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3. Childhood Langerhans cell histiocytosis hematological involvement: severity associated with BRAFV600E loads

Author

Thalhammer, Julian, Jeziorski, Eric, Marec-Bérard, Perrine, Barkaoui, Mohamed, Pagnier, Anne, Rohrlich, Pierre-Simon, Chevallier, Aurore, Carausu, Liana, Aladjidi, Nathalie, Rigaud, Charlotte, Leruste, Amaury, Azarnoush, Saba, Lauvray, Thomas, Le Louet, Solenne, Gandemer, Virginie, Treguier, Pauline, Mansuy, Ludovic, Pasquet, Marlene, Olivier, Laura, Rome, Angélique, Saultier, Paul, Isfan, Fiorentina, Renard, Cécile, Thiao, Valerie Li, Salmon, Alexandra, Blanc, Laurence, Chahla, Wadih Abou, Lambilliotte, Anne, Stephan, Jean-Louis, Geissmann, Frederic, Lejeune, Julien, Mallebranche, Coralie, Reguerre, Yves, Grain, Audrey, Thomas, Caroline, Hélias-Rodzewicz, Zofia, Moshous, Despina, Fenneteau, Odile, Coulomb-L’Hermine, Aurore, Lapillonne, Hélène, de Saint-Basile, Geneviève, Emile, Jean-François, Héritier, Sébastien, and Donadieu, Jean

Published
2024
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4. Lung transplantation as a rescue option in childhood critical pulmonary Langerhans cell histiocytosis

Author

Heritier, Sébastien, primary, Donadieu, Jean, additional, Leger, Pierre‐Louis, additional, De Tersant, Marie, additional, Della Vallee, Valeria, additional, Barkaoui, Mohamed‐Aziz, additional, Le Louet, Solenne, additional, Tazi, Abdellatif, additional, Taytard, Jessica, additional, Corvol, Harriet, additional, Helias‐Rodzevicz, Zofia, additional, Emile, Jean‐François, additional, Fadel, Elie, additional, Fabre, Dominique, additional, Feuillet, Séverine, additional, and Nathan, Nadia, additional

Published
2023
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6. Childhood Langerhans cell histiocytosis with severe lung involvement: a nationwide cohort study

Author

Le Louet, Solenne, Barkaoui, Mohamed-Aziz, Miron, Jean, Galambrun, Claire, Aladjidi, Nathalie, Chastagner, Pascal, Kebaili, Kamila, Armari-Alla, Corinne, Lambilliotte, Anne, Lejeune, Julien, Moshous, Despina, Della Valle, Valeria, Sileo, Chiara, Ducou Le Pointe, Hubert, Chateil, Jean-François, Renolleau, Sylvain, Piloquet, Jean-Eudes, Portefaix, Aurelie, Epaud, Ralph, Chiron, Raphaël, Bugnet, Emmanuelle, Lorillon, Gwenaël, Tazi, Abdelatif, Emile, Jean-François, Donadieu, Jean, and Héritier, Sébastien

Published
2020
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9. Gender and Body Mass Index Difference in Aerobic Capacity: A Study in Moroccan High School Students.

Author

Benchelha, Hassan, Chakit, Miloud, Mouilly, Mustapha, Nadir, Karim, Barkaoui, Mohamed, Moustaine, Abdelhak, Elkhatir, Abdelkarim, Ahami, Ahmed O. T., and Bikjdaouene, Leila

Subjects
AEROBIC capacity, EXERCISE tests, BODY weight, RUNNING, CHILDHOOD obesity, OXYGEN consumption, SEX distribution, PHYSIOLOGICAL effects of acceleration, HEART rate monitoring, EXERCISE, DESCRIPTIVE statistics, BODY mass index, HIGH school students
Abstract

Different tests are used to evaluate the aerobic capacity of a person. This study aims to investigate the gender and Body Mass Index (BMI) difference in aerobic capacity measured by using shuttle and Spartacus test. The study was conducted on 230 high school students (135 girls and 95 boys) followed their study in public establishment in kenitra city (Morocco). All participants were classified according to their gender (male vs. female) and their BMI (normal weight vs. overweight-obese) and performed the both test of shuttle and Spartacus. Running speed at the last completed stage, run time, maximum heart rate (max HR) max HR and perceived exertion were measured and analyzed. For each test, VO2max was estimated by using the proposed equation. There was significant BMI difference in the measured parameters (p<0.001). Difference in VO2max between male and female remained significant with high-speed level in boys. A significant difference between males and females (p < 0.001) was observed in shuttle test. Participants with normal weight or physical activity had good aerobic capacity. Compared to the Shuttle test, the Spartacus provides a 11.5% higher final speed (11.2 vs. 9.7km/h) and a total test time 2.3 times longer (11.3vs. 4.9 min) (p < 0.001). Our study underlines the interest of the Spartacus test and is preliminary. Indeed, these results must now be replicated in a larger sample of obese adolescents [ABSTRACT FROM AUTHOR]

