Search

Your search keyword '"Baris, Dalsu"' showing total 612 results
Start Over Author "Baris, Dalsu"
612 results on '"Baris, Dalsu"'

2. Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Author

Koutros, Stella, Kiemeney, Lambertus A., Pal Choudhury, Parichoy, Milne, Roger L., Lopez de Maturana, Evangelina, Ye, Yuanqing, Joseph, Vijai, Florez-Vargas, Oscar, Dyrskjøt, Lars, Figueroa, Jonine, Dutta, Diptavo, Giles, Graham G., Hildebrandt, Michelle A.T., Offit, Kenneth, Kogevinas, Manolis, Weiderpass, Elisabete, McCullough, Marjorie L., Freedman, Neal D., Albanes, Demetrius, Kooperberg, Charles, Cortessis, Victoria K., Karagas, Margaret R., Johnson, Alison, Schwenn, Molly R., Baris, Dalsu, Furberg, Helena, Bajorin, Dean F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Benhamou, Simone, Kraft, Peter, Porru, Stefano, Carta, Angela, Bishop, Timothy, Southey, Melissa C., Matullo, Giuseppe, Fletcher, Tony, Kumar, Rajiv, Taylor, Jack A., Lamy, Philippe, Prip, Frederik, Kalisz, Mark, Weinstein, Stephanie J., Hengstler, Jan G., Selinski, Silvia, Harland, Mark, Teo, Mark, Kiltie, Anne E., Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Lloreta, Josep, Schned, Alan, Lenz, Petra, Riboli, Elio, Brennan, Paul, Tjønneland, Anne, Otto, Thomas, Ovsiannikov, Daniel, Volkert, Frank, Vermeulen, Sita H., Aben, Katja K., Galesloot, Tessel E., Turman, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J., Hohensee, Chancellor, Hunt, Rebecca, Patel, Alpa V., Huang, Wen-Yi, Thorleifsson, Gudmar, Gago-Dominguez, Manuela, Amiano, Pilar, Golka, Klaus, Stern, Mariana C., Yan, Wusheng, Liu, Jia, Li, Shengchao Alfred, Katta, Shilpa, Hutchinson, Amy, Hicks, Belynda, Wheeler, William A., Purdue, Mark P., McGlynn, Katherine A., Kitahara, Cari M., Haiman, Christopher A., Greene, Mark H., Rafnar, Thorunn, Chatterjee, Nilanjan, Chanock, Stephen J., Wu, Xifeng, Real, Francisco X., Silverman, Debra T., Garcia-Closas, Montserrat, Stefansson, Kari, Prokunina-Olsson, Ludmila, Malats, Núria, and Rothman, Nathaniel

Published
2023
Full Text
View/download PDF

4. Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry

Author

Figueroa, Jonine D, Middlebrooks, Candace D, Banday, A Rouf, Ye, Yuanqing, Garcia-Closas, Montserrat, Chatterjee, Nilanjan, Koutros, Stella, Kiemeney, Lambertus A, Rafnar, Thorunn, Bishop, Timothy, Furberg, Helena, Matullo, Giuseppe, Golka, Klaus, Gago-Dominguez, Manuela, Taylor, Jack A, Fletcher, Tony, Siddiq, Afshan, Cortessis, Victoria K, Kooperberg, Charles, Cussenot, Olivier, Benhamou, Simone, Prescott, Jennifer, Porru, Stefano, Dinney, Colin P, Malats, Núria, Baris, Dalsu, Purdue, Mark P, Jacobs, Eric J, Albanes, Demetrius, Wang, Zhaoming, Chung, Charles C, Vermeulen, Sita H, Aben, Katja K, Galesloot, Tessel E, Thorleifsson, Gudmar, Sulem, Patrick, Stefansson, Kari, Kiltie, Anne E, Harland, Mark, Teo, Mark, Offit, Kenneth, Vijai, Joseph, Bajorin, Dean, Kopp, Ryan, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Selinski, Silvia, Hengstler, Jan G, Gerullis, Holger, Ovsiannikov, Daniel, Blaszkewicz, Meinolf, Castelao, Jose Esteban, Calaza, Manuel, Martinez, Maria Elena, Cordeiro, Patricia, Xu, Zongli, Panduri, Vijayalakshmi, Kumar, Rajiv, Gurzau, Eugene, Koppova, Kvetoslava, Bueno-De-Mesquita, H Bas, Ljungberg, Börje, Clavel-Chapelon, Françoise, Weiderpass, Elisabete, Krogh, Vittorio, Dorronsoro, Miren, Travis, Ruth C, Tjønneland, Anne, Brennan, Paul, Chang-Claude, Jenny, Riboli, Elio, Conti, David, Stern, Marianna C, Pike, Malcolm C, Van Den Berg, David, Yuan, Jian-Min, Hohensee, Chancellor, Jeppson, Rebecca P, Cancel-Tassin, Geraldine, Roupret, Morgan, Comperat, Eva, Turman, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J, Kraft, Peter, Lindstrom, Sara, Carta, Angela, Pavanello, Sofia, Arici, Cecilia, Mastrangelo, Giuseppe, Kamat, Ashish M, Zhang, Liren, Gong, Yilei, Pu, Xia, Hutchinson, Amy, Burdett, Laurie, Wheeler, William A, and Karagas, Margaret R

