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24 results on '"Barile, Carmen"'

1. Real-World Treatment with Nivolumab or Cabozantinib for Metastatic Renal Cell Carcinoma (mRCC) in the Veneto Region of Italy: Results of AMOUR Study

Author

Maruzzo, Marco, Pierantoni, Francesco, Bortolami, Alberto, Palleschi, Dario, Zivi, Andrea, Nicodemo, Maurizio, Sartori, Donata, De Vivo, Rocco, Zustovich, Fable, Bimbatti, Davide, Pastorelli, Davide, Vultaggio, Giuseppe Dione, Soraru’, Mariella, Ballestrin, Melissa, Modonesi, Caterina, Randisi, Paola, Barile, Carmen, Perri, Gino, Basso, Umberto, and Zagonel, Vittorina

Published
2022
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4. Characteristics and outcomes of patients (pts) with metastatic castration-sensitive prostate cancer (mCSPC) showing a primary resistance (PR) to docetaxel (DOC): Results from a large real-world database.

Author

Caffo, Orazio, ButtIgliero, Consuelo, Ermacora, Paola, Sorarù, Mariella, Di Girolamo, Stefania, Sabbatini, Roberto, Gori, Stefania, Facchini, Gaetano, Cattrini, Carlo, Marchetti, Andrea, Valcamonico, Francesca, Vignani, Francesca, Conteduca, Vincenza, Sartori, Donata, Barile, Carmen, Naglieri, Emanuele, Calvani, Nicola, Cavo, Alessia, Biasini, Claudia, and Bimbatti, Davide

Published
2024
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5. Supplementary Data from Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients

Author

Afzal, Shoaib, primary, Gusella, Milena, primary, Vainer, Ben, primary, Vogel, Ulla B., primary, Andersen, Jon T., primary, Broedbaek, Kasper, primary, Petersen, Morten, primary, Jimenez-Solem, Espen, primary, Bertolaso, Laura, primary, Barile, Carmen, primary, Padrini, Roberto, primary, Pasini, Felice, primary, Jensen, Søren A., primary, and Poulsen, Henrik E., primary

Published
2023
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7. Prognostic Role of Circulating Tumor Cells in Metastatic Renal Cell Carcinoma: A Large, Multicenter, Prospective Trial

Author

Basso, Umberto, primary, Facchinetti, Antonella, additional, Rossi, Elisabetta, additional, Maruzzo, Marco, additional, Conteduca, Vincenza, additional, Aieta, Michele, additional, Massari, Francesco, additional, Fraccon, Anna Paola, additional, Mucciarini, Claudia, additional, Sava, Teodoro, additional, Santoni, Matteo, additional, Pegoraro, Cristina, additional, Durante, Emilia, additional, Nicodemo, Maurizio, additional, Perin, Alessandra, additional, Bearz, Alessandra, additional, Gatti, Carlo, additional, Fiduccia, Pasquale, additional, Diminutto, Alberto, additional, Barile, Carmen, additional, De Giorgi, Ugo, additional, Zamarchi, Rita, additional, and Zagonel, Vittorina, additional

Published
2021
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8. Use of nivolumab (N) and cabozantinib (C) for treatment of the metastatic renal cell carcinoma (mRCC) in the Veneto region: Results of AMOUR study.

Author

Maruzzo, Marco, primary, Bortolami, Alberto, additional, Palleschi, Dario, additional, Zivi, Andrea, additional, Nicodemo, Maurizio, additional, Sartori, Donata, additional, De Vivo, Rocco, additional, Zustovich, Fable, additional, Bimbatti, Davide, additional, Pastorelli, Davide, additional, Vultaggio, Giuseppe Dione, additional, Soraru', Mariella, additional, Ballestrin, Melissa, additional, Zanchetta, Giulia, additional, Modonesi, Caterina, additional, Randisi, Paola, additional, Barile, Carmen, additional, Perri, Gino, additional, Basso, Umberto, additional, and Zagonel, Vittorina, additional

Published
2021
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11. Predicting steady-state endoxifen plasma concentrations in breast cancer patients by CYP2D6 genotyping or phenotyping. Which approach is more reliable?

