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2. Adipolin (C1QTNF12) is a new adipokine in female reproduction: expression and function in porcine granulosa cells.

Author

Barbe, Alix, Kurowska, Patrycja, Rame, Christelle, Froment, Pascal, Rak, Agnieszka, and Dupont, Joëlle

Subjects
GRANULOSA cells, GENE expression, OVARIAN follicle, PROTEIN kinase B, ADIPOKINES, STEROID synthesis
Abstract

In brief: Adipolin (C1QTNF12) has been described as a regulator of metabolism and is linked with the pathophysiology of PCOS. In this study, for the first time, we show the expression of C1QTNF12 in granulosa cells and its positive effect on porcine granulosa cell proliferation and steroid synthesis. Adipolin (C1QTNF12) is a recently discovered adipokine that plays an important role in glucose and insulin level regulation. Previous studies showed its reduced level in serum of women suffering from polycystic ovarian syndrome; however, whether C1QTNF12 regulates ovary function is still unknown. The aim of the study was first to determine the level of C1QTNF12 in the porcine ovarian follicles granulosa cells (Gc) and then its in vitro effect on proliferation and steroidogenesis as well as phosphorylation of several signalling pathways. Our results showed that the expression of C1QTNF12 was dependent on follicle size and was higher at the mRNA and protein level in Gc of small than large follicles from both prepubertal and mature animals. Similar pattern was observed for C1QTNF12 concentration in porcine follicular fluid. Additionally, we observed immunolocalisation of C1QTNF12 in Gc, theca cells and oocytes. We found that C1QTNF12 stimulated porcine Gc proliferation via the activation of protein kinase B (AKT). Moreover, C1QTNF12 enhanced progesterone, testosterone and oestradiol secretion by elevating STAR, CYP11A1, HSD3B and CYP19A1 mRNA expression and by activation of MAP3/1 pathway. Additionally, C1QTNF12 increased pMAP3/1-to-MAP3/1 protein expression ratio and enhanced IGF1-induced pTyr-IGF1Rß-to-IGFR1ß and pMAP3/1-to-MAP3/1 protein ratios. Taken together, C1QTNF12 could act directly on proliferation and steroid synthesis and serve as an important factor in in vivo ovarian follicle function, possibly regulating the course of folliculogenesis. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Chemerin impairs food intake and body weight in chicken: Focus on hypothalamic neuropeptides gene expression and AMPK signaling pathway

Author

Estienne, Anthony, primary, Ramé, Christelle, additional, Ganier, Patrice, additional, Chahnamian, Marine, additional, Barbe, Alix, additional, Grandhaye, Jérémy, additional, Dubois, Jean-Philippe, additional, Batailler, Martine, additional, Migaud, Martine, additional, Lecompte, François, additional, Adriaensen, Hans, additional, Froment, Pascal, additional, and Dupont, Joëlle, additional

Published
2021
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5. Maternal dietary supplementation with grape seed extract in reproductive hens increases fertility in females but decreases semen quality in males of the F1 generation

Author

Grandhaye, Jérémy, Lecompte, François, Chartrin, Pascal, Leconte, Maryse, Riva, Antonella, Barbe, Alix, JeanPierre, Éric, Caldas-Silveira, Erika, Ganier, Patrice, Chahnamian, Marine, Ramé, Christelle, Dupont, Joëlle, Froment, Pascal, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biologie des Oiseaux et Aviculture (BOA), Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Indena S.A.S, Indena SpA, Unité Expérimentale Avicole de Tours (UE PEAT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Conseil Régional du Centre-Val de Loire: Grants « Oxyferti » and 'Prevadi'., INRAE, Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Male, Heredity, Physiology, [SDV]Life Sciences [q-bio], Science, Eggs, Breeding, Muscle Development, Research and Analysis Methods, Biochemistry, Semen, Reproductive Physiology, Animal Cells, Testis, Medicine and Health Sciences, Animals, Sexual Maturation, Nutrition, Grape Seed Extract, Reproduction, Ovary, Body Weight, Fatty Acids, Biology and Life Sciences, Cell Biology, Muscle Analysis, Lipids, Bird Eggs, Sperm, Diet, Body Fluids, Semen Analysis, Oxidative Stress, Fertility, Germ Cells, Bioassays and Physiological Analysis, Physiological Parameters, Dietary Supplements, Medicine, Female, Chicken Eggs, Cellular Types, Anatomy, Reactive Oxygen Species, Tomography, X-Ray Computed, Chickens, Research Article
Abstract

