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1. Pan-American Guidelines for the treatment of SARS-CoV-2/COVID-19: a joint evidence-based guideline of the Brazilian Society of Infectious Diseases (SBI) and the Pan-American Association of Infectious Diseases (API)

Author

Barbosa, Alexandre Naime, Chebabo, Alberto, Starling, Carlos, Pérez, Clevy, Cunha, Clóvis Arns, de Luna, David, Nunes, Estevão Portela, Zambrano, Gabriela, Ferreira, Juliana Carvalho, Croda, Julio, Falavigna, Maicon, Gomes-da-Silva, Monica Maria, Thormann, Monica, Cimerman, Sergio, Parahiba, Suena Medeiros, Tanni, Suzana, Bernardo, Wanderley Marques, and Rodriguez-Morales, Alfonso J.

Published
2023
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2. Features of Mpox infection: The analysis of the data submitted to the ID-IRI network

Author

Eser-Karlidag, Gulden, Chacon-Cruz, Enrique, Cag, Yasemin, Martinez-Orozco, Jose Arturo, Gudino-Solorio, Humberto, Cruz-Flores, Raul Adrian, Gonzalez-Rodriguez, Andrea, Martinez-Nieves, Daniela, Gomez-Zepeda, Mario, Calderon-Suarez, Andrea, Çaşkurlu, Hülya, Cascio, Antonio, Fernandez, Ricardo, Gonzales, Greisha M., Palma, Pedro, Popescu, Corneliu Petru, Stebel, Roman, Lakatos, Botond, Nagy, Eva, Lanzafame, Massimiliano, El-Kholy, Amani, Tuncer, Buse, Christova, Iva, Krumova, Stefka, Barbosa, Alexandre Naime, Escalera-Antezana, Juan Pablo, Castillo-Quino, Ruben, Gonzales-Flores, Carlos Eduardo, Moreira-Flores, Miriam, Batallanos-Huarachi, Marcelo Felipe, Gomez-Davila, Christian, Baljic, Rusmir, Vieceli, Tarsila, Ariyo, Olumuyiwa Elijah, Llobell, Mireia Cairo, Gideon, Osasona Oluwadamilola, Osborne, Augustus, Elbahr, Umran, Bossi, Philippe, Tammaro, Antonella, Rodriguez-Morales, Alfonso J., and Erdem, Hakan

Published
2023
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3. Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19. A joint guideline of the Brazilian Association of Emergency Medicine (ABRAMEDE), Brazilian Medical Association (AMB), Brazilian Society of Angiology and Vascular Surgery (SBACV), Brazilian Society of Geriatrics and Gerontology (SBGG), Brazilian Society of Infectious Diseases (SBI), Brazilian Society of Family and Community Medicine (SBFMC), and Brazilian Thoracic Society (SBPT)

Author

Falavigna, Maicon, Belli, Karlyse Claudino, Barbosa, Alexandre Naime, Zavascki, Alexandre Prehn, Nastri, Ana Catharina de Seixas Santos, Santana, Christiane Machado, Stein, Cinara, Gräf, Débora Dalmas, Cadegiani, Flavio Adsuara, Guimarães, Hélio Penna, Monteiro, José Tadeu, Ferreira, Juliana Carvalho, de Azevedo, Luciano Cesar Pontes, Magri, Marcelo Mihailenko Chaves, Sobreira, Marcone Lima, Dias, Maria Beatriz Gandra de Souza, de Oliveira, Maura Salaroli, Corradi, Mirian de Freitas Dal Ben, Rosa, Regis, Heinzelmann, Ricardo Souza, da Silva, Rosemeri Maurici, Junior, Rubens Belfort, Cimerman, Sergio, Colpani, Verônica, Veiga, Viviane Cordeiro, and de Carvalho, Carlos Roberto Ribeiro