Subjects
Cancer, Prevention, Human Genome, Genetics, Biotechnology, Urologic Diseases, Aetiology, 2.1 Biological and endogenous factors, Biomarkers, Tumor, Case-Control Studies, Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 20, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide, Risk Factors, Urinary Bladder Neoplasms, White People, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P < 1 × 10(-6)), using additional data from existing GWAS datasets and targeted genotyping for studies that did not have GWAS data. In a combined analysis, which included data on up to 15 058 cases and 286 270 controls, two SNPs achieved genome-wide statistical significance: rs6104690 in a gene desert at 20p12.2 (P = 2.19 × 10(-11)) and rs4907479 within the MCF2L gene at 13q34 (P = 3.3 × 10(-10)). Imputation and fine-mapping analyses were performed in these two regions for a subset of 5551 bladder cancer cases and 10 242 controls. Analyses at the 13q34 region suggest a single signal marked by rs4907479. In contrast, we detected two signals in the 20p12.2 region-the first signal is marked by rs6104690, and the second signal is marked by two moderately correlated SNPs (r(2) = 0.53), rs6108803 and the previously reported rs62185668. The second 20p12.2 signal is more strongly associated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stage) bladder cancer (case-case P ≤ 0.02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer.

Published
2016

5. Supplemental Table 1 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, primary, Dean, Michael, primary, Lee, Donghyuk, primary, Hurson, Amber N., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Prokunina-Olsson, Ludmila, primary, Friesen, Melissa C., primary, Zhu, Bin, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, and Koutros, Stella, primary

Published
2023
Full Text
View/download PDF

7. Table S1 from Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection

Author

Rao, Nina, primary, Starrett, Gabriel J., primary, Piaskowski, Mary L., primary, Butler, Kelly E., primary, Golubeva, Yelena, primary, Yan, Wusheng, primary, Lawrence, Scott M., primary, Dean, Michael, primary, Garcia-Closas, Montserrat, primary, Baris, Dalsu, primary, Johnson, Alison, primary, Schwenn, Molly, primary, Malats, Nuria, primary, Real, Francisco X., primary, Kogevinas, Manolis, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, Dyrskjøt, Lars, primary, Buck, Christopher B., primary, Koutros, Stella, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

8. Data from Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection

Author

Rao, Nina, primary, Starrett, Gabriel J., primary, Piaskowski, Mary L., primary, Butler, Kelly E., primary, Golubeva, Yelena, primary, Yan, Wusheng, primary, Lawrence, Scott M., primary, Dean, Michael, primary, Garcia-Closas, Montserrat, primary, Baris, Dalsu, primary, Johnson, Alison, primary, Schwenn, Molly, primary, Malats, Nuria, primary, Real, Francisco X., primary, Kogevinas, Manolis, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, Dyrskjøt, Lars, primary, Buck, Christopher B., primary, Koutros, Stella, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

9. Figure S1 from Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection

Author

Rao, Nina, primary, Starrett, Gabriel J., primary, Piaskowski, Mary L., primary, Butler, Kelly E., primary, Golubeva, Yelena, primary, Yan, Wusheng, primary, Lawrence, Scott M., primary, Dean, Michael, primary, Garcia-Closas, Montserrat, primary, Baris, Dalsu, primary, Johnson, Alison, primary, Schwenn, Molly, primary, Malats, Nuria, primary, Real, Francisco X., primary, Kogevinas, Manolis, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, Dyrskjøt, Lars, primary, Buck, Christopher B., primary, Koutros, Stella, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

12. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Tobacco, Clinical Research, Urologic Diseases, Lung, Genetics, Rare Diseases, Lung Cancer, Human Genome, Hematology, Cancer, Tobacco Smoke and Health, Prevention, Lymphoma, Adult, Aged, Asian People, Bone Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Neoplasms, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Neoplasms, Osteosarcoma, Polymorphism, Single Nucleotide, Smoking, Testicular Neoplasms, Tissue Array Analysis, Urinary Bladder Neoplasms, White People, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

13. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Humans, Neoplasms, Osteosarcoma, Bone Neoplasms, Testicular Neoplasms, Lung Neoplasms, Kidney Neoplasms, Genetic Predisposition to Disease, Tissue Array Analysis, Smoking, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Asian Continental Ancestry Group, European Continental Ancestry Group, Female, Male, Urinary Bladder Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Oncology And Carcinogenesis, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

14. Exposure–response relationships for select cancer and non-cancer health outcomes in a cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950–2009)

Author

Daniels, Robert D, Bertke, Stephen, Dahm, Matthew M, Yiin, James H, Kubale, Travis L, Hales, Thomas R, Baris, Dalsu, Zahm, Shelia H, Beaumont, James J, Waters, Kathleen M, and Pinkerton, Lynne E