Published
2023
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11. Molecular and clinicopathologic characterization of pediatric histiocytoses

Author

HELIAS-RODZEWICZ, Z, DONADIEU, Jean, TERRONES, Nathalie, BARKAOUI, Mohamed-Aziz, LAMBILLIOTTE, ANNE, MOSHOUS, DESPINA, Thomas, Caroline, AZAMOUSH, SABA, PASQUET, MARLENE, MANSUY, LUDOVIC, ALADJIDI, NATHALIE, JEZIORSKI, ERIC, MAREC-BERARDF, PERRINE, GILIBERT-YVET, MARION, SPIEGEL, ALEXANDRA, SAULTIER, PAUL, PELLIER, ISABELLE, PAGNIER, ANNE, PERTUISEL, SOPHIE, POIREE, MARYLINE, BODET, DAMIEN, MILLOT, FREDERIC, IFSAN, FLORENTINA, STEPHANN, JEAN-LOUIS, LERUSTRE, AMAURY, RIGAUD, CHARLOTTE, FILHON, BRUNO, CARAUSU, LIANA, REGUERRE, YVES, KIEFFER, ISABELLE, Brichard, Bénédicte, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, and UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique

Abstract

Molecular and clinicopathologic characterization of pediatric histiocytoses.

Published
2023

16. A Hybrid Genetic Algorithm for the Capacitated Vehicle Routing Problem

Author

Berger, Jean, Barkaoui, Mohamed, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Cantú-Paz, Erick, editor, Foster, James A., editor, Deb, Kalyanmoy, editor, Davis, Lawrence David, editor, Roy, Rajkumar, editor, O’Reilly, Una-May, editor, Beyer, Hans-Georg, editor, Standish, Russell, editor, Kendall, Graham, editor, Wilson, Stewart, editor, Harman, Mark, editor, Wegener, Joachim, editor, Dasgupta, Dipankar, editor, Potter, Mitch A., editor, Schultz, Alan C., editor, Dowsland, Kathryn A., editor, Jonoska, Natasha, editor, and Miller, Julian, editor

Published
2003
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17. Molecular and clinicopathologic characterization of pediatric histiocytoses.

Author

Hélias‐Rodzewicz, Zofia, Donadieu, Jean, Terrones, Nathalie, Barkaoui, Mohamed‐Aziz, Lambilliotte, Anne, Moshous, Despina, Thomas, Caroline, Azarnoush, Saba, Pasquet, Marlène, Mansuy, Ludovic, Aladjidi, Nathalie, Jeziorski, Eric, Marec‐Berard, Perrine, Gilibert‐Yvert, Marion, Spiegel, Alexandra, Saultier, Paul, Pellier, Isabelle, Pagnier, Anne, Pertuisel, Sophie, and Poiree, Maryline

Published
2023
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18. Cas du Maroc

Author

Koutaya, Ayoub, Eloirdi, Aziz, Barkaoui, Mohamed, Marfouq, Assia, Koutaya, Younes, and Eloirdi, Hamid

Subjects
physical and sports education, learning, technopédagogie, innovation pédagogique, Distance education, pedagogical innovation, apprentissage, technopedagogy, enseignement à distance, Geography, éducation physique et sportive, distance education, Papers, Mathematics education
Abstract

Distance training or distance learning has experienced a boom in recent years in several regions of the world. It follows from this interest that the emergence of distance learning has been remarkably advocated by higher education institutions and less and less at the secondary and college levels where face-to-face training is becoming essential. However, during the period of health crisis due to Covid-19, distance education had established itself as a new alternative mode for face-to-face education for all levels of education, and for all subjects combined. Physical and sports education (PSE) is no exception to this change. In this context, the discipline EPS has sparked a debate on the modalities of engagement of teachers of EPS to participate in distance education given the almost practical nature of the subject. Faced with this problem, EPS teachers (high school and college) found themselves forced to formalize educational content and transmit it on various media. This study contributes to the identification of the degree of commitment of PE teachers to ensure the sustainability of learning and to determine the obstacles encountered in this operation qualified as urgent. This study saw the participation of 166 teachers in two levels of secondary and college education through three regional academies in Morocco. The results showed both the lack of communication between the inspectors of the EPS and the teachers of the subject, and the coordination between the teachers within the teaching units. &nbsp, La formation à distance ou l’apprentissage à distance connait son plein essor ces dernières années dans plusieurs régions du monde. Il résulte de cet intérêt que l’émersion de l’apprentissage à distance a été remarquablement prôné par les établissements d’enseignement supérieur et de moins en moins au niveau secondaire et collégial où la formation en présentiel devient essentielle. Cependant, pendant la période de crise sanitaire à cause du Covid-19, l’enseignement à distance s’était imposé comme un nouveau mode alternatif pour le présentiel pour tous les niveaux d’enseignement, et pour toutes les matières confondues. L’éducation physique et sportive (EPS) n’échappe pas à ce changement. Dans ce contexte, la discipline EPS a suscité un débat sur les modalités d’engagement des professeurs d’EPS pour participer à l’enseignement à distance vu la nature quasiment pratique de la matière. Devant ce problème, les enseignants d’EPS (lycée et collège) se sont trouvés contraint de formaliser des contenus pédagogiques et de les transmettre sur différents supports médiatiques. Cette étude contribue à l’identification du degré d’engagement des enseignants d’EPS pour assurer la durabilité des apprentissages et de déterminer les entraves rencontrées dans cette opération qualifiée d’urgente. Cette étude a vu la participation de 166 enseignants dans deux niveaux d’enseignements secondaire et collégial à travers trois académies régionales au Maroc. Les résultats ont montré à la fois l’absence de la communication entre les inspecteurs de l’EPS et les professeurs de la matière, et la coordination entre les professeurs au sein des unités pédagogiques. &nbsp