Author

Gusella, Milena, Pasini, Felice, Corso, Barbara, Bertolaso, Laura, De Rosa, Giovanni, Falci, Cristina, Modena, Yasmina, Barile, Carmen, Da Corte Z., Donatella, Fraccon, AnnaPaola, Toso, Silvia, Cretella, Elisabetta, Brunello, Antonella, Modonesi, Caterina, Segati, Romana, Oliani, Cristina, Minicuci, Nadia, and Padrini, Roberto

Subjects
BREAST cancer, CANCER patients, REGRESSION analysis, DEXTROMETHORPHAN, MONONUCLEOSIS, PATHOLOGICAL laboratories
Abstract

In previous studies, steady-state Z-endoxifen plasma concentrations (ENDOss) correlated with relapse-free survival in women on tamoxifen (TAM) treatment for breast cancer. ENDOss also correlated significantly with CYP2D6 genotype (activity score) and CYP2D6 phenotype (dextromethorphan test). Our aim was to ascertain which method for assessing CYP2D6 activity is more reliable in predicting ENDOss. The study concerned 203 Caucasian women on tamoxifen-adjuvant therapy (20 mg q.d.). Before starting treatment, CYP2D6 was genotyped (and activity scores computed), and the urinary log(dextromethorphan/dextrorphan) ratio [log(DM/DX)] was calculated after 15 mg of oral dextromethorphan. Plasma concentrations of TAM, N-desmethyl-tamoxifen (ND-TAM), Z-4OH-tamoxifen (4OH-TAM) and ENDO were assayed 1, 4, and 8 months after first administering TAM. Multivariable regression analysis was used to identify the clinical and laboratory variables predicting log-transformed ENDOss (log-ENDOss). Genotype-derived CYP2D6 phenotypes (PM, IM, NM, EM) and log(DM/DX) correlated independently with log-ENDOss. Genotype-phenotype concordance was almost complete only for poor metabolizers, whereas it emerged that 34% of intermediate, normal, and ultrarapid metabolizers were classified differently based on log(DM/DX). Multivariable regression analysis selected log(DM/DX) as the best predictor, with patients’ age, weak inhibitor use, and CYP2D6 phenotype decreasingly important: log-ENDOss = 0.162 - log(DM/ DX) × 0.170 + age × 0.0063 - weak inhibitor use × 0.250 + IM × 0.105 + (NM + UM) × 0.210; (R² = 0.51). In conclusion, log(DM/DX) seems superior to genotype-derived CYP2D6 phenotype in predicting ENDOss. [ABSTRACT FROM AUTHOR]

Published
2020
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12. Clinical outcomes of oral metronomic vinorelbine in advanced non-small cell lung cancer: correlations with pharmacokinetics and MDR1 polymorphisms

Author

Gusella, Milena, primary, Pasini, Felice, additional, Caruso, Donatella, additional, Barile, Carmen, additional, Modena, Yasmina, additional, Fraccon, Anna Paola, additional, Bertolaso, Laura, additional, Menon, Daniela, additional, Crepaldi, Giorgio, additional, Bononi, Antonio, additional, Spezzano, Roberto, additional, Telatin, Giorgia Anna, additional, Corona, Giuseppe, additional, and Padrini, Roberto, additional

Published
2018
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13. Intermittent docetaxel chemotherapy as first-line treatment for metastatic castration-resistant prostate cancer patients

Author

Caffo, Orazio, primary, Lo Re, Giovanni, additional, Sava, Teodoro, additional, Buti, Sebastiano, additional, Sacco, Cosimo, additional, Basso, Umberto, additional, Zustovich, Fable, additional, Lodde, Michele, additional, Perin, Alessandra, additional, Facchini, Gaetano, additional, Veccia, Antonello, additional, Maines, Francesca, additional, Barile, Carmen, additional, Fratino, Lucia, additional, Gernone, Angela, additional, De Vivo, Rocco, additional, Pappagallo, Giovanni L, additional, and Galligioni, Enzo, additional

Published
2015
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14. The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer

Author

Afzal, Shoaib, Gusella, Milena, Jensen, Søren Astrup, Vainer, Ben, Vogel, Ulla Birgitte, Andersen, Jon Trærup, Brødbæk, Kasper, Petersen, Morten, Jimenez-Solem, Espen, Adleff, Vilmos, Budai, Barna, Hitre, Erika, Láng, István, Orosz, Eniko, Bertolaso, Laura, Barile, Carmen, Padrini, Roberto, Kralovánszky, Judit, Pasini, Felice, Poulsen, Henrik Enghusen, Afzal, Shoaib, Gusella, Milena, Jensen, Søren Astrup, Vainer, Ben, Vogel, Ulla Birgitte, Andersen, Jon Trærup, Brødbæk, Kasper, Petersen, Morten, Jimenez-Solem, Espen, Adleff, Vilmos, Budai, Barna, Hitre, Erika, Láng, István, Orosz, Eniko, Bertolaso, Laura, Barile, Carmen, Padrini, Roberto, Kralovánszky, Judit, Pasini, Felice, and Poulsen, Henrik Enghusen

Abstract

The purpose of this study was to investigate whether specific combinations of polymorphisms in 5-fluorouracil (5-FU) metabolism-related genes were associated with outcome in 5-FU-based adjuvant treatment of colorectal cancer.

