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3. Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies: A cross-sectional multi-country study

Author

Desalegn, Anteneh, Schillemans, Tessa, Papadopoulou, Eleni, Sakhi, Amrit K., Haug, Line S., Henriette Caspersen, Ida, Rodriguez-Carrillo, Andrea, Remy, Sylvie, Schoeters, Greet, Covaci, Adrian, Laeremans, Michelle, Fernández, Mariana F, Pedraza-Diaz, Susana, Kold Jensen, Tina, Frederiksen, Hanne, Åkesson, Agneta, Cox, Bianca, Cynthia D’Cruz, Shereen, Rambaud, Loïc, Riou, Margaux, Kolossa-Gehring, Marike, Gerofke, Antje, Murawski, Aline, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Dimosthenis, Barbone, Fabio, Rosolen, Valentina, Lignell, Sanna, Karin Lindroos, Anna, Snoj Tratnik, Janja, Stajnko, Anja, Kosjek, Tina, Tkalec, Žiga, Fabelova, Lucia, Palkovicova Murinova, Lubica, Kolena, Branislav, Wimmerova, Sona, Szigeti, Tamás, Középesy, Szilvia, van den Brand, Annick, Zock, Jan-Paul, Janasik, Beata, Wasowicz, Wojciech, De Decker, Annelies, De Henauw, Stefaan, Govarts, Eva, and Iszatt, Nina

Published
2024
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6. Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the “European Human Biomonitoring Initiative” HBM4EU participating studies

Author

F. Fernández, Sandra, Poteser, Michael, Govarts, Eva, Pardo, Olga, Coscollà, Clara, Schettgen, Thomas, Vogel, Nina, Weber, Till, Murawski, Aline, Kolossa-Gehring, Marike, Rüther, Maria, Schmidt, Phillipp, Namorado, Sónia, Van Nieuwenhuyse, An, Appenzeller, Brice, Ólafsdóttir, Kristín, Halldorsson, Thorhallur I., Haug, Line S., Thomsen, Cathrine, Barbone, Fabio, Mariuz, Marika, Rosolen, Valentina, Rambaud, Loïc, Riou, Margaux, Göen, Thomas, Nübler, Stefanie, Schäfer, Moritz, Zarrabi, Karin H. A., Sepai, Ovnair, Martin, Laura Rodriguez, Schoeters, Greet, Gilles, Liese, Leander, Karin, Moshammer, Hanns, Akesson, Agneta, and Laguzzi, Federica

Published
2023
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8. Examining potential Long COVID effects through utilization of healthcare resources: a retrospective, population-based, matched cohort study comparing individuals with and without prior SARS-CoV-2 infection

Author

Castriotta, Luigi, primary, Onder, Graziano, additional, Rosolen, Valentina, additional, Beorchia, Yvonne, additional, Fanizza, Caterina, additional, Bellini, Benedetta, additional, Floridia, Marco, additional, Giuliano, Marina, additional, Silenzi, Andrea, additional, Pricci, Flavia, additional, Grisetti, Tiziana, additional, Grassi, Tiziana, additional, Tiple, Dorina, additional, Villa, Marika, additional, Profili, Francesco, additional, Francesconi, Paolo, additional, Barbone, Fabio, additional, Bisceglia, Lucia, additional, and Brusaferro, Silvio, additional

Published
2024
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9. Insight into Potential Long COVID Effects: Antidepressant Use in Post SARS-CoV-2 Infection Scenarios. A Multiregional Nested Case-Control Study

Author

Rosolen, Valentina, primary, Beorchia, Yvonne, additional, Castriotta, Luigi, additional, Fanizza, Caterina, additional, Profili, Francesco, additional, Floridia, Marco, additional, Giuliano, Marina, additional, Pricci, Flavia, additional, Villa, Marika, additional, Grisetti, Tiziana, additional, Grassi, Tiziana, additional, Tiple, Dorina, additional, Silenzi, Andrea, additional, Francesconi, Paolo, additional, Bisceglia, Lucia, additional, Barbone, Fabio, additional, Brusaferro, Silvio, additional, and Onder, Graziano, additional

Published
2024
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10. Clinical outcomes of thermal ablation retreatment of benign thyroid nodules: A multicenter study from the Italian minimally-invasive treatments of the thyroid group

Author

Bernardi, Stella, primary, Rosolen, Valentina, additional, Barbone, Fabio, additional, Borgato, Stefano, additional, Deandrea, Maurilio, additional, De Feo, Pierpaolo, additional, Fugazzola, Laura, additional, Gambelunghe, Giovanni, additional, Negro, Roberto, additional, Oleandri, Salvatore, additional, Papi, Giampaolo, additional, Papini, Enrico, additional, Retta, Francesca, additional, rossetto, ruth, additional, Sansone, Daniela, additional, Serra, Giuseppe, additional, Sconfienza, Luca Maria, additional, Solbiati, Luigi, additional, Spiezia, Stefano, additional, Stacul, Fulvio, additional, and Mauri, Giovanni, additional

Published
2023
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12. Cognitive Performance and Exposure to Organophosphate Flame Retardants in Children: Evidence from a Cross-Sectional Analysis of Two European Mother–Child Cohorts