Published
2022
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6. AVALIAÇÃO DA EFETIVIDADE, IMUNOGENICIDADE E SEGURANÇA DA SEGUNDA DOSE DE REFORÇO (QUARTA DOSE) DA VACINA CONTRA A COVID-19 EM IDOSOS: ESTUDO REFORÇA MAIS (PLUS BOOSTER)

Author

Garcia, Marieli Thomazini Piske, primary, Ferreira, Beatriz Nicoli, additional, Pimentel, Felipe de Castro, additional, Turini, Elaina Aparecida Silva, additional, Filho, Olindo Assis Martins, additional, de Carvalho, Andréa Teixeira, additional, Neto, Lauro Pinto, additional, Maciel, Ethel Leonor Noia, additional, Barbosa, Alexandre Naime, additional, de Medeiros Junior, Nésio Fernandes, additional, Myiamoto, Samira Tatiama, additional, Junior, Luis Carlos Lopes, additional, and Cristo, Valéria Valim, additional

Published
2023
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7. ESTUDO COVID-19 HNH-BR: DETERMINANTES DE RISCO PARA ÓBITO EM PACIENTES HOSPITALIZADOS COM DOENÇA GRAVE/CRÍTICA EM UMA COORTE NACIONAL NO PERÍODO PRÉ-VACINAÇÃO

Author

de Miranda, Thaíni, primary, Vanni, Fernando D Angelo, additional, Vieira, Igor Alberto Andrade, additional, de Souza, Rafaela Caroline, additional, Estella, Pedro Coltro, additional, Sampaio, Raul Pansardis, additional, Santos, Gabriel Manha dos, additional, Oliveira, Laís Ferreira, additional, Gastaldo, Natalia Pascotto, additional, Tasca, Karen Ingrid, additional, and Barbosa, Alexandre Naime, additional

Published
2023
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8. Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19. A joint guideline of the Brazilian Association of Emergency Medicine (ABRAMEDE), Brazilian Medical Association (AMB), Brazilian Society of Angiology and Vascular Surgery (SBACV), Brazilian Society of Geriatrics and Gerontology (SBGG), Brazilian Society of Infectious Diseases (SBI), Brazilian Society of Family and Community Medicine (SBFMC), and Brazilian Thoracic Society (SBPT)

Author

Falavigna, Maicon, Belli, Karlyse Claudino, Barbosa, Alexandre Naime, Zavascki, Alexandre Prehn, de Seixas Santos Nastri, Ana Catharina, Santana, Christiane Machado, Stein, Cinara, Graf, Debora Dalmas, Cadegiani, Flavio Adsuara, Guimaraes, Helio Penna, Monteiro, Jose Tadeu, Ferreira, Juliana Carvalho, de Azevedo, Luciano Cesar Pontes, Magri, Marcelo Mihailenko Chaves, Sobreira, Marcone Lima, de Souza Dias, Maria Beatriz Gandra, de Oliveira, Maura Salaroli, de Freitas Dal Ben Corradi, Mirian, Rosa, Regis, Heinzelmann, Ricardo Souza, da Silva, Rosemeri Maurici, Belfort, Rubens, Jr., Cimerman, Sergio, Colpani, Veronica, Veiga, Viviane Cordeiro, and de Carvalho, Carlos Roberto Ribeiro

Published
2020
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9. Nebulized enriched heparin to treat no critical patients with Sars-Cov-2: Triple-blind clinical trial

Author

Bertanha, Matheus, Rodrigues, Lenize da Silva, Mellucci Filho, Pedro Luciano, Moroz, Andrei, Pardini, Maria Inês de Moura Campos, Sobreira, Marcone Lima, Durigon, Edison Luiz, Machado, Rafael Rahal Guaragna, Grotto, Rejane Maria Tommasini, Lima, Marcelo Andrade de, Nader, Helena Bonciani, Moraes, Marli Leite de, Barbosa, Alexandre Naime, Medolago, Natália Bronzatto, Cardoso, Fábio Florença, Magro, Angelo José, Carvalho, Cristiane Rodrigues Guzzo, Moraes, Leonardo Nazário de, Alvarado, Rita de Cássia, Nunes, Helga Caputo, Campos, Gustavo Constantino de, Grillo, Vinicius Tadeu Ramos da Silva, Sertorio, Nathalia Dias, and Fortaleza, Carlos Magno Castelo Branco

