists and waist). Three supervised learning classifiers (K-Nearest Neighbour, Random Forest and eXtreme Gradient Boosted Decision Tree) were used to identify the input signal pattern for each PA type and intensity, with a 10-fold cross-validation utilized to assess the performance of the classifiers. ActiGraph GT9X on the dominant wrist and waist and GENEActiv on the dominant wrist failed to predict vigorous intensity PA activities. All other models, for activity type and intensities, exceeded 97% accuracy, with a sensitivity and specificity of greater than 95%, irrespective of accelerometer brand, placement or health condition. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Absence

Author

Barker, Alan

Published
1982

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