Author

Rosolen, Valentina, primary, Giordani, Elisa, additional, Mariuz, Marika, additional, Parpinel, Maria, additional, Mustieles, Vicente, additional, Gilles, Liese, additional, Govarts, Eva, additional, Rodriguez Martin, Laura, additional, Baken, Kirsten, additional, Schoeters, Greet, additional, Sepai, Ovnair, additional, Sovcikova, Eva, additional, Fabelova, Lucia, additional, Kohoutek, Jiři, additional, Jensen, Tina Kold, additional, Covaci, Adrian, additional, Roggeman, Maarten, additional, Melymuk, Lisa, additional, Klánová, Jana, additional, Castano, Argelia, additional, Esteban López, Marta, additional, and Barbone, Fabio, additional

Published
2023
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13. Cause specific mortality in an Italian pool of asbestos workers cohorts

Author

Ferrante, Daniela, primary, Angelini, Alessia, additional, Barbiero, Fabiano, additional, Barbone, Fabio, additional, Bauleo, Lisa, additional, Binazzi, Alessandra, additional, Bovenzi, Massimo, additional, Bruno, Caterina, additional, Casotto, Veronica, additional, Cernigliaro, Achille, additional, Ceppi, Marcello, additional, Cervino, Daniela, additional, Chellini, Elisabetta, additional, Curti, Stefania, additional, De Santis, Marco, additional, Fazzo, Lucia, additional, Fedeli, Ugo, additional, Fiorillo, Germano, additional, Franchi, Alberto, additional, Gangemi, Manuela, additional, Giangreco, Manuela, additional, Rossi, Paolo Giorgi, additional, Girardi, Paolo, additional, Luberto, Ferdinando, additional, Massari, Stefania, additional, Mattioli, Stefano, additional, Menegozzo, Simona, additional, Merlo, Domenico Franco, additional, Michelozzi, Paola, additional, Migliore, Enrica, additional, Miligi, Lucia, additional, Oddone, Enrico, additional, Pernetti, Roberta, additional, Perticaroli, Patrizia, additional, Piro, Sara, additional, Addario, Sebastiano Pollina, additional, Romeo, Elisa, additional, Roncaglia, Francesca, additional, Silvestri, Stefano, additional, Storchi, Cinzia, additional, Zona, Amerigo, additional, Magnani, Corrado, additional, and Marinaccio, Alessandro, additional

Published
2023
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16. Clinical Outcomes of Thermal Ablation Re-Treatment of Benign Thyroid Nodules: A Multicenter Study from the Italian Minimally Invasive Treatments of the Thyroid Group.

Author

Bernardi, Stella, Rosolen, Valentina, Barbone, Fabio, Borgato, Stefano, Deandrea, Maurilio, De Feo, Pierpaolo, Fugazzola, Laura, Gambelunghe, Giovanni, Negro, Roberto, Oleandri, Salvatore, Papi, Giampaolo, Papini, Enrico, Retta, Francesca, Rossetto, Ruth, Sansone, Daniela, Serra, Giuseppe, Sconfienza, Luca Maria, Solbiati, Luigi, Spiezia, Stefano, and Stacul, Fulvio

Subjects
THYROID nodules, TREATMENT effectiveness, THYROID cancer, CATHETER ablation, THYROID gland, CONFIDENCE intervals
Abstract

Background: Thermal ablation (TA) is an established therapeutic option alternative to surgery in patients with solid benign thyroid nodules causing local symptoms. However, a variable part of thyroid nodules remain viable after these nonsurgical treatments, and as many as 15% of nodules treated with TA may require a second treatment over time. This study aimed to evaluate the outcomes of TA re-treatment on symptomatic benign thyroid nodules where the volume decreased by <50% after the first procedure ( = technique inefficacy). Methods: We performed a multicenter retrospective cohort study including patients who underwent re-treatment with TA for benign thyroid nodules, whose volume decreased by <50% after initial treatment. The primary aim was to evaluate volume and volume reduction ratio (VRR) over time and compare the 6- and 12-month VRR after first versus second treatment. The secondary aim was to identify protective or risk factors for technique inefficacy, regrowth, and further treatments, expressed as adjusted hazard ratios (HRs) and confidence interval [CI], after adjustment for sex, age, nodule volume, structure and function, nodule regrowth or symptom relapse, technique used and if the same technique was used for the first and second TA and time between them. Results: We included 135 patients. Re-treatment led to VRR of 50% and 52.2% after 6 and 12 months. VRR after re-treatment was greater than after first treatment in small and medium size nodules (<30 mL), while there were no differences for large nodules (>30 mL). After re-treatment technique inefficacy rate was 51.9%, regrowth rate was 12.6%, and further treatment rate was 15.6%. Radiofrequency ablation (RFA) was protective toward technique inefficacy (HR = 0.40 [CI 0.24–0.65]) and need of further treatments (HR = 0.30 [CI 0.12–0.76]). Large nodule volume (>30 mL) was associated with increased risk of re-treatment (HR = 4.52 [CI 1.38–14.82]). Conclusions: This is the first study evaluating the outcomes of re-treatment on symptomatic benign thyroid nodules with a VRR <50% after the initial TA treatment. Best results were seen in small and medium nodules (<30 mL) and after RFA. Prospective confirmatory studies are needed. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Cause specific mortality in an Italian pool of asbestos workers cohorts.