Subjects
Prevention, Aging, Lung Cancer, Cancer, Lung, Digestive Diseases, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Good Health and Well Being, Adult, Age Distribution, Aged, Cause of Death, Chicago, Cohort Studies, Firefighters, Humans, Incidence, Leukemia, Lung Neoplasms, Male, Middle Aged, Occupational Diseases, Occupational Exposure, Philadelphia, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Assessment, San Francisco, Survival Analysis, Clinical Sciences, Public Health and Health Services, Other Commerce, Management, Tourism and Services, Environmental & Occupational Health
Abstract

ObjectivesTo examine exposure-response relationships between surrogates of firefighting exposure and select outcomes among previously studied US career firefighters.MethodsEight cancer and four non-cancer outcomes were examined using conditional logistic regression. Incidence density sampling was used to match each case to 200 controls on attained age. Days accrued in firefighting assignments (exposed-days), run totals (fire-runs) and run times (fire-hours) were used as exposure surrogates. HRs comparing 75th and 25th centiles of lagged cumulative exposures were calculated using loglinear, linear, log-quadratic, power and restricted cubic spline general relative risk models. Piecewise constant models were used to examine risk differences by time since exposure, age at exposure and calendar period.ResultsAmong 19,309 male firefighters eligible for the study, there were 1333 cancer deaths and 2609 cancer incidence cases. Significant positive associations between fire-hours and lung cancer mortality and incidence were evident. A similar relation between leukaemia mortality and fire-runs was also found. The lung cancer associations were nearly linear in cumulative exposure, while the association with leukaemia mortality was attenuated at higher exposure levels and greater for recent exposures. Significant negative associations were evident for the exposure surrogates and colorectal and prostate cancers, suggesting a healthy worker survivor effect possibly enhanced by medical screening.ConclusionsLung cancer and leukaemia mortality risks were modestly increasing with firefighter exposures. These findings add to evidence of a causal association between firefighting and cancer. Nevertheless, small effects merit cautious interpretation. We plan to continue to follow the occurrence of disease and injury in this cohort.

Published
2015

15. Pooled study of occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma

Author

De Roos, Anneclaire J, Spinelli, John, Brown, Elizabeth B, Atanackovic, Djordje, Baris, Dalsu, Bernstein, Leslie, Bhatti, Parveen, Camp, Nicola J, Chiu, Brian C, Clavel, Jacqueline, Cozen, Wendy, De Sanjosé, Silvia, Dosman, James A, Hofmann, Jonathan N, McLaughlin, John R, Miligi, Lucia, Monnereau, Alain, Orsi, Laurent, Purdue, Mark P, Schinasi, Leah H, Tricot, Guido J, Wang, Sophia S, Zhang, Yawei, Birmann, Brenda M, and Cocco, Pierluigi

Published
2018

16. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C, Sampson, Joshua N, Hoskins, Jason W, Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S, Abnet, Christian C, Adjei, Andrew A, Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E, Ambrosone, Christine B, Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Arici, Cecilia, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Beane Freeman, Laura E, Berg, Christine D, Berndt, Sonja I, Bertazzi, Pier Alberto, Biritwum, Richard B, Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brennan, Paul, Brinton, Louise A, Brotzman, Michelle, Bueno-de-Mesquita, H Bas, Buring, Julie E, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P, Chu, Lisa W, Clavel-Chapelon, Francoise, Colditz, Graham A, Colt, Joanne S, Conti, David, Cook, Michael B, Cortessis, Victoria K, Crawford, E David, Cussenot, Olivier, Davis, Faith G, De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P, Di Stefano, Anna Luisa, Diver, W Ryan, Duell, Eric J, Elena, Joanne W, Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D, Flanagan, Adrienne M, Fraumeni, Joseph F, Freedman, Neal D, Fridley, Brooke L, Fuchs, Charles S, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, and Garcia-Closas, Montserrat

Subjects
Biological Sciences, Genetics, Cancer, Clinical Research, Human Genome, Prevention, Aetiology, 2.1 Biological and endogenous factors, Alleles, Chromosomes, Human, Pair 5, Computational Biology, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Membrane Proteins, Neoplasm Proteins, Neoplasms, Odds Ratio, Polymorphism, Single Nucleotide, Risk, Telomerase, Medical and Health Sciences, Genetics & Heredity
Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

17. Disinfection By-Products in Drinking Water and Bladder Cancer: Evaluation of Risk Modification by Common Genetic Polymorphisms in Two Case-Control Studies

Author

Freeman, Laura E. Beane, Kogevinas, Manolis, Cantor, Kenneth P., Villanueva, Cristina M., Prokunina-Olsson, Ludmila, Florez-Vargas, Oscar, Figueroa, Jonine D., Ward, Mary H., Koutros, Stella, Baris, Dalsu, Garcia-Closas, Montserrat, Schwenn, Molly, Johnson, Allison, Serra, Consol, Tardon, Adonina, Garcia-Closas, Reina, Carrato, Alfredo, Malats, Nuria, Karagas, Margaret R., Rothman, Nathaniel, and Silverman, Debra T.

