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Solubility enhancement of poorly aqueous-soluble drugs, like Terbinafine (TBN), is a critical challenge in formulating effective dosage forms. This study focused on developing β-cyclodextrin (β-CD) and polyacrylamide (PAM)-based microgels to address the solubility issue of TBN, classified as a biopharmaceutics classification system class II drug. The microgels were crafted through free radical polymerization, employing methylene bisacylamide as a cross-linker and methacrylic acid as a monomer, initiated by ammonium persulfate. Comprehensive characterizations, including Fourier transform infrared, thermo-gravimetric analysis, differential scanning calorimetry, scanning electron microscopy, powder X-ray diffractometry analysis, Zeta size, and Zeta potential, were conducted. In vitro studies, such as drug release and swelling, were performed at pH 1.2. Toxicity analysis in rabbits revealed zero toxicity. These β-CD/PAM microgels successfully enhanced the solubility of TBN.

In recent years, Piezoelectric Transformers (PTs) have become a great success due to their excellent properties, especially in applications requiring high voltage. The Rosen-type PT is well known for this performance, as its voltage gain at the resonant frequency can reach few thousands. However, the high output impedance of this device can make an accurate electrical measurement of the output voltage difficult, hence the need to ensure good impedance matching along the measuring electrical test setup. For this purpose, two high impedance oscilloscope probes were successively added to the secondary side to further emulate the measurement chain and match the experiments as closely as possible with the developed 1D model. Accordingly, for an unloaded Rosen type piezoelectric transformer, made of hard ceramic (pz26) with corresponding dimensions 2L×w×t =25 mm×3 mm×2 mm and operating in the first three modes, the corresponding input impedances Zin were evaluated at 665 Ω - 225 Ω and 1974 Ω, while the output impedances Zout were evaluated at 19.2 MΩ - 15.4 MΩ, and 1.8 MΩ. A voltage gain of 164, 179 and 23 at frequencies of 69.4 kHz, 136 kHz and 204.6 kHz, respectively was successfully measured, with a precision of less than 5%. In addition, a detailed equivalent circuit of the transformer was built and all its lumped RLC components were experimentally identified using the Nyquist diagram showing, on the whole, a well-accepted agreement with the expected results.

This study aimed to determine the appropriate timing for substituting live feed with artificial feed in the rearing of Channa striata larvae. The larvae at the age of 2 days after hatching (DAH) with an average initial length and weight of 6.27 ± 0.88 mm and 0.53 ± 0.01 mg, respectively, were used as the experimental biota. Larvae were randomly distributed into 16 containers, with a stocking density of 350 individuals per container. The study was conducted with four treatments, each with four replications. The larvae were co-fed Moina sp. and artificial feed at 6, 8, 10, and 12 DAH with a reduction of Moina sp. starting from 0.5% to 5.0%. The measured parameters showed the most favorable results when initiating artificial feeding at 12 DAH with survival rate of 89.52 ± 4.49%, and specific growth rate of 15.67 ± 0.25% per day with artificial feed conversion ratio of 51.79 ± 0.09. The enzyme activity and intestinal histology showed the effect of the co-feeding regime on intestinal development. Finally, the present study revealed that the weaning period for C. striata larvae could be conducted at 12–16 DAH and artificial feeding may be implemented at 17 DAH.

The vocational training and education sector in Algeria faces numerous challenges due to its roles in both economic and social spheres. Therefore, this study aims to determine the extent of outstanding performance management practices in vocational training institutions in the state of Médéa, Algeria. The quantitative analytical approach was used on a sample of 21 vocational training institutions, relying on the questionnaire as a data collection tool, which was distributed to 51 (institution directors, sub-directors, and heads of departments). The study reached several results, the most important of which is the application of outstanding performance management in the studied institutions, where it was proven that the dimensions of performance management exist, and the institutions’ application of performance planning and feedback was at a high level. As for the institution’s application of the dimension of improving and developing performance and after measuring and evaluating performance, there was a medium level of application.

Abstract The aim of our study was to evaluate if the response to follicular GnRH agonist (GnRHa) trigger be used to predict intracycle ovarian response in GnRH antagonist cycles among women undergoing fertility preservation IVF. We conducted a prospective study of 146 GnRH antagonist oocyte pickup (OPU) cycles to evaluate GnRHa stimulation test (GAST). On day 2 of the cycle, basal E2 were measured, followed by injection of 0.2 mg GnRHa as part of the initial ovarian stimulation. 12 h later blood sampling was repeated (GAST E3). E2 response was used as test parameter. The major outcome was the number of mature cryopreserved oocytes. We found a linear correlation between both GAST E3 level and GAST E3/E2 ratio and number of M2 oocytes. ROC curve analysis of GAST E3, GAST E3/E2 ratio, AFC and day 3 FSH for > 15 M2 and 15 M2 oocytes, AUC value of 0.8. Patients with GAST E3 ≤ 384 pmol/l has 58.6% risk to obtain 708 pmol/l have 66% chance for freezing > 15 oocytes. The response to single GnRHa administration during GnRH antagonist cycle can be used as biomarker of ovarian reserve. This simple, widely available marker, which reflect the estradiol response of small follicles, might predict the response of the specific cycle, and can potentially be used to adjust the treatment dose. Trial registration number: 0304-20-ASF.

Vaccine development requires high-resolution, in situ, and visual adjuvant technology. To address this need, this work proposed a novel adjuvant labeling that involved indocyanine green (ICG) and bovine serum albumin (BSA) with self-assembled aluminium adjuvant (Alum), which was called BSA@ICG@Alum. This compound exhibited excellent photoacoustic properties and has been confirmed its safety, biocompatibility, high antigen binding efficiency, and superior induction of immune response. Photoacoustic tomography (PAT) tracked the distribution of Alum in lymph nodes (LNs) and lymphatic vessels in real time after diverse injection modalities. The non-invasive imaging approach revealed that BSA@ICG@Alum was transported to the draining LNs 60 min after intramuscular injection and to distal LNs within 30 min after lymph node injection. In conclusion, PAT enabled real-time three-dimensional and quantitative visualization, thus offering a powerful tool for advancing vaccine design by providing critical insights into adjuvant transport and immune system activation.