Author

Ferrante, Daniela, Angelini, Alessia, Barbiero, Fabiano, Barbone, Fabio, Bauleo, Lisa, Binazzi, Alessandra, Bovenzi, Massimo, Bruno, Caterina, Casotto, Veronica, Cernigliaro, Achille, Ceppi, Marcello, Cervino, Daniela, Chellini, Elisabetta, Curti, Stefania, De Santis, Marco, Fazzo, Lucia, Fedeli, Ugo, Fiorillo, Germano, Franchi, Alberto, and Gangemi, Manuela

Abstract

Background: Asbestos is a known human carcinogen and is causally associated with malignant mesothelioma, lung, larynx and ovarian cancers. Methods: Cancer risk was studied among a pool of formerly asbestos‐exposed workers in Italy. Fifty‐two Italian asbestos cohorts (asbestos‐cement, rolling‐stock, shipbuilding, and other) were pooled and their mortality follow‐up was updated to 2018. Standardized mortality ratios (SMRs) were computed for major causes of death considering duration of exposure and time since first exposure (TSFE), using reference rates by region, age and calendar period. Results: The study included 63,502 subjects (57,156 men and 6346 women): 40% who were alive, 58% who died (cause known for 92%), and 2% lost to follow‐up. Mortality was increased for all causes (SMR: men = 1.04, 95% confidence interval [CI] 1.03−1.05; women = 1.15, 95% CI 1.11−1.18), all malignancies (SMR: men = 1.21, 95% CI 1.18−1.23; women = 1.29, 95% CI 1.22−1.37), pleural and peritoneal malignancies (men: SMR = 10.46, 95% CI 9.86−11.09 and 4.29, 95% CI 3.66−5.00; women: SMR = 27.13, 95% CI 23.29−31.42 and 7.51, 95% CI 5.52−9.98), lung (SMR: men = 1.28, 95% CI 1.24−1.32; women = 1.26, 95% CI 1.02−1.53), and ovarian cancer (SMR = 1.42, 95% CI 1.08−1.84). Pleural cancer mortality increased during the first 40 years of TSFE (latency), reaching a plateau thereafter. Conclusions: Analyses by time‐dependent variables showed that the risk for pleural neoplasms increased with latency and no longer increases at long TSFE, consistent with with asbestos clearance from the lungs. Peritoneal neoplasm risk increased over all observation time. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe

Author

Rodriguez Martin, Laura Rodriguez, primary, Gilles, Liese, additional, Helte, Emilie, additional, Åkesson, Agneta, additional, Tägt, Jonas, additional, Covaci, Adrian, additional, Sakhi, Amrit K., additional, Van Nieuwenhuyse, An Van, additional, Katsonouri, Andromachi, additional, Andersson, Anna-Maria, additional, Gutleb, Arno C., additional, Janasik, Beata, additional, Appenzeller, Brice, additional, Gabriel, Catherine, additional, Thomsen, Cathrine, additional, Mazej, Darja, additional, Sarigiannis, Denis, additional, Anastasi, Elena, additional, Barbone, Fabio, additional, Tolonen, Hanna, additional, Frederiksen, Hanne, additional, Klanova, Jana, additional, Koponen, Jani, additional, Tratnik, Janja Snoj, additional, Pack, Kim, additional, Gudrun, Koppen, additional, Ólafsdóttir, Kristin, additional, Knudsen, Lisbeth, additional, Rambaud, Loïc, additional, Strumylaite, Loreta, additional, Murinova, Lubica Palkovicova, additional, Fabelova, Lucia, additional, Riou, Margaux, additional, Berglund, Marika, additional, Szabados, Maté, additional, Imboden, Medea, additional, Laeremans, Michelle, additional, Eštóková, Milada, additional, Holcer, Natasa Janev, additional, Probst-Hensch, Nicole, additional, Vodrazkova, Nicole, additional, Vogel, Nina, additional, Piler, Pavel, additional, Schmidt, Phillipp, additional, Lange, Rosa, additional, Namorado, Sónia, additional, Kozepesy, Szilvia, additional, Szigeti, Tamás, additional, Halldorsson, Thorhallur I., additional, Weber, Till, additional, Jensen, Tina Kold, additional, Rosolen, Valentina, additional, Puklova, Vladimira, additional, Wasowicz, Wojciech, additional, Sepai, Ovnair, additional, Stewart, Lorraine, additional, Kolossa-Gehring, Marike, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Bessems, Jos, additional, Schoeters, Greet, additional, and Govarts, Eva, additional

Published
2023
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22. Current exposure to phthalates and DINCH in European children and adolescents – Results from the HBM4EU Aligned Studies 2014 to 2021