Subjects
Toxicogenomics -- Research, Drinking water -- Contamination -- Health aspects, Bladder cancer -- Risk factors -- Environmental aspects -- Genetic aspects, Single nucleotide polymorphisms -- Health aspects, Trihalomethanes -- Environmental aspects -- Health aspects, Environmental issues, Health
Abstract

Background: By-products are formed when disinfectants react with organic matter in source water. The most common class of disinfection byproducts, trihalomethanes (THMs), have been linked to bladder cancer. Several studies have shown exposure-response associations with THMs in drinking water and bladder cancer risk. Few epidemiologic studies have evaluated gene-environment interactions for total THMs (TTHMs) with known bladder cancer susceptibility variants. Objectives: In this study, we investigated the combined effect on bladder cancer risk contributed by TTHMs, bladder cancer susceptibility variants identified through genome-wide association studies, and variants in several candidate genes. Methods: We analyzed data from two large case-control studies--the New England Bladder Cancer Study (n/n = 989 cases/1,162 controls), a population-based study, and the Spanish Bladder Cancer Study (n/n = 706 cases/772 controls), a hospital-based study. Because of differences in exposure distributions and metrics, we estimated effects of THMs and genetic variants within each study separately using adjusted logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (CI) with and without interaction terms, and then combined the results using meta-analysis. Results: Of the 16 loci showing strong evidence of association with bladder cancer, rs907611 at 11p15.5 [leukocyte- specific protein 1 (LSP1 region)] showed the strongest associations in the highest exposure category in each study, with evidence of interaction in both studies and in metaanalysis. In the highest exposure category, we observed OR= 1.66 (95% CI: 1.17, 2.34, p- trend = 0.005) for those with the rs907611-GG genotype and p-interaction = 0.02. No other genetic variants tested showed consistent evidence of interaction. Discussion: We found novel suggestive evidence for a multiplicative interaction between a putative bladder carcinogen, TTHMs, and genotypes of rs907611. Given the ubiquitous exposure to THMs, further work is needed to replicate and extend this finding and to understand potential molecular mechanisms. https://doi.org/10.1289/EHP9895, Introduction Worldwide, bladder cancer ranks as the ninth most common incident cancer and the 13th in mortality, with ~400,000 cases diagnosed each year. (1) Approximately 75% of incident cases occur [...]

Published
2022
Full Text
View/download PDF

18. Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950–2009)

Author

Daniels, Robert D, Kubale, Travis L, Yiin, James H, Dahm, Matthew M, Hales, Thomas R, Baris, Dalsu, Zahm, Shelia H, Beaumont, James J, Waters, Kathleen M, and Pinkerton, Lynne E

Subjects
Epidemiology, Public Health, Health Sciences, Prevention, Cancer, Lung, Good Health and Well Being, Adult, Aged, Asbestos, Cause of Death, Chicago, Cohort Studies, Digestive System Neoplasms, Female, Firefighters, Humans, Incidence, Lung Neoplasms, Male, Mesothelioma, Mesothelioma, Malignant, Middle Aged, Neoplasms, Occupational Diseases, Occupational Exposure, Philadelphia, Respiratory Tract Neoplasms, San Francisco, Longitudinal studies < Methodology, speciality, Clinical Sciences, Public Health and Health Services, Other Commerce, Management, Tourism and Services, Environmental & Occupational Health, Human resources and industrial relations, Public health
Abstract

ObjectivesTo examine mortality patterns and cancer incidence in a pooled cohort of 29 993 US career firefighters employed since 1950 and followed through 2009.MethodsMortality and cancer incidence were evaluated by life table methods with the US population referent. Standardised mortality (SMR) and incidence (SIR) ratios were determined for 92 causes of death and 41 cancer incidence groupings. Analyses focused on 15 outcomes of a priori interest. Sensitivity analyses were conducted to examine the potential for significant bias.ResultsPerson-years at risk totalled 858 938 and 403 152 for mortality and incidence analyses, respectively. All-cause mortality was at expectation (SMR=0.99, 95% CI 0.97 to 1.01, n=12 028). There was excess cancer mortality (SMR=1.14, 95% CI 1.10 to 1.18, n=3285) and incidence (SIR=1.09, 95% CI 1.06 to 1.12, n=4461) comprised mainly of digestive (SMR=1.26, 95% CI 1.18 to 1.34, n=928; SIR=1.17, 95% CI 1.10 to 1.25, n=930) and respiratory (SMR=1.10, 95% CI 1.04 to 1.17, n=1096; SIR=1.16, 95% CI 1.08 to 1.24, n=813) cancers. Consistent with previous reports, modest elevations were observed in several solid cancers; however, evidence of excess lymphatic or haematopoietic cancers was lacking. This study is the first to report excess malignant mesothelioma (SMR=2.00, 95% CI 1.03 to 3.49, n=12; SIR=2.29, 95% CI 1.60 to 3.19, n=35) among US firefighters. Results appeared robust under differing assumptions and analytic techniques.ConclusionsOur results provide evidence of a relation between firefighting and cancer. The new finding of excess malignant mesothelioma is noteworthy, given that asbestos exposure is a known hazard of firefighting.