Published
2020
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19. Profil épidémiologique, aspects diagnostiques et évolutifs des patients tuberculeux au centre de diagnostic de la tuberculose et des maladies respiratoires de Settat, Maroc

Author

Chahboune, Mohamed, primary, Barkaoui, Mohamed, additional, Iderdar, Younes, additional, Alwachami, Nadia, additional, Mourajid, Yassmine, additional, Ifleh, Mohamed, additional, Boumendil, Karima, additional, Bachar, Khadija, additional, and El Madani, Saad, additional

Published
2022
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20. Hematological Involvement in Childhood Langerhans Cell Histiocytosis: A Cohort Study of 303 Patients

Author

Thalhammer, Julian, Marec-Bérard, Perrine, Barkaoui, Mohamed, Jeziorski, Eric, Rome, Angelique, Pagnier, Anne, Rohrlich, Pierre Simon, Aladjidi, Nathalie, Rigaud, Charlotte, Leruste, Amaury, Azarnoush, Saba, Lauvray, Thomas, Le Louet, Solenne, Gandemer, Virginie, Treguier, Pauline, Mansuy, Ludovic, Pasquet, Marlène, Olivier, Laura, Isfan, Florentina, Renard, Cécile, Salmon, Alexandra, Blanc, Laurence, Abou Chahla, Wadih, Lambilliotte, Anne, Mallebranche, Coralie, Thomas, Caroline, Moshous, Despina, de Saint-Basile, Genevieve, Emile, Jean-Francois, Héritier, Sébastien, and Donadieu, Jean

Published
2023
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21. A circulating subset of BRAF V600E ‐positive cells in infants with high‐risk Langerhans cell histiocytosis treated with BRAF inhibitors

Author

Poch, Rita, primary, Le Louet, Solenne, additional, Hélias‐Rodzewicz, Zofia, additional, Hachem, Nawa, additional, Plat, Geneviève, additional, Barkaoui, Mohamed‐Aziz, additional, Lapillonne, Hélène, additional, Delhommeau, François, additional, Emile, Jean‐François, additional, Donadieu, Jean, additional, and Héritier, Sébastien, additional

Published
2021
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23. The use of plants in the traditional treatment of diabetes patients: survey in southern Morocco.

Author

BOULLANI, Rachida EL, BARKAOUI, Mohamed, LAGRAM, Khalid, FINTI, Aissam EL, KAMEL, Nadia, MOUSADIK, Abdelhamid EL, SERGHINI, Mohammed A., and MSANDA, Fouad

Subjects
*PEOPLE with diabetes, *SEMI-structured interviews, *PATIENT surveys, *FENUGREEK, *MEDICINAL plants, *PLANT species, *TRADITIONAL medicine
Abstract

This study was conducted in public healthcare establishments in Guelmim city in south of Morocco to report medicinal plants used in folk medicine to treat diabetes. Three hundred sixty-two informants were interviewed through semi structured interviews. The inventory includes scienti

Published
2022
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24. Thymus and mediastinal node involvement in childhood langerhans cell histiocytosis: Long-term follow-up from the French national cohort

Author

Ducassou, Stephane, Seyrig, Fanny, Thomas, Caroline, Lambilliotte, Anne, Marec-Berard, Perrine, Berger, Claire, Plat, Genevieve, Brugiere, Laurence, Ouache, Marie, Barkaoui, Mohamed, Armari-Alla, Corinne, Lutz, Patrick, Leverger, Guy, Rialland, Xavier, Mansuy, Ludovic, Pacquement, Helene, Jeziorski, Eric, Gandemer, Virginie, Chalard, François, Chateil, Jean François, Tazi, Abdellatif, Emile, Jean François, and Donadieu, Jean