Author

Vogel, Nina, primary, Schmidt, Phillipp, additional, Lange, Rosa, additional, Gerofke, Antje, additional, Sakhi, Amrit K., additional, Haug, Line S., additional, Jensen, Tina Kold, additional, Frederiksen, Hanne, additional, Szigeti, Tamás, additional, Csákó, Zsófia, additional, Murinova, Lubica Palkovicova, additional, Sidlovska, Miroslava, additional, Janasik, Beata, additional, Wasowicz, Wojciech, additional, Tratnik, Janja Snoj, additional, Mazej, Darja, additional, Gabriel, Catherine, additional, Karakitsios, Spyros, additional, Barbone, Fabio, additional, Rosolen, Valentina, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Murawski, Aline, additional, Leseman, Daan, additional, Koppen, Gudrun, additional, Covaci, Adrian, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Zvonar, Martin, additional, Andryskova, Lenka, additional, Fabelova, Lucia, additional, Richterova, Denisa, additional, Horvat, Milena, additional, Kosjek, Tina, additional, Sarigiannis, Denis, additional, Maroulis, Marios, additional, Pedraza-Diaz, Susana, additional, Cañas, Ana, additional, Verheyen, Veerle J., additional, Bastiaensen, Michiel, additional, Gilles, Liese, additional, Schoeters, Greet, additional, Esteban-López, Marta, additional, Castaño, Argelia, additional, Govarts, Eva, additional, Koch, Holger M., additional, and Kolossa-Gehring, Marike, additional

Published
2023
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23. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author

Govarts, Eva, primary, Gilles, Liese, additional, Rodriguez Martin, Laura, additional, Santonen, Tiina, additional, Apel, Petra, additional, Alvito, Paula, additional, Anastasi, Elena, additional, Andersen, Helle Raun, additional, Andersson, Anna-Maria, additional, Andryskova, Lenka, additional, Antignac, Jean-Philippe, additional, Appenzeller, Brice, additional, Barbone, Fabio, additional, Barnett-Itzhaki, Zohar, additional, Barouki, Robert, additional, Berman, Tamar, additional, Bil, Wieneke, additional, Borges, Teresa, additional, Buekers, Jurgen, additional, Cañas-Portilla, Ana, additional, Covaci, Adrian, additional, Csako, Zsofia, additional, Den Hond, Elly, additional, Dvorakova, Darina, additional, Fabelova, Lucia, additional, Fletcher, Tony, additional, Frederiksen, Hanne, additional, Gabriel, Catherine, additional, Ganzleben, Catherine, additional, Göen, Thomas, additional, Halldorsson, Thorhallur I., additional, Haug, Line S., additional, Horvat, Milena, additional, Huuskonen, Pasi, additional, Imboden, Medea, additional, Jagodic Hudobivnik, Marta, additional, Janasik, Beata, additional, Janev Holcer, Natasa, additional, Karakitsios, Spyros, additional, Katsonouri, Andromachi, additional, Klanova, Jana, additional, Kokaraki, Venetia, additional, Kold Jensen, Tina, additional, Koponen, Jani, additional, Laeremans, Michelle, additional, Laguzzi, Federica, additional, Lange, Rosa, additional, Lemke, Nora, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Lobo Vicente, Joana, additional, Luijten, Mirjam, additional, Makris, Konstantinos C., additional, Mazej, Darja, additional, Melymuk, Lisa, additional, Meslin, Matthieu, additional, Mol, Hans, additional, Montazeri, Parisa, additional, Murawski, Aline, additional, Namorado, Sónia, additional, Niemann, Lars, additional, Nübler, Stefanie, additional, Nunes, Baltazar, additional, Olafsdottir, Kristin, additional, Palkovicova Murinova, Lubica, additional, Papaioannou, Nafsika, additional, Pedraza-Diaz, Susana, additional, Piler, Pavel, additional, Plichta, Veronika, additional, Poteser, Michael, additional, Probst-Hensch, Nicole, additional, Rambaud, Loïc, additional, Rauscher-Gabernig, Elke, additional, Rausova, Katarina, additional, Remy, Sylvie, additional, Riou, Margaux, additional, Rosolen, Valentina, additional, Rousselle, Christophe, additional, Rüther, Maria, additional, Sarigiannis, Denis, additional, Silva, Maria J., additional, Šlejkovec, Zdenka, additional, Snoj Tratnik, Janja, additional, Stajnko, Anja, additional, Szigeti, Tamas, additional, Tarazona, José V., additional, Thomsen, Cathrine, additional, Tkalec, Žiga, additional, Tolonen, Hanna, additional, Trnovec, Tomas, additional, Uhl, Maria, additional, Van Nieuwenhuyse, An, additional, Vasco, Elsa, additional, Verheyen, Veerle J., additional, Viegas, Susana, additional, Vinggaard, Anne Marie, additional, Vogel, Nina, additional, Vorkamp, Katrin, additional, Wasowicz, Wojciech, additional, Weber, Till, additional, Wimmerova, Sona, additional, Woutersen, Marjolijn, additional, Zimmermann, Philipp, additional, Zvonar, Martin, additional, Koch, Holger, additional, Kolossa-Gehring, Marike, additional, Esteban López, Marta, additional, Castaño, Argelia, additional, Stewart, Lorraine, additional, Sepai, Ovnair, additional, and Schoeters, Greet, additional

Published
2023
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24. Levels of Ethylenethiourea (u-ETU) in a Population Living Near Vineyards