Published
2014

19. Urinary mutagenicity and bladder cancer risk in northern New England.

Author

Wong, Jason Y. Y., Fischer, Alexander H., Baris, Dalsu, Beane Freeman, Laura E., Karagas, Margaret R., Schwenn, Molly, Johnson, Alison, Matthews, Peggy P., Swank, Adam E., Hosain, G. Monawar, Koutros, Stella, Silverman, Debra T., DeMarini, David M., and Rothman, Nathaniel

Subjects
BLADDER cancer, DISEASE risk factors, BLADDER, SMOKING statistics, AMES test, UROTHELIUM, ETIOLOGY of cancer
Abstract

The etiology of bladder cancer among never smokers without occupational or environmental exposure to established urothelial carcinogens remains unclear. Urinary mutagenicity is an integrative measure that reflects recent exposure to genotoxic agents. Here, we investigated its potential association with bladder cancer in rural northern New England. We analyzed 156 bladder cancer cases and 247 cancer‐free controls from a large population‐based case–control study conducted in Maine, New Hampshire, and Vermont. Overnight urine samples were deconjugated enzymatically and the extracted organics were assessed for mutagenicity using the plate‐incorporation Ames assay with the Salmonella frameshift strain YG1041 + S9. Logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) of bladder cancer in relation to having mutagenic versus nonmutagenic urine, adjusted for age, sex, and state, and stratified by smoking status (never, former, and current). We found evidence for an association between having mutagenic urine and increased bladder cancer risk among never smokers (OR = 3.8, 95% CI: 1.3–11.2) but not among former or current smokers. Risk could not be estimated among current smokers because nearly all cases and controls had mutagenic urine. Urinary mutagenicity among never‐smoking controls could not be explained by recent exposure to established occupational and environmental mutagenic bladder carcinogens evaluated in our study. Our findings suggest that among never smokers, urinary mutagenicity potentially reflects genotoxic exposure profiles relevant to bladder carcinogenesis. Future studies are needed to replicate our findings and identify compounds and their sources that influence bladder cancer risk. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

20. Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection

Author

Rao, Nina, primary, Starrett, Gabriel J., additional, Piaskowski, Mary L., additional, Butler, Kelly E., additional, Golubeva, Yelena, additional, Yan, Wusheng, additional, Lawrence, Scott M., additional, Dean, Michael, additional, Garcia-Closas, Montserrat, additional, Baris, Dalsu, additional, Johnson, Alison, additional, Schwenn, Molly, additional, Malats, Nuria, additional, Real, Francisco X., additional, Kogevinas, Manolis, additional, Rothman, Nathaniel, additional, Silverman, Debra T., additional, Dyrskjøt, Lars, additional, Buck, Christopher B., additional, Koutros, Stella, additional, and Prokunina-Olsson, Ludmila, additional

Published
2023
Full Text
View/download PDF

21. Identification of Genetic Risk Factors for Familial Urinary Bladder Cancer: An Exome Sequencing Study

Author

Pemov, Alexander, Wegman-Ostrosky, Talia, Kim, Jung, Koutros, Stella, Douthitt, Brenna, Jones, Kristine, Zhu, Bin, Baris, Dalsu, Schwenn, Molly, Johnson, Alison, Karagas, Margaret R., Carter, Brian D., McCullough, Marjorie L., Landi, Maria Teresa, Freedman, Neal D., Albanes, Demetrius, Silverman, Debra T., Rothman, Nathaniel, Caporaso, Neil E., Greene, Mark H., Fraumeni, Joseph F., Jr, and Stewart, Douglas R.

Published
2021
Full Text
View/download PDF

23. Urine pH and Risk of Bladder Cancer in Northern New England

Author

Fischer, Alexander H., primary, Wong, Jason Y.Y., additional, Baris, Dalsu, additional, Koutros, Stella, additional, Karagas, Margaret R., additional, Schwenn, Molly, additional, Johnson, Alison, additional, Alguacil, Juan, additional, Silverman, Debra T., additional, and Rothman, Nathaniel, additional

Published
2023
Full Text
View/download PDF

24. Supplemental Table 5 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, primary, Dean, Michael, primary, Lee, Donghyuk, primary, Hurson, Amber N., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Prokunina-Olsson, Ludmila, primary, Friesen, Melissa C., primary, Zhu, Bin, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, and Koutros, Stella, primary

Published
2023
Full Text
View/download PDF

25. Data from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, primary, Dean, Michael, primary, Lee, Donghyuk, primary, Hurson, Amber N., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Prokunina-Olsson, Ludmila, primary, Friesen, Melissa C., primary, Zhu, Bin, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, and Koutros, Stella, primary

Published
2023
Full Text
View/download PDF

26. Supplemental Table 6 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, primary, Dean, Michael, primary, Lee, Donghyuk, primary, Hurson, Amber N., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Prokunina-Olsson, Ludmila, primary, Friesen, Melissa C., primary, Zhu, Bin, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, and Koutros, Stella, primary

Published
2023
Full Text
View/download PDF

27. Supplemental Table 2 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, primary, Dean, Michael, primary, Lee, Donghyuk, primary, Hurson, Amber N., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Prokunina-Olsson, Ludmila, primary, Friesen, Melissa C., primary, Zhu, Bin, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, and Koutros, Stella, primary