Published
2011

15. Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients

Author

Afzal, Shoaib, Gusella, Milena, Vainer, Ben, Vogel, Ulla, Andersen, Jon T, Broedbaek, Kasper, Petersen, Morten, Jimenez-Solem, Espen, Bertolaso, Laura, Barile, Carmen, Padrini, Roberto, Pasini, Felice, Jensen, Søren, Poulsen, Henrik E, Afzal, Shoaib, Gusella, Milena, Vainer, Ben, Vogel, Ulla, Andersen, Jon T, Broedbaek, Kasper, Petersen, Morten, Jimenez-Solem, Espen, Bertolaso, Laura, Barile, Carmen, Padrini, Roberto, Pasini, Felice, Jensen, Søren, and Poulsen, Henrik E

Abstract

PURPOSE: The purpose of this study was to investigate whether specific combinations of polymorphisms in genes encoding proteins involved in 5-fluorouracil (5-FU) pharmacokinetics and pharmacodynamics are associated with increased risk of treatment-induced toxicity. EXPERIMENTAL DESIGN: We analyzed two cohorts of 161 and 340 patients, the exploration and validation cohort, respectively. All patients were treated similarly with 5-FU-based adjuvant chemotherapy. We analyzed 13 functional polymorphisms and applied a four-fold analysis strategy using individual polymorphisms, haplotypes, and phenotypic enzyme activity or expression classifications based on combinations of functional polymorphisms in specific genes. Furthermore, multifactor dimensionality reduction analysis was used to identify a genetic interaction profile indicating an increased risk of toxicity. RESULTS: Alleles associated with low activity of methylene tetrahydrofolate reductase (MTHFR) were associated with decreased risk of toxicity [OR(Exploration) 0.39 (95% CI: 0.21-0.71, P = 0.003), OR(Validation) 0.63 (95% CI: 0.41-0.95, P = 0.03)]. A specific combination of the MTHFR 1298A>C and thymidylate synthase (TYMS) 3'-UTR (untranslated region) ins/del polymorphisms was significantly associated with increased toxicity in both cohorts [OR(Exploration) 2.40 (95% CI: 1.33-4.29, P = 0.003), OR(Validation) 1.81 (95% CI: 1.18-2.79, P = 0.007)]. The specific combination was also associated with increased cumulative incidence and earlier occurrence of severe toxicity during treatment. CONCLUSIONS: Our results indicate that MTHFR activity and a specific combination of the MTHFR 1298A>C and TYMS 3'-UTR ins/del polymorphisms are possible predictors of 5-FU treatment-related toxicity. Clin Cancer Res; 17(11); 1-8. ©2011 AACR.

Published
2011

16. Targeted therapies (TT) in metastatic renal cell carcinoma (mRCC): An Italian survey of 902 pts.

Author

Pasini, Felice, primary, Fraccon, Anna Paola, additional, Barile, Carmen, additional, Sacco, Cosimo, additional, Sava, Teodoro, additional, Valduga, Francesco, additional, Basso, Umberto, additional, Vattemi, Emanuela, additional, Rosti, Giovanni, additional, Durante, Emilia, additional, Nicodemo, Maurizio, additional, Lo Re, Giovanni, additional, Cengarle, Rita, additional, Bertocchi, Paola, additional, Bernardi, Daniele, additional, Sartori, Donata, additional, Donati, Donatella, additional, Pegoraro, Cristina, additional, Inno, Alessandro, additional, and Bassan, Franco, additional

Published
2013
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17. The prognostic value of rapid screening tests (RST) in geriatric assessment of patients with cancer over 70.

Author

Bononi, Antonio, primary, Inno, Alessandro, additional, Borghi, Massimo, additional, Tesi, Paolo, additional, Barile, Carmen, additional, Crepaldi, Giorgio, additional, Menon, Daniela, additional, Modena, Yasmina, additional, Fraccon, Anna Paola, additional, Gusella, Milena, additional, Raschella', Guido, additional, and Pasini, Felice, additional

Published
2013
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18. The role of prognostic factors in metastatic renal cell carcinoma (mRCC) treated with targeted therapies (TT): Data from an Italian retrospective multicentric study.

Author

Barile, Carmen, primary, Fraccon, Anna Paola, additional, Zustovich, Fable, additional, Gaion, Fernando, additional, Salvagno, Luigi, additional, Massari, Francesco, additional, Martellucci, Ignazio, additional, Modenesi, Caterina, additional, Giusto, Mauro, additional, Segati, Romana, additional, Bearz, Alessandra, additional, Ogliosi, Chiara, additional, Macrini, Sveva, additional, Maruzzo, Marco, additional, Larussa, Francesca, additional, Nicolardi, Linda, additional, Bonciarelli, Giorgio, additional, Menon, Daniela, additional, Inno, Alessandro, additional, and Pasini, Felice, additional

Published
2013
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19. Factorial phase II randomized trial of continuous (C) or intermittent (I) docetaxel (D) with or without estramustine (E) as first-line treatment for castration-resistant prostate cancer (CRPC): Preliminary results of HOPLITE trial.