Author

Sammartano, Francesca, Castriotta, Luigi, Chermaz, Ester, Moro, Giovanni, Bolzan, Sabina, Bortoletto, Martina, Little, D’Anna, Bartolucci, Giovanni, Carrieri, Mariella, Salamon, Fabiola, Bravo, Giulia, Cinquetti, Sandro, and Barbone, Fabio

Abstract

Dithiocarbamates (DTC) are the most commonly used synthetic fungicides in the Prosecco District (PD) of Treviso. The DTC biomarker is urinary ethylenethiourea (u-ETU). The aims of this biomonitoring study are to describe the level of u-ETU in residents in PD and to identify the factors associated with DTC exposure. In 2012 (baseline), we randomly extracted data for 126 children (3–5 years) and their families (260 adults), who were resident in 8 municipalities of PD and not occupationally exposed to DTC, from the local health database. For each subject, we obtained urine samples and socio-demographic, lifestyle and dietary information. In 2014 (after intervention), we evaluated the possible changes in u-ETU in 54 adults and 55 children at high risk of DTC exposure. The median baseline u-ETU was 0.35 µg/L. Approximately 5% of the samples had a u-ETU concentration > 5 µg/L. No u-ETU concentration exceeded 21 µg/L. Determinants of a higher u-ETU concentration were wine consumption (OR 2.04) and personal use of pesticides (OR 2.70) for adults; and living within 30 m from a vineyard (OR 9.51) and the pesticides use in the family (OR 6.25) for children. A significant u-ETU reduction in 49 adults and 25 children was observed from baseline to after intervention (p= 0.01). Wine consumption and production and DTC use in gardening influenced u-ETU concentrations in this population, although the levels were relatively low. The reduction in u-ETU from baseline to time after intervention probably reflects the effects of public health interventions.

Published
2024
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25. From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author

IRAS OH Epidemiology Chemical Agents, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J, Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E, Koch, Holger M, Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C, Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, Kolossa-Gehring, Marike, IRAS OH Epidemiology Chemical Agents, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J, Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E, Koch, Holger M, Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C, Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, and Kolossa-Gehring, Marike

Published
2023

26. Harmonized human biomonitoring in European children, teenagers and adults:EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

Author

Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, Antignac, Jean-Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I, Haug, Line S, Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C, Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J, Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, Antignac, Jean-Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I, Haug, Line S, Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C, Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J, Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, and Schoeters, Greet

Abstract

As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educat

Published
2023

27. Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe

Author

Rodriguez Martin, Laura, Gilles, Liese, Helte, Emilie, Åkesson, Agneta, Tägt, Jonas, Covaci, Adrian, Sakhi, Amrit K., Van Nieuwenhuyse, An, Katsonouri, Andromachi, Andersson, Anna Maria, Gutleb, Arno C., Janasik, Beata, Appenzeller, Brice, Gabriel, Catherine, Thomsen, Cathrine, Mazej, Darja, Sarigiannis, Denis, Anastasi, Elena, Barbone, Fabio, Tolonen, Hanna, Frederiksen, Hanne, Klanova, Jana, Koponen, Jani, Tratnik, Janja Snoj, Pack, Kim, Gudrun, Koppen, Ólafsdóttir, Kristin, Knudsen, Lisbeth E., Rambaud, Loïc, Strumylaite, Loreta, Murinova, Lubica Palkovicova, Fabelova, Lucia, Riou, Margaux, Berglund, Marika, Szabados, Maté, Imboden, Medea, Laeremans, Michelle, Eštóková, Milada, Janev Holcer, Natasa, Probst-Hensch, Nicole, Vodrazkova, Nicole, Vogel, Nina, Piler, Pavel, Schmidt, Phillipp, Lange, Rosa, Namorado, Sónia, Kozepesy, Szilvia, Szigeti, Tamás, Halldorsson, Thorhallur I., Weber, Till, Jensen, Tina Kold, Rosolen, Valentina, Puklova, Vladimira, Wasowicz, Wojciech, Sepai, Ovnair, Stewart, Lorraine, Kolossa-Gehring, Marike, Esteban-López, Marta, Castaño, Argelia, Bessems, Jos, Schoeters, Greet, Govarts, Eva, Rodriguez Martin, Laura, Gilles, Liese, Helte, Emilie, Åkesson, Agneta, Tägt, Jonas, Covaci, Adrian, Sakhi, Amrit K., Van Nieuwenhuyse, An, Katsonouri, Andromachi, Andersson, Anna Maria, Gutleb, Arno C., Janasik, Beata, Appenzeller, Brice, Gabriel, Catherine, Thomsen, Cathrine, Mazej, Darja, Sarigiannis, Denis, Anastasi, Elena, Barbone, Fabio, Tolonen, Hanna, Frederiksen, Hanne, Klanova, Jana, Koponen, Jani, Tratnik, Janja Snoj, Pack, Kim, Gudrun, Koppen, Ólafsdóttir, Kristin, Knudsen, Lisbeth E., Rambaud, Loïc, Strumylaite, Loreta, Murinova, Lubica Palkovicova, Fabelova, Lucia, Riou, Margaux, Berglund, Marika, Szabados, Maté, Imboden, Medea, Laeremans, Michelle, Eštóková, Milada, Janev Holcer, Natasa, Probst-Hensch, Nicole, Vodrazkova, Nicole, Vogel, Nina, Piler, Pavel, Schmidt, Phillipp, Lange, Rosa, Namorado, Sónia, Kozepesy, Szilvia, Szigeti, Tamás, Halldorsson, Thorhallur I., Weber, Till, Jensen, Tina Kold, Rosolen, Valentina, Puklova, Vladimira, Wasowicz, Wojciech, Sepai, Ovnair, Stewart, Lorraine, Kolossa-Gehring, Marike, Esteban-López, Marta, Castaño, Argelia, Bessems, Jos, Schoeters, Greet, and Govarts, Eva

