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6. GATE : a simulation toolkit for PET and SPECT

Author

Jan, S., Santin, G., Strul, D., Staelens, S., Assie, K., Autret, D., Avner, S., Barbier, R., Bardies, M., Bloomfield, P. M., Brasse, D., Breton, V., Bruyndonckx, P., Buvat, I., Chatziioannou, A. F., Choi, Y., Chung, Y. H., Comtat, C., Donnarieix, D., Ferrer, L., Glick, S. J., Groiselle, C. J., Guez, D., Honore, P. -F., Kerhoas-Cavata, S., Kirov, A. S., Kohli, V., Koole, M., Krieguer, M., van der Laan, D. J., Lamare, F., Largeron, G., Lartizien, C., Lazaro, D., Maas, M. C., Maigne, L., Mayet, F., Melot, F., Merheb, C., Pennacchio, E., Perez, J., Pietrzyk, U., Rannou, F. R., Rey, M., Schaart, D. R., Schmidtlein, C. R., Simon, L., Song, T. Y., Vieira, J. -M., Visvikis, D., Van de Walle, R., Wieers, E., and Morel, C.

Subjects
Physics - Medical Physics, Physics - Biological Physics
Abstract

Monte Carlo simulation is an essential tool in emission tomography that can assist in the design of new medical imaging devices, the optimization of acquisition protocols, and the development or assessment of image reconstruction algorithms and correction techniques. GATE, the Geant4 Application for Tomographic Emission, encapsulates the Geant4 libraries to achieve a modular, versatile, scripted simulation toolkit adapted to the field of nuclear medicine. In particular, GATE allows the description of time-dependent phenomena such as source or detector movement, and source decay kinetics. This feature makes it possible to simulate time curves under realistic acquisition conditions and to test dynamic reconstruction algorithms. A public release of GATE licensed under the GNU Lesser General Public License can be downloaded at the address http://www-lphe.epfl.ch/GATE/.

Published
2004
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11. Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study

Author

Incerti, S., Psaltaki, M., Gillet, P., Barberet, Ph., Bardiès, M., Bernal, M.A., Bordage, M.-C., Breton, V., Davidkova, M., Delage, E., El Bitar, Z., Francis, Z., Guatelli, S., Ivanchenko, A., Ivanchenko, V., Karamitros, M., Lee, S.B., Maigne, L., Meylan, S., Murakami, K., Nieminen, P., Payno, H., Perrot, Y., Petrovic, I., Pham, Q.T., Ristic-Fira, A., Santin, G., Sasaki, T., Seznec, H., Shin, J.I., Stepan, V., Tran, H.N., and Villagrasa, C.

Published
2014
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20. Brief progress report from the intersocietal working group on differentiated thyroid cancer

Author

Verburg, F.A., Ahuja, S., Avram, A.M., Bardies, M., Bernet, V., Bourguet, P., Fuhrer-Sakel, D., Draganescu, C., Daniels, G.H., Greenspan, B., Gulec, S., Hegedus, L., Jonklaas, J., Luster, M., Oyen, W.J., Smit, J.W.A., Tuttle, R.M., Zerdoud, S., Nostrand, D. Van, Verburg, F.A., Ahuja, S., Avram, A.M., Bardies, M., Bernet, V., Bourguet, P., Fuhrer-Sakel, D., Draganescu, C., Daniels, G.H., Greenspan, B., Gulec, S., Hegedus, L., Jonklaas, J., Luster, M., Oyen, W.J., Smit, J.W.A., Tuttle, R.M., Zerdoud, S., and Nostrand, D. Van

Abstract

Contains fulltext : 220726.pdf (Publisher’s version ) (Open Access)