Published
2021
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11. The global challenges of the long COVID-19 in adults and children

Author

Rodriguez-Morales, Alfonso J., primary, Lopez-Echeverri, María Camila, additional, Perez-Raga, Maria Fernanda, additional, Quintero-Romero, Valentina, additional, Valencia-Gallego, Valentina, additional, Galindo-Herrera, Nicolas, additional, López-Alzate, Santiago, additional, Sánchez-Vinasco, Juan Diego, additional, Gutiérrez-Vargas, Juan José, additional, Mayta-Tristan, Percy, additional, Husni, Rola, additional, Moghnieh, Rima, additional, Stephan, Joseph, additional, Faour, Wissam, additional, Tawil, Samah, additional, Barakat, Hanane, additional, Chaaban, Toufic, additional, Megarbane, Andre, additional, Rizk, Youssef, additional, Sakr, Rania, additional, Escalera-Antezana, Juan Pablo, additional, Alvarado-Arnez, Lucia E., additional, Bonilla-Aldana, D. Katterine, additional, Camacho-Moreno, German, additional, Mendoza, Henry, additional, Rodriguez-Sabogal, Ivan Arturo, additional, Millán-Oñate, Jose, additional, Lopardo, Gustavo, additional, Barbosa, Alexandre Naime, additional, Cimerman, Sergio, additional, Chaves, Tânia do Socorro Souza, additional, Orduna, Tomas, additional, Lloveras, Susana, additional, Rodriguez-Morales, Andrea G., additional, Thormann, Monica, additional, Zambrano, Patricia Gabriela, additional, Perez, Clevy, additional, Sandoval, Nancy, additional, Zambrano, Lysien, additional, Alvarez-Moreno, Carlos A., additional, Chacon-Cruz, Enrique, additional, Villamil-Gomez, Wilmer E., additional, Benites-Zapata, Vicente, additional, Savio-Larriera, Eduardo, additional, Cardona-Ospina, Jaime A., additional, Risquez, Alejandro, additional, Forero-Peña, David A., additional, Henao-Martínez, Andrés F., additional, Sah, Ranjit, additional, Barboza, Joshuan J., additional, León-Figueroa, Darwin A., additional, Acosta-España, Jaime David, additional, Carrero-Gonzalez, Carmen María, additional, Al-Tawfiq, Jaffar A., additional, Rabaan, Ali A., additional, Leblebicioglu, Hakan, additional, Gonzales-Zamora, Jose A., additional, and Ulloa-Gutiérrez, Rolando, additional

Published
2023
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13. Pan-American Guidelines for the Treatment of SARS-CoV-2/COVID-19: A Joint Evidence-Based Guideline of the Brazilian Society of Infectious Diseases (SBI) and the Pan-American Association of Infectious Diseases (API)

Author

Barbosa, Alexandre Naime, primary, Chebabo, Alberto, additional, Starling, Carlos, additional, Pérez, Clevy, additional, Cunha, Clóvis Arns, additional, de Luna, David, additional, Nunes, Estevão Portela, additional, Zambrano, Gabriela, additional, Ferreira, Juliana Carvalho, additional, Croda, Júlio, additional, Falavigna, Maicon, additional, Silva, Monica Maria Gomes da, additional, Thormann, Monica, additional, Cimerman, Sergio, additional, Parahiba, Suena Medeiros, additional, Tanni, Suzana, additional, Bernardo, Wanderley Marques, additional, and Rodriguez-Morales, Alfonso J., additional