Abstract

Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. For 2014–2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5–12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24–52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM. Keywords: human biomonitoring; hazardous chemical; phthalates; DINCH; OPFRs; cadmium; PAHs; bisphenols, Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. For 2014–2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5–12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24–52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM.

Published
2023

28. From science to policy:How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author

Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan Paul, Schoeters, Greet, Kolossa-Gehring, Marike, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan Paul, Schoeters, Greet, and Kolossa-Gehring, Marike

Abstract

Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014–2021), the usefulness of our indicators was demonstrated for the age group children (6–11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12–18 years), and time periods were compared using data from the DEMOCOPHES project (2011–2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differences., Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014–2021), the usefulness of our indicators was demonstrated for the age group children (6–11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12–18 years), and time periods were compared using data from the DEMOCOPHES project (2011–2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differenc

Published
2023

29. Harmonized human biomonitoring in European children, teenagers and adults : EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author

Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, and Schoeters, Greet

Abstract

As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educat

Published
2023

31. Retrospective study 2005–2015 of all cases of fetal death occurred at ≥23 gestational weeks, in Friuli Venezia Giulia, Italy

Author

Monasta, Lorenzo, Giangreco, Manuela, Ancona, Emanuele, Barbone, Fabio, Bet, Elisa, Boschian-Bailo, Pierino, Cacciaguerra, Giovanna, Cagnacci, Angelo, Canton, Melania, Casarotto, Maddalena, Comar, Manola, Contardo, Simona, De Agostini, Michela, De Seta, Francesco, Del Ben, Giovanni, Di Loreto, Carla, Driul, Lorenza, Facchin, Stefano, Giornelli, Roberta, Ianni, Annalisa, La Valle, Santo, Londero, Ambrogio Pietro, Manfè, Marciano, Maso, Gianpaolo, Mugittu, Raffaela, Olivuzzi, Monica, Orsaria, Maria, Pecile, Vanna, Pinzano, Roberta, Pirrone, Francesco, Quadrifoglio, Mariachiara, Ricci, Giuseppe, Ronfani, Luca, Salviato, Tiziana, Sandrigo, Elisa, Smiroldo, Silvia, Sorz, Alice, Stampalija, Tamara, Urriza, Marianela, Vanin, Michele, Verardi, Giuseppina, and Alberico, Salvatore

Published
2020
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32. EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author

Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
HBM4EU, SDG 3 - Good Health and Well-being, Public Health, Environmental and Occupational Health, Adults, Exposure biomarkers, Children, Teenagers, Human biomonitoring (HBM)
Abstract

Funding Information: The authors would like to thank everybody who contributed to the HBM4EU Aligned Studies: the participating children, teenagers, adults and their families, the fieldworkers that collected the samples and database managers that made the information available to HBM4EU, the HBM4EU project partners, especially those from WP7 for developing all materials supporting the fieldwork, WP9 for organizing the QA/QC scheme under HBM4EU and all laboratories who performed the analytical measurements. We would like to acknowledge Sun Kyoung Jung from the National Institute of Environmental Research of South-Korea for providing the KoNEHS Cycle III results (crt adjusted). HBM4EU is co-financed under Horizon 2020 (grant agreement No 733032). The authors thank all principal investigators of the contributing studies for their participation and contribution to the HBM4EU Aligned Studies and the national program owners for their financial support. Further details on funding for all the participating studies can be found in the Supplemental Material, Table S12. As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures. publishersversion published

Published
2023

34. ALAD and APOE polymorphisms are associated with lead and mercury levels in Italian pregnant women and their newborns with adequate nutritional status of zinc and selenium

Author

Palir, Neža, primary, Stajnko, Anja, additional, Snoj Tratnik, Janja, additional, Mazej, Darja, additional, Briški, Alenka Sešek, additional, France-Štiglic, Alenka, additional, Rosolen, Valentina, additional, Mariuz, Marika, additional, Giordani, Elisa, additional, Barbone, Fabio, additional, Horvat, Milena, additional, and Falnoga, Ingrid, additional

Published
2023
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35. From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author