Published
2013
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26. Chest computed tomography findings for a cohort of children with pulmonary Langerhans cell histiocytosis

Author

Della Valle, Valeria, primary, Donadieu, Jean, additional, Sileo, Chiara, additional, Barkaoui, Mohamed Aziz, additional, Héritier, Sébastien, additional, Brisse, Hervé, additional, Boutry, Nathalie, additional, Tréguier, Catherine, additional, Chateil, Jean‐François, additional, Petit, Philippe, additional, Pracros, Jean‐Pierre, additional, Chastagner, Pascal, additional, Boyer, Corinne, additional, Veillon, Francis, additional, Durand, Chantal, additional, Mounayer, Charbel, additional, Kambouchner, Marianne, additional, Brauner, Michel, additional, Tazi, Abdellatif, additional, Epaud, Ralp, additional, and Ducou le Pointe, Hubert, additional

Published
2020
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27. Long‐term follow‐up of children with risk organ‐negative Langerhans cell histiocytosis after 2‐chlorodeoxyadenosine treatment

Author

Barkaoui, Mohamed‐Aziz, primary, Queheille, Emma, additional, Aladjidi, Nathalie, additional, Plat, Geneviève, additional, Jeziorski, Eric, additional, Moshous, Despina, additional, Lambilliotte, Anne, additional, Kebaili, Kamila, additional, Pacquement, Hélène, additional, Leverger, Guy, additional, Mansuy, Ludovic, additional, Entz‐Werlé, Natacha, additional, Bodet, Damien, additional, Schneider, Pascale, additional, Pagnier, Anne, additional, Lutun, Anne, additional, Gillibert‐Yvert, Marion, additional, Millot, Fréderic, additional, Toutain, Fabienne, additional, Reguerre, Yves, additional, Thomas, Caroline, additional, Tazi, Abdelatif, additional, Emile, Jean‐François, additional, Donadieu, Jean, additional, and Héritier, Sébastien, additional

Published
2020
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30. Distance learning of physical and sports education in the days of the Corona Virus: Case of Morocco

Author

Koutaya, Ayoub, Eloirdi, Aziz, Barkaoui, Mohamed, Marfouq, Assia, Koutaya, Younes, Eloirdi, Hamid, Koutaya, Ayoub, Eloirdi, Aziz, Barkaoui, Mohamed, Marfouq, Assia, Koutaya, Younes, and Eloirdi, Hamid

Abstract

Distance training or distance learning has experienced a boom in recent years in several regions of the world. It follows from this interest that the emergence of distance learning has been remarkably advocated by higher education institutions and less and less at the secondary and college levels where face-to-face training is becoming essential. However, during the period of health crisis due to Covid-19, distance education had established itself as a new alternative mode for face-to-face education for all levels of education, and for all subjects combined. Physical and sports education (PSE) is no exception to this change. In this context, the discipline EPS has sparked a debate on the modalities of engagement of teachers of EPS to participate in distance education given the almost practical nature of the subject. Faced with this problem, EPS teachers (high school and college) found themselves forced to formalize educational content and transmit it on various media. This study contributes to the identification of the degree of commitment of PE teachers to ensure the sustainability of learning and to determine the obstacles encountered in this operation qualified as urgent. This study saw the participation of 166 teachers in two levels of secondary and college education through three regional academies in Morocco. The results showed both the lack of communication between the inspectors of the EPS and the teachers of the subject, and the coordination between the teachers within the teaching units.     &nbsp, La formation à distance ou l’apprentissage à distance connait son plein essor ces dernières années dans plusieurs régions du monde. Il résulte de cet intérêt que l’émersion de l’apprentissage à distance a été remarquablement prôné par les établissements d’enseignement supérieur et de moins en moins au niveau secondaire et collégial où la formation en présentiel devient essentielle. Cependant, pendant la période de crise sanitaire à cause du Covid-19, l’enseignement à distance s’était imposé comme un nouveau mode alternatif pour le présentiel pour tous les niveaux d’enseignement, et pour toutes les matières confondues. L’éducation physique et sportive (EPS) n’échappe pas à ce changement. Dans ce contexte, la discipline EPS a suscité un débat sur les modalités d’engagement des professeurs d’EPS pour participer à l’enseignement à distance vu la nature quasiment pratique de la matière. Devant ce problème, les enseignants d’EPS (lycée et collège) se sont trouvés contraint de formaliser des contenus pédagogiques et de les transmettre sur différents supports médiatiques. Cette étude contribue à l’identification du degré d’engagement des enseignants d’EPS pour assurer la durabilité des apprentissages et de déterminer les entraves rencontrées dans cette opération qualifiée d’urgente. Cette étude a vu la participation de 166 enseignants dans deux niveaux d’enseignements secondaire et collégial à travers trois académies régionales au Maroc. Les résultats ont montré à la fois l’absence de la communication entre les inspecteurs de l’EPS et les professeurs de la matière, et la coordination entre les professeurs au sein des unités pédagogiques.     &nbsp

Published
2020

35. A circulating subset of BRAFV600E‐positive cells in infants with high‐risk Langerhans cell histiocytosis treated with BRAF inhibitors.