Published
2023
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14. The II Brazilian Guidelines for the pharmacological treatment of patients hospitalized with COVID-19 Joint Guidelines of the Associação Brasileira de Medicina de Emergência, Associação de Medicina Intensiva Brasileira, Associação Médica Brasileira, Sociedade Brasileira de Angiologia e Cirurgia Vascular, Sociedade Brasileira de Infectologia, Sociedade Brasileira de Pneumologia e Tisiologia and Sociedade Brasileira de Reumatologia

Author

Falavigna, Maicon, primary, Araujo, Cintia Laura Pereira de, additional, Barbosa, Alexandre Naime, additional, Belli, Karlyse Claudino, additional, Colpani, Verônica, additional, Dal-Pizzol, Felipe, additional, Silva, Rosemeri Maurici da, additional, Azevedo, Luciano César Pontes de, additional, Dias, Maria Beatriz Souza, additional, Amaral, José Luiz Gomes do, additional, Dorneles, Gilson Pires, additional, Ferreira, Juliana Carvalho, additional, Freitas, Ana Paula da Rocha, additional, Gräf, Débora Dalmas, additional, Guimarães, Hélio Penna, additional, Lobo, Suzana Margareth Ajeje, additional, Machado, Flávia Ribeiro, additional, Nunes, Michelle Silva, additional, Oliveira, Maura Salaroli de, additional, Parahiba, Suena Medeiros, additional, Rosa, Regis Goulart, additional, Santos, Vania Cristina Canuto, additional, Sobreira, Marcone Lima, additional, Veiga, Viviane Cordeiro, additional, Xavier, Ricardo Machado, additional, Zavascki, Alexandre Prehn, additional, Stein, Cinara, additional, and Carvalho, Carlos Roberto Ribeiro de, additional

Published
2023
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15. II Diretrizes Brasileiras para o tratamento farmacológico de pacientes hospitalizados com COVID-19 Diretriz conjunta da Associação Brasileira de Medicina de Emergência, Associação de Medicina Intensiva Brasileira, Associação Médica Brasileira, Sociedade Brasileira de Angiologia e Cirurgia Vascular, Sociedade Brasileira de Infectologia, Sociedade Brasileira de Pneumologia e Tisiologia e Sociedade Brasileira de Reumatologia

Author

Falavigna, Maicon, primary, Araujo, Cintia Laura Pereira de, additional, Barbosa, Alexandre Naime, additional, Belli, Karlyse Claudino, additional, Colpani, Verônica, additional, Dal-Pizzol, Felipe, additional, Silva, Rosemeri Maurici da, additional, Azevedo, Luciano César Pontes de, additional, Dias, Maria Beatriz Souza, additional, Amaral, José Luiz Gomes do, additional, Dorneles, Gilson Pires, additional, Ferreira, Juliana Carvalho, additional, Freitas, Ana Paula da Rocha, additional, Gräf, Débora Dalmas, additional, Guimarães, Hélio Penna, additional, Lobo, Suzana Margareth Ajeje, additional, Machado, Flávia Ribeiro, additional, Nunes, Michelle Silva, additional, Oliveira, Maura Salaroli de, additional, Parahiba, Suena Medeiros, additional, Rosa, Regis Goulart, additional, Santos, Vania Cristina Canuto, additional, Sobreira, Marcone Lima, additional, Veiga, Viviane Cordeiro, additional, Xavier, Ricardo Machado, additional, Zavascki, Alexandre Prehn, additional, Stein, Cinara, additional, and Carvalho, Carlos Roberto Ribeiro de, additional

Published
2023
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18. Human monkeypox disease (MPX)