Gerofke, Antje, primary, David, Madlen, additional, Schmidt, Phillipp, additional, Vicente, Joana Lobo, additional, Buekers, Jurgen, additional, Gilles, Liese, additional, Colles, Ann, additional, Bessems, Jos, additional, Bastiaensen, Michiel, additional, Covaci, Adrian, additional, Den Hond, Elly, additional, Koppen, Gudrun, additional, Laeremans, Michelle, additional, Verheyen, Veerle J., additional, Černá, Milena, additional, Klánová, Jana, additional, Krsková, Andrea, additional, Zvonař, Martin, additional, Knudsen, Lisbeth E., additional, Koch, Holger M., additional, Jensen, Tina Kold, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Vogel, Nina, additional, Gabriel, Catherine, additional, Karakitsios, Spyros, additional, Papaioannou, Nafsika, additional, Sarigiannis, Denis, additional, Kakucs, Réka, additional, Középesy, Szilvia, additional, Rudnai, Péter, additional, Szigeti, Tamás, additional, Barbone, Fabio, additional, Rosolen, Valentina, additional, Guignard, Cedric, additional, Gutleb, Arno C., additional, Sakhi, Amrit Kaur, additional, Haug, Line Småstuen, additional, Janasik, Beata, additional, Ligocka, Danuta, additional, Estokova, Milada, additional, Fabelova, Lucia, additional, Kolena, Branislav, additional, Murinova, Lubica Palkovicova, additional, Petrovicova, Ida, additional, Richterova, Denisa, additional, Horvat, Milena, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Runkel, Agneta Annika, additional, Castaño, Argelia, additional, Esteban-López, Marta, additional, Pedraza-Díaz, Susana, additional, Åkesson, Agneta, additional, Lignell, Sanna, additional, Vlaanderen, Jelle, additional, Zock, Jan-Paul, additional, Schoeters, Greet, additional, and Kolossa-Gehring, Marike, additional

Published
2023
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38. Current exposure to phthalates and DINCH in European children and adolescents - Results from the HBM4EU Aligned Studies 2014 to 2021

Author

Vogel, Nina, Schmidt, Phillipp, Lange, Rosa, Gerofke, Antje, Sakhi, Amrit K, Haug, Line S, Jensen, Tina Kold, Frederiksen, Hanne, Szigeti, Tamás, Csákó, Zsófia, Murinova, Lubica Palkovicova, Sidlovska, Miroslava, Janasik, Beata, Wasowicz, Wojciech, Tratnik, Janja Snoj, Mazej, Darja, Gabriel, Catherine, Karakitsios, Spyros, Barbone, Fabio, Rosolen, Valentina, Rambaud, Loïc, Riou, Margaux, Murawski, Aline, Leseman, Daan, Koppen, Gudrun, Covaci, Adrian, Lignell, Sanna, Lindroos, Anna Karin, Zvonar, Martin, Andryskova, Lenka, Fabelova, Lucia, Richterova, Denisa, Horvat, Milena, Kosjek, Tina, Sarigiannis, Denis, Maroulis, Marios, Pedraza-Diaz, Susana, Cañas, Ana, Verheyen, Veerle J, Bastiaensen, Michiel, Gilles, Liese, Schoeters, Greet, Esteban-López, Marta, Castaño, Argelia, Govarts, Eva, Koch, Holger M, and Kolossa-Gehring, Marike

Subjects
HBM4EU, Phthalates, DINCH, Adolescents, Children, HBM, Exposure
Published
2023

39. From science to policy : how European HBM indicators help to answer related to and DINCH

Author

Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Cerna, Milena, Klanova, Jana, Krskova, Andrea, Zvonar, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loic, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Reka, Kozepesy, Szilvia, Rudnai, Peter, Szigeti, Tamas, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Smastuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castano, Argelia, Esteban-Lopez, Marta, Pedraza-Diaz, Susana, Akesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, and Kolossa-Gehring, Marike

Subjects
Human medicine
Abstract

Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014-2021), the usefulness of our indicators was demonstrated for the age group children (6-11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12-18 years), and time periods were compared using data from the DEMOCOPHES project (2011-2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differences. The impact indicator revealed that health risks based on exposure to DiBP cannot be excluded. This is an indication or flag for risk managers and policy makers that exposure to DiBP still is a relevant health issue. HBM indicators derived within HBM4EU are a valuable and important complement to existing indicator lists in the context of environment and health. Their applicability, current shortcomings and solution strategies are outlined.

Published
2023

42. Are Dietary Patterns Related to Cognitive Performance in 7-Year-Old Children? Evidence from a Birth Cohort in Friuli Venezia Giulia, Italy

Author

Marinoni, Michela, primary, Giordani, Elisa, additional, Mosconi, Cedric, additional, Rosolen, Valentina, additional, Concina, Federica, additional, Fiori, Federica, additional, Carletti, Claudia, additional, Knowles, Alessandra, additional, Pani, Paola, additional, Bin, Maura, additional, Ronfani, Luca, additional, Ferraroni, Monica, additional, Barbone, Fabio, additional, Parpinel, Maria, additional, and Edefonti, Valeria, additional

Published
2022
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43. Concurrent Assessment of Phthalates/HEXAMOLL® DINCH Exposure and Wechsler Intelligence Scale for Children Performance in Three European Cohorts of the HBM4EU Aligned Studies