Published
2023
Full Text
View/download PDF

28. Supplemental Table 3 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, primary, Dean, Michael, primary, Lee, Donghyuk, primary, Hurson, Amber N., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Prokunina-Olsson, Ludmila, primary, Friesen, Melissa C., primary, Zhu, Bin, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, and Koutros, Stella, primary

Published
2023
Full Text
View/download PDF

29. Supplemental Table 4 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, primary, Dean, Michael, primary, Lee, Donghyuk, primary, Hurson, Amber N., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Prokunina-Olsson, Ludmila, primary, Friesen, Melissa C., primary, Zhu, Bin, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, and Koutros, Stella, primary

Published
2023
Full Text
View/download PDF

30. Supplemental Table 7 from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, primary, Dean, Michael, primary, Lee, Donghyuk, primary, Hurson, Amber N., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Prokunina-Olsson, Ludmila, primary, Friesen, Melissa C., primary, Zhu, Bin, primary, Rothman, Nathaniel, primary, Silverman, Debra T., primary, and Koutros, Stella, primary

Published
2023
Full Text
View/download PDF

31. Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Author

Gonzalez, Nicole, primary, Rao, Nina, additional, Dean, Michael, additional, Lee, Donghyuk, additional, Hurson, Amber N., additional, Baris, Dalsu, additional, Schwenn, Molly, additional, Johnson, Alison, additional, Prokunina-Olsson, Ludmila, additional, Friesen, Melissa C., additional, Zhu, Bin, additional, Rothman, Nathaniel, additional, Silverman, Debra T., additional, and Koutros, Stella, additional

Published
2023
Full Text
View/download PDF

37. Supplementary Table 2 from A Pooled Analysis of Alcohol Consumption and Risk of Multiple Myeloma in the International Multiple Myeloma Consortium

Author

Andreotti, Gabriella, primary, Birmann, Brenda, primary, De Roos, Anneclaire J., primary, Spinelli, John, primary, Cozen, Wendy, primary, Camp, Nicola J., primary, Moysich, Kirsten, primary, Chiu, Brian, primary, Steplowski, Emily, primary, Krzystan, Joseph, primary, Boffetta, Paolo, primary, Benhaim-Luzon, Véronique, primary, Brennan, Paul, primary, de Sanjosé, Silvia, primary, Costas, Laura, primary, Costantini, Adele Seniori, primary, Miligi, Lucia, primary, Cocco, Pierluigi, primary, Becker, Nikolaus, primary, Foretová, Lenka, primary, Maynadié, Marc, primary, Nieters, Alexandra, primary, Staines, Anthony, primary, Tricot, Guido, primary, Milliken, Kevin, primary, Weisenburger, Dennis, primary, Zheng, Tongzhang, primary, Baris, Dalsu, primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

38. Data from A Pooled Analysis of Alcohol Consumption and Risk of Multiple Myeloma in the International Multiple Myeloma Consortium

Author

Andreotti, Gabriella, primary, Birmann, Brenda, primary, De Roos, Anneclaire J., primary, Spinelli, John, primary, Cozen, Wendy, primary, Camp, Nicola J., primary, Moysich, Kirsten, primary, Chiu, Brian, primary, Steplowski, Emily, primary, Krzystan, Joseph, primary, Boffetta, Paolo, primary, Benhaim-Luzon, Véronique, primary, Brennan, Paul, primary, de Sanjosé, Silvia, primary, Costas, Laura, primary, Costantini, Adele Seniori, primary, Miligi, Lucia, primary, Cocco, Pierluigi, primary, Becker, Nikolaus, primary, Foretová, Lenka, primary, Maynadié, Marc, primary, Nieters, Alexandra, primary, Staines, Anthony, primary, Tricot, Guido, primary, Milliken, Kevin, primary, Weisenburger, Dennis, primary, Zheng, Tongzhang, primary, Baris, Dalsu, primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

39. Supplementary from Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors

Author

Koutros, Stella, primary, Rao, Nina, primary, Moore, Lee E., primary, Nickerson, Michael L., primary, Lee, Donghyuk, primary, Zhu, Bin, primary, Pardo, Larissa A., primary, Baris, Dalsu, primary, Schwenn, Molly, primary, Johnson, Alison, primary, Jones, Kristine, primary, Garcia-Closas, Montserrat, primary, Prokunina-Olsson, Ludmila, primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Dean, Michael, primary

Published
2023
Full Text
View/download PDF

40. Supplementary Table 3 from A Pooled Analysis of Alcohol Consumption and Risk of Multiple Myeloma in the International Multiple Myeloma Consortium

Author

Andreotti, Gabriella, primary, Birmann, Brenda, primary, De Roos, Anneclaire J., primary, Spinelli, John, primary, Cozen, Wendy, primary, Camp, Nicola J., primary, Moysich, Kirsten, primary, Chiu, Brian, primary, Steplowski, Emily, primary, Krzystan, Joseph, primary, Boffetta, Paolo, primary, Benhaim-Luzon, Véronique, primary, Brennan, Paul, primary, de Sanjosé, Silvia, primary, Costas, Laura, primary, Costantini, Adele Seniori, primary, Miligi, Lucia, primary, Cocco, Pierluigi, primary, Becker, Nikolaus, primary, Foretová, Lenka, primary, Maynadié, Marc, primary, Nieters, Alexandra, primary, Staines, Anthony, primary, Tricot, Guido, primary, Milliken, Kevin, primary, Weisenburger, Dennis, primary, Zheng, Tongzhang, primary, Baris, Dalsu, primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