Author

Farahat, Ramadan Abdelmoez, Sah, Ranjit, El-Sakka, Amro A., Benmelouka, Amira Yasmine, Kundu, Mrinmoy, Labieb, Fatma, Shaheen, Rahma Sameh, Abdelaal, Abdelaziz, Abdelazeem, Basel, Bonilla-Aldana, D. Katterine, Franco-Paredes, Carlos, Henao-Martinez, Andres F., Garout, Mohammed A., León-Figueroa, Darwin A., Pachar, Monica, Suárez, José Antonio, Ramirez, Juan David, Paniz-Mondolfi, Alberto, Rabaan, Ali A., Al-Tawfiq, Jaffar A., Nishiura, Hiroshi, Ortiz-Martínez, Yeimer, Garcia-Robledo, Juan Esteban, Cimerman, Sergio, Barbosa, Alexandre Naime, Pagliano, Pasquale, Zambrano-Sanchez, Gabriela, Cardona-Ospina, Jaime A., Bížová, Beatrice, and Rodriguez-Morales, Alfonso J.

Subjects
Monkeypox, Orthopoxvirus, global, human, infection, outbreak, Microbiology (medical), Infectious Diseases, Reviews
Abstract

Monkeypox is a rare viral infection, endemic in many central and western African countries. The last international outbreak of monkeypox reported outside Africa occurred back in 2003. However, monkeypox has reemerged at a global scale with numerous confirmed cases across the globe in 2022. The rapid spread of cases through different countries has raised serious concerns among public health officials worldwide prompting accelerated investigations aimed to identify the origins and cause of the rapid expansion of cases. The current situation is reminiscent of the very early stages of the still ongoing COVID-19 pandemic. Overlapping features between these, two seemingly alike viral entities include the possibility for airborne transmission and the currently unexplained and rapid spread across borders. Early recognition of cases and timely intervention of potential transmission chains are necessary to contain further outbreaks. Measures should include rapid and accurate diagnosis of cases meeting case definitions, active surveillance efforts, and appropriate containment of confirmed cases. Governments and health policymakers must apply lessons learned from previous outbreaks and start taking active steps toward limiting the recent global spread of monkeypox. Herein, we discuss the status of the current monkeypox outbreaks worldwide, the epidemio-logical and public health situation at a global scale and what can be done to keep at bay its further expansion and future global implications.

Published
2022

21. Latin America: Situation and preparedness facing the multi-country human monkeypox outbreak

Author

Rodriguez-Morales, Alfonso J., primary, Lopardo, Gustavo, additional, Verbanaz, Sergio, additional, Orduna, Tomas, additional, Lloveras, Susana, additional, Azeñas-Burgoa, Jose María, additional, Escalera-Antezana, Juan Pablo, additional, Alvarado-Arnez, Lucia Elena, additional, Barbosa, Alexandre Naime, additional, Diaz-Quijano, Fredi, additional, Cimerman, Sergio, additional, Chaves, Tânia do Socorro Souza, additional, Rodriguez-Morales, Andrea G., additional, Perret, Cecilia, additional, Méndez, Claudio A., additional, Riera, Jorge A., additional, Bonilla-Aldana, D. Katterine, additional, Camacho-Moreno, German, additional, Mendoza, Henry, additional, Rodriguez-Sabogal, Ivan Arturo, additional, Oñate, Jose, additional, Escobedo, Angel A., additional, Thormann, Monica, additional, Roque, Yori, additional, Zambrano, Patricia Gabriela, additional, Carrero, Yenddy, additional, Sandoval, Nancy, additional, Zambrano, Lysien, additional, Franco-Paredes, Carlos, additional, Chacon-Cruz, Enrique, additional, Lopez-Delgado, Iván, additional, Cuadra-Sánchez, Cesar, additional, Pachar-Flores, Monica, additional, Correa, Ricardo, additional, Rodriguez-Enciso, Hernan D., additional, Rotela-Fisch, Veronica, additional, Maquera-Afaray, Julio, additional, Herrera-Añazco, Percy, additional, Benites-Zapata, Vicente, additional, Savio-Larriera, Eduardo, additional, Ramírez, Juan David, additional, Paniz-Mondolfi, Alberto, additional, Risquez, Alejandro, additional, Forero-Peña, David A., additional, Torres, Jaime R., additional, and Suarez, Jose Antonio, additional