International audience; Genetic selection in parental broiler breeders has increased their susceptibility to metabolic disorders and reproductive dysfunction. We have recently shown that maternal dietary grape seed extract (GSE) supplementation in hens improves fertility parameters, egg quality, oxidative stress in different tissues and the quality of F1 chicks. Here, we analysed the growth and fertility (both female and male) of the F1 generation animals and the quality of their offspring (F2 generation). Eggs issued from hens supplemented with GSE presented lower ROS production than control hens, suggesting a change in the embryonic environment. However, this did not affect the growth nor the body composition of male and female F1s from hatching to adulthood (37 weeks of age). At 37 weeks of age, the biochemistry analysis of the GSE-F1 muscle has revealed an increase in sensitivity to oxidative stress and a slight change in lipid composition. Both male and female F1-GSE groups presented a delay in puberty with a lower testis volume at 30 weeks of age and lower ovary development at 26 weeks of age. Adult GSE-F1 males did not present histological alterations of seminiferous tubules or semen production, but the semen quality was degraded due to higher oxidative stress and DNA-damaged spermatozoa compared with control F1 animals. In adult GSE-F1 females, despite the delay in puberty, the females laid more eggs of better quality (fewer broken eggs and a higher hatching rate). At hatching, the weight of the chicks from GSE-F1 females was reduced, and this effect was stronger in F2 male chicks (F2) compared with F2 control chicks (F2), because of the lower muscle volume. In conclusion, we can raise the hypothesis that maternal dietary GSE supplementation produces eggs with change in embryonic metabolism, which may affect in adulthood the fertility. The data obtained from the F1-GSE group pointed to a sex-specific modification with higher egg quality in females but semen sensitive to stress in males. Finally, male F2 chicks were leaner than control chicks. Thus, maternal dietary grape seed extract (GSE) supplementation in hens may impact on the fertility of the offspring in a sex-specific manner in subsequent generations.

Published
2020

6. Maternal dietary supplementation with grape seed extract in reproductive hens increases fertility in females but decreases semen quality in males of the F1 generation

Author

Grandhaye, Jérémy, primary, Lecompte, François, additional, Chartrin, Pascal, additional, Leconte, Maryse, additional, Riva, Antonella, additional, Barbe, Alix, additional, JeanPierre, Éric, additional, Caldas-Silveira, Erika, additional, Ganier, Patrice, additional, Chahnamian, Marine, additional, Ramé, Christelle, additional, Dupont, Joëlle, additional, and Froment, Pascal, additional

Published
2021
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9. Microbiota Changes Due to Grape Seed Extract Diet Improved Intestinal Homeostasis and Decreased Fatness in Parental Broiler Hens

Author

Grandhaye, Jeremy, primary, Douard, Veronique, additional, Rodriguez-Mateos, Ana, additional, Xu, Yifan, additional, Cheok, Alex, additional, Riva, Antonella, additional, Guabiraba, Rodrigo, additional, Zemb, Olivier, additional, Philippe, Catherine, additional, Monnoye, Magali, additional, Staub, Christophe, additional, Venturi, Eric, additional, Barbe, Alix, additional, Ramé, Christelle, additional, Dupont, Joelle, additional, and Froment, Pascal, additional

Published
2020
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10. Chemerin Impairs In Vitro Testosterone Production, Sperm Motility, and Fertility in Chicken: Possible Involvement of Its Receptor CMKLR1

Author

Estienne, Anthony, primary, Reverchon, Maxime, additional, Partyka, Agnieszka, additional, Bourdon, Guillaume, additional, Grandhaye, Jérémy, additional, Barbe, Alix, additional, Caldas-Silveira, Erika, additional, Rame, Christelle, additional, Niżański, Wojciech, additional, Froment, Pascal, additional, and Dupont, Joelle, additional

Published
2020
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11. A grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens

Author

Barbe, Alix, primary, Mellouk, Namya, additional, Ramé, Christelle, additional, Grandhaye, Jérémy, additional, Anger, Karine, additional, Chahnamian, Marine, additional, Ganier, Patrice, additional, Brionne, Aurélien, additional, Riva, Antonella, additional, Froment, Pascal, additional, and Dupont, Joëlle, additional

Published
2020
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12. A grape seed extract maternal dietary supplementation in reproductive hens reduces oxidative stress associated to modulation of plasma and tissue adipokines expression and improves viability of offsprings

Author

Barbe, Alix, primary, Mellouk, Namya, additional, Ramé, Christelle, additional, Grandhaye, Jérémy, additional, Staub, Christophe, additional, Venturi, Eric, additional, Cirot, Marine, additional, Petit, Angélique, additional, Anger, Karine, additional, Chahnamian, Marine, additional, Ganier, Patrice, additional, Callut, Olivier, additional, Cailleau-Audouin, Estelle, additional, Metayer-Coustard, Sonia, additional, Riva, Antonella, additional, Froment, Pascal, additional, and Dupont, Joëlle, additional

Published
2020
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13. A grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens: a link with plasma and ovarian cell adipokines expression?