Published
2020

21. From fixed activities to personalized treatments in radionuclide therapy: lost in translation?

Author

Flux, GD, Gleisner, KS, Chiesa, C, Lassmann, M, Chouin, N, Gear, J, Bardies, M, Walrand, S, Bacher, K, Eberlein, U, Ljungberg, M, Strigari, L, Visser, E, Konijnenberg, Mark, Joint Department of Physics [Surrey, UK], Royal Marsden Hospital [Surrey, UK]-Institute of Cancer Research [Surrey, UK], Medical Radiation Physics - Department of Clinical Sciences [Lund, Sweden], Lund University [Lund], Nuclear Medicine [Milan, Italy], Foundation IRCCS Istituto Nazionale Tumori [Milan, Italy], Department of Nuclear Medicine [Würzburg, Germany], Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Oncologie nucléaire (CRCINA - Département NOHMAD - Equipe 13), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Animaux Modèles pour la Recherche en Oncologie [Nantes] (AMaROC), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pôle d’Imagerie Médicale, Radiothérapie et Oncologie (MIRO), Université Catholique de Louvain (UCL), Department of Basic Medical Sciences [Ghent, Belgium], Division of Medical Physics [Ghent, Belgium], Ghent University [Belgium] (UGENT)-Ghent University [Belgium] (UGENT), Laboratory of Medical Physics and Expert Systems [Rome, Italy], National Cancer Institute Regina Elena [Rome, Italy], Department of Radiology and Nuclear Medicine [Nijmegen], Radboud University Medical Center [Nijmegen], Department of Radiology & Nuclear Medicine [Rotterdam, the Netherlands], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Animaux modèles pour la recherche en oncologie comparée (AMaROC), Université Catholique de Louvain = Catholic University of Louvain (UCL), Universiteit Gent = Ghent University [Belgium] (UGENT)-Universiteit Gent = Ghent University [Belgium] (UGENT), Department of Radiology and Nuclear Medicine [Rotterdam, The Netherlands], Animaux Modèles pour la Recherche en Oncologie (AMaROC), Bernardo, Elizabeth, Julius-Maximilians-Universität Würzburg (JMU), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Universiteit Gent = Ghent University (UGENT)-Universiteit Gent = Ghent University (UGENT), Institute of Cancer Research [Surrey, UK]-Royal Marsden Hospital [Surrey, UK], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Angers (UA)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Angers (UA)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire de Nantes (CHU Nantes)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes (UN)-Université d'Angers (UA)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes (UN)-Université d'Angers (UA), UCL - (SLuc) Service de médecine nucléaire, and Radiology & Nuclear Medicine

Subjects
Radioisotopes, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Radiotherapy Dosage, [SDV.CAN]Life Sciences [q-bio]/Cancer, DOSIMETRY, Radioimmunotherapy, Radiation Dosage, CANCER, Embolization, Therapeutic, TOXICITY, [SDV.CAN] Life Sciences [q-bio]/Cancer, HEPATOCELLULAR-CARCINOMA, Neoplasms, Medicine and Health Sciences, Government Regulation, Humans, Registries, Nuclear Medicine, Radiopharmaceuticals, Precision Medicine, DOSE-RESPONSE, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Letter to the Editor, ComputingMilieux_MISCELLANEOUS
Abstract

We read with interest the letter by Giammarile et al. [1] addressing our editorial in which we proposed that the European Medicines Agency should allow the option of a dosimetry-based approach to the treatment of cancer with radionuclide therapy [2]. Our editorial was intended to draw attention to the potential legal issues of recommending an approach to treatment that could contravene the European Council Directive 2013/59 [3] and national legislation, as the directive (article 56) states that “For all medical exposure of patients for radiotherapeutic1 purposes, exposures of target volumes shall be individually planned and their delivery appropriately verified...”. This directive is intended to “lay down basic safety standards for the protection of dangers arising from exposure to ionizing radiation” and emphasizes the need for ‘justification’ and ‘optimization’ of intentional radiation exposures of patients. [...]

Published
2018
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26. From fixed activities to personalized treatments in radionuclide therapy: lost in translation?

Author

Flux, G.D., Gleisner, K. Sjogreen, Chiesa, C., Lassmann, M., Chouin, N., Gear, J., Bardies, M., Walrand, S., Bacher, K., Eberlein, U., Ljungberg, M., Strigari, L., Visser, E.P., Konijnenberg, M.W., Flux, G.D., Gleisner, K. Sjogreen, Chiesa, C., Lassmann, M., Chouin, N., Gear, J., Bardies, M., Walrand, S., Bacher, K., Eberlein, U., Ljungberg, M., Strigari, L., Visser, E.P., and Konijnenberg, M.W.

Abstract

Contains fulltext : 191643.pdf (publisher's version ) (Open Access)

Published
2018

27. Curriculum for education and training of medical physicists in nuclear medicine: recommendations from the EANM Physics Committee, the EANM Dosimetry Committee and EFOMP

Author

Del Guerra, A, Bardies, M, Belcari, Nicola, Caruana, Cj, Christofides, S, Erba, PAOLA ANNA, Gori, C, Lassmann, M, Lonsdale, Mn, Sattler, B, Waddington, W., Del Guerra, A, Bardies, M, Belcari, N, Caruana, C, Christofides, S, Erba, P, Gori, C, Lassmann, M, Lonsdale, M, Sattler, B, and Waddington, W

Subjects
Societies, Scientific, Risk Management, Health Personnel, Physics, Education and training, International Agencies, Medical Physics profession, Physics in Nuclear Medicine, Europe, Equipment and Supplies, Inventions, Humans, Patient Safety, Nuclear Medicine, Radiometry, Occupational Health
Abstract

Purpose: To provide a guideline curriculum covering theoretical and practical aspects of education and training for Medical Physicists in Nuclear Medicine within Europe. Material and methods: National training programmes of Medical Physics, Radiation Physics and Nuclear Medicine physics from a range of European countries and from North America were reviewed and elements of best practice identified. An independent panel of experts was used to achieve consensus regarding the content of the curriculum. Results: Guidelines have been developed for the specialist theoretical knowledge and practical experience required to practice as a Medical Physicist in Nuclear Medicine in Europe. It is assumed that the precondition for the beginning of the training is a good initial degree in Medical Physics at master level (or equivalent). The Learning Outcomes are categorised using the Knowledge, Skill and Competence approach along the lines recommended by the European Qualifications Framework. The minimum level expected in each topic in the theoretical knowledge and practical experience sections is intended to bring trainees up to the requirements expected of a Medical Physicist entering the field of Nuclear Medicine. Conclusions: This new joint EANM/EFOMP European guideline curriculum is a further step to harmonise specialist training of Medical Physicists in Nuclear Medicine within Europe. It provides a common framework for national Medical Physics societies to develop or benchmark their own curricula. The responsibility for the implementation and accreditation of these standards and guidelines resides within national training and regulatory bodies.