Published
2022
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27. Use of remdesivir in patients with COVID-19: a systematic review and meta-analysis

Author

Tanni, Suzana E, Silvinato, Antonio, Floriano, Idevaldo, Bacha, Hélio A, Barbosa, Alexandre Naime, and Bernardo, Wanderley M

Subjects
Antiviral agents, SARS-CoV-2, COVID-19, Antivirais
Abstract

Objective: Studies in the literature regarding the use of remdesivir to treat COVID-19 patients have shown conflicting results. This study sought to answer questions related to the use of remdesivir for the treatment of patients hospitalized with moderate to severe COVID-19. Methods: This was a systematic review and meta-analysis including phase 3 randomized clinical trials (RCTs) and observational cohort studies selected from various databases, comparing patients hospitalized with moderate to severe COVID-19 receiving remdesivir and controls. Results: A total of 207 studies were retrieved, 9 of which met the eligibility criteria and were included in the study. The meta-analysis using RCTs alone showed no statistically significant differences regarding mortality or use of mechanical ventilation/extracorporeal membrane oxygenation between remdesivir and control groups, and the quality of evidence was moderate and low, respectively. The use of remdesivir increased the recovery rate by 6% (95% CI, 3-9); p = 0.004) and the clinical improvement rate by 7% (95% CI, 1-14); p = 0.02). Additionally, no significant differences in mortality were found between remdesivir and control groups when the meta-analysis used observational cohort studies alone (risk difference = −0.01 (95% CI, −0.02 to 0.01; p = 0.32), the quality of evidence being moderate, and the risk of adverse events was 4% ([95% CI, −0.08 to 0.01]; p = 0.09). Conclusions: The use of remdesivir for the treatment of patients with moderate to severe COVID-19 had no significant impact on clinically important outcomes. RESUMO Objetivo: Estudos na literatura sobre o uso de remdesivir no tratamento de pacientes com COVID-19 têm apresentado resultados divergentes. O objetivo deste estudo foi responder a perguntas a respeito do uso de remdesivir no tratamento de pacientes hospitalizados com COVID-19 moderada a grave. Métodos: Trata-se de uma revisão sistemática e meta-análise de ensaios clínicos controlados randomizados (ECR) de fase 3 e estudos observacionais de coorte recuperados de diversos bancos de dados, comparando pacientes hospitalizados com COVID-19 moderada a grave recebendo remdesivir a controles. Resultados: Foram recuperados 207 estudos, dos quais 9 preencheram os critérios de elegibilidade e foram incluídos no estudo. A meta-análise somente dos ECR não mostrou diferenças estatisticamente significativas entre os grupos remdesivir e controle quanto à mortalidade ou ao uso de ventilação mecânica/oxigenação por membrana extracorpórea, e a qualidade das evidências foi moderada e baixa, respectivamente. O uso de remdesivir aumentou a taxa de recuperação em 6% (IC95%: 3-9; p = 0,004) e a taxa de melhora clínica em 7% (IC95%: 1-14; p = 0,02). Além disso, não foram observadas diferenças significativas entre os grupos remdesivir e controle quanto à mortalidade quando a meta-análise concentrou-se apenas nos estudos observacionais de coorte [diferença de risco = −0,01 (IC95%: −0,02 a 0,01); p = 0,32; qualidade das evidências: moderada], e o risco de eventos adversos foi de 4% (IC95%: −0,08 a 0,01; p = 0,09). Conclusões: O uso de remdesivir no tratamento de pacientes com COVID-19 moderada a grave não teve impacto significativo em desfechos clinicamente importantes.