Author

Poch, Rita, Le Louet, Solenne, Hélias‐Rodzewicz, Zofia, Hachem, Nawa, Plat, Geneviève, Barkaoui, Mohamed‐Aziz, Lapillonne, Hélène, Delhommeau, François, Emile, Jean‐François, Donadieu, Jean, and Héritier, Sébastien

Subjects
LANGERHANS-cell histiocytosis, BRAF genes, THERAPEUTICS, B cells, T cells
Abstract

Summary: BRAF inhibitors are an effective treatment for BRAFV600E‐mutated, risk‐organ‐positive Langerhans cell histiocytosis (RO+ LCH). However, cell‐free BRAFV600E DNA often persists during therapy and recurrence frequently occurs after therapy discontinuation. To identify a pathological reservoir of BRAFV600E‐mutated cells, we studied peripheral blood cells obtained from six infants with RO+ multisystem (MS) LCH that received targeted therapy. After cell sorting, the BRAFV600E mutation was detected in monocytes (n = 5), B lymphocytes (n = 3), T lymphocytes (n = 2), and myeloid and plasmacytoid dendritic cells (n = 2 each). This biomarker may offer an interesting tool for monitoring the effectiveness of new therapeutic approaches for weaning children with RO+ LCH from targeted therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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36. VEMURAFENIB IN CHILDREN WITH REFRACTORY LCH: 53 PATIENTS TREATED IN EU AND LEBANON

Author

Donadieu, Jean, Larabi, Islam Amine, Tardieu, Mathilde, Visser, Johannes, Hutter, Caroline, Sieni, Elena, Kabbara, Nabil, Barkaoui, Mohamed, Milne, Paul, Haroche, Julien, Taly, Valérie, Collinson, Matthew, Alvarez, Jean-Claude, J.F., Emile, Heritier, Sébastien, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie (BECCOH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay, Service de Dermatologie [CHU de Grenoble site Nord], CHU de Grenoble site Nord, Department of Paediatric Oncology and Haematology [Cambridge, UK], University of Cambridge [UK] (CAM), St Anna Kinderspital [Vienna Austria], Dipartimento di Oncoematologia Pediatrica [Firenze, Italy], Azienda Ospedaliero Universitaria A. Meyer [Firenze, Italy], Division Pediatric Hematology Oncology [Beirut, Lebanon], Université Saint-Joseph de Beyrouth (USJ), Pediatric Hematology Oncology [Beirut, Lebanon], Rafic Hariri University Hospital [Beirut, Lebanon], Institute of Cellular Medicine [Newcastle], Newcastle University [Newcastle], Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Saint Anna Children's Hospital [Vienne] = St Anna Kinderspital (St. Anna Children's Hospital), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), and TALY, Valerie

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019
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38. Vemurafenib for Refractory Multisystem Langerhans Cell Histiocytosis in Children: An International Observational Study

Author

Donadieu, Jean, primary, Larabi, Islam Amine, additional, Tardieu, Mathilde, additional, Visser, Johannes, additional, Hutter, Caroline, additional, Sieni, Elena, additional, Kabbara, Nabil, additional, Barkaoui, Mohamed, additional, Miron, Jean, additional, Chalard, François, additional, Milne, Paul, additional, Haroche, Julien, additional, Cohen, Fleur, additional, Hélias-Rodzewicz, Zofia, additional, Simon, Nicolas, additional, Jehanne, Mathilde, additional, Kolenova, Alexandra, additional, Pagnier, Anne, additional, Aladjidi, Nathalie, additional, Schneider, Pascale, additional, Plat, Geneviève, additional, Lutun, Anne, additional, Sonntagbauer, Anne, additional, Lehrnbecher, Thomas, additional, Ferster, Alina, additional, Efremova, Viktoria, additional, Ahlmann, Martina, additional, Blanc, Laurence, additional, Nicholson, James, additional, Lambilliote, Anne, additional, Boudiaf, Houda, additional, Lissat, Andrej, additional, Svojgr, Karel, additional, Bernard, Fanette, additional, Elitzur, Sarah, additional, Golan, Michal, additional, Evseev, Dmitriy, additional, Maschan, Michael, additional, Idbaih, Ahmed, additional, Slater, Olga, additional, Minkov, Milen, additional, Taly, Valerie, additional, Collin, Matthew, additional, Alvarez, Jean-Claude, additional, Emile, Jean-François, additional, and Héritier, Sébastien, additional