Author

Caffo, Orazio, primary, Lo Re, Giovanni, additional, Sava, Teodoro, additional, Buti, Sebastiano, additional, Sacco, Cosimo, additional, Basso, Umberto, additional, Zustovich, Fable, additional, Martini, Thomas, additional, Perin, Alessandra, additional, Veccia, Antonello, additional, Russo, Lucianna, additional, Facchini, Gaetano, additional, Barile, Carmen, additional, Gernone, Angela, additional, Pappagallo, Giovanni L., additional, and Galligioni, Enzo, additional

Published
2012
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20. Preliminary results of a factorial phase II randomized trial of continuous (C) or intermittent (I) docetaxel (DOC) with or without estramustine (E) as first-line treatment for castration-resistant prostate cancer (CRPC) (HOPLITE trial).

Author

Caffo, Orazio, primary, Lo Re, Giovanni, additional, Sava, Teodoro, additional, Buti, Sebastiano, additional, Sacco, Cosimo, additional, Basso, Umberto, additional, Zustovich, Fable, additional, Martini, Thomas, additional, Perin, Alessandra, additional, Veccia, Antonello, additional, Russo, Lucianna, additional, Facchini, Gaetano, additional, Barile, Carmen, additional, Gernone, Angela, additional, De Vivo, Rocco, additional, Pappagallo, Giovanni L., additional, and Galligioni, Enzo, additional

Published
2012
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21. The association of polymorphisms in 5-fluorouracil metabolism genes with outcome in adjuvant treatment of colorectal cancer

Author

Afzal, Shoaib, primary, Gusella, Milena, additional, Jensen, Søren Astrup, additional, Vainer, Ben, additional, Vogel, Ulla, additional, Andersen, Jon Trærup, additional, Brødbæk, Kasper, additional, Petersen, Morten, additional, Jimenez-Solem, Espen, additional, Adleff, Vilmos, additional, Budai, Barna, additional, Hitre, Erika, additional, Láng, István, additional, Orosz, Enikő, additional, Bertolaso, Laura, additional, Barile, Carmen, additional, Padrini, Roberto, additional, Kralovánszky, Judit, additional, Pasini, Felice, additional, and Poulsen, Henrik Enghusen, additional

Published
2011
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22. Combinations of Polymorphisms in Genes Involved in the 5-Fluorouracil Metabolism Pathway Are Associated with Gastrointestinal Toxicity in Chemotherapy-Treated Colorectal Cancer Patients

Author

Afzal, Shoaib, primary, Gusella, Milena, additional, Vainer, Ben, additional, Vogel, Ulla B., additional, Andersen, Jon T., additional, Broedbaek, Kasper, additional, Petersen, Morten, additional, Jimenez-Solem, Espen, additional, Bertolaso, Laura, additional, Barile, Carmen, additional, Padrini, Roberto, additional, Pasini, Felice, additional, Jensen, Søren A., additional, and Poulsen, Henrik E., additional

Published
2011
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23. M30 Neoepitope Expression in Epithelial Cancer: Quantification of Apoptosis in Circulating Tumor Cells by CellSearch Analysis

Author

Rossi, Elisabetta, primary, Basso, Umberto, additional, Celadin, Romina, additional, Zilio, Francesca, additional, Pucciarelli, Salvatore, additional, Aieta, Michele, additional, Barile, Carmen, additional, Sava, Teodoro, additional, Bonciarelli, Giorgio, additional, Tumolo, Salvatore, additional, Ghiotto, Cristina, additional, Magro, Cristina, additional, Jirillo, Antonio, additional, Indraccolo, Stefano, additional, Amadori, Alberto, additional, and Zamarchi, Rita, additional

Published
2010
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24. Daily Low-Dose Subcutaneous Recombinant Interleukin-2 by Alternate Weekly Administration

Author

Tagliaferri, Pierosandro, primary, Barile, Carmen, additional, Caraglia, Michele, additional, Guarrasi, Rosario, additional, Morelli, Daniela, additional, Ricciardi, Beatrice, additional, Martignetti, Angelo, additional, Librera, Maria Teresa, additional, Matano, Elide, additional, Vecchia, Aldo Della, additional, Catalano, Giuseppe, additional, Famiani, Maurizio, additional, Palmieri, Giovannella, additional, Correale, Pierpaolo, additional, and Bianco, Angelo Raffaele, additional

Published
1998
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