Published
2022

30. Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: A case report

Author

Menegali,Bruno Thizon, Schuelter-Trevisol,Fabiana, Barbosa,Alexandre Naime, Izidoro,Talita Menegali, Feurschuette,Otto Henrique May, Marcon,Chaiana Esmeraldino Mendes, and Trevisol,Daisson José

Subjects
viruses, virus diseases, Coronavirus infections, biochemical phenomena, metabolism, and nutrition, Vaccine, Immunization passive
Abstract

The use of coronavirus disease 2019 RNA vaccines in pregnant women led to reports on the first cases of newborns with antibodies to sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a phenomenon that was unknown when using immunizations with inactivated viruses. Thus, this study aimed to report a case of passive anti-SARS-CoV-2 immunity in a newborn through immunoprophylaxis of a pregnant woman who received the CoronaVac® vaccine in the third trimester of pregnancy. Twenty-four hours after delivery, samples were collected from the newborn and screened by enzyme immunoassays, which revealed antibodies to SARS-CoV-2.

Published
2021

32. Comments on the Pathophysiological Basis and Rationale for Early Treatment of COVID-19

Author

Weissmann, Leonardo, primary, Barbosa, Alexandre Naime, additional, Scarpellini, Bruno, additional, Diament, Décio, additional, Medeiros, Eduardo Alexandrino, additional, Silva, Estevão Urbano, additional, Morejón, Karen Mirna Loro, additional, Oliveira, Priscila Rosalba Domingos, additional, Stucchi, Raquel Silveira Bello, additional, Medeiros, Roseane Porto, additional, Cimerman, Sérgio, additional, Vergara, Tânia Regina Constant, additional, and Cunha, Clóvis Arns, additional

Published
2021
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33. Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom

Author

Barbosa, Alexandre Naime, primary, Ferreira, Rui Seabra, additional, de Carvalho, Francilene Capel Tavares, additional, Schuelter-Trevisol, Fabiana, additional, Mendes, Mônica Bannwart, additional, Mendonça, Bruna Cavecci, additional, Batista, José Nixon, additional, Trevisol, Daisson José, additional, Boyer, Leslie, additional, Chippaux, Jean-Philippe, additional, Medolago, Natália Bronzatto, additional, Cassaro, Claudia Vilalva, additional, Carneiro, Márcia Tonin Rigotto, additional, de Oliveira, Ana Paola Piloto, additional, Pimenta, Daniel Carvalho, additional, da Cunha, Luís Eduardo Ribeiro, additional, Santos, Lucilene Delazari dos, additional, and Barraviera, Benedito, additional

Published
2021
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34. A phase I/II trial to treat massive Africanized honeybee (Apis mellifera) stings using the new apilic antivenom

Author

Barbosa, Alexandre Naime, primary, Ferreira, Rui Seabra, additional, de Carvalho, Francilene Capel Tavares, additional, Schuelter-Trevisol, Fabiana, additional, Mendes, Mônica Bannwart, additional, Mendonça, Bruna Cavecci, additional, Batista, José Nixon, additional, José Trevisol, Daisson, additional, Boyer, Leslie, additional, Chippaux, Jean-Philippe, additional, Medolago, Natália Bronzatto, additional, Cassaro, Claudia Vilalva, additional, Rigotto Carneiro, Márcia Tonin, additional, de Oliveira, Ana Paola Piloto, additional, Pimenta, Daniel Carvalho, additional, da Cunha, Luís Eduardo Ribeiro, additional, dos Santos, Lucilene Delazari, additional, and Barraviera, Benedito, additional

Published
2021
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42. Human blood venom levels after Africanized honey bee (Apis mellifera) massive attack and its degradomic aspects