Published
2019
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39. Efficacy of vinblastine in central nervous system Langerhans cell histiocytosis: a nationwide retrospective study

Author

Ng Wing Tin Sophie, Martin-Duverneuil Nadine, Idbaih Ahmed, Garel Catherine, Ribeiro Maria, Parker Judith, Defachelles Anne-Sophie, Lambilliotte Anne, Barkaoui Mohamed, Munzer Martine, Gardembas Martine, Sibilia Jean, Lutz Patrick, Fior Renato, Polak Michel, Robert Alain, Aumaitre Olivier, Plantaz Dominique, Armari-Alla Corinne, Genereau Thierry, Berard Perrine, Talom Ghislain, Pennaforte Jean-Loup, Le Pointe Hubert, Barthez Marie-Anne, Couillault Gérard, Haroche Julien, Mokhtari Karima, Donadieu Jean, and Hoang-Xuan Khê

Subjects
Medicine
Abstract

Abstract Background Vinblastine (VBL) is the standard treatment for systemic Langerhans cell histiocytosis (LCH), but little is known about its efficacy in central nervous system (CNS) mass lesions. Methods A retrospective chart review was conducted. Twenty patients from the French LCH Study Group register met the inclusion criteria. In brief, they had CNS mass lesions, had been treated with VBL, and were evaluable for radiologic response. Results The median age at diagnosis of LCH was 11.5 years (range: 1-50). Intravenous VBL 6 mg/m2 was given in a 6-week induction treatment, followed by a maintenance treatment. The median total duration was 12 months (range: 3-30). Eleven patients received steroids concomitantly. Fifteen patients achieved an objective response; five had a complete response (CR: 25%), ten had a partial response (PR: 50%), four had stable disease (SD: 20%) and one patient progressed (PD: 5%). Of interest, four out of the six patients who received VBL without concomitant steroids achieved an objective response. With a median follow-up of 6.8 years, the 5-year event-free and overall survival was 61% and 84%, respectively. VBL was well-tolerated and there were no patient withdrawals due to adverse events. Conclusion VBL, with or without steroids, could potentially be a useful therapeutic option in LCH with CNS mass lesions, especially for those with inoperable lesions or multiple lesions. Prospective clinical trials are warranted for the evaluation of VBL in this indication.

Published
2011
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40. Near-optimal search-and-rescue path planning for a moving target.

Author

Berger, Jean, Barkaoui, Mohamed, and Lo, Nassirou

Subjects
HEURISTIC, LINEAR programming, PROBLEM solving, RESCUE work, SEARCH engines
Abstract

Discrete search and rescue path planning for a moving target problem is computationally hard. Despite heuristic methods proposed so far, for which efficiency is further plagued by random episodic target kinematic behavior, qualifying real solution goodness and specifying optimality gap still remain elusive. In this paper a new alternate formulation is proposed to solve the search path planning problem for a moving target. Rather than tackling explicitly the original problem model, a remarkable property is exploited to solve a conjugate mixed-integer linear programming problem. The approach lies on a compact open-loop search path planning problem model with anticipated feedback to efficiently minimize probability of detection failure as opposed to traditionally maximize cumulative probability of success. Preserving path solution optimality, solving the conjugate problem proves very valuable in significantly reducing computational complexity. This is mainly achievable by virtue of the resulting problem objective property which concisely defines the function to be minimized in terms of terminal belief contributions only. For the first time optimal or upper bound solution computation are made possible in reasonable time for practical size problems. A network representation is further utilized to simplify modeling and facilitate constraint specification. Computational results show the strength of the approach for one and two searching agent problem instances. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Incidence and risk factors for clinical neurodegenerative Langerhans cell histiocytosis: a longitudinal cohort study

Author

Héritier, Sébastien, primary, Barkaoui, Mohamed-Aziz, additional, Miron, Jean, additional, Thomas, Caroline, additional, Moshous, Despina, additional, Lambilliotte, Anne, additional, Mazingue, Françoise, additional, Kebaili, Kamila, additional, Jeziorski, Eric, additional, Plat, Geneviève, additional, Aladjidi, Nathalie, additional, Pacquement, Hélène, additional, Galambrun, Claire, additional, Brugières, Laurence, additional, Leverger, Guy, additional, Mansuy, Ludovic, additional, Paillard, Catherine, additional, Deville, Anne, additional, Pagnier, Anne, additional, Lutun, Anne, additional, Gillibert-Yvert, Marion, additional, Stephan, Jean-Louis, additional, Cohen-Aubart, Fleur, additional, Haroche, Julien, additional, Pellier, Isabelle, additional, Millot, Fréderic, additional, Gandemer, Virginie, additional, Martin-Duverneuil, Nadine, additional, Taly, Valérie, additional, Hélias-Rodzewicz, Zofia, additional, Emile, Jean-François, additional, Hoang-Xuan, Khe, additional, Idbaih, Ahmed, additional, and Donadieu, Jean, additional