Published
2013

28. The conflict between treatment optimization and registration of radiopharmaceuticals with fixed activity posology in oncological nuclear medicine therapy

Author

Chiesa, C., Gleisner, K.S., Flux, G., Gear, J., Walrand, S., Bacher, K., Eberlein, U., Visser, E.P., Chouin, N., Ljungberg, M., Bardies, M., Lassmann, M., Strigari, L., Konijnenberg, M.W., Chiesa, C., Gleisner, K.S., Flux, G., Gear, J., Walrand, S., Bacher, K., Eberlein, U., Visser, E.P., Chouin, N., Ljungberg, M., Bardies, M., Lassmann, M., Strigari, L., and Konijnenberg, M.W.

Abstract

Item does not contain fulltext

Published
2017

31. MIBG Scintigraphy of a Patient with Pheochromocytoma on Labetalol Therapy

Author

A. Chetanneau, Bardies M, Le Marec H, Chatal Jf, M. Kremer, J. Morais, and Peltier P

Subjects
Adult, Male, medicine.medical_specialty, Adrenal Gland Neoplasms, Pheochromocytoma, Scintigraphy, Iodine Radioisotopes, Text mining, Internal medicine, Humans, Medicine, Labetalol, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, medicine.diagnostic_test, Iodobenzenes, business.industry, Imaging study, General Medicine, medicine.disease, 3-Iodobenzylguanidine, Endocrinology, Serial imaging, business, Nuclear medicine, medicine.drug
Abstract

A patient with pheochromocytoma was studied by MIBG scintigraphy while on labetalol therapy, which has been reported to interfere with imaging. Serial imaging was performed at 2, 18, 25, and 90 hours to obtain time/activity curves. Blood samples were taken at each imaging study to determine activity counts. Tumor activity per gram of tissue (surgery 116 hours after injection) was compared with blood activity. Tumor and blood activity decreased concurrently, whereas the decrease in peritumoral activity was faster, thus providing transiently improved contrast on 18- and 25-hour images. The diagnostic implications of these results are discussed.

Published
1992
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36. Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study

Author

Incerti, Sebastien, Psaltaki, M., Gillet, P., Barberet, Ph., Bardies, M., Bernal, Mario A., Bordage, M. -C., Breton, V., Davídková, Marie, Delage, E., El Bitar, Ziad Ei, Francis, Ziad, Guatelli, Susanna, Ivanchenko, A., Ivanchenko, V., Karamitros, Mathieu, Lee, S. B., Maigne, Lydia, Meylan, S., Murakami, Kouichi, Nieminen, P., Payno, H., Perrot, Yann, Petrović, Ivan M., Pham, Q. T., Ristić-Fira, Aleksandra, Santin, G., Sasaki, Takashi, Seznec, H., Shin, J. I., Stepan, Vaclav, Tran, Hoang Ngoc, Villagrasa, Carmen, Geant4-DNA Collaboration, Incerti, Sebastien, Psaltaki, M., Gillet, P., Barberet, Ph., Bardies, M., Bernal, Mario A., Bordage, M. -C., Breton, V., Davídková, Marie, Delage, E., El Bitar, Ziad Ei, Francis, Ziad, Guatelli, Susanna, Ivanchenko, A., Ivanchenko, V., Karamitros, Mathieu, Lee, S. B., Maigne, Lydia, Meylan, S., Murakami, Kouichi, Nieminen, P., Payno, H., Perrot, Yann, Petrović, Ivan M., Pham, Q. T., Ristić-Fira, Aleksandra, Santin, G., Sasaki, Takashi, Seznec, H., Shin, J. I., Stepan, Vaclav, Tran, Hoang Ngoc, Villagrasa, Carmen, and Geant4-DNA Collaboration

Abstract

An accurate modeling of radial energy deposition around ion tracks is a key requirement of radiation transport software used for simulations in radiobiology at the sub-cellular scale. The work presented in this paper is part of the on-going benchmarking of the Geant4-DNA physics processes and models, which are available in the Geant4 Monte Carlo simulation toolkit for the low energy transport of particles in liquid water. We present for the first time radial dose distributions of incident ion tracks simulated with Geant4-DNA. Simulation results are compared to other results available in the literature, obtained from analytical calculations, step-by-step Monte Carlo simulations and measurements. They show a reasonable agreement with reference data. (C) 2014 Elsevier B.V. All rights reserved.

Published
2014

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