Author

Tavares, Francilene Capel, primary, De Oliveira, Laudicéia Alves, additional, Barbosa, Alexandre Naime, additional, Mendes, Monica Bannwart, additional, Pimenta, Daniel Carvalho, additional, Medolago, Natalia, additional, Oliveira, Ana Paula, additional, Carneiro, Márcia, additional, Ribeiro Da Cunha, Luis Eduardo, additional, Carvalho, Edimilson R.M., additional, Trevisol, Fabiana Schuelter, additional, Trevisol, Daisson J., additional, Batista, José N., additional, Ferreira, Rui Seabra, additional, Barraviera, Benedito, additional, and Dos Santos, Lucilene Delazari, additional

Published
2019
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44. ALTÍSSIMA TAXA DE RESPOSTA TERAPÊUTICA DA HEPATITE C EM UMA COORTE DE VIDA REAL NO BRASIL

Author

Bertucci, Alexandre Albuquerqu, primary, Macedo, Bruno Cardoso, additional, Proença, Stephanie V.F., additional, Antonelli, Thaysa Sobral, additional, Pernomian, Laura Sambugaro, additional, Rêgo, Amanda B.G.C., additional, Rodrigues, Beatriz Gomes, additional, Corrêa, Gabriel Faria, additional, Cortês, Lucas Silva, additional, Norcia, Luiz Fernando, additional, Andreotti, Paolo, additional, and Barbosa, Alexandre Naime, additional

Published
2018
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48. Contributory role of ART in the development of non-AIDS comorbidities in asymptomatic PLWHA.

Author

Tasca, Karen Ingrid, Vidal, Vânia V. M. Fagundes, Manfio, Vanessa Martinez, Barbosa, Alexandre Naime, and de Souza, Lenice do Rosârio

Subjects
ANTIRETROVIRAL agents, DYSLIPIDEMIA, HIV, MEDICINE, AIDS
Abstract

Background: Despite the many benefits that follow antiretroviral therapy (ART) initiation, its chronic use contributes to the early aging of people living with HIV/AIDS (PLWHA). The aim of this cross-sectional study was to trace the prevalence of and investigate possible renal, bone and metabolic changes, as well as cardiovascular risk in 94 asymptomatic PLWHA, relating them to the duration of ART use. Methods: Four groups were evaluated according to ART use: G1 (n = 21), ART-naïve individuals; G2 (n = 17), <2 years; G3 (n = 40), 2-10 years; and G4 (n = 16) on ART for more than 10 years. Results: Our results showed a high prevalence of dyslipidemic individuals (64%), especially in those under ART. Lower creatine phosphokinase levels were observed in G1 as compared to the others (p < 0.05). Regarding the Framingham score, 12.1% of PLWHA showed moderate and high risk, and the highest proportion (38.5%) occurred in G4 (p = 0.003). A decrease in glomerular filtration rates occurred in 20% of patients, which was also more significant in G3 and G4 (p = 0.007). High prevalences of osteopenia and osteoporosis (53.2%) were found, especially in G1 and G4; however, G1 showed the lowest means for alkaline phosphatases (AP, p = 0.04 and BAP, p = 0.005) and osteocalcin (p = 0.005), in addition to higher vitamin-D concentrations (p = 0.04). Conclusions: Our study showed the possible contributory role of ART in these changes, which leads us to reflect on the need for specific conducts and patient care, pointing out the importance of individualized care in an attempt to increase life expectancy. [ABSTRACT FROM AUTHOR]

Published
2021
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49. A clinical trial protocol to treat massive Africanized honeybee (Apis mellifera) attack with a new apilic antivenom

Author

Barbosa, Alexandre Naime, primary, Boyer, Leslie, additional, Chippaux, Jean-Philippe, additional, Medolago, Natalia Bronzatto, additional, Caramori, Carlos Antonio, additional, Paixão, Ariane Gomes, additional, Poli, João Paulo Vasconcelos, additional, Mendes, Mônica Bannwart, additional, dos Santos, Lucilene Delazari, additional, Ferreira, Rui Seabra, additional, and Barraviera, Benedito, additional

Published
2017
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