Published
2018
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42. Circulating cell-free BRAF V600E as a biomarker in children with Langerhans cell histiocytosis

Author

Héritier, Sébastien, primary, Hélias-Rodzewicz, Zofia, additional, Lapillonne, Hélène, additional, Terrones, Nathalie, additional, Garrigou, Sonia, additional, Normand, Corinne, additional, Barkaoui, Mohamed-Aziz, additional, Miron, Jean, additional, Plat, Geneviève, additional, Aladjidi, Nathalie, additional, Pagnier, Anne, additional, Deville, Anne, additional, Gillibert-Yvert, Marion, additional, Moshous, Despina, additional, Lefèvre-Utile, Alain, additional, Lutun, Anne, additional, Paillard, Catherine, additional, Thomas, Caroline, additional, Jeziorski, Eric, additional, Nizard, Philippe, additional, Taly, Valérie, additional, Emile, Jean-François, additional, and Donadieu, Jean, additional

Published
2017
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44. BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy.

Author

Héritier, Sébastien, Emile, Jean-François, Barkaoui, Mohamed-Aziz, Thomas, Caroline, Fraitag, Sylvie, Boudjemaa, Sabah, Renaud, Florence, Moreau, Anne, Peuchmaur, Michel, Chassagne-Clement, Catherine, Dijoud, Frédérique, Rigau, Valérie, Moshous, Despina, Lambilliotte, Anne, Mazingue, Françoise, Kebaili, Kamila, Miron, Jean, Jeziorski, Eric, Plat, Geneviève, Aladjidi, Nathalie, Ferster, Alina, Pacquement, Hélène, Galambrun, Claire, Brugières, Laurence, Leverger, Guy, Mansuy, Ludovic, Paillard, Catherine, Deville, Anne, Armari-Alla, Corinne, Lutun, Anne, Gillibert-Yvert, Marion, Stephan, Jean Louis, Cohen-Aubart, Fleur, Haroche, Julien, Pellier, Isabelle, Millot, Frédéric, Lescoeur, Brigitte, Gandemer, Virginie, Bodemer, Christine, Lacave, Roger, Hélias-Rodzewicz, Zofia, Taly, Valérie, Geissmann, Frédéric, Donadieu, Jean, Héritier, Sébastien, Emile, Jean-François, Barkaoui, Mohamed-Aziz, Thomas, Caroline, Fraitag, Sylvie, Boudjemaa, Sabah, Renaud, Florence, Moreau, Anne, Peuchmaur, Michel, Chassagne-Clement, Catherine, Dijoud, Frédérique, Rigau, Valérie, Moshous, Despina, Lambilliotte, Anne, Mazingue, Françoise, Kebaili, Kamila, Miron, Jean, Jeziorski, Eric, Plat, Geneviève, Aladjidi, Nathalie, Ferster, Alina, Pacquement, Hélène, Galambrun, Claire, Brugières, Laurence, Leverger, Guy, Mansuy, Ludovic, Paillard, Catherine, Deville, Anne, Armari-Alla, Corinne, Lutun, Anne, Gillibert-Yvert, Marion, Stephan, Jean Louis, Cohen-Aubart, Fleur, Haroche, Julien, Pellier, Isabelle, Millot, Frédéric, Lescoeur, Brigitte, Gandemer, Virginie, Bodemer, Christine, Lacave, Roger, Hélias-Rodzewicz, Zofia, Taly, Valérie, Geissmann, Frédéric, and Donadieu, Jean

Abstract

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with a broad spectrum of clinical manifestations and outcomes in children. The somatic BRAF(V600E) mutation occurs frequently, but clinical significance remains to be determined., info:eu-repo/semantics/published

Published
2016

45. BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy

Author

Héritier, Sébastien, primary, Emile, Jean-François, additional, Barkaoui, Mohamed-Aziz, additional, Thomas, Caroline, additional, Fraitag, Sylvie, additional, Boudjemaa, Sabah, additional, Renaud, Florence, additional, Moreau, Anne, additional, Peuchmaur, Michel, additional, Chassagne-Clément, Catherine, additional, Dijoud, Frédérique, additional, Rigau, Valérie, additional, Moshous, Despina, additional, Lambilliotte, Anne, additional, Mazingue, Françoise, additional, Kebaili, Kamila, additional, Miron, Jean, additional, Jeziorski, Eric, additional, Plat, Geneviève, additional, Aladjidi, Nathalie, additional, Ferster, Alina, additional, Pacquement, Hélène, additional, Galambrun, Claire, additional, Brugières, Laurence, additional, Leverger, Guy, additional, Mansuy, Ludovic, additional, Paillard, Catherine, additional, Deville, Anne, additional, Armari-Alla, Corinne, additional, Lutun, Anne, additional, Gillibert-Yvert, Marion, additional, Stephan, Jean-Louis, additional, Cohen-Aubart, Fleur, additional, Haroche, Julien, additional, Pellier, Isabelle, additional, Millot, Frédéric, additional, Lescoeur, Brigitte, additional, Gandemer, Virginie, additional, Bodemer, Christine, additional, Lacave, Roger, additional, Hélias-Rodzewicz, Zofia, additional, Taly, Valérie, additional, Geissmann, Frédéric, additional, and Donadieu, Jean, additional