41. Supplementary data from Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)

Author

Birmann, Brenda M., primary, Andreotti, Gabriella, primary, De Roos, Anneclaire J., primary, Camp, Nicola J., primary, Chiu, Brian C.H., primary, Spinelli, John J., primary, Becker, Nikolaus, primary, Benhaim-Luzon, Véronique, primary, Bhatti, Parveen, primary, Boffetta, Paolo, primary, Brennan, Paul, primary, Brown, Elizabeth E., primary, Cocco, Pierluigi, primary, Costas, Laura, primary, Cozen, Wendy, primary, de Sanjosé, Silvia, primary, Foretová, Lenka, primary, Giles, Graham G., primary, Maynadié, Marc, primary, Moysich, Kirsten, primary, Nieters, Alexandra, primary, Staines, Anthony, primary, Tricot, Guido, primary, Weisenburger, Dennis, primary, Zhang, Yawei, primary, Baris, Dalsu, primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

42. Supplementary Table 1 from A Pooled Analysis of Alcohol Consumption and Risk of Multiple Myeloma in the International Multiple Myeloma Consortium

Author

Andreotti, Gabriella, primary, Birmann, Brenda, primary, De Roos, Anneclaire J., primary, Spinelli, John, primary, Cozen, Wendy, primary, Camp, Nicola J., primary, Moysich, Kirsten, primary, Chiu, Brian, primary, Steplowski, Emily, primary, Krzystan, Joseph, primary, Boffetta, Paolo, primary, Benhaim-Luzon, Véronique, primary, Brennan, Paul, primary, de Sanjosé, Silvia, primary, Costas, Laura, primary, Costantini, Adele Seniori, primary, Miligi, Lucia, primary, Cocco, Pierluigi, primary, Becker, Nikolaus, primary, Foretová, Lenka, primary, Maynadié, Marc, primary, Nieters, Alexandra, primary, Staines, Anthony, primary, Tricot, Guido, primary, Milliken, Kevin, primary, Weisenburger, Dennis, primary, Zheng, Tongzhang, primary, Baris, Dalsu, primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

43. Supplemental Table 1. from A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium

Author

Costas, Laura, primary, Lambert, Brice H., primary, Birmann, Brenda M., primary, Moysich, Kirsten B., primary, De Roos, Anneclaire J., primary, Hofmann, Jonathan N., primary, Baris, Dalsu, primary, Wang, Sophia S., primary, Camp, Nicola J., primary, Tricot, Guido, primary, Atanackovic, Djordje, primary, Brennan, Paul, primary, Cocco, Pierluigi, primary, Nieters, Alexandra, primary, Becker, Nikolaus, primary, Maynadié, Marc, primary, Foretová, Lenka, primary, Boffetta, Paolo, primary, Staines, Anthony, primary, Brown, Elisabeth E., primary, and de Sanjosé, Silvia, primary

Published
2023
Full Text
View/download PDF

44. Supplemental Figure 1. from A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium

Author

Costas, Laura, primary, Lambert, Brice H., primary, Birmann, Brenda M., primary, Moysich, Kirsten B., primary, De Roos, Anneclaire J., primary, Hofmann, Jonathan N., primary, Baris, Dalsu, primary, Wang, Sophia S., primary, Camp, Nicola J., primary, Tricot, Guido, primary, Atanackovic, Djordje, primary, Brennan, Paul, primary, Cocco, Pierluigi, primary, Nieters, Alexandra, primary, Becker, Nikolaus, primary, Maynadié, Marc, primary, Foretová, Lenka, primary, Boffetta, Paolo, primary, Staines, Anthony, primary, Brown, Elisabeth E., primary, and de Sanjosé, Silvia, primary

Published
2023
Full Text
View/download PDF

45. Supplementary Figure S1 from Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals

Author

Hofmann, Jonathan N., primary, Birmann, Brenda M., primary, Teras, Lauren R., primary, Pfeiffer, Ruth M., primary, Wang, Ye, primary, Albanes, Demetrius, primary, Baris, Dalsu, primary, Colditz, Graham A., primary, De Roos, Anneclaire J., primary, Giles, Graham G., primary, Hosgood, H. Dean, primary, Lan, Qing, primary, Landgren, Ola, primary, Liao, Linda M., primary, Rothman, Nathaniel, primary, Weinstein, Stephanie J., primary, Pollak, Michael N., primary, Neuhouser, Marian L., primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

46. Supplementary Table S2 from Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals

Author

Hofmann, Jonathan N., primary, Birmann, Brenda M., primary, Teras, Lauren R., primary, Pfeiffer, Ruth M., primary, Wang, Ye, primary, Albanes, Demetrius, primary, Baris, Dalsu, primary, Colditz, Graham A., primary, De Roos, Anneclaire J., primary, Giles, Graham G., primary, Hosgood, H. Dean, primary, Lan, Qing, primary, Landgren, Ola, primary, Liao, Linda M., primary, Rothman, Nathaniel, primary, Weinstein, Stephanie J., primary, Pollak, Michael N., primary, Neuhouser, Marian L., primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