Author

Rosolen, Valentina, primary, Giordani, Elisa, additional, Mariuz, Marika, additional, Parpinel, Maria, additional, Ronfani, Luca, additional, Vecchi Brumatti, Liza, additional, Bin, Maura, additional, Calamandrei, Gemma, additional, Mustieles, Vicente, additional, Gilles, Liese, additional, Govarts, Eva, additional, Baken, Kirsten, additional, Rodriguez Martin, Laura, additional, Schoeters, Greet, additional, Sepai, Ovnair, additional, Sovcikova, Eva, additional, Fabelova, Lucia, additional, Šidlovská, Miroslava, additional, Kolena, Branislav, additional, Kold Jensen, Tina, additional, Frederiksen, Hanne, additional, Kolossa-Gehring, Marike, additional, Lange, Rosa, additional, Apel, Petra, additional, Castano, Argelia, additional, Esteban López, Marta, additional, Jacobs, Griet, additional, Voorspoels, Stefan, additional, Jurdáková, Helena, additional, Górová, Renáta, additional, and Barbone, Fabio, additional

Published
2022
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44. Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies

Author

Poteser, Michael, primary, Laguzzi, Federica, additional, Schettgen, Thomas, additional, Vogel, Nina, additional, Weber, Till, additional, Zimmermann, Philipp, additional, Hahn, Domenica, additional, Kolossa-Gehring, Marike, additional, Namorado, Sónia, additional, Van Nieuwenhuyse, An, additional, Appenzeller, Brice, additional, Halldórsson, Thórhallur I., additional, Eiríksdóttir, Ása, additional, Haug, Line Småstuen, additional, Thomsen, Cathrine, additional, Barbone, Fabio, additional, Rosolen, Valentina, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Göen, Thomas, additional, Nübler, Stefanie, additional, Schäfer, Moritz, additional, Haji Abbas Zarrabi, Karin, additional, Gilles, Liese, additional, Martin, Laura Rodriguez, additional, Schoeters, Greet, additional, Sepai, Ovnair, additional, Govarts, Eva, additional, and Moshammer, Hanns, additional

Published
2022
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45. Trends of Exposure to Acrylamide as Measured by Urinary Biomarkers Levels within the HBM4EU Biomonitoring Aligned Studies (2000–2021)

Author

Poteser, Michael, primary, Laguzzi, Federica, additional, Schettgen, Thomas, additional, Vogel, Nina, additional, Weber, Till, additional, Murawski, Aline, additional, Schmidt, Phillipp, additional, Rüther, Maria, additional, Kolossa-Gehring, Marike, additional, Namorado, Sónia, additional, Nieuwenhuyse, An Van, additional, Appenzeller, Brice, additional, Dufthaksdóttir, Edda, additional, Olafsdóttir, Kristín, additional, Haug, Line Småstuen, additional, Thomsen, Cathrine, additional, Barbone, Fabio, additional, Rosolen, Valentina, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Göen, Thomas, additional, Nübler, Stefanie, additional, Schäfer, Moritz, additional, Zarrabi, Karin H. A., additional, Gilles, Liese, additional, Martin, Laura Rodriguez, additional, Schoeters, Greet, additional, Sepai, Ovnair, additional, Govarts, Eva, additional, and Moshammer, Hanns, additional

Published
2022
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48. Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants

Author

Gilles, Liese, primary, Govarts, Eva, additional, Rodriguez Martin, Laura, additional, Andersson, Anna-Maria, additional, Appenzeller, Brice M. R., additional, Barbone, Fabio, additional, Castaño, Argelia, additional, Coertjens, Dries, additional, Den Hond, Elly, additional, Dzhedzheia, Vazha, additional, Eržen, Ivan, additional, López, Marta Esteban, additional, Fábelová, Lucia, additional, Fillol, Clémence, additional, Franken, Carmen, additional, Frederiksen, Hanne, additional, Gabriel, Catherine, additional, Haug, Line Småstuen, additional, Horvat, Milena, additional, Halldórsson, Thórhallur Ingi, additional, Janasik, Beata, additional, Holcer, Nataša Janev, additional, Kakucs, Réka, additional, Karakitsios, Spyros, additional, Katsonouri, Andromachi, additional, Klánová, Jana, additional, Kold-Jensen, Tina, additional, Kolossa-Gehring, Marike, additional, Konstantinou, Corina, additional, Koponen, Jani, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Makris, Konstantinos C., additional, Mazej, Darja, additional, Morrens, Bert, additional, Murínová, Ľubica Palkovičová, additional, Namorado, Sónia, additional, Pedraza-Diaz, Susana, additional, Peisker, Jasmin, additional, Probst-Hensch, Nicole, additional, Rambaud, Loïc, additional, Rosolen, Valentina, additional, Rucic, Enrico, additional, Rüther, Maria, additional, Sarigiannis, Dimosthenis, additional, Tratnik, Janja Snoj, additional, Standaert, Arnout, additional, Stewart, Lorraine, additional, Szigeti, Tamás, additional, Thomsen, Cathrine, additional, Tolonen, Hanna, additional, Eiríksdóttir, Ása, additional, Van Nieuwenhuyse, An, additional, Verheyen, Veerle J., additional, Vlaanderen, Jelle, additional, Vogel, Nina, additional, Wasowicz, Wojciech, additional, Weber, Till, additional, Zock, Jan-Paul, additional, Sepai, Ovnair, additional, and Schoeters, Greet, additional

Published
2022
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