Published
2016
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46. Langerhans cell histiocytosis: therapeutic strategy and outcome in a 30‐year nationwide cohort of 1478 patients under 18 years of age

Author

Rigaud, Charlotte, primary, Barkaoui, Mohamed A., additional, Thomas, Caroline, additional, Bertrand, Yves, additional, Lambilliotte, Anne, additional, Miron, Jean, additional, Aladjidi, Nathalie, additional, Plat, Geneviève, additional, Jeziorski, Eric, additional, Galambrun, Claire, additional, Mansuy, Ludovic, additional, Lutz, Patrick, additional, Deville, Anne, additional, Armari‐Alla, Corinne, additional, Reguerre, Yves, additional, Fraitag, Sylvie, additional, Coulomb, Aurore, additional, Gandemer, Virginie, additional, Leboulanger, Nicolas, additional, Moshous, Despina, additional, Hoang‐Xuan, Khe, additional, Tazi, Abdellatif, additional, Heritier, Sébastien, additional, Emile, Jean‐François, additional, and Donadieu, Jean, additional

Published
2016
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47. Langerhans cell histiocytosis in children: Correlation of BRAF status with clinical characteristic.

Author

Héritier, Sébastien, primary, Emile, Jean-François, additional, Barkaoui, Mohamed, additional, Moreau, Anne, additional, Rigau, Valerie, additional, Dijoud, Frédérique, additional, Chassagne, Catherine, additional, Charlotte, Frédéric, additional, Mokhtari, Karima, additional, Boudjemaa, Sabah, additional, Coulomb, Aurore, additional, Peuchmaur, Michel, additional, Copin, Marie-Christine, additional, Fraitag, Sylvie, additional, Molina, Thierry, additional, Jeziorski, Eric, additional, Thomas, Caroline, additional, de Menthon, Mathilde, additional, Haroche, Julien, additional, and Donadieu, Jean, additional

Published
2015
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48. Circulating cell-free BRAFV600E as a biomarker in children with Langerhans cell histiocytosis.

Author

Héritier, Sébastien, Hélias ‐ Rodzewicz, Zofia, Lapillonne, Hélène, Terrones, Nathalie, Garrigou, Sonia, Normand, Corinne, Barkaoui, Mohamed ‐ Aziz, Miron, Jean, Plat, Geneviève, Aladjidi, Nathalie, Pagnier, Anne, Deville, Anne, Gillibert ‐ Yvert, Marion, Moshous, Despina, Lefèvre ‐ Utile, Alain, Lutun, Anne, Paillard, Catherine, Thomas, Caroline, Jeziorski, Eric, and Nizard, Philippe

Subjects
LANGERHANS-cell histiocytosis, BIOMARKERS, ALLELES, GENETIC mutation, INTERSTITIAL lung diseases in children, GENETICS
Abstract

The BRAF V600E mutation is reported in half of patients with Langerhans cell histiocytosis ( LCH). This study investigated the detection of the BRAF V600E allele in circulating cell-free (ccf) DNA in a paediatric LCH cohort. Children with BRAFV600E-mutated LCH were investigated to detect ccf BRAF V600E at diagnosis ( n = 48) and during follow-up ( n = 17) using a picolitre-droplet digital PCR assay. At diagnosis, ccf BRAFV600E was positive in 15/15 (100%) patients with risk-organ positive multisystem ( RO+ MS) LCH, 5/12 (42%) of patients with RO− MS LCH and 3/21 (14%) patients with single-system ( SS) LCH ( P < 0·001, Fisher's exact test). The positive BRAFV600E load was higher for RO+ patients (mean, 2·90%; range, 0·04-11·4%) than for RO− patients (mean, 0·16%; range, 0·01-0·39) ( P = 0·003, Mann-Whitney U test). After first-line vinblastine-steroid induction therapy, 7/7 (100%) of the non-responders remained positive for ccf BRAFV600E compared to 2/4 (50%) of the partial-responders and 0/4 of the complete responders ( P = 0·002, Fisher's exact test). Six children treated with vemurafenib showed a clinical response that was associated with a decrease in the ccf BRAFV600E load at day 15. Thus, ccf BRAFV600E is a promising biomarker for monitoring the response to therapy for children with RO+ MS LCH or RO− LCH resistant to first-line chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2017
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