47. Data from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

48. Supplemenatary Methods and References from Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals

Author

Hofmann, Jonathan N., primary, Birmann, Brenda M., primary, Teras, Lauren R., primary, Pfeiffer, Ruth M., primary, Wang, Ye, primary, Albanes, Demetrius, primary, Baris, Dalsu, primary, Colditz, Graham A., primary, De Roos, Anneclaire J., primary, Giles, Graham G., primary, Hosgood, H. Dean, primary, Lan, Qing, primary, Landgren, Ola, primary, Liao, Linda M., primary, Rothman, Nathaniel, primary, Weinstein, Stephanie J., primary, Pollak, Michael N., primary, Neuhouser, Marian L., primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

49. Data from Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals

Author

Hofmann, Jonathan N., primary, Birmann, Brenda M., primary, Teras, Lauren R., primary, Pfeiffer, Ruth M., primary, Wang, Ye, primary, Albanes, Demetrius, primary, Baris, Dalsu, primary, Colditz, Graham A., primary, De Roos, Anneclaire J., primary, Giles, Graham G., primary, Hosgood, H. Dean, primary, Lan, Qing, primary, Landgren, Ola, primary, Liao, Linda M., primary, Rothman, Nathaniel, primary, Weinstein, Stephanie J., primary, Pollak, Michael N., primary, Neuhouser, Marian L., primary, and Purdue, Mark P., primary

Published
2023
Full Text
View/download PDF

50. Supplementary Materials, Figures 1 - 3, Tables 1 - 4, 6 - 8 from The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease

Author

Fu, Yi-Ping, primary, Kohaar, Indu, primary, Moore, Lee E., primary, Lenz, Petra, primary, Figueroa, Jonine D., primary, Tang, Wei, primary, Porter-Gill, Patricia, primary, Chatterjee, Nilanjan, primary, Scott-Johnson, Alexandra, primary, Garcia-Closas, Montserrat, primary, Muchmore, Brian, primary, Baris, Dalsu, primary, Paquin, Ashley, primary, Ylaya, Kris, primary, Schwenn, Molly, primary, Apolo, Andrea B., primary, Karagas, Margaret R., primary, Tarway, McAnthony, primary, Johnson, Alison, primary, Mumy, Adam, primary, Schned, Alan, primary, Guedez, Liliana, primary, Jones, Michael A., primary, Kida, Masatoshi, primary, Hosain, GM Monawar, primary, Malats, Nuria, primary, Kogevinas, Manolis, primary, Tardon, Adonina, primary, Serra, Consol, primary, Carrato, Alfredo, primary, Garcia-Closas, Reina, primary, Lloreta, Josep, primary, Wu, Xifeng, primary, Purdue, Mark, primary, Andriole, Gerald L., primary, Grubb, Robert L., primary, Black, Amanda, primary, Landi, Maria T., primary, Caporaso, Neil E., primary, Vineis, Paolo, primary, Siddiq, Afshan, primary, Bueno-de-Mesquita, H. Bas, primary, Trichopoulos, Dimitrios, primary, Ljungberg, Börje, primary, Severi, Gianluca, primary, Weiderpass, Elisabete, primary, Krogh, Vittorio, primary, Dorronsoro, Miren, primary, Travis, Ruth C., primary, Tjønneland, Anne, primary, Brennan, Paul, primary, Chang-Claude, Jenny, primary, Riboli, Elio, primary, Prescott, Jennifer, primary, Chen, Constance, primary, De Vivo, Immaculata, primary, Govannucci, Edward, primary, Hunter, David, primary, Kraft, Peter, primary, Lindstrom, Sara, primary, Gapstur, Susan M., primary, Jacobs, Eric J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J., primary, Virtamo, Jarmo, primary, Kooperberg, Charles, primary, Hohensee, Chancellor, primary, Rodabough, Rebecca J., primary, Cortessis, Victoria K., primary, Conti, David V., primary, Gago-Dominguez, Manuela, primary, Stern, Mariana C., primary, Pike, Malcolm C., primary, Van Den Berg, David, primary, Yuan, Jian-Min, primary, Haiman, Christopher A., primary, Cussenot, Olivier, primary, Cancel-Tassin, Geraldine, primary, Roupret, Morgan, primary, Comperat, Eva, primary, Porru, Stefano, primary, Carta, Angela, primary, Pavanello, Sofia, primary, Arici, Cecilia, primary, Mastrangelo, Giuseppe, primary, Grossman, H. Barton, primary, Wang, Zhaoming, primary, Deng, Xiang, primary, Chung, Charles C., primary, Hutchinson, Amy, primary, Burdette, Laurie, primary, Wheeler, William, primary, Fraumeni, Joseph, primary, Chanock, Stephen J., primary, Hewitt, Stephen M., primary, Silverman, Debra T., primary, Rothman, Nathaniel, primary, and Prokunina-Olsson, Ludmila, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results