Author

Barbe, Alix, primary, Mellouk, Namya, additional, Ramé, Christelle, additional, Grandhaye, Jérémy, additional, Anger, Karine, additional, Chahnamian, Marine, additional, Ganier, Patrice, additional, Brionne, Aurélien, additional, Riva, Antonella, additional, Froment, Pascal, additional, and dupont, joelle, additional

Published
2020
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14. Imagerie médicale, pour une mesure précise et non invasive chez le poulet de chair parental Cobb500

Author

Grandhaye, Jérémy, Lecompte, François, Staub, Christophe, Venturi, Eric, Plotton, Ingrid, Audouin, Estelle, Barbe, Alix, Ganier, Patrice, Rame, Christelle, Brière, Sylvain, Dupont, Joëlle, Froment, Pascal, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de la Recherche Agronomique (INRA), Centre Hospitalier Universitaire de Lyon, Biologie des Oiseaux et Aviculture (BOA), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Pôle d'Expérimentation Avicole de Tours (UE PEAT), Hendrix Genetics, France The french branch of WPSA (WPSA). FRA., Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [SDV.GEN] Life Sciences [q-bio]/Genetics, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2019

15. Effets d'extraits de pépins de raisins sur les paramètres métaboliques chez les poules reproductrices

Author

Barbe, Alix, Mellouk, Namya, Rame, Christelle, Grandhaye, Jérémy, Venturi, Eric, Cirot, Marine, Staub, Christophe, Petit, Angélique, Anger, Karine, Chahnamian, Marine, Ganier, Patrice, Callut, Olivier, Audouin, Estelle, Metayer-Coustard, Sonia, Mairel, François, Riva, Antonella, Froment, Pascal, Dupont, Joëlle, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Biologie des Oiseaux et Aviculture (BOA), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de la Recherche Agronomique (INRA), Pôle d'Expérimentation Avicole de Tours (UE PEAT), Indena SpA, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [SDV.GEN] Life Sciences [q-bio]/Genetics, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

16. Consequences of an antioxidant embryonic environment on broiler breeders reproductive activity

Author

Grandhaye, Jérémy, Estienne, Anthony, Lecompte, François, Staub, Christophe, Venturi, Eric, Cirot, Marine, Barbe, Alix, Ganier, Patrice, Rame, Christelle, Dupont, Joëlle, Froment, Pascal, ProdInra, Migration, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), Institut National de la Recherche Agronomique (INRA), Pôle d'Expérimentation Avicole de Tours (UE PEAT), France The french branch of WPSA (WPSA). FRA., and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [SDV.GEN] Life Sciences [q-bio]/Genetics, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2019

17. Vaspin (VASP) expression is regulated by several factors in porcine ovarian follicles in vitro study

Author

Kurowska, Patrycja, Barbe, Alix, Chmielinska, J., Dupont, Joëlle, Rak, A., Jagiellonian University, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), National Science Centre [2016/22/M/NZ9/00316], and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

18. Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Author

Mellouk, Namya, Ramé, Christelle, Barbe, Alix, Grandhaye, Jérémy, Froment, Pascal, and Dupont, Joëlle

Subjects
Article Subject
Abstract

Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species.

Published
2018
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19. Effect of grape seed extracts and procyanidin B2 on human granulosa cells: cell proliferation and apoptosis, steroidogenesis, oxidative stress and cell signaling

Author

Barbe, Alix, Bazilie, Romain, Mellouk, Namya, Grandhaye, Jérémy, Ramé, Christelle, Froment, Pascal, Dupont, Joëlle, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

20. Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review

Author

Kurowska, Patrycja, Barbe, Alix, Różycka, Marta, Chmielińska, Justyna, Dupont, Joelle, and Rak, Agnieszka

Subjects
endocrine system, Article Subject
Abstract

Apelin has been isolated from the bovine stomach extracts as an endogenous ligand of the previously orphan receptor APJ. Expression of the apelinergic system (apelin and APJ) was described in many organs where pleiotropic effects like regulation of food intake, body weight, or cardiovascular and immune function were described. Recent studies have shown that apelin also plays an important role in the regulation of female and male reproduction. Some data showed that the gene and protein of apelin/APJ are expressed in the hypothalamic-pituitary-gonad (HPG) axis tissue. Thus, apelin is synthesized locally in the hypothalamus, pituitary, ovaries, and testis of many species and has autocrine and/or paracrine effects. Most research indicates that apelin has an inhibitory effect on gonadotropin secretion and participates in the direct regulation of steroidogenesis, cell proliferation, and apoptosis in gonads. The article summarizes also results of a series of recent studies on the effect of apelin on reproduction pathology, like polycystic ovarian syndrome, endometriosis, and ovarian cancer. Many of these pathologies are still in critical need of therapeutic intervention, and recent studies have found that apelin can be targets in reproductive pathological states.

Published
2018
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21. Effects of Grape Seed Extract and Proanthocyanidin B2 on In Vitro Proliferation, Viability, Steroidogenesis, Oxidative Stress, and Cell Signaling in Human Granulosa Cells

Author

Barbe, Alix, primary, Ramé, Christelle, additional, Mellouk, Namya, additional, Estienne, Anthony, additional, Bongrani, Alice, additional, Brossaud, Adeline, additional, Riva, Antonella, additional, Guérif, Fabrice, additional, Froment, Pascal, additional, and Dupont, Joëlle, additional

Published
2019
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23. Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions

Author

Barbe, Alix, primary, Bongrani, Alice, additional, Mellouk, Namya, additional, Estienne, Anthony, additional, Kurowska, Patrycja, additional, Grandhaye, Jérémy, additional, Elfassy, Yaelle, additional, Levy, Rachel, additional, Rak, Agnieszka, additional, Froment, Pascal, additional, and Dupont, Joëlle, additional

Published
2019
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